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https://www.readbyqxmd.com/read/27817055/hypoalbuminemia-a-risk-factor-for-acute-kidney-injury-development-and-progression-to-chronic-kidney-disease-in-critically-ill-patients
#1
Min Shao, Shengyu Wang, Praveen Kolumam Parameswaran
PURPOSE: The increased likelihood of poor outcomes in critically ill patients with hypoalbuminemia is well recognized. However, hypoalbuminemia remains poorly defined as an independent predictor of acute kidney injury (AKI) and stage 4 chronic kidney diseases (CKD4). The aim of this study was to assess the role of hypoalbuminemia as an independent risk factor for AKI and CKD4 in critically ill patients. DESIGN: A retrospective cohort study. SETTING: General intensive care unit (ICU) at Anhui Provincial Hospital, PR China...
November 5, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27767356/etiology-clinical-profile-and-short-term-outcome-of-acute-kidney-injury-in-children-at-a-tertiary-care-pediatric-nephrology-center-in-pakistan
#2
Vina Tresa, Afshan Yaseen, Ali Asghar Lanewala, Seema Hashmi, Sabeeta Khatri, Irshad Ali, Muhammed Mubarak
BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term outcome...
October 21, 2016: Renal Failure
https://www.readbyqxmd.com/read/27698480/mode-of-renal-replacement-therapy-determines-endotoxemia-and-neutrophil-dysfunction-in-chronic-kidney-disease
#3
Sandra Lemesch, Werner Ribitsch, Gernot Schilcher, Walter Spindelböck, Hildegard Hafner-Gießauf, Gunther Marsche, Lisa Pasterk, Doris Payerl, Bianca Schmerböck, Monika Tawdrous, Alexander R Rosenkranz, Philipp Stiegler, Gerd Kager, Seth Hallström, Karl Oettl, Katharina Eberhard, Angela Horvath, Bettina Leber, Vanessa Stadlbauer
Bacterial infection and sepsis are common complications of chronic kidney disease (CKD). A vicious cycle of increased gut permeability, endotoxemia, inadequate activation of the innate immune system and resulting innate immune dysfunction is hypothesized. We assessed endotoxemia, neutrophil function and its relation to oxidative stress, inflammation and gut permeability in patients with CKD grade 3-5 without renal replacement therapy (CKD group, n = 57), patients with CKD stage 5 undergoing haemodialysis (HD, n = 32) or peritoneal dialysis (PD, n = 28) and patients after kidney transplantation (KT, n = 67) in a cross-sectional observational study...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27684854/a-nationwide-survey-of-clinical-characteristics-management-and-outcomes-of-acute-kidney-injury-aki-patients-with-and-without-preexisting-chronic-kidney-disease-have-different-prognoses
#4
Heng-Chih Pan, Pei-Chen Wu, Vin-Cent Wu, Ya-Fei Yang, Tao-Min Huang, Chih-Chung Shiao, Te-Chuan Chen, Der-Cherng Tarng, Jui-Hsiang Lin, Wei-Shun Yang, Chiao-Yin Sun, Chan-Yu Lin, Tzong-Shinn Chu, Mai-Szu Wu, Kwan-Dun Wu, Yung-Chang Chen, Chiu-Ching Huang
Acute kidney injury (AKI) is a common complication in hospitalized patients. The International Society of Nephrology implemented the "0 by 25" initiative aimed at preventing deaths from treatable AKI worldwide by 2025 and conducted a global snapshot survey in 2014. We joined in the project and conducted this study to compare the epidemiology, risk factors, and prognosis between patients with pure AKI and those with acute-on-chronic kidney disease (ACKD). In this study, we prospectively collected demographic parameters and data on clinical characteristics, baseline comorbidities, management, and outcomes of 201 AKI patients in 18 hospitals in Taiwan from September 2014 to November 2014...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27603387/risk-factors-influencing-the-outcome-of-peptic-ulcer-bleeding-in-chronic-kidney-disease-after-initial-endoscopic-hemostasis-a-nationwide-cohort-study
#5
Chih-Ming Liang, Chien-Ning Hsu, Wei-Chen Tai, Shih-Cheng Yang, Cheng-Kun Wu, Chih-Wei Shih, Ming-Kun Ku, Lan-Ting Yuan, Jiunn-Wei Wang, Kuo-Lun Tseng, Wei-Chih Sun, Tsung-Hsing Hung, Seng-Howe Nguang, Pin-I Hsu, Deng-Chyang Wu, Seng-Kee Chuah
