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Ken G Andersson, Maryam Oroujeni, Javad Garousi, Bogdan Mitran, Stefan Ståhl, Anna Orlova, John Löfblom, Vladimir Tolmachev
The epidermal growth factor receptor (EGFR) is overexpressed in a number of malignant tumors and is a molecular target for several specific anticancer antibodies and tyrosine kinase inhibitors. The overexpression of EGFR is a predictive biomarker for response to several therapy regimens. Radionuclide molecular imaging might enable detection of EGFR overexpression by a non-invasive procedure and could be used repeatedly. Affibody molecules are engineered scaffold proteins, which could be selected to have a high affinity and selectivity to predetermined targets...
October 5, 2016: International Journal of Oncology
Ruofei Bu, Hillel Price, Sorin Mitran, Carlton Zdanski, Amy L Oldenburg
Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing computational fluid dynamics modeling to aid in surgical decision-making...
2016: Proceedings of SPIE
Javad Garousi, Sarah Lindbo, Hadis Honarvar, Justin Velletta, Bogdan Mitran, Mohamed Altai, Anna Orlova, Vladimir Tolmachev, Sophia Hober
Radionuclide imaging-based stratification of patients to targeted therapies makes cancer treatment more personalized and therefore more efficient. ADAPTs (ABD Derived Affinity ProTeins) constitute a novel group of imaging probes based on the scaffold of an albumin-binding domain (ABD). To evaluate how different compositions of the N-terminal sequence of ADAPTs influence their biodistribution, a series of human epidermal growth factor receptor type 2 (HER2)-binding ADAPT6 derivatives with different N-terminal sequences were created: GCH6DANS (2), GC(HE)3DANS (3), GCDEAVDANS (4) and GCVDANS(5) and compared with the parental variant: GCSS(HE)3DEAVDANS (1)...
October 14, 2016: Bioconjugate Chemistry
Javad Garousi, Hadis Honarvar, Ken G Andersson, Bogdan Mitran, Anna Orlova, Jos Buijs, John Löfblom, Fredrik Y Frejd, Vladimir Tolmachev
Overexpression of the enzyme carbonic anhydrase IX (CAIX) is documented for chronically hypoxic malignant tumors as well as for normoxic renal cell carcinoma. Radionuclide molecular imaging of CAIX would be useful for detection of hypoxic areas in malignant tumors, for patients' stratification of CAIX-targeted therapies and for discrimination of primary malignant and benign renal tumors. Earlier, we have reported feasibility of in vivo radionuclide based imaging of CAIX expressing tumors using Affibody molecules, small affinity proteins based on a non-immunoglobulin scaffold...
August 16, 2016: Molecular Pharmaceutics
Ying Zhang, Isaac Nault, Sorin Mitran, Edwin S Iversen, Pei Zhong
The effects of stone size on the process and comminution efficiency of shock wave lithotripsy (SWL) were investigated in experiments, numerical simulations and scale analysis. Cylindrical BegoStone phantoms with approximately equal height and diameter of either 4, 7 or 10 mm, in a total aggregated mass of about 1.5 g, were treated in an electromagnetic shock wave lithotripter field. The resultant stone comminution was found to correlate closely with the average peak pressure, P+(avg), incident on the stones...
November 2016: Ultrasound in Medicine & Biology
Cory W Quammen, Russell M Taylor, Pavel Krajcevski, Sorin Mitran, Andinet Enquobahrie, Richard Superfine, Brad Davis, Stephanie Davis, Carlton Zdanski
The Virtual Pediatric Airways Workbench (VPAW) is a patient-centered surgical planning software system targeted to pediatric patients with airway obstruction. VPAW provides an intuitive surgical planning interface for clinicians and supports quantitative analysis regarding prospective surgeries to aid clinicians deciding on potential surgical intervention. VPAW enables a full surgical planning pipeline, including importing DICOM images, segmenting the airway, interactive 3D editing of airway geometries to express potential surgical treatment planning options, and creating input files for offline geometric analysis and computational fluid dynamics simulations for evaluation of surgical outcomes...
2016: Studies in Health Technology and Informatics
Kristina Westerlund, Hadis Honarvar, Emily Norrström, Joanna Strand, Bogdan Mitran, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
A promising strategy to enable patient stratification for targeted therapies is to monitor the target expression in a tumor by radionuclide molecular imaging. Affibody molecules (7 kDa) are nonimmunoglobulin scaffold proteins with a 25-fold smaller size than intact antibodies. They have shown an apparent potential as molecular imaging probes both in preclinical and clinical studies. Earlier, we found that hepatic uptake can be reduced by the incorporation of negatively charged purification tags at the N-terminus of Affibody molecules...
