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https://www.readbyqxmd.com/read/29692073/-effects-of-different-tillage-patterns-on-soil-properties-maize-yield-and-water-use-efficiency-in-weibei-highland-china
#1
Dan Liu, Xia Zhang, Jun Li, Xu-Dong Wang
An eight-year field experiment of straw returning was conducted on dark loessial soil in Weibei Highland to investigate the effects of tillage patterns on soil aggregate, soil organic carbon (SOC), corn yield and soil water use efficiency (WUE). There were six tillage patterns, including conventional tillage (CT/CT), no-tillage (NT/NT), subsoiling tillage (ST/ST), no-tillage/subsoiling tillage (NT/ST), conventional tillage/no-tillage (CT/NT) and conventional tillage/subsoiling tillage (CT/ST). The results showed that compared with CT/CT, the patterns of NT/NT, ST/ST and the rotational tillage patterns (NT/ST, CT/NT and CT/ST) decreased the mean mass diameter of soil mechanical stable aggregate...
February 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29691812/excipient-selection-and-aerodynamic-characterization-of-nebulized-lipid-based-nanoemulsion-loaded-with-docetaxel-for-lung-cancer-treatment
#2
Azren Aida Asmawi, Norazlinaliza Salim, Cheng Loong Ngan, Haslina Ahmad, Emilia Abdulmalek, Mas Jaffri Masarudin, Mohd Basyaruddin Abdul Rahman
Docetaxel has demonstrated extraordinary anticancer effects on lung cancer. However, lack of optimal bioavailability due to poor solubility and high toxicity at its therapeutic dose has hampered the clinical use of this anticancer drug. Development of nanoemulsion formulation along with biocompatible excipients aimed for pulmonary delivery is a potential strategy to deliver this poorly aqueous soluble drug with improved bioavailability and biocompatibility. In this work, screening and selection of pharmaceutically acceptable excipients at their minimal optimal concentration have been conducted...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691811/chemico-calorimetric-analysis-of-amorphous-granules-manufactured-via-continuous-granulation-process
#3
Mridul Majumder, Saeid Rajabnezhad, Ali Nokhodchi, Mohammed Maniruzzaman
The current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)-a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691788/tissue-identification-in-a-porcine-model-by-differential-ion-mobility-spectrometry-analysis-of-surgical-smoke
#4
Anton Kontunen, Markus Karjalainen, Jukka Lekkala, Antti Roine, Niku Oksala
Electrosurgery is widely used in various surgical operations. When tissue is cut with high-frequency current, the cell contents at the incision area evaporate and together with water and possible soot particles, form surgical smoke. The smoke contains cell metabolites, and therefore, possible biomarkers for cancer or bacterial infection. Thus, the analysis of surgical smoke could be used in intraoperative medical diagnostics. We present a method that can be used to detect the characteristics of various tissue types by means of differential ion mobility spectrometry (DMS) analysis of surgical smoke...
April 24, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29691787/the-role-of-circle-of-willis-anatomy-variations-in-cardio-embolic-stroke-a-patient-specific-simulation-based-study
#5
Debanjan Mukherjee, Neel D Jani, Jared Narvid, Shawn C Shadden
We describe a patient-specific simulation based investigation on the role of Circle of Willis anatomy in cardioembolic stroke. Our simulation framework consists of medical image-driven modeling of patient anatomy including the Circle, 3D blood flow simulation through patient vasculature, embolus transport modeling using a discrete particle dynamics technique, and a sampling based approach to incorporate parametric variations. A total of 24 (four patients and six Circle anatomies including the complete Circle) models were considered, with cardiogenic emboli of varying sizes and compositions released virtually and tracked to compute distribution to the brain...
