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https://www.readbyqxmd.com/read/28317249/getting-back-to-the-dissecting-room-an-evaluation-of-an-innovative-course-in-musculoskeletal-anatomy-for-uk-based-rheumatology-training
#1
Tim Blake, Debbi Marais, Andrew B Hassell, Kay Stevenson, Zoe Paskins
BACKGROUND: The rheumatologist relies heavily on clinical skills to diagnose diverse conditions, something that is correlated with one's knowledge of clinical anatomy. More recently, rheumatology has offered further career flexibility with opportunities to develop skills such as joint injection and musculoskeletal (MSK) ultrasound, both of which require a sound understanding of anatomy. Currently, there are no formal strategies to support competency-based anatomy learning in rheumatology in the UK...
March 20, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28301204/impact-of-an-interactive-diagnostic-case-simulator-on-a-medical-student-radiology-rotation
#2
Michael V Friedman, Jennifer L Demertzis, Travis J Hillen, Jeremiah R Long, David A Rubin
OBJECTIVE: The objective of our study was to assess the short-term impact of adding an interactive simulator to a medical student radiology clerkship. We hypothesized that transitioning students from passive observers to active participants in the reading room would create an appealing and effective learning experience for the current generation of students. MATERIALS AND METHODS: An interactive workstation that provided diagnostic simulations of 84 cases selected to maximize exposure to important diagnoses in musculoskeletal (MSK) radiology was created...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28298524/novel-noncatalytic-substrate-selective-p38%C3%AE-specific-mapk-inhibitors-with-endothelial-stabilizing-and-anti-inflammatory-activity
#3
Nirav G Shah, Mohan E Tulapurkar, Aparna Ramarathnam, Amanda Brophy, Ramon Martinez, Kellie Hom, Theresa Hodges, Ramin Samadani, Ishwar S Singh, Alexander D MacKerell, Paul Shapiro, Jeffrey D Hasday
The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory diseases, but the currently available p38 catalytic inhibitors (e.g., SB203580) are poorly effective and cause toxicity. We reasoned that the failure of catalytic p38 inhibitors may derive from their activity against noninflammatory p38 isoforms (e.g., p38β/MAPK11) and loss of all p38α-dependent responses, including anti-inflammatory, counterregulatory responses via mitogen- and stress-activated kinase (MSK) 1/2 and Smad3...
March 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28290926/soldier-readiness-processing-time-for-a-new-paradigm-in-managing-musculoskeletal-injuries-after-deployment
#4
Daniel I Rhon, Kerrie J Golden, Amy J Trevino, Brian S Hatler
BACKGROUND: The drowning impact that musculoskeletal injuries (MSI) have on Soldier readiness, deployability, and escalating health care costs is growing. These injuries are associated with approximately 25 million lost duty days each year. The need to curb costs and improve efficacy and efficiency of health care delivery is pressing. This requires the consideration of new paradigms for clinical pathways and health care delivery processes. Soldiers returning from a deployment go through a screening process to ensure any medical, dental, and administrative issues are adequately addressed...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28285846/a-comparative-analysis-of-prediction-models-for-complete-gross-resection-in-secondary-cytoreductive-surgery-for-ovarian-cancer
#5
Renee A Cowan, Ane Gerda Zahl Eriksson, Sara M Jaber, Qin Zhou, Alexia Iasonos, Oliver Zivanovic, Mario M Leitao, Nadeem R Abu-Rustum, Dennis S Chi, Ginger J Gardner
OBJECTIVE: We sought to examine compliance and outcomes using Memorial Sloan Kettering "(MSK) criteria" to predict complete gross resection (CGR) and compare them with the validated Tian and AGO models. METHODS: Patients who underwent SCS for recurrent platinum-sensitive ovarian cancer from 5/2001-6/2014 were identified. The AGO and Tian models were applied to the study population; appropriate statistical tests were used to determine ability to predict CGR. RESULTS: 214 SCS cases were identified...
March 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28271400/the-effect-of-self-efficacy-on-return-to-work-outcomes-for-workers-with-psychological-or-upper-body-musculoskeletal-injuries-a-review-of-the-literature
#6
REVIEW
Oliver Black, Tessa Keegel, Malcolm R Sim, Alexander Collie, Peter Smith
Purpose Work absence can result in substantial losses to the economy and workers. As a result, identifying modifiable factors associated with return-to-work (RTW) following an injury or illness is the focus of many empirical investigations. Self-efficacy, the belief about one's ability to undertake behaviours to achieve desired goals, has been identified as an important factor in RTW for injured workers. This paper systematically reviewed the literature on the association between self-efficacy and RTW outcomes for workers with an upper-body musculoskeletal injury or psychological injury...
