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Kevin R Math, Jennifer L Berkowitz, Stephen A Paget, Yoshimi Endo
Diagnostic imaging plays a crucial role in confirming the diagnosis of musculoskeletal (MSK) infection and determining the severity and extent of disease. The clinical diagnosis may be challenging due to the nonspecific presentation of pain and swelling. There are certain features that are pathognomonic for infection. Pre-existing conditions an make diagnosing infection difficult. Prior surgery can create artifacts on advanced imaging modalities such as computed tomography and MRI, obscuring the tissues immediately around the hardware...
November 2016: Rheumatic Diseases Clinics of North America
Suzie Noten, Filip Struyf, Enrique Lluch, Marika D'Hoore, Eveline Van Looveren, Mira Meeus
BACKGROUND: Shoulder pain is a common health problem in which changes in shoulder structure cannot always explain the patient's perceived pain. Central sensitization (CS) might play a role in a subgroup of these patients. METHODS: The literature was systematically reviewed to address the role of CS in patients with shoulder pain. Electronic databases PubMed and Web of Knowledge were searched for relevant studies. RESULTS: Eighteen full-text articles were included, methodological quality was scored, and information was extracted...
October 14, 2016: Pain Practice: the Official Journal of World Institute of Pain
Amir Lebaschi, Xiang-Hua Deng, Jianchun Zong, Guang-Ting Cong, Camila B Carballo, Zoe M Album, Christopher Camp, Scott A Rodeo
Rotator cuff (RC) injuries represent a significant source of pain, functional impairment, and morbidity. The large disease burden of RC pathologies necessitates rapid development of research methodologies to treat these conditions. Given their ability to model anatomic, biomechanical, cellular, and molecular aspects of the human RC, animal models have played an indispensable role in reducing injury burden and advancing this field of research for many years. The development of animal models in the musculoskeletal (MSK) research arena is uniquely different from that in other fields in that the similarity of macrostructures and functions is as critical to replicate as cellular and molecular functions...
October 10, 2016: Annals of the New York Academy of Sciences
Kate Button, Fiona Morgan, Helen Hodgson, Alison L Weightman, Steve Jones
BACKGROUND: Musculoskeletal (MSK) conditions are the most frequently reported chronic conditions and one of the biggest causes of disability in the UK. Given the ageing population and the impact of these problems, the demand for MSK treatment will rise. Despite reduced waiting times, MSK pathways have remained variable and inconsistent and need to be improved to meet patient needs. The aim of this systematic review is to understand the evidence for the effectiveness of current models of service delivery and care pathways for adult hip/knee pain patients accessing secondary care for specialist opinions...
August 1, 2016: Systematic Reviews
Peter K Kriz, Ailis Clyne, Sara R Ford
As of 2015, 98% of U.S. states require preparticipation exams (PPE) before participating in scholastic sports. Despite widespread availability of a PPE monograph endorsed by six medical societies, a lack of uniformity exists regarding implementation of the PPE among Rhode Island health care providers (HCPs). Consequently, significant variability exists regarding how comprehensive a history and physical exam screening is conducted for adolescent athletes looking for sports participation clearance. The purpose of this document is to: 1) establish a uniform screening process in Rhode Island for the PPE utilizing a peer-reviewed history and physical exam; 2) familiarize HCPs with the 2010 PPE monograph, with emphasis on the cardiovascular and musculoskeletal (MSK) systems; 3) encourage HCPs to treat the PPE as a separate entity from the annual wellness visit; 4) engage HCPs and sports medicine providers in Rhode Island to improve the quality and process of evaluating adolescent athletes for sports participation...
October 4, 2016: Rhode Island Medical Journal
Ilya Igolnikov, Matthew J Santiago, Kathryn T Gollotto
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Dana L Keester, Carolyn M Sommerich
Tattoo artists are an understudied worker population with respect to investigation of work-related musculoskeletal (MSK) discomfort and associated risk factors. Results from one discomfort survey has been published; no analysis of worker biomechanics has been published. As such, a study was conducted to begin exposure assessment of tattoo artists to work factors that could result in MSK discomfort. Consistent with the prior survey, the current study showed an elevated prevalence of MSK discomfort. Twelve month discomfort prevalence exceeded 50% in the neck, shoulders, hands/wrists, and upper and lower back (range: 53-94%)...
