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https://www.readbyqxmd.com/read/29656758/feasibility-of-endobronchial-ultrasound-transbronchial-needle-aspiration-for-massively-parallel-next-generation-sequencing-in-thoracic-cancer-patients
#1
Simon R Turner, Darren Buonocore, Patrice Desmeules, Natasha Rekhtman, Snjezana Dogan, Oscar Lin, Maria E Arcila, David R Jones, James Huang
INTRODUCTION: Next-generation sequencing (NGS) allows for the identification of a growing number of therapeutic and prognostic molecular targets. However, NGS typically requires greater quantities of DNA than traditional molecular testing does. Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure used to sample central thoracic lesions, but it is not well established whether this technique provides sufficient material for NGS. METHODS: We performed a retrospective review of EBUS-TBNA at our institution (3/1/14-9/28/16)...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29650812/-clinical-implementation-of-precision-medicine
#2
Shuta Tomida, Shinichi Toyooka
In the end of last year, the US Food and Drug Administration has announced the authorization of MSK-IMPACT(TM), clinical test based on multiplex cancer panel profiling for genetic mutations and other alterations in patients' tumors, while in Japan, NCC Oncopanel, domestic multiplex cancer panel, is scheduled to be clinically implemented as advanced medical care B in this coming spring, chasing the state of the art technology for cancer treatment. In this article, we outline a recently published roadmap for precision medicine in Japan, together with our years of experience on cancer diagnosis and treatment based on multiplex cancer panel at Okayama University Hospital and Okadai Biobank...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29615459/genetic-analysis-of-779-advanced-differentiated-and-anaplastic-thyroid-cancers
#3
Nikita Pozdeyev, Laurie Gay, Ethan S Sokol, Ryan J Hartmaier, Kelsi E Deaver, Stephanie N Davis, Jena D French, Pierre Vanden Borre, Daniel V LaBarbera, Aik-Choon Tan, Rebecca E Schweppe, Lauren Fishbein, Jeffrey S Ross, Bryan R Haugen, Daniel W Bowles
PURPOSE: To define the genetic landscape of advanced differentiated and anaplastic thyroid cancer and identify genetic alterations of potential diagnostic, prognostic and therapeutic significance. EXPERIMENTAL DESIGN: The genetic profiles of 583 advanced differentiated and 196 anaplastic thyroid cancers (ATC) generated with targeted next-generation sequencing cancer-associated gene panels MSK-IMPACT and FoundationOne were analyzed. RESULTS: ATC had more genetic alterations per tumor, and pediatric papillary thyroid cancer had fewer genetic alterations per tumor when compared to other thyroid cancer types...
April 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29611556/-helicobacter-hepaticus-polysaccharide-induces-an-anti-inflammatory-response-in-intestinal-macrophages
#4
COMMENT
Camille Danne, Fiona Powrie
A high density of microbes inhabits the intestine, helping with food digestion, vitamin synthesis, xenobiotic detoxification, pathogen resistance and immune system maturation. Crucial for human health, communities of commensal bacteria (collectively termed microbiota) benefit in return from a nutrient-rich environment. Host-microbiota mutualism results from a long-term co-adaptation. At barrier surfaces, immune cells distinguish harmful from commensal bacteria and tolerate non-self organisms at close proximity to the mucosa; gut inhabitants have developed strategies to ensure beneficial conditions in their preferred niche...
March 22, 2018: Microbial Cell
https://www.readbyqxmd.com/read/29610937/paediatric-musculoskeletal-disease-in-kumi-district-uganda-a-cross-sectional-survey
#5
Kristin Alves, Norgrove Penny, Olive Kobusingye, Robert Olupot, Jeffrey N Katz, Coleen S Sabatini
PURPOSE: The purpose of this study is to estimate the burden of musculoskeletal disease among children treated in Kumi District, Uganda, to inform training, capacity-building efforts, and resource allocation. METHODS: We conducted a retrospective cohort study by reviewing the musculoskeletal (MSK) clinic and community outreach logs for children (age < 18 years) seen at Kumi Hospital in Kumi, Uganda, between January 2013 and December 2015. For each patient, we recorded the age, sex, diagnosis, and treatment recommendation...
