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Occupational asthma

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https://www.readbyqxmd.com/read/28317175/occupational-respiratory-allergy-in-peach-crop-workers
#1
Remedios Pérez-Calderón, M Ángeles Gonzalo-Garijo, Francisco José Rodríguez-Velasco, Silvia Sánchez-Vega, Borja Bartolomé-Zavala
BACKGROUND: Occupational respiratory diseases in workers of peach tree crops have been reported punctually and have been associated with sensitization to proteins present in both pollen and leaf tree. We report the study of 37 workers with respiratory symptoms related to occupational exposure to peach trees. METHODS: Prick tests and specific IgE determinations were performed with extracts from leaves and branches of peach tree. Immunodetection in leaf extract was realized by SDS-PAGE-immunoblotting with patient sera and rabbit serum anti-Pru p 3...
March 20, 2017: Allergy
https://www.readbyqxmd.com/read/28314756/predicting-occupational-asthma-and-rhinitis-in-bakery-workers-referred-for-clinical-evaluation
#2
Badri Sadat Jonaid, Jos Rooyackers, Erik Stigter, Lützen Portengen, Esmeralda Krop, Dick Heederik
BACKGROUND: Occupational allergic diseases are a major problem in some workplaces like in the baking industry. Diagnostic rules have been used in surveillance but not yet in the occupational respiratory clinic. OBJECTIVE: To develop diagnostic models predicting baker's asthma and rhinitis among bakery workers at high risk of sensitisation to bakery allergens referred to a specialised clinic. METHODS: As part of a medical surveillance programme, clinical evaluation was performed on 436 referred Dutch bakery workers at high risk for sensitisation to bakery allergens...
March 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28299723/mold-and-human-health-a-reality-check
#3
REVIEW
Andrea T Borchers, Christopher Chang, M Eric Gershwin
There are possibly millions of mold species on earth. The vast majority of these mold spores live in harmony with humans, rarely causing disease. The rare species that does cause disease does so by triggering allergies or asthma, or may be involved in hypersensitivity diseases such as allergic bronchopulmonary aspergillosis or allergic fungal sinusitis. Other hypersensitivity diseases include those related to occupational or domiciliary exposures to certain mold species, as in the case of Pigeon Breeder's disease, Farmer's lung, or humidifier fever...
March 16, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28286155/diagnostic-accuracy-of-inflammatory-markers-for-diagnosing-occupational-asthma
#4
Geneviève Racine, Roberto Castano, André Cartier, Catherine Lemiere
BACKGROUND: The assessment of airway responsiveness and inflammation is key to the investigation of occupational asthma (OA). OBJECTIVE: We sought to assess and compare the diagnostic accuracies of the blood and sputum eosinophil counts and the methacholine challenge for the diagnosis of OA. METHODS: We conducted a retrospective study assessing 618 patients who underwent specific inhalation challenges (SICs) for symptoms suggestive of OA between 2000 and 2015...
March 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28276782/respiratory-symptoms-and-lung-function-in-relation-to-wood-dust-and-monoterpene-exposure-in-the-wood-pellet-industry
#5
Håkan Löfstedt, Katja Hagström, Ing-Liss Bryngelsson, Mats Holmström, Anna Rask-Andersen
INTRODUCTION: Wood pellets are used as a source of renewable energy for heating purposes. Common exposures are wood dust and monoterpenes, which are known to be hazardous for the airways. The purpose of this study was to study the effect of occupational exposure on respiratory health in wood pellet workers. MATERIALS AND METHODS: Thirty-nine men working with wood pellet production at six plants were investigated with a questionnaire, medical examination, allergy screening, spirometry, and nasal peak expiratory flow (nasal PEF)...
March 1, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28274809/behaviour-of-chemical-respiratory-allergens-in-novel-predictive-methods-for-skin-sensitisation
#6
David Basketter, Alan Poole, Ian Kimber
Asthma resulting from sensitisation of the respiratory tract to chemicals is an important occupational health issue, presenting many toxicological challenges. Most importantly there are no recognised predictive methods for respiratory allergens. Nevertheless, it has been found that all known chemical respiratory allergens elicit positive responses in assays for skin sensitising chemicals. Thus, chemicals failing to induce a positive response in skin sensitisation assays such as the local lymph node assay (LLNA) lack not only skin sensitising activity, but also the potential to cause respiratory sensitisation...
