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Suzanne Somers

Marjan Vanheusden, Bieke Broux, Suzanne P M Welten, Liesbet M Peeters, Eleni Panagioti, Bart Van Wijmeersch, Veerle Somers, Piet Stinissen, Ramon Arens, Niels Hellings
Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4(+)CD28(null) T cells are only present in CMV seropositive donors and that CMV-specific Immunoglobulin (Ig) G titers correlate with the percentage of these cells. In vitro stimulation of peripheral blood mononuclear cells with CMVpp65 peptide resulted in the expansion of pre-existing CD4(+)CD28(null) T cells. In vivo, we observed de novo formation, as well as expansion of CD4(+)CD28(null) T cells in two different chronic inflammation models, namely the murine CMV (MCMV) model and the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis (MS)...
April 6, 2017: Scientific Reports
Nicole H T M Dukers-Muijrers, Carlijn Somers, Hanneke de Graaf, Suzanne Meijer, Christian J P A Hoebe
BACKGROUND: Non-volitional sex (NVS) in young people continues to be a major public health problem with long-term negative health outcomes. For the first time, the prevalence of different types of NVS and associated factors are compared between young people with same-sex sexual activities and those who have not. METHODS: We obtained data from 10,401 young women and men (aged 12 to 25 years) who participated in a population study on sexual health, the Netherlands...
2015: PloS One
Howard Trachtman, Suzanne Vento, Emily Herreshoff, Milena Radeva, Jennifer Gassman, Daniel T Stein, Virginia J Savin, Mukut Sharma, Jochen Reiser, Changli Wei, Michael Somers, Tarak Srivastava, Debbie S Gipson
BACKGROUND: Patients with resistant focal segmental glomerulosclerosis (FSGS) who are unresponsive to corticosteroids and other immunosuppressive agents are at very high risk of progression to end stage kidney disease. In the absence of curative treatment, current therapy centers on renoprotective interventions that reduce proteinuria and fibrosis. The FONT (Novel Therapies for Resistant FSGS) Phase II clinical trial (NCT00814255, Registration date December 22, 2008) was designed to assess the efficacy of adalimumab and galactose compared to standard medical therapy which was comprised of lisinopril, losartan, and atorvastatin...
July 22, 2015: BMC Nephrology
Allison Christian, Shawna V Hudson, Suzanne M Miller, Alicja Bator, Pamela A Ohman-Strickland, Robert A Somer, Jeanne Ferrante
BACKGROUND: Obese breast cancer survivors (BCSs) are impacted by diminished quality of life (QOL), multiple comorbid conditions, and poor disease outcomes. Despite national guidelines recommending a healthy weight to improve QOL and outcomes posttreatment, support and education are not routinely provided to BCSs in primary care. To fill this gap, we assessed perceptions of primary care received among BCSs by weight status. METHODS: Cross-sectional surveys were administered to early-stage BCSs (N = 188) from 2 New Jersey cancer centers between May 2012 and July 2013...
January 2015: Health Services Research and Managerial Epidemiology
Anthony J Bleyer, Stanislav Kmoch, Corinne Antignac, Vicki Robins, Kendrah Kidd, John R Kelsoe, Gerald Hladik, Philip Klemmer, Stephen J Knohl, Steven J Scheinman, Nam Vo, Ann Santi, Alese Harris, Omar Canaday, Nelson Weller, Peter J Hulick, Kristen Vogel, Frederick F Rahbari-Oskoui, Jennifer Tuazon, Constantinos Deltas, Douglas Somers, Andre Megarbane, Paul L Kimmel, C John Sperati, Avi Orr-Urtreger, Shay Ben-Shachar, David A Waugh, Stella McGinn, Anthony J Bleyer, Katerina Hodanová, Petr Vylet'al, Martina Živná, Thomas C Hart, P Suzanne Hart
BACKGROUND AND OBJECTIVES: The genetic cause of medullary cystic kidney disease type 1 was recently identified as a cytosine insertion in the variable number of tandem repeat region of MUC1 encoding mucoprotein-1 (MUC1), a protein that is present in skin, breast, and lung tissue, the gastrointestinal tract, and the distal tubules of the kidney. The purpose of this investigation was to analyze the clinical characteristics of families and individuals with this mutation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Families with autosomal dominant interstitial kidney disease were referred for genetic analysis over a 14-year period...
