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Occupational asthma

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https://www.readbyqxmd.com/read/29792201/cerium-dioxide-nanoparticles-exacerbate-house-dust-mite-induced-type-ii-airway-inflammation
#1
Kirsty Meldrum, Sarah B Robertson, Isabella Römer, Tim Marczylo, Lareb S N Dean, Andrew Rogers, Timothy W Gant, Rachel Smith, Terry D Tetley, Martin O Leonard
BACKGROUND: Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2 NPs) have the ability to modify disease outcome but have not been investigated for their effect on models of asthma and inflammatory lung disease. The aim of this study was to examine the impact of CeO2 NPs in a house dust mite (HDM) induced murine model of asthma. RESULTS: Repeated intranasal instillation of CeO2 NPs in the presence of HDM caused the induction of a type II inflammatory response, characterised by increased bronchoalveolar lavage eosinophils, mast cells, total plasma IgE and goblet cell metaplasia...
May 23, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29785256/job-titles-classified-into-socioeconomic-and-occupational-groups-identify-subjects-with-increased-risk-for-respiratory-symptoms-independent-of-occupational-exposure-to-vapour-gas-dust-or-fumes
#2
Christian Schyllert, Martin Andersson, Linnea Hedman, Magnus Ekström, Helena Backman, Anne Lindberg, Eva Rönmark
Objectives : To evaluate the ability of three different job title classification systems to identify subjects at risk for respiratory symptoms and asthma by also taking the effect of exposure to vapours, gas, dust, and fumes (VGDF) into account. Background : Respiratory symptoms and asthma may be caused by occupational factors. There are different ways to classify occupational exposure. In this study, self-reported occupational exposure to vapours, gas, dust and fumes was used as well as job titles classifed into occupational and socioeconomic Groups according to three different systems...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29769601/urinary-polycyclic-aromatic-hydrocarbon-metabolites-and-adult-asthma-a-case-control-study
#3
Xiji Huang, Yun Zhou, Xiuqing Cui, Xiaojie Wu, Jing Yuan, Jungang Xie, Weihong Chen
Polycyclic aromatic hydrocarbons (PAHs) exposure was reported to be associated with childhood asthma. However, the quantitative relationship between PAHs exposure and adult asthma and possible inflammatory pathways are less clear. We aimed to investigate potential associations between urinary PAHs metabolites and adult asthma. We enrolled 507 adult asthma cases and 536 matched controls. The concentrations of 12 urinary PAHs metabolites and plasma cytokines of interleukin (IL)-9 and eotaxin were measured. Potential associations between urinary PAHs metabolites and adult asthma were analyzed by logistic regression...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769295/indoor-mould-exposure-asthma-and-rhinitis-findings-from-systematic-reviews-and-recent-longitudinal-studies
#4
REVIEW
Denis Caillaud, Benedicte Leynaert, Marion Keirsbulck, Rachel Nadif
Starting from the Institute of Medicine (IOM) and World Health Organization (WHO) reports, this review provides an overview of the literature published from 2006 to 2017 on the associations between indoor mould exposure and asthma and rhinitis separately in children and adults with a focus on longitudinal epidemiological studies.A systematic search of peer-reviewed literature was performed, including systematic reviews and meta-analyses, longitudinal, incident case-control and panel studies. 61 publications were identified reporting visible mould or mould odour or quantitative assessment of culturable fungi or mould species...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29765370/pig-farmers-homes-harbor-more-diverse-airborne-bacterial-communities-than-pig-stables-or-suburban-homes
#5
Ditte V Vestergaard, Gitte J Holst, Ioannis Basinas, Grethe Elholm, Vivi Schlünssen, Allan Linneberg, Tina Šantl-Temkiv, Kai Finster, Torben Sigsgaard, Ian P G Marshall
Airborne bacterial communities are subject to conditions ill-suited to microbial activity and growth. In spite of this, air is an important transfer medium for bacteria, with the bacteria in indoor air having potentially major consequences for the health of a building's occupants. A major example is the decreased diversity and altered composition of indoor airborne microbial communities as a proposed explanation for the increasing prevalence of asthma and allergies worldwide. Previous research has shown that living on a farm confers protection against development of asthma and allergies, with airborne bacteria suggested as playing a role in this protective effect...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29762654/testing-of-disposable-protective-garments-against-isocyanate-permeation-from-spray-polyurethane-foam-insulation
#6
Michael P Mellette, Dhimiter Bello, Yalong Xue, Michael Yost, Anila Bello, Susan Woskie
Background: Diisocyanates (isocyanates), including methylene diphenyl diisocyanate (MDI), are the primary reactive components of spray polyurethane foam (SPF) insulation. They are potent immune sensitizers and a leading cause of occupational asthma. Skin exposure to isocyanates may lead to both irritant and allergic contact dermatitis and possibly contribute to systemic sensitization. More than sufficient evidence exists to justify the use of protective garments to minimize skin contact with aerosolized and raw isocyanate containing materials during SPF applications...