March 6, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28270447/specific-inhalation-challenge-the-relationship-between-response-clinical-variables-and-lung-function
#7
Chunshao Hu, Maria-Jesus Cruz, Iñigo Ojanguren, Miquel de Homdedeu, Francisco-Javier Gonzalez-Barcala, Xavier Munoz
INTRODUCTION: The specific inhalation challenge (SIC) is considered the gold standard for the diagnosis of occupational asthma (OA). However, its use is not standardised, and the intensity of exposure is regulated empirically. The aim of this study was to identify clinical variables and/or pulmonary function variables able to predict the scale of patients' response to SIC. MATERIAL AND METHODS: All patients who underwent SIC at our centre between 2005 and 2013 were studied...
March 7, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28268255/association-of-migraine-with-asthma-risk-a-retrospective-population-based-cohort-study
#8
Yi-Hao Peng, Kuan-Fei Chen, Wei-Chih Liao, Te-Chun Hsia, Hsuan-Ju Chen, Ming-Chien Yin, Wen-Chao Ho
BACKGROUND: Both migraine and asthma are common health problems in the general population. However, the association between these two disorders is yet to be fully explored. OBJECTIVE: We examined whether adult patients with migraine are at a higher risk of asthma development. METHODS: We used data retrieved from the National Health Insurance Research Database in Taiwan to conduct this nationwide population-based cohort study. We identified 6647 patients aged 20-60 years who were newly diagnosed with migraine between 2000 and 2005 for the migraine group and identified 26 588 patients without migraine for the nonmigraine group...
March 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28255167/toluene-diisocyanate-exposure-induces-airway-inflammation-of-bronchial-epithelial-cells-via-the-activation-of-transient-receptor-potential-melastatin-8
#9
Joo-Hee Kim, Young-Sook Jang, Seung-Hun Jang, Ki-Suck Jung, Seung-Hyun Kim, Young-Min Ye, Hae-Sim Park
Toluene diisocyanate (TDI) is the most important cause of occupational asthma (OA), and various pathogenic mechanisms have been suggested. Of these mechanisms, neurogenic inflammation is an important inducer of airway inflammation. Transient receptor potential melastatin 8 (TRPM8) is a well-established cold-sensing cation channel that is expressed in both neuronal cells and bronchial epithelial cells. A recent genome-wide association study of TDI-exposed workers found a significant association between the phenotype of TDI-induced OA and the single-nucleotide polymorphism rs10803666, which has been mapped to the TRPM8 gene...
March 3, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28240734/occupational-asthma-due-to-chamomile-case-report
#10
Silvano Cerri, Ferruccio Bernabeo, Eleonora Valsecchi, Giovanni Chiappino
We report the case of a worker employed in the packaging of herb infusions who came to our attention because he was suffering from breathing disorders caused by occupational exposure to chamomile dusts. The diagnostic procedure we followed highlighted a baseline lung function within the normal range, while the skin prick tests and the RAST test were positive to both seasonal aeroallergens and chamomile. To perform a specific bronchial provocation test, the patient was challenged in an exposure chamber with nebulization of an extract from chamomile flowers...
February 15, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28214136/japanese-guidelines-for-occupational-allergic-diseases-2017
#11
REVIEW
Kunio Dobashi, Kazuo Akiyama, Atsushi Usami, Hiroo Yokozeki, Zenro Ikezawa, Naomi Tsurikisawa, Yoichi Nakamura, Kazuhiro Sato, Jiro Okumura, Kaoru Takayama
In 2013, a guideline for occupational allergic diseases was published for the first time in Japan. Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative antigens, and are socioeconomically important diseases with which the patients might sometimes lose jobs due to work interruptions. Guidelines for occupational allergic diseases have been published in many countries. This guideline consists of six chapters about occupational asthma, occupational allergic rhinitis, occupational skin diseases, hypersensitivity pneumonitis and occupational anaphylaxis shock, and legal aspects of these diseases...
February 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28211347/occupational-asthma-to-detergent-protease-associated-with-a-late-phase-neutrophilic-cutaneous-response
#12
M Poussel, E Penven, L A Essari, F Chabot, A Barbaud, C Paris
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28177949/progress-with-structure-activity-relationship-modelling-of-occupational-chemical-respiratory-sensitizers
#13
Martin J Seed, Raymond M Agius
PURPOSE OF REVIEW: This appraises currently available computer-based ('in silico') models relating the molecular structure of low molecular weight compounds to their respiratory sensitization hazard. The present review places focus on the two main applications of such structure--activity relationship (SAR) models: hypotheses on disease mechanisms and toxicological prediction. RECENT FINDINGS: Analyses of the chemical structures of low molecular weight organic compounds known to have caused occupational asthma has led to the development of mechanistic alerts usually based on electrophilic reaction chemistry and protein cross-linking potential...
