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https://www.readbyqxmd.com/read/28818849/egfr-and-the-risk-of-community-acquired-infections
#1
Hong Xu, Alessandro Gasparini, Junichi Ishigami, Khaled Mzayen, Guobin Su, Peter Barany, Johan Ärnlöv, Bengt Lindholm, Carl Gustaf Elinder, Kunihiro Matsushita, Juan Jesús Carrero
BACKGROUND AND OBJECTIVES: Community-acquired infections are common, contributing to adverse outcomes and increased health care costs. We hypothesized that, with lower eGFR, the incidence of community-acquired infections increases, whereas the pattern of site-specific infections varies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 1,139,470 health care users (mean age =52±18 years old, 53% women) from the Stockholm CREAtinine Measurements Project, we quantified the associations of eGFR with the risk of infections, overall and major types, over 12 months...
August 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28814273/add-on-neurological-benefits-of-antiviral-therapy-in-hcv-patients-with-chronic-kidney-disease-a-nationwide-cohort-study
#2
Ming-Shyan Lin, Tien-Hsing Chen, Wey-Yil Lin, Chi-Hung Liu, Yung-Yu Hsieh, Wen-Nan Chiu, Chih-Hsiang Chang, Mei-Yen Chen, Chang-Min Chung, Yu-Sheng Lin
BACKGROUND: Hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) have rarely been studied because they rarely accept interferon-based therapy (IBT) and have been difficult to follow up. We investigated long-term outcomes of IBT on the population. METHODS: This population-based cohort study used the Taiwan National Health Insurance Research Database as its data source. HCV patients diagnosed with CKD between Jan. 1, 2003, and Dec. 31, 2013, were selected...
August 16, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28795012/chronic-kidney-disease-and-sports-participation-by-children-and-adolescents
#3
REVIEW
Vimal Master Sankar Raj, Dilip R Patel, Lakshmi Ramachandran
Individuals suffering from chronic kidney disease (CKD) deal with major morbidity and mortality including poor exercise tolerance. A variety of factors including anemia, poor muscle mass, cardiovascular changes and limited physical activity contribute to exercise intolerance. Studies suggest that early initiation of aerobic and resistance training improves the muscle function, ability to tolerate exercise and quality of life in CKD patients. A thorough medical examination and exercise testing are recommended before initiating an exercise regimen in individuals with CKD...
July 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28781372/uromodulin-from-physiology-to-rare-and-complex-kidney-disorders
#4
REVIEW
Olivier Devuyst, Eric Olinger, Luca Rampoldi
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect against urinary tract infection and kidney stones, and have roles in kidney injury and innate immunity. Interest in uromodulin was boosted by genetic studies that reported involvement of the UMOD gene, which encodes uromodulin, in a spectrum of rare and common kidney diseases...
September 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28771472/micrornas-in-the-mir-17-and-mir-15-families-are-downregulated-in-chronic-kidney-disease-with-hypertension
#5
Priyanka Nandakumar, Adrienne Tin, Megan L Grove, Jianzhong Ma, Eric Boerwinkle, Josef Coresh, Aravinda Chakravarti
BACKGROUND: In older adults (aged 70-74 years), African-Americans have 4-fold higher risk of developing hypertension-attributed end-stage renal disease (ESRD) than European-Americans. A hypothesized mechanism linking hypertension and progressive chronic kidney disease (CKD) is the innate immune response and inflammation. Persons with CKD are also more susceptible to infection. Gene expression in peripheral blood can provide a view of the innate immune activation profile. We aimed to identify differentially expressed genes, microRNAs, and pathways in peripheral blood between cases with CKD and high blood pressure under hypertension treatment versus controls without CKD and with controlled blood pressure in African Americans...
