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dietary leptin

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https://www.readbyqxmd.com/read/28632178/an-increased-dietary-supply-of-medium-chain-fatty-acids-during-early-weaning-in-rodents-prevents-excessive-fat-accumulation-in-adulthood
#1
Bert J M van de Heijning, Annemarie Oosting, Diane Kegler, Eline M van der Beek
Medium-chain fatty acids (MCFA) are a directly and readily absorbed source of energy. Exposure early-in-life to increased MCFA levels might affect development and impact (lipid) metabolism later in life. We tested whether an increased MCFA intake early-in-life positively affects adult body composition and metabolic status when challenged by a western-style diet (WSD). Male offspring of C57Bl/6j mice and Wistar rats were fed a control diet (CTRL; 10 w% fat, 14% MCFA) or a medium-chain triglycerides (MCT) diet with 20% MCFA until postnatal (PN) day 42, whereupon animals were fed a WSD (10 w% fat) until PN day 98...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28628401/dietary-red-and-processed-meat-intake-and-markers-of-adiposity-and-inflammation-the-multiethnic-cohort-study
#2
Weiwen Chai, Yukiko Morimoto, Robert V Cooney, Adrian A Franke, Yurii B Shvetsov, Loïc Le Marchand, Christopher A Haiman, Laurence N Kolonel, Marc T Goodman, Gertraud Maskarinec
OBJECTIVE: The potential influence of dietary factors on inflammation is important for cancer prevention. Utilizing data from control participants (312 men, 911 women) in 2 nested case-control studies of cancer within the Multiethnic Cohort, we examined the associations of red and processed meat intake with serum levels of leptin, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and the mediator effect of body mass index (BMI) on the above associations (if present)...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28617846/a-metabolite-of-leucine-%C3%AE-hydroxy-%C3%AE-methylbutyrate-given-to-sows-during-pregnancy-alters-bone-development-of-their-newborn-offspring-by-hormonal-modulation
#3
Tomasz Blicharski, Ewa Tomaszewska, Piotr Dobrowolski, Monika Hułas-Stasiak, Siemowit Muszyński
The effects of dietary β-hydroxy-β-methylbutyrate (HMB) supplementation during gestation on bone, growth plate, and articular cartilage in newborns were determined. Thermal analysis of articular cartilage was performed to examine the structural changes in collagen. At day 70 of gestation, a total of 12 sows (Large White Polish breed, at the second parity) were randomly assigned to two groups, with each group receiving either a basal diet or the same diet supplemented with 0.2 g/day HMB until the 90th day...
2017: PloS One
https://www.readbyqxmd.com/read/28599882/saponins-from-stems-and-leaves-of-panax-ginseng-prevent-obesity-via-regulating-thermogenesis-lipogenesis-and-lipolysis-in-high-fat-diet-induced-obese-c57bl-6-mice
#4
Guilin Chen, Haijun Li, Yan Zhao, Hongyan Zhu, Enbo Cai, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang
In this study, high-fat diet (HFD)-induced obesity in mouse model was used to evaluate the dietary effect of saponins from stems and leaves of Panax ginseng (SLG), and to explore its mechanism of action in producing anti-obesity effects. The results indicate that SLG showed significant anti-obesity effects in diet-induced obese mice, represented by decreased serum levels of free fatty acids (FFA), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, glucose, leptin and insulin, as well as a reduction in overall body and liver weight, epididymal adipose tissue weight, and food efficiency, and inhibition of abnormal increases in acyl carnitine levels normally caused by an HFD...
June 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28598548/eating-behavior-during-dexamethasone-treatment-in-children-with-acute-lymphoblastic-leukemia
#5
Lidewij T Warris, Erica L T van den Akker, Marc B Bierings, Cor van den Bos, Femke K Aarsen, Michel C Zwaan, Wim J E Tissing, Margreet A Veening, Rob Pieters, Marry M van den Heuvel-Eibrink
BACKGROUND AND AIM: Large prospective studies on dexamethasone-induced changes in eating behavior, energy, and nutrient intake are lacking in pediatric acute lymphoblastic leukemia (ALL). We prospectively studied eating behavior, energy, nutrient intake, and the effect on leptin and adiponectin levels during dexamethasone administration in children with ALL. PATIENTS: Parents of patients with ALL (3-16 years) completed a dietary diary for their child during 4 days of dexamethasone (6 mg/m(2) ) administration...
