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You-Jung Choi, Hyun-Joo Song, Yuyan Luo
The present study examines how infants use their emergent perspective-taking and language comprehension abilities to make sense of interactions between two human agents. In the study, one agent (Agent1) could see only one of two identical balls on an apparatus because of a screen obstructing her view while the infant and another agent (Agent2) could see both balls. 19-month-old English-learning monolingual infants seemed to expect Agent2 to grasp the ball visible to Agent1 when she said to Agent2 "Give me the ball" but not when she said "Give me a ball...
February 20, 2018: Cognition
Yhu-Chering Huang, Chih-Jung Chen, Ching-Chia Kuo, Min-Chi Lu
We identified 27 (0.51%) USA300 isolates from a pool of 5308 meticillin-resistant Staphylococcus aureus (MRSA) isolates collected in Taiwan between 1995 and October 2015, including 12 infecting isolates from 10 patients. The first two isolates were identified in 2005 and 23 isolates since 2010. Phylogenetic analysis revealed all the local isolates were closely related to those in North America and there was a clade consisting of 13 local isolates from 10 patients. MRSA USA300 existed in Taiwan in 2005 or earlier, with increasing identification since 2010...
February 20, 2018: Journal of Hospital Infection
Hui-Shan Shen, Szu-Yin Chen, Denise Shuk Ting Cheung, Shu-Yi Wang, Lee Jung Jae, Chia-Chin Lin
CONTEXT: No study has examined the varying family experience of palliative sedation therapy (PST) for terminally ill patients in different settings. OBJECTIVES: To examine and compare family concerns about PST use and its effect on the grief suffered by terminally ill patients' families in palliative care units (PCU) or intensive care units (ICU). METHODS: A total of 154 family members of such patients were recruited in Taiwan, of whom 143 completed the study, with 81 from the PCU and 62 from the ICU...
February 20, 2018: Journal of Pain and Symptom Management
Jung-Chun Lin
Alternative splicing has been widely demonstrated to function as pivotal regulation in specifying cellular fates and biological functions. The relative expression or cellular localization of a splicing factor constitutes an important mechanism in spatiotemporal programming of cell- and stage-specific splicing profiles. In this study, results of deep RNA-sequencing (RNA-Seq) analyses first revealed the reprogrammed splicing profile and reduced expression of serine/arginine-rich splicing factor protein kinase 1 (SRPK1) throughout the development of brown adipose tissue (BAT)...
February 20, 2018: Biochimica et Biophysica Acta
Ho Cheol Choi, Sung Eun Park, Dae Seob Choi, Hwa Seon Shin, Ji-Eun Kim, Hye Young Choi, Mi Jung Park, Eun Ha Koh
BACKGROUND AND PURPOSE: Rupture of the extracranial carotid artery is a rare, but potentially disastrous event. We aimed to review the clinical presentations and radiologic findings of this entity and to evaluate the efficacy of endovascular treatment with covered stent graft. MATERIALS AND METHODS: Since January 2009, eight patients with extracranial carotid artery rupture received endovascular treatment with covered stent graft. We retrospectively reviewed their medical records and radiologic findings...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Michael Versoza, Wonseok Jung, Mona Loraine Barabad, Yongil Lee, Kyomin Choi, Duckshin Park
The inactivation of viruses that retain their infectivity when transmitted through the air is challenging. To address this issue, this study used a non-contact ultrasound transducer (NCUT) to generate shock waves in the air at specific distances, input voltages, and exposure durations, targeting bacteriophage virus aerosols captured on to H14 HEPA filters. Initially, a frequency of 27.56 kHz (50V) at 25-mm distance was used, which yielded an inactivation efficiency of up to 32.69 ± 12.10%. Other frequencies at shorter distances were investigated, where 29...
February 20, 2018: Journal of Virological Methods
Hansang Lee, Helen Hong, Junmo Kim, Dae Chul Jung
PURPOSE: To develop an automatic deep feature classification (DFC) method for distinguishing benign angiomyolipoma without visible fat (AMLwvf) from malignant clear cell renal cell carcinoma (ccRCC) from abdominal contrast-enhanced computer tomography (CE CT) images. METHODS: A dataset including 80 abdominal CT images of 39 AMLwvf and 41 ccRCC patients was used. We proposed a DFC method for differentiating the small renal masses (SRM) into AMLwvf and ccRCC using the combination of hand-crafted and deep features, and machine learning classifiers...
