keyword
https://read.qxmd.com/read/38005993/characteristics-of-persistent-symptoms-manifested-after-sars-cov-2-vaccination-an-observational-retrospective-study-in-a-specialized-clinic-for-vaccination-related-adverse-events
#21
JOURNAL ARTICLE
Kazuki Tokumasu, Manami Fujita-Yamashita, Naruhiko Sunada, Yasue Sakurada, Koichiro Yamamoto, Yasuhiro Nakano, Yui Matsuda, Yuki Otsuka, Toru Hasegawa, Hideharu Hagiya, Hiroyuki Honda, Fumio Otsuka
Background: Although many adverse reactions after SARS-CoV-2 vaccination have been reported, there have been few comprehensive studies on persistent symptoms after SARS-CoV-2 vaccination. The aim of this study was to determine the clinical characteristics of patients with various persistent symptoms after SARS-CoV-2 vaccination. Methods: A retrospective descriptive study was performed for patients who visited a specialized clinic established at Okayama University Hospital to evaluate adverse events after SARS-CoV-2 vaccination during the period from April 2021 to March 2023...
October 30, 2023: Vaccines
https://read.qxmd.com/read/37999855/elevated-plasma-levels-of-specific-antiplatelet-glycoprotein-autoantibodies-in-patients-with-primary-sj%C3%A3-gren-syndrome-with-thrombocytopenia
#22
JOURNAL ARTICLE
Yingxin Ruan, Hongchen Bi, Xiaoli Luo, Aiming Pang, Pengyu Zhang, Yujie Cui
INTRODUCTION: Thrombocytopenia is one of the primary Sjögren's syndrome (pSS) hematological manifestations. The objective of this study was to evaluate the possible roles of antiplatelet glycoprotein autoantibodies in the pathogenesis of thrombocytopenia in primary Sjögren's syndrome (pSS). METHODS: The level of plasma anti-glycoprotein Ib, IIIa and IIb/IIIa autoantibodies in 36 pSS patients without thrombocytopenia and 35 pSS patients with thrombocytopenia, 36 Idiopathic thrombocytopenic purpura (ITP) patients and 39 normal control were measured with enzyme-linked immunosorbent assay (ELISA)...
November 24, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37980261/the-many-facets-of-immune-mediated-thrombocytopenia-principles-of-immunobiology-and-immunotherapy
#23
REVIEW
Thomas Moulinet, Anthony Moussu, Ludovic Pierson, Simona Pagliuca
Immune thrombocytopenia (ITP) is a rare autoimmune condition, due to peripheral platelet destruction through antibody-dependent cellular phagocytosis, complement-dependent cytotoxicity, cytotoxic T lymphocyte-mediated cytotoxicity, and megakaryopoiesis alteration. This condition may be idiopathic or triggered by drugs, vaccines, infections, cancers, autoimmune disorders and systemic diseases. Recent advances in our understanding of ITP immunobiology support the idea that other forms of thrombocytopenia, for instance, occurring after immunotherapy or cellular therapies, may share a common pathophysiology with possible therapeutic implications...
January 2024: Blood Reviews
https://read.qxmd.com/read/37799566/parallel-pathogens-coexistence-of-chickenpox-and-idiopathic-thrombocytopenic-purpura-a-case-report
#24
Abhigan Babu Shrestha, Anuj Yadav, Sadish Sharma, Unnat Hamal Sapkota, Mohamad Ali Farho, Md Moududul Islam, Md Ibn Abu Sayem, Md Nuruzzaman
This case report documents the unusual co-occurrence of immune thrombocytopena (ITP) and chickenpox in a 15-year-old girl. Initial symptoms included shortness of breath, chest pain, and heavy menstrual bleeding. Laboratory results revealed significant anemia and thrombocytopenia. Treatment involved blood transfusions, prednisolone, and iron supplementation. The patient's vesicular skin rash emerged 8 weeks later, prompting the combined diagnosis of ITP and chickenpox. Antiviral treatments, blood transfusions, and supportive care were used in the course of treatment, leading to full recovery...
October 2023: Clinical Case Reports
https://read.qxmd.com/read/37794676/-idiopathic-thrombocytopenia-purpura-after-pembrolizumab-treatment-against-locally-recurrent-bladder-cancer-a-case-report
#25
JOURNAL ARTICLE
Yuna Hattori, Manabu Kato, Tetsuya Imamura, Souta Inaba, Takashi Terabe, Momoko Kato, Shinichiro Higashi, Takeshi Sasaki, Satoru Masui, Yuko Yoshio, Kouhei Nishikawa, Katsunori Uchida, Takahiro Inoue
A man in his 70s visited our hospital for gross hematuria. He was diagnosed with invasive urothelial carcinoma (cT3N2M0) and underwent total cystectomy and ileum conduit construction after three courses of neoadjuvant chemotherapy. Eight months after the operation, the disease reoccurred in the pelvic lesion. He received pembrolizumab therapy but developed idiopathic thrombocytopenic purpura (ITP) immediately before the ninth course of administration; and, treatment was discontinued. Recovery of symptoms and normalization of blood test data were achieved 3...
