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Daniel L Kenney-Jung, Annamaria Vezzani, Robert J Kahoud, Reghann G LaFrance-Corey, Mai-Lan Ho, Theresa Wampler Muskardin, Elaine C Wirrell, Charles L Howe, Eric T Payne
Febrile infection-related epilepsy syndrome (FIRES) is a devastating epileptic encephalopathy with limited treatment options and an unclear etiology. Anakinra is a recombinant version of the human interleukin-1 receptor antagonist used to treat autoinflammatory disorders. This is the first report of anakinra for treatment of a child with super-refractory status epilepticus secondary to FIRES. Anakinra was well-tolerated and effective. Cerebral spinal fluid analysis revealed elevated levels of proinflammatory cytokines before treatment that normalized on anakinra, suggesting a potential pathogenic role for neuroinflammation in FIRES...
October 22, 2016: Annals of Neurology
Leo H Wang, Michael A Elliott, Lily Jung Henson, Elba Gerena-Maldonado, Susan Strom, Sharon Downing, Jennifer Vetrovs, Paige Kayihan, Piper Paul, Kate Kennedy, Joshua O Benditt, Michael D Weiss
OBJECTIVES: To describe the amyotrophic lateral sclerosis (ALS) patients who sought medication under the Washington State Death with Dignity (DWD) Act since its inception in 2009. METHODS: Chart review at 3 tertiary medical centers in the Seattle/Puget Sound region and comparison to publicly available data of ALS and all-cause DWD cohorts from Washington and Oregon. RESULTS: In Washington State, 39 patients with ALS requested DWD from the University of Washington, Virginia Mason, and Swedish Medical Centers beginning in 2009...
October 21, 2016: Neurology
Su Hui Seong, Anupom Roy, Hyun Ah Jung, Hee Jin Jung, Jae Sue Choi
ETHNOPHARMACOLOGICAL RELEVANCE: Pueraria lobata root was used to treat wasting-thirst regarded as diabetes mellitus and was included in the composition of Okcheonsan, which is prescribed for thirst-waste in traditional Chinese medicine. AIM OF THE STUDY: The objective of this study was to evaluate the anti-diabetic potential of the root of Pueraria lobata and its constituents via protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase inhibitory activities. MATERIALS AND METHODS: In this study, anti-diabetic activities of the 70% ethanolic (EtOH) extract from P...
October 18, 2016: Journal of Ethnopharmacology
Yoon Young Choi, Suji Kim, Jung-Hwa Han, Dae-Hwan Nam, Kwon Moo Park, Seong Yong Kim, Chang-Hoon Woo
Epidemiological studies suggested that diabetic patients are susceptible to develop cardiovascular complications along with having endothelial dysfunction. It has been suggested that methylglyoxal (MGO), a glycolytic metabolite, has more detrimental effects on endothelial dysfunction rather than glucose itself. Here, we investigated the molecular mechanism by which MGO induces endothelial dysfunction via the regulation of ER stress. Biochemical data showed that 4-PBA significantly inhibited MGO-induced protein cleavages of PARP-1 and caspase-3...
October 18, 2016: Biochemical and Biophysical Research Communications
Pei-Jung Lin, Wei-Shi Yeh, Peter J Neumann
OBJECTIVES: The current US mandatory newborn screening panel does not include spinal muscular atrophy, the most common fatal genetic disease among children. We assessed population preferences for newborn screening for spinal muscular atrophy, and how test preferences varied depending on immediate treatment implications. METHODS: We conducted an online willingness-to-pay survey of US adults (n = 982). Respondents were asked to imagine being parents of a newborn...
September 15, 2016: Pediatric Neurology
Soyoung Kim, Jonggul Lee, Eunok Jung
A mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention...
October 18, 2016: Journal of Theoretical Biology
Byung Sup Kim, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee
Residual or recurrent hemangiopericytoma (HPC) has been treated with radiosurgery; however, its long-term outcome is not well known. This study is to investigate the long-term outcome of gamma knife radiosurgery (GKS) for residual or recurrent HPCs. We conducted a retrospective analysis of 18 patients who underwent gamma knife radiosurgery for residual or recurrent HPCs. Of the 18 patients, 10 patients had high-grade HPCs (27 tumors) and 8 had low-grade HPCs (13 tumors). Median overall survival (OS) after the first GKS was 134...
October 18, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Seong Hee Kang, Keunhee Kang, Jong Eun Yeon, Young Sun Lee, Tae Suk Kim, Yang Jae Yoo, Sang Jun Suh, Eileen L Yoon, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Kwan Soo Byun
BACKGROUND & AIM: Although the ideal end point for antiviral treatment in patients with chronic hepatitis B (CHB) is loss of HBsAg, the typical clinical end points are HBeAg seroconversion in HBeAg-positive patients and long-term DNA suppression in HBeAg-negative patients. We evaluated the long-term antiviral response after cessation of lamivudine treatment in CHB patients. METHODS: A total of 157 patients who had discontinued lamivudine between 1997 and 2014 were enrolled (97 HBeAg-positive and 60 HBeAg-negative CHB patients)...
