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vulva intraepithelial neoplasia

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https://www.readbyqxmd.com/read/28719486/p16-expression-and-biological-behavior-of-flat-vulvar-low-grade-squamous-intraepithelial-lesions-lsil
#1
Natasha Lewis, Luis Z Blanco, Kruti P Maniar
Flat low-grade squamous intraepithelial lesion (LSIL) of the vulva [vulvar intraepithelial neoplasia (VIN) 1, flat condyloma] is an uncommon entity with poorly understood biological behavior. We aimed to determine the risk of subsequent vulvar high-grade squamous intraepithelial lesion (HSIL) or carcinoma following a diagnosis of vulvar LSIL/VIN 1, as well as the frequency and predictive value of p16 immunohistochemical expression in this setting. Of the 51 included cases, p16 positivity (diffuse block staining) was identified in 2 (4%)...
November 30, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700430/epidermodysplasia-verruciformis-like-hpv-infection-of-the-vulva-in-immunosuppressed-women
#2
Natkrita Pohthipornthawat, Sarah Feldman, Scott R Granter, Alvaro C Laga, Christopher P Crum, Michael Herfs
The vast majority of vulvar human papilloma virus infections are produced by α human papilloma viruses and consist of exophytic or flat warts and classic or "usual" vulvar intraepithelial neoplasia. This report details 2 examples of epidermodysplasia verruciformis-like lesions of the vulva in women who were immunosuppressed. The most consistent morphologic feature was the presence of abnormal mature keratinocytes with large pale open nuclei with small nucleoli and eosinophilic cytoplasm, situated in the upper epithelial layers...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28577297/prevalence-and-type-distribution-of-human-papillomavirus-in-squamous-cell-carcinoma-and-intraepithelial-neoplasia-of-the-vulva
#3
Mette T Faber, Freja L Sand, Vanna Albieri, Bodil Norrild, Susanne K Kjaer, Freija Verdoodt
In this updated systematic review and meta-analysis, we estimate the pooled prevalence of human papillomavirus (HPV) DNA and HPV type distribution in squamous cell carcinoma of the vulva (vulvar cancer) and vulvar intraepithelial neoplasia (VIN). PubMed, Embase and Cochrane Library databases were used to identify studies published between 1990 and 2015 and using a PCR-based or hybrid capture test to evaluate the presence of HPV DNA in vulvar cancer or VIN. Pooled estimates of the HPV prevalence with corresponding 95% confidence intervals (CI) were calculated based on a random effects model...
June 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28541790/long-lasting-increased-risk-of-human-papillomavirus-related-carcinomas-and-premalignancies-after-cervical-intraepithelial-neoplasia-grade-3-a-population-based-cohort-study
#4
Renée M F Ebisch, Dominiek W E Rutten, Joanna IntHout, Willem J G Melchers, Leon F A G Massuger, Johan Bulten, Ruud L M Bekkers, Albert G Siebers
Purpose The aim of this study was to determine the risk of human papillomavirus (HPV)-related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. Methods Women diagnosed with a CIN3 between 1990 and 2010 were identified from the Dutch nationwide registry of histopathology and cytopathology (PALGA) and matched with a control group of women without CIN3...