May 12, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29748310/do-laboratory-challenge-tests-for-occupational-asthma-represent-what-happens-in-the-workplace
#7
P Sherwood Burge, Vicky C Moore, Alastair S Robertson, Gareth I Walters
INTRODUCTION: Specific inhalation challenge (SIC) is the diagnostic reference standard for occupational asthma, however the significance of a positive test is doubtful unless it can be reproduced by usual work exposures. We have compared the timing and responses during SIC in hospital to Oasys analysis of serial PEF during usual work exposures. METHODS: All workers with a positive SIC to occupational agents between 2006 and 2015 were asked to measure PEF 2-hourly from waking to sleeping for 4 weeks during usual occupational exposures...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29729044/nasal-mucosa-and-blood-cell-transcriptome-profiles-do-not-reflect-respiratory-symptoms-associated-with-moisture-damage
#8
Joseph Ndika, Hille Suojalehto, Martin Täubel, Maili Lehto, Kirsi Karvala, Paula Pallasaho, Jukka Sund, Petri Auvinen, Kati Järvi, Juha Pekkanen, Pia Kinaret, Dario Greco, Anne Hyvärinen, Harri Alenius
Upper and lower respiratory symptoms and asthma are adverse health effects associated with moisture-damaged buildings. Quantitative measures to detect adverse health effects related to exposure to dampness and mold are needed. Here, we investigate differences in gene expression between occupants of moisture-damaged and reference buildings. Moisture-damaged (N=11) and control (N=5) buildings were evaluated for dampness and mold by trained inspectors. The transcriptomics cohort consisted of nasal brushings and peripheral blood mononuclear cells (PBMCs) from 86 teachers, with/without self-perceived respiratory symptoms...
May 4, 2018: Indoor Air
https://www.readbyqxmd.com/read/29720562/airway-responsiveness-to-methacholine-and-incidence-of-copd-an-international-prospective-cohort-study
#9
Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. METHODS: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults)...
May 2, 2018: Thorax
https://www.readbyqxmd.com/read/29717106/role-of-clusterin-progranulin-in-toluene-diisocyanate-induced-occupational-asthma
#10
Gil-Soon Choi, Hoang Kim Tu Trinh, Eun-Mi Yang, Young-Min Ye, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park
Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs)...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29716705/evaluation-for-airway-obstruction-in-adult-patients-with-stable-ischemic-heart-disease
#11
M Mahendra, Sunil Kumar S, Nagaraj Desai, Jayaraj Bs, Mahesh Pa
BACKGROUND: Ischemic heart disease (IHD) and chronic airway disease (COPD and Asthma) are major epidemics accounting for significant mortality and morbidity. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. There is a need for airway evaluation in these patients to plan appropriate management. METHODS: Consecutive stable IHD patients attending the cardiology OPD in a tertiary care centre were interviewed for collecting basic demographic information, brief medical, occupational, personal history and risk factors for coronary artery disease and airway disease, modified medical research centre (MMRC) grade for dyspnea, quality of life-St...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29708861/occupational-exposures-of-flour-dust-and-airborne-chemicals-at-bakeries-in-taiwan
#12
Pei-Ting Chang, Po-Chen Hung, Shih-Wei Tsai
Walk-through surveys were carried out for bakeries in this study to determine the environmental characteristics of bakeries in Taiwan. Questionnaires were administrated to discover whether job-related asthma-like symptoms occurred among workers. Air sampling and analysis were also performed. The results show that the levels of inhalable flour dust ranged from 0.01 to 0.83 mg m-3 with an average of 0.27 mg m-3 . Among the samples collected, 23% of them had concentrations higher than the ACGIH TLV-TWA (0.5 mg m-3 ), which indicated that inhalable flour dust was an important air pollutant for bakery workers in Taiwan...
April 30, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29692816/the-course-of-asthma-during-pregnancy-in-a-recent-multicase-control-study-on-respiratory-health
#13
A Grosso, F Locatelli, E Gini, F Albicini, C Tirelli, I Cerveri, A G Corsico
Background: Over the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and the meta-analytic reviews include old studies. This study aimed to examine whether the prevalence of worsening asthma during pregnancy is still consistent with prior estimate or it has been reduced. Methods: A detailed Clinical Questionnaire on respiratory symptoms, medical history, medication, use of services, occupation, social status, home environment and lifestyle was administered to random samples of the Italian population in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29683210/measured-moisture-in-buildings-and-adverse-health-effects-a-review
#14
REVIEW
Mark J Mendell, Janet M Macher, Kazukiyo Kumagai
It has not yet been possible to quantify dose-related health risks attributable to indoor dampness or mold (D/M), to support the setting of health-related limits for D/M. An overlooked target for assessing D/M is moisture in building materials, the critical factor allowing microbial growth. A search for studies of quantified building moisture and occupant health effects identified three eligible studies. Two studies assessed associations between measured wall moisture content and respiratory health in the UK...