April 24, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29691784/contamination-characteristics-of-trace-metals-in-dust-from-different-levels-of-roads-of-a-heavily-air-polluted-city-in-north-china
#6
Zhiguo Cao, Qiaoying Chen, Xiaoying Wang, Yajie Zhang, Shihua Wang, Mengmeng Wang, Leicheng Zhao, Guangxuan Yan, Xin Zhang, Ziyang Zhang, Tianfang Yang, Mohai Shen, Jianhui Sun
Concentrations of eight trace metals (TMs) in road dust (RD) (particles < 25 μm) from urban areas of Xinxiang, China, were determined by inductively coupled plasma mass spectrometry. The geometric mean concentrations of Zn, Mn, Pb, As, Cu, Cr, Ni and Cd were 489, 350, 114, 101, 60.0, 39.7, 31.6, and 5.1 mg kg-1 , respectively. When compared with TM levels in background soil, the samples generally display elevated TM concentrations, except for Cr and Mn, and for Cd the enrichment value was 69.6. Spatial variations indicated TMs in RD from park path would have similar sources with main roads, collector streets and bypasses...
April 24, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29691753/bioactivity-safety-and-efficacy-of-amphotericin-b-nanomicellar-aerosols-using-sodium-deoxycholate-sulfate-as-the-lipid-carrier
#7
Faisal Usman, Ruqaiya Khalil, Zaheer Ul-Haq, Titpawan Nakpheng, Teerapol Srichana
We report nanomicelles of amphotericin B (AmB) using various molar ratios of AmB and sodium deoxycholate sulfate (SDCS) for inhalation with improved stability, solubility, bioactivity, and safety. The particle sizes of all aerosolized formulations are expressed as mass median aerodynamic diameter (0.9-1.6 μm), fine particle fraction (70.3-86.5%), and geometric standard deviation (1.4-2.1) which indicated their sizes are appropriate for use as an inhaler. In vitro cytotoxicity studies conducted using respiratory and kidney cell lines demonstrated that the marketed Fungizone® was toxic to macrophage and embryonic kidney cells and cell viability decreased from 96 to 48% and from 97 to 67%, respectively when the AmB equivalent concentration was increased from 1 to 16 μg/mL...
April 24, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29691749/determination-of-size-segregated-elements-in-diesel-biodiesel-blend-exhaust-emissions
#8
Luiz Diego Silva Rocha, Sergio Machado Corrêa
This study was based on the determination of metals in particulate matter emitted by a typical diesel engine used by busses and trucks in Brazil. Emissions were sampled using a cascade impactor, and the engine was operated using diesel with 5% (B5), 10% (B10), 15% (B15), and 20% (B20) of biodiesel. The particulate matter was stratified in different sizes, i.e., 18, 5.6, 3.2, 1.8, 1.0, 0.560, 0.320, 0.180, 0.100, and 0.056 μm. Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, V, and Zn with concentrations within 10 to 1000 ng m-3 were determined...
April 24, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29691748/intestinal-microbiome-of-broiler-chickens-after-use-of-nanoparticles-and-metal-salts
#9
Еlena Yausheva, Sergey Miroshnikov, Еlena Sizova
The research included the study of influence of ultrafine particle preparations (nanoparticles of copper, zinc, iron, CuZn alloy) and metal salts (iron pyrophosphate, copper asparginate, zinc asparginate) on the composition of cecal microbiota of broiler chickens. Before adding the studied nanoparticles and metal salts to the diet, cecal microbiota of broiler chickens was represented by 76% Firmicutes taxon and 16% Bacteroidetes. Numerous among them were the bacteria of the taxa Anaerotruncus spp., Lactobacillus spp...
April 24, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29691725/preparation-and-application-of-melamine-cross-linked-poly-ammonium-as-shale-inhibitor
#10
Li Zhang, Tiehu Li, Lei Huang, Zhengqin Ye, Zhongbin Ye, Xin Yan, Lili Li, Qiang Deng, Gang Chen, Jie Zhang, Zhifang Zhang
In this paper, a series of poly ammonium shale inhibitors were prepared from diethylamine, epichlorohydrin, and melamine (DEM) and their inhibition to shale were evaluated by bentonite linear expansion test, anti-swelling experiments, and mud ball experiments. Additionally, other properties of drilling fluid treated by poly ammonium were evaluated. Anti-swelling results showed that anti-swelling rate of DEM-8 reaches up to 97.8% when its concentration reaches to 0.8%. Mud ball experiment and drilling fluid evaluation showed DEM-8 has strong inhibitive capability to bentonite hydration swelling and controlling the particle size of bentonite in a large scale...
