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https://www.readbyqxmd.com/read/28728545/the-potential-value-of-serum-pepsinogen-for-the-diagnosis-of-atrophic-gastritis-among-the-health-check-up-populations-in-china-a-diagnostic-clinical-research
#1
Yuling Tong, Yulian Wu, Zhenya Song, Yingying Yu, Xinyan Yu
BACKGROUND: The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up populations in China. METHODS: Patients from consecutive regular health check-up were enrolled from January 2014 to June 2015. Endoscopy, combined with monitoring the Helicobacter pylori (Hp) infections, and measuring the serum pepsinogen (PG) were used to determine the diagnostic accuracy of PG for the screening of atrophic gastritis...
July 20, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28727722/an-attenuated-shigella-mutant-lacking-the-rna-binding-protein-hfq-provides-cross-protection-against-shigella-strains-of-broad-serotype
#2
Jiro Mitobe, Ritam Sinha, Soma Mitra, Dhrubajyoti Nag, Noriko Saito, Ken Shimuta, Nobuo Koizumi, Hemanta Koley
Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain. Here, immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection by S. dysenteriae type 1 and S. sonnei strains. This deletion mutant lacked the RNA-binding protein Hfq leading to increased expression of the type III secretion system via loss of regulation, resulting in attenuation of cell viability through repression of stress response sigma factors...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28710696/mesocotyl-elongation-is-essential-for-seedling-emergence-under-deep-seeding-condition-in-rice
#3
Hyun-Sook Lee, Kazuhiro Sasaki, Ju-Won Kang, Tadashi Sato, Won-Yong Song, Sang-Nag Ahn
BACKGROUND: Direct-seeding cultivation by deep-seeding of seeds (drill seeding) is becoming popular due to the scarcity of land and labor. However, poor emergence and inadequate seedling establishment can lead to yield loss in direct-seeding cultivation by deep-sowing. In rice, mesocotyl and coleoptile are primarily responsible for seedling emergence from deeper levels of soil. RESULTS: Quantitative trait loci (QTLs) for mesocotyl and coleoptile length at 5-cm seeding depth were detected using 98 backcross inbred lines from a cross between Kasalath and Nipponbare...
December 2017: Rice
https://www.readbyqxmd.com/read/28707603/ginseng-for-the-treatment-of-hypertension-a-systematic-review-and-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#4
Hye Won Lee, Hyun- Ja Lim, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
BACKGROUND: Evidence of ginseng for reducing blood pressure (BP) in hypertensive patients is controversial. This systematic review updated the previous reviews and evidence for it. METHODS: Ten databases were searched from their inception through October 2016, without language restriction. Randomized clinical trials (RCTs) were included if any types of ginseng were tested as the sole treatment or as an adjunct to other treatments for pre-hypertension or hypertension...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28706744/management-of-oromandibular-dystonia-a-case-report-and-literature-update
#5
Suma Gn, Adrita Nag
Oromandibular dystonia (OMD) is a movement disorder characterized by involuntary, paroxysmal, and patterned muscle contractions of varying severity resulting in sustained spasms of masticatory muscles, affecting the jaws, tongue, face, and pharynx. It is most commonly idiopathic or medication-induced, but peripheral trauma sometimes precedes the condition. We present a case report of a 26-year-old female patient who suffered repetitive bouts of hemifacial muscle contractions for 2 years on closing the mouth which interfered in patient's well-being and quality of life by hampering her ability to eat and talk and to the extent of inability to breath due to contractions of her neck muscles...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28698140/n-arachidonoyl-glycine-another-endogenous-agonist-of-gpr55
#6
Linda Console-Bram, Sandra M Ciuciu, Pingwei Zhao, Robert E Zipkin, Eugen Brailoiu, Mary E Abood
Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-arachidonoyl glycine (NAGly) on a candidate endocannabinoid receptor, GPR55. Our novel findings reveal that NAGly induces concentration dependent increases in calcium mobilization and mitogen-activated protein kinase activities in HAGPR55/CHO cells...
