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Occupational asthma

Rolf Merget, Ngoc Pham, Maike Schmidtke, Swaantje Casjens, Vera van Kampen, Ingrid Sander, Olaf Hagemeyer, Kirsten Sucker, Monika Raulf, Thomas Brüning
PURPOSE: Medical surveillance of workers in precious metals refineries and catalyst production plants is well established in many countries as a measure to prevent occupational asthma due to platinum (Pt) salts. It was the aim of this study to evaluate the impact of medical surveillance and to define prognostic factors with an emphasis on exposure determinants. METHODS: As part of an observational longitudinal study, 96 workers from German precious metals refineries and catalyst production plants with Pt salt allergy underwent a second examination several years (median 67 months) after the initial diagnosis was made...
October 12, 2016: International Archives of Occupational and Environmental Health
Sara Mostafalou, Mohammad Abdollahi
Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. Regardless of acute poisonings which are common for some classes of pesticides like organophosphoruses, the association of chronic and sub-lethal exposure to pesticides with a prevalence of some persistent diseases is going to be a phenomenon to which global attention has been attracted. In this review, incidence of various malignant, neurodegenerative, respiratory, reproductive, developmental, and metabolic diseases in relation to different routes of human exposure to pesticides such as occupational, environmental, residential, parental, maternal, and paternal has been systematically criticized in different categories of pesticide toxicities like carcinogenicity, neurotoxicity, pulmonotoxicity, reproductive toxicity, developmental toxicity, and metabolic toxicity...
October 8, 2016: Archives of Toxicology
Deepak Bhandari, John Russell Erskine Ruhl, Anthony John Murphy, Ernest McGahee, David Michael Chambers, Benjamin C Blount
Urinary diamines are biomarkers of diisocyanate exposure. Diisocyanates are considered as skin and respiratory sensitizers and are the most frequently reported cause of occupational asthma. Herein, we report on the development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the measurement of five aromatic diamines, 4,4'-methylenedianiline (MDA), 2,4-toluenediamine (4TDA), 2,6-toluenediamine (6TDA), 1,5-naphthalenediamine (NDA), and p-phenylenediamine (PPDA) in human urine...
October 1, 2016: Analytical Chemistry
David Lucas, Brice Lodde, Jørgen Riis Jepsen, Jean-Dominique Dewitte, Dominique Jegaden
In 2006 we published our first review based on the available literature on occupational asthma in maritime environments in the "International Maritime Health" journal. Since then, we have obtained a great deal of new knowledge on asthma in seafood workers and fishermen and on the impact of exposures from sulphites preservatives, container fumigants etc. in maritime workers. This review aims to provide an update of the current knowledge base about occupational asthma in a maritime context and to provide recommendations regarding medical surveillance of workers at risk...
2016: International Maritime Health
Gabriele Sabbioni, Lakshiminiranjan Reddy Vanimireddy, Zana L Lummus, David I Bernstein
Lung sensitization and asthma are the main health effects of 4,4'-methylenediphenyl diisocyanate (MDI). Albumin adducts (isocyanate-specific adducts) of MDI might be involved in the etiology of sensitization reactions. Albumin adducts of MDI were analyzed in sera of diisocyanate-exposed worker with and without diisocyanate occupational asthma (DA), as well as in exposed workers with and without diisocyanate-specific IgG antibodies. In DA-positive workers and IgG-positive workers, albumin adducts were significantly higher versus workers without DA and those who were specific IgG negative...
September 16, 2016: Archives of Toxicology
Chung-Lin Hung, Po-Lan Su, Chih-Ying Ou
Occupational lung diseases are well recognized risk factors for tuberculosis (TB). However, little research investigated the effect of TB on the clinical course and outcome of occupational lung diseases.We conducted a 13-year observational study of a nationwide cohort to evaluate the risk and prognosis of TB among patients with occupational lung diseases in Taiwan.By using the Taiwan National Health Insurance database, occupational lung diseases cohort was identified according to diagnosis codes from 1998 to 2008 and prospectively monitored until the end of 2010, loss to follow-up, or death...
September 2016: Medicine (Baltimore)
Antoine Vikkey Hinson, Virgil K Lokossou, Vivi Schlünssen, Gildas Agodokpessi, Torben Sigsgaard, Benjamin Fayomi
The textile industry sector occupies a prominent place in the economy of Benin. It exposes workers to several occupational risks, including exposure to cotton dust. To assess the effect of exposure to cotton dust on the health of workers, this study was initiated and conducted in a Beninese cotton industry company. The objective of the study was to evaluate the respiratory disorders among the textile workers exposed to cotton dust and the cross-sectional study involved 656 subjects exposed to cotton dust and 113 non-exposed subjects...
2016: International Journal of Environmental Research and Public Health
Rodrigo Rodriguez-Fernandez, Nawi Ng, Dwidjo Susilo, John Prawira, Michael J Bangs, Rachel M Amiya
BACKGROUND: As the global shift toward non-communicable diseases overlaps with the unfinished agenda of confronting infectious diseases in low- and middle-income countries, epidemiological links across both burdens must be recognized. This study examined the non-communicable disease-infectious disease overlap in the specific comorbidity rates for key diseases in an occupational cohort in Papua, Indonesia. METHODS: Diagnosed cases of ischaemic heart disease, stroke, hypertension, diabetes (types 1 and 2), chronic obstructive pulmonary disease, asthma, cancer, HIV and AIDS, tuberculosis, and malaria were extracted from 22,550 patient records (21,513 men, 1037 women) stored in identical electronic health information systems from two clinic sites in Papua, Indonesia...