May 2, 2016: Molecular Pharmaceutics
Bogdan Mitran, Zohreh Varasteh, Ram Kumar Selvaraju, Gunnar Lindeberg, Jens Sörensen, Mats Larhed, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Bombesin (BN) analogs bind with high affinity to gastrin-releasing peptide receptors (GRPRs) that are up-regulated in prostate cancer and can be used for the visualization of prostate cancer. The aim of this study was to investigate the influence of radionuclide-chelator complexes on the biodistribution pattern of the 111In-labeled bombesin antagonist PEG2-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (PEG2-RM26) and to identify an optimal construct for SPECT imaging. A series of RM26 analogs N-terminally conjugated with NOTA, NODAGA, DOTA and DOTAGA via a PEG2 spacer were radiolabeled with 111In and evaluated both in vitro and in vivo...
May 2016: International Journal of Oncology
Nirmalendu Basak, Ashim Datta, Tarik Mitran, Biswapati Mandal, P K Mani
Long-term use of organic and mineral inputs has an overriding impact on soil biological and metabolic activities and crop management. Farm yard manure (FYM), paddy straw (PS) and green manure (GM, Sesbania sesban L.) were used for 24- years old rice (Oyza sativa L.) -wheat (Triticum aestivum L.) cropping system in sub-tropical India to predict whether the screened soil biological and metabolic activities are correlated with system yield. The integrated approaches viz., NPK + FYM, NPK + PS and NPK + GM significantly increased both rice and wheat yield together by 67...
January 2016: Journal of Environmental Biology
D Berger, S Nastase, R A Mitran, M Petrescu, E Vasile, C Matei, T Negreanu-Pirjol
Oxytetracycline delivery systems containing various MCM-type silica and aluminosilicate with different antibiotic content were developed in order to establish the influence of the support structural and textural properties and aluminum content on the drug release profile. The antibiotic molecules were loaded into the support mesochannels by incipient wetness impregnation method using a drug concentrated aqueous solution. The carriers and drug-loaded materials were investigated by small- and wide-angle XRD, FTIR spectroscopy, TEM and N2 adsorption-desorption isotherms...
August 30, 2016: International Journal of Pharmaceutics
Javad Garousi, Ken G Andersson, Bogdan Mitran, Marie-Louise Pichl, Stefan Ståhl, Anna Orlova, John Löfblom, Vladimir Tolmachev
Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor, which is overexpressed in many types of cancer. The use of EGFR-targeting monoclonal antibodies and tyrosine-kinase inhibitors improves significantly survival of patients with colorectal, non-small cell lung cancer and head and neck squamous cell carcinoma. Detection of EGFR overexpression provides important prognostic and predictive information influencing management of the patients. The use of radionuclide molecular imaging would enable non-invasive repeatable determination of EGFR expression in disseminated cancer...
April 2016: International Journal of Oncology
Mohamed Altai, Anna Perols, Maria Tsourma, Bogdan Mitran, Hadis Honarvar, Marc Robillard, Raffaella Rossin, Wolter ten Hoeve, Mark Lubberink, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
UNLABELLED: Affibody molecules constitute a new class of probes for radionuclide tumor targeting. The small size of Affibody molecules is favorable for rapid localization in tumors and clearance from circulation. However, high renal reabsorption of Affibody molecules prevents the use of residualizing radiometals, including several promising low-energy β- and α-emitters, for radionuclide therapy. We tested a hypothesis that Affibody-based pretargeting mediated by a bioorthogonal interaction between trans-cyclooctene (TCO) and tetrazine would provide higher accumulation of radiometals in tumor xenografts than in the kidneys...
March 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Valentina Mitran, Cora Vasilescu, Silviu Iulian Drob, Petre Osiceanu, Jose Maria Calderon-Moreno, Mariana-Cristina Tabirca, Doina-Margareta Gordin, Thierry Gloriant, Anisoara Cimpean
The influence of gas nitriding surface treatment on the superelastic Ti-23Nb-0.7Ta-2Zr-0.5N alloy was evaluated. A thorough characterization of bare and nitrided Ti-based alloy and pure Ti was performed in terms of surface film composition and morphology, electrochemical behaviour, and short term osteoblast response. XPS analysis showed that the nitriding treatment strongly influenced the composition (nitrides and oxynitrides) and surface properties both of the substrate and of the bulk alloy. SEM images revealed that the nitrided surface appears as a similar dotted pattern caused by the formation of N-rich domains coexisting with less nitrided domains, while before treatment only topographical features could be observed...
