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https://www.readbyqxmd.com/read/28341134/metabolic-changes-in-droplet-vitrified-semen-of-wild-endangered-persian-sturgeon-acipenser-persicus-borodin-1997
#1
Amirreza Abed-Elmdoust, Hamid Farahmand, Bagher Mojazi-Amiri, Gholamreza Rafiee, Ruhollah Rahimi
Comparative quantitative metabolite profiling can be used for better understanding of cell functions and dysfunctions in particular circumstances such as sperm banking which is an important approach for cryopreservation of endangered species. Cryopreservation techniques have some deleterious effects on spermatozoa which put the obtained results in controversy. Therefore, in the present study, quantitative (1)H NMR (Nuclear Magnetic Resonance) based metabolite profiling was conducted to evaluate metabolite changes related to energetics and some other detected metabolites in vitrified semen of critically endangered wild Acipenser persicus...
March 21, 2017: Cryobiology
https://www.readbyqxmd.com/read/28328973/differing-metabolic-responses-to-salt-stress-in-wheat-barley-addition-lines-containing-different-7h-chromosomal-fragments
#2
Eva Darko, Krisztián Gierczik, Orsolya Hudák, Péter Forgó, Magda Pál, Edina Türkösi, Viktória Kovács, Sándor Dulai, Imre Majláth, István Molnár, Tibor Janda, Márta Molnár-Láng
Salinity-induced osmotic, ionic and oxidative stress responses were investigated on Asakaze/Manas wheat/barley addition lines 7H, 7HL and 7HS, together with their barley (salt-tolerant) and wheat (relatively salt-sensitive) parents. Growth, photosynthetic activity, chlorophyll degradation, proline, glycine betaine accumulation, sugar metabolism, Na+ and K+ uptake and transport processes and the role of polyamines and antioxidants were studied in young plants grown in hydroponic culture with or without salt treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28326634/influence-of-partial-or-total-replacement-of-glycerol-by-alternative-cryoprotectants-in-ghent-freezing-extender-on-post-thaw-sperm-quality-in-stallions
#3
R A De Oliveira, S Budik, C Aurich
Although glycerol is the cryoprotectant most commonly used in stallions, it has also a considerable toxicity for equine sperm. It was the aim of this study to analyse the quality of frozen-thawed stallion semen after complete or partial replacement of glycerol in the freezing extender by alternative cryoprotectants. We hypothesized that partial or total replacement of glycerol by cryoprotectants occurring in cold-resistant frog, insect or plant species results in similar or better semen quality after freezing-thawing...
March 21, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28317783/heat-induced-formation-of-mepiquat-by-decarboxylation-of-pipecolic-acid-and-its-betaine-derivative-part-2-natural-formation-in-cooked-vegetables-and-selected-food-products
#4
Yuan Yuan, Adrienne Tarres, Thomas Bessaire, Wilhelm Rademacher, Richard H Stadler, Thierry Delatour
Mepiquat (N,N-dimethylpiperidinium) is a plant growth regulator registered for use as its chloride salt in many countries on cereals and other crops. Recent model system studies have shown that natural chemicals present in crop plants, such as pipecolic acid and pipecolic acid betaine, may furnish mepiquat through different chemical pathways, when subjected to temperatures in the range of 200°C. In this study, we cooked raw vegetables that did not contain mepiquat to a palatable state using different traditional cooking methods, and detected mepiquat in 9 out of 11 oven-cooked vegetables, reaching up to 189μg/kg dry wt in oven-cooked broccoli...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28315457/anticonvulsant-activity-and-acute-neurotoxic-profile-of-achyranthes-aspera-linn
#5
Dinesh Y Gawande, Dmitry Druzhilovsky, Raghbir Chand Gupta, Vladimir Poroikov, Rajesh Kumar Goel
ETHNOPHARMACOLOGICAL RELEVANCE: Root powder of Achyranthes aspera Linn. (A. aspera) belongs to family Amaranthaceae is used in Indian traditional medicine for the management of epilepsy and its efficacy is widely acclaimed among the different rural communities. AIM OF THE STUDY: The present study was aimed to establish the possible anticonvulsant effect of A. aspera methanolic root extract using acute anticonvulsant models and to evaluate the acute toxicity and neurotoxic potential A...
