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https://www.readbyqxmd.com/read/29029053/a-12-year-follow-up-on-the-long-term-effectiveness-of-the-quadrivalent-human-papillomavirus-vaccine-in-4-nordic-countries
#1
Susanne K Kjaer, Mari Nygård, Joakim Dillner, J Brooke Marshall, David Radley, Meng Li, Christian Munk, Bo T Hansen, Lara G Sigurdardottir, Maria Hortlund, Laufey Tryggvadottir, Amita Joshi, Rituparna Das, Alfred J Saah
Background: The long-term effectiveness of the quadrivalent human papillomavirus (qHPV) vaccine was assessed by monitoring the combined incidence of cervical intraepithelial neoplasia (CIN2, CIN3), adenocarcinoma in situ (AIS), and cervical cancer related to HPV16 or HPV18. Methods: Women from Nordic countries of Denmark, Iceland, Norway, and Sweden who received a 3-dose regimen of the qHPV vaccine in the beginning of FUTURE II (Females United to Unilaterally Reduce Endo/Ectocervical Disease; V501-015, base study NCT00092534) are followed through different national registries...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028665/gynecologic-cancer-in-hiv-infected-women-treatment-and-outcomes-in-a-multi-institutional-cohort
#2
Kimberly L Levinson, David J Riedel, Laureen S Ojalvo, Wesley Chan, Ana M Azngarita, Amanda N Fader, Anne F Rositch
OBJECTIVE: To evaluate gynecologic cancer treatments in Human Immunodeficiency Virus (HIV) infected women for adherence to National Comprehensive Cancer Network (NCCN) guidelines and to describe survival by adherence to guidelines. DESIGN: Beyond cervical cancer, there is little data on treatment and outcomes for these women. This is a retrospective cohort study of HIV infected women with gynecologic cancers. METHODS: HIV infected women with gynecologic cancers from 2000-2015 were identified at two urban, comprehensive cancer centers...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29027811/prevention-of-human-papillomavirus-hpv-related-tumors-in-people-living-with-human-immunodeficiency-virus-hiv
#3
Mario Poljak, Anja Šterbenc, Maja M Lunar
In comparison to their HIV-negative counterparts, people living with HIV (PLWH) have a higher prevalence of human papillomavirus (HPV) infection in various anatomical sites coupled with increased HPV persistence, higher risk of HPV-related tumors, and faster disease progression. Areas covered: Gender-neutral prevention strategies for HPV-related cancers in PLWH discussed: ABC approach, HPV vaccination, antiretroviral treatment (ART), anal cancer screening, and smoking cessation. Gender specific strategies: cervical cancer screening reduces the incidence and mortality of cervical cancer and circumcision might reduce the risk of HPV infections in men...
October 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29027676/toxicokinetics-of-strychnine-and-brucine-after-the-oral-administration-of-biqi-capsule-to-rats-by-rrlc-ms-ms
#4
Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang
Biqi capsule is a well-known traditional Chinese medicine (TCM) formula that has been widely applied for the clinical treatment of such diseases as rheumatoid arthritis, scapulohumeral periarthritis, and cervical spondylopathy. However, there is concern regarding the toxicity of Biqi capsule due to its active ingredients, strychnine and brucine. To investigate the toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats, a sensitive and simple rapid-resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS) method was developed to determine the levels of strychnine and brucine in rat plasma...