January 2017: Applied Ergonomics
Laetitia Borsu, Julie Intrieri, Linta Thampi, Helena Yu, Gregory Riely, Khedoudja Nafa, Raghu Chandramohan, Marc Ladanyi, Maria E Arcila
Although next-generation sequencing (NGS) is a robust technology for comprehensive assessment of EGFR mutant lung adenocarcinomas (LADs) with acquired resistance to tyrosine kinase inhibitors, it may not provide sufficiently rapid and sensitive detection of the EGFR T790M mutation, the most clinically relevant resistance biomarker. Here, we describe a digital PCR (dPCR) assay for rapid T790M detection on aliquots of NGS libraries prepared for comprehensive profiling, fully maximizing broad genomic analysis on limited samples...
September 12, 2016: Journal of Molecular Diagnostics: JMD
M A Shahin, M I Sultan, M J Alam, A Saeed, A K Azad, M R Choudhury
Cystic tuberculosis of the bone is a rare form of tuberculosis (TB). The condition presents like Juvenile idiopathic arthritis (JIA) of children. In children, the lesions symmetrically involve the peripheral skeleton, which are less sclerotic than adults. A case report is presented here where the patient presented with i) the extensive involvement of bones with cystic lesion, ii) Hand & feet involvement with multiple bony exostosis iii) Synovial swelling of multiple joints and 4) fever for 6 months. Swelling of the joints was disproportionately greater than pain...
July 2016: Mymensingh Medical Journal: MMJ
Elizabeth Candy, Sam Haworth-Booth, Mark Knight-Davis
OBJECTIVE: The present service evaluation aimed to assess patients' experience of the musculoskeletal interface (MSKI) team, evaluate the outcomes of referrals to secondary care and determine if patients returned to secondary musculoskeletal (MSK) care following discharge from the MSKI team. METHODS: Excel spreadsheets were designed for data capture. The survey was undertaken in June 2012. Patients were invited to complete and return the questionnaire. Data were collated and reported...
September 2016: Musculoskeletal Care
Michael G Fox, Laura W Bancroft
Peer-reviewed abstracts presented at the 2016 Society of Skeletal Radiology (SSR) Annual Meeting were reviewed following oral presentation. Topics felt to be of potential interest to musculoskeletal (MSK) investigators and practicing clinicians are highlighted in this compilation and analysis of the meeting. New concepts regarding MSK imaging and intervention, MSK protocols and techniques, radiology education and quality improvement are included. ePoster highlights are also presented.
November 2016: Skeletal Radiology
David M Walton, Dan Krebs, Dianna Moulden, Peter Wade, Lenerdene Levesque, James Elliott, Joy C MacDermid
Study Design Observational cohort. Background Outcomes for acute musculoskeletal injuries are currently suboptimal, with an estimated 10% to 50% of injured individuals reporting persistent problems. An early risk-targeted intervention may hold value for improving outcomes. Objectives To describe the development and preliminary concurrent and longitudinal validation of the Traumatic Injuries Distress Scale (TIDS), a new tool intended to provide the magnitude and nature of risk for persistent problems following acute musculoskeletal injuries...
October 2016: Journal of Orthopaedic and Sports Physical Therapy
Woo-Seok Lee, Ji-Sun Shin, Dae Sik Jang, Kyung-Tae Lee
Cnidilide, an alkyl phthalide isolated from the rhizome of Cnidium officinale, has been reported to possess antispasmodic and sedative effects. However, the anti-inflammatory capacity and molecular mechanism of cnidilide have not been studied to date. In the present study, we investigated the inhibitory effects of cnidilide on LPS-induced pro-inflammatory mediators and the underlying molecular mechanisms in RAW 264.7 macrophages. Our results indicated that cnidilide potently inhibits inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression at the protein and mRNA levels and their promoter activities, causing attendant decreases in the production of nitric oxide (NO) and prostaglandin E2 (PGE2)...
