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dietary leptin

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https://www.readbyqxmd.com/read/28930270/protective-effects-of-six-selected-dietary-compounds-against-leptin-induced-proliferation-of-oestrogen-receptor-positive-mcf-7-breast-cancer-cells
#1
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew, E Dilip de Silva
BACKGROUND: Obesity is considered as one of the risk factors for breast cancer. Leptin has been found to be involved in breast cancer progression. Therefore, novel approaches to antagonize biological effects of leptin are much needed. The objective of this study was to evaluate the protective effects of six dietary compounds (quercetin, curcumin, gallic acid, epigallocatechin gallate (EGCG), ascorbic acid and catechin) and assess the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in leptin-stimulated MCF-7 breast cancer cells in vitro...
July 26, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28921841/in-a-randomized-trial-in-prostate-cancer-patients-dietary-protein-restriction-modifies-markers-of-leptin-and-insulin-signaling-in-plasma-extracellular-vesicles
#2
Erez Eitan, Valeria Tosti, Caitlin N Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P Mattson, Luigi Fontana
Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age-associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions...
September 17, 2017: Aging Cell
https://www.readbyqxmd.com/read/28904060/early-exposure-to-a-high-fat-high-sugar-diet-increases-the-mammary-stem-cell-compartment-and-mammary-tumor-risk-in-female-mice
#3
Isabel U Lambertz, Linjie Luo, Thomas R Berton, Scott L Schwartz, Stephen D Hursting, Claudio J Conti, Robin Fuchs-Young
Obesity and alterations in metabolic programming from early diet exposures can affect the propensity to disease in later life. Through dietary manipulation, developing mouse pups were exposed to a hyperinsulinemic, hyperglycemic milieu during three developmental phases: gestation, lactation and post-weaning. Analyses showed that a post-weaning high fat/high sugar (HF/HS) diet had the main negative effect on adult body weight, glucose tolerance and insulin resistance. However, dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis revealed that animals born to a mother fed a HF/HS gestation diet, nursed by a mother on a mildly diet-restricted, low fat/low sugar diet (DR) and weaned onto a HF/HS diet (HF/DR/HF) had the highest mammary tumor incidence, while HF/HF/DR had the lowest tumor incidence...
September 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28895540/polymorphism-rs3123554-in-the-cannabinoid-receptor-gene-type-2-cnr2-reveals-effects-on-body-weight-and-insulin-resistance-in-obese-subjects
#4
Daniel Antonio de Luis, Olatz Izaola, David Primo, Beatriz de la Fuente, Rocio Aller
BACKGROUND: Few studies assessing the relationship between single nucleotide polymorphisms in CNR2 and obesity or its related metabolic parameters are available. OBJECTIVE: To investigate the influence of polymorphism rs3123554 in the CNR2 receptor gene on obesity anthropometric parameters, insulin resistance, and adipokines in subjects with obesity. DESIGN: The study population consisted of 1027 obese subjects, who were performed bioelectrical impedance analyses, blood pressure measurements, serial assessments of dietary intake during three days, and biochemical tests...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28894948/cardiorespiratory-fitness-and-inflammatory-profile-on-cardiometabolic-risk-in-adolescents-from-the-labmed-physical-activity-study
#5
César A Agostinis-Sobrinho, Jonatan R Ruiz, Carla Moreira, Sandra Abreu, Lopes Luís, José Oliveira-Santos, Jorge Mota, Rute Santos
PURPOSE: We investigated the combined effect of cardiorespiratory fitness and the clustered score of inflammatory biomarkers (InflaScore) on the cardiometabolic risk score in adolescents. METHODS: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12-18 years. The shuttle run test was used to assess cardiorespiratory fitness. Continuous scores of clustered inflammatory biomarkers (high sensitivity C-reactive protein, complement factors C3 and C4, fibrinogen and leptin); cardiometabolic risk score (systolic blood pressure, triglycerides, ratio total cholesterol/HDL, HOMA-IR and waist circumference) were computed...
