keyword
MENU ▼
Read by QxMD icon Read
search

dietary leptin

keyword
https://www.readbyqxmd.com/read/29791472/pioglitazone-abolishes-autistic-like-behaviors-via-the-il-6-pathway
#1
Thiago Berti Kirsten, Renato C Casarin, Maria M Bernardi, Luciano F Felicio
Autism is characterized by social deficits, communication abnormalities, and repetitive behaviors. The risk factors appear to include genetic and environmental conditions, such as prenatal infections and maternal dietary factors. Previous investigations by our group have demonstrated that prenatal exposure to lipopolysaccharide (LPS), which mimics infections by gram-negative bacteria, induces autistic-like behaviors. No effective treatment yet exists for autism. Therefore, we used our rat model to test a possible treatment for autism...
2018: PloS One
https://www.readbyqxmd.com/read/29785132/influence-of-fto-rs9939609-polymorphism-on-appetite-ghrelin-leptin-il6-tnf%C3%AE-levels-and-food-intake-of-women-with-morbid-obesity
#2
Fernanda Cristina Carvalho Mattos Magno, Helena Chrispim Guaraná, Ana Carolina Proença Fonseca, Giselda Maria Kalil Cabello, João Régis Ivar Carneiro, Aline Pereira Pedrosa, Ana Carolina Ximenes, Eliane Lopes Rosado
Background: The fat mass and obesity-related ( FTO ) gene has a strong relationship with obesity, extreme obesity and inflammatory state, and may also be associated with food intake regulation. Objective: The aim of the present study was to evaluate the influence of the rs9939609 single-nucleotide polymorphism of the FTO gene on appetite, ghrelin, leptin, interleukin 6 (IL6), tumor necrosis factor α (TNFα) levels and food intake of morbidly obese women. Materials and methods: The study comprised 70 women, aged between 20 and 48 years, from Rio de Janeiro, Brazil...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29770757/soya-protein-%C3%AE-conglycinin-ameliorates-fatty-liver-and-obesity-in-diet-induced-obese-mice-through-the-down-regulation-of-ppar%C3%AE
#3
Dongyang Li, Reina Ikaga, Tomomi Yamazaki
Diets high in fat can result in obesity and non-alcoholic fatty liver disease (NAFLD). The improvement of obesity and NAFLD is an important issue. β-Conglycinin, one of the soya proteins, is known to prevent hyperlipidaemia, obesity and NAFLD. Therefore, we aimed to investigate the effects of β-conglycinin on the improvement of obesity and NAFLD in high-fat (HF) diet-induced obese (DIO) mice and clarify the mechanism underlying these effects in liver and white adipose tissue (WAT). DIO male ddY mice were divided into six groups: HF, medium-fat (MF) and low-fat (LF) groups fed casein, and HF, MF and LF groups in all of which the casein was replaced by β-conglycinin...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29768109/effects-of-phytosterol-supplementation-on-serum-levels-of-lipid-profiles-liver-enzymes-inflammatory-markers-adiponectin-and-leptin-in-patients-affected-by-nonalcoholic-fatty-liver-disease-a-double-blind-placebo-controlled-randomized-clinical-trial
#4
Mohammad Ali Javanmardi, Majid Mohammad Shahi, Seyed Saeed Seyedian, Mohammad Hossein Haghighizadeh
OBJECTIVE: Considering the high prevalence of nonalcoholic fatty liver disease and based on the evidence about the role of dietary cholesterol in liver inflammation, and also with regard to the effect of phytosterols on the metabolism of cholesterol, we aimed at exploring the therapeutic potential of phytosterol supplementation against nonalcoholic fatty liver disease. METHOD: Thirty-eight patients with nonalcoholic fatty liver disease were randomly divided into two groups: The phytosterol group (n = 19) received a 1...
