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Vulvar diseases

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https://www.readbyqxmd.com/read/27907089/detection-of-human-papillomavirus-infection-in-patients-with-vaginal-intraepithelial-neoplasia
#1
Cristina Lamos, Charlotte Mihaljevic, Sebastian Aulmann, Thomas Bruckner, Christoph Domschke, Markus Wallwiener, Carmen Paringer, Herbert Fluhr, Sarah Schott, Christine Dinkic, Janina Brucker, Michael Golatta, Lisa Gensthaler, Michael Eichbaum, Christof Sohn, Joachim Rom
INTRODUCTION: Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. VAIN 1 is also known as a low-grade squamous intraepithelial lesion (LSIL), whereas VAIN 2 and VAIN 3 both represent high-grade squamous intraepithelial lesions (HSIL)...
2016: PloS One
https://www.readbyqxmd.com/read/27897023/-current-knowledge-about-hpv-infection
#2
A Mladěnka, A Kubečková, J Sláma
OBJECTIVE: Overview of current data on HPV infection. DESIGN: Review article. SETTING: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava, Clinic of Obstetrics and Gynecology, University Hospital in Hradec Králové, Clinic of Gynecology and Obstetrics, General University Hospital in Prague. METHODS AND RESULTS: Human papillomavirus is a sexually transmitted pathogen that causes anogenital disorders...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27894614/giant-vulvar-verruciform-xanthoma-can-mimic-a-common-vulvar-mass-genital-warts
#3
Sa Ra Lee, Ji Hyun Jeon, Kyungah Jeong, Hye Won Chung
Vulvar xanthoma, especially grown in verruciform, can mimic a common gynecologic vulvar disease, genital warts.
November 25, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27882758/-vulvar-squamous-precancerous-lesions-history-and-current-state-of-the-topic
#4
L Ševčík, P Škapa, Y Vantuchová, V Benčík
This review article discribes the genesis and development of vulvar squamous precancerous lesions terminology and discusses the consensus of the International Society for the Study of Vulvovaginal Disease, the American Society for Colposcopy and Cervical Pathology, College of American Pathologists and the World Health Organization on the current terminology. The article describes the different types of vulvar squamous precancerous lesions, according to their etiology, incidence and malignant potential.
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27881380/vulvar-inflammation-a-presentation-of-crohn-s-disease
#5
Carla Ferreira, Joana Soares, Tiago Maia, Joana Pardal, Ana Nogueira, Marta Tavares, Eunice Trindade, Jorge Amil Dias
No abstract text is available yet for this article.
November 23, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27878356/phase-i-trial-of-daily-triapine-in-combination-with-cisplatin-chemotherapy-for-advanced-stage-malignancies
#6
Charles A Kunos, Edward Chu, Jan H Beumer, Mario Sznol, S Percy Ivy
PURPOSE: Advanced-stage malignancies have increased deoxyribonucleotide demands in DNA replication and repair, making deoxyribonucleotide supply a potential exploitable target for therapy based on ribonucleotide reductase (RNR) inhibition. METHODS: A dose-finding phase I trial was conducted of intravenous (i.v.) triapine, a small-molecule RNR inhibitor, and cisplatin chemotherapy in patients with advanced-stage solid tumor malignancies. Patients received dose-finding levels of i...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27876410/clinical-outcome-of-high-dose-rate-interstitial-brachytherapy-in-vulvar-cancer-a-single-institutional-experience
#7
Umesh Mahantshetty, Pushpa Naga, Reena Engineer, Supriya Sastri, Yogesh Ghadi, Udita Upreti, Vijaya Somesan, Sudarshan Kadam, Satish Kohle, Deepak Deshpande, Shyam Kishore Shrivastava
PURPOSE: With an aim to evaluate and report high dose date interstitial brachytherapy (HDR-ISBT) in vulvar cancers, we undertook this retrospective analysis. METHODS AND MATERIALS: Histologically proven vulvar cancers treated with HDR-ISBT between 2001 and 2016 were analyzed. Radiotherapy details, clinical outcome in terms of local control rates, survivals, and toxicities were evaluated. RESULTS: A total of 38 patients received HDR-ISBT, with definitive radiation in 29 (76...
