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oral health and chronic kidney disease

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https://www.readbyqxmd.com/read/28644432/dental-implant-treatment-for-renal-failure-patients-on-dialysis-a-clinical-guideline
#1
REVIEW
Quan Yuan, Qiu-Chan Xiong, Megha Gupta, Rosa María López-Pintor, Xiao-Lei Chen, Dutmanee Seriwatanachai, Michael Densmore, Yi Man, Ping Gong
Chronic kidney disease (CKD) is a worldwide public health problem that is growing in prevalence and is associated with severe complications. During the progression of the disease, a majority of CKD patients suffer oral complications. Dental implants are currently the most reliable and successful treatment for missing teeth. However, due to complications of CKD such as infections, bone lesions, bleeding risks, and altered drug metabolism, dental implant treatment for renal failure patients on dialysis is more challenging...
June 23, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28576451/elbasvir-plus-grazoprevir-in-patients-with-hepatitis-c-virus-infection-and-stage-4-5-chronic-kidney-disease-clinical-virological-and-health-related-quality-of-life-outcomes-from-a-phase-3-multicentre-randomised-double-blind-placebo-controlled-trial
#2
Annette Bruchfeld, David Roth, Paul Martin, David R Nelson, Stanislas Pol, Maria-Carlota Londoño, Howard Monsour, Marcelo Silva, Peggy Hwang, Jean-Marie Arduino, Michael Robertson, Bach-Yen Nguyen, Janice Wahl, Eliav Barr, Wayne Greaves
BACKGROUND: In the C-SURFER study, therapy with the all-oral elbasvir plus grazoprevir regimen for 12 weeks in patients with chronic hepatitis C virus (HCV) infection and stage 4-5 chronic kidney disease resulted in a high rate of virological cure compared with placebo. Here, we report sustained virological response (SVR), safety data, health-related quality-of-life (HRQOL), and virological resistance analyses in patients in C-SURFER who received immediate antiviral therapy or who received placebo before therapy...
May 30, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28532432/periodontitis-and-early-mortality-among-adults-treated-with-hemodialysis-a-multinational-propensity-matched-cohort-study
#3
Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok, Paul Stroumza, Anna Bednarek-Skublewska, Jan Dulawa, Luc Frantzen, Domingo Del Castillo, Staffan Schon, Amparo G Bernat, Jorgen Hegbrant, Charlotta Wollheim, Letizia Gargano, Casper P Bots, Giovanni Fm Strippoli
BACKGROUND: Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney failure. METHODS: ORAL-D was a propensity matched analysis in 3338 dentate adults with end-stage kidney disease treated in a hemodialysis network in Europe and South America designed to examine the association between periodontitis and all-cause and cardiovascular-related mortality in people on long-term hemodialysis...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28443950/chronic-kidney-disease-determinants-of-progression-and-cardiovascular-risk-progredir-cohort-study-design-and-methods
#4
Maria Alice Muniz Domingos, Alessandra Carvalho Goulart, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28424878/oral-health-in-patients-with-renal-disease-a-longitudinal-study-from-predialysis-to-kidney-transplantation
#5
Karita M Nylund, Jukka H Meurman, Anna Maria Heikkinen, Jussi O Furuholm, Fernanda Ortiz, Hellevi M Ruokonen
OBJECTIVES: The aim of this longitudinal study was to compare the oral health of chronic kidney disease patients at the predialysis (baseline) and post-transplantation (follow-up) stages and to investigate differences in oral health between diabetic nephropathy and other kidney disease patients at follow-up. MATERIALS AND METHODS: Fifty-three kidney disease patients (34 men) aged 31-86 years were followed up to 157 months. Clinical and radiological oral examinations, salivary and laboratory analyses, and oral health behavior questionnaires were conducted at the predialysis and follow-up stages at Helsinki University Hospital, Finland...
April 20, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28419972/neprilysin-inhibitors-a-new-hope-to-halt-the-diabetic-cardiovascular-and-renal-complications
#6
REVIEW
Vajir Malek, Anil Bhanudas Gaikwad
Diabetes is an enormous and ever-growing calamity and a global public health threat of the 21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin-angiotensin system (RAS) denotes a key pharmacotherapy for the management of cardiovascular (CVD) and chronic kidney diseases (CKD), which are the leading causes of disability and death among diabetic patients. Neprilysin (NEP) inhibition, auxiliary to RAS blockage increases the bioavailability of natriuretic peptides and benefits the cardio-renal system...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28407463/number-of-existing-permanent-teeth-is-associated-with-chronic-kidney-disease-in-the-elderly-korean-population
#7
Hye-Sun Shin
Background/Aims: The aim of this study was to assess the association between the number of existing permanent teeth and chronic kidney disease (CKD) in a representative sample of the elderly Korean population. Methods: A total of 2,519 subjects who participated in the Korean National Health and Nutrition Examination Survey were cross-sectionally examined. The number of existing permanent teeth was evaluated by clinical oral examination. CKD was defined based on definition and classification by Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines...
