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https://www.readbyqxmd.com/read/29350498/glioma-targeted-delivery-of-a-theranostic-liposome-integrated-with-quantum-dots-superparamagnetic-iron-oxide-and-cilengitide-for-dual-imaging-guiding-cancer-surgery
#1
He-Lin Xu, Jing-Jing Yang, De-Li ZhuGe, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Meng-Qi Tong, Bi-Xin Shen, Jian Xiao, Ying-Zheng Zhao
Herein, a theranostic liposome (QSC-Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X-ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29349918/dual-drug-backboned-shattering-polymeric-theranostic-nanomedicine-for-synergistic-eradication-of-patient-derived-lung-cancer
#2
Yuwei Cong, Haihua Xiao, Hejian Xiong, Zigui Wang, Jianxun Ding, Chan Li, Xuesi Chen, Xing-Jie Liang, Dongfang Zhou, Yubin Huang
Most of the current nanoparticle-based therapeutics worldwide failing in clinical trials face three major challenges: (i) lack of an optimum drug delivery platform with precise composition, (ii) lack of a method of directly monitoring the fate of a specific drug rather than using any other labelling molecules as a compromise, and (iii) lack of reliable cancer models with high fidelity for drug screen and evaluation. Here, starting from a PP2A inhibitor demethylcantharidin (DMC) and cisplatin, the design of a dual sensitive dual drug backboned shattering polymer (DDBSP) with exact composition at a fixed DMC/Pt ratio for precise nanomedicine is shown...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29349469/dopant-dependent-crystallization-and-photothermal-effect-of-sb-doped-sno2-nanoparticles-as-stable-theranostic-nanoagents-for-tumor-ablation
#3
Nuo Yu, Chen Peng, Zhaojie Wang, Zixiao Liu, Bo Zhu, Zhigao Yi, Meifang Zhu, Xiaogang Liu, Zhigang Chen
Ideal theranostic nanoagents should be "all-in-one" type nanocrystals that have a single-semiconductor component and all-required properties (such as imaging and photothermal effects), but most semiconductor nanocrystals do not have these required properties. With SnO2 as a model of a typical wide-band semiconductor, we report the tuning from UV-responsive SnO2 to blue SnO2 nanocrystals with imaging ability and a Sb-doping-dependent photothermal effect. Sb-Doped SnO2 nanocrystals were prepared by heating SbCl3 and SnCl4 in benzyl alcohol solution through a facile solvothermal route...
January 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29348802/fluorescent-carbon-nanoparticles-in-medicine-for-cancer-therapy-an-update
#4
EDITORIAL
Reshma Rani, Vinit Kumar, Flavio Rizzolio
In the past few years since our viewpoint on carbon nanoparticles was first published in 2013 (Kumar, V.; Toffoli, G.; Rizzolio, F. ACS Med. Chem. Lett.2013, 4 (11), 1012-1013), a considerable progress has been made in the area of synthesis, functionalization, and applications of fluorescent carbon nanoparticles (CNPs). This update aims to highlight some key points achieved in the last 4 years in the development of CNPs with a particular emphasis on the approaches to ameliorate clinical applications of CNPs as therapeutics, diagnostics, and theranostics agents...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348316/evaluation-of-next-generation-anti-cd20-antibodies-labeled-with-zirconium-89-in-human-lymphoma-xenografts
#5
Jason T Yoon, Mark S Longtine, Bernadette V Marquez-Nostra, Richard L Wahl
Radioimmunotherapies with monoclonal antibodies (mAbs) to the B-lymphocyte antigen 20 (CD20) are effective treatments for B-cell lymphomas, but United States Food and Drug Administration (FDA)-approved radioimmunotherapies exclusively use radiolabeled murine antibodies, potentially limiting re-dosing. The FDA recently approved two unlabeled anti-CD20 monoclonal antibodies, obinutizumab and ofatumumab, termed "next generation" as they are humanized (obinituzumab) or fully human (ofatumumab), thus potentially allowing a greater potential for re-dosing than with previous generation anti-CD20 antibodies, including rituximab (chimeric) and tositumumab (murine) which contain more murine peptide sequences...
January 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29345211/developing-single-entity-theranostic-drug-based-fluorescent-nanoclusters-with-augmented-cytotoxicity
#6
Bandhan Chatterjee, Asif Raza, Siddhartha Sankar Ghosh
AIM: To develop methotrexate (MTX) templated luminescent gold nanoclusters (NCs) as a single unit nanotheranostic for cancer therapy and to assess its potential as an alternative to the parent drug, for drug delivery vehicles (DDVs). METHODS: Theranostics were synthesized and extensively characterized. The stability of the theranostic and its bioimaging aptitude were evaluated. The antiproliferative propensity of the theranostic was gauged with cell viability assays and was supplemented with cytometry-based assays...