October 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29027399/early-stage-node-negative-cervical-adenocarcinoma-and-squamous-cell-carcinoma-show-similar-survival-outcomes-after-hysterectomy-a-population-based-study
#5
San Gang Wu, Jia Yuan Sun, Zhen Yu He, Qiong Hua Chen, Juan Zhou
OBJECTIVE: To investigate the clinicopathological features and outcomes between node-negative, early-stage cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) after hysterectomy. METHODS: Patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stages I-IIA cervical SCC and AC between 1988 and 2013 were retrospectively reviewed using the Surveillance, Epidemiology, and End Results database. We used propensity score-matching to balance patient baseline characteristics...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027397/comparing-treatment-outcomes-of-stage-iiib-cervical-cancer-patients-between-those-with-and-without-lower-third-of-vaginal-invasion
#6
Kanyarat Katanyoo
OBJECTIVE: To evaluate treatment outcomes between stage IIIB cervical cancer with and without lower third of vaginal invasion (LTI) in terms of response to treatment and overall survival (OS). METHODS: Matching one patient with LTI for 2 patients without LTI who had completed treatment between 1995 and 2012 were conducted by using treatment modalities (radiation therapy [RT] alone vs. concurrent chemoradiation therapy [CCRT]) and tumor histology (squamous cell carcinoma [SCC] vs...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29025633/association-between-male-circumcision-and-women-s-biomedical-health-outcomes-a-systematic-review
#7
Jonathan M Grund, Tyler S Bryant, Inimfon Jackson, Kelly Curran, Naomi Bock, Carlos Toledo, Joanna Taliano, Sheng Zhou, Jorge Martin Del Campo, Ling Yang, Apollo Kivumbi, Peizi Li, Sherri Pals, Stephanie M Davis
BACKGROUND: Male circumcision reduces men's risk of acquiring HIV and some sexually transmitted infections from heterosexual exposure, and is essential for HIV prevention in sub-Saharan Africa. Studies have also investigated associations between male circumcision and risk of acquisition of HIV and sexually transmitted infections in women. We aimed to review all evidence on associations between male circumcision and women's health outcomes to benefit women's health programmes. METHODS: In this systematic review we searched for peer-reviewed and grey literature publications reporting associations between male circumcision and women's health outcomes up to April 11, 2016...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29025277/clinical-analysis-of-recurrence-patterns-in-patients-with-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#8
Lijun Wang, Yesong Guo, Jianhua Xu, Zhenzhang Chen, Xuesong Jiang, Lanfang Zhang, Shengfu Huang, Xia He, Yiqin Zhang
OBJECTIVE: To evaluate the characteristics and risk factors for locoregional recurrence in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). METHODS: The clinical diagnosis and treatment data of 195 patients with NPC treated with IMRT from March 2005 to May 2010 (including 9, 24, 70, and 92 cases of stage I, II, III, and IV disease, respectively, according to the 7th edition American Joint Committee on Cancer staging criteria) were retrospectively analyzed...
October 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29024167/imaging-spinal-cord-atrophy-in-progressive-myelopathies-htlv-i-associated-neurologic-disease-ham-tsp-and-multiple-sclerosis-ms
#9
Shila Azodi, Govind Nair, Yoshimi Enose-Akahata, Emily Charlip, Ashley Vellucci, Irene Cortese, Jennifer Dwyer, B Jeanne Billioux, Thomas Chevaz, Joan Ohayon, Daniel S Reich, Steven Jacobson
OBJECTIVE: Previous work measures spinal cord thinning in chronic progressive myelopathies, including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). Quantitative measurements of spinal cord atrophy are important in fully characterizing these and other spinal cord diseases. We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers. METHODS: Spinal cord cross sectional area was measured in individuals (24 healthy controls (HC), 17 asymptomatic carriers of HTLV-1 (AC), 47 HAM/TSP, 74 RRMS, 17 SPMS, and 40 PPMS) from C1 to T10...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29023464/role-of-p16-testing-in-cervical-cancer-screening-among-hiv-infected-women
#10
Christine J McGrath, Rochelle Garcia, Trong T Trinh, Barbra A Richardson, Grace C John-Stewart, Evans Nyongesa-Malava, Nelly R Mugo, Emily H Glynn, Samah R Sakr, Hugo De Vuyst, Michael H Chung
BACKGROUND: p16 immunohistochemistry is used to evaluate for HPV-associated cervical intraepithelial neoplasia. The diagnostic performance of p16 in HIV infection is unclear. METHODS: Between June-December 2009, HIV-infected women underwent Papanicolaou (Pap) smear, human papillomavirus (HPV) testing, visual inspection with acetic acid (VIA), and colposcopy-directed biopsy as the disease gold standard at a HIV clinic in Kenya. Pap smears were evaluated for p16 expression...
