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https://www.readbyqxmd.com/read/28424766/the-need-for-hematology-nurse-education-in-low-and-middle-income-countries-a-community-case-study-in-tanzania
#1
Julie M Buser
Hematology-related diseases, such as anemia, malaria, sickle cell disease (SCD), and blood cancers, have differing rates of survival between high-income and low- and middle-income countries (LMICs). Nurses in LMICs have an unmet need for specialty training and education to address hematology and hemato-oncology disorders. A gap in the literature exists about hematology nurse education and clinical service demands in LMICs. This community case study documents a collaborative hematology and basic hemato-oncology education program to sustainably strengthen nurse capacity at a national referral hospital and university in Tanzania...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28417933/radiogenomic-analysis-of-oncological-data-a-technical-survey
#2
REVIEW
Mariarosaria Incoronato, Marco Aiello, Teresa Infante, Carlo Cavaliere, Anna Maria Grimaldi, Peppino Mirabelli, Serena Monti, Marco Salvatore
In the last few years, biomedical research has been boosted by the technological development of analytical instrumentation generating a large volume of data. Such information has increased in complexity from basic (i.e., blood samples) to extensive sets encompassing many aspects of a subject phenotype, and now rapidly extending into genetic and, more recently, radiomic information. Radiogenomics integrates both aspects, investigating the relationship between imaging features and gene expression. From a methodological point of view, radiogenomics takes advantage of non-conventional data analysis techniques that reveal meaningful information for decision-support in cancer diagnosis and treatment...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28397505/-current-recommendations-for-the-prevention-and-treatment-of-venous-thromboembolism-in-cancer-patients
#3
J Halámková, M Penka
About 20% of patients suffer from venous thromboembolism (VTE) during oncology disease. Active cancer, along with cancer therapy, increases the risk of VTE, especially in the first 6 months after diagnosis. Most often VTE accompanies haematological malignancies and CNS tumours, and gastrointestinal, breast, lung, ovary and uterine cancer. The presence of distant metastases, together with the implantation of a central venous catheter, increases the risk even more. A cancer patient also has a 2-5× higher risk of recurrence of VTE during anticoagulant therapy than patients without a malignancy, as well as a 2-6× higher risk of serious bleeding...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28396725/three-dimensional-radiation-dosimetry-using-polymer-gel-and-solid-radiochromic-polymer-from-basics-to-clinical-applications
#4
REVIEW
Yoichi Watanabe, Leighton Warmington, N Gopishankar
Accurate dose measurement tools are needed to evaluate the radiation dose delivered to patients by using modern and sophisticated radiation therapy techniques. However, the adequate tools which enable us to directly measure the dose distributions in three-dimensional (3D) space are not commonly available. One such 3D dose measurement device is the polymer-based dosimeter, which changes the material property in response to radiation. These are available in the gel form as polymer gel dosimeter (PGD) and ferrous gel dosimeter (FGD) and in the solid form as solid plastic dosimeter (SPD)...
March 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28387169/oncology-nurses-perspectives-on-safe-handling-precautions-a-qualitative-study
#5
Sevcan Topçu, Ayşe Beşer
BACKGROUND: Oncology nurses can be exposed to hazardous drugs during their preparation, administration, transfer and storage and elimination of their waste. AIM: This study was directed towards describing attitudes, opinions and experiences of nurses administering these drugs about safe handling precautions. METHODS: A qualitative study design was used. Fifteen nurses working for at least three months involved in preparation, administration and transfer of antineoplastic drugs and management of wastes...
April 7, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28367251/milestones-of-the-last-10%C3%A2-years-cns-cancer
#6
REVIEW
Christine Marosi, Matthias Preusser
For neuro-oncologists, much was accomplished in the last decade, including the establishment of the first standard of care (SOC) in this field of oncology. New treatment options boosted research in the whole field of neuro-oncology, as well clinical trials, translational and basic research. Accumulated data on molecular-genetic subgroups with distinct clinical outcomes in disease entities led to the establishment of new biomarkers and to the collaborative formulation of a new WHO classification of central nervous system tumors...
2017: Memo
https://www.readbyqxmd.com/read/28337673/progression-free-survival-as-a-surrogate-for-overall-survival-in-clinical-trials-of-targeted-therapy-in-advanced-solid-tumors
#7
Stefan Michiels, Everardo D Saad, Marc Buyse
Over the past 15 years, targeted therapy has revolutionized the systemic treatment of cancer. In parallel, there has been a growing debate on the choice of end points in clinical trials in oncology. This debate basically hinges on the choice between overall survival (OS) and progression-free survival (PFS). PFS is advantageous because it is measured earlier than OS, requires a smaller sample size than OS to achieve the desired power, and is not influenced by cross-over. On the other hand, PFS is prone to measurement error and bias, and may not capture the entire treatment effect on the outcomes of most interest to patients with an incurable disease: a prolonged survival and improved quality of life...
