keyword
MENU ▼
Read by QxMD icon Read
search

ocriplasmin

keyword
https://www.readbyqxmd.com/read/28427074/enzymatic-vitreolysis-for-vitreomacular-traction-in-diabetic-retinopathy
#1
Stanislao Rizzo, Daniela Bacherini
Vitreomacular traction (VMT) is one of many possible factors involved in the etiology of diabetic macular edema (DME). Pharmacologic vitreoretinal separation is a potential alternative to vitrectomy for VMT in diabetic retinopathy. Small case series have been published on the use of enzymatic vitreolysis in tractional DME, and demonstrate that the enzymatic release of the posterior vitreous cortex is more likely following the injection of plasmin enzyme. Further prospective and randomized clinical trials are necessary to evaluate the clinical relevance of ocriplasmin for vitreomacular traction in diabetic retinopathy, and additional studies are needed to determine more accurately which patients might benefit most from this treatment and how often and at what concentration ocriplasmin should be administered...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28389700/the-predictability-of-ocriplasmin-treatment-effects-is-there-consensus-among-retinal-experts-results-from-the-export-study
#2
Thomas Bertelmann, Joachim Wachtlin, Stefan Mennel, Michael J Koss, Mathias M Maier, Ricarda G Schumann, Sara Kazerounian, Hanna Daniel, Steffen Schmitz-Valckenberg
PURPOSE: To evaluate the agreement and predictability of ocriplasmin treatment effects among retinal experts (raters) by assessment of retinal imaging data of eyes treated for vitreomacular traction in nine different centers in Germany and Austria. METHODS: Retrospective cohort study. Combined confocal near-infrared scanning laser ophthalmoscopy and spectral-domain optical coherence tomography images (Spectralis® device, Heidelberg Engineering GmbH, Germany) from 136 eyes of 135 subjects were reviewed by 14 raters using an internet-based grading database and a standardized questionnaire...
April 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28282697/-initial-clinical-experiences-using-ocriplasmin-for-the-treatment-of-vitreomacular-traction-with-or-without-a-macular-hole
#3
J Lenk, E Matthé, S Ventzke, L E Pillunat, D Sandner
Purpose In vitreomacular traction (VMT), there is abnormal adhesion between the vitreous cortex and the retina, especially in the fovea. Symptoms of VMT include metamorphopsia and a decrease in visual acuity. Since 2013, ocriplasmin (Jetrea®) has been approved for treatment of symptomatic vitreomacular traction with or without macular holes (≤ 400 µm). Methods We retrospectively examined twenty-three eyes of twenty-one patients who underwent intravitreal ocriplasmin treatment for symptomatic vitreomacular traction with or without macular holes...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28282694/long-term-persistence-of-subfoveal-fluid-following-ocriplasmin-treatment-of-an-ftmh
#4
S Tschuppert, H Gerding
No abstract text is available yet for this article.
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28264098/intravitreally-injected-fluid-dispersion-importance-of-injection-technique
#5
Koen Willekens, Geert Reyns, Marjan Diricx, Marc Vanhove, Bernard Noppen, Walter Coudyzer, Yicheng Ni, Jean H M Feyen, Peter Stalmans
Purpose: The purpose of this study was to evaluate the dispersion of intravitreally injected solutions and investigate the influence of varying injection techniques. Methods: This was a prospective study using enucleated porcine eyes and ultra-high-resolution computed tomography (UHRCT) scanning to visualize iomeprol intravitreal dispersion. Sixty eyes were divided over 12 different groups according to the injection procedure: fast (2 seconds) or slow (10 seconds) injection speed and needle tip location (6- and 12-mm needle shaft insertion or premacular tip placement verified by indirect ophthalmoscopy)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28198785/evaluation-of-full-field-electroretinogram-reductions-after-ocriplasmin-treatment-results-of-the-oasis-trial-erg-substudy
#6
David G Birch, Matthew S Benz, Daniel M Miller, Andrew N Antoszyk, Joseph Markoff, Petra Kozma, Esmeralda Meunier, Robert C Sergott
PURPOSE: To explore a possible association between full-field electroretinograms with vitreomacular adhesion resolution and best-corrected visual acuity as part of the prospective, randomized, double-masked, sham-controlled Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole (OASIS) trial studying ocriplasmin. METHODS: The ERG substudy enrolled 62 of 220 OASIS subjects (randomized 2:1) and analyzed full-field electroretinograms and their association with both vitreomacular adhesion resolution and best-corrected visual acuity from baseline through Month 24...
February 14, 2017: Retina
https://www.readbyqxmd.com/read/28133919/visual-function-response-to-ocriplasmin-for-the-treatment-of-vitreomacular-traction-and-macular-hole
#7
Timothy L Jackson, Thomas Verstraeten, Luc Duchateau, Benedicte Lescrauwaet
PURPOSE: To assess the effect of an intravitreal ocriplasmin injection on visual function, measured using visual acuity (VA) and vision-related quality of life. METHODS: Post hoc analysis of prespecified secondary end-points in two multicentre, randomized, double-masked, phase 3 clinical trials. A total of 652 participants with symptomatic vitreomacular adhesion were enrolled, of whom 464 received a single intravitreal injection of 125 μg ocriplasmin and 188 received a single intravitreal placebo injection...
