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https://www.readbyqxmd.com/read/28823067/combined-classical-spindle-cell-pleomorphic-lipoma-spectrum-imaging-and-clinical-data
#1
Yara Younan, Anthony Martinez, Nickolas Reimer, Mark Edgar, Felix Gonzalez, Monica Umpierrez, Ty Subhawong, Adam D Singer
OBJECTIVES: Compile the largest study to date on the imaging and clinical features of the classic spindle cell/pleomorphic lipoma spectrum and suggest this diagnosis be included in the differential for benign and malignant macroscopic fat-containing soft tissue masses regardless of the mass location or patient demographics. MATERIALS AND METHODS: An institutional search was performed to identify all available classic-type spindle cell/pleomorphic lipomas with available demographic and imaging data...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28814909/increasing-medical-student-exposure-to-musculoskeletal-medicine-the-initial-impact-of-the-orthopaedic-surgery-and-sports-medicine-interest-group
#2
Dayne T Mickelson, Philip K Louie, Kenneth R Gundle, Alex W Farnand, Douglas P Hanel
PURPOSE: To investigate the impact of the Orthopaedic Surgery and Sports Medicine Interest Group (OSSMIG) on medical student interest and confidence in core musculoskeletal (MSK) concepts through supplemental education and experiences at a single tertiary, academic institution. METHODS: Medical student OSSMIG members at various levels of training were anonymously surveyed at the beginning and end of the 2014-2015 academic year. RESULTS: Eighteen (N=18) medical student interest group members completed the survey...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28814015/postoperative-healing-patterns-in-elbow-using-electromyography-towards-the-development-of-a-wearable-mechatronic-elbow-brace
#3
Raneem Haddara, Yue Zhou, Shrikant Chinchalkar, Ana Luisa Trejos
Musculoskeletal (MSK) conditions are the most common cause of severe long-term pain and physical disability. Current postoperative treatment for patients requires them to follow a long-term physiotherapy program customized for each specific case; however, this process can be complex, time-consuming and without the right therapy it may end up being ineffective. A possible solution involves the development of wearable mechatronic elbow braces that use electromyography (EMG) to identify patient intent. However, EMG characteristics change based on the health of the individual and therefore require further investigation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28800763/causes-trends-and-severity-of-musculoskeletal-injuries-in-ghana
#4
Eric Lawer Torgbenu, Emmanuel K Nakua, Henry Kyei, Eric Badu, Maxwell Peprah Opoku
BACKGROUND: Musculoskeletal [MSK] injuries are common causes of long-term pain and physical disability which affect many people worldwide. The economic and social impacts on the individual, society and national health systems are enormous making a matter of public health concern. Therefore, this study examined the causes and extent of MSK injuries in a referral hospital in Ghana. METHODS: A prospective study design with consecutive sampling method was used to recruit patients admitted at Trauma Unit as well as those receiving orthopaedic reviews at St...
August 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28800005/the-effects-of-british-army-footwear-on-ground-reaction-force-and-temporal-parameters-of-british-army-foot-drill
#5
Alex J Rawcliffe, Scott M Graham, Richard J Simpson, Gavin L Moir, Russell Jj Martindale, Stelios G Psycharakis, Chris Connaboy
High rates of occupational training-related lower-limb musculoskeletal [MSK] overuse injuries are reported for British Army recruits during basic training. Foot-drill is a repetitive impact loading occupational activity and involves striking the ground violently with an extended-knee [straight-leg] landing. Foot-drill produces vertical ground reaction forces [vGRF] equal to and/or greater than those reported for high-level plyometric exercises/activities. Shock absorbing footwear aid in the attenuation of the magnitude of vGRF, resulting in a reduced risk of lower-limb MSK overuse injury when running...
