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oral health and chronic kidney disease

Zarife Nigâr Özdemir-Kumral, Dilek Özbeyli, Ahmet Faruk Özdemir, M Buğra Karaaslan, Kübra Kaytaz, Mustafa F Kara, Olgu Enis Tok, Feriha Ercan, Berrak Ç Yeğen
INTRODUCTION: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. METHODS: Male Wistar albino rats received tap water with (5 mg/kg) or without nicotine for 14 days. Under ketamine anesthesia, sepsis (n=50) was induced by ligation and punction of the cecum, while sham group (n=8) had only laparotomy...
August 3, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Po-Jen Hsiao, Kun-Lin Wu, Szu-Han Chiu, Jenq-Shyong Chan, Yuh-Feng Lin, Chung-Ze Wu, Chia-Chao Wu, SenYeong Kao, Te-Chao Fang, Shih-Hua Lin, Jin-Shuen Chen
BACKGROUND: Type 2 diabetes mellitus (DM) and associated complications are common in patients with chronic kidney disease (CKD) and can increase morbidity and mortality. A longitudinal 5-year observational study was conducted to investigate whether the use of anti-diabetic medications or not affected survival rates of diabetic dialysis patients. METHODS: Using a data sample of a million patients from Taiwan's National Health Insurance Database, a retrospective cohort study surveyed patients with type 2 DM who began dialysis between 2002 and 2007...
September 6, 2016: Clinical and Experimental Nephrology
Janice B Schwartz
OBJECTIVES: To determine the potential effect of substituting glomerular filtration rate (GFR) estimates for renal clearance estimated using the Cockcroft-Gault method (CrCL-CG) to calculate direct oral anticoagulant (DOAC) dosing. DESIGN: Simulation and retrospective data analysis. SETTING: Community, academic institution, nursing home. PARTICIPANTS: Noninstitutionalized individuals aged 19 to 80 from the National Health and Nutrition Examination Survey (NHANES) (2011/12) (n = 4,687) and medically stable research participants aged 25 to 105 (n = 208)...
August 22, 2016: Journal of the American Geriatrics Society
N Gamal, P Andreone
Hepatitis C virus (HCV) infection is an increasing public health concern with an estimated 184 million people infected worldwide and approximately 350,000 deaths yearly from HCV-related complications. There is a compelling medical need for new anti-HCV therapeutic agents that are potent, tolerable, safe, completely oral and with shorter treatment duration. To this end, a plethora of direct-acting antivirals have been developed and regulatory authorities have approved nine new molecules for the treatment of chronic hepatitis C (CHC)...
July 2016: Drugs of Today
Hellevi Ruokonen, Karita Nylund, Jussi Furuholm, Jukka H Meurman, Timo Sorsa, Karoliina Kotaniemi, Fernanda Ortiz, Anna Maria Heikkinen
OBJECTIVES: We investigated factors related to the mortality of patients with chronic kidney disease to find out whether oral disease inflammatory burden or different diagnosis of chronic kidney disease could be associated with mortality. MATERIAL AND METHODS: This prospective cohort study comprised 144 adults at the predialysis stage. Clinical oral and radiological examination was made during the years 2000 - 2005. The patients were then followed up until August 2015 (complete follow-up time 157 months)...
August 13, 2016: Journal of Periodontology
David C Ford, Naomi V Dahl, William E Strauss, Charles F Barish, David J Hetzel, Kristine Bernard, Zhu Li, Lee F Allen
INTRODUCTION: Iron deficiency anemia (IDA) is common in patients with gastrointestinal (GI) disorders and can adversely affect quality of life. Oral iron is poorly tolerated in many patients with GI disorders. Ferumoxytol is approved for the intravenous treatment of IDA in patients with chronic kidney disease. This study aimed to evaluate the efficacy and safety of ferumoxytol in patients with IDA and concomitant GI disorders. PATIENTS AND METHODS: This analysis included 231 patients with IDA and GI disorders from a Phase III, randomized, double-blind, placebo-controlled trial evaluating ferumoxytol (510 mg ×2) versus placebo in patients who had failed or were intolerant of oral iron therapy...
