Sheila K Pierson, Megan S Lim, Gordan Srkalovic, Joshua D Brandstadter, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Natalie Mango, Criswell Lavery, Bridget Austin, Daisy Alapat, Mary Jo Lechowicz, Adam Bagg, Honzhe Li, Corey Casper, Frits van Rhee, David C Fajgenbaum
Idiopathic multicentric Castleman disease (iMCD) is a hematologic disorder with an unknown etiology that is diagnosed in approximately 1000-1200 individuals in the US annually. Clinical presentation is heterogeneous, ranging from mild constitutional symptoms with lymphadenopathy to life-threatening multi-organ dysfunction. International, consensus treatment guidelines were developed in 2018. These guidelines relied upon a limited number of clinical trials and small case series; however, real-world performance of these recommendations has not been subsequently studied...
September 1, 2023: Blood Advances