March 2014: Clinical Journal of the American Society of Nephrology: CJASN
Maaike G J Gademan, Henk J van Exel, Hedde van de Vooren, Joris C W Haest, Johannes van Pelt, Arnoud van der Laarse, Suzanne C Cannegieter, Carolien M H B Lucas, Soeresh Somer, Harriette F Verwey, Martin J Schalij, Ernst E van der Wall, Cees A Swenne
BACKGROUND: The mechanism of the beneficial effects of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure (CHF) is largely unexplained. In our here-presented hypothesis-generating study we propose that part of these effects is mediated by the exercise-accompanying somatosensory nerve traffic. To demonstrate this, we compared the effects of periodic electrical somatosensory stimulation in patients with CHF with the effects of exercise training and with usual care...
October 9, 2013: International Journal of Cardiology
James P Stevenson, Corey J Langer, Robert A Somer, Tracey L Evans, Kumar Rajagopalan, Kimberly Krieger, Mona Jacobs-Small, Nikolas Dyanick, Barry Milcarek, Susan Coakley, Suzanne Walker, Beth Eaby-Sandy, Alexandre Hageboutros
BACKGROUND: The authors performed a phase 2 study of bevacizumab plus pemetrexed and carboplatin followed by maintenance bevacizumab in patients with advanced, nonsquamous nonsmall cell lung cancer. METHODS: Previously untreated patients with advanced, nonsquamous nonsmall cell lung cancer and an Eastern Cooperative Oncology Group performance status of 0 or 1 received bevacizumab 15 mg/kg, pemetrexed 500 mg/m(2) and carboplatin at an area under the concentration-time curve of 6 intravenously on day 1 every 21 days...
November 15, 2012: Cancer
Howard Trachtman, Suzanne Vento, Debbie Gipson, Larysa Wickman, Jennifer Gassman, Melanie Joy, Virginia Savin, Michael Somers, Maury Pinsk, Tom Greene
BACKGROUND: The lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in patients who fail to respond to corticosteroids and immunosuppressive therapies. Recent basic science advances have led to development of alternative treatments that specifically target aberrant pathways of fibrosis which are relevant to disease progression in FSGS. There is a need for a flexible Phase II study design which will test such novel antifibrotic strategies in order to identify agents suitable for phase III testing...
February 10, 2011: BMC Nephrology
Ludovic de Beaucoudrey, Arina Samarina, Jacinta Bustamante, Aurélie Cobat, Stéphanie Boisson-Dupuis, Jacqueline Feinberg, Saleh Al-Muhsen, Lucile Jannière, Yoann Rose, Maylis de Suremain, Xiao-Fei Kong, Orchidée Filipe-Santos, Ariane Chapgier, Capucine Picard, Alain Fischer, Figen Dogu, Aydan Ikinciogullari, Gonul Tanir, Sami Al-Hajjar, Suliman Al-Jumaah, Husn H Frayha, Zobaida AlSum, Sulaiman Al-Ajaji, Abdullah Alangari, Abdulaziz Al-Ghonaium, Parisa Adimi, Davood Mansouri, Imen Ben-Mustapha, Judith Yancoski, Ben-Zion Garty, Carlos Rodriguez-Gallego, Isabel Caragol, Necil Kutukculer, Dinakantha S Kumararatne, Smita Patel, Rainer Doffinger, Andrew Exley, Olle Jeppsson, Janine Reichenbach, David Nadal, Yaryna Boyko, Barbara Pietrucha, Suzanne Anderson, Michael Levin, Liliane Schandené, Kinda Schepers, André Efira, Françoise Mascart, Masao Matsuoka, Tatsunori Sakai, Claire-Anne Siegrist, Klara Frecerova, Renate Blüetters-Sawatzki, Jutta Bernhöft, Joachim Freihorst, Ulrich Baumann, Darko Richter, Filomeen Haerynck, Frans De Baets, Vas Novelli, David Lammas, Christiane Vermylen, David Tuerlinckx, Chris Nieuwhof, Malgorzata Pac, Walther H Haas, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Jacob Levy, Revathi Raj, Aileen Cleary Cohen, David B Lewis, Steven M Holland, Kuender D Yang, Xiaochuan Wang, Xiaohong Wang, Liping Jiang, Xiqiang Yang, Chaomin Zhu, Yuanyuan Xie, Pamela Pui Wah Lee, Koon Wing Chan, Tong-Xin Chen, Gabriela Castro, Ivelisse Natera, Ana Codoceo, Alejandra King, Liliana Bezrodnik, Daniela Di Giovani, Maria