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oral health and chronic kidney disease

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https://www.readbyqxmd.com/read/29209440/efficacy-of-fenugreek-based-bionanocomposite-on-renal-dysfunction-and-endogenous-intoxication-in-high-calorie-diet-induced-obesity-rat-model-comparative-study
#1
Victoria V Konopelniuk, Ievgenii I Goloborodko, Tetyana V Ishchuk, Tetyana B Synelnyk, Ludmila I Ostapchenko, Mykola Ya Spivak, Rostyslav V Bubnov
Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29181788/mortality-associated-with-metformin-versus-sulfonylurea-initiation-a-cohort-study-of-veterans-with-diabetes-and-chronic-kidney-disease
#2
Zachary A Marcum, Christopher W Forsberg, Kathryn P Moore, Ian H de Boer, Nicholas L Smith, Edward J Boyko, James S Floyd
BACKGROUND: For patients with type 2 diabetes and chronic kidney disease (CKD), high-quality evidence about the relative benefits and harms of oral glucose-lowering drugs is limited. OBJECTIVE: To evaluate whether mortality risk differs after the initiation of monotherapy with either metformin or a sulfonylurea in Veterans with type 2 diabetes and CKD. DESIGN: Observational, national cohort study in the Veterans Health Administration (VHA)...
November 27, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29123429/assessment-of-prescribed-medications-and-pattern-of-distribution-for-potential-drug-drug-interactions-among-chronic-kidney-disease-patients-attending-the-nephrology-clinic-of-lagos-university-teaching-hospital-in-sub-saharan-west-africa
#3
Olumuyiwa John Fasipe, Peter Ehizokhale Akhideno, Obiyo Nwaiwu, Alex Adedotun Adelosoye
Introduction: Life expectancy has increased significantly among chronic kidney disease (CKD) patients due to the extensive use of polypharmacy practice for medication prescriptions. This predisposes them to potential drug-drug interactions (DDIs), which can lead to an increase in morbidity, mortality, length of hospital stay, and health care cost. Methods: This was a 30-month retrospective study that reviewed the medical case records of consenting adult CKD patients from January 2014 to June 2016...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29099363/the-effects-of-oral-health-on-systemic-health
#4
Shawn F Kane
The oral cavity is the intersection of medicine and dentistry and the window into the general health of a patient. Hundreds of diseases and medications impact the oral cavity, and pathologic conditions in the mouth have a greater systemic impact than many providers appreciate. It is unclear whether there is true causality or just an association between periodontal disease and certain other systemic conditions, including atherosclerotic vascular disease, pulmonary disease, diabetes, pregnancy-related complications, osteoporosis, and kidney disease...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29080863/temporal-trends-in-the-use-and-comparative-effectiveness-of-direct-oral-anticoagulant-agents-versus-warfarin-for-nonvalvular-atrial-fibrillation-a-canadian-population-based-study
#5
Amy Y X Yu, Shaun Malo, Lawrence W Svenson, Stephen B Wilton, Michael D Hill
BACKGROUND: Direct oral anticoagulants (DOACs) are noninferior to warfarin for stroke prevention in atrial fibrillation (AF). We aimed to determine the population risk of stroke and death in incident AF, stratified by anticoagulation status and type, and the temporal trends of oral anticoagulation practice in the post-DOAC approval period. METHODS AND RESULTS: We conducted a population-based cohort study of incident nonvalvular AF cases using administrative health data in Alberta, Canada...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29068572/the-assessment-of-prosthetic-needs-of-esrd-patients-and-the-general-population-in-poland-on-the-basis-of-the-eichner-classification-and-teeth-number-a-brief-preliminary-report
#6
Marta Miernik, Katarzyna Madziarska, Marian Klinger, Wacław Weyde, Włodzimierz Więckiewicz
BACKGROUND: End-stage renal disease (ESRD) patients are considered as a group of high risk of oral cavity diseases. One of the determinants of alveolar bone loss and increased teeth mobility in ESRD patients might be the bone abnormalities associated with chronic kidney disease-mineral and bone disorder (CKD-MBD). OBJECTIVES: The aim of the study was to compare the general health condition, number and location of teeth in a group of ESRD patients with the group of peers from general population and revealing the risk factors of tooth loss...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29033594/cost-effectiveness-analysis-of-intravenous-ferumoxytol-for-the-treatment-of-iron-deficiency-anemia-in-adult-patients-with-non-dialysis-dependent-chronic-kidney-disease-in-the-usa
#7
Naomi V Dahl, Robert F Kaper, William E Strauss, Frank A Corvino, Marko Zivkovic
OBJECTIVE: Ferumoxytol has demonstrated superior efficacy compared with oral iron in treating iron deficiency anemia in chronic kidney disease (CKD) patients. However, an economic evaluation of ferumoxytol has not been conducted. The aim of this study was to analyze the cost-effectiveness of treating iron deficiency anemia in adult non-dialysis-dependent CKD patients with ferumoxytol as compared with oral iron, alone or in combination with erythropoietin-stimulating agents (ESAs). METHODS: A decision analytic model compared health outcomes and costs associated with 5-week outpatient treatment of adult non-dialysis-dependent CKD patients with ferumoxytol or oral iron, each as monotherapy or in combination with ESAs in the USA...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28984052/patterns-of-long-term-use-of-non-vitamin-k-antagonist-oral-anticoagulants-for-non-valvular-atrial-fibrillation-quebec-observational-study
#8
Antonios Douros, Christel Renoux, Janie Coulombe, Samy Suissa
PURPOSE: Studies on long-term utilization of non-vitamin K antagonist oral anticoagulants (NOACs) in non-valvular atrial fibrillation (NVAF) are scarce. We evaluated predictors of use and long-term persistence of NOACs in a real-world setting. METHODS: This population-based cohort study used the computerized databases of the Canadian Province of Quebec's health insurance. Patients with a first NVAF diagnosis from 2011 until 2014 were included. A logistic regression model yielded adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for predictors of treatment initiation with NOACs versus VKAs...
