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Surgical complications bone marrow transplant

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https://www.readbyqxmd.com/read/29099537/use-of-peripherally-inserted-central-venous-catheters-piccs-in-children-receiving-autologous-or-allogeneic-stem-cell-transplantation
#1
Stefano Benvenuti, Rosanna Ceresoli, Giovanni Boroni, Filippo Parolini, Fulvio Porta, Daniele Alberti
INTRODUCTION: The aim of our study was to present our experience with the use of peripherally inserted central catheters (PICCs) in pediatric patients receiving autologous or allogenic blood stem-cell transplantation. The insertion of the device in older children does not require general anesthesia and does not require a surgical procedure. METHODS: From January 2014 to January 2017, 13 PICCs were inserted as a central venous device in 11 pediatric patients submitted to 14 autologous or allogeneic stem-cell transplantation, at the Bone Marrow Transplant Unit of the Children's Hospital of Brescia...
October 31, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28899741/small-bowel-stenosis-a-manifestation-of-chronic-graft-versus-host-disease-in-children
#2
Mickael Tordjman, Marie Ouachee, Arnaud Bonnard, Bogdana Tilea, Karima Yakouben, Jerome Viala, Michel Peuchmaur, Dominique Berrebi
Digestive graft versus host disease (GVHD) is a frequent complication after bone marrow transplantation (BMT), but small bowel obstruction is an extremely rare event. We present herein the first pediatric series of 4 cases of small bowel obstruction after BMT with detailed gross, histological data and their genetic status of the NOD2 gene. All patients had a history of severe acute GVHD treated by immunosuppressive agents and/or infliximab (in 3 cases). Acute or progressively worsening abdominal pain accompanied by small bowel occlusion occurred 5-16months after graft and CT-scan revealed multiple small intestinal stenosis...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28871936/xanthoma-like-skin-changes-in-an-elderly-woman-with-a-normal-lipid-profile
#3
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28806822/-multiple-myeloma-current-status-in-diagnostic-testing-and-therapy
#4
Michael Kehrer, Sebastian Koob, Andreas Strauss, Dieter Christian Wirtz, Jan Schmolders
Background Multiple myeloma is a haematological blood cancer of the bone marrow and is classified by the World Health Organisation (WHO) as a plasma cell neoplasm. In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of an abnormal immunoglobulin called monoclonal protein or M protein. This ultimately causes multiple myeloma symptoms such as bone damage or kidney problems. The annual worldwide incidence of multiple myeloma is estimated to be 6 - 7/100,000 and accounts for 1% of all cancer...
October 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28767907/retinal-changes-in-solid-organ-and-bone-marrow-transplantation-patients
#5
Fernando Korn Malerbi, Sergio Henrique Teixeira, Luis Gustavo Gondo Hirai, Nilson Hideo Matsudo, Adriano Biondi Monteiro Carneiro
Objective: To evaluate retinal changes in patients who underwent solid organ or bone marrow transplantation. Methods: A retrospective analysis of medical records of patients evaluated from February 2009 to December 2016. All patients included underwent funduscopy. Clinical and demographic data regarding transplantation and ophthalmological changes were collected. Results: A total of 126 patients were analyzed; of these, 108 underwent transplantation and 18 were in the waiting list...
April 2017: Einstein
https://www.readbyqxmd.com/read/28390107/posttransplant-lymphoproliferative-disorder-after-clinical-islet-transplantation-report-of-the-first-two-cases
#6
A Peters, T Olateju, J Deschenes, S H Shankarnarayan, N Chua, A M J Shapiro, P Senior
We report the first two cases of posttransplant lymphoproliferative disorder (PTLD) in recipients of islet transplants worldwide. First, a 44-year-old recipient of three islet infusions developed PTLD 80 months after his initial transplantation, presenting with abdominal pain and diffuse terminal ileum thickening on imaging. He was treated with surgical excision, reduction of immunosuppression, and rituximab. Seven months later, he developed central nervous system PTLD, presenting with vertigo and diplopia; immunosuppression was discontinued, resulting in graft loss, and he was given high-dose methotrexate and underwent consolidative autologous stem cell transplantation...
