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Alberto Cauli, Dafna D Gladman, Alessandro Mathieu, Ignazio Olivieri, Giovanni Porru, Paul P Tak, Claudia Sardu, Raffaele Scarpa, Antonio Marchesoni, William J Taylor, Carlo Salvarani, Joachim Kalden, Ennio Lubrano, Sueli Carneiro, Matteo Piga, Alberto Floris, Francesca Desiati, John A Flynn, Salvatore D'Angelo, Arno W R van Kuijk, Maria Grazia Catanoso, Francesco Caso, Paolo Contu, Ilona Ujfalussy, Philip S Helliwell, Philip J Mease
OBJECTIVE: Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). METHODS: Sixteen centers from 8 countries enrolled 319 consecutive patients with PsA...
June 15, 2018: Journal of Rheumatology
Bradley L Young, Colin K Cantrell, Joshua C Patt, Brent A Ponce
Background: Accessible, adequate online information is important to fellowship applicants. Program web sites can affect which programs applicants apply to, subsequently altering interview costs incurred by both parties and ultimately impacting rank lists. Web site analyses have been performed for all orthopaedic subspecialties other than those involved in the combined adult reconstruction and musculoskeletal (MSK) oncology fellowship match. Methods: A complete list of active programs was obtained from the official adult reconstruction and MSK oncology society web sites...
June 2018: Arthroplasty Today
Jason Peeler, Hugo Bergen, Alison Bulow
Medical schools have traditionally used a lecture and dissection-based approach for educating students about human anatomy. There is growing interest in the adoption of alternative teaching and learning activities (TLAs) that incorporate the use of cadaveric prosection and computer-based learning into musculoskeletal (MSK) anatomy curricula. The purpose of this investigation was to examine retrospectively how different TLAs influenced student perceptions about learning, and performance on MSK anatomy examinations...
June 7, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Sonica Sondhi, Randhir Kaur, Supreet Kaur, Palki Sahib Kaur
Decolourization of textile effluent is always being a problem of major concern for the safe disposal of effluent water in river stream. Due to intense colour of the effluent water, even after the treatment, disposal of the water in river stream is under strict environmental regulation. Laccase, a natural oxidase, have the miraculous power to decolourize different dyes with or without mediators. However, stability and cost of implementation of the enzyme at industrial conditions make the entire process unfeasible at industrial scale...
June 6, 2018: International Journal of Biological Macromolecules
Fadi M Al Zoubi, Anita Menon, Nancy E Mayo, André E Bussières
BACKGROUND: The objective of this systematic review was to summarize and evaluate evidence about the effectiveness of knowledge translation (KT) interventions to improve the uptake and application of clinical practice guidelines and best practices for a wide range of musculoskeletal (MSK) disorders and health care professionals. METHODS: A search for relevant randomized controlled trials (RCTs) published in English was conducted in MEDLINE (Ovid interface), EMBASE, CINAHL, and CENTRAL (Cochrane library)...
June 8, 2018: BMC Health Services Research
Daniel L Bailey, Melanie A Holden, Nadine E Foster, Jonathan G Quicke, Kirstie L Haywood, Annette Bishop
OBJECTIVE: To establish the meaning of the term 'adherence' (including conceptual and measurement definitions) in the context of therapeutic exercise (TE) for musculoskeletal (MSK) pain. DESIGN: Systematic review using a search strategy including terms for: adherence, TE and MSK pain. Identified studies were independently screened for inclusion by two researchers. Two independent researchers extracted data on: study type; MSK pain population; type of TE used; definitions, parameters, measurement methods and values of adherence...
June 6, 2018: British Journal of Sports Medicine
Ryan N Ptashkin, Diana L Mandelker, Catherine C Coombs, Kelly Bolton, Zarina Yelskaya, David M Hyman, David B Solit, José Baselga, Maria E Arcila, Marc Ladanyi, Liying Zhang, Ross L Levine, Michael F Berger, Ahmet Zehir
Importance: Although clonal hematopoiesis (CH) is well described in aging healthy populations, few studies have addressed the practical clinical implications of these alterations in solid-tumor sequencing. Objective: To identify and quantify CH-related mutations in patients with solid tumors using matched tumor-blood sequencing, and to establish the proportion that would be misattributed to the tumor based on tumor-only sequencing (unmatched analysis). Design, Setting, and Participants: Retrospective analysis of samples from 17 469 patients with solid cancers who underwent prospective clinical sequencing of DNA isolated from tumor tissue and matched peripheral blood using the MSK-IMPACT assay between January 2014 and August 2017...
