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https://www.readbyqxmd.com/read/28526655/digital-morphometrics-a-new-upper-airway-phenotyping-paradigm-in-obstructive-sleep-apnea
#1
Richard J Schwab, Sarah E Leinwand, Cary B Bearn, Greg Maislin, Ramya Bhat Rao, Adithya Nagaraja, Stephen Wang, Brendan T Keenan
BACKGROUND: Obstructive sleep apnea (OSA) is associated with changes in pharyngeal anatomy. The goal of this study was to objectively and reproducibly quantify pharyngeal anatomy using digital morphometrics based on a laser ruler, and to assess differences between apneics and controls and associations with AHI (apnea-hypopnea index). This is the first study to use digital morphometrics to quantify intraoral risk factors for OSA. METHODS: Digital photographs were obtained using an intraoral laser ruler and digital camera in 311 controls (mean AHI=4...
May 16, 2017: Chest
https://www.readbyqxmd.com/read/28526545/obstructive-sleep-apnoea-and-right-ventricular-function-a-combined-assessment-by-speckle-tracking-and-three-dimensional-echocardiography
#2
Agostino Buonauro, Maurizio Galderisi, Ciro Santoro, Angelo Canora, Maria Luisa Bocchino, Francesco Lo Iudice, Maria Lembo, Roberta Esposito, Sabrina Castaldo, Bruno Trimarco, Alessandro Sanduzzi
BACKGROUND: Little is known on right ventricular (RV) involvement in obstructive sleep apnoea (OSA). This study aimed at evaluating early RV dysfunction by standard and advanced echocardiography in OSA. METHODS: Fifty-nine OSA patients without heart failure and 29 age-matched controls underwent standard, speckle tracking and real time 3D echocardiography of right ventricle. OSA patients performed lung function tests and overnight cardio-respiratory monitoring with evaluation of apnea-hypopnea index (AHI)...
May 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28522103/urinary-biomarkers-and-obstructive-sleep-apnea-in-patients-with-down-syndrome
#3
Ibrahim Elsharkawi, David Gozal, Eric A Macklin, Lauren Voelz, Gil Weintraub, Brian G Skotko
STUDY OBJECTIVES: The study aimed to compare urinary biomarkers in patients with Down syndrome (DS) with and without obstructive sleep apnea (OSA) to those of age- and sex-matched neurotypically developing healthy controls (HC). We further investigated whether we could predict OSA in patients with DS using these biomarkers. METHODS: Urine samples were collected from 58 patients with DS the night before or the morning after their scheduled overnight polysomnogram or both, of whom 47 could be age- and sex-matched to a sample of 43 HC...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522088/frequency-of-snoring-rather-than-apnea-hypopnea-index-predicts-both-cognitive-and-behavioral-problems-in-young-children
#4
Dale L Smith, David Gozal, Scott J Hunter, Leila Kheirandish-Gozal
OBJECTIVE: Primary snoring (PS) and obstructive sleep apnea (OSA) not only affect the quality of sleep in a large number of young children, but have also been repeatedly associated with a variety of behavioral and cognitive problems. However, little is known about the potentially differing relationships of behavioral and cognitive pathology within the sleep disordered breathing (SDB) spectrum. METHOD: This study examined data from an enriched for snoring community sample of 631 children aged between 4 and 10 years...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522081/natural-course-and-potential-prognostic-factors-for-sleep-disordered-breathing-in-multiple-system-atrophy
#5
Yasuyoshi Ohshima, Hideaki Nakayama, Naho Matsuyama, Satoshi Hokari, Takuro Sakagami, Tomoe Sato, Toshiyuki Koya, Tetsuya Takahashi, Toshiaki Kikuchi, Masatoyo Nishizawa, Takayoshi Shimohata
OBJECTIVE/BACKGROUND: Multiple system atrophy (MSA) frequently results in the development of sleep-disordered breathing (SDB). Few reports have described the natural course of this phenomenon. The aim of the present study was to determine the natural course of SDB and prognostic factors associated with such conditions in MSA. PATIENTS/METHODS: Twenty-four consecutive patients were recruited with probable MSA, who had not been treated with continuous positive airway pressure (CPAP) and had undergone overnight polysomnography (PSG) more than once following the development of snoring or stridor...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522078/a-randomized-controlled-trial-of-positional-therapy-versus-oral-appliance-therapy-for-position-dependent-sleep-apnea