2017: PloS One
https://www.readbyqxmd.com/read/28761770/extended-peritoneal-dialysis-and-renal-recovery-in-hiv-infected-patients-with-prolonged-aki-a-report-of-2-cases
#6
Donlawat Saengpanit, Pongpratch Puapatanakul, Piyaporn Towannang, Talerngsak Kanjanabuch
Peritoneal dialysis (PD) has recently been established as a treatment option for renal replacement therapy (RRT) in patients with acute kidney injury (AKI). Its efficacy in providing fluid and small solute removal has also been demonstrated in clinical trials and is equivalent to hemodialysis (HD). However, effect of RRT modality on renal recovery after AKI remains a controversy. Moreover, the setting of human immunodeficiency virus- (HIV-) infected patients with AKI requiring RRT makes the decision on RRT initiation and modality selection more complicated...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28748890/prevalence-of-hepatitis-b-core-antibodies-with-negative-hepatitis-b-surface-antigen-in-dialysis-and-chronic-kidney-disease-patients
#7
Nauman Tarif, Muhammad Mohsin Riaz, Omer Sabir, Rizwan Akhter, Kashif Rafique, Nabiha Rizvi
Occult hepatitis B infection (OBI) is a potential cause of infection transmission in patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We carried out a study to assess the prevalence of OBI in CKD Stage II-V or requiring renal replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital, Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124 were dialysis dependent and 64 had acute or CKD Stage II-V...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28745686/-effects-of-keto-amino-acids-and-a-low-protein-diet-on-the-nutritional-status-of-patients-with-stages-3b-4-chronic-kidney-disease
#8
S Yu Milovanova, Yu S Milovanov, M V Taranova, I A Dobrosmyslov
AIM: To evaluate the efficacy of keto/amino acids in maintaining protein balance and preventing mineral metabolic disturbances and the development of uremic hyperparathyroidism in the long-term use of a low-protein diet (LPD) in patients with Stages 3B-4 chronic kidney disease (CKD). SUBJECTS AND METHODS: Ninety patients with CKD caused by chronic latent glomerulonephritis in 65 patients and chronic tubulointerstitial nephritis of various etiologies (gout, drug-induced, and infection) in 25 were examined...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28743129/fibroblast-growth-factor-23-predicts-mortality-and-end-stage-renal-disease-in-a-canadian-asian-population-with-chronic-kidney-disease
#9
Ishwarlal Jialal, Fernando Camacho, Bharat Nathoo, Paul Tam, Roma Pahwa, George G Wu
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Biomarkers that predict end-stage renal disease (ESRD) and/or mortality could usher in new therapeutics to halt this onslaught. While fibroblast growth factor (FGF)23 can predict both ESRD and mortality, it has not been studied in North American CKD patients of Asian ethnicity. METHOD: This is a prospective investigation about the role of FGF23 in 998 Canadian patients of Asian descent with CKD defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/m2 and followed up for 3 years...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28741977/reduction-in-the-presence-of-cryoglobulins-over-time-in-the-hemodialysis-treatment
#10
Tainá Mosca, Simone Sanches Arcuri, Luiz Antônio Miorin, Andrelita de Oliveira Cristiano, Yvoty Alves Dos Santos Sens, Wilma Carvalho Neves Forte
BACKGROUND: The presence of cryoglobulins in patients with chronic kidney disease (CKD) on hemodialysis is well described. However, the generation of cryoglobulins during the dialysis treatment has yet to be established. The aim of the present study was to determine the presence of serum cryoglobulins over time in the dialysis treatment in patients with CKD not infected with hepatitis C virus (HCV). METHOD: Peripheral blood samples were collected at the beginning of dialysis treatment and at 30, 60, 90 and 120 days afterwards...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28740594/opportunities-for-treatment-of-the-hepatitis-c-virus-infected-patient-with-chronic-kidney-disease
#11
REVIEW
Marco Ladino, Fernando Pedraza, David Roth
The prevalence of hepatitis C virus (HCV) infection amongst patients with chronic kidney disease (CKD) and end-stage renal disease exceeds that of the general population. In addition to predisposing to the development of cirrhosis and hepatocellular carcinoma, infection with HCV has been associated with extra-hepatic complications including CKD, proteinuria, glomerulonephritis, cryoglobulinemia, increased cardiovascular risk, insulin resistance, and lymphoma. With these associated morbidities, infection with HCV is not unexpectedly accompanied by an increase in mortality in the general population as well as in patients with kidney disease...
