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https://www.readbyqxmd.com/read/28444355/improvement-in-obstructive-sleep-apnea-with-weight-loss-is-dependent-on-body-position-during-sleep
#1
Simon A Joosten, Jun K Khoo, Bradley A Edwards, Shane A Landry, Matthew T Naughton, John B Dixon, Garun S Hamilton
Study Objectives: Weight loss fails to resolve obstructive sleep apnea (OSA) in most patients, however it is unknown as to whether weight loss differentially affects OSA in the supine compared to non-supine sleeping positions. We aimed to determine if weight loss in obese OSA patients results in a greater reduction in the non-supine Apnea Hypopnea Index (AHI) compared to the supine AHI, thus converting subjects into supine predominant OSA. Methods: Post hoc analysis of data from a randomized controlled trial assessing the effect of weight loss (bariatric surgery vs medical weight loss) on OSA in 60 obese subjects (body mass index: >35 and <55) with recently diagnosed (<6 months) OSA and AHI of ≥ 20 events/hour...
April 21, 2017: Sleep
https://www.readbyqxmd.com/read/28441418/relationship-between-acromial-morphological-variation-and-subacromial-impingement-a-three-dimensional-analysis
#2
Xinyu Li, Wei Xu, Ning Hu, Xi Liang, Wei Huang, Dianming Jiang, Hong Chen
PURPOSE: To evaluate the association of acromial morphology and subacromial impingement. METHODS: Bilateral shoulder computed tomography was performed in 138 patients who received shoulder arthroscopy. Measured parameters included: acromial tilt (AT), modified acromial tilt (mAT), acromial slope (AS), acromiohumeral interval (AHI), lateral acromial angle (LAA), acromial index (AI), critical shoulder angle (CSA), acromial anterior protrusion (AAP), and acromial inferior protrusion (AIP)...
2017: PloS One
https://www.readbyqxmd.com/read/28432036/increased-inflammation-from-childhood-to-adolescence-predicts-sleep-apnea-in-boys-a-preliminary-study
#3
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Fan He, Susan L Calhoun, Duanping Liao, Edward O Bixler
While chronic systemic inflammation in obstructive sleep apnea (OSA) has been traditionally considered a consequence of intermittent hypoxia, several treatment studies targeting inflammation suggest that this process may precede the development of the disorder. A recent cross-sectional study in the Penn State Child Cohort (PSCC) revealed that inflammation largely mediates the association between visceral adiposity and OSA in adolescence. The purpose of this study was to examine for the first time whether, longitudinally, inflammation precedes OSA during this developmental period...
April 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28431823/sleepiness-and-activity-in-heart-failure-patients-with-reduced-ejection-fraction-and-central-sleep-disordered-breathing
#4
Angela Atalla, Thomas W Carlisle, Anita K Simonds, Martin R Cowie, Mary J Morrell
OBJECTIVE: Patients with heart failure (HF) and sleep disordered breathing (SDB) are typically not sleepy, unlike patients without heart failure. Previous work in HF patients with obstructive SDB suggested that sleepiness was associated with a reduction in daytime activity. The consequences of predominately central SDB on sleepiness in HF are less well understood. The aim of this study was to test the hypothesis that subjective sleepiness is associated with reduced daytime activity in HF patients with central SDB, compared to those without SDB...
