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https://www.readbyqxmd.com/read/27914711/proteomic-based-research-strategy-identified-laminin-subunit-alpha-2-as-a-potential-urinary-specific-biomarker-for-the-medullary-sponge-kidney-disease
#1
Antonia Fabris, Maurizio Bruschi, Laura Santucci, Giovanni Candiano, Simona Granata, Alessandra Dalla Gassa, Nadia Antonucci, Andrea Petretto, Gian Marco Ghiggeri, Giovanni Gambaro, Antonio Lupo, Gianluigi Zaza
Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identify such we employed a proteomic-based research strategy utilizing urine from 22 patients with MSK and 22 patients affected by idiopathic calcium nephrolithiasis (ICN) as controls. Notably, two patients with ICN presented cysts...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27900289/deducing-a-mechanism-of-all-musculoskeletal-injuries
#2
Geoffrey Verrall, Bronwyn Dolman
BACKGROUND: The mechanism of musculoskeletal (MSK) injuries is not well understood. This research applies principles of elastic motion to the anatomy and movement patterns of MSK structures. From this an insight into the application and timing of forces on MSK structures can be established and the mechanism/s of injury derived. METHODS CURRENT KNOWLEDGE: All MSK structures demonstrate varying degrees of elasticity. Movement occurs primarily as a consequence of Muscle Tendon Unit (MTU) shortening...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27886946/building-multidisciplinary-health-workforce-capacity-to-support-the-implementation-of-integrated-people-centred-models-of-care-for-musculoskeletal-health
#3
REVIEW
M J Chehade, T K Gill, D Kopansky-Giles, L Schuwirth, J Karnon, P McLiesh, J Alleyne, A D Woolf
To address the burden of musculoskeletal (MSK) conditions, a competent health workforce is required to support the implementation of MSK models of care. Funding is required to create employment positions with resources for service delivery and training a fit-for-purpose workforce. Training should be aligned to define "entrustable professional activities", and include collaborative skills appropriate to integrated and people-centred care and supported by shared education resources. Greater emphasis on educating MSK healthcare workers as effective trainers of peers, students and patients is required...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886943/use-of-ehealth-technologies-to-enable-the-implementation-of-musculoskeletal-models-of-care-evidence-and-practice
#4
REVIEW
Helen Slater, Blake F Dear, Mark A Merolli, Linda C Li, Andrew M Briggs
Musculoskeletal (MSK) conditions are the second leading cause of morbidity-related burden of disease globally. EHealth is a potentially critical factor that enables the implementation of accessible, sustainable and more integrated MSK models of care (MoCs). MoCs serve as a vehicle to drive evidence into policy and practice through changes at a health system, clinician and patient level. The use of eHealth to implement MoCs is intuitive, given the capacity to scale technologies to deliver system and economic efficiencies, to contribute to sustainability, to adapt to low-resource settings and to mitigate access and care disparities...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886939/development-and-implementation-of-models-of-care-for-musculoskeletal-conditions-in-middle-income-and-low-income-asian-countries
#5
REVIEW
Keith K Lim, Madelynn Chan, Sandra Navarra, Syed Atiqul Haq, Chak Sing Lau
This chapter discusses the challenges faced in the development and implementation of musculoskeletal (MSK) Models of Care (MoCs) in middle-income and low-income countries in Asia and outlines the components of an effective MoC for MSK conditions. Case studies of four such countries (The Philippines, Malaysia, Bangladesh and Myanmar) are presented, and their unique implementation issues are discussed. The success experienced in one high-income country (Singapore) is also described as a comparison. The Community Oriented Program for Control of Rheumatic Diseases (COPCORD) project and the role of Asia Pacific League of Associations for Rheumatology (APLAR), a professional body supporting MoC initiatives in this region, are also discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886937/models-of-care-for-musculoskeletal-health-moving-towards-meaningful-implementation-and-evaluation-across-conditions-and-care-settings
#6
REVIEW
Andrew M Briggs, Madelynn Chan, Helen Slater
