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https://www.readbyqxmd.com/read/28328650/exosomes-in-critical-illness
#1
Nora Terrasini, Vincenzo Lionetti
OBJECTIVE: Exosomes are small, cell-released vesicles (40-100 nm in size) with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells via interstitial fluids. Due to their role in tissue homeostasis, exosomes have emerged as a new type of therapeutic and diagnostic (theranostic) tool in the noninvasive assessment of organ response to injury or treatment and in the development of reliable organ-protective intensive therapy. Our review provides current insights into the role of exosomes in the personalized management of injury and repair responses in critical illness...
March 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28328150/yolk-shell-nanostructure-an-ideal-architecture-to-achieve-harmonious-integration-of-magnetic-plasmonic-hybrid-theranostic-platform
#2
Li-Sen Lin, Xiangyu Yang, Zijian Zhou, Zhen Yang, Orit Jacobson, Yijing Liu, Angela Yang, Gang Niu, Jibin Song, Huang-Hao Yang, Xiaoyuan Chen
Magnetic-plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer theranostics. However, the relaxivity of the magnetic component is typically reduced by the plasmonic component in conventional core-shell structured MPHNs, due to the presence of a water-impenetrable coating which severely restricts the proximity of protons to the magnetic portion. To circumvent this issue, yolk-shell structured MPHNs comprising a Fe3 O4 core within a hollow cavity encircled by a porous Au outer shell are designed...
March 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#3
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#4
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28322153/recent-progress-in-808-nm-excited-upconversion-nanomaterials-as-multifunctional-nanoprobes-for-visualized-theranostics-in-cancers
#5
Leyong Zeng, Di Wu, Ying Tian, Yuanwei Pan, Aiguo Wu, Jinchao Zhang, Guangming Lu
Near-infrared (NIR) light responsive nanomaterials have attracted considerable attention due to their location in the biological window. Especially, lanthanide-doped nanomaterials exhibit unique upconversion luminescence (UCL) properties with low background interference and long luminescence lifetime, which makes them promising in imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating effect and weak penetration depth induced by excitation source...
March 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28322141/lessons-learned-from-gemcitabine-impact-of-therapeutic-carrier-systems-and-gemcitabine-s-drug-conjugates-on-cancer-therapy
#6
Sathish Dyawanapelly, Animesh Kumar, Manish K Chourasia
Currently, drug delivery systems have a high impact in cancer therapy and are receiving more attention than conventional cancer treatment modalities. Compared with current cancer therapies, gemcitabine (2', 2'-difluoro-2'-deoxycytidine) has been proven to be an effective chemotherapeutic agent against pancreatic, colon, bladder, breast, ovarian, non-small-cell lung, and head and neck cancers in combination with other anticancer agents. To improve the safety and efficacy of cytotoxic drugs, several drug delivery systems have been explored...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28322140/applications-and-risks-of-nanomaterials-used-in-regenerative-medicine-delivery-systems-theranostics-and-therapy
#7
Estefany I Medina-Reyes, Danae Garcia-Viacobo, Franklin A Carrero-Martinez, Yolanda Irasema Chirino
Recent advances in nanotechnology have transformed the biomedicine field, in which the use of engineered nanomaterials (ENMs) has provided the foundation for novel applications. For this reason, the number of ENMs has increased rapidly, and here we provide a classification of ENMs based on chemical composition and biomedical applications, which include regenerative medicine, delivery systems, theranostics, and therapy. These have been identified as the most advanced and promising areas for further studies with humans...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28319221/fluorescent-chemical-probes-for-accurate-tumor-diagnosis-and-targeting-therapy
#8
REVIEW
Min Gao, Fabiao Yu, Changjun Lv, Jaebum Choo, Lingxin Chen
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells...
March 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#9
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28304032/facile-synthesis-of-chlorin-bioconjugates-by-a-series-of-click-reactions
#10
Junior Gonzales, N V S Dinesh K Bhupathiraju, William Perea, Huong Chu, Naxhije Berisha, Veronica Bueno, Naser Dodic, Julia Rozenberg, Nancy L Greenbaum, Charles Michael Drain
A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.
March 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28302035/translational-multimodality-neuroimaging
#11
Sushil K Sharma
Recently high-resolution, noninvasive, multimodality in-vivo molecular imaging with PET, SPECT, CT and MRI, employing fusion algorithms has revolutionized personalized medicine. However, specific radiopharmaceuticals (RPs) for the accurate diagnosis and effective treatment of progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, drug addiction, and other cognitive impairments still remain in developmental phase. Currently, multimodality fusion neuroimaging is utilized for the determination of: pharmacokinetics and pre-clinical development of radiopharmaceuticals (RPs); in-vivo monitoring of stem cell transplantation therapy; nicotinic acetylcholine receptors (nAChRs) investigations; and regional cerebral blood flow and glucose metabolism in cognitively-impaired subjects employing noninvasive microPET and nano-SPECT imaging...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28302015/multicolorful-carbon-dots-for-tumor-theranostics
#12
Haitao Wang, Jingran Bi, Beiwei Zhu, Mingqian Tan
Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system...
