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Bone marrow transplant surgery complications

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https://www.readbyqxmd.com/read/28469041/hepatosplenic-candidiasis-without-prior-documented-candidemia-an-underrecognized-diagnosis
#1
Joffrey van Prehn, C Willemien Menke-van der Houven van Oordt, Madelon L de Rooij, Ellen Meijer, Marije K Bomers, Karin van Dijk
INTRODUCTION: Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. In our experience, hepatosplenic candidiasis (HSC) without documented candidemia often remains unrecognized. CASE PRESENTATIONS: We describe three cases of HSC without documented candidemia and the challenges in establishing the diagnosis and adequately treating this condition. The first patient had a history of SCT for treatment of breast cancer and was scheduled for hemihepatectomy for suspected liver metastasis...
May 3, 2017: Oncologist
https://www.readbyqxmd.com/read/28407355/extracellular-vesicles-from-bone-marrow-derived-mesenchymal-stem-cells-protect-against-murine-hepatic-ischemia-reperfusion-injury
#2
Hiroaki Haga, Irene K Yan, David Borelli, Akiko Matsuda, Mansi Parasramka, Neha Shukla, David D Lee, Tushar Patel
Hepatic ischemia-reperfusion injury (IRI) and associated inflammation contributes to liver dysfunction and complications after liver surgery and transplantation. Mesenchymal stem cells (MSC) have been reported to reduce hepatic IRI because of their reparative immunomodulatory effects in injured tissues. Recent studies have highlighted beneficial effects of extracellular vesicles from MSCs (MSC-EV) on tissue injury. The effects of systemically administered mouse bone marrow derived MSC-EV were evaluated in an experimental murine model of hepatic IRI induced by cross clamping the hepatic artery and portal vein for 90 minutes followed by reperfusion for periods of upto 6 hours...
April 13, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28320105/anti-fibrotic-potential-of-human-umbilical-cord-mononuclear-cells-and-mouse-bone-marrow-cells-in-ccl4-induced-liver-fibrosis-in-mice
#3
Nageh Ahmed Elmahdy, Samia Salem Sokar, Mohamed Labib Salem, Naglaa Ibrahim Sarhan, Sherin Hamed Abou-Elela
Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic stellate cells (HSC). The treatment of choice is Liver transplantation; however, it has many problems such as surgery-related complications, immunological rejection and high costs associated with the procedure. Stem cell-based therapy would be a potential alternative, so the aim of this study is to investigate the therapeutic potential of human umbilical cord mononuclear cells (MNC) and mouse bone marrow cells (BMC) against carbon tetrachloride (CCl4) induced liver fibrosis in mice and compare it with that of silymarin...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28132518/stem-cell-treatment-in-crohn-s-disease
#4
Xiao-Mei Zhang, Yu-Jing Zhang, Wei Wang, Yu-Quan Wei, Hongxin Deng
Crohn's disease which mainly affects the gastrointestinal tract and impairs patient's quality of life, is a refractory inflammatory disease with clinical manifestations of abdominal pain, fever, bowel obstruction and diarrhoea with blood or mucus. Besides the common complication of intestinal obstruction, the formation of fistulas should also be concerned about and anorectal fistula is the most typical. The disease is difficult to radical cure and easy to relapse, which urges people to find other effective treatment in addition to surgery...