October 21, 2016: Journal of Medical Virology
Martin Heberle, Stefanie Tschierlei, Nils Rockstroh, Mark Ringenberg, Wolfgang Frey, Henrik Junge, Matthias Beller, Stefan Lochbrunner, Michael Karnahl
A series of heteroleptic copper(I) photosensitizers of the type [(P^P)Cu(N^N)]+ with an extended π-system in the backbone of the diimine ligand have been prepared. The structures of all complexes are completely characterized by NMR spectroscopy, mass spectrometry and X-ray crystallography. These novel photosensitizers were assessed with respect to the photocatalytic reduction of protons in the presence of triethylamine and [Fe3(CO)12]. While the solid state structures and computational results show no significant impact of the π-extension on the structural properties decreased activities were observed...
October 21, 2016: Chemistry: a European Journal
Hok Sum Sam Lai, Feifei Wang, Yi Li, Boliang Jia, Lianqing Liu, Wen Jung Li
Microsphere-assisted microscopy has received a lot of attention recently due to its simplicity and its capability to surpass the diffraction limit. However, to date, sub-diffraction-limit features have only been observed in virtual images formed through the microspheres. We show that it is possible to form real, super-resolution images using high-refractive index microspheres. Also, we report on how changes to a microsphere's refractive index and size affect image formation and planes. The relationship between the focus position and the additional magnification factor is also investigated using experimental and theoretical methods...
2016: PloS One
Hwi Young Jang, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Dong Myung Yeo, Sung Eun Rha, Eun Sun Jung, Young Kyoung You, Dong Goo Kim, Jae Young Byun
PURPOSE: This study aimed to evaluate the accuracy of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in predicting eligibility for liver transplantation in patients with hepatocellular carcinoma (HCC) based on Milan criteria (MC). MATERIALS AND METHODS: We reviewed Gd-EOB-MRI of 44 patients who underwent liver transplantation for HCC with cirrhosis for the presence/size of HCCs, vascular invasion, and transplant eligibility based on MC. Hepatocellular carcinoma was diagnosed based on conventional radiological hallmarks (arterial enhancement and washout) or the modified criteria...
October 20, 2016: Journal of Computer Assisted Tomography
Kayoung Kim, Sung-Hwan Choi, Eun-Hee Choi, Yoon-Jeong Choi, Chung-Ju Hwang, Jung-Yul Cha
OBJECTIVE: To compare soft and hard tissue responses based on the degree of maxillary incisor retraction using maximum anchorage in patients with Class II Division 1 malocclusion. MATERIALS AND METHODS: This retrospective study sample was divided into moderate retraction (<8.0 mm; n = 28) and maximum retraction (≥8.0 mm; n = 29) groups based on the amount of maxillary incisor retraction after extraction of the maxillary and mandibular first premolars for camouflage treatment...
September 19, 2016: Angle Orthodontist
H Abdalla, A Abramowski, F Aharonian, F Ait Benkhali, A G Akhperjanian, T Andersson, E O Angüner, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, E Birsin, R Blackwell, M Böttcher, C Boisson, J Bolmont, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, T Bulik, M Capasso, J Carr, S Casanova, N Chakraborty, R Chalme-Calvet, R C G Chaves, A Chen, J Chevalier, M Chrétien, S Colafrancesco, G Cologna, B Condon, J Conrad, C Couturier, Y Cui, I D Davids, B Degrange, C Deil, J Devin, P deWilt, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, G Dubus, K Dutson, J Dyks, M Dyrda, T Edwards, K Egberts, P Eger, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, M Gajdus, Y A Gallant, T Garrigoux, G Giavitto, B Giebels, J F Glicenstein, D Gottschall, A Goyal, M-H Grondin, M Grudzińska, D Hadasch, J Hahn, J Hawkes, G Heinzelmann, G Henri, G Hermann, O Hervet, A Hillert, J A Hinton, W Hofmann, C Hoischen, M Holler, D Horns, A Ivascenko, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, T Jogler, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, U Katz, D Kerszberg, B Khélifi, M Kieffer, J King, S Klepser, D Klochkov, W Kluźniak, D Kolitzus, Nu Komin, K Kosack, S Krakau, M Kraus, F Krayzel, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, V Lefranc, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, I Lypova, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, K Morå, E Moulin, T Murach, M de Naurois, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, S Öttl, I Oya, M Padovani, M Panter, R D Parsons, M Paz Arribas, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, S Pita, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, C Romoli, S Rosier-Lees, G Rowell, B Rudak, C B Rulten, V Sahakian, D Salek, D A Sanchez, A Santangelo, M Sasaki, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Settimo, A S Seyffert, N Shafi, I Shilon, R Simoni, H Sol, F Spanier, G Spengler, F Spies, Ł Stawarz, R Steenkamp, C Stegmann, F Stinzing, K Stycz, I Sushch, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, M Tluczykont, C Trichard, R Tuffs, J van der Walt, C van Eldik, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, V Zabalza, D Zaborov, M Zacharias, A A Zdziarski, A Zech, F Zefi, A Ziegler, N Żywucka
: A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1...