Patients with chronic kidney disease (CKD) who had peptic ulcer bleeding (PUB) may have more adverse outcomes. This population-based cohort study aimed to identify risk factors that may influence the outcomes of patients with CKD and PUB after initial endoscopic hemostasis. Data from 1997 to 2008 were extracted from the National Health Insurance Research Database in Taiwan. We included a cohort dataset of 1 million randomly selected individuals and a dataset of patients with CKD who were alive in 2008. A total of 18,646 patients with PUB were screened, and 1229 patients admitted for PUB after endoscopic hemostasis were recruited...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27512298/changing-picture-of-acute-kidney-injury-in-pregnancy-study-of-259-cases-over-a-period-of-33-years
#6
J Prakash, P Pant, S Prakash, M Sivasankar, R Vohra, P K Doley, L K Pandey, U Singh
The incidence of acute kidney injury (AKI) in pregnancy is declining in developing countries but still remains a major cause of maternal and fetal morbidity and mortality. The aim of the study was to analyze the changing trends in pregnancy related AKI (PR-AKI) over a period of thirty-three years. Clinical characteristics of PR-AKI with respect to incidence, etiology and fetal and maternal outcomes were compared in three study periods, namely 1982-1991,1992-2002 and 2003-2014. The incidence of PR-AKI decreased to 10...
July 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27153924/i%C3%AE%C2%BAb-kinase-inhibitor-attenuates-sepsis-induced-cardiac-dysfunction-in-ckd
#7
Jianmin Chen, Julius E Kieswich, Fausto Chiazza, Amie J Moyes, Thomas Gobbetti, Gareth S D Purvis, Daniela C F Salvatori, Nimesh S A Patel, Mauro Perretti, Adrian J Hobbs, Massimo Collino, Muhammad M Yaqoob, Christoph Thiemermann
Patients with CKD requiring dialysis have a higher risk of sepsis and a 100-fold higher mortality rate than the general population with sepsis. The severity of cardiac dysfunction predicts mortality in patients with sepsis. Here, we investigated the effect of preexisting CKD on cardiac function in mice with sepsis and whether inhibition of IκB kinase (IKK) reduces the cardiac dysfunction in CKD sepsis. Male C57BL/6 mice underwent 5/6 nephrectomy, and 8 weeks later, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture (CLP)...
May 6, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27113688/critical-care-updates-for-the-nephrologist-2016
#8
REVIEW
Xosé L Pérez, Kathleen D Liu
With improvements in supportive care, mortality from sepsis and the acute respiratory distress syndrome has declined over the past 20 years. However, mortality associated with these conditions is still high. We will review the latest clinical trial findings in these fields, along with implications for the nephrologist. Very recently, there have been significant changes with regard to the management of anterior ischemic strokes; given the high rate of cerebrovascular disease in patients with CKD or ESRD, we will review those studies here...
May 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/27011788/role-of-kidney-injury-in-sepsis
#9
REVIEW
Kent Doi
Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant associations of AKI and CKD with poor outcomes of high mortality and medical costs. Although many basic studies have clarified the possible mechanisms of sepsis and septic AKI, translation of the obtained findings to clinical settings has not been successful to date. No specific drug against human sepsis or AKI is currently available...
2016: Journal of Intensive Care
https://www.readbyqxmd.com/read/27007127/unilateral-renal-ischemia-reperfusion-as-a-robust-model-for-acute-to-chronic-kidney-injury-in-mice
#10
Nathalie Le Clef, Anja Verhulst, Patrick C D'Haese, Benjamin A Vervaet
Acute kidney injury (AKI) is an underestimated, yet important risk factor for development of chronic kidney disease (CKD). Even after initial total recovery of renal function, some patients develop progressive and persistent deterioration of renal function and these patients are more likely to progress to end-stage renal disease (ESRD). Animal models are indispensable for unravelling the mechanisms underlying this progression towards CKD and ESRD and for the development of new therapeutic strategies in its prevention or treatment...