August 9, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28796127/a-systematic-review-of-the-association-between-physical-fitness-and-musculoskeletal-injury-risk-part-2-muscular-endurance-and-muscular-strength
#6
Sarah J de la Motte, Timothy C Gribbin, Peter Lisman, Kaitlin Murphy, Patricia A Deuster
This is a systematic review and evaluation of the current evidence on the association between muscular endurance (ME) and/or muscular strength (MS) and musculoskeletal injury (MSK-I) risk in military and civilian populations. MEDLINE, EBSCO, EMBASE, and the Defense Technical Information Center were searched for original studies published from 1970 through 2015 that examined associations between physical fitness (ME and MS) and MSK-I in military or civilian populations. Methodological quality and strength of the evidence were determined following criteria adapted from previously published systematic reviews...
August 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28756444/engaging-consumers-with-musculoskeletal-conditions-in-health-research-a-user-centred-perspective
#7
Patrick Cheong-Iao Pang, Ornella Clavisi, Shanton Chang
Consumers are frequently involved in different kinds of health research, such as clinical trials, focus groups, and surveys. As pointed out by different studies, recruiting and involving consumers to participate in academic research can be challenging. While different research and guidelines are provided to instruct researchers to recruit participants ethically, they seldom consider the needs and expectations of consumers. In this research, we interviewed 23 consumers with musculoskeletal conditions in Australia, to understand their needs and motivations for participating in research from a user-centred perspective...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28755330/a-critical-appraisal-of-the-quality-of-adult-musculoskeletal-ultrasound-guidelines-using-the-agree-ii-tool-an-euroaim-initiative
#8
Carmelo Messina, Bianca Bignotti, Alberto Tagliafico, Davide Orlandi, Angelo Corazza, Francesco Sardanelli, Luca Maria Sconfienza
OBJECTIVES: Our aim was to evaluate the quality of published guidelines on musculoskeletal ultrasound (MSK-US) for adults. METHODS: Between June and July 2016, we conducted an online search for MSK-US guidelines, which were evaluated by four independent readers blinded to each other using the AGREE II tool. A fifth independent reviewer calculated scores per each domain and agreement between reviewers' scores using the intraclass correlation coefficient (ICC). RESULTS: Five guidelines were included in this appraisal...
July 28, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28750903/computing-eye-gaze-metrics-for-the-automatic-assessment-of-radiographer-performance-during-x-ray-image-interpretation
#9
Laura McLaughlin, Raymond Bond, Ciara Hughes, Jonathan McConnell, Sonyia McFadden
AIM: To investigate image interpretation performance by diagnostic radiography students, diagnostic radiographers and reporting radiographers by computing eye gaze metrics using eye tracking technology. METHODS: Three groups of participants were studied during their interpretation of 8 digital radiographic images including the axial and appendicular skeleton, and chest (prevalence of normal images was 12.5%). A total of 464 image interpretations were collected. Participants consisted of 21 radiography students, 19 qualified radiographers and 18 qualified reporting radiographers who were further qualified to report on the musculoskeletal (MSK) system...
September 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28729156/multivariate-pattern-analysis-utilizing-structural-or-functional-mri-in-individuals-with-musculoskeletal-pain-and-healthy-controls-a-systematic-review
#10
REVIEW
Ashley Smith, Marina López-Solà, Katie McMahon, Ashley Pedler, Michele Sterling
OBJECTIVE: The purpose of this systematic review is to systematically review the evidence relating to findings generated by multivariate pattern analysis (MVPA) following structural or functional magnetic resonance imaging (fMRI) to determine if this analysis is able to: a) Discriminate between individuals with musculoskeletal pain and healthy controls, b) Predict pain perception in healthy individuals stimulated with a noxious stimulus compared to those stimulated with a non-noxious stimulus...