2017: PloS One
https://www.readbyqxmd.com/read/29022644/assessment-of-risk-factors-in-metastatic-recurrent-tall-cell-variant-of-papillary-thyroid-carcinoma
#11
Kursat Okuyucu, Engin Alagoz, Semra Ince, Nuri Arslan
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Typical example is the tall cell variant (TCV). Patients experience a greater incidence of recurrence, nodal and extranodal metastases, tumor associated mortality than other variants of PTC. Studies related to TCV almost always compared it with its patient population of PTC according to risk factors and clinicopathologic features...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022484/prognostic-implication-of-simultaneous-anemia-and-lymphopenia-during-concurrent-chemoradiotherapy-in-cervical-squamous-cell-carcinoma
#12
Oyeon Cho, Mison Chun, Young-Taek Oh, O Kyu Noh, Suk-Joon Chang, Hee-Sug Ryu, Eun Ju Lee
Radioresistance often leads to poor survival in concurrent chemoradiotherapy-treated cervical squamous cell carcinoma, and reliable biomarkers can improve prognosis. We compared the prognostic potential of hemoglobin, absolute neutrophil count, and absolute lymphocyte count with that of squamous cell carcinoma antigen in concurrent chemoradiotherapy-treated squamous cell carcinoma. We analyzed 152 patients with concurrent chemoradiotherapy and high-dose-rate intracavitary brachytherapy-treated cervical squamous cell carcinoma...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29022077/no-association-between-periodontitis-and-preterm-low-birth-weight-a-case-control-study
#13
Mariana Fampa Fogacci, Elaine de O C Cardoso, Davi da S Barbirato, Denise Pires de Carvalho, Carmelo Sansone
PURPOSE: This study aimed to investigate the association between periodontitis in pregnant women and adverse pregnancy outcomes by heeding confounding risk factors for preterm low birth weight infants. METHODS: This study was reported according to The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement. A case-control study was conducted. Medical records of all pregnant women attending a prenatal care clinic were screened. Those between 21 and 34 years and gestational age of 28-32 weeks were initially enrolled in the study...
October 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29021759/effects-of-gladiolus-dalenii-on-the-stress-induced-behavioral-neurochemical-and-reproductive-changes-in-rats
#14
David Fotsing, Gwladys T Ngoupaye, Agnes C Ouafo, Stephanie K J Njapdounke, Yongabi A Kenneth, Elisabeth Ngo Bum
Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, epilepsy, schizophrenia, and mood disorders. Recent studies have revealed that the aqueous extract of G. dalenii (AEGD) exhibited antidepressant-like properties in rats. Therefore, we hypothesized that the AEGD could protect from the stress-induced behavioral, neurochemical, and reproductive changes in rats. The objective of the present study was to elucidate the effect of the AEGD on behavioral, neurochemical, and reproductive characteristics, using female rats subjected to chronic immobilization stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29021682/spontaneous-regression-of-retro-odontoid-post-traumatic-cicatrix-following-occipitocervical-fixation
#15
Priyank Sinha, Ming-Te Lee, Sasan Panbehchi, Ankur Saxena, Debasish Pal
This case report describes a patient who presented with myelopathy secondary to a large retro-odontoid post traumatic cicatrix. The objective of this study was to discuss the clinical presentation, pathogenesis, imaging, and surgical management of pseudoarthrosis tissue mass associated with odontoid nonunion. Atlantoaxial subluxation (AAS) has been widely reported in patients with rheumatoid arthritis. AAS leads to repeated cycles of partial tear and repair of ligaments around the altantoaxial complex, resulting in the formation of periodontoid mass (pseudotumor)...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29021429/sclerosing-esophagitis-with-igg4-positive-plasma-cell-infiltration-a-case-report
#16
