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Francine O James, Lauren B Waggoner, Patricia M Weiss, P Daniel Patterson, J Stephen Higgins, Eddy S Lang, Hans P A Van Dongen
BACKGROUND: Work schedules like those of Emergency Medical Services (EMS) personnel have been associated with increased risk of fatigue-related impairment. Biomathematical modeling is a means of objectively estimating the potential impacts of fatigue on performance, which may be used in the mitigation of fatigue-related safety risks. In the context of EMS operations, our objective was to assess the evidence in the literature regarding the effectiveness of using biomathematical models to help mitigate fatigue and fatigue-related risks...
January 11, 2018: Prehospital Emergency Care
Olcay Akman, Timothy D Comar, Daniel Hrozencik
In [X. Song and Z. Xiang, 2006. The prey-dependent consumption two-prey one-predator models with stage structure for the predator and impulsive effects. Journal of Theoretical Biology, 242, 683-698.], an integrated pest management model with periodically varying climatic conditions was introduced. In order to address a wider range of environmental effects, the authors here have embarked upon a series of studies resulting in a more flexible modeling approach. In [O. Akman, T.D. Comar, and D. Hrozencik, 2013...
December 11, 2017: Journal of Theoretical Biology
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
January 2018: Cancer Treatment Reviews
Ying-Hwey Nai, Miho Shidahara, Chie Seki, Hiroshi Watabe
Introduction: To facilitate radiotracers' development, a screening methodology using a biomathematical model and clinical usefulness index (CUI) was proposed to evaluate radiotracers' diagnostic capabilities. Methods: A total of 31 amyloid positron emission tomography radiotracers were evaluated. A previously developed biomathematical model was used to simulate 1000 standardized uptake value ratios with population and noise simulations, which were used to determine the integrated receiver operating characteristics curve (Az), effect size (Es), and standardized uptake value ratio (Sr) of conditions-pairs of healthy control-mild cognitive impaired and mild cognitive impaired-Alzheimer's disease...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Sofiane Bendifallah, Marcos Ballester, Emile Daraï
In France, in 2015, endometrial cancer (CE) is the first gynecological cancer in terms of incidence and the fourth cause of cancer of the woman. About 8151 new cases and nearly 2179 deaths have been reported. Treatments (surgery, external radiotherapy, brachytherapy and chemotherapy) are currently delivered on the basis of an estimation of the recurrence risk, an estimation of lymph node metastasis or an estimate of survival probability. This risk is determined on the basis of prognostic factors (clinical, histological, imaging, biological) taken alone or grouped together in the form of classification systems, which are currently insufficient to account for the evolutionary and prognostic heterogeneity of endometrial cancer...
December 2017: Bulletin du Cancer
Plamen L Simeonov
The goal of this paper is to advance an extensible theory of living systems using an approach to biomathematics and biocomputation that suitably addresses self-organized, self-referential and anticipatory systems with multi-temporal multi-agents. Our first step is to provide foundations for modelling of emergent and evolving dynamic multi-level organic complexes and their sustentative processes in artificial and natural life systems. Main applications are in life sciences, medicine, ecology and astrobiology, as well as robotics, industrial automation, man-machine interface and creative design...
December 2017: Bio Systems
David Alimi, Jacques E Chelly
OBJECTIVES: To propose at the auriculotherapists a New Universal Nomenclature of Auriculotherapy, able to receive any mapping whatsoever. DESIGN: We built this proposition by using electronic database search to find the different formulations of Auricular Acupuncture Points (AAPs), by studying neuroradiology methods describing reliable and reproducible marks able to adapt to all brain morphologies, by studying the analysis of brain dissections, showed us the internal organization of the brain; and after having proved the neurophysiological correlations between auricular displays and their brain correspondences...
August 23, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Hugo A Van Den Berg
Mathematical biology occupies a special place at the interface between the physical, mathematical and life sciences. Is this interface merely a meeting point for dabblers venturing out of their own proper domains to work on problems of mutual interest? Or is it an incipient science in its own right, with its own particular character, principles, and practices? The past century has seen vast advances in the application of mathematical and physical ideas and techniques to biological problems, in the process transforming many of them almost beyond recognition...
March 1, 2017: Science Progress
Michael C Worlicek, Michael L Wörner, Benjamin S Craiovan, Florian Zeman, Joachim Grifka, Tobias F Renkawitz, Markus Weber
BACKGROUND: Assessing femoral version in orthopedic surgery is important for preoperative planning of total hip arthroplasty, especially for recognizing excessive anteversion or retroversion. The present study addressed the following: (1) Is the position of the lesser trochanter correlated to the femoral neck axis? (2) If so, may femoral version be assessed by means of plain pelvic radiographs? METHODS: Three-dimensional computed tomography scans of 60 patients undergoing minimally invasive cement-free total hip arthroplasty were retrospectively analyzed, particularly with regard to the relation between the femoral neck axis and the lesser trochanter, the femoral version, and the size of the projected lesser trochanter in different rotational positions...
September 2017: Journal of Arthroplasty
Malgorzata Domino, Bartosz Pawlinski, Zdzislaw Gajewski
Uterine contractions are generated by myometrial smooth muscle cells (SMCs) that comprise most of the myometrial layer of the uterine wall. Aberrant uterine motility (i.e., hypo- or hyper-contractility or asynchronous contractions) has been implicated in the pathogenesis of infertility due to the failure of implantation, endometriosis and abnormal estrous cycles. The mechanism whereby the non-pregnant uterus initiates spontaneous contractions remains poorly understood. The aim of the present study was to employ linear synchronization measures for analyzing the pattern of EMG signal propagation (direction and speed) in smooth muscles of the non-pregnant porcine uterus in vivo using telemetry recording system...
