Panagiotis Efentakis, Angeliki Choustoulaki, Grzegorz Kwiatkowski, Aimilia Varela, Ioannis V Kostopoulos, George Tsekenis, Ioannis Ntanasis-Stathopoulos, Anastasios Georgoulis, Constantinos E Vorgias, Harikleia Gakiopoulou, Alexandros Briasoulis, Constantinos H Davos, Nikolaos Kostomitsopoulos, Ourania Tsitsilonis, Meletios Athanasios Dimopoulos, Evangelos Terpos, Stefan Chłopicki, Maria Gavriatopoulou, Ioanna Andreadou
Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab's (Pem's) cardiotoxicity in vivo, seeking for translational prevention means. Cytotoxicity was investigated in primary cardiomyocytes and splenocytes, incubated with ipilimumab, Pem and avelumab. Pem's cross-reactivity was assessed by circular dichroism (CD) on biotechnologically produced human and murine PD-1 and in silico...
March 23, 2024: Basic Research in Cardiology