April 2, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29610121/response-to-erbb3-directed-targeted-therapy-in-nrg1-rearranged-cancers
#6
Alexander Drilon, Romel Somwar, Biju P Mangatt, Henrik Edgren, Patrice Desmeules, Anja Ruusulehto, Roger S Smith, Lukas Delasos, Morana Vojnic, Andrew J Plodkowski, Joshua Sabari, Kenneth Ng, Joseph Montecalvo, Jason Chang, Huichun Tai, William W Lockwood, Victor Martinez, Gregory J Riely, Charles M Rudin, Mark G Kris, Maria E Arcila, Christopher Matheny, Ryma Benayed, Natasha Rekhtman, Marc Ladanyi, Gopinath Ganji
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMAs) of the lung. The oncoprotein binds ERBB3-ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm of ERBB3/ERBB2 inhibition. As proof of concept, a durable response was achieved with anti-ERBB3 monoclonal antibody therapy (GSK2849330) in an exceptional responder with an NRG1-rearranged IMA on a phase 1 trial (NCT01966445). In contrast, response was not achieved with anti-ERBB2 therapy (afatinib) in four NRG1-rearranged IMA patients (including the index patient post-GSK2849330)...
April 2, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29597084/pain-adaptability-in-individuals-with-chronic-musculoskeletal-pain-is-not-associated-with-conditioned-pain-modulation
#7
Dawn Wong Lit Wan, Lars Arendt-Nielsen, Kelun Wang, Charlie Changli Xue, Yanyi Wang, Zhen Zheng
Healthy humans can be divided into the pain adaptive (PA) and the pain non-adaptive (PNA) groups; PA showed a greater decrease in pain rating to a cold pressor test (CPT) than PNA. This study examined if the dichotomy of pain adaptability existed in individuals with chronic musculoskeletal pain (MSK). CPTs at 2°C and 7°C were used to assess the status of pain adaptability in participants with either chronic non-specific low back pain or knee osteoarthritis. The participants' potency of conditioned pain modulation (CPM) and local inhibition were measured...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29577907/possible-role-of-ginsenoside-rb1-in-skin-wound-healing-via-regulating-senescent-skin-dermal-fibroblast
#8
Jingang Hou, Sunchang Kim
Cellular senescence suppresses cancer by inducing irreversible cell growth arrest. Nevertheless, senescent cells is proposed as causal link with aging and aging-related pathologies. The physiological beneficial functions of senescent cells are still of paucity. Here we show that senescent human dermal fibroblast accelerates keratinocytes scratch wound healing and stimulates differentiation of fibroblast. Using oxidative stress (100 μM H2 O2 exposure for 1 h) induction, we successfully triggered fibroblast senescence and developed senescence associated secretory phenotype (SASP)...
March 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29572263/gender-differences-in-the-associations-of-body-mass-index-physical-fitness-and-tobacco-use-with-lower-extremity-musculoskeletal-injuries-among-new-us-army-soldiers
#9
Sheryl A Bedno, D Alan Nelson, Lianne M Kurina, Y Sammy Choi
BACKGROUND: Musculoskeletal (MSK) injuries are a leading cause of morbidity among US Army soldiers, especially among women and the newly enlisted. While extremes of body mass index (BMI), low physical fitness and tobacco use have been identified as risk factors, no prior studies have determined the combined effects of these risk factors or tested for gender differences in the associations. METHODS: We conducted a retrospective cohort study utilising the Stanford Military Data Repository to study all enlisted soldier accessions to the US Army between January 2011 and January 2014, with follow-up through December 2014 (n=238 772)...
March 23, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29566109/adoption-of-total-neoadjuvant-therapy-for-locally-advanced-rectal-cancer
#10
Andrea Cercek, Campbell S D Roxburgh, Paul Strombom, J Joshua Smith, Larissa K F Temple, Garrett M Nash, Jose G Guillem, Philip B Paty, Rona Yaeger, Zsofia K Stadler, Kenneth Seier, Mithat Gonen, Neil H Segal, Diane L Reidy, Anna Varghese, Jinru Shia, Efsevia Vakiani, Abraham J Wu, Christopher H Crane, Marc J Gollub, Julio Garcia-Aguilar, Leonard B Saltz, Martin R Weiser
Importance: Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been developed to optimize delivery of effective systemic therapy aimed at micrometastases. Objective: To compare the traditional approach of preoperative chemoradiation (chemoRT) followed by postoperative adjuvant chemotherapy with the more recent TNT approach for LARC...
