keyword
MENU ▼
Read by QxMD icon Read
search

Dlx3

keyword
https://www.readbyqxmd.com/read/27777986/transcription-factor-dlx3-induces-aryl-hydrocarbon-receptor-promoter-activity
#1
June Ho Shin, Mikel D Haggadone, John B Sunwoo
The Distal-less (Dlx) homeobox transcription factors (TFs) play a prominent role in regulating multiple facets of vertebrate biology. Though widely studied as mediators of tissue development, recent work has uncovered a role for this TF family in modulating the vertebrate hematopoietic compartment. Pertinent to our study, murine Dlx1-3 are expressed in an innate lymphocyte population known as natural killer (NK) cells, and they are implicated to assume a functional role in the NK cell maturation pathway. However, Dlx target genes are poorly understood...
September 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/27760456/dlx3-dependent-regulation-of-ion-transporters-and-carbonic-anhydrases-is-crucial-for-enamel-mineralization
#2
Olivier Duverger, Takahiro Ohara, Paul W Bible, Angela Zah, Maria I Morasso
Patients with Tricho-Dento-Osseous syndrome, an ectodermal dysplasia caused by mutations in the homeodomain transcription factor DLX3, exhibit enamel hypoplasia and hypomineralization. Here we used a conditional knockout mouse model to investigate the developmental and molecular consequences of Dlx3 deletion in the dental epithelium in vivo. Dlx3 deletion in the dental epithelium resulted in the formation of chalky hypomineralized enamel in all teeth. Interestingly, transcriptomic analysis revealed that major enamel matrix proteins and proteases known to be involved in enamel secretion and maturation were not affected significantly by Dlx3 deletion in the enamel organ...
October 19, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27562213/varprism-incorporating-variant-prioritization-in-tests-of-de-novo-mutation-association
#3
Hao Hu, Hilary Coon, Man Li, Mark Yandell, Chad D Huff
BACKGROUND: Patients with certain genetic diseases, such as autism spectrum disorder, have increased rates of de novo mutations within some protein-coding genes. RESULTS: We introduce the VARiant PRIoritization SuM (VARPRISM), a software package which incorporates functional variant prioritization information to improve the power to detect de novo mutations influencing disease risk. VARPRISM evaluates the consequence of any given exonic mutation on the protein sequence to estimate the likelihood that the mutation is benign or damaging and conducts a likelihood ratio test on the gene level...
2016: Genome Medicine
https://www.readbyqxmd.com/read/27521061/expression-patterns-of-homeobox-genes-in-the-mouse-vomeronasal-organ-at-postnatal-stages
#4
Isabelle Chang, Marta Parrilla
Homeodomain proteins are encoded by homeobox genes and regulate development and differentiation in many neuronal systems. The mouse vomeronasal organ (VNO) generates in situ mature chemosensory neurons from stem cells. The roles of homeodomain proteins in neuronal differentiation in the VNO are poorly understood. Here we have characterized the expression patterns of 28 homeobox genes in the VNO of C57BL/6 mice at postnatal stages using multicolor fluorescent in situ hybridization. We identified 11 homeobox genes (Dlx3, Dlx4, Emx2, Lhx2, Meis1, Pbx3, Pknox2, Pou6f1, Tshz2, Zhx1, Zhx3) that were expressed exclusively in neurons; 4 homeobox genes (Pax6, Six1, Tgif1, Zfhx3) that were expressed in all non-neuronal cell populations, with Pax6, Six1 and Tgif1 also expressed in some neuronal progenitors and precursors; 12 homeobox genes (Adnp, Cux1, Dlx5, Dlx6, Meis2, Pbx2, Pknox1, Pou2f1, Satb1, Tshz1, Tshz3, Zhx2) with expression in both neuronal and non-neuronal cell populations; and one homeobox gene (Hopx) that was exclusively expressed in the non-sensory epithelium...
July 2016: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/27368119/the-parathyroid-hormone-related-protein-is-secreted-during-the-osteogenic-differentiation-of-human-dental-follicle-cells-and-inhibits-the-alkaline-phosphatase-activity-and-the-expression-of-dlx3
#5
C Klingelhöffer, A Reck, T Ettl, C Morsczeck
The dental follicle is involved in tooth eruption and it expresses a great amount of the parathyroid hormone-related protein (PTHrP). PTHrP as an extracellular protein is required for a multitude of different regulations of enchondral bone development and differentiation of bone precursor cells and of the development of craniofacial tissues. The dental follicle contains also precursor cells (DFCs) of the periodontium. Isolated DFCs differentiate into periodontal ligament cells, alveolar osteoblast and cementoblasts...