September 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28875870/a-priori-defined-diet-quality-indices-biomarkers-and-risk-for-type-2-diabetes-in-five-ethnic-groups-the-multiethnic-cohort
#6
Simone Jacobs, Carol J Boushey, Adrian A Franke, Yurii B Shvetsov, Kristine R Monroe, Christopher A Haiman, Laurence N Kolonel, Loic Le Marchand, Gertraud Maskarinec
Dietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases)...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28872427/long-term-dietary-supplementation-with-yerba-mate-ameliorates-diet-induced-obesity-and-metabolic-disorders-in-mice-by-regulating-energy-expenditure-and-lipid-metabolism
#7
Myung-Sook Choi, Hyo Jin Park, Sang Ryong Kim, Do Yeon Kim, Un Ju Jung
This study evaluated whether long-term supplementation with dietary yerba mate has beneficial effects on adiposity and its related metabolic dysfunctions in diet-induced obese mice. C57BL/6J mice were randomly divided into two groups and fed their respective experimental diets for 16 weeks as follows: (1) control group fed with high-fat diet (HFD) and (2) mate group fed with HFD plus yerba mate. Dietary yerba mate increased energy expenditure and thermogenic gene mRNA expression in white adipose tissue (WAT) and decreased fatty acid synthase (FAS) mRNA expression in WAT, which may be linked to observed decreases in body weight, WAT weight, epididymal adipocyte size, and plasma leptin level...
September 5, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28872363/docosahexaenoic-acid-dha-at-the-sn-2-position-of-triacylglycerols-increases-dha-incorporation-in-brown-but-not-in-white-adipose-tissue-of-hamsters
#8
Paula A Lopes, Narcisa M Bandarra, Susana V Martins, Marta S Madeira, Júlia Ferreira, José L Guil-Guerrero, José A M Prates
We hypothesised that the incorporation of docosahexaenoic acid (DHA) across adipose tissues will be higher when it is ingested as triacylglycerols (TAG) structured at the sn-2 position. Ten-week old male hamsters were allocated to 4 dietary treatments (n = 10): linseed oil (LSO-control group), fish oil (FO), fish oil ethyl esters (FO-EE) and structured DHA at the sn-2 position of TAG (DHA-SL) during 12 weeks. In opposition to the large variations found for fatty acid composition in retroperitoneal white adipose tissue (WAT), brown adipose tissue (BAT) was less responsive to diets...
September 5, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28869073/association-of-the-rs10830963-polymorphism-in-melatonin-receptor-type-1b-mtnr1b-with-metabolic-response-after-weight-loss-secondary-to-a-hypocaloric-diet-based-in-mediterranean-style
#9
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller
BACKGROUND & AIMS: Some genetic variants within MTNR1B were related with fasting glucose levels or the increased prevalence of diabetes mellitus and obesity. The aims of the present investigation were to determine the influence of rs10830963 MTNR1B variant in relation to body weight loss, insulin resistance and adipokine levels in response to a hypocaloric diet with Mediterranean pattern. METHODS: A Caucasian population of 80 obese patients was studied before and after 12 weeks on a hypocaloric diet...
