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Occupational asthma

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https://www.readbyqxmd.com/read/28533885/-occupational-asthma-compensation-in-the-tunisian-center-cross-sectional-study-over-a-period-of-eight-years
#1
Amira Omrane, Awatef Kreim, Mohamed Adnène Henchi, Selma Kammoun, Leila Bessadi, Charfeddine Amri, Taoufik Khalfallh, Lamia Bouzgarrou
INTRODUCTION: Our study aimed to highlight the epidemiological profile of patients compensated for occupational asthma in the Tunisian Center, to identify their professional characteristics and to determine compensation practices for this occupational disease. METHODS: We conducted an exhaustive retrospective study over a period of eight years. This case study included workers with occupational asthma diagnosed and compensated in the Tunisian Center by the only two medical commissions empowered to set rates for permanent partial disability caused by either a work-related injury or an occupational diseases in the seven central governorates...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28505409/human-asthmatic-bronchial-cells-are-more-susceptible-to-sub-chronic-repeated-exposures-of-aerosolized-carbon-nanotubes-at-occupationally-relevant-doses-than-healthy-cells
#2
Savvina Chortarea, Hana Barosova, Martin James David Clift, Peter Wick, Alke Petri-Fink, Barbara Rothen-Rutishauser
Although acute pulmonary toxicity of carbon nanotubes (CNTs) has been extensively investigated, the knowledge of potential health effects following chronic occupational exposure is currently limited and based only upon in vivo approaches. Our aim was to realistically mimic sub-chronic inhalation of multi-walled CNTs (MWCNTs) in vitro, using the Air-Liquid Interface Cell Exposure system (ALICE) for aerosol exposures onto reconstituted human bronchial tissue from healthy and asthmatic donors. The reliability and sensitivity of the system was validated using crystalline quartz (DQ12), which elicited an increased (pro-)inflammatory response, as reported in vivo...
May 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28497920/prevalence-of-self-reported-allergic-diseases-and-ige-levels-a-2010-knhanes-analysis
#3
Hye Jung Park, Eun Jin Kim, Dankyu Yoon, Jeom Kyu Lee, Woo Sung Chang, Yoen Mi Lim, Jung Won Park, Joo Shil Lee
PURPOSE: The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea. METHODS: We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497854/allergic-sinusitis-and-severe-asthma-caused-by-occupational-exposure-to-locust-bean-gum-case-report
#4
Brie Hawley, Kristin J Cummings, Mohammed Mohammed, Anne E Dimmock, Rebecca Bascom
We present a case that highlights the difficulties with diagnosis and the dangers of occupational allergic sinusitis and asthma left unrecognized. We describe the case history of a man who experienced work-related symptoms 1 year after beginning work as a cheesemaker at a creamery, and whose respiratory symptoms progressively worsened over 16 years before an occupational cause of his asthma was identified. His initial discrete episodes of sinusitis and acute bronchitis evolved into persistent asthma of increasing severity with exacerbations requiring repeated emergency room treatment...
May 12, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28497800/reciprocal-regulation-of-the-il9-locus-by-counteracting-activities-of-transcription-factors-irf1-and-irf4
#5
Lucia Campos Carrascosa, Matthias Klein, Yohko Kitagawa, Christina Lückel, Federico Marini, Anika König, Anna Guralnik, Hartmann Raifer, Stefanie Hagner-Benes, Diana Rädler, Andreas Böck, Cholho Kang, Michael Lohoff, Holger Garn, Bianca Schaub, Friederike Berberich-Siebelt, Shimon Sakaguchi, Tobias Bopp, Magdalena Huber
The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependently promotes, whereas IRF1 inhibits, IL-9 production. Likewise, IRF1 inhibits IL-9 production by human Th9 cells. IRF1 counteracts IRF4-driven Il9 promoter activity, and IRF1 and IRF4 have opposing function on activating histone modifications, thus modulating RNA polymerase II recruitment...
May 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28489470/reaction-products-of-hexamethylene-diisocyanate-vapors-with-self-molecules-in-the-airways-of-rabbits-exposed-via-tracheostomy
#6
Adam V Wisnewski, Jean Kanyo, Jennifer Asher, James A Goodrich, Grace Barnett, Lyn Patrylak, Jian Liu, Carrie A Redlich, Ala F Nassar
Hexamethylene diisocyanate (HDI) is a widely used aliphatic diisocyanate and a well-recognized cause of occupational asthma. "Self" molecules (peptides/proteins) in the lower airways, susceptible to chemical reactivity with HDI, have been hypothesized to play a role in asthma pathogenesis and/or chemical metabolism, but remain poorly characterized. This study employed unique approaches to identify and characterize "self" targets of HDI reactivity in the lower airways. Anesthetized rabbits free breathed through a tracheostomy tube connected to chambers containing either, O2, or O2 plus ∼200 ppb HDI vapors...