2016: Clinical and Experimental Gastroenterology
Graham A Colditz, Sydney E Philpott, Susan E Hankinson
OBJECTIVES: To summarize the overall impact of the Nurses' Health Study (NHS) over the past 40 years on the health of populations through its contributions on prevention, translation, and control. METHODS: We performed a narrative review of the findings of the NHS, NHS II, and NHS3 between 1976 and 2016. RESULTS: The NHS has generated significant findings about the associations between (1) smoking and type 2 diabetes, cardiovascular diseases, colorectal and pancreatic cancer, psoriasis, multiple sclerosis, and eye diseases; (2) physical activity and cardiovascular diseases, breast cancer, psoriasis, and neurodegeneration; (3) obesity and cardiovascular diseases, numerous cancer sites, psoriasis, multiple sclerosis, kidney stones, and eye diseases; (4) oral contraceptives and cardiovascular disease, melanoma, and breast, colorectal, and ovarian cancer; (5) hormone therapy and cardiovascular diseases, breast and endometrial cancer, and neurodegeneration; (6) endogenous hormones and breast cancer; (7) dietary factors and type 2 diabetes, cardiovascular diseases, breast and pancreatic cancer, non-Hodgkin's lymphoma, neurodegeneration, multiple sclerosis, kidney stones, and eye diseases; and (8) sleep and shift work and chronic diseases...
September 2016: American Journal of Public Health
Yu-Ching Chen, Charles Tzu-Chi Lee, Boniface J Lin, Yong-Yuan Chang, Hon-Yi Shi
BACKGROUND: The impact of pay-for-performance (P4P) programs on long-term mortality for chronic illnesses, especially diabetes mellitus, has been rarely reported. Several studies described the favorable impact of P4P for diabetes mellitus on medical utilizations or intermediate outcomes. Therefore, this study aimed to investigate the impact of a P4P program on mortality in patients with type 2 diabetes. METHODS: The P4P group in this population-based cohort study was 2090 individuals with a primary diagnosis of type 2 diabetes who had been newly enrolled in the P4P program of Taiwan between January 1, 2004 and December 31, 2004...
July 2016: Medicine (Baltimore)
Mathieu Legendre, Hervé Devilliers, Laurent Perard, Matthieu Groh, Habdelamid Nefti, Bertrand Dussol, Salim Trad, Fatouma Touré, Sébastien Abad, Jean-Jacques Boffa, Luc Frimat, Stéphane Torner, Alexandre Seidowsky, Ziad André Massy, David Saadoun, Virginie Rieu, Yoland Schoindre, Emmanuel Heron, Thierry Frouget, Arnaud Lionet, François Glowacki, Laurent Arnaud, Christiane Mousson, Jean-François Besancenot, Jean-Michel Rebibou, Philip Bielefeld
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, defined by the association of idiopathic acute TINU. The aim of our work was to determine the characteristics of adult TINU syndrome in France, and to assess factors (including treatment) influencing medium-term prognosis.We conducted a nationwide study including 20 French hospitals. Clinical, laboratory, and renal histopathologic data of 41 biopsy-proven TINU syndromes were retrospectively collected. The patients were diagnosed between January 1, 1999 and December 1, 2015...
June 2016: Medicine (Baltimore)
Florence Carrouel, Stéphane Viennot, Julie Santamaria, Philippe Veber, Denis Bourgeois
In oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. The interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. This PCR study is the first to describe the interdental microbiota in healthy adults aged 18-35 years-old with reference to the Socransky complexes...
2016: Frontiers in Microbiology
Qian-Rong Xiao, Li-Jun Fan, Wei Jiang, De-Fu Zhao, Heng Wan, Dao-Yan Pan, Xu Lin, Tong Zhang, Jie Shen
OBJECTIVE: To investigate the prevalence of chronic kidney disease (CKD) in subjects with different glucose metabolism status. METHODS: Between January, 2015 and October, 2015, a total of 934 subjects without a previous diagnosis of diabetes visiting the Department of Endocrinology or Health Examination Center underwent oral glucose tolerance test (OGTT), which identified 266 subjects with normal glucose tolerance (NGT group), 243 pre-diabetic subjects, and 425 patients with diabetes mellitus group...
May 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Vera Krane, Christoph Wanner
No abstract text is available yet for this article.
October 2016: Nephrology, Dialysis, Transplantation
Sofia B Ahmed, Sharanya Ramesh
Menstrual disorders, infertility and premature menopause are common but often underrecognized phenomena among women with chronic kidney disease. Hypothalamic, rather than ovarian dysfunction, may be the cause of the abnormal reproductive milieu, which can be at least partially reversed by kidney transplantation and increased intensity of hemodialysis. Endogenous sex hormones, and specifically estradiol, appear to be renoprotective in women, although the effects of exogenous estradiol (as an oral contraceptive and postmenopausal hormone therapy) on kidney function are more controversial...