October 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28937069/oral-health-in-diabetic-and-nondiabetic-patients-with-chronic-kidney-disease
#9
Lingam Amara Swapna, Pradeep Koppolu, Jyothi Prince
The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Subjective and objective findings were evaluated and recorded in the specially designed pro forma...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28873225/chronic-hepatitis-c-increases-the-risk-of-chronic-kidney-disease-ckd-while-effective-hcv-treatment-decreases-the-incidence-of-ckd
#10
Haesuk Park, Chao Chen, Wei Wang, Linda Henry, Robert L Cook, David R Nelson
We aimed to assess the risk of chronic kidney disease (CKD) in chronic hepatitis C virus (HCV) infected patients and the incidence reduction of CKD after receipt of HCV treatment. We also evaluated the risk of membranoproliferative glomerulonephritis (MPGN) and cryoglobulinemia in chronic HCV patients. A retrospective cohort analysis of the Truven Health MarketScan Database (2008-2015) in the United States was conducted. In a cohort of 56,448 HCV-infected patients and propensity score (1:3) matched 169,344 non-HCV patients, we examined the association of HCV infection with the incidence of CKD...
September 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28856671/direct-oral-anticoagulant-medications-in-calciphylaxis
#11
Brian J King, Rokea A El-Azhary, Marian T McEvoy, Raymond C Shields, Robert D McBane, James T McCarthy, Mark D P Davis
BACKGROUND: Recent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis. Our objective is to report the use of oral direct thrombin and factor Xa inhibitors (termed direct oral anticoagulants [DOACs]) in patients with calciphylaxis. METHODS: We retrospectively reviewed records of 16 patients with calciphylaxis who received concomitant administration of novel anticoagulants...
October 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28856009/the-chronic-kidney-disease-water-intake-trial-protocol-of-a-randomized-controlled-trial
#12
William F Clark, Shih-Han Huang, Amit X Garg, Kerri Gallo, Andrew A House, Louise Moist, Matthew A Weir, Jessica M Sontrop
BACKGROUND: In observational studies, drinking more water associates with a slower rate of kidney function decline; whether the same is true in a randomized controlled trial is unknown. OBJECTIVE: To examine the 1-year effect of a higher vs usual water intake on estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease. DESIGN: Parallel-group randomized controlled trial. SETTING: Nine centers in Ontario, Canada...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28846062/association-of-the-salivary-triggering-receptor-expressed-on-myeloid-cells-its-ligand-peptidoglycan-recognition-protein-1-axis-with-oral-inflammation-kidney-disease
#13
Karita M Nylund, Hellevi Ruokonen, Timo Sorsa, Anna Maria Heikkinen, Jukka H Meurman, Fernanda Ortiz, Taina Tervahartiala, Jussi Furuholm, Nagihan Bostanci
BACKGROUND: Triggering Receptor Expressed on Myeloid Cells (TREM-1) is a cell-surface receptor involved in amplification of inflammatory response to bacterial infections, along with its ligand peptidoglycan recognition protein 1 (PGLYRP1). TREM-1 is shed by matrix metalloproteinases (MMPs) to its soluble (s) form. The aim of the study was to investigate association of sTREM-1 and PGLYRP1 with oral inflammatory burden among chronic kidney disease (CKD) patients at predialysis and post-transplantation stages...
August 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28767915/evaluation-of-periodontal-condition-and-risk-in-patients-with-chronic-kidney-disease-on-hemodialysis
#14
Yeon Jung Kim, Luciana Martins de Moura, Christiane Peres Caldas, Caroline Perozini, Gilson Fernandes Ruivo, Debora Pallos
Objective: To establish a profile of periodontal conditions in chronic kidney disease patients on hemodialysis and their periodontal risk. Methods: We included 115 patients on hemodialysis. Clinical periodontal parameters assessed were: plaque index, gingival index, probing depth and clinical attachment level. Patients were classified according to presence/absence and severity of periodontal disease and periodontal risk. Results: In 107 dentate patients (93%) the plaque index was 1...
