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Vulvar diseases

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https://www.readbyqxmd.com/read/29745285/p16-expression-in-extramammary-paget-s-disease-of-the-vulva-and-scrotum-is-not-human-papillomavirus-related
#1
Khaleel I Al-Obaidy, Chia-Sui Kao, Muhammad T Idrees
INTRODUCTION: Extramammary Paget disease (EMPD) of the vulva has been shown to express p16 by immunohistochemistry (IHC), however, p16 expression in the vulva and scrotum has not been extensively studied in relation to human papillomavirus (HPV) within EMPD of both the vulva and scrotum. DESIGN: Twenty-two cases of EMPD (vulva, 16; scrotum, 6) were found in our laboratory information system. P16 and HPV IHC were performed. Any p16 reactivity less than 10% was considered negative...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#2
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29742673/trends-in-place-of-death-among-patients-with-gynecologic-cancer-in-the-united-states
#3
Katherine Hicks-Courant, Alexander Melamed, Michael J Worley, Young Bae Kim, John O Schorge, J Alejandro Rauh-Hain
OBJECTIVE: To describe the change over time in place of death (hospital, home, hospice) among all women in the United States who died of gynecologic malignancies and compare them with other leading causes of female cancer deaths. METHODS: This is a retrospective cross-sectional study using national death certificate data from the Mortality Multiple Cause-of-Death Public Use Record Data. All women who died from gynecologic, breast, lung, and colorectal cancers were identified according to International Classification of Diseases, 10 Revision, cause of death from 2003 to 2015...
June 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742668/effects-of-the-affordable-care-act-on-young-women-with-gynecologic-cancers
#4
Anna Jo Bodurtha Smith, Amanda N Fader
OBJECTIVE: To evaluate the effects of the dependent coverage mandate of the 2010 Affordable Care Act (ACA) on insurance status, stage at diagnosis, and receipt of fertility-sparing treatment among young women with gynecologic cancer. METHODS: We used a difference-in-differences design to assess insurance status, stage at diagnosis (stage I-II vs III-IV), and receipt of fertility-spearing treatment before and after the 2010 ACA among young women aged 21-26 years vs women aged 27-35 years...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29736362/preoperative-elevated-platelet-count-as-a-prognostic-factor-in-vulvar-squamous-cell-cancer-a-mini-review
#5
REVIEW
Ahmed Abu-Zaid, Osama Alomar, Hany Salem
Preoperative thrombocytosis has been shown to be a marker of advanced disease and poor survival in gynecologic malignancies, specifically endometrial, ovarian, and cervical cancers. The aim of this study is to provide a focused mini-review on all the existing literature concerning the role of preoperative thrombocytosis as a prognostic factor in vulvar squamous cell cancer (SCC). A PubMed search (until February 20, 2018) of all peer-reviewed and English-published articles was conducted using the following keywords: platelet, thrombocytosis, and vulvar cancer...
March 6, 2018: Curēus
https://www.readbyqxmd.com/read/29723364/most-frequent-dermatoses-at-a-vulvar-pathology-outpatient-clinic
#6
Gabriella Cerazi Sartori, Rafaela Tricca Wicher, Flávia Regina Ferreira, Valéria Holmo Batista
The vulva corresponds to the external female genitalia. Special features of this region favor a wide range of diseases, whose knowledge allows for better clinical management, impacting on the quality of life. This is a cross-sectional and descriptive study carried out at a vulvar pathology outpatient clinic, between May and December/ 2015. Data obtained from a standard form included demographic parameters, habits, and vulvar dermatosis and allowed to identify the epidemiological profile of patients with vulvar dermatosis treated in this outpatient clinic and to determine the most prevalent dermatoses...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29659752/performance-of-anal-cytology-compared-with-high-resolution-anoscopy-and-histology-in-women-with-lower-anogenital-tract-neoplasia
#7
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke de Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking. Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia. Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29622067/-lipsch%C3%A3-tz-ulcus-as-a-differential-diagnosis-of-vulvar-ulcus
#8
Stine Kretzschmar Nielsen, Malou Eva Maria Pinto Barbosa
Lipschütz ulcus (LU) is a rare and probably underdiagnosed non-venereal disease, which usually presents in young women. It is characterised by an acute onset of influenza-like symptoms with painful, necrotic ulcerations on the vulva or lower vagina, and the aetiology and pathogenesis is unknown. The diagnosis is clinical after exclusion of other causes of vulvar ulcers. LU heals spontaneously within 4-6 weeks, and treatment is mainly symptomatic.