Models of Care (MoCs) are increasingly recognised as a system-level enabler to translate evidence for 'what works' into policy and, ultimately, clinical practice. MoCs provide a platform for a reform agenda in health systems by describing not only what care to deliver but also how to deliver it. Given the enormous burden of disease associated with musculoskeletal (MSK) conditions, system-level (macro) reform is needed to drive downstream improvements in MSK healthcare - at the health service (meso) level and at the clinical interface (micro) level...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27878226/psychometric-properties-of-multidimensional-health-locus-of-control-a-and-general-self-efficacy-scale-in-civil-servants-elsa-brasil-musculoskeletal-study-elsa-brasil-msk
#7
Luciana A C Machado, Rosa W Telles, Luciana Costa-Silva, Sandhi M Barreto
Background: Health-related control and self-efficacy beliefs can be assessed in the general population using Multidimensional Health Locus of Control-A subscales (MHLC-A) and the General Self-Efficacy Scale (GSES), respectively. Objective: To test construct validity, internal consistency, reliability (test-retest) and ceiling and floor effects of Portuguese-Brazil versions of MHLC-A and GSES. Method: Civil servants (N=2901) enrolled in a large Brazilian cohort were included...
June 30, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27875625/clinical-and-genetic-determinants-of-ovarian-metastases-from-colorectal-cancer
#8
Karuna Ganesh, Ronak H Shah, Efsevia Vakiani, Garrett M Nash, Hugh P Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H Segal, Diane L Reidy, Anna Varghese, Andrew S Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F Berger, Leonard Saltz, Zsofia K Stadler
BACKGROUND: Ovarian metastases from colorectal cancer (OM-CRC) often are unresponsive to chemotherapy and are associated with poor survival. To the authors' knowledge, the clinicopathologic and genomic predictors of OM-CRC are poorly characterized and optimal clinical management remains unclear. METHODS: Women with a histopathological diagnosis of OM-CRC who were treated at Memorial Sloan Kettering Cancer Center from 1999 to 2015 were identified. Next-generation somatic mutation profiling (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) was performed on 38 OM-CRC cases, including 21 matched tumor pairs/trios...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27870683/increasing-role-of-image-guided-ablation-in-the-treatment-of-musculoskeletal-tumors
#9
Anil Nicholas Kurup, Matthew R Callstrom
In the last decade, percutaneous treatment of musculoskeletal (MSK) tumors has become more established in routine clinical care while also undergoing a number of advancements. Ablative techniques to palliate painful skeletal metastases have gained wide acceptance, while goals for ablation have evolved to include local control of oligometastases and desmoid tumors. Bone consolidation or augmentation is now frequently used in conjunction with or instead of ablation of skeletal tumors to stabilize pathologic fractures or prevent further morbidity that could result from fractures caused by tumor progression...
November 2016: Cancer Journal
https://www.readbyqxmd.com/read/27866430/assessing-catastrophic-thinking-associated-with-debilitating-mental-health-conditions
#10
Emily Moore, Heather Adams, Tamra Ellis, Pascal Thibault, Michael J L Sullivan
PURPOSE: The present study examined the psychometric properties of the Symptom Catastrophizing Scale (SCS). The SCS items were drawn from the Pain Catastrophizing Scale but were modified to make them better suited to the context of debilitating mental health conditions that are not necessarily associated with pain. The number of items was reduced from 13 to 7, and the response scale was simplified. METHODS: The SCS was administered to individuals diagnosed with Major Depressive Disorder (MDD) (N = 79) or with a chronic musculoskeletal (MSK) condition (N = 88)...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27855319/caring-for-disabled-older-adults-with-musculoskeletal-conditions-a-transactional-model-of-caregiver-burden-coping-strategies-and-depressive-symptoms
#11
Nan Lu, Jinyu Liu, Fei Wang, Vivian W Q Lou
OBJECTIVES: This study investigated the mediating role of coping strategies in the relationship between caregiver burden and depressive symptoms among family caregivers caring for disabled older adults with musculoskeletal (MSK) conditions. METHODS: The cross-sectional data were from a quota sampling of 494 pairs of disabled older adults and their primary family caregivers in Shanghai, China. The disabled older adults had MSK conditions and limitations in activities of daily living...
