Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A D Vo, Anja F Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristýna Barvíková, Marleen van Greevenbroek, Viktor Kožich, Kjetil Retterstøl, Kathrine J Vinknes
BACKGROUND: Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. METHODS: N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5...
January 9, 2024: Journal of Translational Medicine