April 25, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29691684/semi-automatic-methods-for-airway-and-adjacent-vessel-measurement-in-bronchiectasis-patterns-in-lung-hrct-images-of-cystic-fibrosis-patients
#11
REVIEW
Zeinab Naseri, Soghra Sherafat, Hamid Abrishami Moghaddam, Mohammadreza Modaresi, Neda Pak, Fatemeh Zamani
Airway and vessel characterization of bronchiectasis patterns in lung high-resolution computed tomography (HRCT) images of cystic fibrosis (CF) patients is very important to compute the score of disease severity. We propose a hybrid and evolutionary optimized threshold and model-based method for characterization of airway and vessel in lung HRCT images of CF patients. First, the initial model of airway and vessel is obtained using the enhanced threshold-based method. Then, the model is fitted to the actual image by optimizing its parameters using particle swarm optimization (PSO) evolutionary algorithm...
April 24, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29691551/-experimental-research-of-hot-alkaline-solution-etching-treatment-on-zirconia-resin-bonding-strength
#12
Li-Yang Wan, Hong-Shui Zhu
PURPOSE: In this experiment, we applied hot alkaline solution (20%NaOH solutions) to treat the surfaces of zirconia ceramics in vitro, then evaluated the changes of bond strength of zirconia ceramics and resin cement. METHODS: Eighteen pieces of zirconia ceramic specimens were made, using the same method of grinding and polishing, and then randomly divided them into 3 groups: group A with hot alkali solution treatment (20%NaOH) (n=6), group B underwent sand blasting with a diameter of 110 ?m alumina particles (n=6), group C was as the control group...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691531/facile-preparation-of-multifunctionalisable-stealth-upconverting-nanoparticles-for-biomedical-applications
#13
Anne Nsubuga, Massimo Sgarzi, Kristof Zarschler, Manja Kubeil, René Hübner, Robin Steudtner, Bim Graham, Tanmaya Joshi, Holger Stephan
Pure hexagonal (β-phase) NaYF4-based hydrophobic upconverting nanoparticles (UCNPs) were surface-modified with O-phospho-l-threonine (OPLT), alendronic acid, and PEG-phosphate ligands to generate water-dispersible UCNPs. Fourier-transform infrared (FTIR) spectroscopy was used to establish the presence of the ligands on the UCNP surface. These UCNPs exhibit great colloidal stability and a near-neutral surface at physiological pH, as confirmed by dynamic light scattering (DLS) and zeta potential (ζ) measurements, respectively...
April 25, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29691477/adsorption-properties-of-granular-activated-carbon-supported-titanium-dioxide-particles-for-dyes-and-copper-ions
#14
Xin Zheng, Nannan Yu, Xiaopeng Wang, Yuhong Wang, Linshan Wang, Xiaowu Li, Xiaomin Hu
In the present paper, granular activated carbon (GAC) supported titanium dioxide (TiO2 @GAC) particles were prepared by sol-gel process. Their performance in simultaneous adsorption of dye and Cu2+ from wastewater was studied. X-ray diffraction (XRD) indicated that TiO2 of the TiO2 @GAC microsphere is anatase type, and Fourier transform infrared spectroscopy (FT-IR) showed that the samples have obvious characteristic peaks in 400-800 cm-1 , which indicated that there are Ti-O-Ti bonds. The experimental results showed that the adsorption of TiO2 @GAC for Methylene blue (MB) and Cu2+ were favorable under acidity condition, the adsorption of Methyl orange (MO) was favorable under alkalecent condition...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691459/unexpected-impact-of-radiation-friction-enhancing-production-of-longitudinal-plasma-waves
#15
Evgeny Gelfer, Nina Elkina, Alexander Fedotov
