Angkana T Huang, Henrik Salje, Ana Coello Escoto, Nayeem Chowdhury, Christian Chávez, Bernardo Garcia-Carreras, Wiriya Rutvisuttinunt, Irina Maljkovic Berry, Gregory D Gromowski, Lin Wang, Chonticha Klungthong, Butsaya Thaisomboonsuk, Ananda Nisalak, Luke M Trimmer-Smith, Isabel Rodriguez-Barraquer, Damon W Ellison, Anthony R Jones, Stefan Fernandez, Stephen J Thomas, Derek J Smith, Richard Jarman, Stephen S Whitehead, Derek A T Cummings, Leah C Katzelnick
Neutralizing antibodies are important correlates of protection against dengue. Yet, determinants of variation in neutralization across strains within the four dengue virus serotypes (DENV1-4) is imperfectly understood. Studies focus on structural DENV proteins, especially the envelope (E), the primary target of anti-DENV antibodies. Although changes in immune recognition (antigenicity) are often attributed to variation in epitope residues, viral processes influencing conformation and epitope accessibility also affect neutralizability, suggesting possible modulating roles of nonstructural proteins...
May 2022: PLoS Pathogens