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Thyroid disruptors

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https://www.readbyqxmd.com/read/28286098/hepatic-gene-expression-profiles-of-a-non-model-cyprinid-barbus-plebejus-chronically-exposed-to-river-sediments
#1
Nadia Casatta, Fabrizio Stefani, Luigi Viganò
In this study, we characterized the gene expression responses of the Padanian barbel (Barbus plebejus), a native benthivorous cyprinid with a very compromised presence within the fish community of the River Po. Barbel juveniles were exposed in the laboratory to two river sediments reflecting an upstream/downstream gradient of increasing contamination and collected from one of the most anthropized tributaries of the River Po. After 7months of exposure, hepatic transcriptional changes that were diagnostic of sediment exposure were assessed...
March 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28254054/re-evaluation-of-thyroid-hormone-signaling-antagonism-of-tetrabromobisphenol-a-for-validating-the-t3-induced-xenopus-metamorphosis-assay
#2
Yao Wang, Yuanyuan Li, Zhanfen Qin, Wuji Wei
We developed the T3-induced Xenopus metamorphosis assay, which is supposed to be able to sensitively detect thyroid hormone (TH) signaling disruption of chemicals. The present study aimed to validate the T3-induced Xenopus metamorphosis assay by re-evaluating the TH signaling antagonism of tetrabromobisphenol A (TBBPA), a known TH signaling disruptor. According to the assay we developed, Xenopus tadpoles at stage 52 were exposed to 10-500nmol/L TBBPA in the presence of 1nmol/L T3. After 96hr of exposure, TBBPA in the range of 10-500nmol/L was found to significantly inhibit T3-induced morphological changes of Xenopus tadpoles in a concentration-dependent manner in term of body weight and four morphological endpoints including head area (HA), mouth width (MW), unilateral brain width/brain length (ULBW/BL), and hind-limb length/snout-vent length (HLL/SVL)...
February 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28238262/cell-free-protein-synthesis-approach-to-biosensing-htr%C3%AE-specific-endocrine-disruptors
#3
Amin S M Salehi, Miriam J Shakalli Tang, Mark T Smith, Jeremy M Hunt, Robert A Law, David W Wood, Bradley C Bundy
Here we introduce a Rapid Adaptable Portable In vitro Detection biosensor platform (RAPID) for detecting ligands that interact with nuclear hormone receptors (NHRs). The RAPID platform can be adapted for field use, allowing rapid evaluation of endocrine disrupting chemicals (EDCs) presence or absence in environmental samples, and can also be applied for drug screening. The biosensor is based on an engineered, allosterically activated fusion protein, which contains the ligand binding domain from a target NHR (human thyroid receptor β in this work)...
March 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28146055/effects-of-gender-on-the-association-of-urinary-phthalate-metabolites-with-thyroid-hormones-in-children-a-prospective-cohort-study-in-taiwan
#4
Te-I Weng, Mei-Huei Chen, Guang-Wen Lien, Pai-Shan Chen, Jasper Chia-Cheng Lin, Cheng-Chung Fang, Pau-Chung Chen
Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles...
January 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28128023/hypothesis-driven-weight-of-evidence-analysis-of-endocrine-disruption-potential-a-case-study-with-triclosan
#5
Ellen Mihaich, Marie Capdevielle, Daniella Urbach-Ross, Brian Slezak
Triclosan is an antimicrobial agent used in a range of consumer products, such as deodorants, oral care, clothing, and household items. As with many consumer products, triclosan can be rinsed down the drain and transported to wastewater treatment plants. While most is eliminated during activated sludge sewage treatment by biodegradation and adsorption, some triclosan enters the aquatic environment and may expose wildlife. Given the potential for exposure to both humans and wildlife, resolving whether triclosan is endocrine active is important due to growing concerns about potential adverse public health and environmental effects of endocrine-disrupting substances...
January 27, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28065941/di2-ethylhexyl-phthalate-disrupts-thyroid-hormone-homeostasis-through-activating-the-ras-akt-trhr-pathway-and-inducing-hepatic-enzymes
#6
Hanfeng Ye, Mei Ha, Min Yang, Ping Yue, Zhengyuan Xie, Changjiang Liu
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063299/miniaturization-of-a-transthyretin-binding-assay-using-a-fluorescent-probe-for-high-throughput-screening-of-thyroid-hormone-disruption-in-environmental-samples
#7
Xiyu Ouyang, Jean Froment, Pim E G Leonards, Guttorm Christensen, Knut-Erik Tollefsen, Jacob de Boer, Kevin V Thomas, Marja H Lamoree
Thyroid hormone (TH) disrupting compounds are potentially important environmental contaminants due to their possible adverse neurological and developmental effects on both humans and wildlife. Currently, the most successful bio-analytical method to detect and evaluate TH disruptors, which target the plasma transport of TH in environmental samples, is the radio-ligand thyroxine-transthyretin (T4-TTR) binding assay. Yet, costly materials and tedious handling procedures prevent the use of this assay in high throughput analysis that is nowadays urgently demanded in environmental quality assessment...