November 19, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27872543/extra-mammary-paget-s-disease-of-vulva-a-case-report
#8
Than Singh Tomar, Suchetha Sambasivan, Rema Prabhakaran Nair, Shaji Thomas, Preethi T Ramadas
Extra mammary Paget's disease (EMPD) is a rare condition involving the vulva, anogenital region, and axilla. Vulvar disease usually presents as a slow growing well-defined itchy plaque with crustations or ulcerations over the affected area in postmenopausal women. Well-established guidelines for diagnosis and management are not available for this rare condition. Our patient is a 64-year-old postmenopausal woman with a history of similar complaints of 2 years duration, not responding to multiple topical treatments...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27870709/groin-recurrences-in-node-negative-vulvar-cancer-patients-after-sole-sentinel-lymph-node-dissection
#9
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Peter Hillemanns
OBJECTIVE: This study aimed to evaluate the recurrence rates after sole sentinel dissection in vulvar cancer and describe characteristics of groin recurrences. METHODS: All vulvar cancer cases between 2008 and 2014 were reviewed. Inclusion criteria were restricted to lymph node-negative patients, sole sentinel lymph node dissection (SLND), and tumor diameter less than 4 cm. In all patients, Tc-99m nanocolloid was used for preoperative SLN imaging. Regularly, planar lymphoscintigraphy and single-photon emission computed tomography with computed tomography were performed...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27864932/hpv-status-and-favorable-outcome-in-vulvar-squamous-cancer
#10
Katie Wakeham, Kim Kavanagh, Kate Cuschieri, David Millan, Kevin G Pollock, Sarah Bell, Kevin Burton, Nicholas S Reed, Sheila V Graham
It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27864417/tumor-thickness-and-mitotic-rate-robustly-predict-melanoma-specific-survival-in-patients-with-primary-vulvar-melanoma-a-retrospective-review-of-100-cases
#11
Priyadharsini Nagarajan, Jonathan L Curry, Jing Ning, Jin Piao, Carlos A Torres Cabala, Phyu P Aung, Doina Ivan, Merrick I Ross, Charles F Levenback, Michael Frumovitz, Jeffrey E Gershenwald, Michael A Davies, Anais Malpica, Victor Prieto, Michael T Tetzlaff
PURPOSE: Primary vulvar melanoma (PVM) is the second most common vulvar malignancy. Despite their distinct anatomic site and unique molecular-genetic alterations, PVMs are staged according to the American Joint Committee on Cancer (AJCC) guidelines for primary cutaneous melanomas (PCM). However, whether parameters derived for PCM also apply to PVM remains a critical yet largely unexplored clinical question. The objective of this study was to determine the parameters predictive of survival in PVM...
November 18, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27843030/adjuvant-radiation-therapy-for-margin-positive-vulvar-squamous-cell-carcinoma-defining-the-ideal-dose-response-using-the-national-cancer-data-base
#12
Bhavana V Chapman, Beant S Gill, Akila N Viswanathan, Goundappa K Balasubramani, Paniti Sukumvanich, Sushil Beriwal
PURPOSE: Positive surgical margins after radical vulvectomy for vulvar cancer portend a high risk for local relapse, which may be challenging to salvage. We assessed the impact of adjuvant radiation therapy (aRT) on overall survival (OS) and the dose-response relationship using the National Cancer Data Base. METHODS AND MATERIALS: Patients with vulvar squamous cell carcinoma who underwent initial extirpative surgery with positive margins from 1998 to 2012 were included...