August 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27243442/expression-of-homeobox-genes-in-the-mouse-olfactory-epithelium
#6
Marta Parrilla, Isabelle Chang, Andrea Degl'Innocenti, Masayo Omura
Homeobox genes constitute a large family of genes widely studied because of their role in the establishment of the body pattern. However, they are also involved in many other events during development and adulthood. The main olfactory epithelium (MOE) is an excellent model to study neurogenesis in the adult nervous system. Analyses of homeobox genes during development show that some of these genes are involved in the formation and establishment of cell diversity in the MOE. Moreover, the mechanisms of expression of odorant receptors (ORs) constitute one of the biggest enigmas in the field...
October 1, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27179118/family-based-genetic-association-for-molar-incisor-hypomineralization
#7
Fabiano Jeremias, Ricardo A G Pierri, Juliana F Souza, Camila Maria B Fragelli, Manuel Restrepo, Livia S Finoti, Diego G Bussaneli, Rita C L Cordeiro, Rodrigo Secolin, Claudia V Maurer-Morelli, Raquel M Scarel-Caminaga, Lourdes Santos-Pinto
Despite some evidence of genetic and environmental factors on molar-incisor hypomineralization (MIH), its aetiology remains unclear. This family-based genetic association study aimed more comprehensively to investigate the genetic carriage potentially involved in MIH development. DNA was obtained from buccal cells of 391 individuals who were birth family members of 101 Brazilian nuclear families. Sixty-three single nucleotide polymorphisms (SNPs) were investigated in 21 candidate genes related to amelogenesis using the TaqMan™ OpenArray™ Genotyping platform...
2016: Caries Research
https://www.readbyqxmd.com/read/26921333/mutational-landscape-and-antiproliferative-functions-of-elf-transcription-factors-in-human-cancer
#8
Mizuo Ando, Masahito Kawazu, Toshihide Ueno, Daizo Koinuma, Koji Ando, Junji Koya, Keisuke Kataoka, Takahiko Yasuda, Hiroyuki Yamaguchi, Kazutaka Fukumura, Azusa Yamato, Manabu Soda, Eirin Sai, Yoshihiro Yamashita, Takahiro Asakage, Yasushi Miyazaki, Mineo Kurokawa, Kohei Miyazono, Stephen D Nimer, Tatsuya Yamasoba, Hiroyuki Mano
ELF4 (also known as MEF) is a member of the ETS family of transcription factors. An oncogenic role for ELF4 has been demonstrated in hematopoietic malignancies, but its function in epithelial tumors remains unclear. Here, we show that ELF4 can function as a tumor suppressor and is somatically inactivated in a wide range of human tumors. We identified a missense mutation affecting the transactivation potential of ELF4 in oral squamous cell carcinoma cells. Restoration of the transactivation activity through introduction of wild-type ELF4 significantly inhibited cell proliferation in vitro and tumor xenograft growth...
April 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26907377/abnormal-labyrinthine-zone-in-the-hectd1-null-placenta
#9
Anjali A Sarkar, Julia A Sabatino, Kelsey F Sugrue, Irene E Zohn
INTRODUCTION: The labyrinthine zone of the placenta is where exchange of nutrients and waste occurs between maternal and fetal circulations. Proper development of the placental labyrinth is essential for successful growth of the developing fetus and abnormalities in placental development are associated with intrauterine growth restriction (IUGR), preeclampsia and fetal demise. Our previous studies demonstrate that Hectd1 is essential for development of the junctional and labyrinthine zones of the placenta...
February 2016: Placenta
https://www.readbyqxmd.com/read/26836061/dlx3-negatively-regulates-osteoclastic-differentiation-through-microrna-124
#10
Na Zhao, Dong Han, Yang Liu, Yue Li, Li Zeng, Yixiang Wang, Hailan Feng
Homeodomain gene Distal-less-3 (DLX3) plays an essential role in the development of bones. Mutations of DLX3 are closely associated with Tricho-Dento-Osseous (TDO) syndrome featured with increased bone formation. However, the mechanism regarding whether DLX3 regulates osteoclastogenesis remains largely unknown. In this study, we firstly examined the expression of DLX3 mounting during osteoclastic differentiation process, and then established stably expressing wild type DLX3 (WT-DLX3), a novel mutant DLX3 (Q178R) found in our laboratory recently (MT-DLX3) and Dlx3 knockdown cell lines (Dlx3-shRNA) in Raw 264...