August 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28855697/whey-protein-components-lactalbumin-and-lactoferrin-improve-energy-balance-and-metabolism
#10
Rizaldy C Zapata, Arashdeep Singh, Adel Pezeshki, Traj Nibber, Prasanth K Chelikani
Whey protein promotes weight loss and improves diabetic control, however, less is known of its bioactive components that produce such benefits. We compared the effects of normal protein (control) diet with high protein diets containing whey, or its fractions lactalbumin and lactoferrin, on energy balance and metabolism. Diet-induced obese rats were randomized to isocaloric diets: Control, Whey, Lactalbumin, Lactoferrin, or pair-fed to lactoferrin. Whey and lactalbumin produced transient hypophagia, whereas lactoferrin caused prolonged hypophagia; the hypophagia was likely due to decreased preference...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28823127/effects-of-feeding-corn-naturally-contaminated-with-aflatoxin-on-growth-performance-apparent-ileal-digestibility-serum-hormones-levels-and-gene-expression-of-na-k-atpase-in-ducklings
#11
Farzana Abbasi, Jingbo Liu, Hongfu Zhang, Xiaoyun Shen, Xuegang Luo
Objective: A 14-d trial was conducted to determine the effects of feeding corn naturally contaminated with aflatoxin B1 (AFB1) on growth performance, apparent ileal digestibility, serum hormones levels and gene expression of Na+, K+-ATPase in ducklings. Methods: A total of 704 ducklings were blocked on the basis of sex and body weight, and then allocated randomly to 1 of the following 2 treatments: 1) CON, basal diet and 2) AFB1, diets with 100% of normal corn replaced with AFB1 contaminated corn...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28818457/relationship-between-sleep-duration-and-childhood-obesity-systematic-review-including-the-potential-underlying-mechanisms
#12
REVIEW
R Felső, S Lohner, K Hollódy, É Erhardt, D Molnár
AIM: The prevalence of obesity is continually increasing worldwide. Determining risk factors for obesity may facilitate effective preventive programs. The present review focuses on sleep duration as a potential risk factor for childhood obesity. The aim is to summarize the evidence on the association of sleep duration and obesity and to discuss the underlying potential physiological and/or pathophysiological mechanisms. DATA SYNTHESIS: The Ovid MEDLINE, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for papers using text words with appropriate truncation and relevant indexing terms...
September 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28803009/involvement-of-plasma-adipokines-in-metabolic-and-reproductive-parameters-in-holstein-dairy-cows-fed-with-diets-with-differing-energy-levels
#13
N Mellouk, C Rame, J L Touzé, E Briant, L Ma, D Guillaume, D Lomet, A Caraty, T Ntallaris, P Humblot, J Dupont
This study aimed to investigate the association between plasma adipokine concentrations and metabolic and reproductive parameters in Holstein dairy cows fed diets with different energy levels during the peripartum period. The experiment started 1 mo before first calving and was maintained for 2 lactations. Dry matter intake and energy balance in animals fed a low-energy (LE) diet were significantly lower than that of animals fed a high-energy (HE) diet in the first lactation. Body weight, milk production, back fat thickness, and plasma concentrations of fatty acids, glucose, and insulin were not affected by diet, whereas plasma leptin and adiponectin concentrations were lower and plasma resistin concentrations higher in animals fed the LE diet...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28757576/the-association-between-cardiorespiratory-fitness-and-gut-microbiota-composition-in-premenopausal-women
#14
Yifan Yang, Yi Shi, Petri Wiklund, Xiao Tan, Na Wu, Xiaobo Zhang, Olli Tikkanen, Chenhong Zhang, Eveliina Munukka, Sulin Cheng
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19-49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0...
July 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28750045/effect-of-maternal-obesity-on-birthweight-and-neonatal-fat-mass-a-prospective-clinical-trial
#15
Delphine Mitanchez, Sophie Jacqueminet, Jacky Nizard, Marie-Laure Tanguy, Cécile Ciangura, Jean-Marc Lacorte, Céline De Carne, Laurence Foix L'Hélias, Pascale Chavatte-Palmer, Marie-Aline Charles, Marc Dommergues
OBJECTIVE: To discriminate the effect of maternal obesity and gestational diabetes on birth weight and adipose tissue of the newborn. METHODS: Normal BMI women (group N, n = 243; 18.5≤ BMI<25 kg/m2) and obese women (group Ob, n = 253; BMI≥30 kg/m2) were recruited in a prospective study between 15 and 18 weeks of gestation. All women were submitted to a 75g oral glucose tolerance test in the second and third trimester. First trimester fasting blood glucose was also obtained from Ob women...
