Lu Sun, Meiting Shi, Jian Wang, Xiaoxue Han, Jiachun Wei, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Ping Zhang, Andong He, Mengyuan Liu, Ruiling Yan, Xuesong Yang, Ruiman Li, Guang Wang
BACKGROUND: Preeclampsia is a significant pregnancy disorder with an unknown cause, mainly attributed to impaired spiral arterial remodeling. METHODS: Using RNA sequencing, we identified key genes in placental tissues from healthy individuals and preeclampsia patients. Placenta and plasma samples from pregnant women were collected to detect the expression of TPBG (trophoblast glycoprotein). Pregnant rats were injected with TPBG-carrying adenovirus to detect preeclamptic features...
May 8, 2024: Hypertension