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https://www.readbyqxmd.com/read/29234504/the-effects-of-low-intensity-blood-flow-restricted-exercise-compared-with-conventional-resistance-training-on-the-clinical-outcomes-of-active-uk-military-personnel-following-a-3-week-in-patient-rehabilitation-programme-protocol-for-a-randomized-controlled-feasibility
#1
Peter Ladlow, Russell J Coppack, Shreshth Dharm-Datta, Dean Conway, Edward Sellon, Stephen D Patterson, Alexander N Bennett
Background: A challenge for rehabilitation practitioners lies in designing optimal exercise programmes that facilitate musculoskeletal (MSK) adaptations whilst simultaneously accommodating biological healing and the safe loading of an injured limb. A growing body of evidence supports the use of resistance training at a reduced load in combination with blood flow restriction (BFR) to enhance hypertrophic and strength responses in skeletal muscle. In-patient rehabilitation has a long tradition in the UK Military, however, the efficacy of low intensity (LI) BFR training has not been tested in this rehabilitation setting...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29224702/early-intervention-to-restore-function-and-maintain-healthy-trajectory
#2
REVIEW
Juan Jover, Lydia Abasolo
The health of the global population has undergone rapid transformation. Life expectancy and chronic conditions are increasing, and persons aged 65 years or older have become the fastest growing segment of population. The worldwide picture of disease burden is increasingly defined by disability instead of premature mortality. Population growth, ageing and sedentary lifestyles, particularly in developing countries, will result in a crisis for the population health that requires a multi-system response. The growing awareness of the diseases burden increases the need for accurate measurement and assessment of the burden and measurement of the impact of any public health action...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224691/musculoskeletal-health-conditions-among-older-populations-in-urban-slums-in-sub-saharan-africa
#3
REVIEW
Isabella Aboderin, Agnes Nanyonjo
BACKGROUND: Debate on the burden of musculoskeletal (MSK) conditions in lower and middle income countries is intensifying; yet, little knowledge so far exists on patterns and impacts of such conditions among general or older adult populations in sub-Saharan Africa (SSA). The objectives of this study are to examine the prevalence, potential predictors, and sequelae of MSK among older adults residing in two low resource informal urban settlements or "slums" in Nairobi Kenya. METHODS: Data on older adults aged 60 years and over from two unrelated cross-sectional surveys on the older slum populations are used: a 2006/7 survey on the social, health, and overall well-being of older people (sample N = 831), and a 2016 survey on realities and impacts of long-term care and social protection for older adults (sample n = 1026)...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29214619/real-time-interrater-reliability-of-a-novel-musculoskeletal-readiness-screening-tool
#4
Mark D Thelen, Shane L Koppenhaver, Shanee E Allen, Michael U Bolduc, Riley K Quan, Anne E Sidwell
Military service members receive regular screenings for a variety of health conditions, but a field-expedient and military-specific screening tool that identifies an individual's risk for injury has not yet been identified. The purpose of this study is to describe the conduct of a novel musculoskeletal readiness screening tool (MRST) and evaluate the real-time interrater reliability of the MRST when scored by raters with differing levels of medical experience. MATERIALS/METHODS: This study included a convenience sample of 40 active duty military participants (30 male, 10 female, mean age 29...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29209219/differential-effects-of-inhibitor-combinations-on-lysophosphatidic-acid-mediated-chemokine-secretion-in-unprimed-and-tumor-necrosis-factor-%C3%AE-primed-synovial-fibroblasts
#5
Weili Hui, Chenqi Zhao, Sylvain G Bourgoin
Lysophosphatidic acid (LPA) is a pleiotropic bioactive lysophospholipid involved in inflammatory mediator synthesis. Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. The study was undertaken to investigate how LPA activates MSKs and how signaling crosstalk between TNFα and LPA contributes to the super-production of cytokines/chemokines. RAFLS pretreated or not with TNFα were stimulated with LPA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29207995/physicians-using-spinal-manipulative-treatment-in-the-netherlands-a-description-of-their-characteristics-and-their-patients
#6
Wouter Schuller, Raymond W J G Ostelo, Daphne C Rohrich, Adri T Apeldoorn, Henrica C W de Vet
BACKGROUND: Various health care professionals apply Spinal Manipulative Treatment (SMT) in daily practice. While the characteristics of chiropractors and manual therapists and the characteristics of their patient populations are well described, there is little research about physicians who use SMT techniques. A distinct group of physicians in The Netherlands has been trained in musculoskeletal (MSK) medicine, which includes the use of SMT. Our objective was to describe the characteristics of these physicians and their patient population...
