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SKI gene and cancer

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https://www.readbyqxmd.com/read/28681918/microrna-137-is-negatively-associated-with-clinical-outcome-and-regulates-tumor-development-through-ezh2-in-cervical-cancer
#1
Huimin Zhang, Ting Yan, Zhijun Liu, Jun Wang, Yu Lu, Donglin Li, Wentong Liang
PURPOSE: We intend to evaluate the expression, clinical relevance and functional role of microRNA-137 (miR-137) in human cervical cancer (CC). METHODS: MiR-137 expressions were assessed by qPCR in CC cell lines and human CC tumors. The correlation between endogenous miR-137 expression and CC Patients' postoperative overall survival was examined statistically. CC cell lines, Ca-Ski and SiHa cells were transduced with lentivirus to ectopically upregulate endogenous miR-137 expressions...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28577497/microrna-505-predicts-prognosis-and-acts-as-tumor-inhibitor-in-cervical-carcinoma-with-inverse-association-with-fzd4
#2
Chunhua Ma, Baomei Xu, Sulaiya Husaiyin, Lin Wang, Kunduozi Wusainahong, Jin Ma, Kaichun Zhu, Mayinuer Niyazi
PURPOSE: We investigated the expression and mechanisms of microRNA-505 (miR-505) and its downstream target gene Frizzled-4 (FZD4) in cervical cancer. METHODS: miR-505 expression was evaluated by qRT-PCR in cervical cancer cell lines and human carcinomas. Cancer patients' clinicopathological factors and survival were analyzed based on their tumorous miR-505 levels. Ca-Ski and HeLa cells were transduced with lentivirus to upregulate or downregulate miR-505. Their impacts on cervical cancer were evaluated by in vitro proliferation, invasion and in vivo tumorigenicity assays, respectively...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28521287/5azadc-treatment-upregulates-mir-375-level-and-represses-hpv16-e6-expression
#3
Adrien Morel, Aurélie Baguet, Jérôme Perrard, Caroline Demeret, Elise Jacquin, David Guenat, Christiane Mougin, Jean-Luc Prétet
High-risk human papillomaviruses are the etiological agents of cervical cancer and HPV16 is the most oncogenic genotype. Immortalization and transformation of infected cells requires the overexpression of the two viral oncoproteins E6 and E7 following HPV DNA integration into the host cell genome. Integration often leads to the loss of the E2 open reading frame and the corresponding protein can no longer act as a transcriptional repressor on p97 promoter. Recently, it has been proposed that long control region methylation also contributes to the regulation of E6/E7 expression...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487767/inducement-of-apoptosis-by-cucurbitacin-e-a-tetracyclic-triterpenes-through-death-receptor-5-in-human-cervical-cancer-cell-lines
#4
Ya-Min Cheng, Ching-Ju Shen, Chi-Chang Chang, Cheng-Yang Chou, Ching-Chou Tsai, Yi-Chiang Hsu
Cervical cancer is the most common malignancy in women, for which conization or hysterectomy are the main therapy. Curcubitacin E (Cu E) is a natural compound-based drug which from the Guadi (climbing stem of Cucumic melo L). Previously shown to be an anti-tumor as well as a potent chemopreventive agent against several types of tumors. The present study, investigated anti-proliferation and apoptosis induced by Cu E in cervical cancer cell lines (HeLa and Ca Ski). The results indicate that the cytotoxicity is associated with accumulation in apoptosis but not necrosis...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28398634/ski-regulates-smads-and-taz-signaling-to-suppress-lung-cancer-progression
#5
Mian Xie, Xiaojun Wu, Jinjun Zhang, Jiexia Zhang, Xiangxiang Li
Ski, the transforming protein of the avian Sloan-Kettering retrovirus, displays both pro-oncogenic and anti-oncogenic activities in human cancer. The mechanisms underlying these conflicting observations have not been fully understood. Herein, we investigated the mechanism underlying the tumor suppressor activity of Ski. To investigate the effect of Ski re-activation on TGF-β and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15(INK4B) ) and TAZ target gene CTGF. The results revealed that Ski exerted its inhibitory activity in TGF-β1/Smad signaling pathway...
