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https://www.readbyqxmd.com/read/27933080/identification-of-a-dolabellane-type-diterpene-synthase-and-other-root-expressed-diterpene-synthases-in-arabidopsis
#1
Qiang Wang, Meirong Jia, Jung-Hyun Huh, Andrew Muchlinski, Reuben J Peters, Dorothea Tholl
Arabidopsis thaliana maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which have been associated with direct and indirect defensive activities in flowers and leaves. In comparison, the structural diversity and function of terpenes in Arabidopsis roots has remained largely unexplored despite a substantial number of root-expressed genes in the Arabidopsis terpene synthase (TPS) gene family. We show that five root-expressed TPSs of an expanded subfamily-a type clade in the Arabidopsis TPS family function as class I diterpene synthases that predominantly convert geranylgeranyl diphosphate (GGPP) to different semi-volatile diterpene products, which are in part detectable at low levels in the ecotypes Columbia (Col) and Cape Verde Island (Cvi)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27932512/atf6-decreases-myocardial-ischemia-reperfusion-damage-and-links-er-stress-and-oxidative-stress-signaling-pathways-in-the-heart
#2
Jung-Kang Jin, Erik A Blackwood, Khalid M Azizi, Donna J Thuerauf, Asal G Fahem, Christoph Hofmann, Randal J Kaufman, Shirin Doroudgar, Christopher C Glembotski
RATIONALE: ER stress causes accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6, which induces ER stress response genes. Myocardial ischemia induces the ER stress response; however, neither the function of this response nor whether it is mediated by ATF6 is known. OBJECTIVE: Here, we examined the effects of blocking the ATF6-mediated ER stress response on ischemia/reperfusion (I/R) in cardiac myocytes and mouse hearts. METHODS AND RESULTS: Knockdown of ATF6 in cardiac myocytes subjected to I/R increased ROS and necrotic cell death, which were mitigated by ATF6 overexpression...
December 8, 2016: Circulation Research
https://www.readbyqxmd.com/read/27932495/modulations-of-sir-nucleosome-interactions-of-reconstructed-yeast-silent-pre-heterochromatin-by-o-acetyl-adp-ribose-and-magnesium
#3
Shu-Yun Tung, Sue-Hong Wang, Sue-Ping Lee, Shu-Ping Tsai, Hsiao-Hsuian Shen, Feng-Jung Chen, Yu-Yi Wu, Sheng-Pin Hsiao, Gunn-Guang Liou
To study epigenetic inheritance, yeast silent heterochromatin provides an excellent model. Previously, we developed an in vitro assembly system to demonstrate the formation of filament structures with requirements that mirror yeast epigenetic gene silencing in vivo However, the properties of these filaments have not been investigated in detail. Here, we show that the assembly system requires Sir2, Sir3, Sir4, nucleosomes and O-acetyl-ADP-ribose. We also demonstrate that all Sir proteins and nucleosomes are components of these filaments to prove they are SIR-nucleosome filaments...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27932427/retrieval-of-the-leadless-cardiac-pacemaker-a-multicenter-experience
#4
Vivek Y Reddy, Marc A Miller, Reinoud E Knops, Petr Neuzil, Pascal Defaye, Werner Jung, Rahul Doshi, Mark Castellani, Adam Strickberger, R Hardwin Mead, Harish Doppalapudi, Dhanunjaya Lakkireddy, Matthew Bennett, Johannes Sperzel
BACKGROUND: Leadless cardiac pacemakers have emerged as a safe and effective alternative to conventional transvenous single-chamber ventricular pacemakers. Herein, we report a multicenter experience on the feasibility and safety of acute retrieval (<6 weeks) and chronic retrieval (>6 weeks) of the leadless cardiac pacemaker in humans. METHODS AND RESULTS: This study included patients enrolled in 3 multicenter trials, who received a leadless cardiac pacemaker implant and who subsequently underwent a device removal attempt...
