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https://www.readbyqxmd.com/read/29222900/comparisons-of-proteomic-profiles-of-whey-protein-between-donor-human-milk-collected-earlier-than-3-months-and-6-months-after-delivery
#1
Won-Ho Hahn, Joon-Hwan Song, Jong-Bok Seo, Jung Eun Lee, Jeong-Sang Lee, Seunghyun Song, Joohyun Lee, Nam Mi Kang
BACKGROUND AND OBJECTIVES: Human milk has nutritional, protective, and developmental advantages for premature infants. However, proteomic information of low abundant protein of donor milk is insufficient. The purpose of this study is to analyze and compare the proteome of low abundant protein of donor milk obtained at different postpartum ages other than the colostrum. METHODS AND STUDY DESIGN: Donor breast milk from 12 healthy mothers was collected 15 days, 2 months and 6 months after delivery and stored by medically approved methods...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222530/seizure-rates-in-enzalutamide-treated-men-with-metastatic-castration-resistant-prostate-cancer-and-risk-of-seizure-the-upward-study
#2
Susan Slovin, William Clark, Joan Carles, Andrew Krivoshik, Jung Wook Park, Fong Wang, Daniel George
Importance: The androgen receptor inhibitor enzalutamide prolongs survival in men with metastatic castration-resistant prostate cancer (mCRPC). In controlled clinical studies, 0.5% (10 of 2051) of patients experienced seizure, but patients with a history of or risk factors for seizure were excluded. Men with mCRPC and seizure risk factors have an estimated seizure rate of 2.8 per 100 patient-years without enzalutamide exposure. Objective: To assess seizure incidence in patients with seizure risk factors who were receiving enzalutamide for mCRPC...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222479/gdf15-deficiency-exacerbates-chronic-alcohol-and-carbon-tetrachloride-induced-liver-injury
#3
Hyo Kyun Chung, Jung Tae Kim, Hyeon-Woo Kim, Minjoo Kwon, So Yeon Kim, Minho Shong, Koon Soon Kim, Hyon-Seung Yi
Growth differentiation factor 15 (GDF15) has recently been shown to have an important role in the regulation of mitochondrial function and in the pathogenesis of complex human diseases. Nevertheless, the role of GDF15 in alcohol-induced or fibrotic liver diseases has yet to be determined. In this study, we demonstrate that alcohol- or carbon tetrachloride (CCl4)-mediated hepatic GDF15 production ameliorates liver inflammation and fibrosis. Alcohol directly enhanced GDF15 expression in primary hepatocytes, which led to increased oxygen consumption...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222450/elevation-of-autophagy-markers-in-sj%C3%A3-gren-syndrome-dry-eye
#4
Yong-Soo Byun, Hyun Jung Lee, Soojung Shin, So-Hyang Chung
Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhibited lower Schirmer values, lower tear breakup time, and higher ocular staining scores. In tears, ATG5 and LC3B-II/I levels were significantly higher in SS dry eye. ATG5 and LC3B-II mRNA in the conjunctiva were also elevated in SS dry eye compared with non-SS dry eye...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222330/discovery-of-stimulator-binding-to-a-conserved-pocket-in-the-heme-domain-of-soluble-guanylyl-cyclase
#5
Jessica A Wales, Cheng-Yu Chen, Linda Breci, Andrzej Weichsel, Sylvie G Bernier, James E Sheppeck, Robert Solinga, Takashi Nakai, Paul A Renhowe, Joon Jung, William R Montfort
Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New compounds that stimulate sGC show clinical promise, but where these stimulator compounds bind and how they function remains unknown. Here, using a photolyzable diazirine derivative of a novel stimulator compound, IWP-051, and MS analysis, we localized drug binding to the β1 heme domain of sGC proteins from the hawkmoth Manduca sexta and from human. Covalent attachments to the stimulator were also identified in bacterial homologs of the sGC heme domain, referred to as H-NOX domains, including those from Nostoc sp...
December 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29221856/light-triggered-dissociation-of-self-assembled-%C3%AE-amyloid-aggregates-into-small-nontoxic-fragments-by-ruthenium-ii-complex
#6
Giyeong Son, Byung Il Lee, You Jung Chung, Chan Beum Park
The self-assembly of β-amyloid (A β) peptides into highly stable plaques is a major hallmark of Alzheimer's disease. Here, we report visible light-driven dissociation of β -sheet-rich A β aggregates into small, nontoxic fragments using ruthenium (II) complex {[Ru(bpy)3]2+} that functions as a highly sensitive, biocompatible, photoresponsive anti-A β agent. According to our multiple analyses using thioflavin T, bicinchoninic acid, dynamic light scattering, atomic force microscopy, circular dichroism, and Fourier transform infrared spectroscopy, [Ru(bpy)3]2+ successfully disassembled A β aggregates by destabilizing the β -sheet secondary structure under illumination of white light-emitting diode light...