December 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29175827/poor-overall-quality-of-clinical-practice-guidelines-for-musculoskeletal-pain-a-systematic-review
#7
REVIEW
Ivan Lin, Louise K Wiles, Robert Waller, Roger Goucke, Yusuf Nagree, Michael Gibberd, Leon Straker, Christopher G Maher, Peter P B O'Sullivan
OBJECTIVES: Undertake a systematic critical appraisal of contemporary clinical practice guidelines (CPGs) for common musculoskeletal (MSK) pain conditions: spinal (lumbar, thoracic and cervical), hip/knee (including osteoarthritis) and shoulder. DESIGN: Systematic review of CPGs (PROSPERO number: CRD42016051653).Included CPGs were written in English, developed within the last 5 years, focused on adults and described development processes. Excluded CPGs were for: traumatic MSK pain, single modalities (eg, surgery), traditional healing/medicine, specific disease processes (eg, inflammatory arthropathies) or those that required payment...
November 25, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29169299/the-changing-case-mix-of-hip-fractures-in-scotland-evidence-from-the-scottish-hip-fracture-audit
#8
Stephen D Hannah, K B Ferguson, R Smith, J Hutchison, G Holt
Until discontinued in 2008, the Scottish Hip Fracture Audit collected and reported on data relating to the quality of care of hip fracture patients in Scotland. In 2013, the audit was recommenced under the umbrella of the MSK Audit group, which audits high volume orthopaedic pathways across Scotland. Our aim is to report on the changes in the demographics of hip fracture patients in Scotland between 2003 and 2013. There was an increase in the proportion of male patients from 2003 to 2013 (22.4% to 29.5%; p < 0...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/29146616/therapeutic-potential-of-afatinib-for-cancers-with-erbb2-her2-transmembrane-domain-mutations-g660d-and-v659e
#9
Hiromasa Yamamoto, Shinichi Toyooka, Takashi Ninomiya, Shigemi Matsumoto, Masashi Kanai, Shuta Tomida, Katsuyuki Kiura, Manabu Muto, Ken Suzawa, Patrice Desmeules, Mark G Kris, Bob T Li, Marc Ladanyi
We previously reported on a family with hereditary lung cancer, in which a germline mutation in the transmembrane domain (G660D) of avian erythroblastic leukemia viral oncogene homolog 2 (erb-b2 receptor tyrosine kinase 2) (ERBB2; human epidermal growth factor receptor 2 [HER2]) seemed to be responsible for the cancer predisposition. Although few data are available on treatment, anti-ERBB2 therapeutic agents may be effective for ERBB2-mutant cancers. The familial lung cancer patient in one of the authors' institutes developed bone metastasis with enlarging lung tumors and was treated with the ERBB2 inhibitor afatinib...
November 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29129347/international-society-for-the-study-of-vascular-anomalies-classification-of-soft-tissue-vascular-anomalies-survey-based-assessment-of-musculoskeletal-radiologists-use-in-clinical-practice
#10
Shivani Ahlawat, Laura M Fayad, Daniel J Durand, Kate Puttgen, Aylin Tekes
AIM: There is controversy regarding the diagnosis and classification of vascular anomalies (VA). As torso and extremities are the second most common body part for presentation of VAs, musculoskeletal (MSK) radiologists play a central role in VA classification. The purpose of this study was to evaluate the awareness and clinical use of the International Society for the Study of Vascular Anomalies (ISSVA) classification by MSK radiologists. MATERIALS AND METHODS: A Web-based survey was designed and electronically sent to Society of Skeletal Radiology (SSR) members, with 3 questions on demographics and 7 questions on ISSVA classification use and knowledge...