December 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27932363/monocyte-count-as-a-predictor-of-cardiovascular-mortality-in-older-korean-people
#5
Sung Hee Choi, Jung Hee Kim, Soo Lim, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang
BACKGROUND: white blood cells (WBCs) have been known to mediate the inflammatory process, which may be a pivotal mechanism for atherosclerosis and cardiovascular mortality. OBJECTIVE: we investigated which WBC subtypes increased cardiovascular mortality and explored its connection to coronary artery diseases in a prospective study among older Koreans. STUDY DESIGN AND SUBJECTS: this study was conducted from 2005 to 2011 as a part of the Korean Longitudinal Study on Health and Aging and included 439 men and 561 women over 65-year old...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932314/tis21-btg2-inhibits-doxorubicin-induced-stress-fiber-vimentin-networks-via-nox4-ros-abi2-drf-linked-signal-cascade
#6
In Kyoung Lim, Jung-A Choi, Eun Young Kim, Bit Na Kim, Soohyun Jang, Min Sook Ryu, Sang-Hee Shim
Activities of TIS21(/BTG2) gene regulating cancer cell senescence were investigated in hepatoma cells by using low dose doxorubicin (Doxo, 100ng/mL). Treatment of Huh7 cells with Doxo increased linear actin nucleation e.g., transverse arcs and ventral stress fibers, as opposed to loss of filopodia. The linear actin nucleation was accompanied with thick vimentin networks at periphery of the cells, when examined by super-resolution STED microscope. However, expression of TIS21 inhibited ABI2-DRF pathway by inhibiting DRF expression and reducing ABI2 protein stability...
December 5, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27932031/number-of-rib-fractures-thresholds-independently-predict-worse-outcomes-in-older-patients-with-blunt-trauma
#7
Nikita O Shulzhenko, Tiffany J Zens, Megan V Beems, Hee Soo Jung, Ann P O'Rourke, Amy E Liepert, John E Scarborough, Suresh K Agarwal
BACKGROUND: There have been conflicting reports regarding whether the number of rib fractures sustained in blunt trauma is associated independently with worse patient outcomes. We sought to investigate this risk-adjusted relationship among the lesser-studied population of older adults. METHODS: A retrospective review of the National Trauma Data Bank was performed for patients with blunt trauma who were ≥65 years old and had rib fractures between 2009 and 2012 (N = 67,695)...
December 5, 2016: Surgery
https://www.readbyqxmd.com/read/27932020/night-eating-syndrome-and-the-severity-of-self-reported-depressive-symptoms-from-the-korea-nurses-health-study-analysis-of-propensity-score-matching-and-ordinal-regression
#8
O-S Kim, M S Kim, J E Lee, H Jung
OBJECTIVES: The prevalence of night-eating syndrome (NES) and depression is increasing worldwide. Although nurses, in particular, are exposed to work in an environment of irregular eating, shift work, and stressful settings, limited research exist. In fact, the prevalence of NES among Korean nurses has never been reported. The aim of this study was to determine the prevalence of NES as well as the association between NES and severity of self-reported depressive symptoms among South Korean female nurses...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931881/pm2-5-source-attribution-for-seoul-in-may-from-2009-to-2013-using-geos-chem-and-its-adjoint-model
#9
Hyung-Min Lee, Rokjin J Park, Daven K Henze, Seungun Lee, Changsub Shim, Hye-Jung Shin, Kwang-Joo Moon, Jung-Hun Woo
Enforcement of an air quality standard for PM2.5 in the Seoul metropolitan area (SMA) was enacted in 2015. From May to June of 2016, an international airborne and surface measurement campaign took place to investigate air pollution mechanisms in the SMA. The total and speciated PM2.5 concentrations since 2008 have been measured at an intensive monitoring site for the SMA operated by the National Institute of Environmental Research (NIER). To gain insight on the trends and sources of PM2.5 in the SMA in May, we analyze PM2...
December 5, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27931719/a-potential-pitfall-in-evaluating-her2-immunohistochemistry-for-gastric-signet-ring-cell-carcinomas
#10
Chang Gok Woo, Won Jin Ho, Young Soo Park, Sook Ryun Park, Min-Hee Ryu, Hwoon-Yong Jung, Yoon-Koo Kang
Signet ring cell carcinoma (SRC) more commonly presents as metastatic disease and renders patients to be considered for chemotherapy. While treatment options are limited overall, trastuzumab has been shown to be effective for HER2 positive SRC cases. The current algorithm for HER2 evaluation heavily relies on positive membrane-specific staining by immunohistochemistry (IHC), but several anecdotal reports have suggested that SRCs may be susceptible to misinterpretation due to non-specific staining in the marginated cytoplasm with/without nucleus...