July 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28697922/gl-v9-induced-upregulation-and-mitochondrial-localization-of-nag-1-associates-with-ros-generation-and-cell-death-in-hepatocellular-carcinoma-cells
#7
Xiaobo Zhang, Yue Kang, Tongxin Huo, Ran Tao, Xiaoping Wang, Zhiyu Li, Qinglong Guo, Li Zhao
We have previously reported that a newly synthesized compound, GL-V9 could induce mitochondria-mediated apoptosis in HepG2 cells. However, the underlying mechanisms have not been fully understood yet. In current study, we further showed that GL-V9 exhibited significant inhibitory effect on growth of several hepatocellular carcinoma cell lines. Moreover, GL-V9-induced growth inhibition was coincident with the strong upregulation of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), a TGFβ superfamily member, which has been linked with tumor suppression...
July 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28692093/chemoselective-ligation-reaction-of-n-acetylglucosamine-nag-with-hydrazide-functional-probes-to-determine-galactosyltransferase-activity-by-maldi-mass-spectrometry
#8
Hyojik Yang, Quan Cheng
Quantification of β-1,4-galactosyltransferase (β-1,4-GT) activity is of considerable significance in the diagnosis of various cancers including lung and ovarian cancer. We report here the use of synthetic β-N-acetylglucosamine (NAG) ligands that contain hydrazide functional groups to determine galactosyltransferase activity by mass spectrometry. With hydrazide-linked β-d-NAG as the acceptor, the activity of β-1,4-GT is quantified by matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF) mass spectrometry (MS) with high efficiency...
July 10, 2017: Analyst
https://www.readbyqxmd.com/read/28689525/the-use-of-recombinant-nag-protein-in-spinal-cord-crush-injury-in-a-rat-model
#9
Mohammad M Al-Qattan, Amro Al-Habib, Feras Alshomer, Reginald Bagayawa, Durria Ahmed, Ghada Al-Nafisah, Muhammed Al-Motairi, Hisham Alkhaildi, Medhat K Shier
OBJECTIVE: To evaluate the therapeutic properties of nAG protein during the recovery following acute spinal cord injuries in the rat. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: King Saud University, Riyadh, Saudi Arabia, from September 2014 to September 2015. METHODOLOGY: Eight rats were studied (4 control rats and 4 experimental rats; and hence 50% were controls and 50% were experimental). All rats were subjected to an acute spinal cord injury using the aneurysmal clip injury model...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28689437/the-effect-of-antiepileptic-drugs-on-the-kidney-function-and-structure
#10
S Hamed
Abtract Introduction: Long-term use of antiepileptic drugs (AEDs) is associated with number of somatic conditions. Data from experimental, cross-sectional and prospective studies have evidence for the deleterious effect of some AEDs on the kidney. Areas Covered: This review summarized the current knowledge of the effect of AEDs on the kidney including evidence and mechanisms. Fanconi syndrome was reported with valproate (VPA) therapy in severely disabled children with epilepsy. Renal tubular acidosis and urolithiasis were reported with acetazolamide, topirmate and zonisamide, drugs with carbonic anhydrase inhibition properties...
July 10, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28680209/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan-finding-of-portal-venous-tumor-thrombus-in-a-case-of-primary-gastric-malignancy
#11
Jayanta Das, Soumendranath Ray, Sudipta Nag, Ashish Kumar, Sumit Mukhopadhyay
Intraluminal portal venous tumor thrombus is an infrequent association with primary gastric malignancy. Ultrasonography features such as low pulsatile flow within the thrombus, expansion of vein, and enhancement of thrombus are nonspecific findings for diagnosis. (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan can differentiate between the benign and malignant thrombus as well as it helps proper metastatic work up. We report such a case.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28671682/a-small-molecule-allosteric-inhibitor-of-mycobacterium-tuberculosis-tryptophan-synthase
#12
Samantha Wellington, Partha P Nag, Karolina Michalska, Stephen E Johnston, Robert P Jedrzejczak, Virendar K Kaushik, Anne E Clatworthy, Noman Siddiqi, Patrick McCarren, Besnik Bajrami, Natalia I Maltseva, Senya Combs, Stewart L Fisher, Andrzej Joachimiak, Stuart L Schreiber, Deborah T Hung
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs. Targeting metabolic enzymes has been the focus of recent interest, but effective inhibitors have been difficult to identify. We describe a synthetic azetidine derivative, BRD4592, that kills Mycobacterium tuberculosis (Mtb) through allosteric inhibition of tryptophan synthase (TrpAB), a previously untargeted, highly allosterically regulated enzyme...