2016: PloS One
https://www.readbyqxmd.com/read/26918334/urinary-biomarkers-indicative-of-apoptosis-and-acute-kidney-injury-in-the-critically-ill
#11
MULTICENTER STUDY
Suvi T Vaara, Päivi Lakkisto, Katariina Immonen, Ilkka Tikkanen, Tero Ala-Kokko, Ville Pettilä
BACKGROUND: Apoptosis is a key mechanism involved in ischemic acute kidney injury (AKI), but its role in septic AKI is controversial. Biomarkers indicative of apoptosis could potentially detect developing AKI prior to its clinical diagnosis. METHODS: As a part of the multicenter, observational FINNAKI study, we performed a pilot study among critically ill patients who developed AKI (n = 30) matched to critically ill patients without AKI (n = 30). We explored the urine and plasma levels of cytokeratin-18 neoepitope M30 (CK-18 M30), cell-free DNA, and heat shock protein 70 (HSP70) at intensive care unit (ICU) admission and 24h thereafter, before the clinical diagnosis of AKI defined by the Kidney Disease: Improving Global Outcomes -creatinine and urine output criteria...
2016: PloS One
https://www.readbyqxmd.com/read/26865166/does-the-development-of-chronic-kidney-disease-and-acute-kidney-injury-affect-the-prognosis-after-living-donor-liver-transplantation
#12
Yusuke Inoue, Akihiko Soyama, Mitsuhisa Takatsuki, Masaaki Hidaka, Ayaka Kinoshita, Koji Natsuda, Zhassulan Baimakhanov, Tota Kugiyama, Tomohiko Adachi, Amane Kitasato, Tamotsu Kuroki, Susumu Eguchi
BACKGROUND AND AIMS: Chronic kidney disease (CKD) and acute kidney injury (AKI) have been discussed as complications following living donor liver transplantation (LDLT). The aim of this study was to clarify the relationships among CKD, AKI, and the prognosis after LDLT. METHODS: This study included 118 patients who underwent LDLT in our department. A low eGFR (<60 mL/min/1.73 m(2) ) was regarded to indicate CKD. AKI 1 and AKI 2 were characterized by an increase in the serum creatinine level of 0...
May 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26858715/macrophage-migration-inhibitory-factor-in-clinical-kidney-disease
#13
REVIEW
Annette Bruchfeld, Mårten Wendt, Edmund J Miller
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine implicated in acute and chronic inflammatory conditions, including sepsis, autoimmune disease, atherogenesis, plaque instability, and pulmonary arterial hypertension. MIF in plasma and urine is significantly elevated in patients with acute kidney injury (AKI) and elevated MIF in serum is associated with markers of oxidative stress, endothelial dysfunction, arterial stiffness, and markers of myocardial damage in chronic kidney disease (CKD)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26845211/-candida-peritonitis-and-sepsis-due-to-acinetobacter-baumannii-in-peritoneal-dialysis-an-association-with-prognosis-not-always-unfavourable
#14
Francesco Rapisarda, Roberta Aliotta, Barbara Pocorobba, Grazia Portale, Silvia Ferrario, Luca Zanoli, Pasquale Fatuzzo
Fungal infections have a high incidence in patients receiving peritoneal dialysis. (1)
Peritoneal dialysis is often complicated by peritonitis which has only minimally mycotic etiology, but nonetheless it is associated with 15-45% mortality (8).
 The opportunistic pathogens such as Candida can cause infection in immunocompromised conditions. Even the Acinetobacter tends to infect immunocompromised individuals and it has the same risk factors for infection as Candida: immunosuppression, malignancy, HIV positivity and all the other conditions of immunosuppression, central venous catheterization, mechanical ventilation and prolonged antibiotic therapy...