March 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28301933/ferritin-decorated-plga-paclitaxel-loaded-nanoparticles-endowed-with-an-enhanced-toxicity-towards-mcf-7-breast-tumour-cells
#13
Ludmila N Turino, Maria Ruggiero, Rachele Stefania, Juan Carlos Cutrin, Silvio Aime, Simonetta Geninatti Crich
PolyLactic and Glycolic Acid nanoparticles (PLGA-NPs), coated with L-Ferritin, are exploited for the simultaneous delivery of paclitaxel and an amphiphilic Gd based MRI contrast agent into breast cancer cells (MCF7). L-Ferritin has been covalently conjugated to the external surface of PLGA-NPs exploiting NHS activated carboxylic groups. The results confirmed that nanoparticles decorated with L-Ferritin have many advantages with respect both albumin-decorated and non-decorated particles. Ferritin moieties endow PLGA-NPs with targeting capability, exploiting SCARA5 receptors overexpressed by these tumour cells, that results in an increased paclitaxel cytotoxicity...
March 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28301720/terrylenediimide-based-intrinsic-theranostic-nanomedicines-with-high-photothermal-conversion-efficiency-for-photoacoustic-imaging-guided-cancer-therapy
#14
Shaobo Zhang, Weisheng Guo, Jie Wei, Chan Li, Xing-Jie Liang, Meizhen Yin
Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, terrylenediimide (TDI) was modified with poly(acrylic acid)s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28299923/amphiphilic-semiconducting-oligomer-for-near-infrared-photoacoustic-and-fluorescence-imaging
#15
Chao Yin, Xu Zhen, Hui Zhao, Yufu Tang, Yu Ji, Yan Lyu, Quli Fan, Wei Huang, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have emerged as an alternative class of optical nanoagents for imaging applications. However, the general preparation method for SPNs is nanoprecipitation, which is likely to encounter the issue of nanoparticle dissociation. We herein report non-dissociable near-infrared (NIR)-absorbing organic semiconducting nanoparticles for in vivo photoacoustic (PA) and fluorescence imaging. The nanoparticles are self-assembled from an amphiphilic semiconducting oligomer (ASO) that has a hydrophobic semiconducting oligomer backbone attached by hydrophilic poly(ethylene glycol) (PEG) side chains...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28299722/a-versatile-method-for-the-preparation-of-particle-loaded-microbubbles-for-multimodality-imaging-and-targeted-drug-delivery
#16
Joshua Owen, Calum Crake, Jeong Yu Lee, Dario Carugo, Estelle Beguin, Alexandre A Khrapitchev, Richard J Browning, Nicola Sibson, Eleanor Stride
Microbubbles are currently in clinical use as ultrasound contrast agents and under active investigation as mediators of ultrasound therapy. To improve the theranostic potential of microbubbles, nanoparticles can be attached to the bubble shell for imaging, targeting and/or enhancement of acoustic response. Existing methods for fabricating particle-loaded bubbles, however, require the use of polymers, oil layers or chemical reactions for particle incorporation; embed/attach the particles that can reduce echogenicity; impair biocompatibility; and/or involve multiple processing steps...
March 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28295673/808-nm-light-excited-lanthanide-doped-nanoparticles-rational-design-luminescence-control-and-theranostic-applications
#17
REVIEW
Bei Liu, Chunxia Li, Piaoping Yang, Zhiyao Hou, Jun Lin
808 nm-light-excited lanthanide (Ln(3+) )-doped nanoparticles (LnNPs) hold great promise for a wide range of applications, including bioimaging diagnosis and anticancer therapy. This is due to their unique properties, including their minimized overheating effect, improved penetration depth, relatively high quantum yields, and other common features of LnNPs. In this review, the progress of 808 nm-excited LnNPs is reported, including their i) luminescence mechanism, ii) luminescence enhancement, iii) color tuning, iv) diagnostic and v) therapeutic applications...
March 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28295000/current-status-of-radiopharmaceuticals-for-the-theranostics-of-neuroendocrine-neoplasms
#18
REVIEW
Melpomeni Fani, Petra Kolenc Peitl, Irina Velikyan
Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them...
March 15, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28294582/pioneering-medical-advances-through-nanofluidic-implantable-technologies
#19
REVIEW
R Lyle Hood, Gold Darr Hood, Mauro Ferrari, Alessandro Grattoni
Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point-of-care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present their emergence in medicine within the fields of diagnostics, biosensing, therapeutics, and theranostics. Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible...
March 10, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28294042/green-synthesized-nanomaterials-as-theranostic-platforms-for-cancer-treatment-principles-challenges-and-the-road-ahead
#20
Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai, Gang Liu
With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods...
March 9, 2017: Current Medicinal Chemistry
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