June 9, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28586412/high-fat-diet-and-female-fertility
#6
Natalie M Hohos, Malgorzata E Skaznik-Wikiel
The prevalence of obesity is high among reproductive age women and is associated with impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity result from overconsumption of a diet high in fat. Excess dietary fat increases both adipose and non-adipose tissue lipid content, and through lipotoxicity leads to cell dysfunction and death. High dietary fat intake, with or without the development of obesity, impairs female hypothalamic-pituitary-ovarian (HPO) axis functionality and fertility...
June 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/28586308/an-extract-from-the-atlantic-brown-algae-sacchorhiza-polyschides-counteracts-diet-induced-obesity-in-mice-via-a-gut-related-multi-factorial-mechanisms
#7
Patricia Huebbe, Sibylle Nikolai, Anke Schloesser, Diran Herebian, Graeme Campbell, Claus-Christian Glüer, Annette Zeyner, Tobias Demetrowitsch, Karin Schwarz, Cornelia C Metges, Thomas Roeder, Gerhard Schultheiss, Ignacio R Ipharraguerre, Gerald Rimbach
In this study we addressed the questions whether an Atlantic brown algae extract (BAE) affects diet induced obesity in mice and which would be the primary targets and underlying key mechanisms.Male C57 BL/6 mice were fed a hypercaloric diet, referred to as high fat diet (HFD), supplemented with a freeze-dried aqueous BAE from Sacchorizia polyschides (5 %) for 8 months. Compared to the control group, dietary BAE supplementation significantly attenuated increase in body weight and fat mass. We observed apparent metabolic improvement including normalization of blood glucose, reduced plasma leptin, reduced fecal bile salt hydrolase activity with lower microbial production of toxic bile acid metabolites in the gut and increased systemic bile acid circulation in BAE-fed mice counteracting adverse effects of long term HFD feeding...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28585195/eat-and-death-chronic-over-eating
#8
Atilla Engin
Obesity-related co-morbidities decrease life quality, reduce working ability and lead to early death. The total amount of dietary fat consumption may be the most potent food-related risk factor for weight gain. In this respect, dietary intake of high-caloric, high-fat diets due to chronic over-eating and sedentary lifestyle lead to increased storage of triglycerides not only in adipose tissue but also ectopically in other tissues . Increased plasma concentrations of non-esterified free fatty acids and lipid-overloaded hypertrophic adipocytes may cause insulin resistance in an inflammation-independent manner...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28577545/the-effect-of-a-prenatal-lifestyle-intervention-on-glucose-metabolism-results-of-the-norwegian-fit-for-delivery-randomized-controlled-trial
#9
Linda R Sagedal, Ingvild Vistad, Nina C Øverby, Elling Bere, Monica K Torstveit, Hilde Lohne-Seiler, Elisabet R Hillesund, Are Pripp, Tore Henriksen
BACKGROUND: The effectiveness of prenatal lifestyle intervention to prevent gestational diabetes and improve maternal glucose metabolism remains to be established. The Norwegian Fit for Delivery (NFFD) randomized, controlled trial studied the effect of a combined lifestyle intervention provided to a general population, and found significantly lower gestational weight gain among intervention participants but no improvement in obstetrical outcomes or the proportion of large infants. The aim of the present study is to examine the effect of the NFFD intervention on glucose metabolism, including an assessment of the subgroups of normal-weight and overweight/obese participants...
June 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28555008/different-intestinal-microbial-profile-in-over-weight-and-obese-subjects-consuming-a-diet-with-low-content-of-fiber-and-antioxidants
#10
Tania Fernández-Navarro, Nuria Salazar, Isabel Gutiérrez-Díaz, Clara G de Los Reyes-Gavilán, Miguel Gueimonde, Sonia González
Obesity has been related to an increased risk of multiple diseases in which oxidative stress and inflammation play a role. Gut microbiota has emerged as a mediator in this interaction, providing new mechanistic insights at the interface between fat metabolism dysregulation and obesity development. Our aim was to analyze the interrelationship among obesity, diet, oxidative stress, inflammation and the intestinal microbiota in 68 healthy adults (29.4% normal-weight). Diet was assessed through a food frequency questionnaire and converted into nutrients and dietary compounds using food composition tables...