November 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26632678/value-of-neutrophil-counts-in-predicting-surgery-related-acute-kidney-injury-and-the-interaction-of-these-counts-with-diabetes-in-chronic-kidney-disease-patients-with-hypertension-a-cohort-study
#15
Wei Huang, Xing Liu, Xin-Yao Liu, Yao Lu, Ying Li, Ya-Ping Zhang, Ze-Min Kuang, Dongsheng Cao, Alex F Chen, Hong Yuan
As a component of routine blood cell analyses, the quantity of neutrophils present is a proven predictor of morbidity and mortality in several clinical settings. However, whether episodes of acute kidney injury (AKI) are associated with higher neutrophil counts in vulnerable groups, such as chronic kidney disease (CKD) patients with hypertension, are unknown. This study was conducted to investigate the relationship between neutrophil counts and the incidence of surgery-related AKI in CKD patients with hypertension...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26557553/analysis-of-vascular-access-in-haemodialysis-patients-single-center-experience
#16
R Hemachandar
BACKGROUND: Vascular access is the key in successful management of chronic haemodialysis (HD) patients. Though native arteriovenous fistula (AVF) is considered the access of choice, many patients in our country initiate haemodialysis through central venous catheter (CVC). There is paucity of data on vascular access in haemodialysis patients from southern India. AIM: Aim of the present study was to review our experience of vascular access in Haemodialysis patients (both central venous catheters and arteriovenous fistula) and to assess its success rate and common complications...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26421100/the-clinical-pattern-of-renal-diseases-in-the-nephrology-in-patient-unit-of-the-yaounde-general-hospital-in-cameroon-a-five-year-audit
#17
Francois Folefack Kaze, Forbin Elias Ekokobe, Marie Patrice Halle, Hermine Fouda, Alain Patrick Menanga, Gloria Ashuntantang
INTRODUCTION: Kidney diseases are a growing worldwide problem and one of the major public health threats. We analyzed the spectrum of kidney diseases seen over a five-year period in the nephrology in-patient unit of the Yaounde general hospital. METHODS: This was a retrospective analysis of 225 medical records of patients admitted from January 2005 to December 2009 in the unit with a discharge diagnosis of kidney and urinary tract diseases. The first hospitalization was considered for patients admitted several times for the same disease...
2015: Pan African Medical Journal
https://www.readbyqxmd.com/read/26392784/urinary-tract-infection-caused-by-chromobacterium-violaceum
#18
Narayan Dutt Pant, Manisha Sharma
Chromobacterium violaceum, a proteobacterium, is a facultative anaerobe, which is generally present as the normal flora of water and soil in tropical and subtropical regions. The infection due to Chromobacterium violaceum is rare but mostly fatal. It is responsible for causing fatal cases of septicemia, visceral abscesses, skin and soft tissue infections, meningitis, diarrhea, and rarely urinary tract infection. The bacteria has high propensity to spread causing sepsis. Delayed proper treatment due to limited awareness related to the C...
2015: International Journal of General Medicine
https://www.readbyqxmd.com/read/26375111/sep-9-the-cardiac-dysfunction-caused-by-sepsis-in-animals-with-chronic-kidney-disease-is-attenuated-by-inhibiting-i%C3%AE%C2%BAb-kinase
#19
J Chen, J Kieswich, F Chiazza, T Gobbetti, N S A Patel, M Perretti, M Collino, M M Yaqoob, C Thiemermann
INTRODUCTION: Patients with chronic kidney disease (CKD) requiring dialysis have a higher risk of sepsis and a 100-fold higher mortality. The severity of cardiac dysfunction predicts mortality among septic patients. Here we investigated the roles of pre-existing CKD on the cardiac outcome in mice with sepsis, and whether inhibition of IκB kinase (IKK) reduces the cardiac dysfunction in these animals. METHODS: Male C57BL/6 mice were subjected to 5/6th nephrectomy (SNX) for 8 weeks, and were further subjected to either low dose LPS (2 mg/kg) or cecum ligation and puncture (CLP) (fluid and antibiotics given at 6 h and 18 h)...
October 2015: Shock
https://www.readbyqxmd.com/read/26375091/inf-ir-11-the-late-inhibition-of-inhibitor-of-ikb-kinase-attenuates-acute-kidney-injury-and-the-subsequent-development-of-fibrosis-in-a-rat-model-of-ischaemia-reperfusion-injury
#20
F Johnson, N Patel, M Collino, E Bennetti, C Thiemermann
INTRODUCTION: Sepsis is the most common cause of acute kidney injury (AKI), and AKI has now been described as a major risk factor for chronic kidney disease (CKD). Post-inflammatory renal scarring from the activation of nuclear factor-κB (NF-κB) due to AKI may be an important contributor to CKD development. NF-κB is a diverse family of transcription factors activated by inhibitor of κB kinase (IKK). METHODS: Male Wistar rats underwent a right-hand nephrectomy and unilateral renal ischaemia for 30 minutes or sham operation (no ischemia) (n = 8)...
October 2015: Shock
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