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https://www.readbyqxmd.com/read/28526159/anticoagulation-and-neuraxial-peripheral-anesthesia
#1
REVIEW
Mudit Kaushal, Ryan E Rubin, Alan D Kaye, Karina Gritsenko
Novel anticoagulants (NAGs) have emerged as the preferred alternatives to vitamin K antagonists. In patients being considered for regional anesthesia, these drugs present a layer of complexity in the preprocedure evaluation. There are no established tests to monitor anticoagulant activity and our experience is short with these drugs. These authors believe it is important to review the relevant hematology, orthopedics, and anesthesiology literature to provide a valuable reference for the clinician who is met with these challenges...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28521011/translation-initiation-events-on-structured-eukaryotic-mrnas-generate-gene-expression-noise
#2
Estelle Dacheux, Naglis Malys, Xiang Meng, Vinoy Ramachandran, Pedro Mendes, John Eg McCarthy
Gene expression stochasticity plays a major role in biology, creating non-genetic cellular individuality and influencing multiple processes, including differentiation and stress responses. We have addressed the lack of knowledge about posttranscriptional contributions to noise by determining cell-to-cell variations in the abundance of mRNA and reporter protein in yeast. Two types of structural element, a stem-loop and a poly(G) motif, not only inhibit translation initiation when inserted into an mRNA 5΄ untranslated region, but also generate noise...
May 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28514167/quantum-dot-peptide-fullerene-bioconjugates-for-visualization-of-in-vitro-and-in-vivo-cellular-membrane-potential
#3
Okhil Kumar Nag, Michael H Stewart, Jeffrey R Deschamps, Kimihiro Susumu, Eunkeu Oh, Vassiliy Tsytsarev, Qinggong Tang, Alexander L Efros, Roman Vaxenburg, Bryan J Black, Yungchia Chen, Thomas J O'Shaughnessy, Stella H North, Lauren D Field, Philip E Dawson, Joseph J Pancrazio, Igor L Medintz, Yu Chen, Reha S Erzurumlu, Alan L Huston, James B Delehanty
We report the development of a quantum dot (QD)-peptide-fullerene (C60) electron transfer (ET)-based nanobioconjugate for the visualization of membrane potential in living cells. The bioconjugate is comprised of (1) a central QD electron donor, (2) a membrane-inserting peptidyl linker, and (3) a C60 electron acceptor. The photoexcited QD donor engages in ET with the C60 acceptor resulting in quenching of QD photoluminescence (PL) that tracks positively with the number of C60 moieties arrayed around the QD. The nature of the QD-capping ligand also modulates the quenching efficiency; a neutral ligand coating facilitates greater QD quenching than a negatively charged carboxylated ligand...
May 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28510740/propofol-based-anaesthesia-versus-sevoflurane-based-anaesthesia-for-living-donor-kidney-transplantation-results-of-the-vapor-1-randomized-controlled-trial
#4
G J Nieuwenhuijs-Moeke, V B Nieuwenhuijs, M A J Seelen, S P Berger, M C van den Heuvel, J G M Burgerhof, P J Ottens, R J Ploeg, H G D Leuvenink, M M R F Struys
Background: Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. We therefore conducted the Volatile Anaesthetic Protection of Renal Transplants-1 trial, a pilot project evaluating the influence of two anaesthetic regimens, propofol- vs sevoflurane-based anaesthesia, on biochemical and clinical outcomes in living donor kidney transplantation...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28506633/-anaerobiospirillum-succiniciproducens-and-desulfovibrio-desulfuricans-in-2-cases-of-insidious-bacteremia
#5
Silvia C Predari, Adriana N de Paulis, Eugenia Bertona, Daiana Guevara Núñez, Juan P Suárez, Liliana Castello
Two cases of insidious bacteremia by uncommon curve and spiral-shaped, motile anaerobic gram-negative rods are presented. Both of them were of an unclear origin and occurred in immunosuppressed patients with simultaneous diseases. The key tests for the identification of Anaerobiospirillum were its micromorphology, a strictly anaerobic condition, negative catalase activity, the special-potency disk profile, glucose fermentation, and β-NAG production. Desulfovibrio species was identified by all the above preliminary tests but with a different disk profile, as well as for being asaccharolytic and desulfoviridin and H2S producer...