May 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28551889/maternal-magnesium-restriction-elevates-glucocorticoid-stress-and-inflammation-in-the-placenta-and-fetus-of-wnin-rat-dams
#11
Anju Elizabeth Thomas, Padmavathi J N Inagadapa, Sugeetha Jeyapal, Naga Muralidhar Merugu, Rajender Rao Kalashikam, Raghunath Manchala
Magnesium plays a major role in many vital functions in the body. We reported earlier that maternal magnesium restriction altered body composition, fat metabolism, and insulin resistance in WNIN rat offspring and was associated with increased glucocorticoid stress in the offspring in their later life. We hypothesize that increased glucocorticoid stress and inflammation which originate in Mg restricted rat dams is transmitted through placenta to the fetus and underlie the metabolic disturbances in the later life of the offspring...
May 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28531393/the-rs10401670-variant-in-resistin-gene-improved-insulin-resistance-response-and-metabolic-parameters-secondaries-to-weight-loss-after-a-hypocaloric-diet
#12
Daniel Antonio de Luis, Rocío Aller, Olatz Izaola, David Primo, R Bachiller
BACKGROUND: The SNP 3'UTR C/T (rs10401670), it is a polymorphism that has been associated with diabetes mellitus and it has been scarcely studied before. As far as we know, no studies on interaction among diet intervention, rs10401670 variant of RETN and metabolic response has been realized. OBJECTIVE: Our aim was to analyze the effects of the rs10401670 RETN gene polymorphism on insulin resistance response and metabolic changes secondary to weight loss after 3 months of a hypocaloric diet in adults obese patients without diabetes mellitus...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28529818/high-protein-fish-oil-diet-prevents-hepatic-steatosis-in-noncnzo10-mice-association-with-diet-genetics-regulated-micro-rnas
#13
Nikhil Adi, Jennipher Adi, Roberta Marques Lassance-Soares, Paul Kurlansky, Hong Yu, Keith A Webster
OBJECTIVE: NONcNZO10 (NZ10) mice are predisposed to obesity and develop type 2 diabetes (T2D) and hepatic steatosis even when maintained on a control diet (CD) of 6% fat. Studies were designed to determine whether this extreme susceptibility phenotype could be alleviated by diet and if so the molecular targets of diet. METHODS: NZ10 and SWR/J (SWR) control mice were fed a CD or a test diet of high protein and fish oil (HPO) for 19 weeks and then analyzed for steatosis, blood chemistry, hepatic gene and micro-RNA expression...
June 2016: Journal of Diabetes & Metabolism
https://www.readbyqxmd.com/read/28521871/relation-of-antioxidant-capacity-of-diet-and-markers-of-oxidative-status-with-c-reactive-protein-and-adipocytokines-a-prospective-study
#14
Najada Stringa, Adela Brahimaj, Asija Zaciragic, Abbas Dehghan, Mohammad Arfan Ikram, Albert Hofman, Taulant Muka, Jessica C Kiefte-de Jong, Oscar H Franco
BACKGROUND: The role of dietary antioxidants and plasma oxidant-antioxidant status in low-grade chronic inflammation and adipocytokine levels is not established yet. OBJECTIVES: We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines. METHODS: Data of 4506 participants aged ≥55years from the Rotterdam Study were analyzed...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28514906/the-effects-of-gymnema-sylvestre-in-high-fat-diet-induced-metabolic-disorders
#15
Hyeon-Jeong Kim, Sanghwa Kim, Ah Young Lee, Yoonjeong Jang, Orkhonselenge Davaadamdin, Seong-Ho Hong, Jun Sung Kim, Myung-Haing Cho
This study used an integrated approach to investigate the effects of Gymnema sylvestre (GS) extract as a functional dietary supplement with a high-fat diet. This approach examined insulin resistance, the dysfunction of adipose tissue, and liver steatosis. Male C57BL/6J mice were fed a normal chow or high-fat diet (HFD) for the acute and chronic study, in addition to GS in different doses (100, 250 and 500[Formula: see text]mg/kg body weight). Their body composition changes, serum lipid and glucose parameters, adipose and liver tissue histology, and gene expression were measured...