January 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28106706/intravitreal-ocriplasmin-in-clinical-practice-predictors-of-success-visual-outcomes-and-complications
#8
Henry L Feng, Daniel B Roth, Aisha Hasan, Howard F Fine, H Matthew Wheatley, Jonathan L Prenner, Sumit P Shah, Kunjal K Modi, William J Feuer
PURPOSE: To investigate predictors of success, visual outcomes, and complications of intravitreal ocriplasmin for the treatment of symptomatic vitreomacular adhesion in a clinical care setting. METHODS: Retrospective chart review of 49 consecutive eyes of 47 patients who received intravitreal ocriplasmin. Spectral domain optical coherence tomography scans were examined for vitreomacular traction (VMT) release, full-thickness macular hole (FTMH) closure, and other changes in retinal anatomy...
January 18, 2017: Retina
https://www.readbyqxmd.com/read/28098729/vitrectomy-for-persistent-macular-holes-following-ocriplasmin-injection-a-comparative-multicenter-study
#9
Ricarda G Schumann, Armin Wolf, Hans Hoerauf, Albrecht Lommatzsch, Mathias Maier, Joachim Wachtlin, Michael J Koss, Thomas Kreutzer, Thomas Bertelmann, Sara Kazerounian, Stefan Mennel, Siegfried G Priglinger
PURPOSE: To determine functional and anatomical outcomes of pars plana vitrectomy for persistent full-thickness macular hole (MH) after intravitreal injection of ocriplasmin. METHODS: This is a multicenter retrospective interventional study of 37 eyes of 37 patients who underwent pars plana vitrectomy with internal limiting membrane peeling for persistent MH after ocriplasmin treatment between December 2013 and December 2015 and comparison with 35 eyes of 35 patients who were offered ocriplasmin injection but underwent pars plana vitrectomy alone without pharmacologic vitreolysis before surgery...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28033236/longitudinal-microperimetry-evaluation-after-intravitreal-ocriplasmin-injection-for-vitreomacular-traction
#10
Andrea Cacciamani, Aldo Gelso, Joseph M Simonett, Guido Ripandelli, Marco Pileri, Mario Stirpe, Fabio Scarinci
PURPOSE: To determine whether improvements in microperimetry testing are associated with anatomic resolution after ocriplasmin treatment in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction and relatively preserved baseline best-corrected visual acuity (BCVA). METHODS: Patients with vitreomacular traction received a single 125-μg intravitreal ocriplasmin injection and were followed longitudinally for 6 months with optical coherence tomography, BCVA testing, and microperimetry...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28005718/proportion-of-patients-with-macular-hole-surgery-who-would-have-been-favorable-ocriplasmin-candidates-a-retrospective-analysis
#11
Khurram Chaudhary, Michael Y K Mak, Robert Gizicki, Rajeev H Muni, David T Wong, Filiberto Altomare, Alan R Berger
PURPOSE: To identify favorable ocriplasmin candidates from a cohort of idiopathic full thickness macular hole surgery patients. METHODS: The records of patients with full thickness macular hole who underwent pars plana vitrectomy surgery between 2011 and 2015 were reviewed. Clinical data collected included patient demographics, pre- and post-operative Snellen visual acuity, optical coherence tomography findings, and lens status. The authors defined "favorable" ocriplasmin candidates as patients with focal vitreomacular traction, no epiretinal membrane, and hole size ≤400 μm...
January 2017: Retina
https://www.readbyqxmd.com/read/27990054/ocriplasmin-for-vitreomacular-traction
#12
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Australian Prescriber
https://www.readbyqxmd.com/read/27971643/long-term-visual-functioning-improvement-is-associated-with-resolution-of-vitreomacular-adhesion-in-subjects-with-vitreomacular-traction-including-macular-hole-treated-with-intravitreal-ocriplasmin-results-from-the-oasis-study
#13
B Lescrauwaet, L Duchateau, T Verstraeten, T L Jackson
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27913441/size-and-vitreomacular-attachment-of-primary-full-thickness-macular-holes
#14
Elise Philippakis, Franck Amouyal, Aude Couturier, Elise Boulanger-Scemama, Alain Gaudric, Ramin Tadayoni
PURPOSE: To study the relationship between the size of primary full-thickness macular hole (MH) and the vitreomacular attachment status. DESIGN: Single-centre retrospective observational case series. METHODS: The records of 100 consecutive eyes operated for primary full-thickness MH were retrospectively reviewed. The vitreous status and MH diameter were assessed on the preoperative optical coherence tomography scans. MH were classified depending on the presence or absence of vitreomacular traction (VMT) and their size as small (<250 µm), medium (250-400 µm) and large (>400 µm), as suggested in the International VMT Study Group Classification...