We study the penetration of ultra-intense (intensity I [Formula: see text] 1023-24  W/cm2 ) circularly polarized laser pulses into a thick subcritical plasma layer with accounting for radiation friction. We show that radiation pressure is enhanced due to radiation friction in the direction transverse to the laser pulse propagation, and that for stronger and longer laser pulses this mechanism dominates over the ordinary ponderomotive pressure, thus resulting in a substantionaly stronger charge separation than anticipated previously...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691453/author-correction-particles-of-different-sizes-and-shapes-induce-neutrophil-necroptosis-followed-by-the-release-of-neutrophil-extracellular-trap-like-chromatin
#16
Jyaysi Desai, Orestes Foresto-Neto, Mohsen Honarpisheh, Stefanie Steiger, Daigo Nakazawa, Bastian Popper, Eva Miriam Buhl, Peter Boor, Shrikant R Mulay, Hans-Joachim Anders
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691437/immunological-responses-following-administration-of-a-genotype-1a-1b-2-3a-quadrivalent-hcv-vlp-vaccine
#17
D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, D C Jackson, Z Y Keck, S K H Foung, H E Drummer, E J Gowans, J Torresi
The significant public health problem of Hepatitis C virus (HCV) has been partially addressed with the advent of directly acting antiviral agents (DAAs). However, the development of an effective preventative vaccine would have a significant impact on HCV incidence and would represent a major advance towards controlling and possibly eradicating HCV globally. We previously reported a genotype 1a HCV viral-like particle (VLP) vaccine that produced neutralizing antibodies (NAb) and T cell responses to HCV. To advance this approach, we produced a quadrivalent genotype 1a/1b/2a/3a HCV VLP vaccine to produce broader immune responses...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691406/feed-forward-alpha-particle-radiotherapy-ablates-androgen-receptor-addicted-prostate-cancer
#18
Michael R McDevitt, Daniel L J Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S Abou, Philip A Watson, Bradley J Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S Lewis, Peter T Scardino, Howard I Scher, Hans Lilja, Steven M Larson, David Ulmert
Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-particle irradiation of PCa is prompted by molecularly specific-targeting and internalization of the humanized monoclonal antibody hu11B6 targeting hK2 and further accelerated by inherent DNA-repair that up-regulate hK2 (KLK2) expression in vivo...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691373/a-novel-sheet-like-virus-particle-array-is-a-hallmark-of-zika-virus-infection
#19
Jun Liu, Brandon A Kline, Tara A Kenny, Darci R Smith, Veronica Soloveva, Brett Beitzel, Song Pang, Stephen Lockett, Harald F Hess, Gustavo Palacios, Jens H Kuhn, Mei G Sun, Xiankun Zeng
Zika virus (ZIKV) is an emerging flavivirus that caused thousands of human infections in recent years. Compared to other human flaviviruses, ZIKV replication is not well understood. Using fluorescent, transmission electron, and focused ion beam-scanning electron microscopy, we examined ZIKV replication dynamics in Vero 76 cells and in the brains of infected laboratory mice. We observed the progressive development of a perinuclear flaviviral replication factory both in vitro and in vivo. In vitro, we illustrated the ZIKV lifecycle from particle cell entry to egress...
April 25, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29691268/stability-of-milrinone-in-continuous-ambulatory-delivery-devices
#20
Farah Al Madfai, Syed Tabish R Zaidi, Long Chiau Ming, Troy Wanandy, Rahul P Patel
PURPOSE: The stability of milrinone in continuous ambulatory delivery devices (CADDs) stored at 4, 25, and 35 °C was evaluated. METHOD: Six CADDs (3 devices containing milrinone plus 0.9% sodium chloride injection and 3 devices containing milrinone plus 5% dextrose injection) were prepared. Devices were kept at 4 °C for 168 hours, followed by 24 hours at 25 °C and an additional 24 hours at 35 °C. Samples ( n = 3) were withdrawn aseptically at 0, 24, 48, 72, 96, 120, 144, and 168 hours from the CADDs stored at 4 °C and at 0, 6, and 24 hours from the CADDs stored at 25 and 35 °C...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
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