2017: PloS One
Hans P Zenner
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Hector Gomez
Hypoxia is a hallmark of gliomas that is often associated with poor prognosis and resistance to therapies. Insufficient oxygen supply reduces the proliferation rate of tumor cells, which contributes to a slower progression of the lesion, but also increases the invasiveness of the tumor, making it more aggressive. To understand how these two counteracting mechanisms combine and modify the tumor's global growth, this paper proposes a quantitative approach based on a biomathematical model. The model predicts that the net effect of the proliferative-to-invasive transition leads to a lower survival even for slight increments of the invasive capacity of hypoxic tumor cells...
March 1, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
Matthew M Walsh, Glenn Gunzelmann, Hans P A Van Dongen
Computational models have become common tools in psychology. They provide quantitative instantiations of theories that seek to explain the functioning of the human mind. In this paper, we focus on identifying deep theoretical similarities between two very different models. Both models are concerned with how fatigue from sleep loss impacts cognitive processing. The first is based on the diffusion model and posits that fatigue decreases the drift rate of the diffusion process. The second is based on the Adaptive Control of Thought - Rational (ACT-R) cognitive architecture and posits that fatigue decreases the utility of candidate actions leading to microlapses in cognitive processing...
December 2017: Psychonomic Bulletin & Review
Helene von Bibra, Alexander Ströhle, Martin St John Sutton, Nicolai Worm
BACKGROUND: Heart failure is an ongoing epidemic of left ventricular (LV) dilatation and/or dysfunction due to the increasing prevalence of predisposing risk factors such as age, physical inactivity, (abdominal) obesity, and type-2-diabetes. Approximately half of these patients have diastolic heart failure (HFpEF). The prognosis of HFpEF is comparable to that of systolic heart failure, but without any known effective treatment. DIASTOLIC DYSFUNCTION: A biomathematically corrected diagnostic approach is presented that quantifies diastolic dysfunction via the predominant age dependency of LV diastolic function and unmasks (metabolic) risk factors, that are independent of age and, therefore, potential targets for therapy...
May 1, 2017: International Journal of Cardiology
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
Our study aimed to develop a method to mathematically predict the kinetic parameters K1 (influx rate constant), k2 (efflux rate constant), and BPND (nondisplaceable binding potential) of amyloid PET tracers and obtain SUV ratios (SUVRs) from predicted time-activity curves of target and reference regions. Methods: We investigated 10 clinically applied amyloid PET radioligands: (11)C-Pittsburgh compound B, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-florbetapir, (18)F-florbetaben, (18)F-flutemetamol, (18)F-FDDNP, and (18)F-AZD4694...
August 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Clemens Grassberger, Jacob G Scott, Harald Paganetti
No abstract text is available yet for this article.
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Séverine Mollard, Raphaelle Fanciullino, Sarah Giacometti, Cindy Serdjebi, Sebastien Benzekry, Joseph Ciccolini
This study aimed at evaluating the reliability and precision of Diffuse Luminescent Imaging Tomography (DLIT) for monitoring primary tumor and metastatic spreading in breast cancer mice, and to develop a biomathematical model to describe the collected data. Using orthotopic mammary fat pad model of breast cancer (MDAMB231-Luc) in mice, we monitored tumor and metastatic spreading by three-dimensional (3D) bioluminescence and cross-validated it with standard bioluminescence imaging, caliper measurement and necropsy examination...
November 4, 2016: Scientific Reports
Alejandro Garcia-Romero, Araceli Hernandez-Vitoria, Esther Millan-Cebrian, Veronica Alba-Escorihuela, Sonia Serrano-Zabaleta, Pablo Ortega-Pardina
PURPOSE: The aim of this work is to search for new metrics that could give more reliable acceptance/rejection criteria on the IMRT verification process and to offer solutions to the discrepancies found among different conventional metrics. Therefore, besides conventional metrics, new ones are proposed and evaluated with new tools to find correlations among them. These new metrics are based on the processing of the dose-volume histogram information, evaluating the absorbed dose differences, the dose constraint fulfillment, or modified biomathematical treatment outcome models such as tumor control probability (TCP) and normal tissue complication probability (NTCP)...
November 2016: Medical Physics
Yuanyuan Li, David Heckmann, Martin J Lercher, Veronica G Maurino
To feed a world population projected to reach 9 billion people by 2050, the productivity of major crops must be increased by at least 50%. One potential route to boost the productivity of cereals is to equip them genetically with the 'supercharged' C4 type of photosynthesis; however, the necessary genetic modifications are not sufficiently understood for the corresponding genetic engineering programme. In this opinion paper, we discuss a strategy to solve this problem by developing a new paradigm for plant breeding...
January 2017: Journal of Experimental Botany
Helene von Bibra, Walter Paulus, Martin St John Sutton
Approximately 50 % of patients with heart failure have diastolic heart failure (HFPEF) with the major predisposing risk factors age, inactivity, obesity, insulin resistance (IR), type-2 diabetes, and hypertension. The prognosis of HFPEF is comparable to that of systolic heart failure, but without any specific or effective treatment. This review presents a biomathematically corrected diagnostic approach for quantification of diastolic dysfunction (DD) via the age dependency of diastolic function. Pathophysiological mechanisms for DD in the cardiometabolic syndrome (CMS) are mainly based on downstream effects of IR including insufficient myocardial energy supply...
October 2016: Current Heart Failure Reports
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