December 2, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27787446/impact-of-vitreoretinal-interface-architecture-on-successful-vitreomacular-traction-resolution-in-eyes-scheduled-for-intravitreal-ocriplasmin-therapy
#15
Christoph Paul, Christine Heun, Hans H Müller, Sascha Fauser, Hakan Kaymak, Sara Kazerounian, Walter Sekundo, Stefan Mennel, Carsten H Meyer, Steffen Schmitz-Valckenberg, Michael J Koss, Nicolas Feltgen, Thomas Bertelmann
PURPOSE: To evaluate the impact of the vitreoretinal interface architecture, in specific the angle between the posterior vitreous cortex and the internal limiting membrane, on vitreomacular traction (VMT) resolution in eyes treated with intravitreally injected ocriplasmin (Jetrea). METHODS: Retrospective, multicenter cohort study and exploratory data analysis. Spectral domain optical coherence tomography assessments were performed before scheduled ocriplasmin injections...
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27786583/the-efficacy-and-safety-profile-of-ocriplasmin-in-vitreomacular-interface-disorders
#16
REVIEW
Mehrine Shaikh, John B Miller, Thanos D Papakostas, Deeba Husain
Vitreomacular adhesion (VMA) describes the adhesion of the posterior hyaloid face to the inner retina in any part of the macula. This can arise after incomplete separation of the posterior vitreous cortex from the macula during vitreous liquefaction. While the VMA may resolve spontaneously, a strong and persistent adhesion can lead to a variety of anatomical changes, including vitreomacular traction (VMT) and macular hole (MH). Both conditions can present with metamorphopsia and decreased vision. In cases of symptomatic VMT and full-thickness macular hole, pars plana vitrectomy has long been the standard of care...
2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27779685/identification-of-potential-biomarkers-and-drugs-for-papillary-thyroid-cancer-based-on-gene-expression-profile-analysis
#17
Ting Qu, Yan-Ping Li, Xiao-Hong Li, Yan Chen
The present study aimed to systematically examine the molecular mechanisms of papillary thyroid cancer (PTC), and identify potential biomarkers and drugs for the treatment of PTC. Two microarray data sets (GSE3467 and GSE3678), containing 16 PTC samples and 16 paired normal samples, were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified using the Linear Models for Microarray Analysis package. Subsequently, the common DEGs were screened for functional and pathway enrichment analysis using the Database for Annotation Visualization and Integrated Discovery...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27688592/release-of-experimental-retinal-vein-occlusions-by-direct-intraluminal-injection-of-ocriplasmin
#18
Marc D de Smet, Jean Marie Stassen, Thijs C M Meenink, Tom Janssens, Valérie Vanheukelom, Gerrit J L Naus, Maarten J Beelen, Bart Jonckx
PURPOSE: Retinal vein occlusions (RVO) are a major cause of vision loss in people aged 50 years and older. Current therapeutic options limit the consequences of RVO but do not eliminate the cause. Cannulation of the involved vessel and removal of the clot may provide a more permanent solution with a less demanding follow-up. However, cannulation of smaller retinal veins remains challenging. This paper explores the use of ocriplasmin (recombinant plasmin without its kringles) to clear RVO, using a robotic micromanipulator...
December 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27681001/treatment-of-vitreomacular-traction-with-intravitreal-perfluoropropane-c3f8-injection
#19
Nathan C Steinle, Dilsher S Dhoot, Carlos Quezada Ruiz, Alessandro A Castellarin, Dante J Pieramici, Robert F See, Steven C Couvillion, Maʼan A Nasir, Robert L Avery
PURPOSE: To assess the posterior vitreous release rates following a single, office-based intravitreal injection of expansile gas in treating vitreomacular traction. METHODS: Thirty eyes of 29 consecutive patients with symptomatic vitreomacular traction received a single, office-based intravitreal injection of up to 0.3 mL of 100% perfluoropropane (C3F8). RESULTS: Overall, vitreomacular traction release occurred in 25 of 30 eyes by the final follow-up visit (83% final release rate); furthermore, 90% (9 of 10 eyes) with diabetes mellitus released, 83% (5 of 6 eyes) with concurrent epiretinal membrane released, and 83% (5 of 6 eyes) previously treated with ocriplasmin released...
April 2017: Retina
https://www.readbyqxmd.com/read/27619226/ocriplasmin-for-treatment-of-vitreomacular-traction-an-update
#20
REVIEW
Mohammed Ali Khan, Julia A Haller
Pharmacologic vitreolysis with ocriplasmin, a 27 kilodalton serine protease, is an effective nonsurgical treatment option for vitreomacular traction (VMT). Data from phase III clinical studies, including the Microplasmin for Intravitreal Injection-Traction Release without Surgical Treatment (MIVI-TRUST) and Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole (OASIS) studies, have demonstrated the treatment efficacy of ocriplasmin for VMT and full-thickness macular hole (FTMH)...
December 2016: Ophthalmology and Therapy
keyword
keyword
55513
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"