April 23, 2018: Indoor Air
https://www.readbyqxmd.com/read/29678453/latex-glove-use-among-healthcare-workers-in-australia
#15
Renee N Carey, Lin Fritschi, Timothy R Driscoll, Michael J Abramson, Deborah C Glass, Ellie Darcey, Si Si, Geza Benke, Alison Reid, Sonia El-Zaemey
BACKGROUND: Exposure to natural rubber latex, primarily through the use of gloves, is a well-recognized cause of occupational asthma. We investigated latex glove use among Australian workers and estimated the resultant burden of occupational asthma among healthcare workers (HCWs). METHODS: Data were collected in 2014 as part of the Australian Work Exposures Study-Asthma, a telephone survey investigating the prevalence of current occupational exposure to asthmagens, including latex...
April 17, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29676630/international-approach-to-environmental-and-lung-health-a-perspective-from-the-fogarty-international-center
#16
Roger I Glass, Joshua P Rosenthal
The global burden of lung disease is substantial, accounting for an estimated 7.5 million deaths per year, approximately 14% of annual deaths worldwide. The prime illnesses include, in descending order, chronic obstructive pulmonary disease, lung cancer, tuberculosis, acute respiratory infections, asthma, and interstitial lung fibrosis. Key risk factors include smoking, both indoor and outdoor air pollution, and occupational exposures. Although the distribution of both the diseases and the risk factors varies greatly by age, geography, and setting, the greatest burden falls on populations living in low- and middle-income countries...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29650699/update-of-an-occupational-asthma-specific-job-exposure-matrix-to-assess-exposure-to-30-specific-agents
#17
Nicole Le Moual, Jan-Paul Zock, Orianne Dumas, Theodore Lytras, Eva Andersson, Linnéa Lillienberg, Vivi Schlünssen, Geza Benke, Hans Kromhout
OBJECTIVES: We aimed to update an asthmagen job exposure matrix (JEM) developed in the late 1990s. Main reasons were: the number of suspected and recognised asthmagens has since tripled; understanding of the aetiological role of irritants in asthma and methodological insights in application of JEMs have emerged in the period. METHODS: For each agent of the new occupational asthma-specific JEM (OAsJEM), a working group of three experts out of eight evaluated exposure for each International Standard Classification of Occupations, 1988 (ISCO-88) job code into three categories: 'high' (high probability of exposure and moderate-to-high intensity), 'medium' (low-to-moderate probability or low intensity) and 'unexposed'...
April 12, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29650229/allergen-component-analysis-as-a-tool-in-the-diagnosis-and-management-of-occupational-allergy
#18
Monika Raulf
We are now in the epoch of "molecular allergology" and numerous clinically relevant allergenic molecules are available improving the performance of in vitro allergen tests and allergen detection methods. This review is focusing on characterized occupational allergens and their implementation into the in vitro diagnosis for occupational allergy and in allergen detection methods. More than 400 occupational agents are identified and documented as being 'respiratory sensitizers', but currently only a limited number of them are characterized on the molecular level and available for routine diagnosis as native or recombinant allergens...
April 9, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29626636/occupational-exposures-and-asthma-prevalence-among-us-farmworkers-national-agricultural-workers-survey-2003-2014
#19
Anna J Chen Arroyo, Lacey B Robinson, N Lance Downing, Carlos A Camargo
No abstract text is available yet for this article.
April 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29621434/isocyanates-in-australia-current-exposure-to-an-old-hazard
#20
Sonia El Zaemey, Deborah Glass, Lin Fritschi, Ellie Darcey, Renee Carey, Tim Driscoll, Michael Abramson, Si Si, Geza Benke, Alison Reid
Exposure to isocyanates has consistently been reported as the most common cause of occupational asthma. The objectives of this study were to assess how many Australian workers are currently exposed to isocyanates, identify the occupations with highest proportion of exposed workers and identify the main circumstances of exposures. Data comes from the Australian Workplace Exposure Study-Asthma, a national telephone survey which explored the prevalence of current occupational exposure to 227 asthmagens, grouped into 27 groups, among current Australian workers aged 18-65 years...
April 5, 2018: Journal of Occupational and Environmental Hygiene
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