February 7, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28163029/airway-hyperresponsiveness-in-asthma-measurement-and-clinical-relevance
#14
REVIEW
Parameswaran Nair, James G Martin, Donald C Cockcroft, Myrna Dolovich, Catherine Lemiere, Louis-Philippe Boulet, Paul M O'Byrne
Airway hyperresponsiveness is a characteristic feature of asthma, and its measurement is an important tool in its diagnosis. With a few caveats, methacholine bronchial provocation by a 2-minute tidal breathing method is highly sensitive; a negative test result (PC20 > 16 mg/mL, PD20 > 400 μg) rules out current asthma with reasonable certainty. A PC20 value of less than 1 mg/mL/PD20 value of less than 25 μg is highly specific (ie, diagnostic) but quite insensitive for asthma. For accurate interpretation of the test results, it is important to control and standardize technical factors that have an impact on nebulizer performance...
February 2, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28159057/the-impact-of-parity-and-age-at-first-and-last-childbirth-on-the-prevalence-of-delayed-onset-asthma-in-women-the-korean-national-health-and-nutrition-examination-survey
#15
Ji Ho Choi, Bora Lee, Kyung Do Han, Se Hwan Hwang, Jae Hoon Cho
OBJECT: Asthma is a chronic inflammatory airway disease. The aim of this study was to investigate the relationships between asthma and reproductive factors, including age at first childbirth and parity, in a representative sample of Korean women. MAIN OUTCOME MEASURES: We analyzed data from the Korean National Health and Nutrition Examination Survey (2010-2012). A total of 7837 adults who completed a questionnaire and examination were evaluated. The presence of asthma was based on the Health Interview Survey...
March 2017: Maturitas
https://www.readbyqxmd.com/read/28153749/energy-landscape-of-a-gstp1-polymorph-linked-with-cytological-function-decay-in-response-to-chemical-stressors
#16
Zarrin Basharat, Azra Yasmin
Gene polymorphisms lead to varied structure and functional properties. A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases. Apart from this, cancer, neuropathy, NOx, SOx and ozone mediated respiratory function decline including lung inflammation, asthma, allergy etc., have been reported in people with this missense mutation. Here, the functional properties of rs1695 polymorph are revisited through a computational approach...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/28141626/update-on-asthma-and-cleaning-agents
#17
Ilenia Folletti, Andrea Siracusa, Giulia Paolocci
PURPOSE OF REVIEW: Asthma due to cleaning products has been known for 20 years, and the interest in this topic is still large because of the number of cleaning workers with respiratory problems. In this review, we sought to highlight the most recent findings on the relationship between exposure to cleaning products and asthma and to summarize the specific literature published between 2013 and 2016. RECENT FINDINGS: Women are confirmed as most of workers exposed to cleaning products and have a higher frequency than men of work-related respiratory symptoms and diseases...
April 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28139761/genome-wide-association-study-of-polymorphisms-predisposing-to-bronchiolitis
#18
Anu Pasanen, Minna K Karjalainen, Louis Bont, Eija Piippo-Savolainen, Marja Ruotsalainen, Emma Goksör, Kuldeep Kumawat, Hennie Hodemaekers, Kirsi Nuolivirta, Tuomas Jartti, Göran Wennergren, Mikko Hallman, Mika Rämet, Matti Korppi
Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis and 778 controls...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093530/what-causes-occupational-asthma-in-cleaners
#19
Vicky C Moore, P Sherwood Burge, Alastair S Robertson, Gareth I Walters
No abstract text is available yet for this article.
January 16, 2017: Thorax
https://www.readbyqxmd.com/read/28093332/chitin-and-chitinase-role-in-pathogenicity-allergenicity-and-health
#20
REVIEW
Seema Patel, Arun Goyal
Chitin, a polysaccharide with particular abundance in fungi, nematodes and arthropods is immunogenic. It acts as a threat to other organisms, to tackle which they have been endowed with chitinase enzyme. Even if this enzyme is not present in all organisms, they possess proteins having chitin-binding domain(s) (ChtBD). Many lethal viruses like Ebola, and HCV (Hepatitis C virus) have these domains to manipulate their carriers and target organisms. In keeping with the basic rule of survival, the self-origin (own body component) chitins and chitinases are protective, but that of non-self origin (from other organisms) are detrimental to health...
April 2017: International Journal of Biological Macromolecules
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