May 16, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29762052/effects-of-physical-exercise-on-adiponectin-leptin-and-inflammatory-markers-in-childhood-obesity-systematic-review-and-meta-analysis
#5
Felice Sirico, Antonio Bianco, Giovanni D'Alicandro, Clotilde Castaldo, Stefania Montagnani, Rocco Spera, Franca Di Meglio, Daria Nurzynska
BACKGROUND: New findings on adipose tissue physiology and obesity-associated inflammation status suggest that modification of the adipokine level can be relevant for the long-term prevention of obesity-associated chronic disease. OBJECTIVES: The scope of the present study was to investigate the effectiveness of physical exercise in reducing the systemic inflammation related to obesity in children. METHODS: We conducted a systematic review with meta-analysis of controlled randomized trials, identified through electronic database search, which investigated the effect of physical exercise, without concomitant dietary intervention, on adiponectin, leptin, and/or other inflammatory markers in children up to age 18 years with a body mass index greater than the 95th percentile for age and sex...
May 15, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29746501/dietary-challenges-differentially-affect-activity-and-sleep-wake-behavior-in-mus-musculus-isolating-independent-associations-with-diet-energy-balance-and-body-weight
#6
Isaac J Perron, Brendan T Keenan, Karthikeyani Chellappa, Nicholas F Lahens, Nicole L Yohn, Keith R Shockley, Allan I Pack, Sigrid C Veasey
BACKGROUND AND AIMS: Associated with numerous metabolic and behavioral abnormalities, obesity is classified by metrics reliant on body weight (such as body mass index). However, overnutrition is the common cause of obesity, and may independently contribute to these obesity-related abnormalities. Here, we use dietary challenges to parse apart the relative influence of diet and/or energy balance from body weight on various metabolic and behavioral outcomes. MATERIALS AND METHODS: Seventy male mice (mus musculus) were subjected to the diet switch feeding paradigm, generating groups with various body weights and energetic imbalances...
2018: PloS One
https://www.readbyqxmd.com/read/29740277/hedonic-eating-and-the-delicious-circle-from-lipid-derived-mediators-to-brain-dopamine-and-back
#7
REVIEW
Roberto Coccurello, Mauro Maccarrone
Palatable food can be seductive and hedonic eating can become irresistible beyond hunger and negative consequences. This is witnessed by the subtle equilibrium between eating to provide energy intake for homeostatic functions, and reward-induced overeating. In recent years, considerable efforts have been devoted to study neural circuits, and to identify potential factors responsible for the derangement of homeostatic eating toward hedonic eating and addiction-like feeding behavior. Here, we examined recent literature on "old" and "new" players accountable for reward-induced overeating and possible liability to eating addiction...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29717885/time-restricted-feeding-of-a-high-fat-diet-in-c57bl-6-male-mice-reduces-adiposity-but-does-not-protect-against-increased-systemic-inflammation
#8
Laura B Delahaye, Richard J Bloomer, Matthew B Butawan, Jacqueline M Wyman, Jessica L Hill, Harold W Lee, Andrew C Liu, Liam McAllan, Joan C Han, Marie van der Merwe
Time-restricted feeding (TRF) limits duration of food availability without altering diet composition and can combat obesity in humans and mice. For this study we evaluated the effect of timing of food access during a TRF protocol on weight gain, adiposity and inflammation. Young C57BL/6 male mice were placed on a 45% high fat (HF) diet for 8 weeks. Food access was unrestricted (HF) or restricted to 6 hours per day, either for the first half (HF-early) or the second half (HF-late) of the active phase to resemble a window of time for food consumption early <u><i></u>vs<u></i></u> late in the day in a human population...
May 2, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29717270/biological-and-psychological-mediators-of-the-relationships-between-fat-mass-fat-free-mass-and-energy-intake
#9
Mark Hopkins, Graham Finlayson, Cristiana Duarte, Catherine Gibbons, Alexandra M Johnstone, Stephen Whybrow, Graham W Horgan, John E Blundell, R James Stubbs
BACKGROUND: While recent studies in humans indicate that fat-free mass (FFM) is closely associated with energy intake (EI) when in energy balance, associations between fat mass (FM) and EI are inconsistent. OBJECTIVES: The present study used a cross-sectional design to examine the indirect and direct effects of FFM, FM and resting metabolic rate (RMR) on EI in individuals at or close to energy balance. METHODS: Data for 242 individuals (114 males; 128 females; BMI = 25...