January 23, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28429349/association-between-the-severity-of-newly-diagnosed-obstructive-sleep-apnea-and-subclinical-carotid-atherosclerosis-in-patients-without-overt-cardiovascular-disease
#5
K Theodoropoulos, D Lykouras, K Karkoulias, D Damania, K Leou, O Lagiou, O A Meelu, A Rigopoulou, G D Dangas, G Hahalis, K Spiropoulos, I Starakis
OBJECTIVE: Obstructive Sleep Apnea (OSA) has been associated with both subclinical and accelerated atherosclerosis; however, it still remains unknown whether this association is unique or is mediated by the higher burden of co-existing cardio-metabolic disorders frequently seen in patients with OSA. PATIENTS AND METHODS: A total of 40 subjects without clinically diagnosed cardiovascular disease (CVD) referred for polysomnography test were included in the study. Subjects with apnea/hypopnea index (AHI > 15/h) were classified as moderate/severe OSA...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28427836/adherence-to-continuous-positive-airway-pressure-in-adults-with-an-intellectual-disability
#6
Kim A Luijks, Nele L Vandenbussche, Dirk Pevernagie, Sebastiaan Overeem, Sigrid Pillen
STUDY OBJECTIVES: This retrospective study evaluated the feasibility of continuous positive airway pressure (CPAP) therapy in adults with intellectual disabilities (ID). METHODS: CPAP therapy of 24 obstructive sleep apnea syndrome (OSA) patients with ID were compared to age- and sex-matched adults with normal cognitive functioning. All ID patients received an intensive in-hospital training protocol to stimulate adherence. Good adherence was defined as a use of >70% of the nights and >4 h/night...
March 30, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28426387/characterization-of-bimodal-chronotype-and-its-association-with-sleep-a-population-based-study
#7
Priscila Farias Tempaku, Juliana Ramirez Arruda, Diego Robles Mazzotti, Bruno S B Gonçalves, Mário Pedrazzoli, Lia Bittencourt, Sergio Tufik
The circadian system coordinates internal events in a daily schedule to make sure that the body systems are synchronized to environmental time and internal cues. One important behavioral aspect of the circadian system is the chronotype. It is usually assessed through subjective questionnaires, being the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ) one of the most used. It classifies individuals into three major categories: morning, evening, and intermediate types. Recently, it has been hypothesized the existence of a fourth chronotype, the bimodal type, through an algorithm derived from the MEQ responses...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28425583/sleep-apnea-syndrome-inflammation-and-oxidative-stress-in-hemodialysis-patients
#8
Olga Nikitidou, Euphemia Daskalopoulou, Aikaterini Papagianni, Vassilios Liakopoulos, Aikaterini Michalaki, Foteini Christidou, Paraskevi Argyropoulou, Dimitrios Kirmizis, Georgios Efstratiadis, Pavlos Nikolaidis, Michail Daniilidis, Nicholas Dombros
INTRODUCTION: Sleep apnea syndrome (SAS) is an established cardiovascular risk factor in the general population related to inflammation and oxidative stress and is very common among hemodialysis patients. Cardiovascular disease and its complications is the main cause of death among hemodialysis patients. The aim of the present study was to investigate the role of SAS in the promotion of inflammation and oxidative stress and thus in the augmentation of cardiovascular risk in hemodialysis patients...
April 20, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28425082/discriminating-between-positional-and-non-positional-obstructive-sleep-apnea-using-some-clinical-characteristics
#9
Abderrahim Oulhaj, Sharina Al Dhaheri, Brenda Bin Su, Mohammed Al-Houqani
PURPOSE: The primary objective of this paper was to identify significant factors associated with positional Obstructive Sleep Apnea (POSA) and to provide a clinical tool for discriminating non positional from POSA. Secondary objectives were about estimating the prevalence of POSA, comparing the polysomnographic variables across POSA and non-POSA patients. METHODS: This was a cross sectional study on 278 patients who completed an overnight sleep study for OSA assessment...
April 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28421376/using-the-stopbang-questionnaire-and-other-pre-test-probability-tools-to-predict-osa-in-younger-thinner-patients-referred-to-a-sleep-medicine-clinic
#10
Michael J McMahon, Karen L Sheikh, Teotimo F Andrada, Aaron B Holley
BACKGROUND: The STOPBANG questionnaire is used to predict the presence of obstructive sleep apnea (OSA). We sought to assess the performance of the STOPBANG questionnaire in younger, thinner patients referred to a sleep medicine clinic. METHODS: We applied the STOPBANG questionnaire to patients referred for level I polysomnography (PSG) at our sleep center. We calculated likelihood ratios and area under the receiver operator characteristic (AUROC) curve and performed sensitivity analyses...
