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https://www.readbyqxmd.com/read/29933500/modulation-of-sonic-hedgehog-induced-mouse-embryonic-stem-cell-behaviors-through-e-cadherin-expression-and-integrin-%C3%AE-1-dependent-f-actin-formation
#1
Ji Young Oh, Han Na Suh, Gee Euhn Choi, Hyun Jik Lee, Young Hyun Jung, So Hee Ko, Jun Sung Kim, Chang Woo Chae, Chang-Kyu Lee, Ho Jae Han
BACKGROUND AND PURPOSE: Sonic hedgehog pathway (Shh) plays a central role in maintaining stem cell function and behavior in various processes related to self-renewal and tissue regeneration. However, the therapeutic effect of Shh on mouse embryonic stem cells (mESCs) has not yet been clearly described. Thus, we investigated the effect of Shh on the regulation of mESC behaviors as well as the effect of Shh-pretreated mESCs in skin wound healing. EXPERIMENTAL APPROACH: The present study investigated the underlying mechanisms of Shh signaling pathway in growth and motility of mESCs using western blot analysis, cell proliferation assay, and cell migration assay...
June 22, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#2
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29932826/proteomic-determination-of-the-lysine-acetylome-and-phosphoproteome-in-the-rat-native-inner-medullary-collecting-duct
#3
Kelly A Hyndman, Chin-Rang Yang, Hyun Jun Jung, Ezigbobiara N Umejiego, Chung-Ling Chou, Mark A Knepper
Phosphorylation and lysine (K)-acetylation are dynamic post-translational modifications of proteins. Previous proteomic studies have identified over 170,000 phosphorylation sites, and 15,000 K-acetylation sites in mammals. We recently reported that the inner medullary collecting duct (IMCD), which functions in the regulation of water-reabsorption, via the actions of vasopressin, expresses many of the enzymes that can modulated K-acetylation. The purpose of this study was to determine the K-acetylated or phosphorylated proteins expressed in IMCD cells...
June 22, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29932697/observation-of-tt-over-%C3%A2-h-production
#4
A M Sirunyan, A Tumasyan, W Adam, F Ambrogi, E Asilar, T Bergauer, J Brandstetter, M Dragicevic, J Erö, A Escalante Del Valle, M Flechl, R Frühwirth, V M Ghete, J Hrubec, M Jeitler, N Krammer, I Krätschmer, D Liko, T Madlener, I Mikulec, N Rad, H Rohringer, J Schieck, R Schöfbeck, M Spanring, D Spitzbart, A Taurok, W Waltenberger, J Wittmann, C-E Wulz, M Zarucki, V Chekhovsky, V Mossolov, J Suarez Gonzalez, E A De Wolf, D Di Croce, X Janssen, J Lauwers, M Pieters, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, S Abu Zeid, F Blekman, J D'Hondt, I De Bruyn, J De Clercq, K Deroover, G Flouris, D Lontkovskyi, S Lowette, I Marchesini, S Moortgat, L Moreels, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, D Beghin, B Bilin, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, B Dorney, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, A K Kalsi, T Lenzi, J Luetic, N Postiau, E Starling, L Thomas, C Vander Velde, P Vanlaer, D Vannerom, Q Wang, T Cornelis, D Dobur, A Fagot, M Gul, I Khvastunov, D Poyraz, C Roskas, D Trocino, M Tytgat, W Verbeke, B Vermassen, M Vit, N Zaganidis, H Bakhshiansohi, O Bondu, S Brochet, G Bruno, C Caputo, P David, C Delaere, M Delcourt, B Francois, A Giammanco, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, K Piotrzkowski, A Saggio, M Vidal Marono, S Wertz, J Zobec, F L Alves, G A Alves, L Brito, M Correa Martins Junior, G Correia Silva, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, E Coelho, E M Da Costa, G G Da Silveira, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, H Malbouisson, D Matos Figueiredo, M Melo De Almeida, C Mora Herrera, L Mundim, H Nogima, W L Prado Da Silva, L J Sanchez Rosas, A Santoro, A Sznajder, M Thiel, E J Tonelli Manganote, F Torres Da Silva De Araujo, A Vilela Pereira, S Ahuja, C A Bernardes, L Calligaris, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, S F Novaes, Sandra S Padula, D Romero Abad, A Aleksandrov, R Hadjiiska, P Iaydjiev, A Marinov, M Misheva, M Rodozov, M Shopova, G Sultanov, A Dimitrov, L Litov, B Pavlov, P Petkov, W Fang, X Gao, L Yuan, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, C H Jiang, D Leggat, H Liao, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, E Yazgan, H Zhang, J Zhao, Y Ban, G Chen, A Levin, J Li, L Li, Q Li, Y Mao, S J Qian, D Wang, Z Xu, Y Wang, C Avila, A Cabrera, C A Carrillo Montoya, L F Chaparro Sierra, C Florez, C F González Hernández, M A Segura Delgado, B Courbon, N Godinovic, D Lelas, I Puljak, T Sculac, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, B Mesic, A Starodumov, T