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Kishore P Madhwani, P K Nag
Background: Use of laptops and hand-held devices increase the risk of musculoskeletal disorders (MSDs). More time spent on this activity adopting faulty postures, higher the risk of developing such injuries. This study addresses training on office ergonomics with emphasis on sustainable behavior change among employees to work in safe postures, as this is a top priority in the corporate environment, today. Aim: To explore training intervention methods that ensure wider coverage of awareness on office ergonomics, thereby promoting safer working and suggesting sustainable programs for behavior change and job enrichment...
May 2017: Indian Journal of Occupational and Environmental Medicine
Soisungwan Satarug
Cadmium (Cd) is a food-chain contaminant that has high rates of soil-to-plant transference. This phenomenon makes dietary Cd intake unavoidable. Although long-term Cd intake impacts many organ systems, the kidney has long been considered to be a critical target of its toxicity. This review addresses how measurements of Cd intake levels and its effects on kidneys have traditionally been made. These measurements underpin the derivation of our current toxicity threshold limit and tolerable intake levels for Cd...
March 10, 2018: Toxics
Suelen S da Silva, Sandra S Mizokami, Jacqueline R Fanti, Idessania N Costa, Juliano Bordignon, Ionice Felipe, Wander R Pavanelli, Waldiceu A Verri, Ivete Conchon Costa
OBJECTIVES: To evaluate the analgesic effect of Glucantime (antimoniate N-methylglucamine) in Leishmania amazonensis infection and complete Freund's adjuvant (CFA), chronic paw inflammation model, in BALB/c mice. METHODS: Two models of chronic inflammatory pain in BALB/c mice paw were used: infection with L. amazonensis and CFA stimulation. Both animals models received daily treatment with Glucantime (10 mg/kg, i.p.) and during the treatment was measured the mechanical hyperalgesia with electronic version of von Frey filaments...
March 12, 2018: Journal of Pharmacy and Pharmacology
Lata Singh, Neeru Saini, Neelam Pushker, Sameer Bakhshi, Seema Sen, Tapas C Nag, Seema Kashyap
Alteration in mitochondrial DNA plays an important role in the development and progression of cancer. The Displacement Loop (D-loop) region of mitochondrial DNA (mtDNA) is the regulatory region for its replication and transcription. Therefore, we aimed to characterize mutations in the D-loop region of mitochondrial DNA along with the morphological changes and analyzed their impact on survival in retinoblastoma patients. mtDNA D-loop region was amplified by Nested-Polymerase Chain Reaction (Nested-PCR) and mutations were analyzed in 60 tumor samples from retinoblastoma patients by DNA sequencing...
March 12, 2018: Pathology Oncology Research: POR
Yue Yang, Long Chen, Yuan Jia, Yang Liu, Lei Wen, Yaoxian Liang, Yuan An, Shi Chen, Yin Su, Zhanguo Li
To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Screening for the presence of MG was performed in 872 inpatients with rheumatic diseases from January 2010 to July 2017. A total of 41 patients were enrolled. Their clinical and biological features in addition to outcomes were described. For each patient with primary Sjögren syndrome (pSS), 2 age- and sex-matched pSS patients without MG were selected as controls. Risk factors for the presence of MG and malignant hematological neoplasias were assessed...
March 13, 2018: Clinical Rheumatology
Warren Pan, Jessica M Adams, Margaret B Allison, Christa Patterson, Jonathan N Flak, Justin Jones, Garth Strohbehn, James Trevaskis, Christopher J Rhodes, David P Olson, Martin G Myers
The adipocyte-derived hormone, leptin, acts via its receptor (LepRb) on central nervous system neurons to communicate the repletion of long-term energy stores, to decrease food intake and promote energy expenditure. We generated mice that express cre recombinase from the calcitonin receptor (Calcr) locus (Calcrcre mice) to study Calcr-expressing LepRb (LepRbCalcr) neurons, which reside predominantly in the arcuate nucleus (ARC). Calcrcre-mediated ablation of LepRb in LepRbCalcrKO mice caused hyperphagic obesity...
March 7, 2018: Endocrinology
Diana Hilda Hohl, Janina Lüscher, Jan Keller, Silke Heuse, Urte Scholz, Aleksandra Luszczynska, Nina Knoll
OBJECTIVES: In romantic relationships, partners can influence each other's health-relevant behaviour by exerting negative social control (e.g., pressuring), however, with mixed success. To elucidate this phenomenon, we examined couples motivated to increase their physical activity and investigated the degree to which both partners exerted negative control on each other, their self-efficacy, reciprocal associations among the two behaviour-specific constructs, and their relationship with moderate-to-vigorous physical activity (MVPA)...