July 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28733158/clinical-and-urodynamic-outcomes-in-children-with-anorectal-malformation-subtype-of-recto-bladder-neck-fistula
#12
A C Strine, B A VanderBrink, Z Alam, M Schulte, P H Noh, W R DeFoor, E Minevich, C A Sheldon, J S Frischer, P P Reddy
INTRODUCTION: Patients with anorectal malformations (ARMs) have a high incidence of genitourinary anomalies. Those with a recto-bladder neck fistula may represent a high-risk group, but their long-term urologic outcomes are poorly described. OBJECTIVE: To evaluate the clinical and urodynamic outcomes in a large cohort of patients with an ARM subtype of recto-bladder neck fistula. MATERIALS AND METHODS: A retrospective cohort study was performed of patients who had been treated for a recto-bladder neck fistula at the present institution since 2007...
July 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28720296/urinary-heat-shock-protein-72-as-a-biomarker-of-acute-kidney-injury-in-dogs
#13
Yaron Bruchim, Yochai Avital, Michal Horowitz, Michal Mazaki-Tovi, Itamar Aroch, Gilad Segev
Early recognition of acute kidney injury (AKI) is important, as therapy is potentially more efficacious if instituted early in the course of disease. Urinary heat shock protein-72 to urinary creatinine ratio (uHSP72/uCr) was assessed as a diagnostic and prognostic marker in AKI in dogs. Fifty-three dogs were enrolled in five groups: healthy controls (n=11), urinary tract infection (n=10), chronic kidney disease (CKD; n=11), AKI (n=13), and acute decompensating CKD (n=8). Urinary heat shock protein-72 to urinary creatinine ratio was highest in the AKI group (P<0...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28708211/direct-acting-antivirals-for-hepatitis-c-virus-in-patients-on-maintenance-dialysis
#14
Fabrizio Fabrizi, Francesca M Donato, Piergiorgio Messa
The frequency of hepatitis C virus (HCV) infection remains high in patients with chronic kidney disease (CKD) and plays a detrimental role in mortality in this population. According to the latest survey, the adjusted hazard ratio for HCV-positive versus HCV-negative patients on long-term dialysis was 1.12 (95% CI, 1.05 to 1.20) and 1.10 (95% CI, 0.98 to 1.22) for all-cause and cardiovascular mortality, respectively. An impairment on quality of life has also been documented in HCV-infected patients undergoing regular dialysis...
July 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28703924/chronic-kidney-disease-in-australian-hiv-infected-patients-analysis-of-the-australian-hiv-observational-database
#15
Jason Cheung, Rainer Puhr, Kathy Petoumenos, David A Cooper, Ian Woolley, Manoji Gunathilake, Nigel Raymond, Rick Varma, Catherine C O'Connor, David M Gracey
AIM: To examine data from the Australian HIV Observational Database (AHOD) to, firstly, describe the incidence of chronic kidney disease (CKD) and rate of loss of renal function in HIV-infected individuals living in Australia, and then to examine the risk factors contributing to CKD in this population. METHODS: AHOD patients over 18 years of age were eligible if they had at least two serum creatinine measurements from 1 April 2008 until 31 March 2016 and an initial estimated glomerular filtration rate (eGFR) greater than 60 mL/min/1...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28678812/augmented-renal-clearance-is-not-a-risk-factor-for-mortality-in-enterobacteriaceae-bloodstream-infections-treated-with-appropriate-empiric-antimicrobials
#16
Jason P Burnham, Scott T Micek, Marin H Kollef
The main objective of the study was to assess whether augmented renal clearance was a risk factor for mortality in a cohort of patients with Enterobacteriaceae sepsis, severe sepsis, or septic shock that all received appropriate antimicrobial therapy within 12 hours. Using a retrospective cohort from Barnes-Jewish Hospital, a 1,250-bed teaching hospital, we collected data on individuals with Enterobacteriaceae sepsis, severe sepsis, and septic shock who received appropriate initial antimicrobial therapy between June 2009 and December 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28674560/-management-of-chronic-hemodialysis-patients-with-anemia-case-study-conducted-in-the-department-of-nephrology-and-hemodialysis-at-the-university-hospital-point-g-in-mali