August 31, 2016: International Immunopharmacology
Paolo Ria, Antonia Fabris, Alessandra Dalla Gassa, Gianluigi Zaza, Antonio Lupo, Giovanni Gambaro
Medullary sponge kidney (MSK) is a congenital renal disorder. Its association with several developmental abnormalities in other organs hints at the likelihood of some shared step(s) in the embryogenesis of the kidney and other organs. It has been suggested that the REarranged during Transfection (RET) proto-oncogene and the Glial cell line-Derived Neurotrophic Factor (GDNF) gene are defective in patients with MSK, and both RET and GDNF are known to have a role in the development of the central nervous system, heart, and craniofacial skeleton...
August 29, 2016: Urolithiasis
Charles R Hazle, Matthew Lee
The practice of manual therapy (MT) is often difficult when providing care for large patients and for practitioners small in stature or with other physical limitations. Many MT techniques can be modified using simple principles to require less exertion, permitting consistency with standards of practice even in the presence of physical challenges. Commonly used MT techniques are herein described and demonstrated with alternative preparatory and movement methods, which can also be adopted for use in other techniques...
July 2016: Journal of Manual & Manipulative Therapy
Susan Armijo-Olivo, Linda J Woodhouse, Ivan A Steenstra, Douglas P Gross
OBJECTIVES: To determine whether the Disabilities of the Arm, Shoulder, and Hand (DASH) tool added to the predictive ability of established prognostic factors, including patient demographic and clinical outcomes, to predict return to work (RTW) in injured workers with musculoskeletal (MSK) disorders of the upper extremity. METHODS: A retrospective cohort study using a population-based database from the Workers' Compensation Board of Alberta (WCB-Alberta) that focused on claimants with upper extremity injuries was used...
August 24, 2016: Occupational and Environmental Medicine
Clair M Jacobs, Beth J Guildford, Warren Travers, Megan Davies, Lance M McCracken
This study aimed to investigate the impact of a brief psychologically informed physiotherapy training (PIPT) course on physiotherapists' attitudes and beliefs towards working with people with chronic pain. Specifically, the training aimed to help the participants better recognise the role of psychosocial factors in chronic pain and to better target the key processes of the psychological flexibility (PF) model in their treatment interactions. A total of 26 physiotherapists working in an outpatient musculoskeletal (MSK) department participated in the 7-hour training session...
February 2016: British Journal of Pain
Mohammad M Alzahrani, Saad M Alqahtani, Michael Tanzer, Reggie C Hamdy
INTRODUCTION: Forceful and repetitive maneuvers constitute the majority of pediatric orthopedic surgical tasks, thus subjecting surgeons to the risk of musculoskeletal (MSK) injuries during their years in practice. The aim of this study was to assess the prevalence, characteristics and impact of MSK disorders among pediatric orthopedic surgeons. METHODS: A modified version of the physical discomfort survey was sent to surgeons who were members of the Pediatric Orthopedic Society of North America (POSNA) via e-mail...
October 2016: Journal of Children's Orthopaedics
Helen O'Leary, Keith M Smart, Niamh A Moloney, Catherine M Doody
BACKGROUND: Research suggests that peripheral and central nervous system sensitization can contribute to the overall pain experience in peripheral musculoskeletal (MSK) conditions. It is unclear, however, whether sensitization of the nervous system results in poorer outcomes following the treatment. This systematic review investigated whether nervous system sensitization in peripheral MSK conditions predicts poorer clinical outcomes in response to a surgical or conservative intervention...
August 19, 2016: Pain Practice: the Official Journal of World Institute of Pain
Anna Huguet, Michelle E Tougas, Jill Hayden, Patrick J McGrath, Jennifer N Stinson, Christine T Chambers
A variety of factors may be involved in the development and course of musculoskeletal (MSK) pain. We undertook a systematic review with meta-analysis to synthesize and evaluate the quality of evidence about childhood and adolescent factors associated with onset and persistence of MSK pain, and its related disability.Studies were identified from searches of electronic databases (PubMed, EMBASE, PsycINFO, CINAHL, and Web of Science), references of included studies, and the Pediatric Pain mail list. Two independent reviewers assessed study inclusion, completed data extraction and evaluated the quality of evidence using a modified GRADE framework...
August 10, 2016: Pain
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