May 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28511904/analysis-of-the-association-of-leptin-and-adiponectin-concentrations-with-metabolic-syndrome-in-children-results-from-the-idefics-study
#16
A Nappo, E M González-Gil, W Ahrens, K Bammann, N Michels, L A Moreno, Y Kourides, L Iacoviello, S Mårild, A Fraterman, D Molnàr, T Veidebaum, A Siani, P Russo
BACKGROUND AND AIMS: Adipokines may play a role in the pathogenesis of the metabolic syndrome (MetS) in children. We aimed to evaluate the association of leptin, adiponectin, and its ratio (L/A ratio) with the metabolic syndrome (MetS) in a subsample of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. METHODS AND RESULTS: Leptin, adiponectin and MetS parameters were measured in a subsample of 1253 children (3-9...
June 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28482370/dietary-isoflavone-dependent-and-estradiol-replacement-effects-on-body-weight-in-the-ovariectomized-ovx-rat
#17
Ashley L Russell, Jamie Moran Grimes, Danette F Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J Weiser, Michael R Landauer, Robert J Handa, T John Wu, Darwin O Larco
17β-Estradiol is known to regulate energy metabolism and body weight. Ovariectomy results in body weight gain while estradiol administration results in a reversal of weight gain. Isoflavones, found in rodent chow, can mimic estrogenic effects making it crucial to understand the role of these compounds on metabolic regulation. The goal of this study is to examine the effect of dietary isoflavones on body weight regulation in the ovariectomized rat. This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight...
May 8, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28481261/attenuating-the-biologic-drive-for-weight-regain-following-weight-loss-must-what-goes-down-always-go-back-up
#18
REVIEW
Christopher L Melby, Hunter L Paris, Rebecca M Foright, James Peth
Metabolic adaptations occur with weight loss that result in increased hunger with discordant simultaneous reductions in energy requirements-producing the so-called energy gap in which more energy is desired than is required. The increased hunger is associated with elevation of the orexigenic hormone ghrelin and decrements in anorexigenic hormones. The lower total daily energy expenditure with diet-induced weight loss results from (1) a disproportionately greater decrease in circulating leptin and resting metabolic rate (RMR) than would be predicted based on the decline in body mass, (2) decreased thermic effect of food (TEF), and (3) increased energy efficiency at work intensities characteristic of activities of daily living...
May 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28465000/long-term-soft-drink-and-aspartame-intake-induces-hepatic-damage-via-dysregulation-of-adipocytokines-and-alteration-of-the-lipid-profile-and-antioxidant-status
#19
Mohamed A Lebda, Hossam G Tohamy, Yasser S El-Sayed
Dietary intake of fructose corn syrup in sweetened beverages is associated with the development of metabolic syndrome and obesity. We hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. Therefore, this study intended to explore the expression of adipocytokines and its link to hepatic damage. Rats were assigned to drink water, cola soft drink (free access) and aspartame (240 mg/kg body weight/day orally) for 2 months. The lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines were evaluated...
May 2017: Nutrition Research
https://www.readbyqxmd.com/read/28443702/turmeric-supplementation-improves-serum-glucose-indices-and-leptin-levels-in-patients-with-nonalcoholic-fatty-liver-diseases
#20
Roya Navekar, Maryam Rafraf, Aida Ghaffari, Mohammad Asghari-Jafarabadi, Manouchehr Khoshbaten
OBJECTIVE: Insulin and leptin resistance are important risk factors for non-alcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD. The aim of this study was to investigate the effects of turmeric supplementation on glycemic status and serum leptin levels in patients with NAFLD. METHODS: This double-blind randomized controlled clinical trial was conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24...
May 2017: Journal of the American College of Nutrition
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