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Depuy Synthes Spine

Ron N Alkalay, Robert Adamson, Michael W Groff
BACKGROUND CONTEXT: In the lumbar spine, end plate preparation for the interbody fusion cages may critically affect the cage's long term performance. This study investigated the effect of the interbody cage design on the compliance and cage subsidence of instrumented spines under cyclic compression. PURPOSE: To quantify the role of cage geometry and bone density on the stability of the spinal construct in response to cyclic compressive loads. STUDY DESIGN: Changes in the cage-bone interface and the effect of bone density on these changes were evaluated in a human cadaveric model for three intervertebral cage designs...
March 8, 2018: Spine Journal: Official Journal of the North American Spine Society
Srikanth Naga Divi, Mark M Mikhael
STUDY DESIGN: Retrospective case series. PURPOSE: To report our early experience using allogenic mesenchymal cellular bone matrix (CBM) products in cervical spine fusion. OVERVIEW OF LITERATURE: Multi-level cervical fusions have historically yielded lower fusion rates than single level fusions, especially in patients with high risk medical comorbidities. At this time, significant literature in cervical fusion outcomes with this cellular allograft technology is lacking...
June 2017: Asian Spine Journal
Chih-Chang Chang, Jau-Ching Wu, Peng-Yuan Chang, Mei-Yin Yeh, Yi-Hsuan Kuo, Li-Yu Fay, Tsung-Hsi Tu, Wen-Cheng Huang, Henrich Cheng
There are many kinds of artificial discs available for cervical disc arthroplasty (CDA), with various designs of fixation and articulation mechanisms. Each of these designs has different features and theoretically fits most optimally in selected types of patients. However, there has been insufficient literature to guide individualized selection among these CDA devices. Since CDA aims to restore the joint function rather than arthrodesis, tailor-made size, shape, and mechanical properties should be taken into account for each candidate's target disc...
January 2017: Neurosurgical Focus
Tsung-Hsi Tu, Chih-Chang Chang, Jau-Ching Wu, Li-Yu Fay, Wen-Cheng Huang, Henrich Cheng
The most commonly accepted indications for cervical disc arthroplasty (CDA) are 1- and 2-level cervical disc herniation or spondylosis causing radiculopathy or myelopathy that is refractory to medical management. Unlike anterior cervical discectomy and fusion (ACDF), which eliminates motion, CDA aims to restore the physiological range of motion of the indexed joint. Thus, the effect of indirect decompression gained by the insertion of a sufficiently large interbody graft and incorporation into arthrodesis after ACDF cannot be duplicated for CDA...
January 2017: Neurosurgical Focus
Sinan Karaca, Ahmet Onur Akpolat, Ahmet Oztermeli, Mehmet Nuri Erdem, Mehmet Aydogan
OBJECTIVE: The aim of this study was to assess appropriateness of the sizes of available cervical disc prostheses based on tomographic measurement of human cervical vertebrae. METHODS: The anatomic dimensions of the C3-C7 segments were measured on 50 patients (age range 26-47 years) with computerized tomography scan and compared with the sizes of the popular cervical total disc prostheses (CTDP) at the market [Bryan (Medtronic), Prodisc-C (Synthes), Prestige LP (Medtronic), Discover (DePuy)]...
October 2016: Acta Orthopaedica et Traumatologica Turcica
Kenneth K Hansraj
INTRODUCTION: Spine surgeons are embracing advanced biologic technologies in an attempt to help millions of people achieve a better outcome in spine surgery. These new technologies may be complicated to understand, partly because the contribution of different types of cells has not been definitively identified. This paper describes the characteristics of the stem cells used in spine surgery, including their actions and possible complications. The description necessitates an overview of all studies to date on the use of stem cells in spine surgery, as well as other cells used in cellular therapy...
October 26, 2016: Surgical Technology International
Ha Son Nguyen, Andrew Lozen, Ninh Doan, Michael Gelsomin, Saman Shabani, Dennis Maiman
Dural ectasia is frequently associated with connective tissue disorders or inflammatory conditions. Presentation in a patient without known risk factors is rare. Moreover, the literature regarding the treatment options for symptomatic dural ectasia is controversial, variable, and limited. A 62-year-old female presents with intractable, postural headaches for years. A lumbar puncture revealed opening pressure 3 cm of water. A computed tomography myelogram of the spine demonstrated erosion of her sacrum due to a large lumbosacral dural ectasia...
October 2015: Journal of Craniovertebral Junction and Spine
Adam S Kanter, Gurpreet S Gandhoke, William C Welch, Paul M Arnold, Joseph S Cheng, David O Okonkwo
This prospective clinical study evaluated the use of a composite bone void filler (ChronOS Strip, DePuy Synthes, West Chester, PA, USA), combined with bone marrow aspirate plus local autologous bone, in a series of patients undergoing instrumented posterolateral spinal fusion with interbody support. Seventy-six patients were enrolled and treated per protocol at 13 clinical sites. At 24 months, 55/76 patients (72%) were evaluated, with 49/76 (65%) having sufficient data to determine the primary endpoint. The primary endpoint, posterolateral fusion success, was achieved in 48/54 (88...
March 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Markus Loibl, Mariya Korsun, Julian Reiss, Boyko Gueorguiev, Michael Nerlich, Carsten Neumann, Florian Baumann
INTRODUCTION: Surgical management of thoracolumbar trauma involves correction of posttraumatic deformity and placement of transpedicular instrumentation. The aim of this prospective cohort study was to generate first results reflecting the clinical and radiological outcome of patients treated with percutaneous dorsal instrumentation for fractures of the thoracic and lumbar spine with the use of a transpedicular new Schanz Screw system (USS Fracture MIS, DePuy Synthes). METHODS: A total of 26 patients with fractures of the thoracic and lumbar spine were operatively treated with bi-segmental dorsal instrumentation between January and December 2012...
