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https://www.readbyqxmd.com/read/29166571/protective-cerebrovascular-effects-of-hydroxysafflor-yellow-a-hsya-on-ischemic-stroke
#1
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
The purpose of the present work was designed to explore protective cerebrovascular effects of hydroxysafflor yellow A (HSYA), and provide preclinical efficacy and mechanism data for its possible application in patients with cerebral ischemia. The protective effect of HSYA on ischemic stroke was evaluated by infarct sizes and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Cerebrovascular permeability was detected by Evans blue dye leakage in MCAO rats. Cerebral blood flow, as well as blood pressure and heart rate were monitored using flow probes in Beagle dogs...
November 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29166378/blood-pressure-variability-is-independent-of-systolic-pressure-in-adolescent-and-young-adult-patients-undergoing-hemodialysis
#2
Jingjing Da, Zulong Zhang, Yan Shen, Qian Li, Ying Hu, Yan Zha
OBJECTIVE: Pre-dialysis blood pressure variability (BPV) in adolescent and young-adult maintenance hemodialysis (MHD) patients remains unknown. This study aimed to show the degree of 44-hour BPV and to explore its related risk factors in adolescent and young-adult MHD patients. METHOD: One hundred and fifty-three hemodialysis patients aged from 14 to 29 were selected from 11 medical facilities in Guizhou, China. Variability independent of mean BP (VIM) obtained by 44-hour ambulatory BP monitoring was used to calculate BPV...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29165595/con-the-role-of-diet-for-people-with-advanced-stage-5-ckd
#3
Graham Woodrow
Restriction of dietary protein intake has been used in the management of chronic kidney disease (CKD) for many decades, yet remains controversial, with marked variations in its application in clinical practice. There is extensive literature on the subject, with some expert opinion advocating the use of protein restriction based on the balance of the available evidence. The largest randomized trial of low-protein diets is the Modification of Diet in Renal Disease study. Despite multiple secondary analyses, the essential intention-to-treat analysis failed to demonstrate a benefit in the primary outcome of rate of decline of glomerular filtration rate...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165122/decreased-blood-pressure-associated-with-in-vehicle-exposure-to-carbon-monoxide-in-korean-volunteers
#4
Geon-Woo Lee, Mun-Joo Bae, Ji-Yeon Yang, Jung-Woo Son, Jae-Lim Cho, Sang-Gyu Lee, Bo-Mi Jang, Hyun-Woo Lee, Jong-Soon Lim, Dong-Chun Shin, Young-Wook Lim
BACKGROUND: Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car. METHODS: Human volunteers were exposed to CO concentrations of 0, 33...
April 5, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165060/relationship-between-race-and-outcome-in-asian-black-and-caucasian-patients-with-spontaneous-intracerebral-hemorrhage-data-from-the-virtual-international-stroke-trials-archive-and-efficacy-of-nitric-oxide-in-stroke-trial
#5
Kailash Krishnan, Lucy Beishon, Eivind Berge, Hanne Christensen, Robert A Dineen, Serefnur Ozturk, Nikola Sprigg, Joanna M Wardlaw, Philip M Bath
Background and purpose Although poor prognosis after intracerebral hemorrhage relates to risk factors and hematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods Data from 1011 patients with intracerebral hemorrhage enrolled into hyperacute trials and randomized to control were obtained from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. Clinical characteristics and functional outcome were compared among three racial groups - Asians, Blacks, and Caucasians...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29164841/home-blood-pressure-measurement-as-a-systematic-tool-for-clinical-practice-in-ckd-patients-a-real-world-picture
#6
Adamasco Cupisti, Lorenzo Ghiadoni, Claudia Zullo, Michele Marchini, Enrico Varricchio, Alessandro Puntoni, Elisabetta Giglio, Ophelia Meniconi, Maria R Bruno, Maria F Egidi
BACKGROUND: Arterial hypertension is very common in chronic kidney disease (CKD) patients and its prevalence increases with lowering estimated glomerular filtration rate (eGFR). Blood pressure (BP) control is a cornerstone in the treatment of CKD patients but still most treatment decisions are based on office BP measurement (OBPM). The aim of this cross-sectional, retrospective study is to investigate the prevalence of hypertension phenotypes in CKD patients and whether different home (HBPM) or OBPM are associated with a different CKD stage and cardiovascular comorbidities...