March 8, 2018: British Journal of Health Psychology
Huiting Liu, Xueyuan Gu, Chenhui Wei, Heyun Fu, Pedro J J Alvarez, Qilin Li, Shourong Zheng, Xiaolei Qu, Dongqiang Zhu
Sunlight-induced photo-formation of silver nanoparticles (nAg), mediated by natural organic matter (NOM), is significantly affected by the concentration of Ag(I) and chloride. The initial photo-formation rates of nAg in Suwannee River humic acid (SRHA) and Suwannee River natural organic matter (SRNOM) solutions were examined under simulated sunlight irradiation. A critical induction concentration (CIC) of Ag(I) (10 mg/L for SRHA and 5 mg/L for SRNOM, respectively) was observed below which the nAg formation was minimal...
March 5, 2018: Environmental Science & Technology
Tuan-Mao Guo, Yong Yan, Wei-Ning Cao, Qiang Liu, Hai-Yun Zhu, Lan Yang, Mai-Cang Gao, Yan-Li Xing
Ankylosing spondylitis (AS) is a common chronic rheumatic disorder, accompanied by the differential expression of various microRNAs (miRNAs) in patients suffering from the condition, some of which have the potential to serve as novel complementary AS biomarkers. During this study, AS patients were recruited in connection with our investigation into the correlation of microRNA-132 (miR-132) in peripheral blood and its target gene NAG-1 expressions in relation with the clinical efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) treatment in patients with AS...
March 1, 2018: Clinical Rheumatology
Reetoja Nag, Raunak Kumar Das
This paper provides a review of various image analysis approaches that have been previously used for recognition of dysplasia in images of the epithelium of the oral cavity. This domain has become especially admissible with the uncovering of the importance of image analysis which can probably be an aid to subjective diagnosis by histopathologists. Oral malignancy is a rampant form of cancer found among people of the Indian subcontinent due to various deleterious habits like consumption of tobacco, areca nut, betel leaf etc...
March 2018: Oral Oncology
Dipayan Chakraborty, Pamir Nag, Dhananjay Nandi
A new time of flight mass spectrometer (TOFMS) has been developed to study the absolute dissociative electron attachment (DEA) cross section using a relative flow technique of a wide variety of molecules in gas phase, ranging from simple diatomic to complex biomolecules. Unlike the Wiley-McLaren type TOFMS, here the total ion collection condition has been achieved without compromising the mass resolution by introducing a field free drift region after the lensing arrangement. The field free interaction region is provided for low energy electron molecule collision studies...
February 2018: Review of Scientific Instruments
Papri Chakraborty, Ananya Baksi, Sathish Kumar Mudedla, Abhijit Nag, Ganesan Paramasivam, Venkatesan Subramanian, Thalappil Pradeep
Proton transfer reactions have been a topic of fundamental interest in several areas of chemistry and biology. However, such reactivity has not been explored in detail for nanoscale materials. In this article, we present a unique reaction of an atomically precise monolayer-protected silver nanocluster, [Ag29 (BDT)12 ]3- , with a proton (H+ ). Under controlled conditions, the strong proton affinity facilitated a complete conversion of the cluster to its protonated form, [Ag29 (BDT)12 H]2- . Moreover, binding of alkali metal ions (Li+ , Na+ , K+ , Rb+ and Cs+ ) induced specific structural changes and also favored dimerization of the cluster...
March 1, 2018: Physical Chemistry Chemical Physics: PCCP
Xuejun Zhang, Hongyan Zhou, Yan Li
Objective: To analyze the values of combined detection of urinary micro albumin (mAlb), α1-microglobulin (α1-MG) and N-acetyl-β-D-glucosaminidase (NAG) in the early diagnosis of diabetic nephropathy (DN). Methods: Ninety-four patients with early DN who were admitted to the hospital between April 2015 and April 2016 were selected and set as a DN group. Moreover, seventy-six patients with diabetes who were admitted to the hospital in the same period were selected and set as a diabetes group, and sixty-four healthy people were selected as set as a control group...
November 2017: Pakistan Journal of Medical Sciences Quarterly
Sarita Saraswati, Abdulqader A Alhaider, Abdelgalil M Abdelgadir
Costunolide is known to possess anti-inflammatory and antitumor activity, but its role in tumor angiogenesis, the key step involved in tumor growth and metastasis, and the involved molecular mechanism is still unknown. We aimed to investigate the effects of costunolide on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and costunolide (5, 10 and 20 mg/kg/day) was administered for 14 days through installed cannula...