April 2, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29605048/racial-and-ethnic-disparities-over-time-in-the-treatment-and-mortality-of-women-with-gynecological-malignancies
#9
J Alejandro Rauh-Hain, Alexander Melamed, Diego Schaps, Amy J Bregar, Ryan Spencer, John O Schorge, Laurel W Rice, Marcela G Del Carmen
OBJECTIVE: To examine temporal trends in treatment and survival among black, Asian, Hispanic, and white women diagnosed with endometrial, ovarian, cervical, and vulvar cancer. METHODS: Using the National Cancer Database (2004-2014), we identified women diagnosed with endometrial, ovarian, cervical, and vulvar cancer. For each disease site, we analyzed race/ethnicity-specific trends in receipt of evidence-based practices. Professional societies' recommendations were used to define these practices...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29596526/abo-blood-groups-as-a-prognostic-factor-for-recurrence-in-ovarian-and-vulvar-cancer
#10
Céline Montavon Sartorius, Andreas Schoetzau, Henriette Kettelhack, Daniel Fink, Neville F Hacker, André Fedier, Francis Jacob, Viola Heinzelmann-Schwarz
The relationship between ABO blood groups (BG) and risk of incidence in cancers including gynecological cancers has been widely studied, showing increased incidence risk for BG A patients. As available data are inconsistent we investigated whether BG and their anti-glycan antibodies (anti-A and anti-B) have prognostic values in gynecological cancers. We retrospectively evaluated 974 patients with gynecological cancers in three cancer centers (Switzerland and Australia) between 1974 and 2014 regarding the relationships between clinico-pathological findings and the BG...
2018: PloS One
https://www.readbyqxmd.com/read/29594213/survival-and-failure-types-after-radiation-therapy-of-vulvar-cancer
#11
Christina Steen Vorbeck, Ivan Richter Vogelius, Marie Louise Vorndran Cøln Banner-Voigt, Hanne From Mathiesen, Mansoor Raza Mirza
Background and purpose: Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone. Material and methods: We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 2014. Survival was estimated using the Kaplan-Meier method. We performed a competing risk analysis and included five competing events: loco-regional failure (LRF), distant metastasis, LRF plus distant metastasis, and death without evidence of disease, with the remaining patients denoted alive without evidence of disease...
August 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29570138/vulvovaginal-disease-education-in-canadian-and-american-gynecology-residency-programs-a-survey-of-program-directors
#12
Christine Edwards, Nupur Dogra, Annet Antanrajakumar, Aparna Sarangapani, Amanda Selk
OBJECTIVE: The aims of the study were to assess and describe the current vulvovaginal curriculum in gynecology residency training programs in Canada and the United States and to compare this with national training objectives. MATERIALS AND METHODS: A 22-question electronic survey was sent to 252 gynecology program directors in Canada and the United States between September 2015 and July 2016 using the platform SurveyMonkey.com. Survey responses were entered into SPSS Version 23, and analysis was performed using descriptive statistics...
March 22, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29555332/vulvar-cancer-two-pathways-with-different-localization-and-prognosis
#13
F Hinten, A Molijn, L Eckhardt, L F A G Massuger, W Quint, P Bult, J Bulten, W J G Melchers, J A de Hullu
BACKGROUND: Two etiologic pathways for vulvar squamous cell carcinoma (SCC) are described: in a background of lichen sclerosus and/or differentiated vulvar intraepithelial neoplasia and related to high-risk human papillomavirus (HPV) infection with high grade squamous intraepithelial lesion (HSIL) as precursor. The aim was to compare the predilection site and survival of HPV-related to non HPV-related vulvar SCCs. METHODS: Data of patients treated for primary vulvar SCC at the Radboudumc between March 1988 and January 2015 were analyzed...