November 4, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27831746/the-interrelationship-of-common-clinical-movement-screens-establishing-population-specific-norms-in-a-large-cohort-of-military-applicants
#12
Sarah J de la Motte, Timothy C Gribbin, Peter Lisman, Anthony I Beutler, Patricia Deuster
CONTEXT:  Musculoskeletal injuries (MSK-Is) are a leading cause of missed duty time and morbidity in the military. Modifiable risk factors for MSK-Is, such as inadequate core stability, poor movement patterns, and dynamic balance deficits, have not been identified in military applicants on entering service. OBJECTIVE:  To establish normative functional movement data using a series of screens in military applicants entering basic training and explore relationships among several movement tests...
November 10, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27795299/ifn%C3%AE-production-is-regulated-by-p38-mapk-in-macrophages-via-both-msk1-2-and-ttp-dependent-pathways
#13
Victoria A McGuire, Dalya Rosner, Olga Ananieva, Ewan A Ross, Suzanne E Elcombe, Shaista Naqvi, Mirjam M W van den Bosch, Claire E Monk, Tamara Ruiz-Zorrilla Diez, Andrew R Clark, J Simon C Arthur
Autocrine or paracrine signaling by the type I interferon IFNβ is essential for many of the responses of macrophages to pathogen-associated molecular patterns. This feedback loop contributes to pathological responses to infectious agents, and is therefore tightly regulated. We demonstrate here that macrophage expression of IFNβ is negatively regulated by mitogen- and stress-activated kinases (MSK) 1 and 2. Lipopolysaccharide- (LPS-) induced expression of IFNβ was elevated in both MSK1/2 knockout mice and macrophages...
October 17, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27789972/keele-aches-and-pains-study-protocol-validity-acceptability-and-feasibility-of-the-keele-start-msk-tool-for-subgrouping-musculoskeletal-patients-in-primary-care
#14
Paul Campbell, Jonathan C Hill, Joanne Protheroe, Ebenezer K Afolabi, Martyn Lewis, Ruth Beardmore, Elaine M Hay, Christian D Mallen, Bernadette Bartlam, Benjamin Saunders, Danielle A van der Windt, Sue Jowett, Nadine E Foster, Kate M Dunn
Musculoskeletal conditions represent a considerable burden worldwide, and are predominantly managed in primary care. Evidence suggests that many musculoskeletal conditions share similar prognostic factors. Systematically assessing patient's prognosis and matching treatments based on prognostic subgroups (stratified care) has been shown to be both clinically effective and cost-effective. This study (Keele Aches and Pains Study) aims to refine and examine the validity of a brief questionnaire (Keele STarT MSK tool) designed to enable risk stratification of primary care patients with the five most common musculoskeletal pain presentations...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27757719/characterization-of-a-novel-germline-palb2-duplication-in-a-hereditary-breast-and-ovarian-cancer-family
#15
Ciyu Yang, Angela G Arnold, Magan Trottier, Yukio Sonoda, Nadeem R Abu-Rustum, Oliver Zivanovic, Mark E Robson, Zsofia K Stadler, Michael F Walsh, David M Hyman, Kenneth Offit, Liying Zhang
PURPOSE: Mutations in PALB2 have been associated with a predisposition to breast and pancreatic cancers. This study aims to characterize a novel PALB2 exon 13 duplication in a hereditary breast and ovarian cancer family. METHODS: The PALB2 exon 13 duplication in this family was evaluated using Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT™) and confirmed by multiplex ligation-dependent probe amplification (MLPA)...