Isabel Gaillard, Dewton de Moraes-Vasconcelos, Anete Sevciovic Grumach, Alberto Jose da Silva Duarte, Ruth Aldana, Francisco Javier Espinosa-Rosales, Mohammed Bejaoui, Ahmed Aziz Bousfiha, Jamila El Baghdadi, Namik Ozbek, Guzide Aksu, Melike Keser, Ayper Somer, Nevin Hatipoglu, Cigdem Aydogmus, Suna Asilsoy, Yildiz Camcioglu, Saniye Gülle, Tuba T Ozgur, Meteran Ozen, Matias Oleastro, Andrea Bernasconi, Setareh Mamishi, Nima Parvaneh, Sergio Rosenzweig, Ridha Barbouche, Sigifredo Pedraza, Yu Lung Lau, Mohammad S Ehlayel, Claire Fieschi, Laurent Abel, Ozden Sanal, Jean-Laurent Casanova
Interleukin-12 receptor β1 (IL-12Rβ1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an international survey of 141 patients from 102 kindreds in 30 countries. Among 102 probands, the first infection occurred at a mean age of 2.4 years. In 78 patients, this infection was caused by Bacille Calmette-Guérin (BCG; n = 65), environmental mycobacteria (EM; also known as atypical or nontuberculous mycobacteria) (n = 9) or Mycobacterium tuberculosis (n = 4)...
November 2010: Medicine (Baltimore)
Richard Angell, Nicola M Aston, Paul Bamborough, Jacky B Buckton, Stuart Cockerill, Suzanne J deBoeck, Chris D Edwards, Duncan S Holmes, Katherine L Jones, Dramane I Laine, Shila Patel, Penny A Smee, Kathryn J Smith, Don O Somers, Ann L Walker
The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.
August 1, 2008: Bioorganic & Medicinal Chemistry Letters
Gino R Somers, Maria Zielenska, Shaker Abdullah, Christopher Sherman, Suzanne Chan, Paul S Thorner
Synovial sarcoma accounts for between 6 and 10% of childhood sarcomas and histological diagnosis can be challenging, even for experienced pathologists. Several other tumors enter the differential diagnosis, including malignant peripheral nerve sheath tumor, Ewing sarcoma/primitive neuroectodermal tumor and undifferentiated sarcoma. Several recent reports utilizing expression array techniques have documented expression of the MYCN oncogene in synovial sarcoma. In order to more fully investigate this finding, a series of 12 synovial sarcomas and 29 other sarcomas (four malignant peripheral nerve sheath tumors, 15 Ewing sarcoma/primitive neuroectodermal tumors, 10 undifferentiated sarcomas) were examined for MYCN expression and gene amplification...
July 2007: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Charles Kunsch, Jayraz Luchoomun, Xi-Lin Chen, Geraldine L Dodd, Kanika S Karu, Charles Q Meng, Elaine M Marino, Lyn K Olliff, J Daniel Piper, Fei-Hua Qiu, James A Sikorski, Patricia K Somers, Ki-Ling Suen, Suzanne Thomas, Anne M Whalen, Martin A Wasserman, Cynthia L Sundell
The pathogenesis of chronic inflammatory diseases, including rheumatoid arthritis, is regulated, at least in part, by modulation of oxidation-reduction (redox) homeostasis and the expression of redox-sensitive inflammatory genes including adhesion molecules, chemokines, and cytokines. AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid] is a novel, orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties...
May 2005: Journal of Pharmacology and Experimental Therapeutics
Vladimir M Ognenovski, Wendy Marder, Emily C Somers, Carolyn M Johnston, Janice G Farrehi, Suzanne M Selvaggi, W Joseph McCune
OBJECTIVE: To determine if the incidence of cervical intraepithelial neoplasia (CIN) is increased in immunosuppressed women with systemic lupus erythematosus (SLE). METHODS: Women with SLE were consecutively recruited from University of Michigan outpatient rheumatology clinics. Women with abnormal cervical smears at screening were excluded. Cervical smears were obtained at baseline and at 3 and 7 years. Cervical biopsies confirmed cytologic abnormalities (CIN I-III), and were scored by pathologists in blinded fashion...
September 2004: Journal of Rheumatology
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