2015: BioMed Research International
G A Nemnes, C Goehry, T L Mitran, Adela Nicolaev, L Ion, S Antohe, N Plugaru, A Manolescu
Rutile-TiO2/hybrid halide perovskite CH3NH3PbI3-xClx interfaces are investigated by ab initio density functional theory calculations. The role of chlorine in achieving enhanced solar cell power conversion efficiencies is in the focus of recent studies, which point to increased carrier mobilities, reduced recombination rates, a driven morphology evolution of the perovskite layer and improved carrier transport across the interface. As it was recently established that chlorine is preferentially localized in the vicinity of the interface and not in the bulk of the perovskite layer, we analyze the changes introduced in the electronic properties by varying the chlorine concentration near the interface...
November 11, 2015: Physical Chemistry Chemical Physics: PCCP
Sake Johannes van der Wall, Victor A W M Umans, Jeroen Schotten, Mitran Keijzers, Ron Wolterbeek, Evert K Jansen, Menno V Huisman, Alexander B A Vonk
OBJECTIVES: After elective aortic valve replacement, patients are at risk of developing valve thrombosis and systemic arterial thromboembolism. Current guidelines recommend antithrombotic therapy with aspirin or vitamin K antagonists (VKAs) during the first 3 months after the procedure, but have level 2 or 3 evidence. As a consequence, the most appropriate antithrombotic therapy is still a matter of debate. This retrospective study analysed all thromboembolic and bleeding complications in patients with either antiplatelet or anticoagulation therapy 1 year after bioprosthetic aortic valve replacement...
April 2016: European Journal of Cardio-thoracic Surgery
Carlton Zdanski, Stephanie Davis, Yi Hong, Di Miao, Cory Quammen, Sorin Mitran, Brad Davis, Marc Niethammer, Julia Kimbell, Elizabeth Pitkin, Jason Fine, Lynn Fordham, Bradley Vaughn, Richard Superfine
OBJECTIVES/HYPOTHESIS: Determine whether quantitative geometric measures and a computational fluid dynamic (CFD) model derived from medical imaging of children with subglottic stenosis (SGS) can be effective diagnostic and treatment planning tools. STUDY DESIGN: Retrospective chart and imaging review in a tertiary care hospital. METHODS: Computed tomography scans (n = 17) of children with SGS were analyzed by geometric and CFD methods...
May 2016: Laryngoscope
Gregory J Herschlag, Sorin Mitran, Guang Lin
We develop a hierarchy of approximations to the master equation for systems that exhibit translational invariance and finite-range spatial correlation. Each approximation within the hierarchy is a set of ordinary differential equations that considers spatial correlations of varying lattice distance; the assumption is that the full system will have finite spatial correlations and thus the behavior of the models within the hierarchy will approach that of the full system. We provide evidence of this convergence in the context of one- and two-dimensional numerical examples...
June 21, 2015: Journal of Chemical Physics
B Safeenaz Alladin-Mustan, Catherine J Mitran, Julianne M Gibbs-Davis
The ability to amplify nucleic acid biomarkers at room temperature has remained elusive despite the great need of diagnostics suitable for the point of care. To exponentially amplify DNA within a wide range of ambient temperatures (18-26 °C), we explore combining two destabilizing elements in our isothermal lesion-induced DNA amplification system. We demonstrate rapid DNA amplification at the bench without a heat source.
June 4, 2015: Chemical Communications: Chem Comm
Bogdan Cătălin, Smaranda Mitran, Mihai Ciorbagiu, Eugen Osiac, Tudor Adrian Bălşeanu, LaurenŢiu Mogoantă, Sorin Nicolae Dinescu, Carmen Valeria Albu, Cecil Sorin Mirea, Ionică Daniel Vîlcea, Maria Iancău, Veronica Sfredel
Alzheimer's disease (AD) determines gradual loss of cognition and memory function, eventually leading to clinical manifest dementia. The pathogenic mechanisms of AD remain elusive and treatment options unsatisfactory, targeting only symptoms like memory loss, behavior changes, sleep disorders and seizures. These therapies are not stopping the disease's progression, at their best they can only delay it. Accumulating evidence suggests that AD is associated with a microglial dysfunction. Microglia are resident immune cells that provide continuous surveillance within the brain...
2015: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Zohreh Varasteh, Bogdan Mitran, Ulrika Rosenström, Irina Velikyan, Maria Rosestedt, Gunnar Lindeberg, Jens Sörensen, Mats Larhed, Vladimir Tolmachev, Anna Orlova
INTRODUCTION: Overexpression of gastrin-releasing peptide receptors (GRPR) has been reported in several cancers. Bombesin (BN) analogs are short peptides with a high affinity for GRPR. Different BN analogs were evaluated for radionuclide imaging and therapy of GRPR-expressing tumors. We have previously investigated an antagonistic analog of BN (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH(2), RM26) conjugated to NOTA via a PEG(2) spacer (NOTA-PEG(2)-RM26) labeled with (68)Ga, (111)In and Al(18)F...
May 2015: Nuclear Medicine and Biology
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