September 24, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27836203/patient-treatment-and-discharge-factors-associated-with-hospital-readmission-within-30days-after-surgery-for-vulvar-cancer
#13
K M Dorney, W B Growdon, J Clemmer, J A Rauh-Hain, T R Hall, E Diver, D Boruta, M G Del Carmen, A Goodman, J O Schorge, N Horowitz, R M Clark
OBJECTIVES: The majority of hospital readmissions are unexpected and considered adverse events. The goal of this study was to examine the factors associated with unplanned readmission after surgery for vulvar cancer. METHODS: Patient demographic, treatment, and discharge factors were collected on 363 patients with squamous cell carcinoma in situ or invasive cancer who underwent vulvectomy at our institution between January 2001 and June 2014. Clinical variables were correlated using χ(2) test and Student's t-test as appropriate for univariate analysis...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27832810/eccrine-porocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#14
Ayako Fujimine-Sato, Masafumi Toyoshima, Shogo Shigeta, Asami Toki, Takashi Kuno, Izumi Sato, Mika Watanabe, Hitoshi Niikura, Nobuo Yaegashi
BACKGROUND: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Eccrine porocarcinoma is a rare malignant tumor arising from sweat glands. The incidence of eccrine porocarcinoma is estimated at 0.005-0.01 % of all cutaneous tumors. To the best of our knowledge, only seven previous cases of vulvar eccrine porocarcinoma have been reported in the English-language literature...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832673/extramammary-paget-disease-of-the-vulva-case-report
#15
Bianca Ruschel Hillmann, Amanda Amaro Pereira, Luiz Fernando Sommacal
Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. The treatment of choice is wide excision with margins, which leads to sequelae, functional and aesthetic. Recurrence is common. This article reports the case of a 48-year-old female patient with history of vulvar itching for the past 2 years, who had been submitted to various treatments for benign pathologies...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27802342/propensity-scoring-after-multiple-imputation-in-a-retrospective-study-on-adjuvant-radiation-therapy-in-lymph-node-positive-vulvar-cancer
#16
Christine Eulenburg, Anna Suling, Petra Neuser, Alexander Reuss, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Linn Woelber, Sven Mahner
Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE)...
2016: PloS One
https://www.readbyqxmd.com/read/27798870/immunological-and-clinical-impact-of-cancer-stem-cells-in-vulvar-cancer-role-of-cd133-cd24-abcg2-expressing-cells
#17
Chiara Napoletano, Filippo Bellati, Ilary Ruscito, Milena Pernice, Ilaria Grazia Zizzari, Salvatore Caponnetto, Federica Tomao, Luigi Frigerio, Marco Liberati, Aurelia Rughetti, Donatella Caserta, Pierluigi Benedetti Panici, Marianna Nuti
BACKGROUND: Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is known regarding biological markers able to predict patient prognosis. We investigated the presence and clinical impact of CSCs and infiltrating Treg in primary vulvar cancer...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27789051/-multiple-epidermolytic-acanthomas-of-the-genitalia
#18
I Moulonguet, M Serre, D Herskovitch
BACKGROUND: Epidermolytic hyperkeratosis presents a particular histological image common to several clinical pictures, including that of keratinopathic ichthyoses. It may also occur fortuitously in various tumoral and inflammatory lesions. It is the elementary histopathological lesion of epidermolytic acanthoma, which may either be single or multiple, and when it occurs in the genital area, is known as epidermolytic hyperkeratosis of the genitalia or multiple epidermolytic acanthoma of the genitalia...
October 24, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27788531/giant-condyloma-buschke-loewenstein-tumor-in-a-16-year-old-patient-case-report
#19
Caetano Galvão Petrini, Patrícia Pereira Dos Santos Melli, Pedro Sérgio Magnani, Laura Penna Rocha, Francesca Maia Faria, Geraldo Duarte, Silvana Maria Quintana
The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Surgical excision is the recommended treatment in most cases. We present the case of a 16 years old female patient with extensive vulvar lesions successfully treated surgically...
September 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27775259/major-clinical-research-advances-in-gynecologic-cancer-in-2015
#20
REVIEW
Dong Hoon Suh, Miseon Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed...
November 2016: Journal of Gynecologic Oncology
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