May 12, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28504975/ce-original-research-the-experiences-of-pregnant-smokers-and-their-providers
#6
Geraldine Rose Britton, Rosemary Collier, Sean McKitrick, Lori Marie Sprague, Joyce Rhodes-Keefe, Ann Feeney, Gary D James
Study findings suggest ways to better address tobacco use. ABSTRACT: Background: The U.S. Department of Health and Human Services' initiative Healthy People 2020 targets tobacco use, including smoking during pregnancy, as a continuing major health concern in this country. Yet bringing the U.S. Public Health Service's 2008 clinical practice guideline, Treating Tobacco Use and Dependence, into routine prenatal care remains challenging. Our previous nurse-managed intervention study of rural pregnant women found no significant cessation effect and significant discordance between selfreported smoker status and urinary cotinine levels...
May 11, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28497240/in-vivo-anticancer-efficacy-and-toxicity-studies-of-a-novel-polymer-conjugate-n-acetyl-glucosamine-nag-peg-doxorubicin-for-targeted-cancer-therapy
#7
Smita Pawar, Ketan Mahajan, Pradeep Vavia
A novel polymer-drug conjugate, polyethylene glycol-N-(acetyl)-glucosamine-doxorubicin (PEG-NAG-DOX) was evaluated in this study for its in vivo potential for treatment of tumours demonstrating improved efficacy and reduced toxicity. The proposed polymer-drug conjugate comprised of polyethylene glycol-maleimide (mPEG-MAL, 30000 Da) as a carrier, doxorubicin (DOX) as an anticancer drug and N-acetyl glucosamine (NAG) as a targeting moiety as well as penetration enhancer. Doxorubicin has a potent and promising anticancer activity; however, severe cardiotoxicity limits its application in cancer treatment...
May 11, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28496205/characterisation-of-a-3-hydroxypropionic-acid-inducible-system-from-pseudomonas-putida-for-orthogonal-gene-expression-control-in-escherichia-coli-and-cupriavidus-necator
#8
Erik K R Hanko, Nigel P Minton, Naglis Malys
3-hydroxypropionic acid (3-HP) is an important platform chemical used as a precursor for production of added-value compounds such as acrylic acid. Metabolically engineered yeast, Escherichia coli, cyanobacteria and other microorganisms have been developed for the biosynthesis of 3-HP. Attempts to overproduce this compound in recombinant Pseudomonas denitrificans revealed that 3-HP is consumed by this microorganism using the catabolic enzymes encoded by genes hpdH, hbdH and mmsA. 3-HP-inducible systems controlling the expression of these genes have been predicted in proteobacteria and actinobacteria...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493845/histopathological-findings-of-renal-tissue-induced-by-oxidative-stress-due-to-different-concentrations-of-fluoride
#9
Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
It has been reported that excessive intake of fluoride can induce renal lesions. However, its pathogenesis is still less understood. Therefore, this study was conducted to investigate oxidative damage and the relationships between the oxidative damage and renal lesions in fluoride-treated mice by using the methods of histopathology, biochemistry, flow cytometry and quantitative real-time polymerase chain reaction (qRT-PCR). A total of 240 ICR mice were randomly divided into four equal groups (sodium fluoride was given orally at the dose of 0, 12, 24 and 48 mg/kg body weight for 42 days, respectively)...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493391/haplotype-reference-consortium-panel-practical-implications-of-imputations-with-large-reference-panels
#10
Adriana I Iglesias, Sven J van der Lee, Pieter W M Bonnemaijer, René Höhn, Abhishek Nag, Puya Gharahkhani, Anthony P Khawaja, Linda Broer, Paul J Foster, Christopher J Hammond, Pirro G Hysi, Elisabeth M van Leeuwen, Stuart MacGregor, David A Mackey, Johanna Mazur, Stefan Nickels, André G Uitterlinden, Caroline C W Klaver, Najaf Amin, Cornelia M van Duijn
Recently, the Haplotype Reference Consortium (HRC) released a large imputation panel that allows more accurate imputation of genetic variants. In this study, we compared a set of directly assayed common and rare variants from an exome array to imputed genotypes, i.e., 1000 genomes project (1000GP) and HRC. We showed that imputation using the HRC panel improved the concordance between assayed and imputed genotypes at common, and especially, low-frequency variants. Furthermore, we performed a genome-wide association meta-analysis of vertical cup-disc ratio (VCDR), a highly heritable endophenotype of glaucoma, in four cohorts using 1000GP and HRC imputations...