February 23, 2018: Medical Physics
Jiayu Chen, Vince D Calhoun, Dongdong Lin, Nora I Perrone-Bizzozero, Juan R Bustillo, Godfrey D Pearlson, Steven G Potkin, Theo G M van Erp, Fabio Macciardi, Stefan Ehrlich, Beng-Choon Ho, Scott R Sponheim, Lei Wang, Julia M Stephen, Andrew R Mayer, Faith M Hanlon, Rex E Jung, Brett A Clementz, Matcheri S Keshavan, Elliot S Gershon, John A Sweeney, Carol A Tamminga, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Jessica A Turner, Jingyu Liu
Genetic factors are known to influence both risk for schizophrenia (SZ) and variation in brain structure. A pressing question is whether the genetic underpinnings of brain phenotype and the disorder overlap. Using multivariate analytic methods and focusing on 1,402 common single-nucleotide polymorphisms (SNPs) mapped from the Psychiatric Genomics Consortium (PGC) 108 regions, in 777 discovery samples, we identified 39 SNPs to be significantly associated with SZ-discriminating gray matter volume (GMV) reduction in inferior parietal and superior temporal regions...
February 21, 2018: Schizophrenia Bulletin
Hyuksool Kwon, Yeokoon Kim, Kyuseok Kim, Jae Yun Jung, Joonghee Kim, Sang Il Choi, Eun Ju Chun, Woo Kyung Bae
OBJECTIVE: Patients usually receive cardiopulmonary resuscitation during ventilatory expiration and with their arms down, which does not reflect the normal imaging position. This study used scout images from low-dose chest computed tomography to compare the locations of the left ventricle (LV) in the expiration with arms down position (EAD) and in the full inspirational with arms raised position (IAR). METHODS: This cross-sectional study used a convenience sample and evaluated scout images that were obtained during screening with the participants in the EAD and IAR positions...
2018: PloS One
Shuyu Piao, Jun Wan Lee, Harsha Nagar, Saet-Byel Jung, Sujeong Choi, Seonhee Kim, Ikjun Lee, Sung-Min Kim, Nara Shin, Yu Ran Lee, Sang Do Lee, Jin Bong Park, Kaikobad Irani, Minho Won, Gang Min Hur, Byeong Hwa Jeon, Dong Woon Kim, Cuk-Seong Kim
AIMS: CR6 interacting factor 1 (CRIF1) deficiency impairs mitochondrial oxidative phosphorylation complexes, contributing to increased mitochondrial and cellular reactive oxygen species (ROS) production. CRIF1 downregulation has also been revealed to decrease sirtuin 1 (SIRT1) expression and impair vascular function. Inhibition of SIRT1 disturbs oxidative energy metabolism and stimulates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-induced inflammation. Therefore, we hypothesized that both CRIF1 deficiency-induced mitochondrial ROS production and SIRT1 reduction play stimulatory roles in vascular inflammation...
2018: PloS One
Yangjin Jung, Christopher L Rupert, Benjamin Chapman, Anna C S Porto Fett, John B Luchansky
In total, 115 marinade samples (58 fresh marinades and 57 spent marinades) were collected over 12 months from specialty retailers (four individual stores) near Raleigh, NC. These marinades were screened for total mesophilic aerobic plate count (M-APC), total psychrotrophic aerobic plate count (P-APC), and Enterobacteriaceae. These marinades were also screened for the seven regulated serogroups of Shiga toxin-producing Escherichia coli. Stores A and B used immersion to marinade raw beef cuts, whereas stores C-1 and C-2 used vacuum tumbling...
February 23, 2018: Journal of Food Protection
Jaya Gautam, Suhrid Banskota, Sajita Shah, Jun-Goo Jee, Eunju Kwon, Ying Wang, Dong Young Kim, Hyun Wook Chang, Jung-Ae Kim
BACKGROUND AND PURPOSE: In this study, we examined that 4-hydroxynonenal (4-HNE) acts as a ligand for GPR109A, which elicits both anti-inflammatory and cell death responses. EXPERIMENTAL APPROACH: Agonistic activity of 4-HNE was determined by observing the inhibition of cAMP generation in CHO-K1-GPR109A-Gi cell line, surface plasmon resonance (SPR) binding assay, and competition binding assay with [3 H]niacin. 4-HNE-mediated signaling pathways and cellular responses were investigated in GPR109A-expressing and -non-expressing cells...
February 23, 2018: British Journal of Pharmacology
Oleksiy V Penkov, Mahdi Khadem, Jung-Seung Lee, Mehdi Kheradmandfard, Chang-Lae Kim, Seung-Woo Cho, Dae-Eun Kim
Functional nanocomposite coatings comprised of periodically stacked nanolayers of diamond-like carbon (DLC) and amorphous silicon were developed for biomedical applications. The periodical nanocomposite structure provided high surface durability while silicon aided in reducing the residual stress. The structural, mechanical, tribological, and biomedical properties of the Si/DLC coatings deposited by magnetron sputtering were investigated systematically. The effect of the negative substrate bias on the structure and properties of the coatings was also assessed...