October 18, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27742026/imaging-of-musculoskeletal-infection
#16
Kevin R Math, Jennifer L Berkowitz, Stephen A Paget, Yoshimi Endo
Diagnostic imaging plays a crucial role in confirming the diagnosis of musculoskeletal (MSK) infection and determining the severity and extent of disease. The clinical diagnosis may be challenging due to the nonspecific presentation of pain and swelling. There are certain features that are pathognomonic for infection. Pre-existing conditions an make diagnosing infection difficult. Prior surgery can create artifacts on advanced imaging modalities such as computed tomography and MRI, obscuring the tissues immediately around the hardware...
November 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27739242/central-pain-processing-in-patients-with-shoulder-pain-a-review-of-the-literature
#17
Suzie Noten, Filip Struyf, Enrique Lluch, Marika D'Hoore, Eveline Van Looveren, Mira Meeus
BACKGROUND: Shoulder pain is a common health problem in which changes in shoulder structure cannot always explain the patient's perceived pain. Central sensitization (CS) might play a role in a subgroup of these patients. METHODS: The literature was systematically reviewed to address the role of CS in patients with shoulder pain. Electronic databases PubMed and Web of Knowledge were searched for relevant studies. RESULTS: Eighteen full-text articles were included, methodological quality was scored, and information was extracted...
October 14, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27723933/animal-models-for-rotator-cuff-repair
#18
Amir Lebaschi, Xiang-Hua Deng, Jianchun Zong, Guang-Ting Cong, Camila B Carballo, Zoe M Album, Christopher Camp, Scott A Rodeo
Rotator cuff (RC) injuries represent a significant source of pain, functional impairment, and morbidity. The large disease burden of RC pathologies necessitates rapid development of research methodologies to treat these conditions. Given their ability to model anatomic, biomechanical, cellular, and molecular aspects of the human RC, animal models have played an indispensable role in reducing injury burden and advancing this field of research for many years. The development of animal models in the musculoskeletal (MSK) research arena is uniquely different from that in other fields in that the similarity of macrostructures and functions is as critical to replicate as cellular and molecular functions...
November 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27717394/musculoskeletal-care-pathways-for-adults-with-hip-and-knee-pain-at-the-interface-between-primary-and-secondary-care-protocol-for-a-systematic-review
#19
Kate Button, Fiona Morgan, Helen Hodgson, Alison L Weightman, Steve Jones
BACKGROUND: Musculoskeletal (MSK) conditions are the most frequently reported chronic conditions and one of the biggest causes of disability in the UK. Given the ageing population and the impact of these problems, the demand for MSK treatment will rise. Despite reduced waiting times, MSK pathways have remained variable and inconsistent and need to be improved to meet patient needs. The aim of this systematic review is to understand the evidence for the effectiveness of current models of service delivery and care pathways for adult hip/knee pain patients accessing secondary care for specialist opinions...
August 1, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27706273/preparticipation-physical-exams-the-rhode-island-perspective-a-call-for-standardization
#20
Peter K Kriz, Ailis Clyne, Sara R Ford
As of 2015, 98% of U.S. states require preparticipation exams (PPE) before participating in scholastic sports. Despite widespread availability of a PPE monograph endorsed by six medical societies, a lack of uniformity exists regarding implementation of the PPE among Rhode Island health care providers (HCPs). Consequently, significant variability exists regarding how comprehensive a history and physical exam screening is conducted for adolescent athletes looking for sports participation clearance. The purpose of this document is to: 1) establish a uniform screening process in Rhode Island for the PPE utilizing a peer-reviewed history and physical exam; 2) familiarize HCPs with the 2010 PPE monograph, with emphasis on the cardiovascular and musculoskeletal (MSK) systems; 3) encourage HCPs to treat the PPE as a separate entity from the annual wellness visit; 4) engage HCPs and sports medicine providers in Rhode Island to improve the quality and process of evaluating adolescent athletes for sports participation...
October 4, 2016: Rhode Island Medical Journal
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