July 3, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28670881/ameliorative-effect-of-coenzyme-q10-and-or-candesartan-on-carboplatin-induced-nephrotoxicity-roles-of-apoptosis-transforming-growth-factor-%C3%AE-1-nuclear-factor-kappa-b-and-the-nrf2-ho-1-pathway
#13
Ahmed M Kabel, Abeer A Elkhoely
Background: Carboplatin is a drug that is used for treatment of many types of cancer. However, it may produce serious nephrotoxicity. Candesartan is angiotensin II receptor antagonist employed mainly for control of hypertension. Coenzyme Q10 (CoQ10) is a fat-soluble substance which was proven to have potent antioxidant and anti-inflammatory properties. Aim: Our aim was to study the effects of candesartan and/or CoQ10 on carboplatin-induced nephrotoxicity in mice. Methods: Sixty mice were divided into 6 equal groups: Control untreated; carboplatin; carboplatin + candesartan; carboplatin + CoQ10; carboplatin + carboxymethyl cellulose; and carboplatin + candesartan + CoQ10 group...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28663609/efficacy-of-dexmedetomidine-infusion-for-procedural-comfort-and-intraoperative-sedation-in-patients-undergoing-surgeries-with-subarachnoid-block-a-randomized-double-blind-clinical-trial
#14
Dewan Roshan Singh, Kusha Nag, Amrutha Bindu Nagella, V R Hemanth Kumar, Antony John Charles
INTRODUCTION: There is increasing evidence to include sedation as an integral part of regional anesthesia to ensure patient comfort. This may compromise patient cooperation, an important component of regional anesthesia. We decided to determine the efficacy of dexmedetomidine (0.3 μg/kg/h and 0.5 μg/kg/h) for allaying procedural discomfort and ensuring their cooperation in patients undergoing surgery with subarachnoid block. SETTING: Tertiary care center. MATERIALS AND METHODS: Sixty patients with the American Society of Anesthesiologists physical status Class I and II posted for surgeries under subarachnoid block were randomized into two groups of 30 each to receive dexmedetomidine in a loading dose of 1 μg/kg in both groups followed by continuous infusion of 0...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28662025/biomolecular-changes-that-occur-in-the-antennal-gland-of-the-giant-freshwater-prawn-machrobrachium-rosenbergii
#15
Utpal Bose, Thanapong Kruangkum, Tianfang Wang, Min Zhao, Tomer Ventura, Shahida Akter Mitu, Mark P Hodson, Paul N Shaw, Prasert Sobhon, Scott F Cummins
In decapod crustaceans, the antennal gland (AnG) is a major primary source of externally secreted biomolecules, and some may act as pheromones that play a major role in aquatic animal communication. In aquatic crustaceans, sex pheromones regulate reproductive behaviours, yet they remain largely unidentified besides the N-acetylglucosamine-1,5-lactone (NAGL) that stimulates male to female attraction. In this study, we used an AnG transcriptome of the female giant freshwater prawn (Macrobrachium rosenbergii) to predict the secretion of 226 proteins, including the most abundantly expressed transcripts encoding the Spaetzle protein, a serine protease inhibitor, and an arthropodial cuticle protein AMP 8...