October 7, 2016: Physical Review Letters
Hung-Wei Yang, Rung-Ywan Tsai, Jung-Po Chen, Shin-Pon Ju, Jing-Fong Liao, KuoChen Wei, Wei-Lun Zou, Mu-Yi Hua
A simple and accurate device for early detection of malignancies is paramount for prompt treatment and prevention of metastases. In this study, we describe a novel fabrication method for producing an ordered nano-gold-dot array with strong localized surface plasmon resonance (LSPR) and narrow bandwidth. The array was used as an optical bio-sensing chip for the detection of vascular endothelial growth factor (VEGF) in human serum. The biochip was constructed by conjugating an anti-VEGF antibody, a specific bio-recognition element for VEGF, onto the array via the fragment crystallizable (Fc) region of the antibody, ultimately increasing the efficiency of VEGF detection...
October 21, 2016: ACS Applied Materials & Interfaces
N Platz Batista da Silva, M Schauer, M Hornung, S Lang, L P Beyer, I Wiesinger, C Stroszczynski, E M Jung
OBJECTIVE: To evaluate the efficacy of strain elastography (SE) using semi-quantitative measurement methods compared to constrast enhanced ultrasound during liver tumor surgery (Io-CEUS) for dignity assessment of focal liver lesions(FLL). MATERIAL AND METHODS: Prospective data acquisition and retrospective analysis of US data of 100 patients (116 lesions) who underwent liver tumor surgery between 10/2010 and 03/2016. Retrospective reading of SE color patterns was performed establishing groups depending on dominant color (>50% blue = stiff, inhomogenous, >50% yellow/red/green = soft tissue)...
October 20, 2016: Clinical Hemorheology and Microcirculation
Christian Schulz, Radovan Vukićević, Anne Krüger-Genge, Axel T Neffe, Andreas Lendlein, Friedrich Jung
The formation of a functionally-confluent and shear-resistant endothelial cell monolayer on cardiovascular implants is a promising strategy to prevent thrombogenic processes after implantation. On the basis of existing studies with arterial endothelial cells adhering after two hours on gelatin-based hydrogels in marked higher numbers compared to tissue culture plates, we hypothesize that also venous endothelial cells (HUVEC) should be able to adhere and form an endothelial monolayer on these hydrogels after days...
October 15, 2016: Clinical Hemorheology and Microcirculation
Jong Hwan Jung, Yoon Jung Chae, Dong Hwan Lee, Young I Cho, Mi Mi Ko, Sung Kwang Park, Won Kim
Whole blood viscosity (WBV) plays a role in hemorheology and is determined by many factors such as red blood cell factors, plasma protein and blood volume. As WBV changes during hemodialysis, mortality may be due to changes in WBV in patients on hemodialysis. However, there are few prospective data on the relationship between changes in WBV and overall mortality in dialysis patients. We tried to investigate the correlations between values of WBV at variable shear rates before and after hemodialysis and overall or atherosclerosis-related mortality in patients with end-stage kidney disease...
October 20, 2016: Clinical Hemorheology and Microcirculation
Jong Ho Park, Jung Jin Park, O Ok Park, Jung Hoon Yang
Capacity decay in vanadium redox flow batteries during charge-discharge cycling has become an important issue because it lowers the practical energy density of the battery. The battery capacity tends to drop rapidly within the first tens of cycles and then drops more gradually over subsequent cycles during long-term operation. This paper analyzes and discusses the reasons for this early capacity decay. The imbalanced crossover rate of vanadium species was found to remain high until the total difference in vanadium concentration between the positive and negative electrolytes reached almost 1 mol dm(-3) ...
October 21, 2016: ChemSusChem
Shin Yup Lee, Cheng Cheng Jin, Jin Eun Choi, Mi Jeong Hong, Deuk Kju Jung, Sook Kyung Do, Sun Ah Baek, Hyo Jung Kang, Hyo-Gyoung Kang, Sun Ha Choi, Won Kee Lee, Yangki Seok, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin, Sukki Cho, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, You Mie Lee, In-Kyu Lee, Sanghoon Jheon, Jae Yong Park
This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses...
October 21, 2016: Scientific Reports
Eui Jin Lee, Jae Pil Han, Seung Eun Jung, Min Hee Choi, Doo Kyung Moon
In this study, we fabricated conventional structured organic solar cells (OSCs) by introducing a hole extraction layer (HEL) that consisted of poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) and conjugated polymer electrolyte (CPE) poly[9,9-bis(4'-sulfonatobutyl)fluorene-alt-thiophene] (PFT-D). PFT-D has a -SO3(-) functional group that acts as a conjugate base against the -SO3H of PSS. In addition, the molecular dipole of PFT-D can screen the coulombic attraction between PEDOT chains and PSS chains...
October 21, 2016: ACS Applied Materials & Interfaces
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