#17
Alhadji Ahmadou Tounkara, Abdoul Mahama Sériba Coulibaly, Nouhoun Coulibaly, Békaye Traoré, Mahamane Kalil Maïga
INTRODUCTION: Anemia is a frequent complication of Chronic Kidney Disease CKD commonly found in chronic haemodialysis patients. Patients management is mainly based on erythropoietin administration and iron supplementation. This study aimed to evaluate the management of chronic hemodialysis patients with anemia in the Department of Nephrology and Hemodialysis at the University Hospital Point G in Mali. METHODS: We conducted a cross-sectional study from 1 to 31 August 2016...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28668686/impact-of-early-versus-deferred-antiretroviral-therapy-on-estimated-glomerular-filtration-rate-in-hiv-positive-individuals-in-the-start-trial
#18
Amit C Achhra, Amanda Mocroft, Michael Ross, Lene Ryom-Nielson, Anchalee Avihingsanon, Elzbieta Bakowska, Waldo Belloso, Amanda Clarke, Hansjakob Furrer, Gregory M Lucas, Matti Ristola, Mohammed Rassool, Jonathan Ross, Charurut Somboonwit, Shweta Sharma, Christina Wyatt
The impact of early ART initiation (versus deferring) on kidney function has not been studied. START was a randomised comparison of immediate versus deferred ART initiation among HIV-positive persons with CD4(+) (cells/mm(3)) counts >500. Serum creatinine and urine dipstick protein were measured at Months 0, 1, 4, 8 and 12, and annually thereafter. The two arms were compared for changes in eGFR (mL/min/1.73 m(2), calculated by CKD-EPI equation), over time using longitudinal mixed models. Of 4685 START participants, 4629 (2294 in immediate and 2335 deferred arm) were included...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28666756/ampicillin-for-the-treatment-of-complicated-urinary-tract-infections-caused-by-vancomycin-resistant-enterococcus-spp-vre-a-single-center-university-hospital-experience
#19
Kairav J Shah, Kartikeya Cherabuddi, Joseph Shultz, Samuel Borgert, Reuben Ramphal, Kenneth P Klinker
Vancomycin-resistant enterococci are a common cause of urinary tract infections and are typically multi-drug resistant, including ampicillin. This retrospective study evaluated outcomes of 84 adult patients hospitalized between January 2007 and December 2015 with ampicillin and vancomycin resistant-enterococcus isolates causing UTI and treated with ampicillin. Treatment response was classified as clinical cure and microbiological eradication. Clinical cure was achieved in 88.1% (74/84) of patients. In patients with follow up cultures, microbiologic eradication was achieved in 86% (50/58) of patients...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28665281/experimental-model-for-acute-kidney-injury-caused-by-uropathogenic-escherichia-coli
#20
Beata Skowron, Agnieszka Baranowska, Jolanta Kaszuba-Zwoińska, Grażyna Więcek, Anna Malska-Woźniak, Piotr Heczko, Magdalena Strus
INTRODUCTION: Acute kidney injury (AKI) is the rapid deterioration of renal function, diagnosed on the basis of an increase in serum creatinine and abnormal urinary parameters. AKI is associated with increased risk of mortality or chronic kidney disease (CKD). The aim of the study was to develop an experimental model for AKI resulting from Escherichia coli-induced pyelonephritis. E. coli was isolated from a patient with clinical symptoms of urinary tract infection (UTI). MATERIAL/METHODS: The study included three groups of female Wistar rats (groups 1, 2 and 3), in which pyelonephritis was induced by transurethral inoculation with highly virulent E...
June 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
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