May 2017: Drugs
https://www.readbyqxmd.com/read/28333866/prevention-of-gastrointestinal-side-effects-in-paediatric-oncology-what-are-the-guidelines
#8
Karis K F Cheng
PURPOSE OF REVIEW: Gastrointestinal side-effects, particularly with regard to alimentary tract mucositis and chemotherapy-induced nausea and vomiting (CINV), continue to be frequent and debilitating symptomatic conditions among children and adolescents receiving cytotoxic cancer therapy. Further avenues of progress for mucositis and CINV prevention in paediatric oncology setting are warranted. RECENT FINDINGS: The current article reviews the major guidelines and literature published in 2016 pertaining to the prevention of mucositis and CINV...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28328309/ibpro-a-novel-short-duration-teaching-course-in-advanced-physics-and-biology-underlying-cancer-radiotherapy
#9
Michael C Joiner, Monica W Tracey, Sara E Kacin, Jay W Burmeister
This article provides a summary and status report of the ongoing advanced education program IBPRO - Integrated course in Biology and Physics of Radiation Oncology. IBPRO is a five-year program funded by NCI. It addresses the recognized deficiency in the number of mentors available who have the required knowledge and skill to provide the teaching and training that is required for future radiation oncologists and researchers in radiation sciences. Each year, IBPRO brings together 50 attendees typically at assistant professor level and upwards, who are already qualified/certified radiation oncologists, medical physicists or biologists...
March 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28315527/standards-of-practice-applying-genetics-and-genomics-resources-to-oncology%C3%A2
#10
Alice S Kerber, Nancy J Ledbetter
Knowledge about genetics and genomics and its application to oncology care is rapidly expanding and evolving. As a result, oncology nurses at all levels must develop and maintain their knowledge of genetics and genomics, as well as be aware of resources to guide practice. This article focuses on implementation of the standards described in the updated Genetics/Genomics Nursing: Scope and Standards of Practice by the basic practitioner.
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April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28297627/clinical-and-technical-aspects-of-genomic-diagnostics-for-precision-oncology
#11
Yuri Sheikine, Frank C Kuo, Neal I Lindeman
The emergence of precision medicine has been predicated on significant recent advances in diagnostic technology, particularly the advent of next-generation sequencing (NGS). Although the chemical technology underlying NGS is complex, and the computational biology expertise required to build systems to facilely interpret the results is highly specialized, the variables involved in designing and deploying a genomic testing program for cancer can be readily understood and applied by understanding several basic considerations...
March 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28294139/imaging-to-study-solid-tumour-origin-and-progression-lessons-from-research-and-clinical-oncology
#12
REVIEW
Stefania Raimondo, Giovanni Zito
Biomedical imaging in recent decades has clarified our understanding of normal and pathological cellular processes in vivo. In particular, this approach recently provided insights into processes occurring at a molecular or genetic level rather than at the anatomical level. The evolution of this discipline by engineering have led to its integration into biomedical research to (1) increase sensitivity and resolution imaging and to (2) improve tissue and cell specificity. Currently, imaging approaches are used in three different biomedical areas: (a) identification of cellular processes in physiological and disease state, (b) in vivo single cell imaging, and (c) identification of new prognostic and therapeutical strategies...
March 15, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28255687/identification-of-the-orsellinic-acid-synthase-pks63787-for-the-biosynthesis-of-antroquinonols-in-antrodia-cinnamomea
#13
Po-Wei Yu, Ting-Yu Cho, Ruey-Fen Liou, Shean-Shong Tzean, Tzong-Huei Lee
Antrodia cinnamomea, an endemic basidiomycete used as a health food in Taiwan, is known to synthesize antroquinonols, which were reported to have notable medicinal potential in oncology and immunology. However, the biosynthetic pathway of these compounds is currently unclear. Our previous study showed that a pks63787 knockout mutant of A. cinnamomea (∆pks63787) is deficient in the biosynthesis of several aromatic metabolites. In this study, we pointed by phylogenetic analysis that pks63787 likely encodes an orsellinic acid synthase...