December 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29221748/hydroxyethyl-starch-is-associated-with-early-postoperative-delirium-in-patients-undergoing-esophagectomy
#7
Dae Myung Jung, Hyun Joo Ahn, Mikyung Yang, Jie Ae Kim, Duck Kyung Kim, Sangmin Maria Lee, Joo Hyun Park
OBJECTIVE: Postoperative delirium is associated with longer hospital stay and increased morbidities. Patients undergoing esophagectomy have a high chance of developing postoperative delirium because of their advanced age, comorbidities, and intensive care unit care. In this study, we investigated the risk factors of early postoperative delirium in patients undergoing esophagectomy, focusing on perioperative fluid type to test the hypothesis that colloids with high oncotic pressure and anti-inflammatory action would decrease the incidence of postoperative delirium compared with crystalloids...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221526/children-s-environmental-health-indicators-for-low-and-middle-income-countries-in-asia
#8
Eun Mi Jung, Eun Mee Kim, Minah Kang, Fiona Goldizen, Fiona Gore, Marie Noel Brune Drisse, Eun Hee Ha
BACKGROUND: Given that low- and middle-income countries (LMICs) in Asia still have high child mortality rates, improved monitoring using children's environmental health indicators (CEHI) may help reduce preventable deaths by creating healthy environments. OBJECTIVES: Thus, the aim of this study is to build a set of targeted CEHI that can be applied in LMICs in Asia through the CEHI initiative using a common conceptual framework. METHODS: A systematic review was conducted to identify the most frequently used framework for developing CEHI...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29221503/editorial
#9
EDITORIAL
Jung Soo Suk, Junghae Suh, Honggang Cui, Anthony J Kim, Seulki Lee, Yoon Yeo
No abstract text is available yet for this article.
December 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29221340/sudden-hypotension-occurring-after-4-days-of-left-sided-central-catheter-placement
#10
Youn-Jung Kim, Won Young Kim
Central venous catheters (CVCs) have an important role in the management of critically ill patients. In contrast to the immediate complications after CVC insertion, the late complications were difficult to be noticed without high suspicion despite their life-threatening outcome. We report a rare but fatal delayed vascular perforation occurring after 4 days of left-sided hemodialysis catheter insertion. A 74-year-old male with septic shock was treated with continuous renal replacement therapy (CRRT) and recovered smoothly during hospitalization...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221108/checkpoint-and-parp-inhibitors-for-whom-and-when
#11
EDITORIAL
Jung-Min Lee, James L Gulley
No abstract text is available yet for this article.
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221001/two-dimensional-grating-guided-mode-resonance-tunable-filter
#12
Wen-Kai Kuo, Che-Jung Hsu
A two-dimensional (2D) grating guided-mode resonance (GMR) tunable filter is experimentally demonstrated using a low-cost two-step nanoimprinting technology with a one-dimensional (1D) grating polydimethylsiloxane mold. For the first nanoimprinting, we precisely control the UV LED irradiation dosage and demold the device when the UV glue is partially cured and the 1D grating mold is then rotated by three different angles, 30°, 60°, and 90°, for the second nanoimprinting to obtain 2D grating structures with different crossing angles...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220877/increased-circulating-plasma-cells-detected-by-flow-cytometry-predicts-poor-prognosis-in-patients-with-plasma-cell-myeloma
#13
Mi Hyun Bae, Chan-Jeoung Park, Bo Hyun Kim, Young-Uk Cho, Seongsoo Jang, Dong-Hyun Lee, Eul-Ju Seo, Dok Hyun Yoon, Jung-Hee Lee, Cheolwon Suh
BACKGROUND: Flow cytometry (FC) is a reliable tool for diagnosing and monitoring of plasma cell myeloma (PCM). Recent studies used FC for quantifying plasma cells (PCs) in peripheral blood (PB) using various panels, and an adverse prognostic effect of circulating PCs (cPCs) has been reported. We investigated the prognostic implication of cPCs quantified using a simple panel in patients with PCM. METHODS: Bone marrow (BM) and PB of 85 patients with PCM were analyzed by five-color FC at time of diagnosis...
December 8, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29220426/isl1%C3%AE-over-expression-with-key-%C3%AE-cell-transcription-factors-enhances-glucose-responsive-hepatic-insulin-production-and-secretion
#14
Yunshin Jung, Ruyi Zhou, Toshiki Kato, Jeffrey K Usui, Masafumi Muratani, Hisashi Oishi, Margarete M S Heck, Satoru Takahashi
Adenoviral gene transfer of key β cell developmental regulators including Pdx1, Neurod1 and Mafa (PDA) has been reported to generate insulin-producing cells in liver. However, PDA insulin secretion is transient and glucose unresponsive. Here, we report that an additional β cell developmental regulator, insulin gene enhancer binding protein splicing variant (Isl1β), improved insulin production and glucose-responsive secretion in PDA mouse. Microarray gene expression analysis suggested that adenoviral PDA transfer required an additional element for mature β cell generation, such as Isl1 and Elf3 in liver...