March 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28300670/ergothioneine-products-derived-by-superoxide-oxidation-in-endothelial-cells-exposed-to-high-glucose
#6
Luigi Servillo, Nunzia D'Onofrio, Rosario Casale, Domenico Cautela, Alfonso Giovane, Domenico Castaldo, Maria Luisa Balestrieri
Ergothioneine (Egt), 2-mercapto-L-histidine betaine (ESH), is a dietary component acting as antioxidant and cytoprotectant. In vitro studies demonstrated that Egt, a powerful scavenger of hydroxyl radicals, superoxide anion, hypochlorous acid and peroxynitrite, protects vascular function against oxidative damages, thus preventing endothelial dysfunction. In order to delve the peculiar oxidative behavior of Egt, firstly identified in cell free-systems, experiments were designed to identify the Egt oxidation products when endothelial cells (EC) benefit of its protection against high-glucose (hGluc)...
March 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28296209/the-urinary-1-h-nmr-metabolomics-profile-of-an-italian-autistic-children-population-and-their-unaffected-siblings
#7
Milena Lussu, Antonio Noto, Alice Masili, Andrea C Rinaldi, Angelica Dessì, Maria De Angelis, Andrea De Giacomo, Vassilios Fanos, Luigi Atzori, Ruggiero Francavilla
Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of (1) H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n = 21) and controls (n = 21), these being siblings of autistic patients...
March 11, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28288879/betaine-homocysteine-s-methyltransferase-emerges-as-a-new-player-of-the-nuclear-methionine-cycle
#8
Juliana Pérez-Miguelsanz, Néstor Vallecillo, Francisco Garrido, Edel Reytor, Dolores Pérez-Sala, María A Pajares
The paradigm of a cytoplasmic methionine cycle synthesizing/eliminating metabolites that are transported into/out of the nucleus as required has been challenged by detection of significant nuclear levels of several enzymes of this pathway. Here, we show betaine homocysteine S-methyltransferase (BHMT), an enzyme that exerts a dual function in maintenance of methionine levels and osmoregulation, as a new component of the nuclear branch of the cycle. In most tissues, low expression of Bhmt coincides with a preferential nuclear localization of the protein...
March 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28281000/methylglyoxal-as-a-novel-signal-molecule-induces-the-salt-tolerance-of-wheat-by-regulating-the-glyoxalase-system-the-antioxidant-system-and-osmolytes
#9
Zhong-Guang Li, Xiang-Qiu Duan, Xiong Min, Zhi-Hao Zhou
Reactive carbonyl species methylglyoxal (MG) has always been regarded as a cytotoxic metabolite, but now is emerging to function as signal molecule in plants. However, whether MG can induce salt tolerance is elusive. In this study, treatment of wheat seeds with NaCl reduced seed germination, plant height, root length, fresh weight, and dry weight, indicating the inhibitive effects of NaCl on seed germination and seedling growth. The inhibitive effects of NaCl were alleviated by applying exogenous MG, but aggravated by the MG scavenger N-acetyl-L-cysteine (NAC), suggesting that MG could induce the salt tolerance of wheat...
March 9, 2017: Protoplasma
https://www.readbyqxmd.com/read/28278683/metabolomics-approach-to-chemical-diversity-of-the-mediterranean-marine-sponge-agelas-oroides
#10
Pierre Sauleau, Céline Moriou, Ali Al Mourabit
The Mediterranean marine sponge Agelas oroides is known to contain a large quantity of oroidin, a deterrent, antifouling and antibiofilm pyrrole-2-aminoimidazole. In contrast with other tropical specimens, the chemical composition of Mediterranean Agelas oroides is surprisingly relatively poor in other related metabolites. In the course of finding novel marine natural products, LC-MS based metabolomics study of the Mediterranean Agelas oroides, however, revealed that next to the major compound oroidin, the sponge contains in fact a great diversity of known pyrrole-imidazole alkaloids in minute amounts...