September 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28297787/-umbilical-cord-mesenchymal-stem-cells-and-their-association-with-liver-fibrosis
#7
REVIEW
L Tuo, W Z Zeng, H L Xue, X L Wu
At present, the most effective therapeutic method for end-stage liver fibrosis is liver transplantation. However, the application of liver transplantation is limited by a shortage of liver donors, a high incidence rate of surgical complications, graft-versus-host disease, and high medical costs. Umbilical cord mesenchymal stem cell (UC-MSC) transplantation may become a promising method for the treatment of liver diseases. UC-MSCs are adult stem cells which exhibit multipotential differentiation and can differentiate into hepatic parenchymal cells...
January 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28101148/cell-therapy-for-cerebral-hemorrhage-five-year-follow-up-report
#8
Zhitian Chang, Gengsheng Mao, Lizhong Sun, Qiang Ao, Yongquan Gu, Ying Liu
The aim of the study was to examine treatment of cerebral hemorrhages with bone-marrow or human umbilical cord-derived mesenchymal stem cells (BMSCs or Hu-MSCs) and conventional surgical approaches, and determine and compare the effectiveness, feasibility, safety and reproducibility of each method. A retrospective analysis was performed on a cohort of cell-treated cerebral hemorrhage patients from October 1, 2007 to October 1, 2009. A total of 24 patients, all of whom received conventional surgical treatment, were classified as follows: i) The control group consisted of 8 patients who received only hematoma removal surgery, ii) the autologous group consisted of 7 patients who received additional autologous bone marrow mononuclear cell transplantation, and iii) the allograft group consisted of 9 patients who received additional umbilical cord mononuclear cell transplantation...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27373389/cataract-surgery-in-patients-with-chronic-severe-graft-versus-host-disease
#9
Ankit Shah, Marcony R Santhiago, Edgar M Espana
PURPOSE: To evaluate the surgical outcomes of cataract extraction with phacoemulsification and intraocular lens implantation in patients with severe chronic ocular graft-versus-host disease (GVHD). SETTING: University of South Florida Eye Institute, Tampa, Florida, USA. DESIGN: Retrospective case study. METHODS: A chart review was performed to identify patients with clinically severe, biopsy-proven chronic ocular GVHD who had cataract extraction...
June 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27355149/long-term-outcome-of-intra-myocardial-injection-of-autologous-bone-marrow-mononuclear-cells-combined-with-isolated-coronary-artery-bypass-grafting-for-patients-with-chronic-ischemic-heart-failure
#10
RANDOMIZED CONTROLLED TRIAL
Rong Wang, Lin Zhang, Yao Wang, Zhiyun Gong, Cangsong Xiao, Yang Wu, Chonglei Ren, Nan Cheng, Changqing Gao
OBJECTIVE: This study aimed to investigate whether intra-myocardial injection of autologous bone marrow mononuclear cells (aBMMNCs) into peri-scarred myocardium during coronary artery bypass grafting (CABG) improved the long-term outcome compared with CABG alone. METHODS: From April 2011 to December 2012, 33 patients with chronic ischemic heart failure were randomly assigned to undergo CABG (control group) or CABG combined with intra-myocardial injection of aBMMNCs (treatment group)...