Susa, M W Ather, A Attikis, M Kolosova, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Finger, M Finger, E Ayala, E Carrera Jarrin, H Abdalla, A A Abdelalim, A Mohamed, S Bhowmik, A Carvalho Antunes De Oliveira, R K Dewanjee, K Ehataht, M Kadastik, M Raidal, C Veelken, P Eerola, H Kirschenmann, J Pekkanen, M Voutilainen, J Havukainen, J K Heikkilä, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Laurila, S Lehti, T Lindén, P Luukka, T Mäenpää, H Siikonen, E Tuominen, J Tuominiemi, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, J L Faure, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, C Leloup, E Locci, J Malcles, G Negro, J Rander, A Rosowsky, M Ö Sahin, M Titov, A Abdulsalam, C Amendola, I Antropov, F Beaudette, P Busson, C Charlot, R Granier de Cassagnac, I Kucher, A Lobanov, J Martin Blanco, M Nguyen, C Ochando, G Ortona, P Pigard, R Salerno, J B Sauvan, Y Sirois, A G Stahl Leiton, A Zabi, A Zghiche, J-L Agram, J Andrea, D Bloch, J-M Brom, E C Chabert, V Cherepanov, C Collard, E Conte, J-C Fontaine, D Gelé, U Goerlach, M Jansová, A-C Le Bihan, N Tonon, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, N Chanon, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fay, L Finco, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, H Lattaud, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, V Sordini, M Vander Donckt, S Viret, S Zhang, A Khvedelidze, Z Tsamalaidze, C Autermann, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, M P Rauch, C Schomakers, J Schulz, M Teroerde, B Wittmer, V Zhukov, A Albert, D Duchardt, M Endres, M Erdmann, T Esch, R Fischer, S Ghosh, A Güth, T Hebbeker, C Heidemann, K Hoepfner, H Keller, S Knutzen, L Mastrolorenzo, M Merschmeyer, A Meyer, P Millet, S Mukherjee, T Pook, M Radziej, Y Rath, H Reithler, M Rieger, F Scheuch, A Schmidt, D Teyssier, G Flügge, O Hlushchenko, T Kress, A Künsken, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, D Roy, H Sert, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, I Babounikau, K Beernaert, O Behnke, U Behrens, A Bermúdez Martínez, D Bertsche, A A Bin Anuar, K Borras, V Botta, A Campbell, P Connor, C Contreras-Campana, F Costanza, V Danilov, A De Wit, M M Defranchis, C Diez Pardos, D Domínguez Damiani, G Eckerlin, T Eichhorn, A Elwood, E Eren, E Gallo, A Geiser, J M Grados Luyando, A Grohsjean, P Gunnellini, M Guthoff, M Haranko, A Harb, J Hauk, H Jung, M Kasemann, J Keaveney, C Kleinwort, J Knolle, D Krücker, W Lange, A Lelek, T Lenz, K Lipka, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, M Meyer, M Missiroli, G Mittag, J Mnich, V Myronenko, S K Pflitsch, D Pitzl, A Raspereza, A Saibel, M Savitskyi, P Saxena, P Schütze, C Schwanenberger, R Shevchenko, A Singh, H Tholen, O Turkot, A Vagnerini, G P Van Onsem, R Walsh, Y Wen, K Wichmann, C Wissing, O Zenaiev, R Aggleton, S Bein, L Benato, A Benecke, V Blobel, M Centis Vignali, T Dreyer, E Garutti, D Gonzalez, J Haller, A Hinzmann, A Karavdina, G Kasieczka, R Klanner, R Kogler, N Kovalchuk, S Kurz, V Kutzner, J Lange, D Marconi, J Multhaup, M Niedziela, D Nowatschin, A Perieanu, A Reimers, O Rieger, C Scharf, P Schleper, S Schumann, J Schwandt, J Sonneveld, H Stadie, G Steinbrück, F M Stober, M Stöver, D Troendle, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, M Baselga, S Baur, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, K El Morabit, N Faltermann, B Freund, M Giffels, M A Harrendorf, F Hartmann, S M Heindl, U Husemann, F Kassel, I Katkov, P Keicher, S Kudella, H Mildner, S Mitra, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Waßmer, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, A Kyriakis, D Loukas, G Paspalaki, I Topsis-Giotis, G Karathanasis, S Kesisoglou, P Kontaxakis, A Panagiotou, I Papavergou, N Saoulidou, E Tziaferi, K Vellidis, K Kousouris, I Papakrivopoulos, G Tsipolitis, I Evangelou, C Foudas, P Gianneios, P Katsoulis, P Kokkas, S Mallios, N Manthos, I Papadopoulos, E Paradas, J Strologas, F A Triantis, D Tsitsonis, M Bartók, M Csanad, N Filipovic, P Major, M I Nagy, G Pasztor, O Surányi, G I Veres, G Bencze, C Hajdu, D Horvath, Á Hunyadi, F Sikler, V Veszpremi, G Vesztergombi, T Á Vámi, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, P Raics, Z L Trocsanyi, B Ujvari, S Choudhury, J R Komaragiri, P C Tiwari, S Bahinipati, C Kar, P Mal, K Mandal, A Nayak, D K Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, S Chauhan, R Chawla, N Dhingra, R Gupta, A Kaur, A Kaur, M Kaur, S Kaur, R Kumar, P Kumari, M Lohan, A Mehta, K Sandeep, S Sharma, J B Singh, G Walia, Ashok Kumar, Aashaq Shah, A Bhardwaj, B C Choudhary, R B Garg, M Gola, S Keshri, S Malhotra, M