May 10, 2017: Human Mutation
https://www.readbyqxmd.com/read/28491856/renal-tissue-pro-inflammatory-gene-expression-is-reduced-by-erythropoietin-in-rats-subjected-to-hemorrhagic-shock
#11
Mina Ranjbaran, Mehri Kadkhodaee, Behjat Seifi
BACKGROUND: Hemorrhagic shock (HS) is a condition produced by considerable loss of intravascular volume, which may eventually lead to organ damage and death. OBJECTIVES: In the present study, the potential implication of the kidney tissue tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were evaluated in the protective effects of erythropoietin (EPO) during HS. MATERIALS AND METHODS: Male Wistar rats were randomized into three experimental groups; Sham, HS (hemorrhagic shock and resuscitation), and EPO (erythropoietin)...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28488599/random-reflections
#12
Devika Nag
No abstract text is available yet for this article.
May 2017: Neurology India
https://www.readbyqxmd.com/read/28485059/renal-medullary-carcinoma-a-national-analysis-of-159-patients
#13
Brian Ezekian, Brian Englum, Brian F Gilmore, Uttara P Nag, Jina Kim, Harold J Leraas, Jonathan C Routh, Henry E Rice, Elisabeth T Tracy
BACKGROUND: Renal medullary carcinoma (RMC) is an aggressive malignancy seen predominantly in young males with sickle cell trait. RMC is poorly understood, with fewer than 220 cases described in the medical literature to date. We used a large national registry to define the typical presentation, treatments, and outcomes of this rare tumor. METHODS: The National Cancer Database was queried for patients under 40 years of age diagnosed with RMC from 1998 to 2011. An analysis of patient and tumor characteristics, treatment details, and overall survival (OS) was undertaken, and factors associated with mortality were identified using multivariable regression analysis...
May 9, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28484684/the-nag-sensor-nagc-regulates-lee-gene-expression-and-contributes-to-gut-colonization-by-escherichia-coli-o157-h7
#14
Guillaume Le Bihan, Jean-Félix Sicard, Philippe Garneau, Annick Bernalier-Donadille, Alain P Gobert, Annie Garrivier, Christine Martin, Anthony G Hay, Francis Beaudry, Josée Harel, Grégory Jubelin
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 are human pathogens responsible for bloody diarrhea and renal failures. EHEC employ a type 3 secretion system to attach directly to the human colonic epithelium. This structure is encoded by the locus of enterocyte effacement (LEE) whose expression is regulated in response to specific nutrients. In this study, we show that the mucin-derived sugars N-acetylglucosamine (NAG) and N-acetylneuraminic acid (NANA) inhibit EHEC adhesion to epithelial cells through down-regulation of LEE expression...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28484209/synergic-bactericidal-effects-of-reduced-graphene-oxide-and-silver-nanoparticles-against-gram-positive-and-gram-negative-bacteria
#15
Karthika Prasad, G S Lekshmi, Kola Ostrikov, Vanessa Lussini, James Blinco, Mandhakini Mohandas, Krasimir Vasilev, Steven Bottle, Kateryna Bazaka, Kostya Ostrikov
Reduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nAg). In this study, the mechanisms of antibacterial activity of rGO-nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli and Proteus mirabilis are investigated. At the same concentration (100 µg/ml), rGO-nAg nanocomposite was significantly more effective against all three pathogens than either rGO or nAg...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481356/the-myosin-mesa-and-the-basis-of-hypercontractility-caused-by-hypertrophic-cardiomyopathy-mutations
#16
Suman Nag, Darshan V Trivedi, Saswata S Sarkar, Arjun S Adhikari, Margaret S Sunitha, Shirley Sutton, Kathleen M Ruppel, James A Spudich
Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin measured so far do not explain the clinical hypercontractility caused by such mutations. We propose that hypercontractility is due to an increase in the number of myosin heads (S1) that are accessible for force production. In support of this hypothesis, we demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human β-cardiac myosin ATPase...