April 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28165392/sphingosine-kinase-1-involves-the-inhibitory-action-of-hif-1%C3%AE-by-chlorogenic-acid-in-hypoxic-du145-cells
#6
Myoung-Sun Lee, Seon-Ok Lee, Kyu-Ri Kim, Hyo-Jeong Lee
Hypoxia enhances cancer development in a solid tumor. Hypoxia-inducible factor-1 α (HIF-1α) is a transcription factor that is dominantly expressed under hypoxia in solid tumor cells and is a key factor that regulates tumor. HIF-1α regulates several target genes involved in many aspects of cancer progression, including angiogenesis, metastasis, anti-apoptosis and cell proliferation as well as imparts resistance to cancer treatment. In this study, we assessed Crataegus Pinnatifida Bunge var. typical Schneider ethanol extract (CPE) for its anti-cancer effects in hypoxia-induced DU145 human prostate cancer cell line...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28115165/repression-of-smad3-by-stat3-and-c-ski-snon-induces-gefitinib-resistance-in-lung-adenocarcinoma
#7
Yojiro Makino, Jeong-Hwan Yoon, Eunjin Bae, Mitsuyasu Kato, Keiji Miyazawa, Tatsuo Ohira, Norihiko Ikeda, Masahiko Kuroda, Mizuko Mamura
Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. Stat3-mediated interleukin (IL)-6 signaling and Smad-mediated transforming growth factor-β (TGF-β) signaling pathways play crucial regulatory roles in cancer-associated inflammation. However, mechanisms how these pathways regulate sensitivity and resistance to EGFR-TKI in NSCLCs remain largely undetermined...
March 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27909446/functional-toxicogenomic-profiling-expands-insight-into-modulators-of-formaldehyde-toxicity-in-yeast
#8
Matthew North, Brandon D Gaytán, Carlos Romero, Vanessa Y De La Rosa, Alex Loguinov, Martyn T Smith, Luoping Zhang, Chris D Vulpe
Formaldehyde (FA) is a commercially important chemical with numerous and diverse uses. Accordingly, occupational and environmental exposure to FA is prevalent worldwide. Various adverse effects, including nasopharyngeal, sinonasal, and lymphohematopoietic cancers, have been linked to FA exposure, prompting designation of FA as a human carcinogen by U.S. and international scientific entities. Although the mechanism(s) of FA toxicity have been well studied, additional insight is needed in regard to the genetic requirements for FA tolerance...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27137215/identification-of-key-regulators-of-pancreatic-cancer-progression-through-multidimensional-systems-level-analysis
#9
Deepa Rajamani, Manoj K Bhasin
BACKGROUND: Pancreatic cancer is an aggressive cancer with dismal prognosis, urgently necessitating better biomarkers to improve therapeutic options and early diagnosis. Traditional approaches of biomarker detection that consider only one aspect of the biological continuum like gene expression alone are limited in their scope and lack robustness in identifying the key regulators of the disease. We have adopted a multidimensional approach involving the cross-talk between the omics spaces to identify key regulators of disease progression...
May 3, 2016: Genome Medicine
https://www.readbyqxmd.com/read/26944438/sphk1-inhibitor-ski-ii-inhibits-the-proliferation-of-human-hepatoma-hepg2-cells-via-the-wnt5a-%C3%AE-catenin-signaling-pathway
#10
Hong Liu, Cai-Xia Zhang, Yan Ma, Hong-Wei He, Jia-Ping Wang, Rong-Guang Shao
AIM: Sphingosine 1-phosphate (S1P) promotes cell growth, proliferation and survival. Sphingosine kinase 1 (SphK1), which converts sphingosine to S1P, is a key promoter in cancer. We previously found that the SphK1 inhibitor II (SKI II), suppresses the cell growth and induces apoptosis in human hepatoma HepG2 cells. However, the precise regulatory mechanism and signaling pathway on SKI II inhibiting tumor growth remains unknown. MAIN METHODS: The expressions of β-catenin and related molecules of Wnt/β-catenin signal were detected by western blot in HepG2 cells...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26766902/microrna-125a-5p-modulates-human-cervical-carcinoma-proliferation-and-migration-by-targeting-abl2
#11
Xian Qin, Yajun Wan, Saiying Wang, Min Xue