May 10, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28483971/association-of-household-cleaning-agents-and-disinfectants-with-asthma-in-young-german-adults
#7
Tobias Weinmann, Jessica Gerlich, Sabine Heinrich, Dennis Nowak, Erika von Mutius, Christian Vogelberg, Jon Genuneit, Stefanie Lanzinger, Saba Al-Khadra, Tina Lohse, Irina Motoc, Viola Walter, Katja Radon
OBJECTIVES: We scrutinised the association of private use of household sprays and disinfectants with asthma incidence in young adults in the transition from school to working life. METHODS: Between 2007 and 2009,2051 young adults aged 19-24 years living in two major German cities took part in the Study on Occupational Allergy Risks II. Self-reported exposure to household sprays and disinfectants was characterised according to a composite score for frequency of use as no use (score=0), low use (score between 1 and the median), medium use (score between the median and the 90th percentile) and high use (score above the 90th percentile)...
May 8, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28481622/cardiomyocytes-of-the-heart-and-pulmonary-veins-novel-contributors-to-asthma
#8
Stephen Sai Folmsbee, Cara J Gottardi
Recent genome-wide association studies have implicated both cardiac and pulmonary vein-related genes in the pathogenesis of asthma. Since cardiac cells are not present in lung airways or viewed to affect the immune system, interpretation of these findings in the context of more well-established contributors to asthma has remained challenging. However, cardiomyocytes are present in the lung, specifically along pulmonary veins, and recent murine models suggest that cardiac cells lining pulmonary veins may contribute to allergic airway disease...
May 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28481378/occupational-diseases-in-the-automotive-industry-in-czechia-geographic-and-medical-context
#9
Jan Jarolímek, Pavel Urban, Petr Pavlínek, Dagmar Dzurova
OBJECTIVES: The automotive industry represents the most important industrial sector in Czechia. The objective of this study has been to analyze the occurrence of occupational diseases (OD) in the automotive industry during the period from 2001 till 2014. MATERIAL AND METHODS: Data on OD cases was retrieved from the National Registry of OD. Further, we conducted a survey in automotive companies with focus on occupational health services and positions of the companies in global production networks (GPNs)...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28463537/diagnosis-of-western-red-cedar-asthma-using-a-blood-based-gene-expression-biomarker-panel
#10
Chen Xi Yang, Amrit Singh, Young Woong Kim, Edward M Conway, Christopher Carlsten, Scott J Tebbutt
Western red cedar asthma is the most common form of occupational asthma in the Pacific Northwest region of North America and is caused by a low molecular weight molecule, plicatic acid, found in western red cedar wood. In the present study, peripheral whole blood transcriptomics was used to identify biomarker panels that distinguish asthmatic individuals who are sensitive to plicatic acid from asthmatic individuals who are not sensitive to plicatic acid. These findings suggest that blood may be used as a resource to diagnose western red cedar asthma...
May 2, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28441984/asthma-control-in-saudi-arabia-gender-implications
#11
Armen A Torchyan
BACKGROUND: Gender-related factors in asthma control should be considered in clinical consultations to substantially improve asthma control in women. Meanwhile, a limited number of studies have been reported on gender differences in factors related to asthma control, especially in Saudi Arabia. OBJECTIVE: To study the potential gender differences in factors associated with asthma control among adult patients with physician-diagnosed asthma. METHODS: A cross-sectional study was conducted in adult patients with asthma who attended primary care clinics at three major hospitals in Riyadh, Saudi Arabia...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28440535/socioeconomic-status-and-its-relationship-to-chronic-respiratory-disease
#12
Sonu Sahni, Ankoor Talwar, Sameer Khanijo, Arunabh Talwar
Socioeconomic status (SES) is defined as an individual's social or economic standing, and is a measure of an individual's or family's social or economic position or rank in a social group. It is a composite of several measures including income, education, occupation, location of residence or housing. Studies have found a lower SES has been linked to disproportionate access to health care in many diseases. There is emerging data in pulmonary diseases such as COPD, asthma, cystic fibrosis, pulmonary hypertension and other chronic respiratory conditions that allude to a similar observation noted in other chronic diseases...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28439933/effect-of-anti-ige-in-occupational-asthma-caused-by-exposure-to-low-molecular-weight-agents
#13
M Ollé-Monge, M J Cruz, S Gomez-Ollés, I Ojanguren, J Vanoirbeek, X Muñoz
BACKGROUND: The role of immunoglobulin (Ig)-E in occupational asthma (OA) due to low molecular weight (LMW) agents is not well established compared to classical atopic asthma. In the present study we evaluate whether anti-IgE monoclonal antibody (mAb) has an effect in a mouse model of OA, using persulfate salts. METHODS: On days 1 and 8, BALB/C mice were dermally sensitized with 5% ammonium persulfate (AP) or dimethyl sulfoxide (DMSO). On days 15, 18 and 21 animals were injected intraperitoneally with anti-IgE mAb or PBS 6 hours before challenge with AP or saline...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28434545/opportunities-and-obstacles-in-translating-evidence-to-policy-in-occupational-asthma
#14
Susan M Tarlo, Ahmed A Arif, George L Delclos, Paul Henneberger, Jenil Patel
PURPOSE: Occupational asthma (OA), a common respiratory disorder in Western countries, is caused by exposures at the workplace. It is part of a broader definition of work-related asthma (WRA) that also includes pre-existing asthma aggravated by substances present in the workplace environment, and it is potentially preventable. The purpose of this paper is to illustrate preventive measures for occupational asthma by case studies. METHODS: In three case studies we discuss preventive measures that have been associated with reductions in incidence of occupational asthma from natural rubber latex and from diisocyanates as supported by published literature...