June 24, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27316391/bone-regeneration-strategies-with-bone-marrow-stromal-cells-in-orthopaedic-surgery
#11
REVIEW
J Stanovici, L-R Le Nail, M A Brennan, L Vidal, V Trichet, P Rosset, P Layrolle
Bone is the most transplanted tissue human with 1 million procedures every year in Europe. Surgical interventions for bone repair are required for varied reasons such as trauma resulting non-union fractures, or diseases including osteoporosis or osteonecrosis. Autologous bone grafting is the gold standard in bone regeneration but it requires a second surgery with associated pain and complications, and is also limited by harvested bone quantity. Synthetic bone substitutes lack the osteoinductive properties to heal large bone defects...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27312041/pleuroparenchymal-fibroelastosis-after-allogenic-hematopoietic-stem-cell-transplantation-important-histological-component-of-late-onset-noninfectious-pulmonary-complication-accompanied-with-recurrent-pneumothorax
#12
Takahiro Matsui, Tetsuo Maeda, Toru Kida, Jiro Fujita, Hiromi Tsuji, Eiichi Morii, Yuzuru Kanakura
Late-onset noninfectious pulmonary complication after allogenic hematopoietic stem cell transplantation is an important contributing factor associated with high rate morbidity and mortality. We report a case with pleuroparenchymal fibroelastosis (PPFE) occurred after allogenic bone marrow transplantation. The onset was infiltrative shadows in upper lobes, and the haziness spread gradually throughout the lungs with recurrent episodes of pneumothorax in both lungs. Progressive respiratory failure in course of adrenocortical steroid administration eventually caused death...
October 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/26821761/management-of-inflammatory-corneal-melt-leading-to-central-perforation-in-children-a-retrospective-study-and-review-of-literature
#13
REVIEW
A Medsinge, E Gajdosova, W Moore, K K Nischal
PURPOSE: To assess the outcome of early therapeutic penetrating keratoplasty (PKP) for corneal melt leading to perforation in children. METHODS: Case notes of all the consecutive patients presenting with acute corneal perforation that underwent urgent therapeutic PKP between 2000 and 2010 to the practice of one of the authors, both NHS at Great Ormond Street Hospital for Children and private, were retrospectively reviewed. Onset of perforation, underlying cause, medical and surgical treatment, pre- and post-operative visual acuity, graft clarity, length of follow-up, and post-operative complications were recorded...
April 2016: Eye
https://www.readbyqxmd.com/read/26605555/cell-therapy-for-bone-nonunion-a-retrospective-study
#14
COMPARATIVE STUDY
Z Qu, G Fang, Z Cui, Y Liu
AIM: The aim of this study was to report our experience in augmenting nonunion both with bone marrow mononuclear cells/mesenchymal stem cells (MSCs) and conventional surgical approaches; and for clinical applications, a simple, safe, and reproducible method to effectively treat bone mass loss disease. METHODS: A retrospective analysis was performed on stem cell-treated bone nonunion patients from October 1, 2007 to October 1, 2009. Nine patients were categorized into two groups: group 1 consists of 3 patients who received autologous bone marrow mononuclear cells transplantation; group 2 consists of 6 patients who received umbilical cord MSCs (hUC-MSCs) transplantation...
December 2015: Minerva Medica
https://www.readbyqxmd.com/read/26581487/a-de-novo-whole-gene-deletion-of-xiap-detected-by-exome-sequencing-analysis-in-very-early-onset-inflammatory-bowel-disease-a-case-report
#15
Judith R Kelsen, Noor Dawany, Alejandro Martinez, Alejuandro Martinez, Christopher M Grochowski, Kelly Maurer, Eric Rappaport, David A Piccoli, Robert N Baldassano, Petar Mamula, Kathleen E Sullivan, Marcella Devoto
BACKGROUND: Children with very early-onset inflammatory bowel disease (VEO-IBD), those diagnosed at less than 5 years of age, are a unique population. A subset of these patients present with a distinct phenotype and more severe disease than older children and adults. Host genetics is thought to play a more prominent role in this young population, and monogenic defects in genes related to primary immunodeficiencies are responsible for the disease in a small subset of patients with VEO-IBD...