BACKGROUND: In this study, we intended to understand the regulatory mechanisms of microRNA-125a-5p (miR-125a-5p) in human cervical carcinoma. METHODS: The gene expressions of miR-125a-5p in seven cervical carcinoma cell lines and 12 human cervical carcinoma samples were evaluated by quantitative real-time reverse transcription polymerase chain reaction. Ca-Ski and HeLa cells were transduced with lentivirus carrying miR-125a-5p mimics, and the effects of lentivirus-induced miR-125a-5p upregulation on cervical carcinoma proliferation and migration were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and transwell assays, respectively...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26293898/the-anti-ovarian-cancer-activity-by-wye-132-a-mtorc1-2-dual-inhibitor
#12
Dan Zhang, Hexia Xia, Wei Zhang, Bo Fang
Epithelial ovarian cancer is the most common and lethal gynecological cancer in USA and around the world, causing major mortality annually. In the current study, we investigated the potential anti-ovarian cancer activity of WYE-132, a mammalian target of rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor. Our results showed that WYE-132 potently inhibited proliferation of primary and established human ovarian cancer cells. Meanwhile, WYE-132 induced caspase-dependent apoptosis in ovarian cancer cells. At the molecular level, WYE-132 blocked mTORC1/2 activation and inhibited expression of mTOR-regulated genes (cyclin D1 and hypoxia-inducible factor 1α)...
January 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26208712/l-and-d-lactate-enhance-dna-repair-and-modulate-the-resistance-of-cervical-carcinoma-cells-to-anticancer-drugs-via-histone-deacetylase-inhibition-and-hydroxycarboxylic-acid-receptor-1-activation
#13
Waldemar Wagner, Wojciech M Ciszewski, Katarzyna D Kania
BACKGROUND: The consideration of lactate as an active metabolite is a newly emerging and attractive concept. Recently, lactate has been reported to regulate gene transcription via the inhibition of histone deacetylases (HDACs) and survival of cancer cells via hydroxycarboxylic acid receptor 1 (HCAR1). This study examined the role of L- and D-lactate in the DNA damage response in cervical cancer cells. METHODS: Three cervical cancer cell lines were examined: HeLa, Ca Ski and C33A...
2015: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/26073604/the-swi-snf-subunit-ini1-contains-an-n-terminal-winged-helix-dna-binding-domain-that-is-a-target-for-mutations-in-schwannomatosis
#14
Mark D Allen, Stefan M V Freund, Giovanna Zinzalla, Mark Bycroft
SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit is mutated in both malignant rhabdoid tumor, a highly aggressive childhood cancer, and schwannomatosis, a tumor-predisposing syndrome characterized by mostly benign tumors of the CNS. Here, we show that mutations in INI1 that cause schwannomatosis target a hitherto unidentified N-terminal winged helix DNA binding domain that is also present in the BAF45a/PHF10 subunit of the SWI/SNF complex...
July 7, 2015: Structure
https://www.readbyqxmd.com/read/25585689/genome-wide-association-study-for-posthitis-in-the-free-living-population-of-european-bison-bison-bonasus
#15
Kamil Oleński, Małgorzata Tokarska, Dorota Hering, Paulina Puckowska, Anna Ruść, Cino Pertoldi, Stanisław Kamiński
BACKGROUND: About 5-6% of the European bison (Bison bonasus) males are affected by posthitis (necrotic inflammation of the prepuce) and die in the wild forest. Despite many years of study, pathogenesis of this disease has not yet been determined. The main aim of the study was to find SNP markers significantly associated with the incidence of posthitis and mine the genome for candidate genes potentially involved in the development of the disease. RESULTS: It was shown that relatively small number of SNPs effects reached genome-wide significance after false discovery rate (FDR) correction...
2015: Biology Direct
https://www.readbyqxmd.com/read/25379706/expression-of-the-p53-target-wig-1-is-associated-with-hpv-status-and-patient-survival-in-cervical-carcinoma
#16
Li-Di Xu, Susanne Muller, Srinivasan R Thoppe, Fredrik Hellborg, Lena Kanter, Mikael Lerner, Biying Zheng, Svetlana Bajalica Lagercrantz, Dan Grandér, Keng Ling Wallin, Klas G Wiman, Catharina Larsson, Sonia Andersson
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and the encoded Wig-1 protein in cervical carcinoma cell lines and tumor tissue samples. Our analysis of eight cervical cancer lines (Ca Ski, ME-180, MS751, SiHa, SW756, C-4I, C-33A, and HT-3) by spectral karyotype, comparative genomic hybridization and Southern blotting revealed WIG-1 is not the primary target for chromosome 3 gains...
