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Thyroid disruptors

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https://www.readbyqxmd.com/read/27916585/perinatal-exposure-to-glyphosate-based-herbicide-alters-the-thyrotrophic-axis-and-causes-thyroid-hormone-homeostasis-imbalance-in-male-rats
#1
Janaina Sena de Souza, Marina Malta Letro Kizys, Rodrigo Rodrigues da Conceição, Gabriel Glebocki, Renata Marino Romano, Tania Maria Ortiga-Carvalho, Gisele Giannocco, Ismael Dale Cotrim Guerreiro da Silva, Magnus Regios Dias da Silva, Marco Aurélio Romano, Maria Izabel Chiamolera
Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Female pregnant Wistar rats were exposed to a solution containing GBH Roundup(®)Transorb (Monsanto). The animals were divided into three groups (control, 5mg/kg/day or 50mg/kg/day) and exposed from gestation day 18 (GD18) to post-natal day 5 (PND5)...
December 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#2
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27837466/thyroid-disruption-by-perfluorooctane-sulfonate-pfos-and-perfluorooctanoate-pfoa
#3
REVIEW
F Coperchini, O Awwad, M Rotondi, F Santini, M Imbriani, L Chiovato
BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are two fluorinated compounds widely used in industry because of their useful chemical characteristics. They were identified as endocrine disruptors due to their ability to interfere with thyroid function. The resistance of PFOA and PFOS to environmental degradation, their bio-accumulation in food chains, and their long half-life raised concern in the scientific community, and several studies were performed with the aim to establish the real dangerousness of these compounds for the human health...
November 11, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27794445/heavy-metals-in-the-volcanic-environment-and-thyroid-cancer
#4
R Vigneri, P Malandrino, F Gianì, M Russo, P Vigneri
In the last two decades thyroid cancer incidence has increased worldwide more than any other cancer. Overdiagnosis of subclinical microcarcinomas has certainly contributed to this increase but many evidences indicate that a true increase, possibly due to environmental factors, has also occurred. Thyroid cancer incidence is markedly increased in volcanic areas. Thus, the volcanic environment is a good model to investigate the possible factors favoring thyroid cancer. In the volcanic area of Mt. Etna in Sicily, as well as in other volcanic areas, a non-anthropogenic pollution with heavy metals has been documented, a consequence of gas, ash and lava emission...
October 26, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27768855/population-survey-of-iodine-deficiency-and-environmental-disruptors-of-thyroid-function-in-young-children-in-haiti
#5
Julia Elisabeth von Oettingen, Tesha Dawn Brathwaite, Christopher Carpenter, Ric Bonnell, Xuemei He, Lewis E Braverman, Elizabeth N Pearce, Philippe Larco, Nancy Charles Larco, Eddy Jean-Baptiste, Rosalind S Brown
CONTEXT: Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide. It is a possible public health concern in Haiti. OBJECTIVE: To perform a population iodine survey in Haitian young children, and its influence by environmental factors. DESIGN: Cross-sectional study, March-June 2015. SETTING: Community churches in 3 geographical regions in Haiti. PARTICIPANTS: 299 healthy Haitian children aged 9 months to 6 years; 100 enrolled in coastal (C) and mountainous (M) regions, and 99 in an urban region (U)...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27755165/do-flame-retardant-chemicals-increase-the-risk-for-thyroid-dysregulation-and-cancer
#6
Kate Hoffman, Julie A Sosa, Heather M Stapleton
PURPOSE OF REVIEW: Flame retardant chemicals are added to consumer products to reduce fire incidence and severity; approximately 1.5 million tons of these chemicals are used annually. However, their widespread use has led to their ubiquitous presence in the environment and chronic accumulation in human tissues. We summarize current trends in human flame retardant chemical exposure, and review recent data highlighting concerns for thyroid dysregulation and cancer risk in human populations...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27737548/identification-of-thyroid-hormone-disruptors-among-ho-pbdes-in-vitro-investigations-and-co-regulator-involved-simulations
#7
Qinchang Chen, Xiaoxiang Wang, Wei Shi, Hongxia Yu, Xiaowei Zhang, John P Giesy
Some hydroxylated polybrominated diphenyl ethers (HO-PBDEs), that have been widely detected in the environment and tissues of humans and wildlife, bind to thyroid hormone (TH) receptor (TR) and can disrupt functioning of systems modulated by the TR. However, the mechanism of TH disrupting effect is still equivocal. Here, disruption of functions of TH modulated pathways by HO-PBDEs were evaluated by use of assays of competitive binding, coactivator recruitment and proliferation of GH3 cells. In silico simulations considering effects of co-regulators were carried out to investigate molecular mechanisms and predict potencies for disrupting functions of the TH...