May 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29530664/vulvar-field-resection-based-on-ontogenetic-cancer-field-theory-for-surgical-treatment-of-vulvar-carcinoma-a-single-centre-single-group-prospective-trial
#14
Michael Höckel, Sophia Trott, Nadja Dornhöfer, Lars-Christian Horn, Bettina Hentschel, Benjamin Wolf
BACKGROUND: The incidence of vulvar cancer is increasing, but surgical treatment-the current standard of care-often leads to unsatisfactory outcomes, especially in patients with node-positive disease. Preliminary results at our centre showed that locoregional spread of vulvar carcinoma occurs within tissue domains defined by stepwise embryonic and fetal development (ontogenetic cancer fields and associated lymph node regions). We propose that clinical translation of these insights into practice could improve outcomes of surgical treatment of vulvar cancer...
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29524285/vulvar-neoplasms-in-275-women-with-genital-lichen-sclerosus-and-impact-of-treatment-a-retrospective-chart-review
#15
LETTER
E A Dell, R Y N Miest, C M Lohse, R R Torgerson
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29492231/potential-delay-in-the-diagnosis-of-vulvar-cancer-and-associated-risk-factors-in-women-treated-in-german-gynecological-practices
#16
Jennifer Muigai, Louis Jacob, Konstantinos Dinas, Karel Kostev, Matthias Kalder
The goal of this study was to estimate a potential delay in the diagnosis of vulvar cancer and identify associated risk factors in women treated in gynecological practices in Germany. The current study sample included 1,652 women from 218 gynecological practices who received an initial diagnosis of vulvar cancer (ICD 10: C51) between January 2000 and December 2015 (index date). After applying several exclusion criteria, 505 non-cancer controls were matched (1:1) to 505 vulvar cancer cases based on age, health insurance status, and index date...
February 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29484212/a-very-rare-case-hpv-negative-vulvar-cancer-in-an-adolescent
#17
Ilker Kahramanoglu, Hasan Turan, Yahya Ozgun Oner, Tugan Bese, Sennur Ilvan, Macit Arvas, Fuat Demirkiran
Carcinoma of the vulva is usually regarded as a disease of older women, with the typical age of 65-85 years. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. Vulvar radical local excision and bilateral inguinal sentinel lymph node biopsies were performed. The clitoris was preserved during the surgery...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29474239/-the-future-of-vulvar-disease-new-and-ongoing-challenges-presidential-lecture-xxiv-world-congress-2017-mendoza-argentina
#18
Claudia Marchitelli
The 21st century brought along a number of discoveries and medical advances. With the advances, we can mention the following: target therapies for cancer, genomics and molecular biology, pharmacogenomics, minimally invasive and robotic surgery, immunosuppressive therapies in transplant patients, human papillomavirus in the era of vaccination, and aesthetic vulvovaginal procedures. All of them have greatly influenced medicine. As a scientific society, we have several challenges. In the past, you had to go to a library to get information...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29469786/primary-vulvar-paget-disease-the-importance-of-clinical-suspicion
#19
Fernando Mota, Miguel Horta, Claudia Marques, Susan Foreid, Manuela Selores
Extramammary Paget disease of the vulva is a rare condition that accounts for only 1-2% of vulvar malignancies and represents a frequent cause of misdiagnosis. It is most commonly seen in postmenopausal women. Clinically it is similar to Paget disease of the breast, appearing as red, well-demarcated eczematoid lesions, with slightly raised edges. A high degree of clinical suspicion is very important when evaluating these lesions in order to avoid misdiagnosis and delay of effective treatment. We present a case of vulvar Paget disease treated with vulvectomy...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469170/is-non-response-to-fluconazole-maintenance-therapy-for-recurrent-candida-vaginitis-related-to-sensitization-to-atopic-reactions
#20
Gilbert G G Donders, Svitrigaile Grinceviciene, Gert Bellen, Martin Jaeger, Jaap Ten Oever, Mihai G Netea
PROBLEM: Is sensitization to atopic reaction related to treatment response of recurrent Candida vulvovaginal (RVVC)? METHOD OF THE STUDY: Analysis of ReCiDiF trial data of optimal (OR) and non-responders (NR) to fluconazole maintenance treatment, to explore medical history, physical status, family history, and vaginal immune response for potential sensitization to atopic reaction. RESULTS: Sociodemographic characteristics of 33 NR women were not different from 38 OR...
April 2018: American Journal of Reproductive Immunology: AJRI
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