May 8, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28472368/the-2-%C3%AE-m-plasmid-encoded-protein-raf1-regulates-both-stability-and-copy-number-of-the-plasmid-by-blocking-the-formation-of-the-rep1-rep2-repressor-complex
#17
Syed M A Rizvi, Hemant K Prajapati, Purba Nag, Santanu K Ghosh
The 2-μm plasmid of the budding yeast Saccharomyces cerevisiae achieves a high chromosome-like stability with the help of four plasmid-encoded (Rep1, Rep2, Raf1 and Flp) and several host-encoded proteins. Rep1 and Rep2 and the DNA locus STB form the partitioning system ensuring equal segregation of the plasmid. The Flp recombinase and its target sites FRTs form the amplification system which is responsible for the steady state plasmid copy number. In this work we show that the absence of Raf1 can affect both the plasmid stability and the steady sate copy number...
May 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28463254/stimulated-emission-in-aluminum-laser-induced-plasma-an-experimental-study
#18
Reto Glaus, Igor Gornushkin, Lev Nagli
The stimulated emission (SE) in aluminum laser-induced plasma pumped in resonance with the 3s<sup>2</sup>3p-3s<sup>2</sup>4s aluminum transition at 266.04 nm is investigated experimentally. It is shown that the population inversion between the 3s<sup>2</sup>3p and 3s<sup>2</sup>4s states can be created by weak pumping at several microjoule to millijoule pulse energies and result in high gain. The intensity of the SE at 396.15 nm is related to the number density of Al atoms via absorption measurements...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28455268/nsaid-activated-gene-1-and-its-implications-for-mucosal-integrity-and-intervention-beyond-nsaids
#19
REVIEW
Yuseok Moon
In spite of the beneficial actions of non-steroid anti-inflammatory drugs (NSAIDs) in epithelial inflammation and cancers, their use is limited because of their cyclooxygenase-dependent or independent gastrointestinal toxicity. As an eicosanoid-independent mediator, NSAID-activated gene 1 (NAG-1) has been assessed for its involvement in cellular integrity and pathogenesis in mucosal inflammation and carcinogenesis. At the cellular levels, NAG-1 is involved in the cell growth regulation (cell death, cell cycle arrest, or proliferation) in epithelial and mesenchymal tissues...
April 25, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28446439/pax3-foxo1-establishes-myogenic-super-enhancers-and-confers-bet-bromodomain-vulnerability
#20
Berkley E Gryder, Marielle E Yohe, Hsien-Chao Chou, Xiaohu Zhang, Joana Marques, Marco Wachtel, Beat Schaefer, Nirmalya Sen, Young K Song, Alberto Gualtieri, Silvia Pomella, Rossella Rota, Abigail Cleveland, Xinyu Wen, Sivasish Sindiri, Jun S Wei, Frederic G Barr, Sudipto Das, Thorkell Andresson, Rajarshi Guha, Madhu Lal-Nag, Marc Ferrer, Jack F Shern, Keji Zhao, Craig J Thomas, Javed Khan
Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent young adults, driven primarily by the chimeric transcription factor PAX3-FOXO1 (P3F). The mechanisms by which P3F dysregulates chromatin are unknown. We find P3F reprograms the cis-regulatory landscape by inducing (de novo) super enhancers (SEs). P3F uses SEs to setup auto-regulatory loops in collaboration with master transcription factors MYOG, MYOD and MYCN. This myogenic SE circuitry is consistent across cell lines and primary tumors...
April 26, 2017: Cancer Discovery
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