February 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/26774799/osteogenic-potential-of-human-adipose-tissue-derived-mesenchymal-stromal-cells-cultured-on-3d-printed-porous-structured-titanium
#11
Eric A Lewallen, Dakota L Jones, Amel Dudakovic, Roman Thaler, Christopher R Paradise, Hilal M Kremers, Matthew P Abdel, Sanjeev Kakar, Allan B Dietz, Robert C Cohen, David G Lewallen, Andre J van Wijnen
Integration of porous metal prosthetics, which restore form and function of irreversibly damaged joints, into remaining healthy bone is critical for implant success. We investigated the biological properties of adipose-tissue-derived mesenchymal stromal/stem cells (AMSCs) and addressed their potential to alter the in vitro microenvironment of implants. We employed human AMSCs as a practical source for musculoskeletal applications because these cells can be obtained in large quantities, are multipotent, and have trophic paracrine functions...
May 1, 2016: Gene
https://www.readbyqxmd.com/read/26762616/unexpected-identification-of-a-recurrent-mutation-in-the-dlx3-gene-causing-amelogenesis-imperfecta
#12
Y-J Kim, F Seymen, M Koruyucu, Y Kasimoglu, K Gencay, T J Shin, H-K Hyun, Z H Lee, J-W Kim
OBJECTIVE: To identify the molecular genetic aetiology of a family with autosomal dominant amelogenesis imperfecta (AI). SUBJECTS AND METHODS: DNA samples were collected from a six-generation family, and the candidate gene approach was used to screen for the enamelin (ENAM) gene. Whole-exome sequencing and linkage analysis with SNP array data identified linked regions, and candidate gene screening was performed. RESULTS: Mutational analysis revealed a mutation (c...
May 2016: Oral Diseases
https://www.readbyqxmd.com/read/26674964/estrogen-receptor-%C3%AE-regulates-dlx3-mediated-osteoblast-differentiation
#13
Sung Ho Lee, Kyo-Nyeo Oh, Younho Han, You Hee Choi, Kwang-Youl Lee
Estrogen receptor α (ER-α), which is involved in bone metabolism and breast cancer, has been shown to have transcriptional targets. Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation. Various osteogenic stimulators and transcription factors can induce the protein expression of Dlx3. However, the regulatory function of ER-α in the Dlx3 mediated osteogenic process remains unknown. Therefore, we investigated the regulation of Dlx3 and found that ER-α is a positive regulator of Dlx3 transcription in BMP2-induced osteoblast differentiation...
February 2016: Molecules and Cells
https://www.readbyqxmd.com/read/26598618/histone-demethylase-kdm4b-regulates-otic-vesicle-invagination-via-epigenetic-control-of-dlx3-expression
#14
Rosa A Uribe, Ailín L Buzzi, Marianne E Bronner, Pablo H Strobl-Mazzulla
In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages of chick inner ear formation. A loss of KDM4B results in defective invagination and striking morphological changes in the otic epithelium, characterized by abnormal localization of adhesion and cytoskeletal molecules and reduced expression of several inner ear markers, including Dlx3. In vivo chromatin immunoprecipitation reveals direct and dynamic occupancy of KDM4B and its target, H3K9me3, at regulatory regions of the Dlx3 locus...
November 23, 2015: Journal of Cell Biology
https://www.readbyqxmd.com/read/26550823/dna-dependent-formation-of-transcription-factor-pairs-alters-their-binding-specificity
#15
Arttu Jolma, Yimeng Yin, Kazuhiro R Nitta, Kashyap Dave, Alexander Popov, Minna Taipale, Martin Enge, Teemu Kivioja, Ekaterina Morgunova, Jussi Taipale
Gene expression is regulated by transcription factors (TFs), proteins that recognize short DNA sequence motifs. Such sequences are very common in the human genome, and an important determinant of the specificity of gene expression is the cooperative binding of multiple TFs to closely located motifs. However, interactions between DNA-bound TFs have not been systematically characterized. To identify TF pairs that bind cooperatively to DNA, and to characterize their spacing and orientation preferences, we have performed consecutive affinity-purification systematic evolution of ligands by exponential enrichment (CAP-SELEX) analysis of 9,400 TF-TF-DNA interactions...
