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https://www.readbyqxmd.com/read/29771269/upper-gastrointestinal-alterations-in-kidney-transplant-candidates
#1
João Pedro Homse Netto, João Pedro Sant'Anna Pinheiro, Mariana Lopes Ferrari, Mirella Tizziani Soares, Rogério Augusto Gomes Silveira, Mariana Espiga Maioli, Vinicius Daher Alvares Delfino
INTRODUCTION: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. OBJECTIVES: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. METHODS: Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts...
May 14, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29770749/rosuvastatin-and-atorvastatin-preserve-renal-function-in-hiv-1-infected-patients-with-chronic-kidney-disease-and-hyperlipidaemia
#2
Leonardo Calza, Vincenzo Colangeli, Marco Borderi, Roberto Manfredi, Lorenzo Marconi, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND: Hyperlipidaemia is a risk factor for the progression of chronic kidney disease (CKD), which is a frequent comorbidity in patients with HIV-1 infection, but the renal effects of statins remain unclear. METHODS: We performed an observational, prospective study of HIV-infected patients on suppressive antiretroviral therapy, with CKD and hyperlipidaemia, and starting a lipid-lowering treatment with rosuvastatin, atorvastatin or omega-3 fatty acids. CKD was defined as an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1...
June 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29735788/association-between-hepatitis-c-virus-and-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#3
Fabrizio Fabrizi, Francesca M Donato, Piergiorgio Messa
INTRODUCTION: The role of hepatitis C virus infection as a risk factor for the development and progression of chronic kidney disease in the general population remains unclear. MATERIAL AND METHODS: A systematic review of the published medical literature was performed to assess whether positive anti-HCV serologic status is associated with higher frequency of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by lowered glomerular filtration rate or detectable proteinuria) with HCV across the published studies...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29701531/characterization-of-subclinical-bacteriuria-bacterial-cystitis-and-pyelonephritis-in-dogs-with-chronic-kidney-disease
#4
Jonathan D Foster, Harathi Krishnan, Stephen Cole
OBJECTIVE To determine the prevalence of bacteriuria (ie, a positive microbial culture result for ≥ 1 urine sample) in dogs with chronic kidney disease (CKD) and characterize findings of subclinical bacteriuria (SBU), bacterial cystitis, or pyelonephritis in these patients. DESIGN Retrospective, observational study. ANIMALS 182 dogs. PROCEDURES Medical records from January 2010 through July 2015 were reviewed to identify dogs with CKD that underwent urinalysis and urine microbial culture. Signalment, clinicopathologic data, stage of CKD according to previously published guidelines, results of urinalysis and urine culture, and abdominal ultrasonographic findings were recorded...
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29694730/rationale-for-treating-hepatitis-c-virus-infection-in-patients-with-mild-to-moderate-chronic-kidney-disease
#5
REVIEW
Ezequiel Ridruejo, Manuel Mendizabal, Marcelo O Silva
Hepatitis C virus infection (HCV) is highly prevalent in patients with chronic kidney disease (CKD) and kidney transplant recipients. Little information exists on treatment in patients with CKD stages 2 to 3, where CKD progression might be slowed by HCV treatment. These patients are not considered a high priority for HCV treatment in most international guidelines. Although some recently published guidelines propose universal treatment, others are still recommending it only in high priority groups. In this review, we evaluate current evidence of HCV infection impact on CKD progression, on cardiovascular and metabolic risk, and the benefits of HCV infection treatment to improve cardiovascular and metabolic outcomes...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29694726/treatment-and-management-options-for-the-hepatitis-c-virus-infected-kidney-transplant-candidate
#6
REVIEW
Adriana Dejman, Marco A Ladino, David Roth
A substantial body of literature has unequivocally established that prevalent hepatitis C virus infection in chronic kidney disease (CKD), end stage renal disease (ESRD) and kidney transplant recipients is associated with a negative impact on patient survival. As a consequence of remarkable work that explained the details of the hepatitis C virus (HCV) genome, a class of drugs referred to as the direct-acting antiviral (DAA) agents were developed that targeted specific key sites in viral replication. Large clinical trials in the HCV-infected general population followed soon after that demonstrated cure rates exceeding 95%...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29688533/plasma-cystatin-c-as-a-marker-for-estimated-glomerular-filtration-rate-assessment-in-hiv-1-infected-patients-treated-with-dolutegravir-based-art
#7
Romain Palich, Roland Tubiana, Besma Abdi, Fouzi Mestari, Marguerite Guiguet, Françoise Imbert-Bismut, Christine Katlama, Dominique Bonnefont-Rousselot, Corinne Isnard-Bagnis
Objectives: Inhibition of the organic cation transporter-2 renal tubule transporter by dolutegravir leads to serum creatinine increase. Serum cystatin C is a non-organic cation transporter-2-dependent marker, possibly enabling glomerular filtration rate (GFR) estimation under dolutegravir. Our goal was to evaluate the changes in creatinine- and cystatin C-based estimated GFR values before and after dolutegravir initiation. Methods: Creatinine and cystatin measurements were carried out on frozen plasma samples from HIV-1-infected patients, before and after dolutegravir initiation, between October 2016 and March 2017 at Pitié-Salpêtrière Hospital...