March 7, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28259850/blood-flow-restriction-training-in-clinical-musculoskeletal-rehabilitation-a-systematic-review-and-meta-analysis
#7
REVIEW
Luke Hughes, Bruce Paton, Ben Rosenblatt, Conor Gissane, Stephen David Patterson
BACKGROUND AND OBJECTIVE: Low-load exercise training with blood flow restriction (BFR) can increase muscle strength and may offer an effective clinical musculoskeletal (MSK) rehabilitation tool. The aim of this review was to systematically analyse the evidence regarding the effectiveness of this novel training modality in clinical MSK rehabilitation. DESIGN: This is a systematic review and meta-analysis of peer-reviewed literature examining BFR training in clinical MSK rehabilitation (Research Registry; researchregistry91)...
March 4, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28253529/comparative-effectiveness-research-in-musculoskeletal-imaging
#8
Shadpour Demehri, Michael P Recht, Christoph I Lee
The primary goal of comparative effectiveness research (CER) is to define the optimal choice among alternative diagnostic and interventional strategies for a given clinical scenario among major stakeholders in the health care system. In an era where health care decision makers are demanding greater evidence of improved patient outcomes from the use of medical technologies, musculoskeletal (MSK) imagers must be more engaged in generating quality CER. We provide an overview of CER and its expanding role in U...
February 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28253526/measuring-value-outcomes-and-cost-effectiveness-in-msk-radiology-a-primer
#9
Soterios Gyftopoulos, Naveen Subhas
No abstract text is available yet for this article.
February 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28250137/mortality-from-musculoskeletal-disorders-including-rheumatoid-arthritis-in-southern-sweden-a-multiple-cause-of-death-analysis-1998-2014
#10
Aliasghar A Kiadaliri, Aleksandra Turkiewicz, Martin Englund
OBJECTIVE: To assess mortality related to musculoskeletal (MSK) disorders and rheumatoid arthritis (RA), specifically, among adults (aged ≥ 20 yrs) in southern Sweden using the multiple-cause-of-death approach. METHODS: All death certificates (DC; n = 201,488) from 1998 to 2014 for adults in the region of Skåne were analyzed when mortality from MSK disorders and RA was listed as the underlying and nonunderlying cause of death (UCD/NUCD). Trends in age-standardized mortality rates (ASMR) were evaluated using joinpoint regression, and associated causes were identified by age- and sex-adjusted observed/expected ratios...
March 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28249984/adult-muscle-formation-requires-drosophila-moleskin-for-proliferation-of-wing-disc-associated-muscle-precursors
#11
Kumar Vishal, David S Brooks, Simranjot Bawa, Samantha Gameros, Marta Stetsiv, Erika R Geisbrecht
Adult muscle precursor (AMP) cells located in the notum of the larval wing disc undergo rapid amplification and eventual fusion to generate the Drosophila melanogaster indirect flight muscles (IFMs). Here we find that loss of Moleskin (Msk) function in these wing disc-associated myoblasts reduces the overall AMP pool size, resulting in the absence of IFM formation. This myoblast loss is due to a decrease in the AMP proliferative capacity and is independent of cell death. In contrast, disruption of Msk during pupal myoblast proliferation does not alter the AMP number, suggesting that Msk is specifically required for larval AMP proliferation...
March 1, 2017: Genetics
https://www.readbyqxmd.com/read/28228698/current-and-prospective-use-of-musculoskeletal-diagnostic-ultrasound-imaging-at-chiropractic-teaching-institutions-a-worldwide-survey-of-diagnostic-imaging-staff
#12
Rogan E A Henderson, Bruce F Walker, Kenneth J Young
OBJECTIVE: The purpose of this study was to survey the use of musculoskeletal diagnostic ultrasound imaging (MSK-DUSI) at chiropractic educational programs worldwide and to elicit opinions of academic diagnostic imaging staff of its prospective use at their teaching institutions. METHODS: An electronic questionnaire was delivered in 2014 using SurveyMonkey and notifications were disseminated by e-mail to 127 diagnostic imaging staff at chiropractic programs worldwide...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28224415/effectiveness-of-workplace-interventions-in-return-to-work-for-musculoskeletal-pain-related-and-mental-health-conditions-an-update-of-the-evidence-and-messages-for-practitioners
#13
REVIEW
K L Cullen, E Irvin, A Collie, F Clay, U Gensby, P A Jennings, S Hogg-Johnson, V Kristman, M Laberge, D McKenzie, S Newnam, A Palagyi, R Ruseckaite, D M Sheppard, S Shourie, I Steenstra, D Van Eerd, B C Amick
Purpose The objective of this systematic review was to synthesize evidence on the effectiveness of workplace-based return-to-work (RTW) interventions and work disability management (DM) interventions that assist workers with musculoskeletal (MSK) and pain-related conditions and mental health (MH) conditions with RTW. Methods We followed a systematic review process developed by the Institute for Work & Health and an adapted best evidence synthesis that ranked evidence as strong, moderate, limited, or insufficient...
February 21, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28187999/intraobserver-and-interobserver-variability-of-the-bone-marrow-burden-bmb-score-for-the-assessment-of-disease-severity-in-gaucher-disease-possible-impact-of-reporting-experience
#14
Jeffrey K C Lai, Patricia L Robertson, Christine Goh, Jeff Szer
AIM: To evaluate the intraobserver and interobserver agreement for bone marrow burden (BMB) scores for individual examinations and for the change in BMB score over time in the same patient. METHODS: A total of 119 sets of MR images of the lumbar spine and femora from 60 patients with Gaucher disease were included. Each set of MR images was scored using the BMB score independently by two experienced MSK radiologists. One radiologist performed a second read four weeks later...