Naimuddin, P Priyanka, K Ranjan, R Sharma, R Bhardwaj, M Bharti, R Bhattacharya, S Bhattacharya, U Bhawandeep, D Bhowmik, S Dey, S Dutt, S Dutta, S Ghosh, K Mondal, S Nandan, A Purohit, P K Rout, A Roy, S Roy Chowdhury, G Saha, S Sarkar, M Sharan, B Singh, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, P K Netrakanti, L M Pant, P Shukla, Ravindra Kumar Verma, T Aziz, M A Bhat, S Dugad, G B Mohanty, N Sur, B Sutar, S Banerjee, S Bhattacharya, S Chatterjee, P Das, M Guchait, Sa Jain, S Karmakar, S Kumar, M Maity, G Majumder, K Mazumdar, N Sahoo, T Sarkar, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, M Khakzad, M Mohammadi Najafabadi, M Naseri, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, A Di Florio, F Errico, L Fiore, A Gelmi, G Iaselli, M Ince, S Lezki, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Zito, G Abbiendi, C Battilana, D Bonacorsi, L Borgonovi, S Braibant-Giacomelli, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, C Ciocca, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, P Giacomelli, C Grandi, L Guiducci, F Iemmi, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, F Primavera, A M Rossi, T Rovelli, G P Siroli, N Tosi, S Albergo, A Di Mattia, R Potenza, A Tricomi, C Tuve, G Barbagli, K Chatterjee, V Ciulli, C Civinini, R D'Alessandro, E Focardi, G Latino, P Lenzi, M Meschini, S Paoletti, L Russo, G Sguazzoni, D Strom, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Ferro, F Ravera, E Robutti, S Tosi, A Benaglia, A Beschi, L Brianza, F Brivio, V Ciriolo, S Di Guida, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, A Massironi, D Menasce, L Moroni, M Paganoni, D Pedrini, S Ragazzi, T Tabarelli de Fatis, D Zuolo, S Buontempo, N Cavallo, A Di Crescenzo, F Fabozzi, F Fienga, G Galati, A O M Iorio, W A Khan, L Lista, S Meola, P Paolucci, C Sciacca, E Voevodina, P Azzi, N Bacchetta, D Bisello, A Boletti, A Bragagnolo, R Carlin, P Checchia, M Dall'Osso, P De Castro Manzano, T Dorigo, F Fanzago, U Gasparini, A Gozzelino, S Y Hoh, S Lacaprara, P Lujan, M Margoni, A T Meneguzzo, J Pazzini, N Pozzobon, P Ronchese, R Rossin, F Simonetto, A Tiko, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, M Ressegotti, C Riccardi, P Salvini, I Vai, P Vitulo, L Alunni Solestizi, M Biasini, G M Bilei, C Cecchi, D Ciangottini, L Fanò, P Lariccia, R Leonardi, E Manoni, G Mantovani, V Mariani, M Menichelli, A Rossi, A Santocchia, D Spiga, K Androsov, P Azzurri, G Bagliesi, L Bianchini, T Boccali, L Borrello, R Castaldi, M A Ciocci, R Dell'Orso, G Fedi, F Fiori, L Giannini, A Giassi, M T Grippo, F Ligabue, E Manca, G Mandorli, A Messineo, F Palla, A Rizzi, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, N Daci, D Del Re, E Di Marco, M Diemoz, S Gelli, E Longo, B Marzocchi, P Meridiani, G Organtini, F Pandolfi, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, F Cenna, S Cometti, M Costa, R Covarelli, N Demaria, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, D Soldi, A Staiano, S Belforte, V Candelise, M Casarsa, F Cossutti, G Della Ricca, F Vazzoler, A Zanetti, D H Kim, G N Kim, M S Kim, J Lee, S Lee, S W Lee, C S Moon, Y D Oh, S Sekmen, D C Son, Y C Yang, H Kim, D H Moon, G Oh, J Goh, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, H S Kim, J Almond, J Kim, J S Kim, H Lee, K Lee, K Nam, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, D Jeon, H Kim, J H Kim, J S H Lee, I C Park, Y Choi, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, A Castaneda Hernandez, J A Murillo Quijada, R Reyes-Almanza, G Ramirez-Sanchez, M C Duran-Osuna, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, R I Rabadan-Trejo, R Lopez-Fernandez, J Mejia Guisao, M Ramirez-Garcia, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, J Eysermans, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, S Bheesette, P H Butler, A Ahmad, M Ahmad, M I Asghar, Q Hassan, H R Hoorani, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, M Szleper, P Traczyk, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, A Pyskir, M Walczak, M Araujo, P Bargassa, C Beirão Da Cruz E Silva, A Di Francesco, P Faccioli, B Galinhas, M Gallinaro, J Hollar, N Leonardo, M V Nemallapudi, J Seixas, G Strong, O Toldaiev, D Vadruccio, J Varela, S Afanasiev, V Alexakhin, P Bunin, M Gavrilenko, A Golunov, I Golutvin, N Gorbounov, V Karjavin, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, M Savina, S Shmatov, V Smirnov, N Voytishin, A Zarubin, V Golovtsov, Y Ivanov, V Kim, E Kuznetsova, P Levchenko, V Murzin, V Oreshkin, I Smirnov, D Sosnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, I Pozdnyakov, G Safronov, A Spiridonov, A Stepennov, V