March 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29699923/discovery-of-dimethyl-pent-4-ynoic-acid-derivatives-as-potent-and-orally-bioavailable-dgat1-inhibitors-that-suppress-body-weight-in-diet-induced-mouse-obesity-model
#10
Tao Yu, Chengde Wu, NengYang Shih, Qi Li, Chichung Chan, He Pan, Dan Yao, Yan Pan, Wei Liang, Liang Shen, Hui Zhao, Jian Li, Shuhui Chen
Diacylglycerol acyltransferase (DGAT) is expressed abundantly in intestine, liver, and adipose tissues. DGAT1 is the crucial and rate-limiting enzyme that mediates the final step in triacylglycerol (TAG) resynthesis during dietary fat absorption. However, too much triacylglycerol (TAG) reserve will lead to genetic obesity (Hubert et al., 2000). DGAT1 knockout mice could survive and displayed a reduction in the postprandial rise of plasma TG, and increased sensitivity of insulin and leptin. Here we report the discovery and characterization of a novel selective DGAT1 inhibitor 29 to potentially treat obesity...
June 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29671182/self-reported-dietary-flavonoid-intake-and-serum-markers-of-inflammation-the-multiethnic-cohort
#11
Sabine Rohrmann, Yurii B Shvetsov, Yukiko Morimoto, Lynne R Wilkens, Kristine R Monroe, Loïc Le Marchand, Adrian A Franke, Laurence N Kolonel, Gertraud Maskarinec
PURPOSE: To examine if dietary intake of foods rich in flavonoids, which have been shown to be inversely associated with chronic diseases, is associated with inflammatory processes. METHODS: This analysis includes controls of case-control studies nested within the Multiethnic Cohort (MEC) who completed a validated food frequency questionnaire at cohort entry. Biomarkers were assessed in blood donated during follow-up (mean = 9.6 years). We used multivariate linear regression adjusted for potential confounders to estimate associations between intake of flavanones, flavonols, and isoflavones and levels of adiponectin, leptin, C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor-α...
April 18, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29599686/alignments-of-endocrine-anthropometric-and-metabolic-parameters-in-type-2-diabetes-after-intervention-with-an-okinawa-based-nordic-diet
#12
Bodil Ohlsson, Gassan Darwiche, Bodil Roth, Peter Höglund
Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes. Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29589625/long-chain-polyunsaturated-fatty-acids-and-extensively-hydrolyzed-casein-induced-browning-in-a-ucp-1-reporter-mouse-model-of-obesity
#13
Liufeng Mao, Jiwen Lei, Marieke H Schoemaker, Bingxiu Ma, Yan Zhong, Tim T Lambers, Eric A F Van Tol, Yulai Zhou, Tao Nie, Donghai Wu
Browning in adipose tissues, which can be affected by diet, may mitigate the detrimental effects of adiposity and improve longer-term metabolic health. Here, browning-inducing effects of long-chain polyunsaturated fatty acids, e.g., arachidonic acid (ARA)/docosahexaenoic acid (DHA) and extensively hydrolyzed casein (eHC) were investigated in uncoupling protein 1 (Ucp-1) reporter mice. To address the overall functionality, their potential role in supporting a healthy metabolic profile under obesogenic dietary challenges later in life was evaluated...
March 28, 2018: Food & Function
https://www.readbyqxmd.com/read/29580071/metabolic-syndrome-components-is-there-a-difference-according-to-exposure-to-night-work
#14
Narriane Chaves Pereira de Holanda, Claudia Roberta de Castro Moreno, Elaine Cristina Marqueze
The aim of this study was to compare metabolic aspects potentially associated with metabolic syndrome (MetS), in addition to serum leptin levels and sleep, according to exposure to night work among nursing staff. A cross-sectional study involving 60 nursing staff was conducted. Sociodemographic, sleep (Karolinska Sleep Questionnaire), physical activity (International Physical Activity Questionnaire), and nutrition data (16-Food Intake Questionnaire) were collected. Body measurements and blood pressure were taken and blood collected to determine glycemia, total cholesterol and portions of low-density lipoprotein and high-density lipoprotein and triglycerides, and leptin levels...