November 14, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28184012/chromosome-20q-amplification-defines-a-subtype-of-microsatellite-stable-left-sided-colon-cancers-with-wild-type-ras-raf-and-better-overall-survival
#15
Ryan N Ptashkin, Carlos Pagan, Rona Yaeger, Sumit Middha, Jinru Shia, Kevin P O'Rourke, Michael F Berger, Lu Wang, Robert Cimera, Jiajing Wang, David S Klimstra, Leonard Saltz, Marc Ladanyi, Ahmet Zehir, Jaclyn F Hechtman
Here comprehensive analysis was performed on the molecular and clinical features of colorectal carcinoma (CRC) harboring chromosome 20q amplification. Tumor and normal DNA from patients with advanced CRC underwent next generation sequencing (NGS) via MSK-IMPACT and a subset of case samples were subjected to high resolution microarray (Oncoscan). Relationships between genomic copy number and transcript expression were assessed with The Cancer Genome Atlas (TCGA) CRC data. Of the CRC patients sequenced (n=401) with MSK-IMPACT, 148 (37%) had 20q gain, and 30 (7%) had 20q amplification...
February 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28154900/prevalence-of-burnout-among-musculoskeletal-radiologists
#16
Felix S Chew, Michael J Mulcahy, Jack A Porrino, Hyojeong Mulcahy, Annemarie Relyea-Chew
OBJECTIVE: Burnout is a job-related psychological syndrome with three aspects: emotional exhaustion, depersonalization, and perceived lack of personal accomplishment. Burnout is associated with deleterious effects on both workers and their work. When burnout affects physicians, their well-being, longevity, and care of patients are at risk. Recent studies concerning physician burnout treat specialists such as radiologists as one group. We studied burnout in musculoskeletal (MSK) subspecialist radiologists...
February 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28154444/low-back-pain-current-patterns-of-canadian-physiotherapy-service-delivery
#17
Tatiana Orozco, Debbie E Feldman, Barbara Mazer, Gevorg Chilingaryan, Matthew Hunt, Bryn Williams-Jones, Maude Laliberté
Purpose: The aim of this study was to describe the current patterns of service delivery of Canadian physiotherapy (PT) professionals working in adult musculoskeletal (MSK) outpatient practice. Methods: A total of 846 Canadian PT professionals working with an adult MSK outpatient clientele participated in an online survey about how they would treat a patient with low back pain (LBP). After reading an online clinical vignette about a fictional patient with varying insurance status, participants answered questions about how they would treat the patient (e...
2017: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/28153007/musculoskeletal-disorders-as-underlying-cause-of-death-in-58-countries-1986-2011-trend-analysis-of-who-mortality-database
#18
Aliasghar A Kiadaliri, Anthony D Woolf, Martin Englund
BACKGROUND: Due to low mortality rate of musculoskeletal disorders (MSK) less attention has been paid to MSK as underlying cause of death in the general population. The aim was to examine trend in MSK as underlying cause of death in 58 countries across globe during 1986-2011. METHODS: Data on mortality were collected from the WHO mortality database and population data were obtained from the United Nations. Annual sex-specific age-standardized mortality rates (ASMR) were calculated by means of direct standardization using the WHO world standard population...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28151835/predictors-of-the-transition-from-acute-to-persistent-musculoskeletal-pain-in-children-and-adolescents-a-prospective-study
#19
Amy Lewandowski Holley, Anna C Wilson, Tonya M Palermo
Strategies directed at the prevention of disabling pain have been suggested as a public health priority, making early identification of youth at risk for poor outcomes critical. At present, limited information is available to predict which youth presenting with acute pain are at risk for persistence. The aims of this prospective longitudinal study were to identify biopsychosocial factors in the acute period that predict the transition to persistent pain in youth with new-onset musculoskeletal (MSK) pain complaints...
December 22, 2016: Pain
https://www.readbyqxmd.com/read/28137924/dna-damage-response-and-repair-gene-alterations-are-associated-with-improved-survival-in-patients-with-platinum-treated-advanced-urothelial-carcinoma
#20
Min Yuen Teo, Richard Bambury, Emily C Zabor, Emmet J Jordan, Hikmat A Al-Ahmadie, Mariel Boyd, Nancy Bouvier, Stephanie Mullane, Eugene K Cha, Nitin Roper, Irina Ostrovnaya, David M Hyman, Bernard H Bochner, Maria E Arcila, David B Solit, Michael F Berger, Dean F Bajorin, Joaquim Bellmunt, Gopa Iyer, Jonathan E Rosenberg
PURPOSE: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy. EXPERIMENTAL DESIGN: Patients with diagnosis of locally advanced and metastatic urothelial carcinoma treated with platinum-based chemotherapy who had exon sequencing with MSK-IMPACT assay were identified...
January 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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