April 14, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28386819/disease-burden-early-discontinuation-and-healthcare-costs-in-hepatitis-c-patients-with-and-without-chronic-kidney-disease-treated-with-interferon-free-direct-acting-antiviral-regimens
#8
Amy Puenpatom, Michael Hull, Jeffrey McPheeters, Kay Schwebke
BACKGROUND: Hepatitis C virus (HCV) is a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Direct-acting antiviral agents (DAAs) have improved HCV management in CKD patients, however real-world clinical practice data are limited. OBJECTIVE: This study examined the prevalence of CKD among HCV patients receiving oral DAAs in a real-world setting. Comorbidities, early discontinuation rates, and healthcare costs were compared between patients with and without CKD...
April 6, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28365236/the-assessment-of-the-chronic-hepatotoxicity-induced-by-polygoni-multiflori-radix-in-rats-a-pilot-study-by-using-untargeted-metabolomics-method
#9
Xin-Hua Xia, Yuan-Yuan Yuan, Mei Liu
Polygoni Multiflori Radix is the dried root of Polygonum multiflorum Thunb officially recorded in the Chinese Pharmacopoeia as HeShouWu (HSW) in Chinese pinyin. The processed HSW are commonly used in TCM to treat liver disease and Chinese Pharmacopoeia has described the actions of it to tonify liver-kidney, replenish essence and blood, blacken beard and hair, strengthen sinew and bone, and resolve turbidity and lower lipid hence making it use not only as a herbal medicine in TCM but also as supplementary food in health care...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28328083/oral-iron-supplementation-potential-implications-for-the-gut-microbiome-and-metabolome-in-patients-with-ckd
#10
REVIEW
Guus A M Kortman, Dorien Reijnders, Dorine W Swinkels
Patients with chronic kidney disease (CKD) and loss of kidney function are at increased risk for morbidity and mortality. The risks of CKD are attributed to "uremia," an increased concentration of uremic retention solutes (toxins) in the plasma. Recently, a colo-renal axis became clearly apparent and uremia has been associated with an altered gut microbiome composition and metabolism. There is a high prevalence of anemia in patients with CKD, for which patients are often treated with oral or intravenous iron...
June 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28328023/identification-of-microorganisms-in-biofluids-of-individuals-with-periodontitis-and-chronic-kidney-disease-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#11
Levy Anderson César Alves, Rafael Celestino Souza, Taciana Mara Couto da Silva, Andreia Watanabe, Meriellen Dias, Maria Anita Mendes, Ana Lídia Ciamponi
RATIONALE: Chronic kidney disease (CKD) and periodontitis (PD) are important health issues. There is a large variety of microorganisms related to the pathogenesis of periodontitis, and optimising the time and the cost of laboratory assays to detect these organisms is highly valuable in the medical field. METHODS: Bacteria were isolated from saliva and oral biofilm of 30 adolescents and young adults with definite medical and dental diagnosis of CKD and PD, respectively, and proteins were extracted for microorganism identification by means of the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) technique...
May 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28316002/the-impact-of-periodontal-disease-on-physical-and-psychological-domains-in-long-term-hemodialysis-patients-a-cross-sectional-study
#12
Gabriel Veisa, Alexandra Tasmoc, Ionut Nistor, Liviu Segall, Dimitrie Siriopol, Sorina Mihaela Solomon, Mihaela Dora Donciu, Luminita Voroneanu, Andra Nastasa, Adrian Covic
PURPOSE: Periodontal disease is a chronic infectious disease. Individuals with end-stage kidney disease (ESKD) experience impaired quality of life (QoL) and low oral health. This is the first comprehensive study which aimed to explore the link between periodontal disease and quality of life, assessed with the Short Form 36-Item Health Survey in hemodialysis patients. METHODS: In total, 101 patients (57 females) with ESKD were recruited from two Romanian dialysis centers...
July 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28314578/anticoagulation-atrial-fibrillation-and-chronic-kidney%C3%A2-disease-whose-side%C3%A2-are-you-on
#13
Gunnar Henrik Heine, Vincent Brandenburg
Whether to initiate oral anticoagulant therapy in advanced chronic kidney disease patients with atrial fibrillation remains debatable. Although randomized trial data are lacking, observational studies yield controversial results. Keskar and colleagues analyzed data from a Canadian health care system and found that in elderly chronic kidney disease patients with atrial fibrillation, oral anticoagulant therapy did not prevent ischemic strokes, induced hemorrhages, but prolonged life. These paradoxical findings emphasize the dire need for an adequately powered randomized trial...