#6
Linda Benoist, Maurits de Ruiter, Jan de Lange, Nico de Vries
OBJECTIVE: To compare the effectiveness of positional therapy (PT) with the sleep position trainer (SPT) to oral appliance therapy (OAT) in patients with mild-to-moderate positional obstructive sleep apnea (POSA). METHODS: Multicenter, prospective, randomized, controlled trial. Patients with mild-to-moderate POSA (apnea-hypopnea index (AHI) ≥5 ≤ 30/hour sleep) were randomized for PT or OAT. Polysomnography was repeated after 3 months. Efficacy, adherence, mean disease alleviation (MDA), quality of life, dropouts and adverse events were evaluated...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28513057/systemic-inflammation-and-alterations-to-cerebral-blood-flow-in-obstructive-sleep-apnea
#7
Hsiu-Ling Chen, Hsin-Ching Lin, Cheng-Hsien Lu, Pei-Chin Chen, Chih-Cheng Huang, Kun-Hsien Chou, Mao-Chang Su, Michael Friedman, Yi-Wen Chen, Wei-Che Lin
Systemic inflammation and alterations to regional cerebral blood flow (CBF) have been reported previously in obstructive sleep apnea (OSA). This study utilized arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI) to evaluate CBF in OSA patients and determine its relationship with systemic inflammation. Twenty male patients with moderate and severe OSA [apnea-hypopnea index (AHI) >15] and 16 healthy male volunteers (AHI <5) were recruited. Early- or late-phase changes in leucocyte apoptosis and its subsets were determined by flow cytometry...
May 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28502282/morning-diastolic-blood-pressure-may-be-independently-associated-with-severity-of-obstructive-sleep-apnea-in-non-hypertensive-patients-a-cross-sectional-study
#8
Łukasz Mokros, Wojciech Kuczyński, Łukasz Franczak, Piotr Białasiewicz
STUDY OBJECTIVES: The aim of the study is to verify a possible association between arterial blood pressure and obstructive sleep apnea (OSA) severity in a group of non-hypertensive patients. METHODS: This is a retrospective study of 1,171 consecutive patients referred to the sleep laboratory with complaints suggestive of OSA who underwent standard diagnostic polysomnography. In total, 454 patients with no history of arterial hypertension nor had received any such treatment were selected from this group...
May 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28501722/spatial-qrs-t-angle-in-patients-with-newly-diagnosed-obstructive-sleep-apnea-syndrome
#9
Paweł Kiciński, Todd Schlegel, Andrzej Dybała, Maciej Zakrzewski, Sylwia Przybylska-Kuć, Wojciech Myśliński, Jerzy Mosiewicz, Stanisław Głuszek, Andrzej Jaroszyński
PURPOSE: The aim of the study was to assess the spatial QRS-T angle (QRS-TA) in a group of newly diagnosed and untreated adult patients with obstructive sleep apnea syndrome (OSAS) and to identify potential factors affecting this parameter. PATIENTS AND METHODS: The study group (PSG-confirmed OSAS) included 62 individuals, aged 51.7±10.3 years. The control group consisted of 25 individuals, aged 46.6±16.6 years with no sleep-disordered breathing. The diagnosis of OSAS and assessment of its severity was based on unattended all-night screening polysomnography...
May 11, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28485295/hearing-loss-in-mild-osas-and-simple-snoring-patients
#10
Maria Carla Spinosi, Francesca D'Amico, Giulio Passali, Cemal Cingi, Hugo Rodriguez, Desiderio Passali
Introduction Obstructive Sleep Apnea Syndrome (OSAS) is characterized by recurrent episodes of prolonged partial or complete obstruction of the upper airways. Several study groups studied the effect of snoring and OSAS on auditory function, showing an increase in the incidence of hearing loss in apneic patients, an earlier onset and/or a degree of hearing loss deeper than in peers. The aim of our study is to evaluate the audiological performance of a population of simple-snoring patients and patients suffering from mild OSAS, and the impact that such pathological condition can have on the auditory function, considering the significant levels of chronic noise...