February 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28275217/identification-of-proteins-interacting-with-cytoplasmic-high-mobility-group-box-1-during-the-hepatocellular-response-to-ischemia-reperfusion-injury
#11
Tianjiao Zhang, Weiwei Wei, Olaf Dirsch, Thomas Krüger, Chunyi Kan, Chichi Xie, Olaf Kniemeyer, Haoshu Fang, Utz Settmacher, Uta Dahmen
Ischemia/reperfusion injury (IRI) occurs inevitably in liver transplantations and frequently during major resections, and can lead to liver dysfunction as well as systemic disorders. High-mobility group box 1 (HMGB1) plays a pathogenic role in hepatic IRI. In the normal liver, HMGB1 is located in the nucleus of hepatocytes; after ischemia reperfusion, it translocates to the cytoplasm and it is further released to the extracellular space. Unlike the well-explored functions of nuclear and extracellular HMGB1, the role of cytoplasmic HMGB1 in hepatic IRI remains elusive...
January 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28275104/dietary-choline-intake-is-directly-associated-with-bone-mineral-density-in-the-hordaland-health-study
#12
Jannike Øyen, Clara Gram Gjesdal, Therese Karlsson, Gard Ft Svingen, Grethe S Tell, Elin Strand, Christian A Drevon, Kathrine J Vinknes, Klaus Meyer, Per Magne Ueland, Ottar Nygård
Background: Choline is an important nutrient either obtained from a variety of foods or synthesized endogenously, and it is the precursor of betaine. We previously reported positive associations between plasma free choline and bone mineral density (BMD). Animal studies suggest an impact of dietary choline on bone metabolism, but the role of dietary intake of choline and betaine for human bone health is unknown.Objectives: The main aims were to examine the associations of dietary choline, choline species, and betaine with BMD and to study the relations between dietary and plasma free choline and betaine...
March 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28274419/heat-induced-formation-of-mepiquat-by-decarboxylation-of-pipecolic-acid-and-its-betaine-derivative-part-1-model-system-studies
#13
Yuan Yuan, Adrienne Tarres, Thomas Bessaire, Richard H Stadler, Thierry Delatour
This study describes, for the first time, the role of pipecolic acid betaine and pipecolic acid, naturally present in some foods, in the formation of the plant growth regulator N,N-dimethylpiperidinium (mepiquat) under dry thermal conditions. The formation of mepiquat and intermediate compounds was investigated in model systems using high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry. Mepiquat is released with a yield of up to 0.66mol% after thermal treatment (>150°C) of pipecolic acid betaine...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28272446/critical-role-of-quorum-sensing-dependent-glutamate-metabolism-in-homeostatic-osmolality-and-outer-membrane-vesiculation-in-burkholderia-glumae
#14
Yongsung Kang, Eunhye Goo, Jinwoo Kim, Ingyu Hwang
Metabolic homeostasis in cooperative bacteria is achieved by modulating primary metabolism in a quorum sensing (QS)-dependent manner. A perturbed metabolism in QS mutants causes physiological stress in the rice bacterial pathogen Burkholderia glumae. Here, we show that increased bacterial osmolality in B. glumae is caused by unusually high cellular concentrations of glutamate and betaine generated by QS deficiencies. QS negatively controls glutamate uptake and the expression of genes involved in the glutamine synthetase and glutamine oxoglutarate aminotransferase cycles...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266754/molybdenum-and-tungsten-imido-alkylidene-n-heterocyclic-carbene-catalysts-bearing-cationic-ligands-for-use-in-biphasic-olefin-metathesis
#15
Iris Elser, Roman Schowner, Wolfgang Frey, Michael Rudolf Buchmeiser
Ionic Mo- and W-imido alkylidene N-heterocyclic carbene (NHC) olefin metathesis catalysts, [Mo(N-2,6-Me2-C6H3)(CHCMe2Ph)(IMesH2)(OTf)(PPS)][OTf] (3), [Mo(N-2,6-Me2-C6H3)(CHCMe2Ph)(IMesH2)(OC6F5)(PPS)][B(ArF)4] (5), [Mo(N-tBu)(CHCMe2Ph)(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)(OTf)(2,6-Ph-4-(2,4,6-Ph-pyridinium)phenolate)][OTf] (9), [Mo(N-tBu)(CHCMe2Ph)(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)(2,6-Ph-4-(2,4,6-Ph-pyridinium)phenolate)][B(ArF)4]2 (10, PPS = pyridiniumpropanesulfonate, IMesH2 = 1,3-dimesitylimidazolin-2-ylidene, OTf = CF3SO3, B(ArF)4 = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate) were prepared from betaine-type ligands...