April 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28419320/therapeutic-cpap-level-predicts-upper-airway-collapsibility-in-patients-with-obstructive-sleep-apnea-therapeutic-cpap-predicts-upper-airway-collapsibility
#11
Shane A Landry, Simon A Joosten, Danny J Eckert, Amy S Jordan, Scott A Sands, David P White, Atul Malhotra, Andrew Wellman, Garun S Hamilton, Bradley A Edwards
Study Objectives: Upper airway collapsibility is a key determinant of obstructive sleep apnea (OSA) which can influence the efficacy of certain non-CPAP treatment for OSA. However, there is no simple way to measure this variable clinically. The present study aimed to develop a clinically implementable tool to evaluate the collapsibility of a patient's upper airway. Methods: Collapsibility, as characterized by the passive pharyngeal critical closing pressure (Pcrit), was measured in 46 patients with OSA...
April 13, 2017: Sleep
https://www.readbyqxmd.com/read/28417683/tracheostomy-for-severe-pediatric-obstructive-sleep-apnea-indications-and-outcomes
#12
Christopher J Rizzi, Julian D Amin, Amal Isaiah, Tulio A Valdez, Anita Jeyakumar, Suzanne E Smart, Kevin D Pereira
Objectives (1) To describe characteristics of pediatric patients undergoing tracheostomy for obstructive sleep apnea (OSA). (2) To highlight perioperative events and outcomes of the procedure. Study Design Case series with chart review. Setting Four tertiary care academic children's hospitals. Subjects and Methods Twenty-nine children aged <18 years from January 1, 2010, to December 31, 2015, who underwent tracheostomy for severe OSA, defined as an apnea-hypopnea index (AHI) >10, were included in the study...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28409851/response-to-a-combination-of-oxygen-and-a-hypnotic-as-treatment-for-obstructive-sleep-apnoea-is-predicted-by-a-patient-s-therapeutic-cpap-requirement
#13
Shane A Landry, Simon A Joosten, Scott A Sands, David P White, Atul Malhotra, Andrew Wellman, Garun S Hamilton, Bradley A Edwards
BACKGROUND AND OBJECTIVE: Upper airway collapsibility predicts the response to several non-continuous positive airway pressure (CPAP) interventions for obstructive sleep apnoea (OSA). Measures of upper airway collapsibility cannot be easily performed in a clinical context; however, a patient's therapeutic CPAP requirement may serve as a surrogate measure of collapsibility. The present work aimed to compare the predictive use of CPAP level with detailed physiological measures of collapsibility...
April 13, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28408696/assessment-of-tongue-mechanical-properties-using-different-contraction-tasks
#14
Wen-Yang Li, Simon Gakwaya, Didier Saey, Frédéric Sériès
Inadequate UA dilator muscle function may play an important role in the pathophysiology of obstructive sleep apnea (OSA). To date, tongue mechanical properties have been mainly assessed using protrusion protocol with conflicting results, while performance during elevation task among patients with OSA remains unknown. This study was aimed to assess tongue muscle strength, strength stability, endurance time, fatigue indices and muscle total work, using elevation and protrusion tasks with repetitive isometric fatiguing contractions during awake in 12 normal+mild, 17 moderate and 11 severe patients with OSA, and to assess the influence of BMI and age...
April 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28408103/effect-of-cpap-on-diastolic-function-in-coronary-artery-disease-patients-with-nonsleepy-obstructive-sleep-apnea-a-randomized-controlled-trial
#15
Helena Glantz, Magnus C Johansson, Erik Thunström, Cecilia Wallentin Guron, Harun Uzel, Mustafa Saygin, Johan Herlitz, Yüksel Peker
BACKGROUND: Obstructive sleep apnea (OSA) has been associated with worse diastolic function in patients with coronary artery disease (CAD). This analysis determined whether continuous positive airway pressure (CPAP) treatment would improve diastolic function in CAD patients with nonsleepy OSA. METHODS: Between December 2005 and November 2010, 244 revascularized CAD patients with nonsleepy OSA (apnea-hypopnea index (AHI) ≥15/h, Epworth Sleepiness Scale [ESS] score<10) were randomly assigned to CPAP or no-CPAP...