April 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28485064/revisits-after-adenotonsillectomy-in-children-with-sleep-disordered-breathing-a-retrospective-single-institution-study
#11
I-Sheng Chang, Kun-Tai Kang, Chia-Chen Tseng, Wen-Chin Weng, Tzu-Yu Hsiao, Pei-Lin Lee, Wei-Chung Hsu
OBJECTIVE: To investigated emergency room (ER) revisits and hospital readmissions following adenotonsillectomy (T&A) in children with sleep-disordered breathing (SDB), and correlations between SDB severity and ER revisits. DESIGN: Retrospective chart-review study. SETTING: Tertiary referral centre. PARTICIPANT: 610 consecutive children underwent T&A for treating SDB. MAIN OUTCOME MEASURES: SDB severity was defined according to the apnoea-hypopnoea index (AHI) (primary snoring = AHI < 1; mild = AHI 1-5; moderate = AHI 5-10; and severe = AHI > 10)...
May 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28484888/depression-and-anxiety-are-common-in-acute-hiv-infection-and-associate-with-plasma-immune-activation
#12
Joanna Hellmuth, Donn Colby, Victor Valcour, Duanghathai Suttichom, Serena Spudich, Jintanat Ananworanich, Peeriya Prueksakaew, Napapon Sailasuta, Isabel Allen, Linda L Jagodzinski, Bonnie Slike, Derek Ochi, Robert Paul
This observational study of 123 Thai participants sought to determine the rate and severity of affective symptoms during acute HIV infection (AHI) and possible associations to disease mechanisms. At diagnosis, just prior to starting combination antiretroviral therapy (cART), AHI participants completed assessments of depression and anxiety symptoms that were repeated at 4, 12, and 24 weeks. Blood markers of HIV infection and immune activation were measured at study entry, with optional cerebrospinal fluid measures...
May 8, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28483245/the-watch-pat-in-pediatrics-sleep-disordered-breathing-pilot-study-on-children-with-negative-nocturnal-pulse-oximetry
#13
Agostino Serra, Salvatore Cocuzza, Luigi Maiolino, Alessandro Abramo, Giacomo Spinato, Giovanni Tonoli, Maurizio Amadori, Doriano Politi, Giancarlo Tirelli, Roberto Spinato, Paola Di Mauro
OBJECTIVES: The main purpose of this study was to determine the efficacy of Watch-PAT in Pediatric Sleep Disordered Breathing (PSDB) diagnosis in children with symptoms suggestive of PSDB, in which the nocturnal pulse oximetry was negative according to the Brouilette criteria. METHODS: We enrolled 28 patients aged between 5 and 12 years (mean age: 7.75 ± 1.69), who underwent the registration with Watch-PAT, that utilizes the Peripheral Arterial Tone (PAT), AHI, RDI, body position, snoring, pulse oximetry and actigraphy...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28476457/recognition-and-treatment-of-sleep-disordered-breathing-in-obese-hospitalized-patients-may-improve-survival-the-hosmed-database
#14
Sunil Sharma, Umer Mukhtar, Colleen Kelly, Paul Mather, Stuart F Quan
PURPOSE: Sleep disordered breathing is a common sleep disorder. Recent studies have shown that hospitalized obese patients have a high likelihood of unrecognized Sleep disordered breathing. However, no systematic large study has so far evaluated the outcomes of a screening program. This study provides demographic, clinical and outcome data from a screening program at a tertiary care academic center. METHODS: Subjects were 5062 patients screened from March 2013 to July 2016...
May 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28474074/-measurement-of-temporomandibular-joint-space-of-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#15
Rui Zhao, Wei-Sheng Wen, Ge Yang, Ye Tao, Rui Jia
PURPOSE: This research evaluated the morphological differences of temporomandibular joint (TMJ) between patients with obstructive sleep apnea hypopnea Syndrome (OSAHS) and normal population using magnetic resonance imaging (MRI). METHODS: Eighteen OSAHS patients were admitted from January 2014 to May 2016 and 18 healthy adults were chosen as control. OSAHS patients were divided into three sub-groups (n=6), i.e. the mild group, the moderate group and the severe group, according to apnea and hypopnea index (AHI)...