2017: PloS One
https://www.readbyqxmd.com/read/28743192/searching-for-evidence-of-an-anti-inflammatory-diet-in-children-a-systematic-review-of-randomized-controlled-trials-for-pediatric-obesity-interventions-with-a-focus-on-leptin-ghrelin-and-adiponectin
#16
Kimberly A Lewis, Sharon A Brown
PROBLEM: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI)...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28727093/effects-of-intravenous-lipopolysaccharide-administration-on-feed-intake-ruminal-forage-degradability-and-liquid-parameters-and-physiological-responses-in-beef-cattle
#17
K D Lippolis, R F Cooke, K M Schubach, R S Marques, D W Bohnert
This experiment compared DMI, ruminal forage degradability, and liquid parameters as well as physiological responses in beef cattle receiving a lipopolysaccharide (LPS) challenge or not. Eight ruminally cannulated Angus × Hereford steers (485 ± 16 kg BW) were housed in individual pens on d -7, ranked by BW, and allocated to 1 of 2 treatments administered on d 0: 1) an intravenous (i.v.) bolus dose (0.5 μg/kg of BW, diluted in 5 mL of 0.9% sterile saline) of bacterial LPS ( 0111:B4) or 2) a 5-mL i.v. injection of 0...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727056/effects-of-protein-and-fat-concentration-in-coproduct-based-growing-calf-diets-on-adipogenic-and-lipogenic-gene-expression-blood-metabolites-and-carcass-composition
#18
J R Segers, J J Loor, S J Moisá, D Gonzalez, D W Shike
Crossbred calves ( = 30; age = 95 ± 1.7 d; BW = 179 ± 18 kg) were fed 1 of 5 growing diets: 1) corn-based control, 2) low-fat, low-protein coproduct blend, 3) high-fat, low-protein coproduct blend, 4) low-fat, high-protein coproduct blend, and 5) high-fat, high-protein coproduct blend for 112 d (growing phase) followed by a common corn-based finishing diet (additional 112 d; finishing phase). Calves were biopsied at 0, 112, and 224 d for transcriptional analysis via real-time quantitative PCR of 14 genes associated with adipogenesis and lipogenesis within the muscle...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727022/triennial-growth-and-development-symposium-genetics-and-breeding-for-intramuscular-fat-and-oleic-acid-content-in-pigs
#19
J Estany, R Ros-Freixedes, M Tor, R N Pena
The intramuscular fat (IMF) and oleic acid (OL) content have been favorably related to pork quality and human health. This influences the purchasing behavior of consumers and, therefore, also shifts the attention of breeding companies toward whether these traits are included into the breeding goal of the lines producing for high-valued markets. Because IMF and OL are unfavorably associated with lean content, a key economic trait, the real challenge for the industry is not simply to increase IMF and OL, but rather to come up with the right trade-off between them and lean content...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727020/interaction-of-dietary-energy-source-and-body-weight-gain-during-the-juvenile-period-on-metabolic-endocrine-status-and-age-at-puberty-in-beef-heifers
#20
C C Allen, L O Tedeschi, D H Keisler, R C Cardoso, B R C Alves, M Amstalden, G L Williams
Using a previously established model for nutritional acceleration of puberty, beef heifers ( = 48; 1/2 Angus × 1/4 Hereford × 1/4 Brahman) were used in a replicated 2 × 2 factorial design to examine the effects of diet type (high forage [HF] vs. high concentrate [HC]) and rate of BW gain (low gain [LG], 0.45 kg/d, vs. high gain [HG], 0.91 kg/d) on key metabolic hormones and age at puberty. After weaning at 14 ± 1 wk of age, heifers were assigned randomly to be fed HC-HG, HC-LG, HF-HG, or HF-LG ( = 12/group) beginning at 4 mo of age for 14 wk...
May 2017: Journal of Animal Science
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