November 19, 2015: Nature
https://www.readbyqxmd.com/read/26522723/the-homeoprotein-dlx3-and-tumor-suppressor-p53-co-regulate-cell-cycle-progression-and-squamous-tumor-growth
#16
E Palazzo, M Kellett, C Cataisson, A Gormley, P W Bible, V Pietroni, N Radoja, J Hwang, M Blumenberg, S H Yuspa, M I Morasso
Epidermal homeostasis depends on the coordinated control of keratinocyte cell cycle. Differentiation and the alteration of this balance can result in neoplastic development. Here we report on a novel DLX3-dependent network that constrains epidermal hyperplasia and squamous tumorigenesis. By integrating genetic and transcriptomic approaches, we demonstrate that DLX3 operates through a p53-regulated network. DLX3 and p53 physically interact on the p21 promoter to enhance p21 expression. Elevating DLX3 in keratinocytes produces a G1-S blockade associated with p53 signature transcriptional profiles...
June 16, 2016: Oncogene
https://www.readbyqxmd.com/read/26478226/osteogenesis-imperfecta-type-i-caused-by-col1a1-deletions
#17
Ghalib Bardai, Emmanuelle Lemyre, Pierre Moffatt, Telma Palomo, Francis H Glorieux, Joanna Tung, Leanne Ward, Frank Rauch
Osteogenesis imperfecta (OI) type I is usually caused by COL1A1 stop or frameshift mutations, leading to COL1A1 haploinsufficiency. Here we report on 12 individuals from 5 families who had OI type I due to an unusual cause—heterozygous deletions of the entire COL1A1 gene. The deletions were initially detected by semiconductor-based sequencing of genomic DNA and confirmed by quantitative PCR. Array comparative genomic hybridization in DNA of the index patient in each family showed that deletion size varied from 18...
January 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/26332462/functional-characterization-of-a-single-nucleotide-polymorphism-in-the-3-untranslated-region-of-sheep-dlx3-gene
#18
Enguang Rong, Zhiwei Zhang, Shupei Qiao, Hua Yang, Xiaohong Yan, Hui Li, Ning Wang
The Distal-less 3 (homeobox protein DLX-3), a transcription factor, is critical for the development of hair follicle and hair formation and regeneration. We previously identified and found that four SNPs (c. *118T>C, c. *228T>C, c. *688A>G and c. *1,038_1,039 insC) in 3' untranslated region (UTR) of sheep DLX3 were in high linkage disequilibrium with each other and significantly associated with wool crimp (P<0.05), however, the underlying mechanisms by which these SNPs affect the wool crimp remains unknown...
2015: PloS One
https://www.readbyqxmd.com/read/26124283/microrna-665-regulates-dentinogenesis-through-microrna-mediated-silencing-and-epigenetic-mechanisms
#19
Hannah M Heair, Austin G Kemper, Bhaskar Roy, Helena B Lopes, Harunur Rashid, John C Clarke, Lubana K Afreen, Emanuela P Ferraz, Eddy Kim, Amjad Javed, Marcio M Beloti, Mary MacDougall, Mohammad Q Hassan
Studies of proteins involved in microRNA (miRNA) processing, maturation, and silencing have indicated the importance of miRNAs in skeletogenesis, but the specific miRNAs involved in this process are incompletely defined. Here, we identified miRNA 665 (miR-665) as a potential repressor of odontoblast maturation. Studies with cultured cell lines and primary embryonic cells showed that miR-665 represses the expression of early and late odontoblast marker genes and stage-specific proteases involved in dentin maturation...
September 2015: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26104267/morphological-analyses-and-a-novel-de-novo-dlx3-mutation-associated-with-tricho-dento-osseous-syndrome-in-a-chinese-family
#20
Yue Li, Dong Han, Hao Zhang, Haochen Liu, Singwai Wong, Na Zhao, Lixin Qiu, Hailan Feng
Tricho-dento-osseous (TDO) syndrome, an autosomal-dominant disorder, affects the morphological appearance of the tooth enamel, hair, and bone. Previous studies have confirmed that mutations in the DLX3 gene are responsible for TDO. In this study, we describe a Chinese patient with the typical traits of TDO - kinky hair, enamel hypoplasia, skull and jaw bones thickening, and sclerosis. Unfortunately, as a result of excessive attrition, we were unable to assess taurodontism. Examination of the tooth ground section showed a thin layer of enamel with no rods on the patient's tooth and abnormalities in Tomes' granular layer and the dentinal tubules...
August 2015: European Journal of Oral Sciences
keyword
keyword
5548
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"