December 5, 2016: Pathology
https://www.readbyqxmd.com/read/27931714/host-plant-growth-promotion-and-cadmium-detoxification-in-solanum-nigrum-mediated-by-endophytic-fungi
#11
Abdur Rahim Khan, Ihsan Ullah, Muhammad Waqas, Gun-Seok Park, Abdul Latif Khan, Sung-Jun Hong, Rehman Ullah, Byung Kwon Jung, Chang Eon Park, Shafiq Ur-Rehman, In-Jung Lee, Jae-Ho Shin
Current investigation conducted to evaluate the associated fungal endophyte interactions of a Cd hyper-accumulator Solanum nigrum Korean ecotype under varying concentrations of Cd. Two indole-3-acetic acid (IAA) producing fungal strains, RSF-4L and RSF-6L, isolated from the leaves of S. nigrum, were initially screened for Cd tolerance and accumulation potential. In terms of dry biomass production, the strain RSF-6L showed higher tolerance and accumulation capacity for Cd toxicity in comparison to RSF-4L. Therefore, RSF-6L was applied in vivo to S...
February 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27931583/acute-graft-vs-host-disease-after-liver-transplantation-experience-at-a-high-volume-liver-transplantation-center-in-korea
#12
W H Kang, S Hwang, G W Song, D H Jung, G C Park, C S Ahn, D B Moon, K H Kim, T Y Ha, W J Kim, S H Kim, H D Cho, J H Kwon, E K Jwa, S G Lee
BACKGROUND: Acute graft-vs-host disease (GVHD) is a rare but life-threatening complication of orthotopic liver transplantation (OLT). We present 6 cases of GVHD after OLT. METHODS: Among our 4294 OLT recipients, we identified 6 patients (0.14%) who were diagnosed with GVHD. Their medical records were reviewed retrospectively. RESULTS: Liver graft types included deceased donor whole liver graft (n = 3) and right liver graft from son (n = 3)...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931264/centrifugal-gravity-induced-bmp4-induces-chondrogenic-differentiation-of-adipose-derived-stem-cells-via-sox9-upregulation
#13
Yeonsue Jang, Hyerin Jung, Yoojun Nam, Yeri Alice Rim, Juryun Kim, Sang Hoon Jeong, Ji Hyeon Ju
BACKGROUND: Cartilage does not have the capability to regenerate itself. Therefore, stem cell transplantation is a promising therapeutic approach for impaired cartilage. For stem cell transplantation, in vitro enrichment is required; however, stem cells not only become senescent but also lose their differentiation potency during this process. In addition, cytokines are normally used for chondrogenic differentiation induction of stem cells, which is highly expensive and needs an additional step to culture...
December 8, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27931244/association-of-lower-extremity-range-of-motion-and-muscle-strength-with-physical-performance-of-community-dwelling-older-women
#14
Hungu Jung, Masahiro Yamasaki
BACKGROUND: Reduced lower extremity range of motion (ROM) and muscle strength are related to functional disability in older adults who cannot perform one or more activities of daily living (ADL) independently. The purpose of this study was to determine which factors of seven lower extremity ROMs and two muscle strengths play dominant roles in the physical performance of community-dwelling older women. METHODS: Ninety-five community-dwelling older women (mean age ± SD, 70...
December 8, 2016: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/27930863/lessons-from-a-cardiovascular-outcome-trial-with-liraglutide-in-type-2-diabetes
#15
Hae Jin Kim, Dae Jung Kim
Cardiovascular disease (CVD) is the leading cause of death and one of common diabetes-related complications in patients with type 2 diabetes(1) . After the US Food and Drug Administration issued guidelines for assessing the CVD risk of all new glucose-lowering agents for type 2 diabetes in 2008(2) , randomized controlled CV outcome trials with new antidiabetic drugs, such as the dipeptidyl peptidase-4 inhibitors (saxagliptin, alogliptin, and sitagliptin) and the glucagon-like peptide-1 receptor agonist (GLP-1 RA), lixisenatide, showed CV safety in high CV risk patient populations with type 2 diabtes(3) ...