February 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28472141/prediction-of-the-severity-of-obstructive-sleep-apnea-by-anthropometric-features-via-support-vector-machine
#16
Wen-Te Liu, Hau-Tieng Wu, Jer-Nan Juang, Adam Wisniewski, Hsin-Chien Lee, Dean Wu, Yu-Lun Lo
To develop an applicable prediction for obstructive sleep apnea (OSA) is still a challenge in clinical practice. We apply a modern machine learning method, the support vector machine to establish a predicting model for the severity of OSA. The support vector machine was applied to build up a prediction model based on three anthropometric features (neck circumference, waist circumference, and body mass index) and age on the first database. The established model was then valided independently on the second database...
2017: PloS One
https://www.readbyqxmd.com/read/28469718/prevalence-and-risk-factors-of-obstructive-sleep-apnea-syndrome-in-a-saudi-arabian-population
#17
Siraj Omar Wali, Bahaa Abalkhail, Ayman Krayem
BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder worldwide; however, epidemiological studies on its prevalence lack in Saudi Arabia. This study aimed to determine the prevalence and risk factors of OSA in Saudi Arabia. METHODS: The study was performed from 2013 to 2015 in two stages. The screening stage was first; a random sample of Saudi employees (n = 2682) 30-60 years of age completed a survey that included the Wisconsin questionnaire. According to these data, the subjects were categorized as habitual, moderate, or nonsnorers (NSs)...
April 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28457559/periodic-limb-movements-of-sleep-are-associated-with-an-increased-prevalence-of-atrial-fibrillation-in-patients-with-mild-sleep-disordered-breathing
#18
Jiang Xie, C Anwar A Chahal, Naima Covassin, Phillip J Schulte, Prachi Singh, Narat Srivali, Virend K Somers, Sean M Caples
BACKGROUND: Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF) is unclear, especially in patients with sleep-disordered breathing (SDB). This study sought to investigate whether PLMS were associated with increased AF prevalence, independent of established risk factors. METHODS: We performed a cross-sectional study of patients who underwent attended polysomnography at Mayo Clinic from 2011 to 2014...
April 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28455734/formula-for-predicting-osa-and-the-apnea-hypopnea-index-in-koreans-with-suspected-osa-using-clinical-anthropometric-and-cephalometric-variables
#19
Seon Tae Kim, Kee Hyung Park, Seung-Heon Shin, Ji-Eun Kim, Chi-Un Pae, Kwang-Pil Ko, Hee Young Hwang, Seung-Gul Kang
PURPOSE: This study developed formulas to predict obstructive sleep apnea (OSA) and the Apnea-Hypopnea Index (AHI) in Korean patients with suspected OSA using clinical, anthropometric, and cephalometric variables. METHODS: We evaluated relevant variables in 285 subjects with suspected OSA. These included demographic characteristics, sleep-related symptoms, medical history, clinical scales, anthropometric measurements including facial surface measurements, and cephalometric measurements...
April 29, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28455120/obstructive-sleep-apnea-is-associated-with-increased-qt-corrected-interval-dispersion-the-effects-of-continuous-positive-airway-pressure
#20
Nagihan Bilal, Nursel Dikmen, Fulsen Bozkus, Aylin Sungur, Selman Sarica, Israfil Orhan, Anil Samur
INTRODUCTION: Severe obstructive sleep apnea (OSA) is associated with increased QT corrected interval dispersion (QTcd) and continuous positive airway pressure (CPAP) is thought to improve this arrhythmogenic marker. OBJECTIVE: The aim of the study was to determine the decrease of ratio of cardiovascular risk in patients with obstructive sleep apnea. METHODS: The study included 65 patients with severe OSA who had an apnea-hypopnea index (AHI) score of >30...
March 31, 2017: Brazilian Journal of Otorhinolaryngology
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