Stolin, M Toms, E Vlasov, A Zhokin, T Aushev, R Chistov, M Danilov, P Parygin, D Philippov, S Polikarpov, E Tarkovskii, V Andreev, M Azarkin, I Dremin, M Kirakosyan, S V Rusakov, A Terkulov, A Baskakov, A Belyaev, E Boos, V Bunichev, M Dubinin, L Dudko, V Klyukhin, O Kodolova, N Korneeva, I Lokhtin, I Miagkov, S Obraztsov, M Perfilov, V Savrin, P Volkov, V Blinov, T Dimova, L Kardapoltsev, D Shtol, Y Skovpen, I Azhgirey, I Bayshev, S Bitioukov, D Elumakhov, A Godizov, V Kachanov, A Kalinin, D Konstantinov, P Mandrik, V Petrov, R Ryutin, S Slabospitskii, A Sobol, S Troshin, N Tyurin, A Uzunian, A Volkov, A Babaev, S Baidali, V Okhotnikov, P Adzic, P Cirkovic, D Devetak, M Dordevic, J Milosevic, J Alcaraz Maestre, I Bachiller, M Barrio Luna, J A Brochero Cifuentes, M Cerrada, N Colino, B De La Cruz, A Delgado Peris, C Fernandez Bedoya, J P Fernández Ramos, J Flix, M C Fouz, O Gonzalez Lopez, S Goy Lopez, J M Hernandez, M I Josa, D Moran, A Pérez-Calero Yzquierdo, J Puerta Pelayo, I Redondo, L Romero, M S Soares, A Triossi, A Álvarez Fernández, C Albajar, J F de Trocóniz, J Cuevas, C Erice, J Fernandez Menendez, S Folgueras, I Gonzalez Caballero, J R González Fernández, E Palencia Cortezon, V Rodríguez Bouza, S Sanchez Cruz, P Vischia, J M Vizan Garcia, I J Cabrillo, A Calderon, B Chazin Quero, J Duarte Campderros, M Fernandez, P J Fernández Manteca, J Garcia-Ferrero, A García Alonso, G Gomez, A Lopez Virto, J Marco, C Martinez Rivero, P Martinez Ruiz Del Arbol, F Matorras, J Piedra Gomez, C Prieels, T Rodrigo, A Ruiz-Jimeno, L Scodellaro, N Trevisani, I Vila, R Vilar Cortabitarte, D Abbaneo, B Akgun, E Auffray, P Baillon, A H Ball, D Barney, J Bendavid, M Bianco, A Bocci, C Botta, E Brondolin, T Camporesi, M Cepeda, G Cerminara, E Chapon, Y Chen, G Cucciati, D d'Enterria, A Dabrowski, V Daponte, A David, A De Roeck, N Deelen, M Dobson, M Dünser, N Dupont, A Elliott-Peisert, P Everaerts, F Fallavollita, D Fasanella, G Franzoni, J Fulcher, W Funk, D Gigi, A Gilbert, K Gill, F Glege, M Guilbaud, D Gulhan, J Hegeman, V Innocente, A Jafari, P Janot, O Karacheban, J Kieseler, A Kornmayer, M Krammer, C Lange, P Lecoq, C Lourenço, L Malgeri, M Mannelli, F Meijers, J A Merlin, S Mersi, E Meschi, P Milenovic, F Moortgat, M Mulders, J Ngadiuba, S Orfanelli, L Orsini, F Pantaleo, L Pape, E Perez, M Peruzzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, F M Pitters, D Rabady, A Racz, T Reis, G Rolandi, M Rovere, H Sakulin, C Schäfer, C Schwick, M Seidel, M Selvaggi, A Sharma, P Silva, P Sphicas, A Stakia, J Steggemann, M Tosi, D Treille, A Tsirou, V Veckalns, W D Zeuner, L Caminada, K Deiters, W Erdmann, R Horisberger, Q Ingram, H C Kaestli, D Kotlinski, U Langenegger, T Rohe, S A Wiederkehr, M Backhaus, L Bäni, P Berger, N Chernyavskaya, G Dissertori, M Dittmar, M Donegà, C Dorfer, C Grab, C Heidegger, D Hits, J Hoss, T Klijnsma, W Lustermann, R A Manzoni, M Marionneau, M T Meinhard, F Micheli, P Musella, F Nessi-Tedaldi, J Pata, F Pauss, G Perrin, L Perrozzi, S Pigazzini, M Quittnat, D Ruini, D A Sanz Becerra, M Schönenberger, L Shchutska, V R Tavolaro, K Theofilatos, M L Vesterbacka Olsson, R Wallny, D H Zhu, T K Aarrestad, C Amsler, D Brzhechko, M F Canelli, A De Cosa, R Del Burgo, S Donato, C Galloni, T Hreus, B Kilminster, I Neutelings, D Pinna, G Rauco, P Robmann, D Salerno, K Schweiger, C Seitz, Y Takahashi, A Zucchetta, Y H Chang, K Y Cheng, T H Doan, Sh Jain, R Khurana, C M Kuo, W Lin, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y Chao, K F Chen, P H Chen, W-S Hou, Y Y Li, Y F Liu, R-S Lu, E Paganis, A Psallidas, A Steen, B Asavapibhop, N Srimanobhas, N Suwonjandee, A Bat, F Boran, S Cerci, S Damarseckin, Z S Demiroglu, F Dolek, C Dozen, I Dumanoglu, S Girgis, G Gokbulut, Y Guler, E Gurpinar, I Hos, C Isik, E E Kangal, O Kara, A Kayis Topaksu, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, D Sunar Cerci, B Tali, U G Tok, S Turkcapar, I S Zorbakir, C Zorbilmez, B Isildak, G Karapinar, M Yalvac, M Zeyrek, I O Atakisi, E Gülmez, M Kaya, O Kaya, S Tekten, E A Yetkin, M N Agaras, S Atay, A Cakir, K Cankocak, Y Komurcu, S Sen, B Grynyov, L Levchuk, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, O Davignon, H Flacher, J Goldstein, G P Heath, H F Heath, L Kreczko, D M Newbold, S Paramesvaran, B Penning, T Sakuma, D Smith, V J Smith, J Taylor, A Titterton, K W Bell, A Belyaev, C Brew, R M Brown, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Linacre, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, W J Womersley, G Auzinger, R Bainbridge, P Bloch, J Borg, S Breeze, O Buchmuller, A Bundock, S Casasso, D Colling, L Corpe, P Dauncey, G Davies, M