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vulva intraepithelial neoplasia

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https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#1
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27661656/committee-opinion-no-675-management-of-vulvar-intraepithelial-neoplasia
#2
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27661648/committee-opinion-no-675-summary-management-of-vulvar-intraepithelial-neoplasia
#3
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27113549/squamous-precursor-lesions-of-the-vulva-current-classification-and-diagnostic-challenges
#4
REVIEW
Lien N Hoang, Kay J Park, Robert A Soslow, Rajmohan Murali
Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. In contrast, VIN of differentiated type (dVIN) occurs in post-menopausal women and develops independent of HPV infection...
June 2016: Pathology
https://www.readbyqxmd.com/read/26983442/vulvar-intraepithelial-neoplasia-grade-3-associated-with-beh%C3%A3-et-s-disease
#5
Daphné Germann, Rosa Catarino, Essia Saiji, Thomas Daikeler, Patrick Petignat, Pierre Vassilakos
BACKGROUND: Little information is available regarding the association between vulvar intraepithelial neoplasia grade 3 (VIN3) and Behçet's disease (BD). We report here concomitant VIN3 and genital ulcers in a patient with BD. CASE: A 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. Biopsies revealed a multifocal VIN3 positive for high-risk human papillomavirus (HPV) 33...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/26974999/the-natural-history-of-vulvar-intraepithelial-neoplasia-differentiated-type-evidence-for-progression-and-diagnostic-challenges
#6
Susan M Bigby, Lois J Eva, Kah Leng Fong, Ronald W Jones
Squamous cell carcinoma of the vulva (SCCV) develops through either human Papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% of SCCV arise independently of HPV, commonly in a background of an inflammatory dermatosis, particularly lichen sclerosus. The likely direct precursor to most of these lesions is vulvar intraepithelial neoplasia (VIN), differentiated type (dVIN), although the evidence is largely circumstantial. There are few reports of progression to carcinoma, and the natural history of this pathway is not well understood...
March 11, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26942352/the-2015-international-society-for-the-study-of-vulvovaginal-disease-issvd-terminology-of-vulvar-squamous-intraepithelial-lesions
#7
Jacob Bornstein, Fabrizio Bogliatto, Hope K Haefner, Colleen K Stockdale, Mario Preti, Tanja G Bohl, Jason Reutter
OBJECTIVES: The impact of terminology for vulvar intraepithelial lesions has been significant over the years, because it has affected diagnosis, treatment, and research. The introduction of the Lower Anogenital Squamous Terminology (LAST) in 2012 raised 2 concerns in relation to vulvar lesions: firstly, the absence of reference to "differentiated vulvar intraepithelial neoplasia" (differentiated VIN) could lead to its being overlooked by health care providers, despite its malignant potential...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26332918/application-of-a-thulium-laser-for-treatment-of-cervical-neoplasias-and-condylomas-a-feasibility-study
#8
Melanie Henes, Bernhard Vogt, Felix Neis, Katharina Rall, Tanja Litzenburger, Diethelm Wallwiener, Sara Y Brucker, Ralf Rothmund
OBJECTIVE: Evaluation of safety, feasibility, and possibilities of the thulium laser, Vela(®), with a wavelength of 1.9 μm for laser treatment of the portio, vagina, and/or vulva. BACKGROUND DATA: Laser techniques have been used for many years in the gynecological setting for the treatment of cervical, vaginal, and vulval intraepithelial neoplasias (CIN, VAIN, VIN) and also for the treatment of condylomas. To date, the most commonly used laser for this treatment is the CO2 laser...
September 2015: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/26174756/photodynamic-therapy-for-premalignant-lesions-of-the-vulva-and-vagina-a-long-term-follow-up-study
#9
Min Chul Choi, Mi Sun Kim, Gee Hoon Lee, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee, Yoon Young Hwang, Seung Jo Kim
BACKGROUND AND OBJECTIVE: We aimed to evaluate responses to photodynamic therapy (PDT) and its long-term efficacy in preserving normal anatomy and function in women with premalignant lesions of the lower genital tract. STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients received PDT for vulvar intraepithelial neoplasia (VIN), vaginal intraepithelial neoplasia (VAIN), or vulvar Paget's disease between January 2003 and December 2013. Patients underwent colposcopy and/or vulvoscopy for assessment of lesions...