January 28, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28101148/cell-therapy-for-cerebral-hemorrhage-five-year-follow-up-report
#5
Zhitian Chang, Gengsheng Mao, Lizhong Sun, Qiang Ao, Yongquan Gu, Ying Liu
The aim of the study was to examine treatment of cerebral hemorrhages with bone-marrow or human umbilical cord-derived mesenchymal stem cells (BMSCs or Hu-MSCs) and conventional surgical approaches, and determine and compare the effectiveness, feasibility, safety and reproducibility of each method. A retrospective analysis was performed on a cohort of cell-treated cerebral hemorrhage patients from October 1, 2007 to October 1, 2009. A total of 24 patients, all of whom received conventional surgical treatment, were classified as follows: i) The control group consisted of 8 patients who received only hematoma removal surgery, ii) the autologous group consisted of 7 patients who received additional autologous bone marrow mononuclear cell transplantation, and iii) the allograft group consisted of 9 patients who received additional umbilical cord mononuclear cell transplantation...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27485733/-safety-and-utility-of-percutaneous-liver-biopsy-in-hematopoietic-stem-cell-transplant-pediatric-recipients-a-retrospective-study
#6
Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol, Aurelio Sonzogni
BACKGROUND: Liver biopsies in pediatric hematopoietic stem cell transplantation (HSCT) patients are as and effective when performed at bedside in the Bone Marrow Transplant Unit (BMTU) than in the Day Surgery Unit (DSU), with better patient compliance and lower emotional distress for these children. METHODS: The study group consisted of 45 children who underwent allogeneic HSCT. We reviewed 68 liver biopsies performed between April 2006 and September 2015. 12 (17...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27373389/cataract-surgery-in-patients-with-chronic-severe-graft-versus-host-disease
#7
Ankit Shah, Marcony R Santhiago, Edgar M Espana
PURPOSE: To evaluate the surgical outcomes of cataract extraction with phacoemulsification and intraocular lens implantation in patients with severe chronic ocular graft-versus-host disease (GVHD). SETTING: University of South Florida Eye Institute, Tampa, Florida, USA. DESIGN: Retrospective case study. METHODS: A chart review was performed to identify patients with clinically severe, biopsy-proven chronic ocular GVHD who had cataract extraction...
June 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27316391/bone-regeneration-strategies-with-bone-marrow-stromal-cells-in-orthopaedic-surgery
#8
REVIEW
J Stanovici, L-R Le Nail, M A Brennan, L Vidal, V Trichet, P Rosset, P Layrolle
Bone is the most transplanted tissue human with 1 million procedures every year in Europe. Surgical interventions for bone repair are required for varied reasons such as trauma resulting non-union fractures, or diseases including osteoporosis or osteonecrosis. Autologous bone grafting is the gold standard in bone regeneration but it requires a second surgery with associated pain and complications, and is also limited by harvested bone quantity. Synthetic bone substitutes lack the osteoinductive properties to heal large bone defects...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/26599503/autologous-mesenchymal-stem-cell-mscs-transplantation-for-critical-sized-bone-defect-following-a-wide-excision-of-osteofibrous-dysplasia
#9
Ismail Hadisoebroto Dilogo, Achmad Fauzi Kamal, Bambang Gunawan, Rangga Valentino Rawung
INTRODUCTION: Osteofibrous dysplasia is a rare non-neoplastic disease that is almost exclusive to pediatric tibial diaphysis. Wide excision of the lesion is recommended to avoid recurrence. However, such radical surgery will results in large segmental bone defects that will require further extensive reconstructive surgery. We report a novel approach of treating bone defect by implementing the diamond concept of bone healing using autologous bone marrow derived mesenchymal stem cells (BM-MSCs)...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26547402/hospital-costs-for-neonates-and-children-supported-with-extracorporeal-membrane-oxygenation
#10
David Faraoni, Viviane G Nasr, James A DiNardo, Ravi R Thiagarajan
OBJECTIVE: To assess the characteristics associated with high hospital cost for patients receiving extracorporeal membrane oxygenation (ECMO) to identify a cohort of high-resource users. STUDY DESIGN: Cost for hospitalization, during which ECMO support was used, was calculated from hospital charges reported in the 2012 Health Care Cost and Use Project Kid's Inpatient Database. Patients were categorized into 6 diagnostic groups: (1) cardiac surgery; (2) nonsurgical heart disease; (3) congenital diaphragmatic hernia; (4) neonatal respiratory failure; (5) pediatric respiratory failure; and (6) sepsis...