December 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/29220317/no-reference-image-quality-assessment-by-wide-perceptual-domain-scorer-ensemble-method
#15
Tsung-Jung Liu, Kuan-Hsien Liu
A no-reference (NR) learning-based approach to assess image quality is presented in this paper. The devised features are extracted from wide perceptual domains, including brightness, contrast, color, distortion, and texture. These features are used to train a model (scorer) which can predict scores. The scorer selection algorithms are utilized to help simplify the proposed system. In the final stage, the ensemble method is used to combine the prediction results from selected scorers. Two multiple-scale versions of the proposed approach are also presented along with the single-scale one...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29220316/edge-based-defocus-blur-estimation-with-adaptive-scale-selection
#16
Ali Karaali, Claudio Rosito Jung
Objects that do not lie at the focal distance of a digital camera generate defocused regions in the captured image. This paper presents a new edge-based method for spatially varying defocus blur estimation using a single image based on reblurred gradient magnitudes. The proposed approach initially computes a scale-consistent edge map of the input image and selects a local reblurring scale aiming to cope with noise, edge mis-localization, and interfering edges. An initial blur estimate is computed at the detected scale-consistent edge points and a novel connected edge filter is proposed to smooth the sparse blur map based on pixel connectivity within detected edge contours...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29220175/a-spectroscopic-signature-for-stable-%C3%AE-amyloid-fibrils-versus-%C3%AE-sheet-rich-oligomers
#17
Justin P Lomont, Kacie L Rich, Michał Maj, Jia-Jung Ho, Joshua S Ostrander, Martin T Zanni
We use 2D IR spectroscopy to explore fibril formation for the two predominant isoforms of the β-amyloid (Aβ1-40 and Aβ1-42) protein associated with Alzheimer's disease. 2D IR spectra resolve a transition at 1610 cm-1 in Aβ fibrils that does not appear in other Aβ aggregates, even those with predominantly β-sheet structure like oligomers. This transition is not resolved in linear IR spectroscopy, because it lies under the broad band centered at 1625 cm-1 that is the traditional infrared signature for amy-loid fibrils...
December 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29220055/on-demand-acoustic-droplet-splitting-and-steering-in-a-disposable-microfluidic-chip
#18
Jinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin Sung
On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control droplet volume after production and increase operational capability, flexibility, and throughput. Various droplet splitting methods have been proposed, and among them the acoustic droplet splitting method is promising because of its label-free operation without any physical or thermal damage to droplets. Previous acoustic droplet splitting methods faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel droplet splitting; second, they required irreversible bonding between a piezoelectric substrate and a microfluidic chip, such that the fluidic chip was not replaceable...
December 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29219755/mitochondrial-abnormalities-related-to-the-dysfunction-of-circulating-endothelial-colony-forming-cells-in-moyamoya-disease
#19
Jung Won Choi, Sung Min Son, Inhee Mook-Jung, Youn Joo Moon, Ji Yeoun Lee, Kyu-Chang Wang, Hyun-Seung Kang, Ji Hoon Phi, Seung Ah Choi, Sangjoon Chong, Jayoung Byun, Seung-Ki Kim
OBJECTIVE Moyamoya disease (MMD) is a unique cerebrovascular disorder characterized by the progressive occlusion of the bilateral internal carotid arteries. Endothelial colony-forming cells (ECFCs), previously termed "endothelial progenitor cells," play an important role in the pathogenesis of MMD. In this study, the authors performed morphological and functional studies of the mitochondria of ECFCs from patients with MMD to present new insights into the pathogenesis of the disease. METHODS The morphology of ECFCs from 5 MMD patients and 5 healthy controls was examined under both a transmission electron microscope and a confocal laser scanning microscope...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29219115/thermal-annealing-and-pressure-effects-on-bafe2-x-co-x-as2-single-crystals
#20
Dongwon Shin, Soon-Gil Jung, G Prathiba, Soonbeom Seo, Ki-Young Choi, Kee Hoon Kim, Tuson Park
We investigate the pressure and thermal annealing effects on BaFe2-x Co x As2 (Co-Ba122) single crystals with x  =  0.1 and 0.17 via electrical transport measurements. The thermal annealing treatment not only enhances the superconducting transition temperature (T c) from 9.6 to 12.7 K for x  =  0.1 and from 18.1 to 21.0 K for x  =  0.17, but also increases the antiferromagnetic transition temperature (T N). Simultaneous enhancement of T c and T N by the thermal annealing treatment indicates that thermal annealing could substantially improve the quality of the Co-doped Ba122 samples...
December 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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