Shigeo Mori, Yoshiya Tahashi, Kazushige Uchida, Tsukasa Ikeura, Naoyuki Danbara, Takahiro Wakamatsu, Takeo Kusuda, Yu Takahashi, Masato Yanagawa, Mitsunobu Matsushita, Chisato Ohe, Taku Michiura, Kentaro Inoue, Masanori Kon, Kazuichi Okazaki
The patient was a 76-year-old woman who had noticed slight difficulty in swallowing in the 3 years prior to this presentation. Her dysphagia progressed while she was hospitalized following cervical cancer surgery. Esophagogastroduodenoscopy and an esophagram showed circumferential erosion and a stricture of the thoracic esophagus. Esophageal resection was performed; the resected specimens showed a stricture and wall thickening. Histologically, transmural hyperplasia, which consisted of inflammatory granulation tissue with the abundant infiltration of IgG4-positive plasma cells and lymphocytes, was observed...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021401/rnaseq-analysis-of-differentiated-keratinocytes-reveals-a-massive-response-to-late-events-during-human-papillomavirus-type-16-infection-including-loss-of-epithelial-barrier-function
#17
T Klymenko, Q Gu, I Herbert, A Stevenson, V Iliev, G Watkins, C Pollock, R Bhatia, K Cuschieri, P Herzyk, D Gatherer, S V Graham
The human papillomavirus (HPV) replication cycle is tightly linked to epithelial cell differentiation. To examine HPV-associated changes in the keratinocyte transcriptome, RNAs isolated from undifferentiated and differentiated cell populations of normal, spontaneously immortalised, keratinocytes (NIKS), and NIKS stably transfected with HPV16 episomal genomes (NIKS16), were compared using RNASeq. HPV16 infection altered expression of 2862 cellular genes. Next, to elucidate the role of keratinocyte gene expression in late events during the viral life cycle, RNASeq was carried out on triplicate differentiated populations of NIKS (uninfected) and NIKS16 (infected)...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29021311/acute-ischemic-stroke-with-tandem-lesions-technical-endovascular-management-and-clinical-outcomes-from-the-escape-trial
#18
Zarina Assis, Bijoy K Menon, Mayank Goyal, Andrew M Demchuk, Jai Shankar, Jeremy L Rempel, Daniel Roy, Alexander Y Poppe, Victor Yang, Cheemun Lum, Dar Dowlatshahi, John Thornton, Hana Choe, Paul A Burns, Donald F Frei, Blaise W Baxter, Michael D Hill
BACKGROUND: Tandem occlusions of the extracranial carotid and intracranial carotid or middle cerebral artery have a particularly poor prognosis without treatment. Several management strategies have been used with no clear consensus recommendations. We examined subjects with tandem occlusions enrolled in the ESCAPE trial and their outcomes. METHODS: Data are from the ESCAPE trial. Additional data were sought on interventions for each subject. RESULTS: There were 54 (17%) subjects with tandem extracranial and intracranial occlusions...
October 11, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29020789/-the-role-of-maternal-imunity-and-woman%C3%A2-s-microbiome-in-the-pathogenesis-of-preterm-labor
#19
M Koucký, K Malíčková, J Hrdý, A Černý, H Hrbáčková, P Šimják, A Pařízek
OBJECTIVE: To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice. SETTING: Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital. DESIGN: Review article. METHODS: Compilation od published data from scientific literature. CONCLUSION: Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29020099/experiences-of-cervical-cancer-patients-in-rural-ghana-an-exploratory-study
#20
Charity Binka, David Teye Doku, Kofi Awusabo-Asare
Even though cervical cancer is quite a prevalent disease in Ghana, there is hardly any study on this disease. This paper sought to explore the experiences of cervical cancer patients living with the disease with emphasis on their knowledge about the disease before and after the diagnosis. Qualitative data were collected through in-depth interviews with cervical cancer patients undergoing treatment in a specialised cancer treatment health facility in rural Ghana. Cervical cancer patients had inadequate knowledge about the disease, its symptoms, risk factors, treatment and prevention prior to being diagnosed of the disease...
2017: PloS One
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