October 2015: Injury
Peter G Passias, Alexandra Soroceanu, Justin Scheer, Sun Yang, Anthony Boniello, Justin S Smith, Themistocles Protopsaltis, Han J Kim, Frank Schwab, Munish Gupta, Eric Klineberg, Gregory Mundis, Renaud Lafage, Robert Hart, Christopher Shaffrey, Virginie Lafage, Christopher Ames
BACKGROUND CONTEXT: Cervical deformity (CD) is prevalent among patients with adult spinal deformity (ASD). The effect of baseline cervical alignment on achieving optimal thoracolumbar alignment in ASD surgery is unclear. PURPOSE: This study assesses the relationship between preoperative (preop) cervical spinal parameters and global alignment after thoracolumbar ASD surgery at 2-year follow-up. STUDY DESIGN/SETTING: This study is a retrospective review of a multicenter, prospective database...
August 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Innocent Njoku, Marjan Alimi, Lewis Z Leng, Benjamin J Shin, Andrew R James, Sandeep Bhangoo, Apostolos John Tsiouris, Roger Härtl
OBJECT: Anterior cervical plating decreases the risk of pseudarthrosis following anterior cervical discectomy and fusion (ACDF). Dysphagia is a common complication of ACDF, with the anterior plate implicated as a potential contributor. A zero-profile, stand-alone polyetheretherketone (PEEK) interbody spacer has been postulated to minimize soft-tissue irritation and postoperative dysphagia, but studies are limited. The object of the present study was to determine the clinical and radiological outcomes for patients who underwent ACDF using a zero-profile integrated plate and spacer device, with a focus on the course of postoperative prevertebral soft-tissue thickness and the incidence of dysphagia...
October 2014: Journal of Neurosurgery. Spine
James J Yue, Fred F Mo
BACKGROUND: The objective of this clinical study is to evaluate the safety and effectiveness of the Activ-L Artificial Disc for treatment of single-level degenerative disc disease of the lumbar spine in patients who have been unresponsive to at least six months of prior conservative care. The hypothesis of the study is that the Activ-L Disc is non-inferior to the control (the Charité Artificial Disc [DePuy Spine] or ProDisc-L Total Disc Replacement [Synthes Spine]) with respect to the rate of individual subject success at 24 months...
April 9, 2010: BMC Surgery
Charles Rosen, P Douglas Kiester, Thay Q Lee
The Charité III (DePuy Spine, Inc, Raynham, Massachusetts) and ProDisc II (Synthes Spine, West Chester, Pennsylvania) artificial disk replacements were approved for use by the United States Food and Drug Administration in October 2004 and January 2006, respectively. The purpose of this study was to retrospectively review 29 patients receiving either disk replacement who presented with complications to the University of California Irvine Spine Center. Specifically, patient outcome data from the Oswestry Disability Index (ODI) and the SF-36 were analyzed...
August 2009: Orthopedics
M Reinhold, W Schmölz, F Canto, D Krappinger, M Blauth, C Knop
BACKGROUND: In recent years, the use of expandable titanium cages for vertebral body replacement in the thoracolumbar spine has been well established for the treatment of tumors, unstable traumatic lesions, or posttraumatic deformity. Collapse of the implant into the vertebral body remains a point of concern. A biomechanical compression test was designed to assess implant subsidence for a newly developed prototype for vertebral body replacement in the thoracolumbar spine using human cadaveric lumbar vertebrae...
April 2007: Der Unfallchirurg
C Khodadadyan-Klostermann, J Schaefer, Ph Schleicher, R Pflugmacher, T Eindorf, N P Haas, F Kandziora
INTRODUCTION: Due to a recent increase in the commercial availability of expandable cages for vertebral body replacement, this study was designed to gain more information about their biomechanical properties. All three expandable cages evaluated in this study are approved for clinical use, but little knowledge about their biomechanical properties exists. MATERIAL AND METHODS: Human thoracolumbar spines (T11 to L3) ( n=32) were tested in flexion, extension, axial rotation, and lateral bending with a nondestructive stiffness method...
July 2004: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Robert Pflugmacher, Philipp Schleicher, Jan Schaefer, Matti Scholz, Kathrin Ludwig, Cyrus Khodadadyan-Klostermann, Norbert P Haas, Frank Kandziora
STUDY DESIGN: An in vitro biomechanical study of expandable cages for vertebral body replacement in the human thoracolumbar spine. OBJECTIVES: The purpose of this study was to compare the in vitro biomechanical properties of 3 different expandable cages with a nonexpandable cage. SUMMARY AND BACKGROUND DATA: Recently, there has been a rapid increase in the use and the commercial availability of expandable cages for vertebral body replacement in the thoracolumbar spine...
July 1, 2004: Spine
F Kandziora, R Pflugmacher, J Schäfer, C Born, G Duda, N P Haas, T Mittlmeier
STUDY DESIGN: An in vitro biomechanical study of cervical spine interbody fusion cages using a sheep model was conducted. OBJECTIVES: To evaluate the biomechanical effects of cervical spine interbody fusion cages, and to compare three different cage design groups. SUMMARY AND BACKGROUND DATA: Recently, there has been a rapid increase in the use of cervical spine interbody fusion cages as an adjunct to spondylodesis. These cages can be classified into three design groups: screw, box, or cylinder designs...
September 1, 2001: Spine
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