June 15, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28720423/undergraduate-clinical-teaching-in-orthopedic-surgery-a-randomized-control-trial-comparing-the-effect-of-case-based-teaching-and-bedside-teaching-on-musculoskeletal-osce-performance
#11
Martin Kelly, Iain Feeley, Fiona Boland, John M O'Byrne
INTRODUCTION: Musculoskeletal (MSK) complaints are the second most common reason for a hospital outpatient appointment in the US, and account for 19.5% of general practice consultations. Previous studies have shown that passive teaching in medical school does not imbue students with an adequate degree of confidence in MSK evaluation. The aim of this study was to conduct a randomized control trial to compare the effect of the gold standard small group tutorial of bedside teaching against case-based teaching (CBT) in relation to orthopedic surgery in medical students...
July 15, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28719467/pan-trk-immunohistochemistry-is-an-efficient-and-reliable-screen-for-the-detection-of-ntrk-fusions
#12
Jaclyn F Hechtman, Ryma Benayed, David M Hyman, Alexander Drilon, Ahmet Zehir, Denise Frosina, Maria E Arcila, Snjezana Dogan, David S Klimstra, Marc Ladanyi, Achim A Jungbluth
Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain tumors. Here, we explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-generation sequencing assay. Transcription of novel NTRK rearrangements into potentially functional fusion transcripts was assessed via Archer Dx fusion assay. Pan-Trk IHC testing with mAb EPR17341 was performed on all NTRK rearranged cases and 20 cases negative for NTRK fusions on Archer...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28707535/anatomical-and-mr-correlative-study-of-the-proximal-sciatic-nerve-vasculature
#13
Neal Larkman, Guillaume Lefebvre, Thibault Jacques, Anne Cotten, Xavier Demondion, Anne Cotten
AIMS: The aim of our study is to demonstrate that increased T2 signal on MRI could be due to intraneural vessels in asymptomatic individuals, and may therefore be a normal finding. METHODS: An initial anatomic cadaveric study was undertaken to gain a better understanding of the vascular supply of the proximal sciatic nerve. Secondly, a retrospective study of MR imaging of patients without sciatic symptoms was performed to assess the prevalence of intraneural vessels, defined as hyperintensity on at least 3 consecutive slices on both T2 and Gadolinium enhanced T1 weighted imaging, visible on routine MSK pelvic imaging...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28695161/retinoblastoma-making-a-difference-together
#14
EDITORIAL
Mary Elizabeth Davis
Mary Elizabeth is an Oncology Clinical Nurse Specialist from Memorial Sloan-Kettering Cancer Center in New York City, New York. She graduated from University of Delaware in 1985, with a Bachelor's degree in nursing and followed in 1989, with a Masters of Nursing from Columbia University specializing in oncology. Mary Elizabeth works as a Clinical Nurse Specialist in Memorial Sloan Kettering's ambulatory medical oncology consultative services. Her role includes modeling professional practice to the nurses of the services for which she has responsibility including mentoring and precepting nurses who are new to a practice, coordinating and evaluating their clinical experiences, and overseeing their development in the oncology nursing specialty and the ambulatory clinical practice role...
July 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28687168/evidence-based-anatomical-review-areas-derived-from-systematic-analysis-of-cases-from-a-radiological-departmental-discrepancy-meeting
#15
S C Chin, J R Weir-McCall, P M Yeap, R D White, M J Budak, G Duncan, T B Oliver, I A Zealley
AIM: To produce short checklists of specific anatomical review sites for different regions of the body based on the frequency of radiological errors reviewed at radiology discrepancy meetings, thereby creating "evidence-based" review areas for radiology reporting. MATERIALS AND METHODS: A single centre discrepancy database was retrospectively reviewed from a 5-year period. All errors were classified by type, modality, body system, and specific anatomical location...