March 31, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28431005/occupational-asthma-caused-by-acrylic-compounds-from-shield-surveillance-1989-2014
#15
G I Walters, A S Robertson, V C Moore, P S Burge
Background: Acrylic monomers (acrylates), methacrylates and cyanoacrylates all cause asthma by respiratory sensitization. Occupational inhalation exposures occur across a variety of industries including health care and dental work, beauty, laboratory science, assembly and plastic moulding. Aims: To examine notifications of occupational asthma caused by acrylic compounds from a UK-based regional surveillance scheme, in order to highlight prevalent exposures and trends in presentation...
April 20, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28425826/lung-function-and-prevalence-of-respiratory-symptoms-in-norwegian-crab-processing-workers
#16
Marte R Thomassen, Lisbeth Aasmoe, Berit E Bang, Tonje Braaten
BACKGROUND: Seafood processing workers have an increased risk of developing occupational asthma. This has not been studied among Norwegian crab processing workers, nor has the respiratory health of exposed workers been compared to a control group. OBJECTIVES: Assessing the impact of working in the crab processing industry on workers' respiratory health. DESIGN: A cross-sectional study of the respiratory health in two types of crab processing workers compared to a control group...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28400946/the-state-of-asthma-epidemiology-an-overview-of-systematic-reviews-and-their-quality
#17
Jon Genuneit, Annina M Seibold, Christian J Apfelbacher, George N Konstantinou, Jennifer J Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr, Michael R Perkin
BACKGROUND: Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the quality of systematic reviews in asthma using the AMSTAR checklist and to provide a reference for future, more in-depth assessment of the extent of previous knowledge. METHODS: We included all 307 systematic reviews indexed with asthma, including occupational asthma, and/or wheeze from our previous search in PubMed and EMBASE up to December 2014 for systematic reviews on epidemiological research on allergic diseases...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28383629/ip-10-in-occupational-asthma-review-of-the-literature-and-case-control-study
#18
F Ragusa, P Fallahi
OBJECTIVES: T-helper (Th)2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon (IFN)-γ-induced protein 10 (IP-10)/chemokine (C-X-C motif) ligand (CXCL)10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. Viral infection and allergens can exacerbate asthma by inducing the accumulation of these chemokines and inflammatory cells in the airway. Short-acting β2-adrenoreceptor agonists, budesonide and formoterol (all important relievers in asthma exacerbation), such as vitamin D3, vitamin C, have been shown to inhibit airway cells inflammatory responses by modulating these chemokines...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28378893/characterization-of-a-novel-allergenic-protein-from-the-octocoral-scleronephthya-gracillima-kuekenthal-that-corresponds-to-a-new-gfp-like-family-named-akane
#19
Yuko Kato, Mitsuru Jimbo, Youichi Sakakibara, Reiko Onizuka, Tatsuya Takahashi, Sachiko Matsuhashi, Hajime Mita, Kei Amada, Yukimitsu Imahara, Kimiko Tanabe, Akihisa Toda, Hisao Kamiya
Certain marine organisms have been known to cause allergic reactions among occupational fishermen. We have previously reported that bronchial asthma among the workers engaged in spiny lobster fishing in Japan was caused by octocorals such as Dendronephthya sp. and Scleronephthya gracillima (previously named Alcyonium gracillimum). Now we have found another octocoral, Scleronephthya gracillima (Kuekenthal), which causes the allergic disease in fishermen. The octocoral was characterized as a new green fluorescent protein (GFP)-like family...
April 5, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28360458/prevalence-and-etiological-profile-of-chronic-obstructive-pulmonary-disease-in-nonsmokers
#20
Tariq Mahmood, Ravindra Kumar Singh, Surya Kant, Amitabh Das Shukla, Alok Chandra, Rajneesh Kumar Srivastava
BACKGROUND: Tobacco smoking has been recognized as the most important risk factor for chronic obstructive pulmonary disease (COPD) for a long time, but recent studies have shown that nonsmokers also contribute to a significant proportion of COPD. This study was performed to find out the proportion of nonsmoker individuals among COPD patients and to determine various etiologies in nonsmoker COPD patients. MATERIALS AND METHODS: This study was an observational cross-sectional study conducted in Department of Pulmonary Medicine, MLN Medical College, Allahabad...
March 2017: Lung India: Official Organ of Indian Chest Society
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