March 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Nicola Zerbinati, Torello Lotti, Damiano Monticelli, Virginia Martina, Giovanna Cipolla, Edoardo D'Este, Alberto Calligaro, Roberto Mocchi, Cristina Maccario, Sabrina Sommatis, Jacopo Lotti, Uwe Wollina, Georgi Tchernev, Katlein França
Neauvia Intense is biocompatible, injectable hyaluronic acid (HA) filler PEG cross-linked for facial soft-tissue augmentation that provides volume to tissues. The aim of the present study is to evaluate the sensitivity of Neauvia Intense in hyaluronidase from bovine testes in a time-course analysis. The test is based on the colourimetric determination of the N-acetyl - D - glucosamine (NAG) released by the hyaluronidase in standardised conditions. The in vitro conditions involve the treatment of Neauvia Intense with a known concentration of the enzyme (6080U/ml)...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Sidsel Nag, Poul-Erik Kofoed, Johan Ursing, Camilla Koldbæk Lemvigh, Rosa Lundbye Allesøe, Amabelia Rodrigues, Christina Aaby Svendsen, Jacob Dyring Jensen, Michael Alifrangis, Ole Lund, Frank M Aarestrup
BACKGROUND: Plasmodium falciparum malaria remains a major health burden and genomic research represents one of the necessary approaches for continued progress towards malaria control and elimination. Sample acquisition for this purpose is troublesome, with the majority of malaria-infected individuals living in rural areas, away from main infrastructure and the electrical grid. The aim of this study was to describe a low-tech procedure to sample P. falciparum specimens for direct whole genome sequencing (WGS), without use of electricity and cold-chain...
February 23, 2018: Malaria Journal
John B Schrock, Trevor J Carver, Matthew J Kraeutler, Eric C McCarty
BACKGROUND: Previous studies have analyzed the treatment patterns used to manage injuries in National Football League (NFL) players. HYPOTHESIS: Treatment patterns for injuries in NFL players will have changed over the study period. STUDY DESIGN: Descriptive epidemiology study. LEVEL OF EVIDENCE: Level 5. METHODS: The head orthopaedic team physicians for all 32 NFL teams were asked to complete a survey containing questions regarding experience as team physician, medical coverage of the team, and treatment preferences for some of the most common injuries occurring in football players...
February 1, 2018: Sports Health
M-H Zhang, L-P Zhai, Z-Y Fang, A-N Li, Y Qiu, Y-X Liu
The aim of this study was to observe sperm aneuploidy, DNA integrity, seminal alpha-glucosidase (NAG) and acrosin activity (AA) under testicular heat stress (SH). Spermatozoa were obtained from 30 healthy adult volunteers subjected to scrotal warming at 43°C for 30-40 min on two successive days per week for 3 months between February 2012 and September 2016. Aniline blue (AB), acridine orange (AO) staining, TUNEL assay and FISH analysis to evaluate sperm function, sperm DNA integrity and chromosomal abnormalities were carried on before, during and after SH...
February 22, 2018: Andrologia
Richard H Stanford, Arpita Nag, Douglas W Mapel, Todd A Lee, Richard Rosiello, Michael Schatz, Francis Vekeman, Marjolaine Gauthier-Loiselle, J F Philip Merrigan, Mei Sheng Duh
OBJECTIVES: To develop and validate a predictive model for first severe chronic obstructive pulmonary disease (COPD) exacerbation using health insurance claims data and to validate the risk measure of controller medication to total COPD treatment (controller and rescue) ratio (CTR). STUDY DESIGN: A predictive model was developed and validated in 2 managed care databases: Truven Health MarketScan database and Reliant Medical Group database. This secondary analysis assessed risk factors, including CTR, during the baseline period (Year 1) to predict risk of severe exacerbation in the at-risk period (Year 2)...
February 1, 2018: American Journal of Managed Care
Karlina J Kauffman, Shenliang Yu, Jiaxin Jin, Brian Mugo, Nathan Nguyen, Aidan O'Brien, Shanta Nag, Alf Håkon Lystad, Thomas J Melia
During macroautophagy/autophagy, mammalian Atg8-family proteins undergo 2 proteolytic processing events. The first exposes a COOH-terminal glycine used in the conjugation of these proteins to lipids on the phagophore, the precursor to the autophagosome, whereas the second releases the lipid. The ATG4 family of proteases drives both cleavages, but how ATG4 proteins distinguish between soluble and lipid-anchored Atg8 proteins is not well understood. In a fully reconstituted delipidation assay, we establish that the physical anchoring of mammalian Atg8-family proteins in the membrane dramatically shifts the way ATG4 proteases recognize these substrates...
February 20, 2018: Autophagy
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