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vulva intraepithelial neoplasia

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https://www.readbyqxmd.com/read/28398952/vulvar-and-anal-intraepithelial-neoplasia-terminology-diagnosis-and-ancillary-studies
#1
REVIEW
Eric J Yang, Christina S Kong, Teri A Longacre
Currently, it is recognized that there is an HPV-related and an HPV-independent pathway to developing squamous cell carcinomas (SCC) in the anus and vulva. The majority of precursor lesions and SCC in the anus and vulva are high-risk HPV-associated, with HPV16 the most common type. Given the morphologic overlap and biological equivalence of HPV-related preinvasive squamous lesions of the lower anogenital tract, a unified, 2-tiered histopathologic nomenclature is now recommended. In contrast, mutations in the TP53 gene have been associated with HPV-independent vulvar and anal SCC...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28349118/vulvar-condylomatosis-after-sex-reassignment-surgery-in-a-male-to-female-transsexual-complete-response-to-imiquimod-cream
#2
Trinidad Labanca, Ivan Mañero
BACKGROUND: The number of patients seeking sex reassignment surgery is increasing. Approximately 1:30,000 adult males and 1: 100,000 adult females seek this procedure. Neovaginal-related disorders after sex reassignment surgery are increasingly more common. Vulvar condylomatosis is the clinical manifestation of HPV 6- and 11 infection in biological women. The same HPV-subtypes are associated with anogenital warts and penile intraepithelial neoplasia in biological men. We aim to present a case of vulvar condylomatosis after sex reassignment surgery in a male-to-female transsexual and its complete response to 5% imiquimod cream...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28293790/deconstructing-the-genitourinary-syndrome-of-menopause
#3
Pedro Vieira-Baptista, Claudia Marchitelli, Hope K Haefner, Gilbert Donders, Faustino Pérez-López
The concept of genitourinary syndrome of menopause (GSM) was recently introduced and has been gaining widespread use. While some justifications for its introduction are straightforward, others may be questionable. Numerous unspecific symptoms and signs were included in the definition of the syndrome, but the minimum number required for diagnosis was not established. While the GSM definition is designed to facilitate identifying vulvovaginal and urinary estrogen-deprivation-associated symptoms and signs, several concerns have evolved: (1) the syndrome may result in the underdiagnosis of vulvar and urinary pathology; and (2) serious conditions (e...
March 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/27998445/-progression-of-vulva-intraepithelial-neoplasia-grade-%C3%A2-to-vulva-cancer-a-case-report
#4
W H Zhang, P Bai, S M Li, H Sun
No abstract text is available yet for this article.
November 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#5
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27661656/committee-opinion-no-675-management-of-vulvar-intraepithelial-neoplasia
#6
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27661648/committee-opinion-no-675-summary-management-of-vulvar-intraepithelial-neoplasia
#7
(no author information available yet)
Vulvar intraepithelial neoplasia (VIN) is an increasingly common problem, particularly among women in their 40s. Although spontaneous regression has been reported, VIN should be considered a premalignant condition. Immunization with the quadrivalent or 9-valent human papillomavirus vaccine, which is effective against human papillomavirus genotypes 6, 11, 16, and 18, and 6, 11, 16, 18, 31, 33, 45, 52, and 58, respectively, has been shown to decrease the risk of vulvar high-grade squamous intraepithelial lesion (HSIL) (VIN usual type) and should be recommended for girls aged 11-12 years with catch-up through age 26 years if not vaccinated in the target age...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27113549/squamous-precursor-lesions-of-the-vulva-current-classification-and-diagnostic-challenges
#8
REVIEW
Lien N Hoang, Kay J Park, Robert A Soslow, Rajmohan Murali
Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. In contrast, VIN of differentiated type (dVIN) occurs in post-menopausal women and develops independent of HPV infection...
June 2016: Pathology
https://www.readbyqxmd.com/read/26983442/vulvar-intraepithelial-neoplasia-grade-3-associated-with-beh%C3%A3-et-s-disease
#9
Daphné Germann, Rosa Catarino, Essia Saiji, Thomas Daikeler, Patrick Petignat, Pierre Vassilakos
BACKGROUND: Little information is available regarding the association between vulvar intraepithelial neoplasia grade 3 (VIN3) and Behçet's disease (BD). We report here concomitant VIN3 and genital ulcers in a patient with BD. CASE: A 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. Biopsies revealed a multifocal VIN3 positive for high-risk human papillomavirus (HPV) 33...
March 17, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26974999/the-natural-history-of-vulvar-intraepithelial-neoplasia-differentiated-type-evidence-for-progression-and-diagnostic-challenges
#10
Susan M Bigby, Lois J Eva, Kah Leng Fong, Ronald W Jones
Squamous cell carcinoma of the vulva (SCCV) develops through either human papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% of SCCV arise independently of HPV, commonly in a background of an inflammatory dermatosis, particularly lichen sclerosus. The likely direct precursor to most of these lesions is vulvar intraepithelial neoplasia (VIN), differentiated type (dVIN), although the evidence is largely circumstantial. There are few reports of progression to carcinoma, and the natural history of this pathway is not well understood...
November 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26942352/the-2015-international-society-for-the-study-of-vulvovaginal-disease-issvd-terminology-of-vulvar-squamous-intraepithelial-lesions
#11
Jacob Bornstein, Fabrizio Bogliatto, Hope K Haefner, Colleen K Stockdale, Mario Preti, Tanja G Bohl, Jason Reutter
OBJECTIVES: The impact of terminology for vulvar intraepithelial lesions has been significant over the years, because it has affected diagnosis, treatment, and research. The introduction of the Lower Anogenital Squamous Terminology (LAST) in 2012 raised 2 concerns in relation to vulvar lesions: firstly, the absence of reference to "differentiated vulvar intraepithelial neoplasia" (differentiated VIN) could lead to its being overlooked by health care providers, despite its malignant potential...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26332918/application-of-a-thulium-laser-for-treatment-of-cervical-neoplasias-and-condylomas-a-feasibility-study
#12
Melanie Henes, Bernhard Vogt, Felix Neis, Katharina Rall, Tanja Litzenburger, Diethelm Wallwiener, Sara Y Brucker, Ralf Rothmund
OBJECTIVE: Evaluation of safety, feasibility, and possibilities of the thulium laser, Vela(®), with a wavelength of 1.9 μm for laser treatment of the portio, vagina, and/or vulva. BACKGROUND DATA: Laser techniques have been used for many years in the gynecological setting for the treatment of cervical, vaginal, and vulval intraepithelial neoplasias (CIN, VAIN, VIN) and also for the treatment of condylomas. To date, the most commonly used laser for this treatment is the CO2 laser...
September 2015: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/26174756/photodynamic-therapy-for-premalignant-lesions-of-the-vulva-and-vagina-a-long-term-follow-up-study
#13
Min Chul Choi, Mi Sun Kim, Gee Hoon Lee, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee, Yoon Young Hwang, Seung Jo Kim
BACKGROUND AND OBJECTIVE: We aimed to evaluate responses to photodynamic therapy (PDT) and its long-term efficacy in preserving normal anatomy and function in women with premalignant lesions of the lower genital tract. STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients received PDT for vulvar intraepithelial neoplasia (VIN), vaginal intraepithelial neoplasia (VAIN), or vulvar Paget's disease between January 2003 and December 2013. Patients underwent colposcopy and/or vulvoscopy for assessment of lesions...
July 14, 2015: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/26171917/squamous-cell-carcinoma-of-the-vulva-a-subclassification-of-97-cases-by-clinicopathologic-immunohistochemical-and-molecular-features-p16-p53-and-egfr
#14
Fei Dong, Sakiko Kojiro, Darrell R Borger, Whitfield B Growdon, Esther Oliva
Squamous cell carcinomas (SCCs) of the vulva develop through human papilloma virus (HPV)-associated or HPV-independent pathways, but the relationship between pathogenesis, classification, and prognosis of these tumors is controversial. Therefore, we review the morphology, immunophenotype, and select molecular features of a consecutive series of 97 patients with vulvar SCC with a median clinical follow-up of 3.6 years. Tumors were histologically classified as basaloid (13), warty (11), mixed basaloid and warty (1), keratinizing (68), nonkeratinizing (3), and sarcomatoid (1)...
August 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25930015/vulvar-cancer-a-review-for-dermatologists
#15
REVIEW
Anastasiya Atanasova Chokoeva, Georgi Tchernev, Elena Castelli, Elisabetta Orlando, Shyam B Verma, Markus Grebe, Uwe Wollina
Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies.Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2% of all vulvar cancers...
April 2015: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25797230/prevalence-of-anal-human-papillomavirus-infection-and-anal-hpv-related-disorders-in-women-a-systematic-review
#16
REVIEW
Elizabeth A Stier, Meagan C Sebring, Audrey E Mendez, Fatimata S Ba, Debra D Trimble, Elizabeth Y Chiao
The aim of this study was to systematically review the findings of publications addressing the epidemiology of anal human papillomavirus (HPV) infection, anal intraepithelial neoplasia, and anal cancer in women. We conducted a systematic review among publications published from Jan. 1, 1997, to Sept. 30, 2013, to limit to publications from the combined antiretroviral therapy era. Three searches were performed of the National Library of Medicine PubMed database using the following search terms: women and anal HPV, women anal intraepithelial neoplasia, and women and anal cancer...
September 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25697926/colposcopic-acetowhitening-of-vulvar-lesion-a-validity-study
#17
Joseph T Santoso, Wendy Likes
OBJECTIVE: To evaluate the acetowhite changes of the vulva as a predictor for high grade vulvar intraepithelial neoplasia. METHODS: We performed retrospective analysis from 344 patients referred to our gynecology oncology clinic for genital dysplasia. All patients underwent vulvar colposcopy. Vulvar biopsies were performed for acetowhite changes and visible vulvar lesions such as ulceration, hyperpigmentation, and thickening of the vulvar tissue. High grade vulvar dysplasia was defined as vulvar intraepithelial neoplasia 2 or worse...
August 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25664114/viral-dna-load-of-high-risk-human-papilloma-virus-is-closely-associated-with-the-grade-of-cervical-lesions
#18
Guqun Shen, Jingxin Cheng, Yan Wang, Ping Zhou, Guoqing Zhang
This study is to explore the correlation between the viral load of high-risk human papilloma virus (HPV) and the degree of cervical lesions, as well as the follow-up monitoring role of high-risk HPV measurements in the treatment of patients with cervical lesions. Hybrid capture-2 method was used to measure the amount of high-risk HPV load of 361 patients who were enrolled from January 2009 to December 2010 at the Affiliated Tumor Hospital of Xinjiang Medical University, including 76 cases of cervical squamous carcinoma, 119 cases of cervical intraepithelial neoplasia and 166 cases of cervicitis...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25510069/-diagnosis-and-treatment-of-lichen-sclerosus-review
#19
REVIEW
A Ganovska, S Kovachev, A Nikolov
UNLABELLED: Lichen sclerosus (LS) is a chronic skin disease of the vulva which affects mostly women in the postmenopausal period. The disease affects also men and children. Its frequency is from 1/70 up to 1/1000, whereas for women it is 10 times more frequently. The disease has unknown etiology. Due to the high frequency of accompanying, autoimmune diseases, it is presumed that this disease is a result of immunological processes. Some of patients diagnosed with LS have vulvar intraepithelial neoplasia, while 0...
2014: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/25472459/-extramammary-paget%C3%A2-s-disease-of-the-vulva-a-case-report
#20
D Kolářová, A Havránková, P Líbalová, S Frühaufová, Z Vernerová, E Kučera
OBJECTIVE: Analysis of one case of vulvar extramammary Paget´s disease (EMPD) and associated well differentiated endometrial adenocarcinoma.Desing: A case report. METHODS AND RESULTS: On this case report we present current theoretical knowledge about EMPD, difficulty of diagnostics, treatment and dispensarization the patients with this rare intraepithelial non-squamous neoplasia. We report a rare case of a 62 years old female patient with extramammary Paget´s disease of vulva and associated well differentiated endometrial adenocarcinoma...
November 2014: Ceská Gynekologie
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