July 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28681474/probing-the-menasemiquinone-binding-mode-to-nitrate-reductase-a-by-selective-2h-15n-labelling-hyscore-spectroscopy-and-dft-modeling
#16
Maryam Seif Eddine, Frédéric Biaso, Rodrigo Arias-Cartin, Eric Pilet, Julia Rendon, Sevdalina Lyubenova, Farida Seduk, Bruno Guigliarelli, Axel Magalon, Stephane Grimaldi
In vivo specific isotope labelling at the residue or substituent level is used to probe menasemiquinone (MSK) binding to the quinol oxidation site of respiratory nitrate reductase A (NarGHI) from E. coli. 15N selective labelling of His15Nδ or Lys15Nξ in combination with Hyperfine sublevel correlation, (HYSCORE) spectroscopy unambiguously identified His15N as direct hydrogen bond donor to the radical. In contrast, an essentially anisotropic coupling to Lys15Nξ consistent with a through space magnetic interaction was resolved...
July 5, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28660673/patient-reported-outcome-measures-in-advanced-musculoskeletal-physiotherapy-practice-a-systematic-review
#17
Orna Fennelly, Catherine Blake, François Desmeules, Diarmuid Stokes, Caitriona Cunningham
OBJECTIVE: Advanced practice physiotherapists (APPs), also known as extended scope physiotherapists, provide a new model of service delivery for musculoskeletal (MSK) disorders. Research to date has largely focused on health service efficiencies, with less emphasis on patient outcomes. The present systematic review aimed to identify the patient-reported outcome measures (PROMs) being utilized by APPs. METHOD: A wide search strategy was employed, including the PubMed, Embase, CINAHL, CENTRAL and PEDro databases, to identify studies relating to PROMs utilized by APPs in MSK healthcare settings...
June 29, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28623421/comparison-of-dual-energy-ct-ultrasound-and-surface-measurement-for-assessing-tophus-dissolution-during-rapid-urate-debulking
#18
Dodji V Modjinou, Svetlana Krasnokutsky, Soterios Gyftopoulos, Virginia C Pike, Elaine Karis, Robert T Keenan, Kristen Lee, Daria B Crittenden, Jonathan Samuels, Michael H Pillinger
Tophaceous gout is painful and impairs quality of life. The optimal modality for assessing tophus resolution in response to urate-lowering treatment remains poorly defined. Using pegloticase as a model system for resolving tophi, we compared multiple imaging and physical diagnostic strategies for assessing tophus resolution. A 32-year-old subject with chronic refractory tophaceous gout was enrolled and received 6 months of pegloticase treatment. Measurements of tophi using vernier calipers (monthly), photographs and musculoskeletal ultrasound (MSK-US; every 3 months), and dual-energy CT (DECT) were compared...
June 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28591657/agc-kinases-mechanisms-of-regulation-%C3%A2-and-innovative-drug-development
#19
REVIEW
Alejandro E Leroux, Jörg O Schulze, Ricardo M Biondi
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, and YANK, while two other families, Aurora and PLK, are the most closely related to the group. Eight of these families are physiologically activated downstream of growth factor signalling, while other AGC kinases are downstream effectors of a wide range of signals. The different AGC kinase families share aspects of their mechanisms of inhibition and activation...
June 4, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28584132/transposon-mutagenesis-identifies-chromatin-modifiers-cooperating-with-ras-in-thyroid-tumorigenesis-and-detects-atxn7-as-a-cancer-gene
#20
Cristina Montero-Conde, Luis J Leandro-Garcia, Xu Chen, Gisele Oler, Sergio Ruiz-Llorente, Mabel Ryder, Iñigo Landa, Francisco Sanchez-Vega, Konnor La, Ronald A Ghossein, Dean F Bajorin, Jeffrey A Knauf, Jesse D Riordan, Adam J Dupuy, James A Fagin
Oncogenic RAS mutations are present in 15-30% of thyroid carcinomas. Endogenous expression of mutant Ras is insufficient to initiate thyroid tumorigenesis in murine models, indicating that additional genetic alterations are required. We used Sleeping Beauty (SB) transposon mutagenesis to identify events that cooperate with Hras(G12V) in thyroid tumor development. Random genomic integration of SB transposons primarily generated loss-of-function events that significantly increased thyroid tumor penetrance in Tpo-Cre/homozygous FR-Hras(G12V) mice...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
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