April 2017: Einstein
https://www.readbyqxmd.com/read/28762362/prevalence-and-pattern-of-potential-drug-drug-interactions-among-chronic-kidney-disease-patients-in-south-western-nigeria
#15
J Fasipe Olumuyiwa, A Akinbodewa Akinwumi, O Adejumo Ademola, B Akawa Oluwole, E Okaka Ibiene
BACKGROUND: Management of chronic kidney disease (CKD) patients often requires the use of multiple drugs due to a high number of cardiovascular risk factors and complications associated with the disease. Multiple drugs predispose to potential drug-drug interactions (DDIs) which may be associated with increased morbidity, mortality, length of hospital stay and health-care cost. OBJECTIVES: This study determined the prevalence and pattern of potential DDIs among CKD patients attending Kidney Care Centre, in Ondo City, Nigeria...
April 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28726185/raising-awareness-on-the-therapeutic-role-of-cholecalciferol-in-ckd-a-multidisciplinary-based-opinion
#16
REVIEW
Sandro Giannini, Sandro Mazzaferro, Salvatore Minisola, Luca De Nicola, Maurizio Rossini, Mario Cozzolino
Vitamin D is recognized to play an essential role in health and disease. In kidney disease, vitamin D analogs have gained recognition for their involvement and potential therapeutic importance. Nephrologists are aware of the use of oral native vitamin D supplementation, however, uncertainty still exists with regard to the use of this treatment option in chronic kidney disease as well as clinical settings related to chronic kidney disease, where vitamin D supplementation may be an appropriate therapeutic choice...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28700482/beneficial-effects-of-fu-zheng-qu-zhuo-oral-liquid-combined-with-standard-integrated-therapy-in-patients-with-chronic-kidney-disease-stage-3-4-a-randomized-placebo-controlled-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Shen Li, Xiang-Rong Rao, Xi-Wen Dai, Kun Pei, Lee Wang, Bao-Min Huo, Xiu-Juan Wang, Ling-Xin Kong, Nan-Nan Zhang, Feng-Mei Lian
BACKGROUND: The high worldwide prevalence of chronic kidney disease (CKD) is a critical health problem and the development of more effective therapies is urgently needed. We conducted a randomized, double-blinded, placebo-controlled clinical trial from October 2010 to December 2012 to assess whether Fu-Zheng-Qu-Zhuo oral liquid (FZQZ) has a beneficial effect in preventing CKD progression when added to standard integrated therapies. METHODS: Patients with CKD stage 3 to 4 from 3 hospitals in Beijing, China were enrolled...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28644432/dental-implant-treatment-for-renal-failure-patients-on-dialysis-a-clinical-guideline
#18
REVIEW
Quan Yuan, Qiu-Chan Xiong, Megha Gupta, Rosa María López-Pintor, Xiao-Lei Chen, Dutmanee Seriwatanachai, Michael Densmore, Yi Man, Ping Gong
Chronic kidney disease (CKD) is a worldwide public health problem that is growing in prevalence and is associated with severe complications. During the progression of the disease, a majority of CKD patients suffer oral complications. Dental implants are currently the most reliable and successful treatment for missing teeth. However, due to complications of CKD such as infections, bone lesions, bleeding risks, and altered drug metabolism, dental implant treatment for renal failure patients on dialysis is more challenging...
September 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28576451/elbasvir-plus-grazoprevir-in-patients-with-hepatitis-c-virus-infection-and-stage-4-5-chronic-kidney-disease-clinical-virological-and-health-related-quality-of-life-outcomes-from-a-phase-3-multicentre-randomised-double-blind-placebo-controlled-trial
#19
Annette Bruchfeld, David Roth, Paul Martin, David R Nelson, Stanislas Pol, Maria-Carlota Londoño, Howard Monsour, Marcelo Silva, Peggy Hwang, Jean-Marie Arduino, Michael Robertson, Bach-Yen Nguyen, Janice Wahl, Eliav Barr, Wayne Greaves
BACKGROUND: In the C-SURFER study, therapy with the all-oral elbasvir plus grazoprevir regimen for 12 weeks in patients with chronic hepatitis C virus (HCV) infection and stage 4-5 chronic kidney disease resulted in a high rate of virological cure compared with placebo. Here, we report sustained virological response (SVR), safety data, health-related quality-of-life (HRQOL), and virological resistance analyses in patients in C-SURFER who received immediate antiviral therapy or who received placebo before therapy...
August 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28532432/periodontitis-and-early-mortality-among-adults-treated-with-hemodialysis-a-multinational-propensity-matched-cohort-study
#20
Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok, Paul Stroumza, Anna Bednarek-Skublewska, Jan Dulawa, Luc Frantzen, Domingo Del Castillo, Staffan Schon, Amparo G Bernat, Jorgen Hegbrant, Charlotta Wollheim, Letizia Gargano, Casper P Bots, Giovanni Fm Strippoli
BACKGROUND: Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney failure. METHODS: ORAL-D was a propensity matched analysis in 3338 dentate adults with end-stage kidney disease treated in a hemodialysis network in Europe and South America designed to examine the association between periodontitis and all-cause and cardiovascular-related mortality in people on long-term hemodialysis...
May 22, 2017: BMC Nephrology
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