2014: PloS One
https://www.readbyqxmd.com/read/25311137/pdgf-beta-targeting-in-cervical-cancer-cells-suggest-a-fine-tuning-of-compensatory-signalling-pathways-to-sustain-tumourigenic-stimulation
#17
Oana Mihaela Tudoran, Olga Soritau, Loredana Balacescu, Laura Pop, Guillaume Meurice, Simona Visan, Staffan Lindberg, Alexandru Eniu, Ulo Langel, Ovidiu Balacescu, Ioana Berindan-Neagoe
The platelet-derived growth factor (PDGF) signalling pathway has been reported to play an important role in human cancers by modulating autocrine and paracrine processes such as tumour growth, metastasis and angiogenesis. Several clinical trials document the benefits of targeting this pathway; however, in cervical cancer the role of PDGF signalling in still unclear. In this study, we used siRNA against PDGF beta (PDGFBB) to investigate the cellular and molecular mechanisms of PDGFBB signalling in Ca Ski and HeLa cervical cancer cells...
February 2015: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/25153718/sphk1-regulates-proliferation-and-survival-responses-in-triple-negative-breast-cancer
#18
Arpita Datta, Ser Yue Loo, Baohua Huang, Lingkai Wong, Sheryl S L Tan, Tuan Zea Tan, Soo-Chin Lee, Jean Paul Thiery, Yaw Chyn Lim, Wei Peng Yong, Yulin Lam, Alan Prem Kumar, Celestial T Yap
Triple-negative breast cancer (TNBC) is characterized by unique aggressive behavior and lack of targeted therapies. Among the various molecular subtypes of breast cancer, it was observed that TNBCs express elevated levels of sphingosine kinase 1 (SPHK1) compared to other breast tumor subtypes. High levels of SPHK1 gene expression correlated with poor overall and progression- free survival, as well as poor response to Doxorubicin-based treatment. Inhibition of SPHK1 was found to attenuate ERK1/2 and AKT signaling and reduce growth of TNBC cells in vitro and in a xenograft SCID mouse model...
August 15, 2014: Oncotarget
https://www.readbyqxmd.com/read/25010868/sphk1-regulates-proliferation-and-survival-responses-in-triple-negative-breast-cancer
#19
Arpita Datta, Ser Yue Loo, Baohua Huang, Lingkai Wong, Sheryl S L Tan, Tuan Zea Tan, Soo-Chin Lee, Jean Paul Thiery, Yaw Chyn Lim, Wei Peng Yong, Yulin Lam, Alan Prem Kumar, Celestial T Yap
Triple-negative breast cancer (TNBC) is characterized by unique aggressive behavior and lack of targeted therapies. Among the various molecular subtypes of breast cancer, it was observed that TNBCs express elevated levels of sphingosine kinase 1 (SPHK1) compared to other breast tumor subtypes. High levels of SPHK1 gene expression correlated with poor overall and progression- free survival, as well as poor response to Doxorubicin-based treatment. Inhibition of SPHK1 was found to attenuate ERK1/2 and AKT signaling and reduce growth of TNBC cells in vitro and in a xenograft SCID mouse model...
March 27, 2014: Oncotarget
https://www.readbyqxmd.com/read/24817966/skip-expression-is-correlated-with-clinical-prognosis-in-patients-with-bladder-cancer
#20
Longwang Wang, Mei Zhang, Yong Wu, Cheng Cheng, Yawei Huang, Zimin Shi, Hongwei Huang
The Ski-interacting protein (SKIP) is a transcriptional cofactor distinct from other cofactors and is involved in regulation of many cancer-related proteins. However, its distribution and clinical significances in bladder cancer remains poorly understood. In this study, Quantitative real-time PCR and immunohistochemistry were performed to detect the expression of SKIP in clinical bladder cancer samples. In addition, the correlation of SKIP expression and clinicopathological features and clinical outcomes were analyzed...
2014: International Journal of Clinical and Experimental Pathology
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