September 2023: Hinyokika Kiyo. Acta Urologica Japonica
https://read.qxmd.com/read/37780929/thrombocytopenia-and-hyperthyroidism-a-case-report-and-literature-review
#26
Pitchaporn Yingchoncharoen, Mahmoud Abdelnabi, Jerapas Thongpiya, Alexandra Hoffman, Hira Tariq, Neha Mittal
KEY CLINICAL MESSAGE: Immune thrombocytopenic purpura (ITP) is very challenging to diagnose with concurrent comorbidities affecting platelet count including PAH and autoimmune thyroid disease. ITP resolution can be achieved with tailored treatment of the underlying conditions to avoid adverse events. ABSTRACT: Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a platelet count of <100 × 109 /L in the absence of other causes of thrombocytopenia...
October 2023: Clinical Case Reports
https://read.qxmd.com/read/37778762/safety-and-health-care-use-following-covid-19-vaccination-among-adults-with-rheumatoid-arthritis-a-population-based-self-controlled-case-series-analysis
#27
JOURNAL ARTICLE
Jennifer J Y Lee, Sasha Bernatsky, Jeffrey C Kwong, Qing Li, Timothy S H Kwok, Jessica Widdifield
OBJECTIVE: To determine if coronavirus disease 2019 (COVID-19) vaccines were associated with adverse events of special interest (AESIs) and healthcare use among adults with rheumatoid arthritis (RA). METHODS: Among adults with RA who received at least 1 COVID-19 vaccine, a self-controlled case series (SCCS) analysis was conducted to evaluate relative incidence (RI) rates of AESIs (Bell palsy, idiopathic thrombocytopenia, acute disseminated encephalomyelitis, pericarditis/myocarditis, Guillain-Barré syndrome, transverse myelitis, myocardial infarction, anaphylaxis, stroke, deep vein thrombosis, pulmonary embolism, narcolepsy, appendicitis, and disseminated intravascular coagulation) in any 21-day period following vaccination compared to control periods...
October 1, 2023: Journal of Rheumatology
https://read.qxmd.com/read/37778714/exploring-the-role-of-insulin-like-growth-factor-binding-protein-1-in-identifying-idiopathic-multicentric-castleman-s-disease-types-implications-for-the-mtor-signaling-pathway
#28
JOURNAL ARTICLE
Remi Sumiyoshi, Tomohiro Koga, Shoichi Fukui, Kaori Furukawa, Mamiko Momoki, Kunihiro Ichinose, Shingo Yano, Atsushi Kawakami
OBJECTIVE: To determine the molecular differences between iMCD-thrombocytopenia, anasarca, fevers, reticulin myelofibrosis, organomegaly (TAFRO), and iMCD-not otherwise specified (NOS). METHODS: CD4-positive T cells were isolated from two iMCD-TAFRO and two iMCD-NOS patients for RNA sequencing comparison. Serum proteins of two iMCD-TAFRO and four iMCD-NOS patients were comprehensively analyzed to identify pathogenesis-associated proteins. IGFBP-1 protein, extracted from serum analysis, was compared to healthy controls, iMCD, systemic lupus erythematosus, and rheumatoid arthritis patients...
September 30, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37746092/case-report-a-case-of-acute-exacerbation-of-interstitial-pneumonia-associated-with-tafro-syndrome
#29
Yoshitaka Shimada, Yasushi Nagaba, Mako Fujino, Hiroyuki Okawa, Kaori Ehara, Eri Shishido, Shinya Okada, Hiroaki Yokomori
Cytokine storm caused by the overproduction of inflammatory interleukin (IL)-6 plays a central role in the development of acute inflammation. The extremely rare disease, TAFRO syndrome, progresses quickly. Renal dysfunction, fever, reticulin fibrosis, anasarca, thrombocytopenia, and organomegaly with pathological findings such as idiopathic multicentric Castleman disease are all characteristics of TAFRO syndrome. Interstitial pneumonia (IP), which is not characteristic of this disease, is probably a complication of the inflammatory process...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37735546/pathogenesis-of-refractory-itp-overview
#30
REVIEW
Douglas B Cines
A subset of individuals with 'primary' or 'idiopathic' immune thrombocytopenia (ITP) who fail to respond to conventional first- and second-line agents or who lose responsiveness are considered to have 'refractory' disease (rITP), placing them at increased risk of bleeding and complications of intensive treatment. However, the criteria used to define the refractory state vary among studies, which complicates research and clinical investigation. Moreover, it is unclear whether rITP is simply 'more severe' ITP, or if there are specific pathogenic pathways that are more likely to result in refractory disease, and whether the presence or development of rITP can be established or anticipated based on these differences...