November 22, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/29164797/impact-of-systolic-blood-pressure-on-the-safety-and-tolerability-of-initiating-and-up-titrating-sacubitril-valsartan-in-patients-with-heart-failure-and-reduced-ejection-fraction-insights-from-the-titration-study
#7
Michele Senni, John J V McMurray, Rolf Wachter, Hugh F McIntyre, Inder S Anand, Vincenzo Duino, Arnab Sarkar, Victor Shi, Alan Charney
AIMS: The TITRATION trial investigated two strategies to initiate and up-titrate sacubitril/valsartan (LCZ696) to the same target dose, over a condensed (3-week) or conservative (6-week) period, in patients with heart failure with reduced ejection fraction (HFrEF) and systolic blood pressure (SBP) of ≥100 mmHg. This post hoc analysis examined the relationship between baseline SBP at screening and achievement of the target dose of sacubitril/valsartan of 97 mg/103 mg (also termed 'LCZ696 200 mg') twice per day during the study...
November 22, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29164683/is-hypertension-the-fate-of-aortic-coarctation-patients-treated-with-cheatham-platinum-cp-stent
#8
Ali Baykan, Ayse G Demiraldi, Onur Tasci, Ozge Pamukcu, Suleyman Sunkak, Kazım Uzum, Sadettin Sezer, Nazmi Narin
AIM: The aim of this study is to address the presence of hypertension and risk for cardiovascular diseases in patients with Coarctation of the Aorta (CoA) who were treated with endovascular stent placement. METHODS: Twenty patients (mean age: 14.2 ± 3.9 years) who were treated with stent and 20 age- and sex-matched controls were included to the study. Structure and functions of left ventricle were assessed by echocardiography. Carotid intima media (CIM) thickness was measured by using sonography as a marker for detecting cardiovascular risk...
November 21, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29164516/mineralocorticoid-receptor-antagonism-protects-the-aorta-from-vascular-smooth-muscle-cell-proliferation-and-collagen-deposition-in-a-rat-model-of-adrenal-aldosterone-producing-adenoma
#9
Yongji Yan, Chao Wang, Yiqin Lu, Huijie Gong, Zhun Wu, Xin Ma, Hongzhao Li, Baojun Wang, Xu Zhang
The number of patients with adrenal aldosterone-producing adenomas (APAs) has gradually increased. However, even after adenoma resection, some patients still suffer from high systolic blood pressure (SBP), which is possibly due to great arterial remodeling. Moreover, mineralocorticoid receptors (MRs) were found to be expressed in vascular smooth muscle cells (VSMCs). This study aims to determine whether MR antagonism protects the aorta from aldosterone-induced aortic remolding. Male rats were subcutaneously implanted with an osmotic minipumps and randomly divided into four groups: control; aldosterone (1 μg/h); aldosterone plus a specific MR antagonist, eplerenone (100 mg/kg/day); and aldosterone plus a vasodilator, hydralazine (25 mg/kg/day)...
November 21, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29164325/effects-of-recreational-football-on-women-s-fitness-and-health-adaptations-and-mechanisms
#10
REVIEW
Peter Krustrup, Eva Wulff Helge, Peter R Hansen, Per Aagaard, Marie Hagman, Morten B Randers, Maysa de Sousa, Magni Mohr
The review describes the fitness and health effects of recreational football in women aged 18-65 years. The review documents that 2 × 1 h of recreational football training for 12-16 weeks causes marked improvements in maximal oxygen uptake (5-15%) and myocardial function in women. Moreover, mean arterial blood pressure was shown to decrease by 2-5 mmHg in normotensive women and 6-8 mmHg in hypertensive women. This review also show that short-term (< 4 months) and medium-term (4-16 months) recreational football training has major beneficial impact on metabolic health profile in women, with fat losses of 1-3 kg and improvements in blood lipid profile...
November 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29164122/changes-in-expression-of-the-clock-gene-in-obstructive-sleep-apnea-syndrome-patients-are-not-reverted-by-continuous-positive-airway-pressure-treatment
#11
Susana Moreira, Raquel Rodrigues, André B Barros, Nadja Pejanovic, Ana Neves-Costa, Dora Pedroso, Cláudia Pereira, Dina Fernandes, João Valença Rodrigues, Cristina Barbara, Luís Ferreira Moita
Purpose: Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29164016/insights-in-public-health-ambulatory-blood-pressure-monitoring-underuse-in-clinical-practice-in-hawai-i
#12
Deborah Taira, Tetine Sentell, Cheryl Albright, Doug Lansidell, Kazuma Nakagawa, Todd Seto, Joel Mark Stevens
Hypertension is one of the leading causes of death and disability worldwide. Blood pressure reduction and control are associated with reduced risk of stroke and cardiovascular disease. To achieve optimal reduction and control, reliable and valid methods for blood pressure measurement are needed. Office based measurements can result in 'white coat' hypertension, which is when a patient's blood pressure in a clinical setting is higher than in other settings, or 'masked' hypertension, which occurs when a patient's blood pressure is normal in a clinical setting, but elevated outside the clinical setting...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29163991/an-undiagnosed-paraganglioma-in-a-58-year-old-female-who-underwent-tumor-resection
#13
William C Fox, Matthew Read, Richard E Moon, Eugene W Moretti, Brian J Colin
Paragangliomas and pheochromocytomas are rare neuroendocrine tumors that can have high morbidity and mortality if undiagnosed. Here we report a case of an undiagnosed paraganglioma in a 58-year-old female who underwent tumor resection. The patient became severely hypertensive intraoperatively with paroxysmal swings in blood pressure and then later became acutely hypotensive after tumor removal. She was managed in the surgical intensive care unit (SICU) postoperatively and discharged from the hospital without acute complications...