November 18, 2015: BMC Gastroenterology
https://www.readbyqxmd.com/read/26380141/pleuroparenchymal-fibroelastosis-a-new-entity-within-the-spectrum-of-rare-idiopathic-interstitial-pneumonias
#16
Karina Portillo, Ignasi Guasch, Caroline Becker, Felipe Andreo, Maria Teresa Fernández-Figueras, José Ramirez Ruz, Carlos Martinez-Barenys, Samuel García-Reina, Pedro Lopez de Castro, Irene Sansano, Ana Villar, Juan Ruiz-Manzano
Pleuroparenchymal fibroelastosis (PPFE) is a rare entity that has been recently included in the official American Thoracic Society/European Respiratory Society (ATS/ERS) statement in 2013 as a group of rare idiopathic interstitial pneumonias (IIPs). PPFE is characterized by pleural and subpleural parenchymal thickening due to elastic fiber proliferation, mainly in the upper lobes. The etiology of the disease is unclear, although some cases have been associated as a complication after bone marrow transplantation, lung transplantation (LT), chemotherapy, and recurrent respiratory infections...
2015: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/26285106/post-transplant-lymphoproliferative-disorder-ptld-manifesting-in-the-oral-cavity-of-a-13-year-old-liver-transplant-recipient-ltx
#17
Ewa Krasuska-Sławińska, Izabela Minko-Chojnowska, Joanna Pawłowska, Bożenna Dembowska-Bagińska, Maciej Pronicki, Dorota Olczak-Kowalczyk
BACKGROUND Post-transplant lymphoproliferative disorder (PTLD) is a potential complication of solid organ or bone marrow transplants. The main PTLD risk factors are: the Epstein-Barr virus (EBV), transplant type, and use of immunosuppressants. It mainly consists of an uncontrolled growth of lymphocytes in transplant recipients under chronic immunosuppressive therapy. About 85% of PTLDs are EBV-containing B-cell proliferations; 14% are T-cell proliferations, of which only 40% contain EBV; and the remaining 1% is NK-cell or plasmocyte proliferations...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/26244939/-s3-guideline-part-3-non-traumatic-avascular-necrosis-in-adults-surgical-treatment-of-atraumatic-avascular-femoral-head-necrosis-in-adults
#18
U Maus, A Roth, M Tingart, C Rader, M Jäger, U Nöth, S Reppenhagen, C Heiss, J Beckmann
The present article describes the guidelines for the surgical treatment of atraumatic avascular necrosis (aFKN). These include joint preserving and joint replacement procedures. As part of the targeted literature, 43 publications were included and evaluated to assess the surgical treatment. According to the GRADE and SIGN criteria level of evidence (LoE), grade of recommendation (EC) and expert consensus (EK) were listed for each statement and question. The analysed studies have shown that up to ARCO stage III, joint-preserving surgery can be performed...
October 2015: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/26030048/tandem-high-dose-chemotherapy-strategy-as-first-line-treatment-of-primary-disseminated-multifocal-ewing-sarcomas-in-children-adolescents-and-young-adults
#19
S Loschi, C Dufour, O Oberlin, G Goma, D Valteau-Couanet, N Gaspar
The prognosis of primary disseminated multifocal metastatic Ewing's sarcoma (PDMES) is poor even if a slight improvement has been achieved with high-dose alkylating agent-containing chemotherapy. To enhance treatment efficacy, we assessed the feasibility, safety and efficacy of a tandem high-dose chemotherapy (HDC) regimen. In a single institution, patients with PDMES received six courses of vincristine/ifosfamide/doxorubicin/etoposide induction therapy, followed by high-dose thiotepa, and then melphalan-busulfan, 8 weeks apart...
August 2015: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/25957864/factors-that-increase-diagnostic-yield-of-surgical-lung-biopsy-in-pediatric-oncology-patients
#20
Shannon N Acker, Danielle Gonzales, James T Ross, Megan K Dishop, Robin R Deterding, David A Partrick
PURPOSE: Recent data demonstrate that surgical lung biopsy in immunocompromised children, including oncology patients, alters therapy in only 50% of cases. We hypothesized that there are factors identifiable preoperatively which can predict the patients who will or will not benefit from surgical biopsy. METHODS: We reviewed the medical records of all children with malignancy who underwent surgical lung biopsy between 2004 and 2013 at a single institution, excluding those children who had previously undergone a solid organ or bone marrow transplant...
September 2015: Journal of Pediatric Surgery
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