March 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28266133/effectiveness-of-a-polyhexanide-irrigation-solution-on-methicillin-resistant-staphylococcus-aureus-biofilms-in-a-porcine-wound-model
#16
Stephen C Davis, Andrew Harding, Joel Gil, Fernando Parajon, Jose Valdes, Michael Solis, Alex Higa
Irrigation and removal of necrotic debris can be beneficial for proper healing. It is becoming increasingly evident that wounds colonized with biofilm forming bacteria, such as Staphylococcus aureus (SA), can be more difficult to eradicate. Here we report our findings of the effects of an irrigation solution containing propyl-betaine and polyhexanide (PHMB) on methicillin-resistant Staphylococcus aureus (MRSA) biofilms in a porcine wound model. Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin...
March 7, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28266015/understanding-of-decreased-sialylation-of-fc-fusion-protein-in-hyperosmotic-recombinant-chinese-hamster-ovary-cell-culture-n-glycosylation-gene-expression-and-n-linked-glycan-antennary-profile
#17
Jong Hyun Lee, Yeong Ran Jeong, Yeon-Gu Kim, Gyun Min Lee
To understand the effects of hyperosmolality on protein glycosylation, recombinant Chinese hamster ovary (rCHO) cells producing the Fc-fusion protein were cultivated in hyperosmolar medium resulting from adding NaCl (415 mOsm/kg). The hyperosmotic culture showed increased specific Fc-fusion protein productivity (qFc ) but a decreased proportion of acidic isoforms and sialic acid content of the Fc-fusion protein. The intracellular and extracellular sialidase activities in the hyperosmotic cultures were similar to those in the control culture (314 mOsm/kg), indicating that reduced sialylation of Fc-fusion protein at hyperosmolality was not due to elevated sialidase activity...
March 7, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28263768/osmotic-shock-induced-protein-destabilization-in-living-cells-and-its-reversal-by-glycine-betaine
#18
Samantha S Stadmiller, Annelise H Gorensek-Benitez, Alex J Guseman, Gary J Pielak
Many organisms can adapt to changes in the solute content of their surroundings (i.e., the osmolarity). Hyperosmotic shock causes water efflux and a concomitant reduction in cell volume, which is countered by the accumulation of osmolytes. This volume reduction increases the crowded nature of the cytoplasm, which is expected to affect protein stability. In contrast to traditional theory, which predicts that more crowded conditions can only increase protein stability, recent work shows that crowding can destabilize proteins through transient attractive interactions...
March 2, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28260562/the-effect-of-paternal-methyl-group-donor-intake-on-offspring-dna-methylation-and-birth-weight
#19
S Pauwels, I Truijen, M Ghosh, R C Duca, S A S Langie, B Bekaert, K Freson, I Huybrechts, G Koppen, R Devlieger, L Godderis
Most nutritional studies on the development of children focus on mother-infant interactions. Maternal nutrition is critically involved in the growth and development of the fetus, but what about the father? The aim is to investigate the effects of paternal methyl-group donor intake (methionine, folate, betaine, choline) on paternal and offspring global DNA (hydroxy)methylation, offspring IGF2 DMR DNA methylation, and birth weight. Questionnaires, 7-day estimated dietary records, whole blood samples, and anthropometric measurements from 74 fathers were obtained...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28258367/enhancing-menaquinone-7-production-by-bacillus-natto-r127-through-the-nutritional-factors-and-surfactant
#20
Xue-Chao Hu, Wei-Ming Liu, Miao-Miao Luo, Lu-Jing Ren, Xiao-Jun Ji, He Huang
Bacillus natto is commonly used in industrial production of menaquinone-7, an important vitamin which plays a crucial role for blood clotting and may contribute to prevention of cardiovascular disease and osteoporosis. This study determined the optimal combination of key nutrients and established an effective use of surfactant in a coupling medium to enhance the yield of extracellular MK-7. MK-7 yield of 31.18 mg/L was achieved under optimal conditions containing 53.6 g/L glycerol, 100 g/L soy peptone, and 10 g/L K2HPO4...
March 3, 2017: Applied Biochemistry and Biotechnology
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