April 24, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29686466/nutrition-status-and-helicobacter-pylori-infection-in-patients-receiving-hemodialysis
#8
REVIEW
Mitsushige Sugimoto, Hideo Yasuda, Akira Andoh
Chronic kidney disease (CKD) patients receiving hemodialysis (HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting (PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori ( H. pylori ) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin levels that are seen in malnutrition...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29676846/generic-sofosbuvir-based-direct-acting-antivirals-in-hepatitis-c-virus-infected-patients-with-chronic-kidney-disease
#9
Manoj Kumar Sharma, Suman Lata Nayak, Ekta Gupta, Ashish Kataria, Shiv K Sarin
BACKGROUND & AIMS: There is scant data on use of sofosbuvir containing directly acting anti-viral (DAA) regimens in chronic kidney disease (CKD) patients. Recently generic versions of DAAs have become available in low income countries including India. The aim of this study was to study the efficacy and safety of generic sofosbuvir in combination with generic ribavirin, ledipasvir, or daclatasvir in HCV infected patients with CKD including patients with advanced CKD (CKD stage 4 or 5 with an estimated glomerular filtration rate (GFR) <30 mL/min or those on dialysis)...
April 20, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29668591/prevalence-and-correlates-of-chronic-kidney-disease-ckd-among-art-naive-hiv-patients-in-the-niger-delta-region-of-nigeria
#10
Udeme E Ekrikpo, Andre P Kengne, Effiong E Akpan, Emmanuel E Effa, Aminu K Bello, John U Ekott, Cindy George, Babatunde L Salako, Ikechi G Okpechi
Widespread use of antiretroviral therapy (ART) in human immunodeficiency virus (HIV) patients has led to improved longevity with the attendant increase in noncommunicable disease prevalence including chronic kidney disease (CKD). This study documents the prevalence of CKD in a large HIV population in Southern Nigeria.This is a single center, 15-year analysis in ART-naïve patients. CKD was defined as the occurrence of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m on 2 consecutive occasions 3 to 12 months apart using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666917/measurement-of-iron-status-in-chronic-kidney-disease
#11
Wesley Hayes
Anemia is a common complication of chronic kidney disease (CKD) in children, and dysregulation of iron homeostasis plays a central role in its pathogenesis. Optimizing iron status is a prerequisite for effective treatment of anemia. Insufficient iron can lead to inappropriate escalation of the erythropoiesis-stimulating agent (ESA) dose, which is associated with adverse outcomes. Excess iron supplementation also has negative sequelae including free radical tissue damage and increased risk of systemic infection...
April 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29659606/humoral-immunity-to-memory-antigens-and-pathogens-is-maintained-in-patients-with-chronic-kidney-disease
#12
Nadezhda A Wall, C Coral Dominguez-Medina, Sian E Faustini, Charlotte N Cook, Andrew McClean, Mark D Jesky, Marisol Perez-Toledo, Matthew D Morgan, Alexandra G Richter, Charles J Ferro, Paul Cockwell, Paul A Moss, Ian R Henderson, Lorraine Harper, Adam F Cunningham
Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients have an impaired responsiveness to all antigens, even those first encountered before CKD onset. To examine this we evaluated antibody responses against two childhood vaccine antigens, tetanus (TT) and diphtheria toxoids (DT) and two common pathogens, cytomegalovirus (CMV) and Salmonella enterica serovar Enteritidis (SEn) in two independent cohorts consisting of age-matched individuals with and without CKD...
2018: PloS One
https://www.readbyqxmd.com/read/29659605/chronic-kidney-disease-in-the-global-adult-hiv-infected-population-a-systematic-review-and-meta-analysis
#13
Udeme E Ekrikpo, Andre P Kengne, Aminu K Bello, Emmanuel E Effa, Jean Jacques Noubiap, Babatunde L Salako, Brian L Rayner, Giuseppe Remuzzi, Ikechi G Okpechi
INTRODUCTION: The widespread use of antiretroviral therapies (ART) has increased life expectancy in HIV patients, predisposing them to chronic non-communicable diseases including Chronic Kidney Disease (CKD). We performed a systematic review and meta-analysis (PROSPERO registration number CRD42016036246) to determine the global and regional prevalence of CKD in HIV patients. METHODS: We searched PubMed, Web of Science, EBSCO and AJOL for articles published between January 1982 and May 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29623673/the-relationship-between-age-and-chronic-kidney-disease-in-patients-undergoing-pancreatic-resection
#14
Derrick Antoniak, Chandrakanth Are, Chad Vokoun, Kaeli Samson, Lynette Smith, Jason Shiffermiller
BACKGROUND: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65. METHODS: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery...