October 16, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29127119/rasa1-and-nf1-are-preferentially-co-mutated-and-define-a-distinct-genetic-subset-of-smokingassociated-non-small-cell-lung-carcinomas-sensitive-to-mek-inhibition
#11
Takuo Hayashi, Patrice Desmeules, Roger S Smith, Alexander Drilon, Romel Somwar, Marc Ladanyi
PURPOSE: Ras-GTPase activating proteins (RasGAPs), notably NF1 and RASA1, mediate negative control of the RAS/MAPK pathway. We evaluated clinical and molecular characteristics of NSCLC with RASA1 mutations in comparison with NF1-mutated cases. EXPERIMENTAL DESIGN: Large genomic datasets of NSCLC [MSK-IMPACT™ dataset at MSKCC (n=2004), TCGA combined lung cancer dataset (n=1144)] were analyzed to define concurrent mutations and clinical features of RASA1-mutated NSCLCs...
November 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29113426/activating-mutation-of-pdgfrb-gene-in-a-rare-cardiac-undifferentiated-intimal-sarcoma-of-the-left-atrium-a-case-report
#12
Xiaoling Fu, Weixin Niu, Ji Li, Amber J Kiliti, Hikmat A Al-Ahmadie, Gopa Iyer, Sizhi Paul Gao, Qi Li
Cardiac sarcoma is a rare malignant tumor with undefined genetic mutations and no targeted therapy. Here in one rare case of undifferentiated cardiac intimal sarcoma (IS), a next-generation sequencing based assay, MSK-IMPACT (Memorial Sloan Kettering - Integrated Mutation Profiling of Actionable Cancer Targets), identified a somatic, activating mutation in PDGFRB, along with amplification of PDGFRA. This E472D mutation of PDGFRB was discovered for the first time in IS. These findings suggest that concurrent aberrant PDGFRA and PDGFRB signaling may be a diagnostic biomarker and molecular therapeutic target of IS of the heart...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102478/reliability-validity-and-minimal-detectable-change-of-the-push-off-test-scores-in-assessing-upper-extremity-weight-bearing-ability
#13
Saurabh P Mehta, Hannah R George, Christian A Goering, Danielle R Shafer, Alan Koester, Steven Novotny
STUDY DESIGN: Clinical measurement study. INTRODUCTION: The push-off test (POT) was recently conceived and found to be reliable and valid for assessing weight bearing through injured wrist or elbow. However, further research with larger sample can lend credence to the preliminary findings supporting the use of the POT. PURPOSE OF THE STUDY: This study examined the interrater reliability, construct validity, and measurement error for the POT in patients with wrist conditions...
November 1, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29101775/outpatient-satisfaction-with-osteopathic-manipulative-treatment-in-a-hospital-center-a-survey
#14
Marco Tramontano, Alex Martino Cinnera, Marco Petracca, Angela Gaeta, Federica Tamburella, Maurice Audouard, Carlo Caltagirone
Context • Although osteopathy is not yet certified as a health profession in Italy, many people choose osteopathic manipulative treatment (OMT) for pain relief. Nevertheless, no study evaluating patients' degree of satisfaction after OMT and the perceived quality of the treatment has occurred in Italy. Objectives • The study intended to assess outpatients' satisfaction with OMT carried out at a hospital. Design • The research team conducted a survey from January 2015 to January 2016 using 3 questionnaires...
October 28, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29077271/prevalence-of-rheumatic-musculoskeletal-symptoms-in-rural-and-urban-areas-a-cross-sectional-study-in-northern-india
#15
Ragini Alok, Ragini Srivastava, Puneet Kumar, Siddharth K Das, Girdhar G Agarwal, Pooja Dhaon
OBJECTIVES: To study the prevalence of rheumatic musculoskeletal symptoms in rural and urban areas of Lucknow. METHOD: The survey was carried out in a cluster of rural (n = 5118) and urban (n = 5053) communities of Lucknow through a door-to-door survey. Demographic data were collected and subjects with musculoskeletal pain (MSK pain) were identified. A Hindi adapted version of the Community Oriented Program for the Control of Rheumatic Diseases questionnaire was used...