March 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28406975/positional-therapy-in-sleep-apnoea-one-fits-all-what-determines-success-in-positional-therapy-in-sleep-apnoea-syndrome
#16
Natascha Troester, Michael Palfner, Markus Dominco, Christoph Wohlkoenig, Erich Schmidberger, Martin Trinker, Alexander Avian
INTRODUCTION: Positional therapy is a simple means of therapy in sleep apnoea syndrome, but due to controversial or lacking evidence, it is not widely accepted as appropriate treatment. In this study, we analysed data to positional therapy with regard to successful reduction of AHI and predictors of success. METHODS: All consecutive patients undergoing polysomnography between 2007 and 2011 were analysed. We used a strict definition of positional sleep apnoea syndrome (supine-exclusive sleep apnoea syndrome) and of therapy used...
2017: PloS One
https://www.readbyqxmd.com/read/28399695/the-effect-of-adenotonsillectomy-on-obstructive-sleep-apnea-in-children-with-down-syndrome
#17
Mosaad Abdel-Aziz, Khaled Azooz, Nader Naguib, Ramez Reda, Ahmed Kamel
OBJECTIVE: Children with Down syndrome (DS) are liable to develop obstructive sleep apnea (OSA) due to many anatomical airway abnormalities. The tonsils and adenoid occupy part of the airway space, and their removal may be helpful in relieving airway obstruction. The aim of this study was to assess the effectiveness of adenotonsillectomy in the treatment of OSA in those children. METHODS: Fifty DS children with difficult breathing were recruited, and they were subjected to polysomnographic examination (PSG)...
April 11, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28397994/prevalence-of-obesity-hypoventilation-syndrome-in-ambulatory-obese-patients-attending-pathology-laboratories
#18
Jean-Christian Borel, Fabrice Guerber, Ingrid Jullian-Desayes, Marie Joyeux-Faure, Nathalie Arnol, Nellie Taleux, Renaud Tamisier, Jean-Louis Pépin
BACKGROUND AND OBJECTIVE: The prevalence of obesity hypoventilation syndrome (OHS) in the unselected obese is unknown. Our objectives were: (i) to determine the prevalence of OHS in ambulatory obese patients not previously referred to a pulmonologist for suspicion of sleep breathing disorders and (ii) to assess whether venous bicarbonate concentration [HCO3(-)v ] can be used to detect OHS. METHODS: In this prospective multicentric study, we measured [HCO3(-)v ] in consenting obese patients attending pathology analysis laboratories...
April 11, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28397574/very-severe-obstructive-sleep-apnea-in-children-outcomes-of-adenotonsillectomy-and-risk-factors-for-persistence
#19
Amal Isaiah, Hisham Hamdan, Romaine F Johnson, Kamal Naqvi, Ron B Mitchell
Objectives (1) To describe the clinical, demographic and polysomnographic (PSG) characteristics of children with very severe obstructive sleep apnea (OSA) without significant comorbidities; (2) to assess the outcomes following tonsillectomy and adenoidectomy (T&A); and (3) to determine predictors of persistence of OSA after T&A. Study Design Case series with chart review. Setting Tertiary-level freestanding children's hospital. Subjects and Methods Seventy-four children aged 2 to 12 years who underwent T&A for very severe OSA (obstructive apnea-hypopnea index [AHI] >30) were included...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28397553/preoperative-drug-induced-sleep-endoscopy-improves-the-surgical-approach-to-treatment-of-obstructive-sleep-apnea
#20
Colin Huntley, David Chou, Karl Doghramji, Maurits Boon
OBJECTIVE: Drug induced sleep endoscopy (DISE) allows for preoperative evaluation of the specific site and character of upper airway obstruction in obstructive sleep apnea (OSA). We aim to assess the impact DISE has on customizing the surgical plan and evaluate its role in surgical success. METHODS: We retrospectively reviewed patients undergoing surgery for OSA. We compared those patients undergoing preoperative DISE to those that did not to assess procedures performed and surgical outcomes...
June 2017: Annals of Otology, Rhinology, and Laryngology
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