February 23, 2018: Nanoscale
Seulah Lee, Hee Ra Park, Joo Yeon Lee, Jung-Hyun Cho, Hye Min Song, Ah Hyun Kim, Wonjong Lee, Yujeong Lee, Seung-Cheol Chang, Hyung Sik Kim, Jaewon Lee
Acrylamide (ACR) is a neurotoxin known to produce neurotoxicity characterized by ataxia, skeletal muscle weakness, cognitive impairment, and numbness of the extremities. Previously, investigators reported that high-dose (50 mg/kg) ACR impaired hippocampal neurogenesis and increased neural progenitor cell death; however, the influence of subchronic environmentally relevant low dose-(2, 20, or 200 μg/kg) ACRs have not been examined in adult neurogenesis or cognitive function in mice. Accordingly, the aim of the present study was to investigate whether low-dose ACR adversely affected mouse hippocampal neurogenesis and neurocognitive functions...
February 23, 2018: Journal of Toxicology and Environmental Health. Part A
Yeo-Jung Kwon, Nam-Hyeon Cho, Dong-Jin Ye, Hyoung-Seok Baek, Yeon-Sang Ryu, Young-Jin Chun
Cytochrome P450 1B1 (CYP1B1), a well-known oncogene, has garnered wide attention because of its tumor-specific expression pattern and actions as a carcinogenic factor. Although CYP1B1 might play a crucial role in carcinogenesis, the detailed molecular mechanisms underlying oncogenic involvement in cancer development remain unclear. The present study investigated the manner in which CYP1B1 promotes survival of various cancer cells. Treatment with 2,2',4,6'-tetramethoxystilbene (TMS), a specific CYP1B1 inhibitor, significantly inhibited cell viability in human breast cancer and leukemia cell lines, including MCF-7, MDA-MB-231, HL-60, and U937 cells...
February 23, 2018: Journal of Toxicology and Environmental Health. Part A
Jae-Sung Ahn, Ho-Jin Lee, Dae-Jung Choi, Ki-Young Lee, Sung-Jin Hwang
This study was performed to describe the extraforaminal approach of biportal endoscopic spinal surgery (BESS) as a new endoscopic technique for transforaminal decompression and discectomy and to demonstrate the clinical outcomes of this new procedure for the first time. Twenty-one patients (27 segments) who underwent the extraforaminal approach of BESS between March 2015 and April 2016 were enrolled according to the inclusion and exclusion criteria. The operative time (minutes/level) and complications after the procedure were recorded...
February 23, 2018: Journal of Neurosurgery. Spine
Seyoung Jung, Timothy P Lodge, Theresa M Reineke
Complexation between plasmid DNA (pDNA) and a set of diblock copolymers, each with one cationic block and one hydrophilic, charge-neutral block, is examined. A range of hydrophilic block structures are explored, whereas the cationic block is fixed as poly(N-(2-aminoethyl) methacrylamide) (PAEMA) with a degree of polymerization of 60 ± 3. The hydrophilic blocks include poly(ethylene glycol) (PEG45), poly(oligo(ethylene glycol) methyl ether methacrylate) (P(OEGMA)51), and poly(2-deoxy-2-methacrylamido glucopyranose) (PMAG52)...
February 23, 2018: Journal of Physical Chemistry. B
Minkyung Jung, Kenji Yoshida, Kidong Park, Xiao-Xiao Zhang, Can Yesilyurt, Zhuo Bin Siu, Mansoor Bin Abdul Jalil, Jinwan Park, Jeunghee Park, Naoto Nagaosa, Jungpil Seo, Kazuhiko Hirakawa
We demonstrate quantum dot (QD) formation in three-dimensional Dirac semimetal Cd3 As2 nanowires using two electrostatically tuned p-n junctions with a gate and magnetic fields. The linear conductance measured as a function of gate voltage under high magnetic fields is strongly suppressed at the Dirac point close to zero conductance, showing strong conductance oscillations. Remarkably, in this regime, the Cd3 As2 nanowire device exhibits Coulomb diamond features, indicating that a clean single QD forms in the Dirac semimetal nanowire...
February 23, 2018: Nano Letters
Hakyoung Kim, Do Hoon Lim, Tae Gyu Kim, Jung-Il Lee, Do-Hyun Nam, Ho Jun Seol, Doo-Sik Kong, Jung Won Choi, Yeon-Lim Suh, Sung Tae Kim
AIM: Leptomeningeal enhancement (LME) on preoperative brain magnetic resonance imaging (MRI) does not always indicate leptomeningeal seeding (LMS). With Stupp's regimen, authors have treated glioblastoma patients with LME on preoperative brain MRI but here we tried to find the clinical impact of LME. METHODS: From 2005 to 2015, 290 patients with glioblastoma have been treated with Stupp's regimen at Samsung Medical Center. Among these, 33 patients showed LME on preoperative brain MRI...
February 23, 2018: Asia-Pacific Journal of Clinical Oncology
Jung Won Kim, John Torous, Steven Chan, Shih Yee-Marie Tan Gipson
No abstract text is available yet for this article.
February 22, 2018: Academic Psychiatry
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