February 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26467140/evaluation-of-renal-function-in-pediatric-patients-after-treatment-for-wilms-tumor
#11
Małgorzata Janeczko, Ewa Niedzielska, Wojciech Pietras
BACKGROUND: Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre- and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their childhood is steadily growing, generating a need for long-term health assessment, including renal function, due to the specifications of the therapy and the location of the tumor. OBJECTIVES: The aim of the study was to evaluate nephrological complications after treatment for nephroblastoma...
May 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26244939/-s3-guideline-part-3-non-traumatic-avascular-necrosis-in-adults-surgical-treatment-of-atraumatic-avascular-femoral-head-necrosis-in-adults
#12
U Maus, A Roth, M Tingart, C Rader, M Jäger, U Nöth, S Reppenhagen, C Heiss, J Beckmann
The present article describes the guidelines for the surgical treatment of atraumatic avascular necrosis (aFKN). These include joint preserving and joint replacement procedures. As part of the targeted literature, 43 publications were included and evaluated to assess the surgical treatment. According to the GRADE and SIGN criteria level of evidence (LoE), grade of recommendation (EC) and expert consensus (EK) were listed for each statement and question. The analysed studies have shown that up to ARCO stage III, joint-preserving surgery can be performed...
October 2015: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/25857908/mechanisms-of-bone-marrow-derived-cell-therapy-in-ischemic-cardiomyopathy-with-left-ventricular-assist-device-bridge-to-transplant
#13
April Stempien-Otero, Deri Helterline, Tabitha Plummer, Stephen Farris, Andrew Prouse, Nayak Polissar, Derek Stanford, Nahush A Mokadam
BACKGROUND: Clinical trials report improvements in function and perfusion with direct injection of bone marrow cells into the hearts of patients with ischemic cardiomyopathy. Preclinical data suggest these cells improve vascular density, which would be expected to decrease fibrosis and inflammation. OBJECTIVES: The goal of this study was to test the hypothesis that bone marrow stem cells (CD34+) will improve histological measurements of vascularity, fibrosis, and inflammation in human subjects undergoing left ventricular assist device (LVAD) placement as a bridge to cardiac transplantation...
April 14, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25711909/a-novel-therapy-strategy-for-bile-duct-repair-using-tissue-engineering-technique-pcl-plga-bilayered-scaffold-with-hmscs
#14
Chen Zong, Meicong Wang, Fuchun Yang, Guojun Chen, Jiarong Chen, Zihua Tang, Quanwen Liu, Changyou Gao, Lie Ma, Jinfu Wang
The current clinical treatments for complications caused by hepatobiliary surgery still have some inevitable weakness. The aim of the study was to fabricate a tissue-engineered bile duct that utilized a novel bilayered polymer scaffold combined with human bone marrow-derived mesenchymal stem cells (hMSCs) for new treatment of biliary disease. The biocompatibility of polycaprolactone (PCL) (PCL)/poly(lactide-co-glycolide) (PLGA) scaffold with hMSCs was first examined, and the hMSC-PCL/PLGA constructs (MPPCs) prepared...
April 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/25574365/invasive-pulmonary-aspergillosis-in-a-haematopoietic-stem-cell-transplant-recipient-with-sickle-cell-disease-a-successful-treatment
#15
Katia Paciaroni, Gioia De Angelis, Cristiano Gallucci, Cecilia Alfieri, Michela Ribersani, Andrea Roveda, Antonella Isgrò, Marco Marziali, Ivan Pietro Aloi, Alessandro Inserra, Javid Gaziev, Pietro Sodani, Guido Lucarelli
Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach. Nevertheless the decision to perform a bone marrow transplant includes the risk of major complications and transplant-related mortality. Infections represent the leading cause of death in SCA patients undergoing HSCT. Invasive Pulmonary Aspergillosis (IPA) is a devastating opportunistic infection and remains a significant cause of morbidity and mortality in HSCT recipients...