October 14, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27734692/-levothyroxine-therapy-factors-influencing-its-outcome
#8
Marcela Dvořáková
The article gives an overview of the circumstances-eating habits, disorders of absorption in the intestinal and other disease, certain drugs and substances occurring in nature affecting the metabolism of thyroid hormones on many levels, thyroid disruptors, for which compensation may be healing broken thyroid function to be unsatisfactory in spite of following the rules of substitution treatment. Knowledge of these conditions and adapting to them timely by adjusting either the eating habits or thyroid hormone by adjusting benefits, allowing the patient to improve his subjective feelings from treatment and improving compliance...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27589887/identifying-reference-chemicals-for-thyroid-bioactivity-screening
#9
Susanna Wegner, Patience Browne, David Dix
Reference chemicals were selected based on thyroid bioactivity in 'Tier 1' screening assays used by the U.S. EPA's Endocrine Disruptor Screening Program. Active reference chemicals had significant effects on thyroid-responsive endpoints in the amphibian metamorphosis assay, and the male and female pubertal rat assays. In the absence of thyroid weight or histopathological effects, additional published studies providing mechanistic data on thyroid activity were required for active chemicals. Inactive reference chemicals had no significant effects on thyroid-responsive endpoints in Tier 1 assays, or in amphibian or rodent studies from several online databases...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27544454/development-of-yeast-reporter-assays-for-the-enhanced-detection-of-environmental-ligands-of-thyroid-hormone-receptors-%C3%AE-and-%C3%AE-from-xenopus-tropicalis
#10
Satoko Matsui, Sayoko Ito-Harashima, Yuji Sugimoto, Eiji Takada, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
Thyroid hormones (THs) are involved in the regulation of metabolic homeostasis during the development and differentiation of vertebrates, particularly amphibian metamorphosis, which is entirely controlled by internal TH levels. Some artificial chemicals have been shown to exhibit TH-disrupting activities. In order to detect TH disruptors for amphibians, we herein developed a reporter assay using yeast strains expressing the thyroid hormone receptors (TRs) α and β together with the transcriptional coactivator SRC-1, all of which were derived from the frog Xenopus tropicalis (XT)...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27538710/phenotypically-anchored-transcriptome-profiling-of-developmental-exposure-to-the-antimicrobial-agent-triclosan-reveals-hepatotoxicity-in-embryonic-zebrafish
#11
Derik E Haggard, Pamela D Noyes, Katrina M Waters, Robert L Tanguay
Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen signaling; therefore, research examining the developmental effects of TCS is warranted. In this study, we used embryonic zebrafish to investigate the developmental toxicity and potential mechanism of action of TCS...
October 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27502899/mechanisms-of-arsenic-disruption-on-gonadal-adrenal-and-thyroid-endocrine-systems-in-humans-a-review
#12
REVIEW
Hong-Jie Sun, Ping Xiang, Jun Luo, Huachang Hong, Hongjun Lin, Hong-Bo Li, Lena Q Ma
Due to its toxicity as a carcinogen and wide distribution in the environment, arsenic (As) exposure in humans is of public concern globally. Many studies have manifested that As exposure induces cancers besides pathological effects in humans. Animal studies showed that chronic As exposure induces serious neurological effects. Based on recent studies, researchers proposed that As, including arsenate (AsV) and arsenite (AsIII), is also an endocrine disruptor. This review discusses the mechanisms of As toxicity on three endocrine systems including gonadal, adrenal and thyroid endocrine systems...
October 2016: Environment International
https://www.readbyqxmd.com/read/27448730/phenols-and-parabens-in-relation-to-reproductive-and-thyroid-hormones-in-pregnant-women
#13
Amira M Aker, Deborah J Watkins, Lauren E Johns, Kelly K Ferguson, Offie P Soldin, Liza V Anzalota Del Toro, Akram N Alshawabkeh, José F Cordero, John D Meeker
INTRODUCTION: Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, "Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)". METHODS: Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16-20 weeks and 24-28 weeks)...
November 2016: Environmental Research
https://www.readbyqxmd.com/read/27410513/identification-and-molecular-interaction-studies-of-thyroid-hormone-receptor-disruptors-among-household-dust-contaminants
#14
Jin Zhang, Yaozong Li, Arun A Gupta, Kwangho Nam, Patrik L Andersson
Thyroid hormone disrupting chemicals (THDCs), often found abundantly in the environment, interfere with normal thyroid hormone signaling and induce physiological malfunctions, possibly by affecting thyroid hormone receptors (THRs). Indoor dust ingestion is a significant human exposure route of THDCs, raising serious concerns for human health. Here, we developed a virtual screening protocol based on an ensemble of X-ray crystallographic structures of human THRβ1 and the generalized Born solvation model to identify potential THDCs targeting the human THRβ1 isoform...