April 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29602711/tenofovir-disoproxil-fumarate-co-administered-with-lopinavir-ritonavir-is-strongly-associated-with-tubular-damage-and-chronic-kidney-disease
#15
Daisuke Mizushima, Dung Thi Hoai Nguyen, Dung Thi Nguyen, Shoko Matsumoto, Junko Tanuma, Hiroyuki Gatanaga, Nguyen Vu Trung, Nguyen van Kinh, Shinichi Oka
BACKGROUD: With expanding antiretroviral therapy (ART) in a resource-limited setting, the use of second line ART with ritonavir boosted lopinavir (LPV/r) is increasing. However, little is known regarding the renal safety of tenofovir (TDF) co-administered with LPV/r. METHODS: In total 1382 HIV-infected patients were enrolled and data were recorded twice (October 2014 and 2015) in Vietnam. Tubular dysfunction (TD) was defined as urinary beta 2 microglobulin (β2MG) > 1000 μg/L at both timepoints or increase in β2MG by > 2000 μg/L...
March 27, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29580582/inflammatory-mechanisms-as-new-biomarkers-and-therapeutic-targets-for-diabetic-kidney-disease
#16
REVIEW
Radica Z Alicic, Emily J Johnson, Katherine R Tuttle
Diabetic kidney disease (DKD) is the leading cause of CKD and end-stage kidney disease (ESKD) worldwide. Approximately 30-40% of people with diabetes develop this microvascular complication, placing them at high risk of losing kidney function as well as of cardiovascular events, infections, and death. Current therapies are ineffective for arresting kidney disease progression and mitigating risks of comorbidities and death among patients with DKD. As the global count of people with diabetes will soon exceed 400 million, the need for effective and safe treatment options for complications such as DKD becomes ever more urgent...
March 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29573131/achieving-sustained-virologic-response-in-liver-transplant-recipients-with-hepatitis-c-decreases-risk-of-decline-in-renal-function
#17
Sanjaya K Satapathy, Kiran Joglekar, Miklos Z Molnar, Bilal Ali, Humberto C Gonzalez, Jason M Vanatta, James D Eason, Satheesh P Nair
BACKGROUND: The effect of anti-viral therapy (AVT) on kidney function in liver transplant (LT) recipients has not been well described despite known association of hepatitis C virus (HCV) infection with chronic kidney disease (CKD). METHODS: We compared the incidence of CKD, and end-stage renal disease (ESRD) in 204 LT recipients with HCV based on treatment response to AVT. RESULTS: The median eGFR at baseline (3 months post-LT) was similar in the SVR (n=145) and non-SVR group (n=59) (69±21 vs...
March 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29572949/detection-and-seroprevalence-of-morbillivirus-and-other-paramyxoviruses-in-geriatric-cats-with-and-without-evidence-of-azotemic-chronic-kidney-disease
#18
Katie Elizabeth McCallum, Sam Stubbs, Nicholas Hope, Ian Mickleburgh, Dave Dight, Laurence Tiley, Tim L Williams
BACKGROUND: Feline morbillivirus (FeMV) is associated with the presence of tubulo-interstitial nephritis (TIN) in cats, however the seroprevalence of FeMV in the UK and the association between the presence of FeMV and renal azotemia is unknown HYPOTHESIS/OBJECTIVES: To identify whether paramyxoviruses are present in urine samples of geriatric cats and to develop an assay to assess FeMV seroprevalence. To investigate the relationship between both urinary paramyxovirus (including FeMV) excretion and FeMV seroprevalence and azotemic chronic kidney disease (CKD)...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29552953/extended-mortality-and-chronic-kidney-disease-after-septic-acute-kidney-injury
#19
Horng-Ruey Chua, Weng-Kin Wong, Venetia Huiling Ong, Dipika Agrawal, Anantharaman Vathsala, Hui-Ming Tay, Amartya Mukhopadhyay
PURPOSE: To evaluate 1-year mortality in patients with septic acute kidney injury (AKI) and to determine association between initial AKI recovery patterns ( reversal within 5 days, beyond 5 days but recovery, or nonrecovery) and chronic kidney disease (CKD) progression. METHODS: Prospective observational study, with retrospective evaluation of initial nonconsenters, of critically ill patients with septic AKI. RESULTS: We studied 207 patients (age, mean [SD]: 64 [16] years, 39% males), of which 56 (27%), 18 (9%), and 9 (4%) died in intensive care unit (ICU), post-ICU in hospital, and posthospitalization, respectively...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29537127/successful-pregnancy-outcomes-following-liver-transplantation-is-predicted-by-renal-function
#20
Tiong Y Lim, Enoka Gonsalkorala, Mary D Cannon, Stella Gabeta, Leonie Penna, Nigel D Heaton, Michael A Heneghan
BACKGROUND: Liver transplantation (LT) is a successful treatment for both acute liver failure and end-stage liver disease. The number of women of reproductive age undergoing LT is increasing. Pregnancy outcomes are favourable but there is still a lack of prognostic markers. We aimed to identify factors predictive of adverse pregnancy outcomes in LT recipients. METHODS: An analysis of all pregnancies occurring in LT recipients from 1989-2016 at King's College Hospital was performed...
March 14, 2018: Liver Transplantation
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