2017: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/29163986/the-salt-taste-threshold-in-untreated-hypertensive-patients
#14
Chang-Yeon Kim, Mi-Kyung Ye, Young Soo Lee
Background: The salt-taste threshold can influence the salt appetite, and is thought to be another marker of sodium intake. Many studies have mentioned the relationship between the sodium intake and blood pressure (BP). The aim of this study was to evaluate the relationship between the salt-taste threshold and urinary sodium excretion in normotensive and hypertensive groups. Methods: We analyzed 199 patients (mean age 52 years, male 47.3%) who underwent 24-h ambulatory BP monitoring (ABPM)...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29163735/urate-lowering-therapy-ameliorates-kidney-function-in-type-2-diabetes-patients-with-hyperuricemia
#15
Naohiko Ueno
Background: Hyperuricemia often causes kidney dysfunction which increases serum urate, forming a vicious cycle in the kidney. In this study, urate-lowering therapy was demonstrated in type 2 diabetic patients with hyperuricemia to evaluate the effect on diabetic nephropathy. Methods: Type 2 diabetic patients with hyperuricemia (n = 34) were treated by urate-lowering drugs. Serum urate levels, estimated glomerular filtration rate (eGFR), blood pressure, HbA1c, and urinary albumin-to-creatinine ratio (UACR) were measured for 52 weeks...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163354/diabetes-and-sepsis-risk-recurrence-and-ruination
#16
REVIEW
Lynn M Frydrych, Fatemeh Fattahi, Katherine He, Peter A Ward, Matthew J Delano
Sepsis develops when an infection surpasses local tissue containment. A series of dysregulated physiological responses are generated, leading to organ dysfunction and a 10% mortality risk. When patients with sepsis demonstrate elevated serum lactates and require vasopressor therapy to maintain adequate blood pressure in the absence of hypovolemia, they are in septic shock with an in-hospital mortality rate >40%. With improvements in intensive care treatment strategies, overall sepsis mortality has diminished to ~20% at 30 days; however, mortality continues to steadily climb after recovery from the acute event...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163214/predictive-value-of-dynamic-cerebral-autoregulation-assessment-in-surgical-management-of-patients-with-high-grade-carotid-artery-stenosis
#17
Vladimir B Semenyutin, Gregory A Asaturyan, Anna A Nikiforova, Vugar A Aliev, Grigory K Panuntsev, Vadim B Iblyaminov, Alexander V Savello, Andreas Patzak
Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#18
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162998/symptomatic-first-degree-atrioventricular-block-in-a-young-woman-after-taking-a-fat-burner-supplement
#19
Renda E M Abdelmageed, H B Xiao
A 22-year-old woman collapsed at home and was brought to the accident and emergency department. History revealed that she was fit and taken T5 capsule the night before the collapse. There was no history of similar collapses or seizure. Examination revealed blood pressure (BP) of 104/69 mmHg and a heart rate (HR) of 70 bpm. Chest, cardiovascular, and neurology examination were unremarkable. However, on standing, her HR increased to 120 bpm, and her BP dropped to 62/40 mmHg. Blood Na, K, Ca, Mg, phosphate, creatinine, complete blood count, T4 cortisol, and thyroid-stimulating hormone (TSH) were normal...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29162961/pisat-s-visual-vasopressor-injection-needle-a-new-device-for-increasing-patient-safety-in-laparoscopic-myomectomy
#20
REVIEW
Sanket V Pisat
Introduction: The use of vasopressin and other vasoconstrictive agents to reduce blood loss during laparoscopic myomectomy significantly reduces blood loss and operative time. However, serious cardiovascular complications following the use of intra-myometrial injection of vasopressin solution have also been reported. Most of these side effects are believed to be due to inadvertent intravascular injection of vasopressin solution. Aims and Objectives: To describe a new design of an injection needle, Pisat's Visual Vasopressor Injection Needle (VVIN), that can be used during laparoscopic myomectomy to minimise the incidence of an inadvertent intravascular injection of a vasoconstrictor solution...
December 2017: Journal of Obstetrics and Gynaecology of India
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