July 14, 2015: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/26171917/squamous-cell-carcinoma-of-the-vulva-a-subclassification-of-97-cases-by-clinicopathologic-immunohistochemical-and-molecular-features-p16-p53-and-egfr
#10
Fei Dong, Sakiko Kojiro, Darrell R Borger, Whitfield B Growdon, Esther Oliva
Squamous cell carcinomas (SCCs) of the vulva develop through human papilloma virus (HPV)-associated or HPV-independent pathways, but the relationship between pathogenesis, classification, and prognosis of these tumors is controversial. Therefore, we review the morphology, immunophenotype, and select molecular features of a consecutive series of 97 patients with vulvar SCC with a median clinical follow-up of 3.6 years. Tumors were histologically classified as basaloid (13), warty (11), mixed basaloid and warty (1), keratinizing (68), nonkeratinizing (3), and sarcomatoid (1)...
August 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25930015/vulvar-cancer-a-review-for-dermatologists
#11
REVIEW
Anastasiya Atanasova Chokoeva, Georgi Tchernev, Elena Castelli, Elisabetta Orlando, Shyam B Verma, Markus Grebe, Uwe Wollina
Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies.Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2% of all vulvar cancers...
April 2015: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25797230/prevalence-of-anal-human-papillomavirus-infection-and-anal-hpv-related-disorders-in-women-a-systematic-review
#12
REVIEW
Elizabeth A Stier, Meagan C Sebring, Audrey E Mendez, Fatimata S Ba, Debra D Trimble, Elizabeth Y Chiao
The aim of this study was to systematically review the findings of publications addressing the epidemiology of anal human papillomavirus (HPV) infection, anal intraepithelial neoplasia, and anal cancer in women. We conducted a systematic review among publications published from Jan. 1, 1997, to Sept. 30, 2013, to limit to publications from the combined antiretroviral therapy era. Three searches were performed of the National Library of Medicine PubMed database using the following search terms: women and anal HPV, women anal intraepithelial neoplasia, and women and anal cancer...
September 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25697926/colposcopic-acetowhitening-of-vulvar-lesion-a-validity-study
#13
Joseph T Santoso, Wendy Likes
OBJECTIVE: To evaluate the acetowhite changes of the vulva as a predictor for high grade vulvar intraepithelial neoplasia. METHODS: We performed retrospective analysis from 344 patients referred to our gynecology oncology clinic for genital dysplasia. All patients underwent vulvar colposcopy. Vulvar biopsies were performed for acetowhite changes and visible vulvar lesions such as ulceration, hyperpigmentation, and thickening of the vulvar tissue. High grade vulvar dysplasia was defined as vulvar intraepithelial neoplasia 2 or worse...
August 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25664114/viral-dna-load-of-high-risk-human-papilloma-virus-is-closely-associated-with-the-grade-of-cervical-lesions
#14
Guqun Shen, Jingxin Cheng, Yan Wang, Ping Zhou, Guoqing Zhang
This study is to explore the correlation between the viral load of high-risk human papilloma virus (HPV) and the degree of cervical lesions, as well as the follow-up monitoring role of high-risk HPV measurements in the treatment of patients with cervical lesions. Hybrid capture-2 method was used to measure the amount of high-risk HPV load of 361 patients who were enrolled from January 2009 to December 2010 at the Affiliated Tumor Hospital of Xinjiang Medical University, including 76 cases of cervical squamous carcinoma, 119 cases of cervical intraepithelial neoplasia and 166 cases of cervicitis...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25510069/-diagnosis-and-treatment-of-lichen-sclerosus-review
#15
REVIEW
A Ganovska, S Kovachev, A Nikolov
UNLABELLED: Lichen sclerosus (LS) is a chronic skin disease of the vulva which affects mostly women in the postmenopausal period. The disease affects also men and children. Its frequency is from 1/70 up to 1/1000, whereas for women it is 10 times more frequently. The disease has unknown etiology. Due to the high frequency of accompanying, autoimmune diseases, it is presumed that this disease is a result of immunological processes. Some of patients diagnosed with LS have vulvar intraepithelial neoplasia, while 0...