October 27, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29075524/diagnostic-errors-in-musculoskeletal-ultrasound-imaging-and-how-to-avoid-them
#16
REVIEW
Małgorzata Serafin-Król, Artur Maliborski
The article reviews the major challenges related to the principles of the correct technique of musculoskeletal ultrasound (MSK US). All the crucial aspects of correct MSK soft tissue diagnosis have been discussed, including equipment settings, use of recent image software innovations and ultrasound standoff pads, and correct transducer positioning. The importance of the fundamental principles of MSK US, facilitating good quality image and limiting the occurrence of artifacts, has been highlighted. The most common artifacts of the musculoskeletal system have been described, including those that diagnostically helpful, such as the presence of echo enhancement deep to a fluid-filled structure, or an acoustic shadow behind a calcification...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29069300/rosc-pred-web-service-for-rodent-organ-specific-carcinogenicity-prediction
#17
Alexey Lagunin, Anastasia Rudik, Dmitry Druzhilovsky, Dmitry Filimonov, Vladimir Poroikov
Motivation: Identification of rodent carcinogens is an important task in risk assessment of chemicals. SAR methods were proposed to reduce the number of animal experiments. Most of these methods ignore information about organ-specificity of tumorigenesis. Our study was aimed at the creation of classification models and a freely available online service for prediction of rodent carcinogens considering the species (rats, mice), sex, and tissue-specificity from structural formula of compounds...
October 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29068672/effects-of-black-raspberry-extract-and-berry-compounds-on-repair-of-dna-damage-and-mutagenesis-induced-by-chemical-and-physical-agents-in-human-oral-leukoplakia-and-rat-oral-fibroblasts
#18
Joseph Guttenplan, Kun-Ming Chen, Yuan-Wan Sun, Braulio Lajara, Nora Ae Shalaby, Wieslawa Kosinska, Gabrielle Benitez, Krishne Gowda, Shantu Amin, Gary David Stoner, Karam El-Bayoumy
Black raspberries (BRB) have been shown to inhibit carcinogenesis in a number of systems, with most studies focusing on progression. Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo[a,l]pyrene dihydrodiol (DBP-diol) induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Here we extend this work to protection by BE, against DNA adduct formation induced by dibenzo[a,l]pyrene (DBP) in a human oral leukoplakia cell line (MSK) and to second carcinogen, UV light...
October 25, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29050173/-effects-of-percutaneous-nephrolithotomy-in-the-treatment-of-medullary-sponge-kidney-with-calculi
#19
Y Hong, Q Q Xu, X B Huang, Z J Zhu, H Y Ye, F S Zhang, Q Y Yang, L Z An, T Xu
Objective: To evaluate the effects of percutaneous nephrolithotomy (PNL) in the treatment of medullary sponge kidney with calculi. Methods: A total of 77 patients (91 renal units) of medullary sponge kidney with calculi (MSK group) and 77 patients (77 renal units) with common kidney stone (control group) received PNL at Department of Urology in Peking University People's Hospital from September 2006 to February 2016 were analyzed retrospectively. The MSK group included 33 males and 44 females with a mean age of (42...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29021235/oral-analgesics-utilization-for-children-with-musculoskeletal-injury-ouch-trial-an-rct
#20
RANDOMIZED CONTROLLED TRIAL
Sylvie Le May, Samina Ali, Amy C Plint, Benoit Mâsse, Gina Neto, Marie-Christine Auclair, Amy L Drendel, Ariane Ballard, Christelle Khadra, Edith Villeneuve, Stefan Parent, Patrick J McGrath, Grégoire Leclair, Serge Gouin
BACKGROUND: Musculoskeletal injuries (MSK-Is) are a common and painful condition among children that remains poorly treated in the emergency department (ED). We aimed to test the efficacy of a combination of an anti-inflammatory drug with an opioid for pain management of MSK-I in children presenting to the ED. METHODS: In this randomized, double-blinded, placebo-controlled trial, we enrolled children between 6 and 17 years presenting to the ED with an MSK-I and a pain score >29 mm on the visual analog scale (VAS)...
November 2017: Pediatrics
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