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Echo 3 D trans

Ramin S Sahebjavaher, Guy Nir, Mohammad Honarvar, Louis O Gagnon, Joseph Ischia, Edward C Jones, Silvia D Chang, Ladan Fazli, S Larry Goldenberg, Robert Rohling, Piotr Kozlowski, Ralph Sinkus, