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hsp70 interacting protein

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https://www.readbyqxmd.com/read/29777767/biglycan-is-a-new-high-affinity-ligand-for-cd14-in-macrophages
#1
Heiko Roedig, Madalina V Nastase, Helena Frey, Kristin Moreth, Jinyang Zeng-Brouwers, Chiara Poluzzi, Louise Tzung-Harn Hsieh, Christian Brandts, Simone Fulda, Malgorzata Wygrecka, Liliana Schaefer
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Biglycan, a prototype extracellular matrix-derived damage-associated molecular pattern, mediates sterile inflammation in macrophages through Toll-like receptor (TLR) 2 and/or TLR4-dependent signaling pathways. Here we discovered that soluble biglycan is a novel high-affinity ligand for CD14, a well-known GPI-anchored co-receptor for TLRs...
May 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29765493/long-term-exercise-protects-against-cellular-stresses-in-aged-mice
#2
Irina Belaya, Masataka Suwa, Tao Chen, Rashid Giniatullin, Katja M Kanninen, Mustafa Atalay, Shuzo Kumagai
The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice. Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups. The OE group started voluntary wheel-running at 3 months and continued until 24 months of age. Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio-a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29764935/the-disorderly-conduct-of-hsc70-and-its-interaction-with-the-alzheimer-s-related-tau-protein
#3
Isabelle R Taylor, Atta Ahmad, Taia Wu, Bryce A Nordhues, Anup Bhullar, Jason E Gestwicki, Erik R P Zuiderweg
Hsp70 chaperones bind to various protein substrates for folding, trafficking, and degradation. Considerable structural information is available about how prokaryotic Hsp70 (DnaK) binds substrates, but less is known about mammalian Hsp70s, of which there are 13 isoforms encoded in the human genome. Here, we report the interaction between the human Hsp70 isoform heat shock cognate 71 KDa protein (Hsc70 or HSPA8) and peptides derived from the microtubule-associated protein tau, which is linked to Alzheimer's disease...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29764864/targeting-the-hsp40-hsp70-chaperone-axis-as-a-novel-strategy-to-treat-castration-resistant-prostate-cancer
#4
Michael A Moses, Yeong Sang Kim, Genesis M Rivera-Marquez, Nobu Oshima, Matthew J Watson, Kristin Beebe, Catherine Wells, Sunmin Lee, Abbey D Zuehlke, Hao Shao, William E Bingman, Vineet Kumar, Sanjay Malhotra, Nancy L Weigel, Jason E Gestwicki, Jane Trepel, Leonard M Neckers
Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen receptor (AR) signaling in part by elevated expression of AR splice variants (ARv) including ARv7, a constitutively active, ligand binding domain (LBD)-deficient variant whose expression has been correlated with therapeutic resistance and poor prognosis. In a screen to identify small molecule dual inhibitors of both androgen-dependent and androgen-independent AR gene signatures, we identified the chalcone C86. Binding studies using purified proteins and CRPC cell lysates revealed C86 to interact with heat shock protein 40 (Hsp40)...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29738871/identification-of-litopenaeus-vannamei-bip-as-a-novel-cellular-attachment-protein-for-white-spot-syndrome-virus-by-using-a-biotinylation-based-affinity-chromatography-method
#5
Zengzhi Yuan, Meng Chen, Jingting Wang, Zhuoyu Li, Xuyun Geng, Jinsheng Sun
White spot syndrome virus (WSSV) is a dangerous threat to shrimp farming that also attacks a wide range of crustaceans. Knowledge of the surface protein-protein interactions between the pathogen and host is very crucial to unraveling the molecular pathogenesis mechanisms of WSSV. In this study, LvBiP (Litopenaeus vannamei immunoglobulin heavy-chain-binding protein) was identified as a novel WSSV binding protein of L. vannamei by a biotinylation based affinity chromatography method. By using pull-down and ELISA assays, the binding of recombinant LvBiP to WSSV was proved to be specific and ATP- dependent...
May 5, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29735737/intra-molecular-pathways-of-allosteric-control-in-hsp70s
#6
REVIEW
Matthias P Mayer
The 70 kDa heat-shock protein (Hsp70) is undoubtedly the most versatile of all molecular chaperones. Hsp70 is involved in numerous cellular protein folding processes, accompanying proteins throughout their lifespan from de novo folding at the ribosome to degradation at the proteasome, surveilling protein stability and functionality. Several properties of this ATP-dependent chaperone constitute the molecular basis for this versatility. With its substrate binding domain (SBD), Hsp70 transiently interacts with a short degenerative linear sequence motif found practically in all proteins and, in addition, with more folded protein conformers...
June 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29733960/effects-of-dietary-glucose-and-starch-levels-on-the-growth-apparent-digestibility-and-skin-associated-mucosal-non-specific-immune-parameters-in-juvenile-blunt-snout-bream-megalobrama-amblycephala
#7
Si-Lei Xia, Xiang-Fei Li, Kenneth Prudence Abasubong, Chao Xu, Hua-Juan Shi, Wen-Bin Liu, Ding-Dong Zhang
A 10-week feeding trial was performed to evaluate the effects of different types and levels of carbohydrates in growth performance, apparent digestibility coefficients and skin-associated mucosal non-specific immune parameters in blunt snout bream (Megalobrama amblycephala). Fish were randomly fed four diets containing two carbohydrates (glucose and starch) diets and two carbohydrates levels (330 and 440 g kg-1 ). High carbohydrate levels remarkably increased the weight gain rate (WGR), apparent digestibility of dry matters, protein and carbohydrates, body crud protein content, plasma levels of aspartate transaminase (AST), and skin-associated mucosal levels of immunoglobulin M (IgM), HDL cholesterol, lysozyme (LZM), advanced the transcriptions of mucin 2 (Muc2), mucin 5b (Muc5b) and apolipoprotein A-I (apoA-I), whereas the opposite was true for feed conversion ratio (FCR), plasma levels of IgM, skin-associated mucosal levels of major histocompatibility complex (MHC) and β-Defensins, and the transcriptions of heat shock protein 60 (Hsp60)...
May 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29725069/hsp90-inhibitors-disrupt-a-transient-hsp90-hsf1-interaction-and-identify-a-noncanonical-model-of-hsp90-mediated-hsf1-regulation
#8
Toshiki Kijima, Thomas L Prince, Megan L Tigue, Kendrick H Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A Budzynski, Heinric Williams, Jane B Trepel, Lea Sistonen, Stuart Calderwood, Len Neckers
Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program. HSF1 is thought to be regulated by molecular chaperones, including Heat Shock Protein 90 (HSP90). HSP90 is proposed to sequester HSF1 in unstressed cells, but visualization of this interaction in vivo requires protein crosslinking. In this report, we show that HSP90 binding to HSF1 depends on HSP90 conformation and is only readily visualized for the ATP-dependent, N-domain dimerized chaperone, a conformation only rarely sampled by mammalian HSP90...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29722824/glutathione-modulates-the-expression-of-heat-shock-proteins-via-bzip10-and-myb21-transcription-factors-in-arabidopsis-thaliana
#9
Deepak Kumar, Sharmila Chattopadhyay
The contribution of glutathione (GSH) in combating environmental stress in the plant system has long been known. Previous reports also pointed towards the involvement of GSH in inducing various heat shock proteins (HSPs). However, the molecular mechanism is yet to be explored. Here, we investigate how GSH induces the expression of important HSPs in Arabidopsis thaliana. Expressions of HSPs like BiP3, HSP70B and HSP90.1 were positively regulated by GSH. Promoter activation assay suggested the role of GSH in inducing these HSPs...
May 2, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29721967/the-leber-congenital-amaurosis-linked-protein-aipl1-and-its-critical-role-in-photoreceptors
#10
Almudena Sacristan-Reviriego, Jacqueline van der Spuy
Mutations in the photoreceptor/pineal-expressed gene, aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), are mainly associated with autosomal recessive Leber congenital amaurosis (LCA), the most severe form of inherited retinopathy that occurs in early childhood. AIPL1 functions as a photoreceptor-specific molecular co-chaperone that interacts specifically with the molecular chaperones HSP90 and HSP70 to facilitate the correct folding and assembly of the retinal cGMP phosphodiesterase (PDE6) holoenzyme...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29714053/sulforaphane-upregulates-the-heat-shock-protein-co-chaperone-chip-and-clears-amyloid-%C3%AE-and-tau-in-a-mouse-model-of-alzheimer-s-disease
#11
Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, we investigated whether sulforaphane modulates the production of amyloid-β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD). METHODS AND RESULTS: A triple transgenic mouse model of AD (3 × Tg-AD) was used to study the effect of sulforaphane. Oral gavage of sulforaphane reduced protein levels of monomeric and polymeric forms of Aβ as well as tau and phosphorylated tau in 3 × Tg-AD mice...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29704317/development-of-gmp-1-a-molecular-chaperone-network-modulator-protecting-mitochondrial-function-and-its-assessment-in-fly-and-mice-models-of-alzheimer-s-disease
#12
Pavel F Pavlov, Birgit Hutter-Paier, Daniel Havas, Manfred Windisch, Bengt Winblad
Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD) and may play an important role in the pathogenesis of disease. It has been shown that amyloid beta peptide (Aβ) and amyloid precursor protein (APP) interact with mitochondria contributing to the mitochondrial dysfunction in AD. Prevention of abnormal protein targeting to mitochondria can protect normal mitochondrial function, increase neuronal survival and at the end, ameliorate symptoms of AD and other neurodegenerative disorders. First steps of mitochondrial protein import are coordinated by molecular chaperones Hsp70 and Hsp90 that bind to the newly synthesized mitochondria-destined proteins and deliver them to the protein import receptors on the surface of organelle...
April 27, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29689729/memory-loss-and-the-onset-of-alzheimer-s-disease-could-be-under-the-control-of-extracellular-heat-shock-proteins
#13
Nelson Arispe, Antonio De Maio
Alzheimer's disease (AD) is a major contemporary and escalating malady in which amyloid-β (Aβ) peptides are the most likely causative agent. Aβ peptides spontaneously tend to aggregate in extracellular fluids following a progression from a monomeric state, through intermediate forms, ending in amyloid fibers and plaques. It is generally accepted now that the neurotoxic agents leading to cellular death, memory loss, and other AD characteristics are the Aβ intermediate aggregated states. However, Aβ peptides are continuously produced, released into the extracellular space, and rapidly cleared from healthy brains...
April 17, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29686000/angiotensin-ii-promotes-k-v-7-4-channels-degradation-through-reduced-interaction-with-hsp90-heat-shock-protein-90
#14
Vincenzo Barrese, Jennifer B Stott, Hericka B Figueiredo, Aisah A Aubdool, Adrian J Hobbs, Thomas A Jepps, Alister J McNeish, Iain A Greenwood
Voltage-gated Kv 7.4 channels have been implicated in vascular smooth muscle cells' activity because they modulate basal arterial contractility, mediate responses to endogenous vasorelaxants, and are downregulated in several arterial beds in different models of hypertension. Angiotensin II (Ang II) is a key player in hypertension that affects the expression of several classes of ion channels. In this study, we evaluated the effects of Ang II on the expression and function of vascular Kv 7.4. Western blot and quantitative polymerase chain reaction revealed that in whole rat mesenteric artery, Ang II incubation for 1 to 7 hours decreased Kv 7...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29685889/wwp2-is-a-physiological-ubiquitin-ligase-for-phosphatase-and-tensin-homolog-pten-in-mice
#15
Hongchang Li, Pengfei Zhang, Qiuyue Zhang, Chaonan Li, Weiguo Zou, Zhijie Chang, Chun-Ping Cui, Lingqiang Zhang
The tumor suppressor phosphatase and tensin homolog (PTEN) plays a central role in regulating phosphatidylinositol-3-kinase (PI3K) signaling, and its gene is very frequently mutated in various human cancers. Numerous studies have revealed that PTEN levels are tightly regulated by both transcriptional and post-translational modifications, with especially ubiquitylation significantly regulating PTEN protein levels. Although several ubiquitin ligases have been reported to mediate PTEN ubiquitylation in vitro , the ubiquitin ligase that promotes PTEN degradation in vivo has not been reported...
April 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29684060/moyvh1-subverts-rice-defense-through-functions-of-ribosomal-protein-momrt4-in-magnaporthe-oryzae
#16
Xinyu Liu, Jie Yang, Bin Qian, Yongchao Cai, Xi Zou, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang
The accumulation of the reactive oxygen species (ROS) in rice is important in its interaction with the rice blast fungus Magnaporthe oryzae during which the pathogen scavenges ROS through the production of extracellular enzymes that promote blast. We previously characterized the MoYvh1 protein phosphatase from M. oryzae that plays a role in scavenging of ROS. To understand the underlying mechanism, we found that MoYvh1 is translocated into the nucleus following oxidative stress and that this translocation is dependent on MoSsb1 and MoSsz1 that are homologous to heat-shock protein 70 (Hsp70) proteins...
April 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29682607/the-role-of-hsp40-conserved-motifs-in-the-response-to-cytotoxic-stress
#17
Samantha J Sojourner, Willie M Graham, Aurellia M Whitmore, Jana S Miles, Devon Freeny, Hernan Flores-Rozas
Doxorubicin, a highly effective therapeutic agent against several types of cancer, is associated with serious side-effects, particularly cardiotoxicity. In addition, drug resistance leads to unsuccessful outcomes in many patients. There are no current biomarkers to indicate doxorubicin treatment response in patients. To understand the mechanisms of toxicity of doxorubicin, a whole-genome sensitivity screen was performed in the yeast S. cerevisiae . A deletion mutant of the yeast DNAJ (YDJ1), a J-domain heat-shock protein 40 (HSP40) was among the most sensitive strains...
2018: Journal of Nature and Science
https://www.readbyqxmd.com/read/29659649/systems-analysis-of-the-genetic-interaction-network-of-yeast-molecular-chaperones
#18
Kamran Rizzolo, Ashwani Kumar, Yoshito Kakihara, Sadhna Phanse, Zoran Minic, Jamie Snider, Igor Stagljar, Sandra Zilles, Mohan Babu, Walid A Houry
Molecular chaperones are typically promiscuous interacting proteins that function globally in the cell to maintain protein homeostasis. Recently, we had carried out experiments that elucidated a comprehensive interaction network for the core 67 chaperones and 15 cochaperones in the budding yeast Saccharomyces cerevisiae [Rizzolo et al., Cell Rep., 2017, 20, 2735-2748]. Here, the genetic (i.e. epistatic) interaction network obtained for chaperones was further analyzed, revealing that the global topological parameters of the resulting network have a more central role in mediating interactions in comparison to the rest of the proteins in the cell...
April 16, 2018: Molecular omics
https://www.readbyqxmd.com/read/29657812/resurrected-ancient-daphnia-genotypes-show-reduced-thermal-stress-tolerance-compared-to-modern-descendants
#19
Aime'e M Yousey, Priyanka Roy Chowdhury, Nicole Biddinger, Jennifer H Shaw, Punidan D Jeyasingh, Lawrence J Weider
Understanding how populations adapt to rising temperatures has been a challenge in ecology. Research often evaluates multiple populations to test whether local adaptation to temperature regimes is occurring. Space-for-time substitutions are common, as temporal constraints limit our ability to observe evolutionary responses. We employed a resurrection ecology approach to understand how thermal tolerance has changed in a Daphnia pulicaria population over time. Temperatures experienced by the oldest genotypes were considerably lower than the youngest...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29651044/yeast-aconitase-mitochondrial-import-is-modulated-by-interactions-of-its-c-and-n-terminal-domains-and-ssa1-2-hsp70
#20
Reut Ben-Menachem, Katherine Wang, Orly Marcu, Zhang Yu, Teck Kwang Lim, Qingsong Lin, Ora Schueler-Furman, Ophry Pines
Molecules of single proteins, echoforms, can be distributed between two (or more) subcellular locations, a phenomenon which we refer to as dual targeting or dual localization. The yeast aconitase gene ACO1 (778 amino acids), encodes a single translation product that is nonetheless dual localized to the cytosol and mitochondria by a reverse translocation mechanism. The solved crystal structure of aconitase isolated from porcine heart mitochondria shows that it has four domains. The first three tightly associated N-terminal domains are tethered to the larger C-terminal fourth domain (C-terminal amino acids 517-778)...
April 12, 2018: Scientific Reports
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