October 2023: British Journal of Haematology
https://read.qxmd.com/read/37724240/dengue-infection-triggering-concurrent-thrombotic-thrombocytopenic-purpura-in-a-case-of-chronic-idiopathic-thrombocytopenic-purpura
#31
Akash Rana, Prashant Ahlawat, Prateek Upadhyay, Akshita Gupta, Aman Bansal
We present a case report detailing the medical history of a 53-year-old female who had a well-established 10-year history of idiopathic thrombocytopenic purpura (ITP). The patient presented with fever and gum bleeding, prompting a series of laboratory investigations. These examinations revealed concurrent thrombocytopenia and hemolytic anemia, alongside a positive test result for serum dengue IgM antibodies. Initial treatment for the patient involved intravenous administration of glucocorticoids and intravenous immunoglobulin...
August 2023: Curēus
https://read.qxmd.com/read/37721182/a-retrospective-evaluation-of-phenobarbital-induced-hematologic-changes-in-69-cats
#32
JOURNAL ARTICLE
Anna Dohány, Abigail Guija-de-Arespacochaga, Daniela Fux, Christina Silberbauer, Ákos Pákozdy
BACKGROUND: Phenobarbital (PB) is used as a first-line treatment for recurrent epileptic seizures in cats. While hematologic abnormalities are well-known side effects of antiepileptic therapy with PB in humans and dogs, little is known about such alterations in cats. OBJECTIVES: The aim of this retrospective study was to investigate the prevalence and clinical relevance of cytopenia during PB treatment in cats. METHODS: In this single-center, retrospective clinical study, 69 cats-with suspected idiopathic epilepsy admitted to the Small Animal Clinic of the University of Veterinary Medicine in Vienna (VMU)-were included...
September 18, 2023: Veterinary Clinical Pathology
https://read.qxmd.com/read/37677880/transition-from-intravenous-epoprostenol-to-treprostinil-due-to-intolerable-side-effects-in-patients-with-pulmonary-arterial-hypertension
#33
JOURNAL ARTICLE
Hanako Kikuchi, Ayumi Goda, Kaori Takeuchi, Takumi Inami, Takashi Kohno, Kyoko Soejima, Toru Satoh
Intravenous epoprostenol improves exercise capacity and survival in patients with pulmonary arterial hypertension (PAH); however, it has side effects. Reviewing the side effects associated with epoprostenol and treprostinil is essential for improving the long-term treatment strategies for PAH. This retrospective review included patients with PAH who transitioned from intravenous epoprostenol to intravenous treprostinil owing to intolerable side effects, including high cardiac output symptoms, ascites, and thrombocytopenia...
November 1, 2023: American Journal of Cardiology
https://read.qxmd.com/read/37671127/thrombocytopenic-thromboembolic-and-haemorrhagic-events-following-second-dose-with-bnt162b2-and-chadox1-self-controlled-case-series-analysis-of-the-english-national-sentinel-cohort
#34
JOURNAL ARTICLE
Mark Joy, Utkarsh Agrawal, Xuejuan Fan, Chris Robertson, Sneha N Anand, Jose Ordonez-Mena, Rachel Byford, Rosalind Goudie, Gavin Jamie, Debasish Kar, John Williams, Gemma L Marsden, Victoria Tzortziou-Brown, Sir Aziz Sheikh, F D Richard Hobbs, Simon de Lusignan
BACKGROUND: Thrombosis associated with thrombocytopenia was a matter of concern post first and second doses of BNT162b2 and ChAdOx1 COVID-19 vaccines. Therefore, it is important to investigate the risk of thrombocytopenic, thromboembolic and haemorrhagic events following a second dose of BNT162b2 and ChAdOx1 COVID-19 vaccines. METHODS: We conducted a large-scale self-controlled case series analysis, using routine primary care data linked to hospital data, among 12...
September 2023: The Lancet regional health. Europe
https://read.qxmd.com/read/37667293/a-child-with-polyarthritis-and-chronic-lung-disease-a-case-report-of-ataxia-telangiectasia
#35
JOURNAL ARTICLE
Laura De Nardi, Marco Francesco Natale, Virginia Messia, Paolo Tomà, Fabrizio De Benedetti, Antonella Insalaco
BACKGROUND: Ataxia-telangiectasia (A-T) is a rare autosomal recessive DNA repair disorder, characterized by progressive cerebellar degeneration, telangiectasia, immunodeficiency, recurrent sinopulmonary infections, radiation sensitivity, premature aging and predisposition to cancer. Although the association with autoimmune and chronic inflammatory conditions such as vitiligo, thrombocytopenia and arthritis has occasionally been reported, an onset with articular involvement at presentation is rare...