January 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29344592/ph-responsible-fluorescent-carbon-nanoparticles-for-tumor-selective-theranostics-via-ph-turn-on-off-fluorescence-and-photothermal-effect-in-vivo-and-in-vitro
#7
Eun Bi Kang, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Insik In, Ji Hoon Jeong, Sung Young Park
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable photothermal therapy (PTT) in vivo and in vitro. The fluorescent "off" of FNP-I was activated after reaching the cancer cell environment, where the zwitterionic compartment of FNP lost its hydrophobicity to induce PTT-mediated heat release of IR825 under NIR irradiation in the tumor...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29344308/-albumin-hitchhiking-with-an-evans-blue-analog-for-cancer-theranostics
#8
EDITORIAL
Emily B Ehlerding, Xiaoli Lan, Weibo Cai
Although 177Lu-DOTA-TATE was recently approved in Europe for the treatment of certain neuroendocrine tumors, continued development and optimization has been ongoing to further improve the therapeutic efficacy of somatostatin receptor 2 targeted peptide receptor radionuclide therapy, as well as reducing the renal toxicity. In this work, the use of an Evans blue analog for "albumin hitchhiking" resulted in significant improvement in both the imaging performance and therapeutic efficacy of radiolabeled octreotate, as well as reducing the toxicity since much less radioactivity was used for therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#9
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344305/a-tumor-activatable-theranostic-nanomedicine-platform-for-nir-fluorescence-guided-surgery-and-combinatorial-phototherapy
#10
Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344301/wst11-vascular-targeted-photodynamic-therapy-effect-monitoring-by-multispectral-optoacoustic-tomography-msot-in-mice
#11
Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A Coleman, Moritz F Kircher, Vasilis Ntziachristos
Objective: Monitoring emerging vascular-targeted photodynamic therapy (VTP) and understanding the time-dynamics of treatment effects remains challenging. We interrogated whether handheld multispectral optoacoustic tomography (MSOT) could noninvasively monitor the effect of VTP using WST11, a vascular-acting photosensitizer, on tumor tissues over time using a renal cell cancer mouse model. We also investigated whether MSOT illumination can induce VTP, to implement a single-modality theranostic approach. Materials and Methods: Eight BalB/c mice were subcutaneously implanted with murine renal adenocarcinoma cells (RENCA) on the flank...
2018: Theranostics
https://www.readbyqxmd.com/read/29344297/mesoporous-carbon-nanospheres-as-a-multifunctional-carrier-for-cancer-theranostics
#12
Libo Zhou, Ying Jing, Yubin Liu, Zhihe Liu, Duyang Gao, Haobin Chen, Weiye Song, Tao Wang, Xiaofeng Fang, Weiping Qin, Zhen Yuan, Sheng Dai, Zhen-An Qiao, Changfeng Wu
Optical nanomaterials with intense absorption in near-infrared (NIR) region hold great promise for biomedical applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). In this work, we report mesoporous carbon nanospheres (Meso-CNs) with broadband and intense absorption in the UV-Vis-NIR region (300-1400 nm) and explore their potential as a multifunctional platform for photoacoustic imaging and chemo-photothermal therapy. Methods: Meso-CNs were prepared by a "silica-assisted" synthesis strategy and characterized by transmission electron microscope and optical spectroscopy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344129/update-on-radionuclide-therapy-in-oncology
#13
Cornelia Nitipir, Dana Niculae, Cristina Orlov, Maria Alexandra Barbu, Bogdan Popescu, Ana Maria Popa, Anca Mihaela Stoian Pantea, Adina Elena Stanciu, Bianca Galateanu, Octav Ginghina, Georgios Z Papadakis, Boris N Izotov, Demetrios A Spandidos, Aristides M Tsatsakis, Carolina Negrei
Unstable isotopes and their capacity to emit ionizing radiation have been employed in clinical practice not only for diagnostic, but also for therapeutic purposes, with significant contribution in several fields of medicine and primarily in the management of oncologic patients. Their efficacy is associated with their ability to provide the targeted delivery of ionizing radiation for a determined duration. These compounds can be used for curative or palliative treatment, as well as for a diagnostic-therapeutic (theranostic) approach...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29342965/lipid-based-nanoparticles-as-a-potential-delivery-approach-in-the-treatment-of-rheumatoid-arthritis
#14
REVIEW
Shih-Yi Chuang, Chih-Hung Lin, Tse-Hung Huang, Jia-You Fang
Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, nanoparticles, which are capable of encapsulating and protecting drugs from degradation before they reach the target site in vivo, may serve as drug delivery systems...