December 8, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27930845/isolation-and-characterization-of-rna-aptamers-against-a-proteasome-associated-deubiquitylating-enzyme-uch37
#16
Jung Hoon Lee, Min Jae Lee
Deubiquitylating (DUB) enzymes antagonize ubiquitin-dependent protein degradation both before and after the substrates are engaged with proteasomes. UCH37 is one of three proteasome-associated DUB enzymes in mammals and the only protease among them from the ubiquitin carboxyl-terminal hydrolase (UCH) family. Here, we report the identification of specific RNA aptamers for UCH37 through in vitro selection, and we describe their inhibitory effects on the DUB activity of UCH37. The RNA aptamers significantly delayed RPN13-mediated UCH37 activation and lowered total DUB activity of proteasomes, as measured by the hydrolysis of ubiquitin-rhodamine 110...
December 8, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27930717/a-patient-specific-polylactic-acid-bolus-made-by-a-3d-printer-for-breast-cancer-radiation-therapy
#17
So-Yeon Park, Chang Heon Choi, Jong Min Park, MinSoo Chun, Ji Hye Han, Jung-In Kim
PURPOSE: The aim of this study was to assess the feasibility and advantages of a patient-specific breast bolus made using a 3D printer technique. METHODS: We used the anthropomorphic female phantom with breast attachments, which volumes are 200, 300, 400, 500 and 650 cc. We simulated the treatment for a right breast patient using parallel opposed tangential fields. Treatment plans were used to investigate the effect of unwanted air gaps under bolus on the dose distribution of the whole breast...
2016: PloS One
https://www.readbyqxmd.com/read/27930581/associations-between-interventions-for-urolithiasis-and-urinary-tract-cancer-among-patients-in-taiwan-the-effect-of-early-intervention
#18
Chien-Liang Lin, Wen-Tsung Huang, Wen-Chou Fan, Yin-Hsun Feng, Chia-Ho Lin, Chian-Shiung Lin, Chih-Cheng Lu, Tse-Chou Cheng, Chao-Jung Tsao, Sheng-Hsiang Lin
The aim of this study was to investigate cancer risk in patients with a history of urolithiasis and to determine whether intervention for calculi attenuated the risk of subsequent urinary tract cancer (UTC).Using data from the National Health Insurance Research Database in Taiwan, we performed a nationwide cohort study enrolling participants (n = 42,732) aged > 30 years who were diagnosed with urinary tract calculi between 2000 and 2009. Age- and gender-matched insured individuals (n = 213,660) found in the health service records over the same period were recruited as the control group...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930534/does-the-interval-of-screening-endoscopy-affect-survival-in-gastric-cancer-patients-a-cross-sectional-study
#19
Jieun Kim, Su Mi Kim, Man Ho Ha, Jeong Eun Seo, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Sin-Ho Jung, Jae Moon Bae
Gastric cancer remains the second most common cancer in Korea; however, its mortality has decreased due to earlier diagnosis. In Korea, screening endoscopy has been performed nationwide since 1999. The aim of this study was to elucidate the benefit of screening endoscopy on actual survival in gastric cancer patients and to determine the optimal interval of screening endoscopy.We analyzed 1651 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment between June 2008 and December 2014...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930531/prospective-randomized-and-controlled-trial-on-ketamine-infusion-during-bilateral-axillo-breast-approach-baba-robotic-or-endoscopic-thyroidectomy-effects-on-postoperative-pain-and-recovery-profiles-a-consort-compliant-article
#20
Dong-Ho Kim, June Young Choi, Byoung-Gook Kim, Jin-Young Hwang, Seong-Joo Park, Ah-Young Oh, Young-Tae Jeon, Jung-Hee Ryu
BACKGROUND: Robotic or endoscopic thyroidectomy using bilateral axillo-breast approach (BABA) is frequently performed for excellent cosmesis. However, postoperative pain is remained as concerns due to the extent tissue dissection and tension during the operation. Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that reduces acute postoperative pain. We evaluated the effects of intraoperative ketamine infusion on postoperative pain control and recovery profiles following BABA robotic or endoscopic thyroidectomy...
December 2016: Medicine (Baltimore)
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