September 4, 2023: Italian Journal of Pediatrics
https://read.qxmd.com/read/37656441/treatment-consistent-with-idiopathic-multicentric-castleman-disease-guidelines-is-associated-with-improved-outcomes
#36
JOURNAL ARTICLE
Sheila K Pierson, Megan S Lim, Gordan Srkalovic, Joshua D Brandstadter, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Natalie Mango, Criswell Lavery, Bridget Austin, Daisy Alapat, Mary Jo Lechowicz, Adam Bagg, Honzhe Li, Corey Casper, Frits van Rhee, David C Fajgenbaum
Idiopathic multicentric Castleman disease (iMCD) is a hematologic disorder with an unknown etiology that is diagnosed in approximately 1000-1200 individuals in the US annually. Clinical presentation is heterogeneous, ranging from mild constitutional symptoms with lymphadenopathy to life-threatening multi-organ dysfunction. International, consensus treatment guidelines were developed in 2018. These guidelines relied upon a limited number of clinical trials and small case series; however, real-world performance of these recommendations has not been subsequently studied...
September 1, 2023: Blood Advances
https://read.qxmd.com/read/37652172/punctate-inner-choroidopathy-in-common-variable-immunodeficiency-associated-with-a-pathogenic-variant-in-the-tumour-necrosis-factor-receptor-superfamily-13b-tnfrsf13b-gene-case-report-and-review-of-the-literature
#37
JOURNAL ARTICLE
Hiba Salih, Kelvin Cheng Kah Wai, Justin McKee, Charu Chopra
BACKGROUND: Common variable immunodeficiency (CVID) has been recognised as the most common primary immunodeficiency in adulthood, and is characterised by increased susceptibility to infection, autoimmunity and increased risk of malignancies. Although ocular manifestations are not common in CVID, rare associated inflammatory eye conditions have been reported including submacular choroiditis. OBJECTIVE: To report a case of punctate inner choroidopathy in a patient with common variable immunodeficiency...
August 29, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37648424/catch-up-vaccination-and-enhanced-immunization-against-hepatitis-b-hepatitis-a-measles-mumps-rubella-and-varicella-in-children-with-idiopathic-thrombocytopenic-purpura
#38
JOURNAL ARTICLE
Serçin Taşar, Medine Ayşin Taşar, Rukiye Ünsal Saç, Bülent Alioğlu
BACKGROUND: Limited data exist about the vaccination of children with idiopathic thrombocytopenic purpura (ITP) against vaccine preventable diseases. This study identified the vaccination status of children with ITP against hepatitis A, hepatitis B, measles, mumps, rubella and varicella, completed the immunization of children with inadequate immunization, re-evaluated post-vaccination antibody titers and identified probable vaccination-related complications. PATIENTS AND METHODS: All of 46 children had chronic ITP were included...
August 24, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37611541/complement-factor-i-gene-variant-in-an-atypical-hemolytic-uremic-syndrome-triggered-by-hypereosinophilia-syndrome
#39
Athiphat Banjongjit, Wonngarm Kittanamongkolchai, Talerngsak Kanjanabuch
Atypical hemolytic uremic syndrome (aHUS) is a condition characterized by acute kidney injury (AKI), thrombocytopenia, and microangiopathic hemolytic anemia (MAHA) secondary to complement pathway dysregulation. Several triggers have been identified as causing aHUS in genetically susceptible patients; however, hypereosinophilia syndrome (HES)-triggered aHUS has not been reported. In this article, we present a case of aHUS presented with generalized urticarial rashes and angioedema. The initial investigations revealed hypereosinophilia (maximal absolute eosinophil count of 6840 cells/µL) with normal bone-marrow analyses; hence, idiopathic HES was diagnosed...
August 23, 2023: Nephron
https://read.qxmd.com/read/37602041/a-novel-presentation-of-refractory-immune-thrombocytopenia-in-anti-synthetase-syndrome-a-case-report
#40
Robert D Nguyen, Hao H Tong, Siobán Keel
Anti-synthetase syndrome (AS) is a rare autoimmune disorder classified among the idiopathic inflammatory myopathies and is characterized by antibodies directed against aminoacyl-transfer RNA synthetases and the presence of myositis, interstitial lung disease, ±arthritis. Here, we report, for the first time, immune thrombocytopenia (ITP) in a patient with AS. This case reports a new association of AS with ITP and highlights the utility of identifying the underlying driver in secondary ITP to guide therapy...
July 2023: Curēus
keyword
keyword
5554
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.