December 23, 2016: Chemosphere
https://www.readbyqxmd.com/read/27993100/bisphenol-a-influences-oestrogen-and-thyroid-hormone-regulated-thyroid-hormone-receptor-expression-in-rat-cerebellar-cell-culture
#8
Virág Somogyi, Tamás L Horváth, István Tóth, Tibor Bartha, László Vilmos Frenyó, Dávid Sándor Kiss, Gergely Jócsák, Annamária Kerti, Frederick Naftolin, Attila Zsarnovszky
Thyroid hormones (THs) and oestrogens are crucial in the regulation of cerebellar development. TH receptors (TRs) mediate these hormone effects and are regulated by both hormone families. We reported earlier that THs and oestradiol (E2) determine TR levels in cerebellar cell culture. Here we demonstrate the effects of low concentrations (10(-10) M) of the endocrine disruptor (ED) bisphenol A (BPA) on the hormonal (THs, E2) regulation of TRα,β in rat cerebellar cell culture. Primary cerebellar cell cultures, glia-containing and glia-destroyed, were treated with BPA or a combination of BPA and E2 and/or THs...
December 2016: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/27979590/development-of-a-screening-approach-to-detect-thyroid-disrupting-chemicals-that-inhibit-the-human-sodium-iodide-symporter-nis
#9
Daniel R Hallinger, Ashley S Murr, Angela R Buckalew, Steven O Simmons, Tammy E Stoker, Susan C Laws
The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals that may disrupt the thyroid signaling pathway. Thyroid hormone biosynthesis requires active iodide uptake mediated by the sodium/iodide symporter (NIS). Monovalent anions, such as the environmental contaminant perchlorate, are competitive inhibitors of NIS, yet limited information exists for more structurally diverse chemicals. A novel cell line expressing human NIS, hNIS-HEK293T-EPA, was used in a radioactive iodide uptake (RAIU) assay to identify inhibitors of NIS-mediated iodide uptake...
December 12, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27916585/perinatal-exposure-to-glyphosate-based-herbicide-alters-the-thyrotrophic-axis-and-causes-thyroid-hormone-homeostasis-imbalance-in-male-rats
#10
Janaina Sena de Souza, Marina Malta Letro Kizys, Rodrigo Rodrigues da Conceição, Gabriel Glebocki, Renata Marino Romano, Tania Maria Ortiga-Carvalho, Gisele Giannocco, Ismael Dale Cotrim Guerreiro da Silva, Magnus Regios Dias da Silva, Marco Aurélio Romano, Maria Izabel Chiamolera
Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Female pregnant Wistar rats were exposed to a solution containing GBH Roundup(®)Transorb (Monsanto). The animals were divided into three groups (control, 5mg/kg/day or 50mg/kg/day) and exposed from gestation day 18 (GD18) to post-natal day 5 (PND5)...
February 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#11
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27837466/thyroid-disruption-by-perfluorooctane-sulfonate-pfos-and-perfluorooctanoate-pfoa
#12
REVIEW
F Coperchini, O Awwad, M Rotondi, F Santini, M Imbriani, L Chiovato
BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are two fluorinated compounds widely used in industry because of their useful chemical characteristics. They were identified as endocrine disruptors due to their ability to interfere with thyroid function. The resistance of PFOA and PFOS to environmental degradation, their bio-accumulation in food chains, and their long half-life raised concern in the scientific community, and several studies were performed with the aim to establish the real dangerousness of these compounds for the human health...
February 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27794445/heavy-metals-in-the-volcanic-environment-and-thyroid-cancer
#13
R Vigneri, P Malandrino, F Gianì, M Russo, P Vigneri
In the last two decades thyroid cancer incidence has increased worldwide more than any other cancer. Overdiagnosis of subclinical microcarcinomas has certainly contributed to this increase but many evidences indicate that a true increase, possibly due to environmental factors, has also occurred. Thyroid cancer incidence is markedly increased in volcanic areas. Thus, the volcanic environment is a good model to investigate the possible factors favoring thyroid cancer. In the volcanic area of Mt. Etna in Sicily, as well as in other volcanic areas, a non-anthropogenic pollution with heavy metals has been documented, a consequence of gas, ash and lava emission...