May 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28529603/risk-factors-for-cervical-intraepithelial-neoplasia-and-cervical-cancer-in-chinese-women-large-study-in-jiexiu-shanxi-province-china
#5
Zhilian Wang, Jintao Wang, Jinrong Fan, Weihong Zhao, Xin Yang, Lingmei Wu, Dongyan Li, Ling Ding, Wei Wang, Junjie Xu, Michelle Stram, Chengquan Zhao, Min Hao
We aimed to investigate the risk factors for cervical intraepithelial neoplasia (CIN) in Jiexiu, Shanxi Province, China. Twenty thousand eligible married women (age: 18-65 years) were administered with a questionnaire on potential risk factors for CIN and underwent liquid based Pap test. All women with abnormal cytological results underwent colposcopy with biopsy. Based on the biopsy pathology results, women were then assigned to either study group (with CIN) or control group (negative for histological results and volunteered to participate in the follow up study)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28528690/clinical-relevance-and-implications-of-hpv-induced-neoplasia-in-different-anatomical-locations
#6
REVIEW
Elena Sophie Prigge, Magnus von Knebel Doeberitz, Miriam Reuschenbach
Human papillomaviruses (HPV) are widespread DNA viruses that can infect epithelial cells of the skin and mucosa. Most HPV infections remain clinically unapparent and clear spontaneously. In few cases, however, HPV infections persist and can cause benign and malignant neoplasms at different anatomic locations. Malignant HPV-induced neoplasms are caused by distinct types of HPV (oncogenic or high-risk (HR) HPV types) and present in the anogenital (anus, penis, uterine cervix, vagina and vulva) and head and neck (particularly oropharynx) region...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28398952/vulvar-and-anal-intraepithelial-neoplasia-terminology-diagnosis-and-ancillary-studies
#7
REVIEW
Eric J Yang, Christina S Kong, Teri A Longacre
Currently, it is recognized that there is an HPV-related and an HPV-independent pathway to developing squamous cell carcinomas (SCC) in the anus and vulva. The majority of precursor lesions and SCC in the anus and vulva are high-risk HPV-associated, with HPV16 the most common type. Given the morphologic overlap and biological equivalence of HPV-related preinvasive squamous lesions of the lower anogenital tract, a unified, 2-tiered histopathologic nomenclature is now recommended. In contrast, mutations in the TP53 gene have been associated with HPV-independent vulvar and anal SCC...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28349118/vulvar-condylomatosis-after-sex-reassignment-surgery-in-a-male-to-female-transsexual-complete-response-to-imiquimod-cream
#8
Trinidad Labanca, Ivan Mañero
BACKGROUND: The number of patients seeking sex reassignment surgery is increasing. Approximately 1:30,000 adult males and 1: 100,000 adult females seek this procedure. Neovaginal-related disorders after sex reassignment surgery are increasingly more common. Vulvar condylomatosis is the clinical manifestation of HPV 6- and 11 infection in biological women. The same HPV-subtypes are associated with anogenital warts and penile intraepithelial neoplasia in biological men. We aim to present a case of vulvar condylomatosis after sex reassignment surgery in a male-to-female transsexual and its complete response to 5% imiquimod cream...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28293790/deconstructing-the-genitourinary-syndrome-of-menopause
#9
Pedro Vieira-Baptista, Claudia Marchitelli, Hope K Haefner, Gilbert Donders, Faustino Pérez-López
The concept of genitourinary syndrome of menopause (GSM) was recently introduced and has been gaining widespread use. While some justifications for its introduction are straightforward, others may be questionable. Numerous unspecific symptoms and signs were included in the definition of the syndrome, but the minimum number required for diagnosis was not established. While the GSM definition is designed to facilitate identifying vulvovaginal and urinary estrogen-deprivation-associated symptoms and signs, several concerns have evolved: (1) the syndrome may result in the underdiagnosis of vulvar and urinary pathology; and (2) serious conditions (e...
May 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/27998445/-progression-of-vulva-intraepithelial-neoplasia-grade-%C3%A2-to-vulva-cancer-a-case-report
#10
W H Zhang, P Bai, S M Li, H Sun
No abstract text is available yet for this article.
November 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#11
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
July 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27661656/committee-opinion-no-675-management-of-vulvar-intraepithelial-neoplasia
#12
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27661648/committee-opinion-no-675-summary-management-of-vulvar-intraepithelial-neoplasia
#13
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27113549/squamous-precursor-lesions-of-the-vulva-current-classification-and-diagnostic-challenges
#14
REVIEW
Lien N Hoang, Kay J Park, Robert A Soslow, Rajmohan Murali
Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. In contrast, VIN of differentiated type (dVIN) occurs in post-menopausal women and develops independent of HPV infection...
June 2016: Pathology
https://www.readbyqxmd.com/read/26983442/vulvar-intraepithelial-neoplasia-grade-3-associated-with-beh%C3%A3-et-s-disease
#15
Daphné Germann, Rosa Catarino, Essia Saiji, Thomas Daikeler, Patrick Petignat, Pierre Vassilakos
BACKGROUND: Little information is available regarding the association between vulvar intraepithelial neoplasia grade 3 (VIN3) and Behçet's disease (BD). We report here concomitant VIN3 and genital ulcers in a patient with BD. CASE: A 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. Biopsies revealed a multifocal VIN3 positive for high-risk human papillomavirus (HPV) 33...