March 2, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28252835/experiences-of-aromatherapy-massage-among-adult-female-cancer-patients-a-qualitative-study
#14
Alice N L Kwong, Simone S M Ho, Karen W S Wan, Rosita M L Ho, K M Chow
OBJECTIVE: The aim of the study was to explore the experiences towards aromatherapy massage (ATM) use, and to examine the perceived benefits and adverse effects of ATM among adult female cancer patients. METHOD: A qualitative research design was used. Fifteen women with cancer were recruited for semi-structured interviews. Sample recruitment was undertaken through cancer self-help groups and referrals of a private aromatherapy clinic by convenience sampling. The interview data were analyzed by thematic analysis...
March 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28246179/targeting-tgf-%C3%AE-signaling-for-therapeutic-gain
#15
Rosemary J Akhurst
Transforming growth factor βs (TGF-βs) are closely related ligands that have pleiotropic activity on most cell types of the body. They act through common heterotetrameric TGF-β type II and type I transmembrane dual specificity kinase receptor complexes, and the outcome of signaling is context-dependent. In normal tissue, they serve a role in maintaining homeostasis. In many diseased states, particularly fibrosis and cancer, TGF-β ligands are overexpressed and the outcome of signaling is diverted toward disease progression...
February 28, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28228841/an-update-on-the-management-of-breast-cancer-in-africa
#16
REVIEW
V Vanderpuye, S Grover, N Hammad, PoojaPrabhakar, H Simonds, F Olopade, D C Stefan
BACKGROUND: There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast cancer, similar poor prognostic factors are common to all countries. The five-year overall Survival rate for breast cancer patients does not exceed 60% for any low and middle-income country (LMIC) in Africa. In spite of the gains achieved over the past decade, certain characteristics remain the same such as limited availability of breast conservation therapies, inadequate access to drugs, few oncology specialists and adherence to harmful socio-cultural practices...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28218708/oncologic-photodynamic-therapy-basic-principles-current-clinical-status-and-future-directions
#17
REVIEW
Demian van Straten, Vida Mashayekhi, Henriette S de Bruijn, Sabrina Oliveira, Dominic J Robinson
Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a two-stage procedure, which starts with photosensitizer administration followed by a locally directed light exposure, with the aim of confined tumor destruction...
February 18, 2017: Cancers
https://www.readbyqxmd.com/read/28192596/integrating-next-generation-sequencing-into-pediatric-oncology-practice-an-assessment-of-physician-confidence-and-understanding-of-clinical-genomics
#18
Liza-Marie Johnson, Jessica M Valdez, Emily A Quinn, April D Sykes, Rose B McGee, Regina Nuccio, Stacy J Hines-Dowell, Justin N Baker, Chimene Kesserwan, Kim E Nichols, Belinda N Mandrell
BACKGROUND: The incorporation of genomic testing to identify targetable somatic alterations and predisposing germline mutations into the clinical setting is becoming increasingly more common. Despite its potential usefulness, to the authors' knowledge physician confidence with regard to understanding and applying genomic testing remains unclear, particularly within the realm of pediatric oncology. METHODS: Before initiating an institutional feasibility study regarding the integration of clinical genomic testing, the authors surveyed pediatric oncologists regarding their confidence around understanding of genomic testing, perceived usefulness of test results, preferences around the disclosure of germline test results, and possible risks and benefits of testing...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28187513/collaboration-to-accelerate-proteogenomics-cancer-care-the-department-of-veterans-affairs-department-of-defense-and-the-national-cancer-institute-s-applied-proteogenomics-organizational-and-learning-apollo-network
#19
L D Fiore, H Rodriguez, C D Shriver
The ability to interrogate cancer at the proteogenomic level has the potential to transform oncology care from trial-and-error treatment strategies based on the anatomy and genomic profiling of tumors to one that is precisely based on the tumor's molecular profile. The next step in the evolution of precision oncology is developing proteogenomic approaches that make no exclusive assumptions a priori as to the molecular level of the patient's disease. The DoD, VA, and NCI responded to the Cancer Moonshot initiative by linking each agency's unique capabilities in clinical and basic science, computing, and high-throughput sequencing...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28173885/cultural-influences-upon-advance-care-planning-in-a-family-centric-society
#20
Keson Tay, Rachel Jia Yu Lee, Shin Wei Sim, Sumytra Menon, Ravindran Kanesvaran, Lalit Kumar Radha Krishna
OBJECTIVE: Advanced care plans (ACPs) are designed to convey the wishes of patients with regards to their care in the event of incapacity. There are a number of prerequisites for creation of an effective ACP. First, the patient must be aware of their condition, their prognosis, the likely trajectory of the illness, and the potential treatment options available to them. Second, patient input into ACP must be free of any coercive factors. Third, the patient must be able to remain involved in adapting their ACP as their condition evolves...
February 8, 2017: Palliative & Supportive Care
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