April 2017: Kidney International
https://www.readbyqxmd.com/read/28196649/diabetes-control-and-the-risks-of-esrd-and-mortality-in%C3%A2-patients%C3%A2-with-ckd
#14
Sankar D Navaneethan, Jesse D Schold, Stacey E Jolly, Susana Arrigain, Wolfgang C Winkelmayer, Joseph V Nally
BACKGROUND: Diabetes is the leading cause of end-stage renal disease (ESRD) and a significant contributor to mortality in the general population. We examined the associations of hemoglobin A1c (HbA1c) levels with ESRD and death in a population with diabetes and chronic kidney disease (CKD). STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: 6,165 patients with diabetes (treated with oral hypoglycemic agents and/or insulin) and CKD stages 1 to 5 at a large health care system...
February 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28110688/intradialytic-creatine-supplementation-a-scientific-rationale-for-improving-the-health-and-quality-of-life-of-dialysis-patients
#15
Theo Wallimann, Uwe Riek, Michael Möddel
The CK/PCr-system, with creatine (Cr) as an energy precursor, plays a crucial role in cellular physiology. In the kidney, as in other organs and cells with high and fluctuating energy requirements, energy-charged phospho-creatine (PCr) acts as an immediate high-energy source and energy buffer, and as an intracellular energy transport vehicle. A maximally filled total Cr (Cr plus PCr) pool is a prerequisite for optimal functioning of the body and its organs, and health. Skeletal- and cardiac muscles of dialysis patients with chronic kidney disease (CKD) are depleted of Cr in parallel with the duration of dialysis...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/27834801/trimethylamine-n-oxide-the-good-the-bad-and-the-unknown
#16
REVIEW
Manuel T Velasquez, Ali Ramezani, Alotaibi Manal, Dominic S Raj
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea. Plasma level of TMAO is determined by a number of factors including diet, gut microbial flora and liver flavin monooxygenase activity. In humans, a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events and death is reported...
November 8, 2016: Toxins
https://www.readbyqxmd.com/read/27613897/protective-effect-of-nicotine-on-sepsis-induced-oxidative-multiorgan-damage-role-of-neutrophils
#17
Zarife N Özdemir-Kumral, Dilek Özbeyli, Ahmet F Özdemir, Bugra M Karaaslan, Kübra Kaytaz, Mustafa F Kara, Olgu E Tok, Feriha Ercan, Berrak Ç Yegen
Introduction: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. Methods: Male Wistar albino rats received tap water with (5mg/kg) or without nicotine for 14 days. Under ketamine anesthesia, sepsis (n = 50) was induced by ligation and puncture of the cecum, while sham group (n = 8) had only laparotomy...
July 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27599981/impact-of-the-use-of-anti-diabetic-drugs-on-survival-of-diabetic-dialysis-patients-a-5-year-retrospective-cohort-study-in-taiwan
#18
Po-Jen Hsiao, Kun-Lin Wu, Szu-Han Chiu, Jenq-Shyong Chan, Yuh-Feng Lin, Chung-Ze Wu, Chia-Chao Wu, SenYeong Kao, Te-Chao Fang, Shih-Hua Lin, Jin-Shuen Chen
BACKGROUND: Type 2 diabetes mellitus (DM) and associated complications are common in patients with chronic kidney disease (CKD) and can increase morbidity and mortality. A longitudinal 5-year observational study was conducted to investigate whether the use of anti-diabetic medications or not affected survival rates of diabetic dialysis patients. METHODS: Using a data sample of a million patients from Taiwan's National Health Insurance Database, a retrospective cohort study surveyed patients with type 2 DM who began dialysis between 2002 and 2007...
September 6, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27549687/potential-effect-of-substituting-estimated-glomerular-filtration-rate-for-estimated-creatinine-clearance-for-dosing-of-direct-oral-anticoagulants
#19
Janice B Schwartz
OBJECTIVES: To determine the potential effect of substituting glomerular filtration rate (GFR) estimates for renal clearance estimated using the Cockcroft-Gault method (CrCL-CG) to calculate direct oral anticoagulant (DOAC) dosing. DESIGN: Simulation and retrospective data analysis. SETTING: Community, academic institution, nursing home. PARTICIPANTS: Noninstitutionalized individuals aged 19 to 80 from the National Health and Nutrition Examination Survey (NHANES) (2011/12) (n = 4,687) and medically stable research participants aged 25 to 105 (n = 208)...
October 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27540596/grazoprevir-elbasvir-fixed-dose-combination-for-hepatitis-c
#20
REVIEW
N Gamal, P Andreone
Hepatitis C virus (HCV) infection is an increasing public health concern with an estimated 184 million people infected worldwide and approximately 350,000 deaths yearly from HCV-related complications. There is a compelling medical need for new anti-HCV therapeutic agents that are potent, tolerable, safe, completely oral and with shorter treatment duration. To this end, a plethora of direct-acting antivirals have been developed and regulatory authorities have approved nine new molecules for the treatment of chronic hepatitis C (CHC)...
July 2016: Drugs of Today
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