2015: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/25557087/successful-three-year-outcome-in-a-patient-with-allogenous-sternal-bone-graft-in-the-treatment-of-massive-post-sternotomy-defects
#16
Martin Kaláb, Jan Karkoška, Milan Kamínek, Petr Šantavý
INTRODUCTION: Deep sternal wound infection is a life-threatening complication of longitudinal median sternotomy with extensive loss of sternal bone tissue and adjacent ribs. Wound dehiscence cases with no loss of bone tissue can be resolved via osteosynthesis using titanium plates. Unfortunately, this cannot be used in cases of massive bone tissue loss defects due to insufficient support for fixing the plate material caused by missing bone surface which increasing the risk of osteosynthesis failure...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/25334715/stereotactic-body-radiation-therapy-for-lung-metastases-in-a-child-with-ewing-sarcoma
#17
Mark Amsbaugh, Matthew Bertke, Alexandra Cheerva, Craig Silverman
Cancer Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Stereotactic Body Radiation Therapy (SBRT) delivers a high dose of radiation to a small volume over limited fractions. It is a viable treatment for localized lung cancer and oligometistatic pulmonary disease in adults, however, its role is not known in the pediatric population.CASE PRESENTATION: T.S. is a 14-year-old boy, diagnosed with Ewing's Sarcoma of the left acetabulum with pulmonary metastases...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25334680/azathioprine-induced-lymphoproliferative-disorder-in-dermatomyositis
#18
Saba Hamiduzzaman, Richard Moreahead
SESSION TITLE: Cancer Cases IISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Wednesday, October 29, 2014 at 11:00 AM - 12:15 PMINTRODUCTION: Patients with rheumatological diseases are at risk of developing lymphoproliferative disorders (LPD) with immunosuppression. LPD as a complication of azathioprine use in dermatomyositis has never been reported.CASE PRESENTATION: 67 year old woman with a history of dermatomyositis presented with complaints of fatigue, weight loss, and fever...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25332936/tendon-to-bone-healing-using-autologous-bone-marrow-derived-mesenchymal-stem-cells-in-acl-reconstruction-without-a-tibial-bone-tunnel-a-histological-study
#19
Tomonoshin Kanazawa, Takashi Soejima, Kouji Noguchi, Kousuke Tabuchi, Megumi Noyama, Kei-Ichiro Nakamura, Naoto Shiba
BACKGROUND: after anterior cruciate ligament (ACL) reconstruction, it is necessary to integrate free tendon graft biologically to the bone. In the present study, to verify whether a structure identical to the normal ligament-bone insertion could be regenerated at the tendon-bone interface without bone tunnel, we designed ACL reconstruction model without a tibial bone tunnel. Moreover, to enhance the integration process in this model, bone marrow-derived mesenchymal stem cells (bMSCs) were transplanted, and histological changes investigated...
April 2014: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/25281762/transplantation-of-bone-marrow-stem-cells-during-cardiac-surgery
#20
REVIEW
Sadegh Ali-Hassan-Sayegh, Seyed Jalil Mirhosseini, Mohammad-Reza Lotfaliani, Hamid Reza Dehghan, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Mohammad Rezaeisadrabadi, Naser Ghaffari, Vahid Vahabzadeh, Ahamd Fawad Jebran, Anton Sabashnikov, Aron-Frederik Popov
BACKGROUND: This systematic review with meta-analysis sought to determine the efficacy and safety of intramyocardial transplantation of bone marrow stem cells during coronary artery bypass graft surgery on postoperative cardiac functional parameters such as left ventricular ejection fraction and left ventricular end-diastolic volume. METHODS: Medline/PubMed, Embase, Elsevier, Sciences online database, and Google Scholar literature search were searched. The effect sizes measured were risk ratio for categorical variables and weighted mean difference with 95% confidence interval for calculating differences between mean values of baseline and follow-up cardiac functional parameters...
March 2015: Asian Cardiovascular & Thoracic Annals
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