Della Negra, R Di Maria, Y Haddad, G Hall, G Iles, T James, M Komm, C Laner, L Lyons, A-M Magnan, S Malik, A Martelli, J Nash, A Nikitenko, V Palladino, M Pesaresi, A Richards, A Rose, E Scott, C Seez, A Shtipliyski, T Strebler, S Summers, A Tapper, K Uchida, T Virdee, N Wardle, D Winterbottom, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, C K Mackay, A Morton, I D Reid, L Teodorescu, S Zahid, K Call, J Dittmann, K Hatakeyama, H Liu, C Madrid, B Mcmaster, N Pastika, C Smith, R Bartek, A Dominguez, A Buccilli, S I Cooper, C Henderson, P Rumerio, C West, D Arcaro, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, X Coubez, D Cutts, M Hadley, J Hakala, U Heintz, J M Hogan, K H M Kwok, E Laird, G Landsberg, J Lee, Z Mao, M Narain, S Piperov, S Sagir, R Syarif, E Usai, D Yu, R Band, C Brainerd, R Breedon, D Burns, M Calderon De La Barca Sanchez, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, W Ko, O Kukral, R Lander, M Mulhearn, D Pellett, J Pilot, S Shalhout, M Shi, D Stolp, D Taylor, K Tos, M Tripathi, Z Wang, F Zhang, M Bachtis, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, S Regnard, D Saltzberg, C Schnaible, V Valuev, E Bouvier, K Burt, R Clare, J W Gary, S M A Ghiasi Shirazi, G Hanson, G Karapostoli, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, W Si, L Wang, H Wei, S Wimpenny, B R Yates, J G Branson, S Cittolin, M Derdzinski, R Gerosa, D Gilbert, B Hashemi, A Holzner, D Klein, G Kole, V Krutelyov, J Letts, M Masciovecchio, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, M Citron, A Dishaw, V Dutta, M Franco Sevilla, L Gouskos, R Heller, J Incandela, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, S Wang, J Yoo, D Anderson, A Bornheim, J M Lawhorn, H B Newman, T Q Nguyen, M Spiropulu, J R Vlimant, R Wilkinson, S Xie, Z Zhang, R Y Zhu, M B Andrews, T Ferguson, T Mudholkar, M Paulini, M Sun, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, S Leontsinis, E MacDonald, T Mulholland, K Stenson, K A Ulmer, S R Wagner, J Alexander, J Chaves, Y Cheng, J Chu, A Datta, K Mcdermott, N Mirman, J R Patterson, D Quach, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, S Abdullin, M Albrow, M Alyari, G Apollinari, A Apresyan, A Apyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, A Canepa, G B Cerati, H W K Cheung, F Chlebana, M Cremonesi, J Duarte, V D Elvira, J Freeman, Z Gecse, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, M J Kortelainen, B Kreis, S Lammel, D Lincoln, R Lipton, M Liu, T Liu, J Lykken, K Maeshima, J M Marraffino, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, A Savoy-Navarro, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, L Cadamuro, A Carnes, M Carver, D Curry, R D Field, S V Gleyzer, B M Joshi, J Konigsberg, A Korytov, P Ma, K Matchev, H Mei, G Mitselmakher, K Shi, D Sperka, J Wang, S Wang, Y R Joshi, S Linn, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, C Schiber, V Sharma, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, M Rahmani, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, S Dittmer, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, C Mills, I D Sandoval Gonzalez, M B Tonjes, N Varelas, H Wang, X Wang, Z Wu, J Zhang, M Alhusseini, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, W T Hung, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, A Bylinkin, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Rogan, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, S Duric, A Ivanov, K Kaadze, D Kim, Y Maravin, D R Mendis, T Mitchell, A Modak, A Mohammadi, L K Saini, N Skhirtladze, F Rebassoo, D Wright, A Baden, O Baron, A Belloni, S C Eno, Y Feng, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, K Wong, D Abercrombie, B Allen, V Azzolini, A Baty, G Bauer, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, P Harris, D Hsu, M Hu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y-J Lee, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, G S F Stephans, K Sumorok, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, S Zhaozhong, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, S Kalafut, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, J Turkewitz, M A Wadud, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, F Golf, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, A Godshalk, C Harrington, I Iashvili, A Kharchilava, C Mclean, D Nguyen, A Parker, S Rappoccio, B Roozbahani, E Barberis, C Freer, A Hortiangtham, D M Morse, T Orimoto, R Teixeira De Lima, T Wamorkar, B Wang, A Wisecarver, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, M H Schmitt, K Sung, M Trovato, M Velasco, R Bucci, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, W