January 15, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29341227/pet-radiometals-for-antibody-labeling
#15
Eduardo Aluicio-Sarduy, Paul A Ellison, Todd E Barnhart, Weibo Cai, Robert Jerry Nickles, Jonathan W Engle
Recent advances in molecular characterization of tumors have made possible the emergence of new types of cancer therapies where the traditional cytotoxic drugs and nonspecific chemotherapy can be complemented with targeted molecular therapies. One of the main revolutionary treatments is the use of monoclonal antibodies (mAbs) that selectively target the disseminated tumor cells while sparing normal tissues. mAbs and related therapeutics can be efficiently radiolabeled with a wide range of radionuclides to facilitate preclinical and clinical studies...
January 17, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29341024/advanced-contrast-agents-for-multimodal-biomedical-imaging-based-on-nanotechnology
#16
Daniel Calle, Paloma Ballesteros, Sebastián Cerdán
Clinical imaging modalities have reached a prominent role in medical diagnosis and patient management in the last decades. Different image methodologies as Positron Emission Tomography, Single Photon Emission Tomography, X-Rays, or Magnetic Resonance Imaging are in continuous evolution to satisfy the increasing demands of current medical diagnosis. Progress in these methodologies has been favored by the parallel development of increasingly more powerful contrast agents. These are molecules that enhance the intrinsic contrast of the images in the tissues where they accumulate, revealing noninvasively the presence of characteristic molecular targets or differential physiopathological microenvironments...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29341020/mri-in-the-study-of-animal-models-of-stroke
#17
Pedro Ramos-Cabrer, Daniel Padro
Stroke consists of the loss of cerebral functions resulting from the interruption of blood supply to a region of the brain, and represents the second cause of death and the leading cause of major disability in adults in Europe. Stroke is a very active field of research at preclinical and clinical levels, and Magnetic Resonance Imaging (MRI) is one of the most powerful tools that scientist and clinicians have for the study of the onset, evolution and consequences of this devastating disease, as well as for the monitoring of the success of available treatments, or for the development of novel therapeutic strategies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29338452/an-update-on-diagnostic-and-prognostic-biomarkers-for-traumatic-brain-injury
#18
Kevin K Wang, Zhihui Yang, Tian Zhu, Yuan Shi, Richard Rubenstein, J Adrian Tyndall, Geoff T Manley
Traumatic brain injury (TBI) is a major worldwide neurological disorder of epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms of TBI. Encouragingly, there are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome. Area covered: The authors provide an update on the current knowledge of TBI biomarkers, including protein biomarkers for neuronal cell body injury (UCH-L1, NSE), astroglial injury (GFAP, S100B), neuronal cell death (αII-spectrin breakdown products), axonal injury (NF proteins), white matter injury (MBP), post-injury neurodegeneration (total Tau and phospho-Tau), post-injury autoimmune response (brain antigen-targeting autoantibodies), and other emerging non-protein biomarkers...
January 17, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29338211/highly-stable-rna-capture-by-dense-cationic-polymer-brushes-for-the-design-of-cytocompatible-serum-stable-sirna-delivery-vectors
#19
Danyang Li, Amir S Sharili, John Connelly, Julien E Gautrot
The high density of polymer brushes confers to these coatings unique physico-chemical properties, in particular for the regulation of biomolecular interaction and the design of highly selective coatings for biosensors and protein patterning. Here we show that high density poly(dimethylaminoethyl methacrylate) cationic polymer brushes enable the stable uptake of high levels of oligonucleotides. This is proposed to result from the high degree of crowding and associated increase in entropic driving force for the binding of polyelectrolytes such as nucleic acid molecules...
January 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29334220/computational-design-synthesis-and-structure-property-evaluation-of-1-3-thiazole-based-colour-tunable-multiheterocyclic-small-organic-fluorophores-as-multifunctional-molecular-materials
#20
Rakesh Radhakrishnan, Kumaran G Sreejalekshmi
Probing chemical space of luminescent organic materials built on novel cores is highly imperative for its potential to expand the horizons of advanced functional materials. Small organic fluorophores possessing therapeutic traits can contribute to theranostics. We coupled computational and classical synthetic chemistry strategies for the rational design of 5-(hetero-2-yl)-1,3-thiazoles as colour tunable fluorophore core. With the aid of DFT and TD-DFT, we prove multiheterocyclic system built on thiazole-het core with three inherent tunable sites on thiazole (C2, C4 and C5) capable of accommodating panoply of substituents, as a multifunctional molecular materials' platform...
January 15, 2018: Journal of Organic Chemistry
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