June 5, 2018: JAMA Oncology
M Attique Khan, Tallha Akram, Muhammad Sharif, Aamir Shahzad, Khursheed Aurangzeb, Musaed Alhussein, Syed Irtaza Haider, Abdualziz Altamrah
BACKGROUND: Melanoma is the deadliest type of skin cancer with highest mortality rate. However, the annihilation in its early stage implies a high survival rate therefore, it demands early diagnosis. The accustomed diagnosis methods are costly and cumbersome due to the involvement of experienced experts as well as the requirements for the highly equipped environment. The recent advancements in computerized solutions for this diagnosis are highly promising with improved accuracy and efficiency...
June 5, 2018: BMC Cancer
M Y Teo, R M Bambury, E C Zabor, E Jordan, H Al-Ahmadie, M E Boyd, N Bouvier, S A Mullane, E K Cha, N Roper, I Ostrovnaya, D M Hyman, B H Bochner, M E Arcila, D B Solit, M F Berger, D F Bajorin, J Bellmunt, G Iyer, J E Rosenberg
PURPOSE: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy. EXPERIMENTAL DESIGN: Patients with diagnosis of locally advanced and metastatic urothelial carcinoma treated with platinum-based chemotherapy who had exon sequencing with the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay were identified...
May 30, 2018: Urologic Oncology
Orna Fennelly, Catherine Blake, Oliver FitzGerald, Roisin Breen, Jennifer Ashton, Aisling Brennan, Aoife Caffrey, François Desmeules, Caitriona Cunningham
BACKGROUND: Many people with musculoskeletal (MSK) disorders wait several months or years for Consultant Doctor appointments, despite often not requiring medical or surgical interventions. To allow earlier patient access to orthopaedic and rheumatology services in Ireland, Advanced Practice Physiotherapists (APPs) were introduced at 16 major acute hospitals. This study performed the first national evaluation of APP triage services. METHOD: Throughout 2014, APPs (n = 22) entered clinical data on a national database...
June 1, 2018: BMC Musculoskeletal Disorders
Maeve A Lowery, Ryan N Ptashkin, Emmet J Jordan, Michael F Berger, Ahmet Zehir, Marinela Capanu, Nancy E Kemeny, Eileen M O'Reilly, Imane El Dika, William R Jarnagin, James J Harding, Michael I D'Angelica, Andrea Cercek, Jaclyn F Hechtman, David B Solit, Nikolaus Schultz, David M Hyman, David S Klimstra, Leonard Saltz, Ghassan K Abou-Alfa
PURPOSE: Various genetic driver aberrations have been identified among distinct anatomic and clinical subtypes of intrahepatic and extrahepatic cholangiocarcinoma, and these molecular alterations may be prognostic biomarkers and/or predictive of drug response. EXPERIMENTAL DESIGN: Tumor samples from patients with cholangiocarcinoma who consented prospectively were analyzed using the MSK-IMPACT platform, a targeted next generation sequencing assay that analyzes all exons and selected introns of 410 cancer-associated genes...
May 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Chenfei Huang, Zhe Cao, Jun Ma, Yi Shen, Yiwen Bu, Ramina Khoshaba, Guiyuan Shi, Dan Huang, Duan-Fang Liao, Haitao Ji, Junfei Jin, Deliang Cao
Aldo-keto reductase 1B10 (AKR1B10) is upregulated in breast cancer and promotes tumor growth and metastasis. However, little is known of the molecular mechanisms of action. Herein we report that AKR1B10 activates lipid second messengers to stimulate cell proliferation. Our data showed that ectopic expression of AKR1B10 in breast cancer cells MCF-7 promoted lipogenesis and enhanced levels of lipid second messengers, including phosphatidylinositol bisphosphate (PIP2), diacylglycerol (DAG) and inositol triphosphate (IP3)...