March 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29556113/comparing-psychological-burden-of-orthopaedic-diseases-against-medical-conditions-investigation-on-hospital-course-of-hip-knee-and-spine-surgery-patients
#11
Bassel G Diebo, Denis Cherkalin, Cyrus M Jalai, Neil V Shah, Greg W Poorman, George A Beyer, Frank A Segreto, Virginie Lafage, Qais Naziri, Jared M Newman, William P Urban, Thomas J Errico, Frank J Schwab, Carl B Paulino, Peter G Passias
Retrospective review of National Inpatient Sample (2000-2012) revealed that 31.28% of musculoskeletal (MSK) patients were found to have in-hospital psychological burdens (PBs). Adult spinal deformity (ASD), degenerative disc disease (DDD) and lung cancer patients had highest PB-prevalence. MSK patients with PB were more often young, white females with increased Deyo index compared to no-PB patients. Patients who underwent spinal revision procedures had higher PB rates than with primary procedures; a converse trend was observed for total hip/knee arthroplasty...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29554522/manual-method-of-visually-identifying-candidate-signals-for-a-targeted-peptide
#12
Aleksey Filimonov, Arthur Kopylov, Andrey Lisitsa, Alexander Archakov
The purpose of this study is to improve peptide signal identification in groups of extracted ion chromatograms (XICs) obtained with the liquid chromatography-selected reaction monitoring (LC-SRM) technique and a triple quadrupole mass spectrometer (QqQ) operating in one of the supported multiple reaction monitoring (MRM) modes. The imperfection of quadrupole mass analyzers causes ion interference, which impedes the identification of peptide signals as chromatographic peak groups in relevant retention time intervals...
January 31, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29540405/new-episodes-of-musculoskeletal-conditions-among-employed-people-in-norway-sickness-certification-and-return-to-work-a-multiregister-based-cohort-study-from-primary-care
#13
Sturla Gjesdal, Tor Helge Holmaas, Karin Monstad, Øystein Hetlevik
OBJECTIVES: To identify new cases of musculoskeletal (MSK) disorders among employed people presenting in Norwegian primary care in 2012, frequency of sickness certification and length of sick leave. To identify patient-, diagnosis- and GP-related predictors of sickness certification, prolonged sick leave and return to work (RTW). METHODS: An observational multiregister-based cohort study covering all employed persons in Norway(1 176 681 women and 1 330 082 men) based on claims data from all regular GPs merged with individual sociodemographic data from public registers was performed...
March 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29533023/a-score-system-for-complete-cytoreduction-in-selected-recurrent-ovarian-cancer-patients-undergoing-secondary-cytoreductive-surgery-predictors-and-nomogram-based-analyses
#14
Giorgio Bogani, Elena Tagliabue, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Lavinia Mosca, Ilaria Sabatucci, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). METHODS: Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied...
February 23, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29527173/obesity-metabolic-syndrome-and-musculoskeletal-disease-common-inflammatory-pathways-suggest-a-central-role-for-loss-of-muscle-integrity
#15
REVIEW
Kelsey H Collins, Walter Herzog, Graham Z MacDonald, Raylene A Reimer, Jaqueline L Rios, Ian C Smith, Ronald F Zernicke, David A Hart
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically, or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regarding its pathophysiological link to chronic cardiovascular conditions and type 2 diabetes, the musculoskeletal (MSK) complications (i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29508217/quality-of-endoscopy-reports-for-esophageal-cancer-patients-where-do-we-stand
#16
Arianna Barbetta, Shahdabul Faraz, Pari Shah, Hans Gerdes, Meier Hsu, Kay See Tan, Tamar Nobel, Manjit S Bains, Matthew Bott, James M Isbell, David B Sewell, David R Jones, Daniela Molena
BACKGROUNDS AND AIMS: As treatment for esophageal cancer often involves a multidisciplinary approach, the initial endoscopic report is essential for communication between providers. Several guidelines have been established to standardize endoscopic reporting. This study evaluates the compliance of esophagogastroduodenoscopy (EGD) and endoscopic ultrasound (EUS) reporting with the current national guidelines. METHODS: Combining the National Comprehensive Cancer Network and Society of Thoracic Surgeons guidelines, 11 quality indicators (QIs) for EGD and 8 for EUS were identified...