October 26, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27768855/population-survey-of-iodine-deficiency-and-environmental-disruptors-of-thyroid-function-in-young-children-in-haiti
#14
Julia Elisabeth von Oettingen, Tesha Dawn Brathwaite, Christopher Carpenter, Ric Bonnell, Xuemei He, Lewis E Braverman, Elizabeth N Pearce, Philippe Larco, Nancy Charles Larco, Eddy Jean-Baptiste, Rosalind S Brown
CONTEXT: Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide. It is a possible public health concern in Haiti. OBJECTIVE: To perform a population iodine survey in Haitian young children, and its influence by environmental factors. DESIGN: Cross-sectional study, March-June 2015. SETTING: Community churches in 3 geographical regions in Haiti. PARTICIPANTS: 299 healthy Haitian children aged 9 months to 6 years; 100 enrolled in coastal (C) and mountainous (M) regions, and 99 in an urban region (U)...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27755165/do-flame-retardant-chemicals-increase-the-risk-for-thyroid-dysregulation-and-cancer
#15
Kate Hoffman, Julie A Sosa, Heather M Stapleton
PURPOSE OF REVIEW: Flame retardant chemicals are added to consumer products to reduce fire incidence and severity; approximately 1.5 million tons of these chemicals are used annually. However, their widespread use has led to their ubiquitous presence in the environment and chronic accumulation in human tissues. We summarize current trends in human flame retardant chemical exposure, and review recent data highlighting concerns for thyroid dysregulation and cancer risk in human populations...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27737548/identification-of-thyroid-hormone-disruptors-among-ho-pbdes-in-vitro-investigations-and-coregulator-involved-simulations
#16
Qinchang Chen, Xiaoxiang Wang, Wei Shi, Hongxia Yu, Xiaowei Zhang, John P Giesy
Some hydroxylated polybrominated diphenyl ethers (HO-PBDEs), that have been widely detected in the environment and tissues of humans and wildlife, bind to thyroid hormone (TH) receptor (TR) and can disrupt functioning of systems modulated by the TR. However, mechanisms of TH disrupting effects are still equivocal. Here, disruption of functions of TH modulated pathways by HO-PBDEs was evaluated by assays of competitive binding, coactivator recruitment, and proliferation of GH3 cells. In silico simulations considering effects of coregulators were carried out to investigate molecular mechanisms and to predict potencies for disrupting functions of the TH...
November 15, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27734692/-levothyroxine-therapy-factors-influencing-its-outcome
#17
Marcela Dvořáková
The article gives an overview of the circumstances-eating habits, disorders of absorption in the intestinal and other disease, certain drugs and substances occurring in nature affecting the metabolism of thyroid hormones on many levels, thyroid disruptors, for which compensation may be healing broken thyroid function to be unsatisfactory in spite of following the rules of substitution treatment. Knowledge of these conditions and adapting to them timely by adjusting either the eating habits or thyroid hormone by adjusting benefits, allowing the patient to improve his subjective feelings from treatment and improving compliance...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27589887/identifying-reference-chemicals-for-thyroid-bioactivity-screening
#18
Susanna Wegner, Patience Browne, David Dix
Reference chemicals were selected based on thyroid bioactivity in 'Tier 1' screening assays used by the U.S. EPA's Endocrine Disruptor Screening Program. Active reference chemicals had significant effects on thyroid-responsive endpoints in the amphibian metamorphosis assay, and the male and female pubertal rat assays. In the absence of thyroid weight or histopathological effects, additional published studies providing mechanistic data on thyroid activity were required for active chemicals. Inactive reference chemicals had no significant effects on thyroid-responsive endpoints in Tier 1 assays, or in amphibian or rodent studies from several online databases...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27544454/development-of-yeast-reporter-assays-for-the-enhanced-detection-of-environmental-ligands-of-thyroid-hormone-receptors-%C3%AE-and-%C3%AE-from-xenopus-tropicalis
#19
Satoko Matsui, Sayoko Ito-Harashima, Yuji Sugimoto, Eiji Takada, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
Thyroid hormones (THs) are involved in the regulation of metabolic homeostasis during the development and differentiation of vertebrates, particularly amphibian metamorphosis, which is entirely controlled by internal TH levels. Some artificial chemicals have been shown to exhibit TH-disrupting activities. In order to detect TH disruptors for amphibians, we herein developed a reporter assay using yeast strains expressing the thyroid hormone receptors (TRs) α and β together with the transcriptional coactivator SRC-1, all of which were derived from the frog Xenopus tropicalis (XT)...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27538710/phenotypically-anchored-transcriptome-profiling-of-developmental-exposure-to-the-antimicrobial-agent-triclosan-reveals-hepatotoxicity-in-embryonic-zebrafish
#20
Derik E Haggard, Pamela D Noyes, Katrina M Waters, Robert L Tanguay
Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen signaling; therefore, research examining the developmental effects of TCS is warranted. In this study, we used embryonic zebrafish to investigate the developmental toxicity and potential mechanism of action of TCS...
October 1, 2016: Toxicology and Applied Pharmacology
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