August 15, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27383240/perchlorate-exposure-reduces-primordial-germ-cell-number-in-female-threespine-stickleback
#15
Ann M Petersen, Nathanial C Earp, Mandy E Redmond, John H Postlethwait, Frank A von Hippel, C Loren Buck, William A Cresko
Perchlorate is a common aquatic contaminant that has long been known to affect thyroid function in vertebrates, including humans. More recently perchlorate has been shown to affect primordial sexual differentiation in the aquatic model fishes zebrafish and threespine stickleback, but the mechanism has been unclear. Stickleback exposed to perchlorate from fertilization have increased androgen levels in the embryo and disrupted reproductive morphologies as adults, suggesting that perchlorate could disrupt the earliest stages of primordial sexual differentiation when primordial germ cells (PGCs) begin to form the gonad...
2016: PloS One
https://www.readbyqxmd.com/read/27347635/a-predictive-data-driven-framework-for-endocrine-prioritization-a-triazole-fungicide-case-study
#16
Katie Paul Friedman, Sabitha Papineni, M Sue Marty, Kun Don Yi, Amber K Goetz, Reza J Rasoulpour, Pat Kwiatkowski, Douglas C Wolf, Ann M Blacker, Richard C Peffer
The US Environmental Protection Agency Endocrine Disruptor Screening Program (EDSP) is a tiered screening approach to determine the potential for a chemical to interact with estrogen, androgen, or thyroid hormone systems and/or perturb steroidogenesis. Use of high-throughput screening (HTS) to predict hazard and exposure is shifting the EDSP approach to (1) prioritization of chemicals for further screening; and (2) targeted use of EDSP Tier 1 assays to inform specific data needs. In this work, toxicology data for three triazole fungicides (triadimefon, propiconazole, and myclobutanil) were evaluated, including HTS results, EDSP Tier 1 screening (and other scientifically relevant information), and EPA guideline mammalian toxicology study data...
October 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27344267/association-between-organochlorine-pesticide-exposure-and-thyroid-hormones-in-floriculture-workers
#17
Julia Blanco-Muñoz, Marina Lacasaña, Inmaculada López-Flores, Miguel Rodríguez-Barranco, Beatriz González-Alzaga, Susana Bassol, Mariano E Cebrian, Lizbeth López-Carrillo, Clemente Aguilar-Garduño
Several studies have suggested that exposure to DDT may be related to changes in thyroid hormone levels in animals and humans, even though results across studies are inconsistent. The aim of this study was to assess the association between exposure to p,p'-DDE (a stable metabolite of DDT) and serum levels of thyroid hormones in floriculture workers. A longitudinal study was conducted on 136 male subjects from the States of Mexico and Morelos, Mexico, who were occupationally exposed to pesticides, during agricultural periods of high (rainy season) and low (dry season) levels of pesticide application...
October 2016: Environmental Research
https://www.readbyqxmd.com/read/27331295/epidemiological-trends-of-hormone-related-cancers-in-slovenia
#18
Vesna Zadnik, Mateja Krajc
The incidence of hormone-related cancers tends to be higher in the developed world than in other countries. In Slovenia, six hormone-related cancers (breast, ovarian, endometrial, prostate, testicular, and thyroid) account for a quarter of all cancers. Their incidence goes up each year, breast and prostate cancer in particular. The age at diagnosis is not decreasing for any of the analysed cancer types. The risk of breast cancer is higher in the western part of the country, but no differences in geographical distribution have been observed for other hormone-related cancers...
June 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27327272/profiling-of-vitamin-d-metabolic-intermediates-toward-vdr-using-novel-stable-gene-reporter-cell-lines-iz-vdre-and-iz-cyp24
#19
Iveta Bartonkova, Aneta Grycova, Zdenek Dvorak
Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Therefore, it is of topical interest to have reliable and efficient in vitro screening tools for the identification of agonists and activators of human VDR. We present here two novel stably transfected human reporter cell lines allowing rapid, high-throughput, and selective identification of VDR agonists and activators...
July 18, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27285165/exposure-to-endocrine-disrupting-chemicals-and-neurodevelopmental-alterations
#20
REVIEW
A Pinson, J P Bourguignon, A S Parent
The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to the effects of endocrine-disrupting chemicals (EDCs) during critical periods of development. This review focuses on three ubiquitous endocrine disruptors that are known to disrupt the thyroid function and are associated with neurobehavioral deficits: polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A...
July 2016: Andrology
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