March 26, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29574638/long-chain-omega-3-polyunsaturated-fatty-acids-modulate-mammary-gland-composition-and-inflammation
#15
Saraswoti Khadge, Geoffrey M Thiele, John Graham Sharp, Timothy R McGuire, Lynell W Klassen, Paul N Black, Concetta C DiRusso, James E Talmadge
Studies in rodents have shown that dietary modifications as mammary glands (MG) develop, regulates susceptibility to mammary tumor initiation. However, the effects of dietary PUFA composition on MGs in adult life, remains poorly understood. This study investigated morphological alterations and inflammatory microenvironments in the MGs of adult mice fed isocaloric and isolipidic liquid diets with varying compositions of omega (ω)-6 and long-chain (Lc)-ω3FA that were pair-fed. Despite similar consumption levels of the diets, mice fed the ω-3 diet had significantly lower body-weight gains, and abdominal-fat and mammary fat pad (MFP) weights...
March 25, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29564847/exercise-training-at-maximal-fat-oxidation-intensity-for-older-women-with-type-2-diabetes
#16
RANDOMIZED CONTROLLED TRIAL
Sijie Tan, Ping Du, Wanting Zhao, Jiaqi Pang, Jianxiong Wang
The purpose of this study was to investigate the pleiotropic effects of 12 weeks of supervised exercise training at maximal fat oxidation (FATmax) intensity on body composition, lipid profile, glycemic control, insulin sensitivity and serum adipokine levels in older women with type 2 diabetes. Thirty-one women with type 2 diabetes, aged 60 to 69 years, were randomly allocated into exercise and control groups. Body composition, lipid profile, blood glucose, insulin resistance and serum leptin and adiponectin concentrations were measured before and after the intervention...
May 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29563885/interplay-between-peripheral-and-central-inflammation-in-autism-spectrum-disorders-possible-nutritional-and-therapeutic-strategies
#17
REVIEW
Claudia Cristiano, Adriano Lama, Francesca Lembo, Maria P Mollica, Antonio Calignano, Giuseppina Mattace Raso
Pre- and post-natal factors can affect brain development and function, impacting health outcomes with particular relevance to neurodevelopmental diseases, such as autism spectrum disorders (ASDs). Maternal obesity and its associated complications have been related to the increased risk of ASDs in offspring. Indeed, animals exposed to maternal obesity or high fat diets are prone to social communication impairment and repetitive behavior, the hallmarks of autism. During development, fatty acids and sugars, as well as satiety hormones, like insulin and leptin, and inflammatory factors related to obesity-induced low grade inflammation, could play a role in the impairment of neuroendocrine system and brain neuronal circuits regulating behavior in offspring...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29535992/developmental-programming-of-renal-function-and-re-programming-approaches
#18
REVIEW
Eva Nüsken, Jörg Dötsch, Lutz T Weber, Kai-Dietrich Nüsken
Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29518483/hypothalamic-redox-balance-and-leptin-signaling-emerging-role-of-selenoproteins
#19
REVIEW
Ting Gong, Daniel J Torres, Marla J Berry, Matthew W Pitts
The hypothalamus is the central neural site governing food intake and energy expenditure. During the past 25 years, understanding of the hypothalamic cell types, hormones, and circuitry involved in the regulation of energy metabolism has dramatically increased. It is now well established that the adipocyte-derived hormone, leptin, acts upon two distinct groups of hypothalamic neurons that comprise opposing arms of the central melanocortin system. These two cell populations are anorexigenic neurons expressing proopiomelanocortin (POMC) and orexigenic neurons that express agouti-related peptide (AGRP)...
March 5, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29507217/high-salt-intake-causes-leptin-resistance-and-obesity-in-mice-by-stimulating-endogenous-fructose-production-and-metabolism
#20
Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nancy Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnson
Dietary guidelines for obesity typically focus on three food groups (carbohydrates, fat, and protein) and caloric restriction. Intake of noncaloric nutrients, such as salt, are rarely discussed. However, recently high salt intake has been reported to predict the development of obesity and insulin resistance. The mechanism for this effect is unknown. Here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
55462
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"