2016: BMC Public Health
Katja Radon, Dennis Nowak, Christian Vogelberg, Franziska Ruëff
BACKGROUND: One-third of all young persons entering the work force have a history of atopic disease. Occupationally induced allergy and asthma generally arise in the first few months on the job, while pre-existing symptoms tend to worsen. Young persons with a history of an atopic disease should receive evidence-based advice before choosing a career. METHODS: We systematically searched PubMed for cohort studies investigating the new onset of asthma, rhinitis, or hand eczema among job trainees from before the start of training and onward into the first few years on the job...
August 8, 2016: Deutsches Ärzteblatt International
C Quinot, O Dumas, P K Henneberger, R Varraso, A S Wiley, F E Speizer, M Goldberg, J P Zock, C A Camargo, N Le Moual
OBJECTIVES: Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM. METHODS: Disinfectant use was assessed by an occupational questionnaire in 9073 US female registered nurses without asthma, aged 49-68 years, drawn from the Nurses' Health Study II...
August 26, 2016: Occupational and Environmental Medicine
Cecilie Svanes, Jennifer Koplin, Svein Magne Skulstad, Ane Johannessen, Randi Jakobsen Bertelsen, Byndis Benediktsdottir, Lennart Bråbäck, Anne Elie Carsin, Shyamali Dharmage, Julia Dratva, Bertil Forsberg, Thorarinn Gislason, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Rain Jögi, Susanne Krauss-Etschmann, Eva Lindberg, Ferenc Macsali, Andrei Malinovschi, Lars Modig, Dan Norbäck, Ernst Omenaas, Eirunn Waatevik Saure, Torben Sigsgaard, Trude Duelien Skorge, Øistein Svanes, Kjell Torén, Carl Torres, Vivi Schlünssen, Francisco Gomez Real
BACKGROUND: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. METHODS: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever...
August 25, 2016: International Journal of Epidemiology
(no author information available yet)
As current educational formats largely neglect occupational health, occupational health physicians could possibly be enlisted to help make TPE programmes more effective in this domain.</ce:para>.
May 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Keiko Minamoto, Takeshi Watanabe, Thomas L Diepgen
BACKGROUND: Dental workers are considered to have a high risk of developing occupational hand eczema. OBJECTIVES: To estimate the prevalence of work-related hand eczema and associated risk factors in dental workers in Japan. METHODS: A self-administered questionnaire was sent by mail to all dental clinics of Kumamoto City, Japan. In addition, patch testing with 24 dentistry-related allergens was offered. RESULTS: In total, 46...
October 2016: Contact Dermatitis
Javier Dominguez-Ortega, Pilar Barranco, Rosa Rodríguez-Pérez, Santiago Quirce
PURPOSE OF REVIEW: Work-related asthma is a common disorder among adult asthma patients, and in the case of occupational asthma, it is induced by workplace exposures. RECENT FINDINGS: Occupational asthma provides an excellent model and benchmark for identifying and testing different allergy or inflammatory biomarkers associated with its inception or progression. Moreover, specific inhalation challenge with the incriminated agent represents an experimental setting to identify and validate potential systemic or local biomarkers...
September 2016: Current Allergy and Asthma Reports
Sehrish Badar, Syed Waseemuddin Ahmed, Zafar Alam Mahmood, Sheikh Abdul Khaliq, Iqbal Azhar, Ishrat Younus
No abstract text is available yet for this article.
July 2016: Iranian Journal of Public Health
J P Zhang, D Y Sun
No abstract text is available yet for this article.
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
S S Gao, X Li
OBJECTIVE: To investigate the incidence of occupational asthma induced by occupational exposure to detergents and spices. METHODS: The occupational history, case data, and results of auxiliary examinations were collected from patients with asthma induced by occupational exposure to detergents and spices and submitted to the expert group for diagnosis of occupational diseases to obtain the diagnostic results. RESULTS: Both patients with asthma were exposed to asthmogenic substances in the working environment and developed the symptoms of asthma after a certain latency period...
April 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Majken H Foss-Skiftesvik, Lone Winther, Claus R Johnsen, Heidi Søsted, Holger F Mosbech, Claus Zachariae, Jeanne D Johansen
BACKGROUND: Little is known about the occurrence of respiratory symptoms among hairdressing apprentices during their training. Therefore, in this study, we examined whether hairdressing apprentices are at increased risk of rhinitis and asthma symptoms when compared with other young adults from the general population. METHODS: A questionnaire was completed by 504 hairdressing apprentices and 1400 control participants from the general population with a similar age, gender, and geographic distribution...
August 11, 2016: International Forum of Allergy & Rhinology
Alison B Singer, Gayle C Windham, Lisa A Croen, Julie L Daniels, Brian K Lee, Yinge Qian, Diana E Schendel, M Daniele Fallin, Igor Burstyn
Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1...
August 10, 2016: Journal of Autism and Developmental Disorders
Marta Rava, Ismail Ahmed, Manolis Kogevinas, Nicole Le Moual, Emmanuelle Bouzigon, Ivan Curjuric, Marie-Hélène Dizier, Orianne Dumas, Juan R Gonzalez, Medea Imboden, Amar J Mehta, Pascale Tubert-Bitter, Jan-Paul Zock, Deborah Jarvis, Nicole M Probst-Hensch, Florence Demenais, Rachel Nadif
BACKGROUND: The biological mechanisms by which cleaning products and disinfectants - an emerging risk factor - affect respiratory health remain incompletely evaluated. Studying genes by environment interactions (GxE) may help identify new genes related to adult-onset asthma. OBJECTIVES: To identify interactions between genetic polymorphisms of a large set of genes involved in the response to oxidative stress, and occupational exposures to low molecular weight (LMW) agents or irritants on adult-onset asthma...
August 9, 2016: Environmental Health Perspectives
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