Li, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, P Siddireddy, G Smith, S Taroni, M Wayne, A Wightman, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, A Lefeld, T Y Ling, W Luo, B L Winer, H W Wulsin, S Cooperstein, P Elmer, J Hardenbrook, S Higginbotham, A Kalogeropoulos, D Lange, M T Lucchini, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, J Salfeld-Nebgen, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, L Gutay, M Jones, A W Jung, A Khatiwada, B Mahakud, D H Miller, N Neumeister, C C Peng, H Qiu, J F Schulte, J Sun, F Wang, R Xiao, W Xie, T Cheng, J Dolen, N Parashar, Z Chen, K M Ecklund, S Freed, F J M Geurts, M Kilpatrick, W Li, B Michlin, B P Padley, J Roberts, J Rorie, W Shi, Z Tu, J Zabel, A Zhang, A Bodek, P de Barbaro, R Demina, Y T Duh, J L Dulemba, C Fallon, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, R Taus, M Verzetti, A Agapitos, J P Chou, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, J Heideman, G Riley, S Spanier, K Thapa, O Bouhali, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, S Luo, R Mueller, R Patel, A Perloff, L Perniè, D Rathjens, A Safonov, N Akchurin, J Damgov, F De Guio, P R Dudero, S Kunori, K Lamichhane, S W Lee, T Mengke, S Muthumuni, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, J D Ruiz Alvarez, P Sheldon, S Tuo, J Velkovska, M Verweij, Q Xu, M W Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, K Long, R Loveless, T Ruggles, A Savin, N Smith, W H Smith, N Woods
The observation of Higgs boson production in association with a top quark-antiquark pair is reported, based on a combined analysis of proton-proton collision data at center-of-mass energies of sqrt[s]=7, 8, and 13 TeV, corresponding to integrated luminosities of up to 5.1, 19.7, and 35.9  fb^{-1}, respectively. The data were collected with the CMS detector at the CERN LHC. The results of statistically independent searches for Higgs bosons produced in conjunction with a top quark-antiquark pair and decaying to pairs of W bosons, Z bosons, photons, τ leptons, or bottom quark jets are combined to maximize sensitivity...
June 8, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29932657/chemical-constituents-of-apios-americana-tubers-and-their-inhibitory-activities-on-nitric-oxide-production-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#5
Young Hye Seo, Ju-Hyun Jeon, Miran Jeong, Seung Mok Ryu, Won Kyung Jeon, Dae Sik Jang, Sang Hee Shim, Dongho Lee, Jung-Hye Choi, Jun Lee
Apios americana is an important food crop producing edible tubers with high nutritional and medicinal values and is widely cultivated in many countries. Despite its usefulness, research on its secondary metabolites and biological activities has been limited. In the present study, a new coumaronochromone, (2 R,3 S)-3,7,4'-trihydroxy-5-methoxycoumaronochromone (1), and two new isoflavone glucosides, 7,2',4'-trihydroxy-5-methoxyisoflavone-4'- O-β-d-glucopyranoside (3) and 5,7,4'-trihydroxyisoflavone-7- O-β-d-gentiotrioside (5), were isolated from the tubers of A...
June 22, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29932413/pharmacokinetics-and-bioequivalence-of-0-5-mg-lobeglitazone-tablets-in-healthy-male-subjects
#6
So Jin Lee, Min-Gul Kim, Shin-Jung Park, Ji-Young Jeon
OBJECTIVE: This study was conducted to evaluate the pharmacokinetics and bioequivalence of two formulations of -DuvieTM (0.5-mg lobeglitazone sulfate). MATERIALS AND METHODS: This study was designed as an open-label, randomized, single-dose, crossover bioequivalence study in healthy male subjects. A total of 28 subjects were randomized into two groups: one group received the test drug, 0.5-mg DuvieTM tablets, which have formulations available on the global market; and the other group received the reference drug, the initially-approved 0...
June 22, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29932142/integrating-refined-kano-model-and-qfd-for-service-quality-improvement-in-healthy-fast-food-chain-restaurants
#7
Kai-Jung Chen, Tsu-Ming Yeh, Fan-Yun Pai, Der-Fa Chen
People are paying greater attention to health. To maintain a good health status and obtain food fast, customers may go to healthy fast-food chain restaurants such as Subway more often than before in China and Taiwan. Healthy fast-food chain restaurants come with a healthy spin, seeking to differentiate themselves from other fast-food restaurants. This paper combined the refined Kano model and the quality function deployment (QFD) method. The refined Kano model was used to understand how customers perceive service attributes developed based on DINESERV measurements...