May 4, 2016: Nephrology, Dialysis, Transplantation
Suetonia C Palmer, Marinella Ruospo, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok, Paul Stroumza, Luc Frantzen, Anna Bednarek-Skublewska, Jan Dulawa, Domingo Del Castillo, Amparo G Bernat, Jorgen Hegbrant, Charlotta Wollheim, Staffan Schon, Letizia Gargano, Casper P Bots, Giovanni F M Strippoli
BACKGROUND: Oral disease is a potentially treatable determinant of mortality and quality of life. No comprehensive multinational study to quantify oral disease burden and to identify candidate preventative strategies has been performed in the dialysis setting. METHODS: The ORAL disease in hemoDialysis (ORALD) study was a prospective study in adults treated with hemodialysis in Europe (France, Hungary, Italy, Poland, Portugal and Spain) and Argentina. Oral disease was assessed using standardized WHO methods...
October 2016: Nephrology, Dialysis, Transplantation
Seo Hyon Baik, Inmaculada Hernandez, Yuting Zhang
BACKGROUND: As alternatives to warfarin, 2 novel oral anticoagulants (NOACs), dabigatran and rivaroxaban, were approved in 2010 and 2011 to prevent stroke and other thromboembolic events in patients with atrial fibrillation. It is unclear how patient characteristics are associated with the initiation of anticoagulants. OBJECTIVE: To evaluate how patient demographics, clinical characteristics, types of insurance, and patient out-of-pocket spending affect the initiation of warfarin and 2 NOACs--dabigatran and rivaroxaban...
March 2016: Journal of Managed Care & Specialty Pharmacy
Cheryl A Sadowski, Catherine Lyder, Nesé Yuksel
BACKGROUND: Clinicians often face challenges in deciding how to treat osteoporosis in patients with chronic kidney disease. As background to offering guidance to health care providers, it is important to understand their practices and beliefs. OBJECTIVES: To describe the practices and beliefs of pharmacists regarding use of bisphosphonates for patients with osteoporosis and chronic kidney disease. METHODS: A cross-sectional survey of pharmacists working in hospitals and related health care settings was conducted...
January 2016: Canadian Journal of Hospital Pharmacy
Chenlin Yu, Ziteng Zhang, Yangang Liu, Ying Zong, Yongchun Chen, Xiuming Du, Jikuai Chen, Shijie Feng, Jinlian Hu, Shufang Cui, Guocai Lu
The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access the toxicity of ST. This experiment presents data from 184-day toxicology studies in Sprague-Dawley (SD) rats designed to characterize the chronic effects of a smokeless tobacco extract (STE). The control group and treatment groups were matched for a range of nicotine levels...
March 2016: International Journal of Environmental Research and Public Health
Batoul Ahmadi, Masoomeh Alimohammadian, Mehdi Yaseri, Azam Majidi, Majid Boreiri, Farhad Islami, Hossein Poustchi, Mohammad H Derakhshan, Akabar Feizesani, Akram Pourshams, Christian C Abnet, Paul Brennan, Sanford M Dawsey, Farin Kamangar, Paolo Boffetta, Alireza Sadjadi, Reza Malekzadeh
Advances in medicine and health policy have resulted in growing of older population, with a concurrent rise in multimorbidity, particularly in Iran, as a country transitioning to a western lifestyle, and in which the percent of the population over the age of 60 years is increasing. This study aims to assess multimorbidity and the associated risk factors in Iran. We used data from 50,045 participants (age 40-75 y) in the Golestan Cohort Study, including data on demographics, lifestyle habits, socioeconomic status, and anthropometric indices...
February 2016: Medicine (Baltimore)
Carolina C R Betônico, Silvia M O Titan, Maria Lúcia C Correa-Giannella, Márcia Nery, Márcia Queiroz
The purpose of this study was to evaluate the therapeutic options for diabetes treatment and their potential side effects, in addition to analyzing the risks and benefits of tight glycemic control in patients with diabetic kidney disease. For this review, a search was performed using several pre-defined keyword combinations and their equivalents: "diabetes kidney disease" and "renal failure" in combination with "diabetes treatment" and "oral antidiabetic drugs" or "oral hypoglycemic agents." The search was performed in PubMed, Endocrine Abstracts and the Cochrane Library from January 1980 up to January 2015...
January 2016: Clinics
Jeongho Park, Craig J Goergen, Harm HogenEsch, Chang H Kim
Short-chain fatty acids (SCFAs) are major products of gut microbial fermentation and profoundly affect host health and disease. SCFAs generate IL-10(+) regulatory T cells, which may promote immune tolerance. However, SCFAs can also induce Th1 and Th17 cells upon immunological challenges and, therefore, also have the potential to induce inflammatory responses. Because of the seemingly paradoxical SCFA activities in regulating T cells, we investigated, in depth, the impact of elevated SCFA levels on T cells and tissue inflammation in mice...
March 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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