2014: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/25472459/-extramammary-paget%C3%A2-s-disease-of-the-vulva-a-case-report
#16
D Kolářová, A Havránková, P Líbalová, S Frühaufová, Z Vernerová, E Kučera
OBJECTIVE: Analysis of one case of vulvar extramammary Paget´s disease (EMPD) and associated well differentiated endometrial adenocarcinoma.Desing: A case report. METHODS AND RESULTS: On this case report we present current theoretical knowledge about EMPD, difficulty of diagnostics, treatment and dispensarization the patients with this rare intraepithelial non-squamous neoplasia. We report a rare case of a 62 years old female patient with extramammary Paget´s disease of vulva and associated well differentiated endometrial adenocarcinoma...
November 2014: Ceská Gynekologie
https://www.readbyqxmd.com/read/25339491/adjuvant-topical-treatment-with-imiquimod-5-after-excisional-surgery-for-vin-2-3
#17
M Gentile, P Bianchi, F Sesti, F Sopracordevole, A Biamonti, P Scirpa, M Schimberni, G Cozza, R Marziani, G Di Martino, A Catalano, G N Milazzo, M Zinna, D Caserta, A Frega
OBJECTIVE: Vulvar intraepithelial neoplasia (VIN) is a premalignant lesion of the vulva. The incidence of VIN is increasing. The surgery is currently the gold standard therapy for VIN, but Imiquimod could be a completion to surgery. The aim of this study is to compare the overall complete response, the recurrence rate and the risk factors for recurrence among two groups of patients: women with high grade VIN underwent surgery and patients treated with surgery plus Imiquimod. PATIENTS AND METHODS: 80 patients with histologically diagnosed VIN 2/3 were enrolled in this prospective study...
October 2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25336476/clinical-responses-to-focused-ultrasound-applied-to-women-with-vulval-intraepithelial-neoplasia
#18
Ying Jia, Jin Wu, Man Xu, Liangdan Tang, Chengzhi Li, Ming Luo, Meng Lou
OBJECTIVES: Focused ultrasound waves penetrate superficial tissues and are aimed toward the target tissues at specific depths to exert their biological effects. Focused ultrasound has been applied for a number of clinical indications, including vulval dystrophies and low-grade vulval disease. This study aimed to assess the efficacy and safety of focused ultrasound treatment of high-grade vulval intraepithelial neoplasia (VIN). METHODS: Eighteen women with high-grade VIN were recruited and treated with focused ultrasound...
November 2014: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/25304851/activity-safety-and-feasibility-of-cidofovir-and-imiquimod-for-treatment-of-vulval-intraepithelial-neoplasia-rt%C3%A2-vin-a-multicentre-open-label-randomised-phase-2-trial
#19
RANDOMIZED CONTROLLED TRIAL
Amanda Tristram, Christopher N Hurt, Tracie Madden, Ned Powell, Stephen Man, Sam Hibbitts, Peter Dutton, Sadie Jones, Andrew J Nordin, Raj Naik, Alison Fiander, Gareth Griffiths
BACKGROUND: Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, the standard treatment for patients with vulval intraepithelial neoplasia is surgery, but this approach does not guarantee cure and can be disfiguring, causing physical and psychological problems, particularly in women of reproductive age. We aimed to assess the activity, safety, and feasibility of two topical treatments--cidofovir and imiquimod--as an alternative to surgery in female patients with vulval intraepithelial neoplasia...
November 2014: Lancet Oncology
https://www.readbyqxmd.com/read/25220367/expression-of-coinhibitory-receptors-on-t-cells-in-the-microenvironment-of-usual-vulvar-intraepithelial-neoplasia-is-related-to-proinflammatory-effector-t-cells-and-an-increased-recurrence-free-survival
#20
Edith M G van Esch, Mariette I E van Poelgeest, Simone Kouwenberg, E Michelle Osse, J Baptist M Z Trimbos, Gert Jan Fleuren, Ekaterina S Jordanova, Sjoerd H van der Burg
Human papillomavirus-induced usual-type vulvar intraepithelial neoplasia (uVIN) are infiltrated by immune cells but apparently not cleared. A potential explanation for this is an impaired T cell effector function by an immunesuppressive milieu, coinfiltrating regulatory T cells or the expression of coinhibitory molecules. Here, the role of these potential inhibitory mechanisms was evaluated by a detailed immunohistochemical analysis of T cell infiltration in the context of FoxP3, Tbet, indoleamine 2,3-dioxygenase, programmed cell death 1, T cell immunoglobulin mucin 3 (TIM3), natural killer cell lectin-like receptor A (NKG2A) and galectins-1, -3 and -9...
February 15, 2015: International Journal of Cancer. Journal International du Cancer
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