2017: PloS One
https://www.readbyqxmd.com/read/28654982/genetic-african-ancestry-is-associated-with-central-corneal-thickness-and-intraocular-pressure-in-primary-open-angle-glaucoma
#16
Pieter W M Bonnemaijer, Colin Cook, Abhishek Nag, Christopher J Hammond, Cornelia M van Duijn, Hans G Lemij, Caroline C W Klaver, Alberta A H J Thiadens
Purpose: To unravel the relationship between African ancestry, central corneal thickness (CCT), and intraocular pressure (IOP) by estimating the genetic African ancestry (GAA) proportion in primary open-angle glaucoma (POAG) patients and controls from an admixed South African Colored (SAC) and a South African Black (SAB) population. Methods: In this case-control study, 268 POAG patients and 137 controls were recruited from a university clinic in Cape Town, South Africa...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28653226/urinary-biomarkers-in-the-early-detection-and-follow-up-of-tubular-injury-in-childhood-urolithiasis
#17
Mehmet Taşdemir, Dilara Fuçucuoğlu, Suat Hayri Küçük, Meltem Erol, Özgül Yiğit, Ilmay Bilge
BACKGROUND: To investigate relationships among urinary biomarkers [kidney injury molecule-1 (KIM-1), N-acetyl-β-glucosaminidase (NAG)], neutrophil gelatinase-associated lipocalin (NGAL) levels and renal tubular injury in childhood urolithiasis. METHODS: Seventy children [36 girls, mean age: 7.3 ± 5.0 years (0.5-18.2)] with urolithiasis/microlithiasis and 42 controls [18 girls, mean age: 8.5 ± 3.8 years (0.9-16.2)] were included in this multicenter, controlled, prospective cohort study...
June 26, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28648968/comparison-of-unbiased-stereological-estimation-of-total-number-of-cresyl-violet-stained-neurons-and-parvalbumin-positive-neurons-in-the-adult-human-spiral-ganglion
#18
C Kaur, I Pal, S Saini, T G Jacob, T C Nag, A Thakar, D N Bhardwaj, T S Roy
Estimation of total number of neurons in the Spiral Ganglion (SG) at various ages and their functional status is important as these neurons are constantly exposed to noise and other environmental factors that may lead to neuronal loss with aging due to excitotoxic damage. Parvalbumin (PV) is a calcium-binding protein (CBP), found in highly metabolically active neurons. It helps in buffering cytosolic calcium, which is essential for neurotransmitter release. The neurons in the adult human SG express PV more strongly than other CBPs like calbindin and calretinin...
June 22, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28644992/surface-coating-modulated-toxic-responses-to-silver-nanoparticles-in-wolffia-globosa
#19
Xiaoyan Zou, Penghui Li, Jie Lou, Hongwu Zhang
With the omnipresence of silver nanoparticles (AgNPs) in our daily consumer products, their release has raised serious concerns. However, the biochemical mechanisms by which plants counteract the toxicity of nanoparticles are largely unknown. This study investigated the exposure of aquatic Wolffia globosa to ATP-nAg (AgNPs coated with adenosine triphosphate), cit-nAg (AgNPs coated with citrate), and Ag(+). Hill reaction activity was basically lost in W. globosa treated with 10mg/L ATP-nAg and Ag(+), while the activity was still maintained at 38...
June 15, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28637787/biophysics-and-biofluiddynamics-of-primary-cilia-evidence-for-and-against-the-flow-sensing-function
#20
Subhra Nag, Andrew Resnick
Primary cilia have been called "the forgotten organelle" for over 20 years. As cilia now have their own Journal and several books devoted to their study, perhaps it's time to reconsider the moniker "forgotten organelle". In fact, during the drafting of this review, 12 relevant publications have been issued- we therefore apologize in advance for any relevant work we inadvertently omitted. What purpose is yet another ciliary review? The primary goal of this review is to specifically examine the evidence for and against the hypothesized flow-sensing function of primary cilia expressed by differentiated epithelia within a kidney tubule, bringing together differing disciplines and their respective conceptual and experimental approaches...
June 21, 2017: American Journal of Physiology. Renal Physiology
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