May 30, 2018: Molecular Carcinogenesis
Abolfazl Doostparast Torshizi, Kai Wang
Next-generation sequencing (NGS) enabled high-throughput analysis of genotype-phenotype relationships on human populations, ushering in a new era of genetics-informed drug development. The year 2017 was remarkable, with the first FDA-approved gene therapy for cancer (Kymriah™) and for inherited diseases (LUXTURNA™), the first multiplex NGS panel for companion diagnostics (MSK-IMPACT™) and the first drug targeting a genetic signature rather than a disease (Keytruda® ). We envision that population-scale NGS with paired electronic health records (EHRs) will become a routine measure in the drug development process for the identification of novel drug targets, and that genetically stratified clinical trials could be widely adopted to improve power in precision-medicine-guided drug development...
May 24, 2018: Drug Discovery Today
Elizabeth Bryant, Shemane Murtagh, Laura Finucane, Carol McCrum, Christopher Mercer, Toby Smith, Guy Canby, David A Rowe, Ann P Moore
BACKGROUND: In response for the need of a freely available, stand-alone, validated outcome measure for use within musculoskeletal (MSK) physiotherapy practice, sensitive enough to measure clinical effectiveness, we developed an MSK patient reported outcome measure. OBJECTIVES: This study examined the validity and reliability of the newly developed Brighton musculoskeletal Patient-Reported Outcome Measure (BmPROM) within physiotherapy outpatient settings. METHODS: Two hundred twenty-four patients attending physiotherapy outpatient departments in South East England with an MSK condition participated in this study...
May 11, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Jagannath Sharma, R Heagerty, S Dalal, B Banerjee, T Booker
BACKGROUND: Musculoskeletal injury (MSKI), a common problem in both military and physically active civilian populations has been suggested to result from both extrinsic and intrinsic factors. OBJECTIVE: This study was to investigate prospectively whether gait biomechanics, aerobic fitness level and smoking status as well as entry military selection test variables can be used to predict MSKI development during recruit training. METHOD: British infantry male recruits (n = 562) were selected for the study...
April 29, 2018: Current Rheumatology Reviews
Geoffrey S Gaunay, Robert G Berkenblit, Christian H Tabib, Jeffrey R Blitstein, Manoj Patel, David M Hoenig
Objective: To expand the diagnostic armamentarium for medullary sponge kidney (MSK), we evaluate the use of high-resolution multidetector computed tomography (MDCT) for MSK diagnosis and compare to the standard intravenous urography (IVU). Despite a significant prevalence amongst stone formers, diagnosis of this well described condition has declined. IVU, the gold standard in MSK diagnosis, has largely been replaced by CT, which has previously been shown unable to demonstrate signs of MSK...
March 2018: Current Urology
Christopher Gaunder, Scot Campbell, Michael Sciortino, Mark Slabaugh
PURPOSE: The purpose of this study is to determine the incidence of anterolateral ligament (ALL) tears on magnetic resonance imaging (MRI) in patients diagnosed with anterior cruciate ligament (ACL) tears. Furthermore, this study sought to determine the inter- and intraobserver reliability in diagnosing an ALL tear. METHODS: The MRI radiologic database at a community military hospital was queried for ACL tears over the period of January 2011 to April 2015. During this time, 181 MRIs were identified as having ACL tears...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Hiten D Patel, Mohit Gupta, Jeffrey J Tosoian, H Ballentine Carter, Alan W Partin, Jonathan I Epstein
INTRODUCTION: Intermediate-risk (IR) prostate cancer is a heterogenous classification with favorable criteria proposed based on men treated with radiation therapy but uncertain application to active surveillance. We quantified the rate of adverse surgical pathology and implications for survival for patients with favorable IR (FIR) compared to low-risk (LR) prostate cancer. MATERIALS AND METHODS: A comparative cohort study of men with prostate cancer (2009-2013) undergoing radical prostatectomy was conducted in the National Cancer Database...
April 16, 2018: Journal of Urology
Iwona Sudoł-Szopińska, Adam Greenspan
No abstract text is available yet for this article.
April 2018: Seminars in Musculoskeletal Radiology
Simon R Turner, Darren Buonocore, Patrice Desmeules, Natasha Rekhtman, Snjezana Dogan, Oscar Lin, Maria E Arcila, David R Jones, James Huang
INTRODUCTION: Next-generation sequencing (NGS) allows for the identification of a growing number of therapeutic and prognostic molecular targets. However, NGS typically requires greater quantities of DNA than traditional molecular testing does. Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure used to sample central thoracic lesions, but it is not well established whether this technique provides sufficient material for NGS. METHODS: We performed a retrospective review of EBUS-TBNA at our institution (3/1/14-9/28/16)...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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