June 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29932111/protective-effect-of-octylmethoxycinnamate-against-uv-induced-photoaging-in-hairless-mouse-via-the-regulation-of-matrix-metalloproteinases
#8
So Young Kim, Santosh Lamichhane, Jung-Hun Ju, Jaesuk Yun
Ultraviolet (UV) irradiation damages skin and produces symptoms of photoaging, such as thickening, rough texture, wrinkles, and pigmentation. However, the cellular and molecular mechanisms underlying photoaging induced by chronic UV irradiation are not yet fully understood. Matrix metalloproteinases (MMPs) have been reported to be involved in the response to UV irradiation. In this study, we examined the effects of the sunscreen agent Octylmethoxycinnamate (OMC) on photoaging of the skin induced by chronic UV exposure in hairless albino Crl:SKH1- Hrhr (SKH-1) mice...
June 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29932110/dpie-2-1-2-diphenyl-1h-indol-3-yl-ethanamine-augments-pro-inflammatory-cytokine-production-in-il-1%C3%AE-stimulated-primary-human-oral-cells
#9
Sun-Hee Ahn, Jin-Kyung Lee, Nam Doo Kim, Seok-Ho Kim, Sunwoo Lee, Seunggon Jung, Kee-Oh Chay, Tae-Hoon Lee
Interleukin-1&beta; (IL-1&beta;) is a prominent pro-inflammatory cytokine that is implicated in a variety of autoimmune diseases and plays an important role in host defense against infections. IL-1&beta; activity increases with its increasing binding capacity to IL-1 receptors (IL-1Rs). Thus, numerous studies have targeted the discovery of molecules modulating the interactions between IL-1&beta; and IL-1R1. We have conducted an IL-1R1 structure-based virtual screening to identify small molecules that could alter IL-1&beta; activity, using in silico computational analysis...
June 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29932007/relationships-of-obesity-related-behavior-patterns-with-socioeconomic-status-and-acculturation-in-korean-american-women
#10
Myoungock Jang, Sangchoon Jeon, Soohyun Nam, Hee-Jung Song, Robin Whittemore
There is limited understanding about the obesity-related behaviors of diet, physical activity, and sedentary behavior in Korean American women. The purpose of this study was to cluster obesity-related behavior patterns of Korean American women and to examine group differences in acculturation, socioeconomic status (SES), and body mass index (BMI). A secondary analysis from a cross-sectional study was conducted using two-step cluster analysis for clustering groups. A total of 137 Korean American women ( M age = 42...
June 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29931800/opening-the-selectivity-pocket-in-the-human-lysine-deacetylase-sirtuin2-new-opportunities-new-questions
#11
REVIEW
Dina Robaa, Daria Monaldi, Nathalie Wössner, Norio, Kudo, Tobias Rumpf, Matthias Schiedel, Minoru Yoshida, Manfred Jung
Reversible lysine deacetylation is exerted by both zinc and NAD+ -dependent deacetylases. It is an important factor in epigenetic regulation and more generally in the posttranslational regulation of protein stability, association and activity. Some of these enzymes can also cleave off fatty acids or dicarboxylic acids from lysines in proteins. The NAD+ -dependent deacetylases are termed Sirtuins and are implicated in the pathogenesis of different diseases. For the isotype Sirt2 highly selective inhibitors have been identified in the last few years...
June 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29931791/bronchoalveolar-lavage-affects-computed-tomographic-and-radiographic-characteristics-of-the-lungs-in-healthy-dogs
#12
Sohee Lim, Suneui Sung, Kyungjun Min, Yechan Jung, Youngkwon Cho, Kichang Lee
Bronchoalveolar lavage is a common diagnostic test for dogs with suspected pulmonary disease, however there is no published information on whether this procedure could affect the imaging characteristics of the lungs. Aims of this prospective experimental study were to describe computed tomography (CT) and radiographic features of the lungs after bronchoalveolar lavage in a sample of healthy dogs. Thoracic CT and radiographic images of eight healthy Beagles were acquired at the following time points: before bronchoalveolar lavage, immediately following bronchoalveolar lavage, and at 2, 4, 8, 12, and 24 h following bronchoalveolar lavage...
June 21, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29931651/ptpn6-regulates-the-cell-surface-expression-of-trpm4-channels-in-hek293-cells
#13
Dong Kun Lee, Jung Yeon Park, Jae Cheal Yoo, Eun Hye Byun, Yeon-Ju Bae, Young-Sun Lee, Nammi Park, Dawon Kang, Jaehee Han, Jae Yong Park, Eunmi Hwang, Seong-Geun Hong
Transient receptor-potential, cation channel, subfamily M, member 4 (TRPM4) channels regulate a variety of physiological and pathological processes; however, their roles as functional channels under diverse conditions remain unclear. In this study, cytosolic protein tyrosine phosphatase non-receptor type 6 (PTPN6) interacted with TRPM4 channels. We confirmed their interaction by performing co-immunoprecipitation (Co-IP) assays following heterologous PTPN6 and TRPM4 channel expression in HEK293 cells. Furthermore, biomolecular fluorescence complementation (BiFC) image analysis confirmed TRPM4-PTPN6 binding...
