Wesley H Self, Christopher S Evans, Cathy A Jenkins, Ryan M Brown, Jonathan D Casey, Sean P Collins, Taylor D Coston, Matthew Felbinger, Lisa N Flemmons, Susan M Hellervik, Christopher J Lindsell, Dandan Liu, Nicole S McCoin, Kevin D Niswender, Corey M Slovis, Joanna L Stollings, Li Wang, Todd W Rice, Matthew W Semler
IMPORTANCE: Saline (0.9% sodium chloride), the fluid most commonly used to treat diabetic ketoacidosis (DKA), can cause hyperchloremic metabolic acidosis. Balanced crystalloids, an alternative class of fluids for volume expansion, do not cause acidosis and, therefore, may lead to faster resolution of DKA than saline. OBJECTIVE: To compare the clinical effects of balanced crystalloids with the clinical effects of saline for the acute treatment of adults with DKA...
November 2, 2020: JAMA Network Open