March 17, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26974999/the-natural-history-of-vulvar-intraepithelial-neoplasia-differentiated-type-evidence-for-progression-and-diagnostic-challenges
#16
Susan M Bigby, Lois J Eva, Kah Leng Fong, Ronald W Jones
Squamous cell carcinoma of the vulva (SCCV) develops through either human papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% of SCCV arise independently of HPV, commonly in a background of an inflammatory dermatosis, particularly lichen sclerosus. The likely direct precursor to most of these lesions is vulvar intraepithelial neoplasia (VIN), differentiated type (dVIN), although the evidence is largely circumstantial. There are few reports of progression to carcinoma, and the natural history of this pathway is not well understood...
November 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26942352/the-2015-international-society-for-the-study-of-vulvovaginal-disease-issvd-terminology-of-vulvar-squamous-intraepithelial-lesions
#17
Jacob Bornstein, Fabrizio Bogliatto, Hope K Haefner, Colleen K Stockdale, Mario Preti, Tanja G Bohl, Jason Reutter
OBJECTIVES: The impact of terminology for vulvar intraepithelial lesions has been significant over the years, because it has affected diagnosis, treatment, and research. The introduction of the Lower Anogenital Squamous Terminology (LAST) in 2012 raised 2 concerns in relation to vulvar lesions: firstly, the absence of reference to "differentiated vulvar intraepithelial neoplasia" (differentiated VIN) could lead to its being overlooked by health care providers, despite its malignant potential...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26332918/application-of-a-thulium-laser-for-treatment-of-cervical-neoplasias-and-condylomas-a-feasibility-study
#18
Melanie Henes, Bernhard Vogt, Felix Neis, Katharina Rall, Tanja Litzenburger, Diethelm Wallwiener, Sara Y Brucker, Ralf Rothmund
OBJECTIVE: Evaluation of safety, feasibility, and possibilities of the thulium laser, Vela(®), with a wavelength of 1.9 μm for laser treatment of the portio, vagina, and/or vulva. BACKGROUND DATA: Laser techniques have been used for many years in the gynecological setting for the treatment of cervical, vaginal, and vulval intraepithelial neoplasias (CIN, VAIN, VIN) and also for the treatment of condylomas. To date, the most commonly used laser for this treatment is the CO2 laser...
September 2015: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/26174756/photodynamic-therapy-for-premalignant-lesions-of-the-vulva-and-vagina-a-long-term-follow-up-study
#19
Min Chul Choi, Mi Sun Kim, Gee Hoon Lee, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee, Yoon Young Hwang, Seung Jo Kim
BACKGROUND AND OBJECTIVE: We aimed to evaluate responses to photodynamic therapy (PDT) and its long-term efficacy in preserving normal anatomy and function in women with premalignant lesions of the lower genital tract. STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients received PDT for vulvar intraepithelial neoplasia (VIN), vaginal intraepithelial neoplasia (VAIN), or vulvar Paget's disease between January 2003 and December 2013. Patients underwent colposcopy and/or vulvoscopy for assessment of lesions...
July 14, 2015: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/26171917/squamous-cell-carcinoma-of-the-vulva-a-subclassification-of-97-cases-by-clinicopathologic-immunohistochemical-and-molecular-features-p16-p53-and-egfr
#20
Fei Dong, Sakiko Kojiro, Darrell R Borger, Whitfield B Growdon, Esther Oliva
Squamous cell carcinomas (SCCs) of the vulva develop through human papilloma virus (HPV)-associated or HPV-independent pathways, but the relationship between pathogenesis, classification, and prognosis of these tumors is controversial. Therefore, we review the morphology, immunophenotype, and select molecular features of a consecutive series of 97 patients with vulvar SCC with a median clinical follow-up of 3.6 years. Tumors were histologically classified as basaloid (13), warty (11), mixed basaloid and warty (1), keratinizing (68), nonkeratinizing (3), and sarcomatoid (1)...
August 2015: American Journal of Surgical Pathology
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