June 21, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29931596/redistribution-of-mature-smooth-muscle-markers-in-brain-arteries-in-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#14
John R Gatti, Xiaojie Zhang, Ejona Korcari, Soo Jung Lee, Nya Greenstone, Jon G Dean, Snehaa Maripudi, Michael M Wang
Vascular smooth muscle cells (SMCs) undergo a series of dramatic changes in CADASIL, the most common inherited cause of vascular dementia and stroke. NOTCH3 protein accumulates and aggregates early in CADASIL, followed by loss of mature SMCs from the media of brain arteries and marked intimal proliferation. Similar intimal thickening is seen in peripheral arterial disease, which features pathological intimal cells including proliferative, dedifferentiated, smooth muscle-like cells deficient in SMC markers. Limited studies have been performed to investigate the differentiation state and location of SMCs in brain vascular disorders...
June 22, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29931561/ct-prediction-of-resectability-and-prognosis-in-patients-with-pancreatic-ductal-adenocarcinoma-after-neoadjuvant-treatment-using-image-findings-and-texture-analysis
#15
Bo Ram Kim, Jung Hoon Kim, Su Joa Ahn, Ijin Joo, Seo-Youn Choi, Sang Joon Park, Joon Koo Han
OBJECTIVES: To assess utility of CT findings and texture analysis for predicting the resectability and prognosis in patients after neoadjuvant therapy for pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS: Among 308 patients, 45 with PDAC underwent neoadjuvant therapy (concurrent-chemoradiation-therapy, CCRT, n = 27 and chemotherapy, ChoT, n = 18) before surgery were included. All underwent baseline and preoperative CT. Two reviewers assessed CT findings and resectability...
June 21, 2018: European Radiology
https://www.readbyqxmd.com/read/29931481/thirteen-year-experience-of-laparoscopic-sleeve-gastrectomy-surgical-risk-weight-loss-and-revision-procedures
#16
Der-Ming Chang, Wei-Jei Lee, Jung-Chien Chen, Kong-Han Ser, Pei-Ling Tsai, Yi-Chih Lee
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remains lacking. METHODS: A total of 1759 LSG was performed as primary bariatric procedure from 2005 to 2017 with mean age of 35.2 ± 10.3 years old (14-71), female 69.7%, mean body mass index (BMI) 37.9 ± 7.7 kg/m2 , and mean waist width 113.7 ± 17.9 cm. All patients were evaluated and managed under a strict multidisciplinary team approach...
June 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29931426/validation-of-the-new-ajcc-eighth-edition-of-the-tnm-classification-for-breast-cancer-with-a-single-center-breast-cancer-cohort
#17
Ji-Yeon Kim, Ji Eun Lim, Hae Hyun Jung, Soo Youn Cho, Eun Yoon Cho, Se Kyung Lee, Jong Han Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im
PURPOSE: The new eighth edition TNM classification by the AJCC for breast cancer (BC) incorporates biologic factors and gene expression prognostic panels, in addition to traditional anatomic factors. In this study, we evaluated the prognostic value of this new staging system compared to the previous AJCC 7th edition staging system. METHODS: We conducted a retrospective analysis of women with stage I, II, or III BC who underwent curative surgery with/without adjuvant systemic therapy at Samsung Medical Center between July 2004 and December 2008...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29931224/long-term-risk-of-hypertension-in-normoglycemia-and-prediabetes-and-their-relation-to-the-change-of-glycemic-state
#18
Ju Young Jung, Chang-Mo Oh, Joong-Myung Choi, Jae-Hong Ryoo, Sung Keun Park
Background: Although increasing evidence has suggested the significant association between dysglycemia and hypertension, this association is less well described in prediabetes. Additionally, it is unclear how risk of hypertension varies according to the change of glycemic state. Methods: 5,413 non-diabetic Koreans were dichotomized into normoglycemia (NG) and prediabetes group and followed-up for 10 years. Cox proportional hazard model was used to evaluate hazard ratios (HRs) with 95% confidence interval (CI) [adjusted HRs (95% CI)] for the development of hypertension...
June 21, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29930785/comparative-study-of-new-bone-formation-capability-of-zirconia-bone-graft-material-in-rabbit-calvarial
#19
Ik-Jung Kim, Soo-Yeon Shin
PURPOSE: The purpose of this study was to compare the new bone formation capability of zirconia with those of other synthetic bone grafts. MATERIALS AND METHODS: Twelve rabbits were used and four 6-mm diameter transcortical defects were formed on each calvaria. Each defect was filled with Osteon II (Os), Tigran PTG (Ti), and zirconia (Zi) bone grafts. For the control group, the defects were left unfilled. The rabbits were sacrificed at 2, 4, and 8 weeks. Specimens were analyzed through micro computed tomography (CT) and histomorphometric analysis...
June 2018: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29930524/longitudinal-changes-in-neural-connectivity-in-patients-with-internet-gaming-disorder-a-resting-state-eeg-coherence-study
#20
Sunyoung Park, Hyera Ryu, Ji-Yoon Lee, Aruem Choi, Dai-Jin Kim, Sung Nyun Kim, Jung-Seok Choi
Aims: The present study investigated neural connectivity associated with treatment responses in patients with Internet gaming disorder (IGD) using resting-state electroencephalography (EEG) coherence analyses. Methods: We included 30 patients with IGD and 32 healthy control subjects (HCs). Of the IGD patients, 18 completed an outpatient treatment that included pharmacotherapy with selective serotonin reuptake inhibitors for 6 months. Resting-state EEG coherence and self-report questionnaires were used to evaluate clinical and psychological features pre- and post-treatment, and data were analyzed using generalized estimating equations...
2018: Frontiers in Psychiatry
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