March 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29496399/brain-metastases-in-pancreatic-ductal-adenocarcinoma-assessment-of-molecular-genotype-phenotype-features-an-entity-with-an-increasing-incidence
#17
Emmet J Jordan, Maeve A Lowery, Olca Basturk, Peter J Allen, Kenneth H Yu, Viviane Tabar, Kathryn Beal, Diane L Reidy, Yoshiya Yamada, Yelena Janjigian, Ghassan K Abou-Alfa, Eileen M O'Reilly
PURPOSE: To assess clinical characteristics of patients with metastatic pancreas ductal adenocarcinoma (PDAC) and brain metastases (BM), and to assess somatic and germ-line molecular profiles where performed. PATIENTS AND METHODS: Patients with PDAC and BM between January 1990 and January 2016 were identified. Molecular characteristics of somatic and germ-line testing where performed in the subset of patients who had provided informed consent. Somatic alterations were assessed by either MSK-IMPACT testing (>340 key cancer genes) or Sequenom testing (8-gene panel)...
February 7, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29489411/who-refers-musculoskeletal-extremity-imaging-examinations-to-radiologists
#18
Paul Harkey, Richard Duszak, Soterios Gyftopoulos, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study is to identify the specialty characteristics of providers referring musculoskeletal (MSK) extremity imaging examinations to radiologists, so as to better understand the drivers of MSK imaging utilization and potentially improve the appropriateness of such imaging examinations. MATERIALS AND METHODS: Data on provider referral for MSK extremity imaging services were extracted from the 2014 Medicare Referring Provider Utilization for Procedures public use file, which aggregates data on diagnostic procedures according to referring provider identities and service codes...
April 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29480927/technical-note-scintillation-well-counters-and-particle-counting-digital-autoradiography-devices-can-be-used-to-detect-activities-associated-with-genomic-profiling-adequacy-of-biopsy-specimens-obtained-after-a-low-activity-18-f-fdg-injection
#19
A S Kirov, L Fanchon, D Seiter, C Czmielewski, J Russell, S Dogan, S Carlin, K Pinker-Domenig, E Yorke, C R Schmidtlein, V Boyko, S Fujisawa, K Manova-Todorova, P Zanzonico, L Dauer, J O Deasy, J L Humm, S Solomon
PURPOSE: Genomic profiling of biopsied tissue is the basis for precision cancer therapy. However biopsied materials may not contain sufficient amounts of tumor deoxyribonucleonic acid needed for the analysis. We propose a method to determine the adequacy of specimens for performing genomic profiling by quantifying their metabolic activity. METHODS: We estimated the average density of tumor cells in biopsy specimens needed to successfully perform genomic analysis following the Memorial Sloan Kettering Intregrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) protocol from the minimum amount of deoxyribonucleonic acid needed and the volume of tissue typically used for analysis...
February 26, 2018: Medical Physics
https://www.readbyqxmd.com/read/29472748/efficacy-and-safety-of-oral-diclofenac-sustained-release-versus-transdermal-diclofenac-patch-in-chronic-musculoskeletal-pain-a-randomized-open-label-trial
#20
Viraj Ashok Shinde, Mrunalini Kalikar, Satyajeet Jagtap, Ganesh N Dakhale, Mangesh Bankar, Chaitali S Bajait, Vijay M Motghare, Ashlesha A Pashilkar, Latesh B Raghute, Ajita D Khamkar
Introduction: To compare the efficacy, safety, and tolerability of transdermal patches of diclofenac sodium with oral diclofenac sustained release (SR) in patients of chronic musculoskeletal MSK pain conditions. Materials and Methods: The eligible patients were given either transdermal diclofenac patch or tablet diclofenac SR. Pain was assessed at 2 and 4 weeks using a visual analog scale. Adverse events were recorded. Patients with 18-65 years old of either gender with score of ≥4 on a 11-item numeric rating scale-numeric version of visual analog scale for pain with diagnosis of primary osteoarthritis (OA) of the knee or hand of at least 3 months duration, with independent radiological confirmation of OA or having pain associated with other MSK conditions such as soft-tissue rheumatism, cervical and lumbar back pain, and fibromyalgia, of at least 3 months duration were included in this study...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
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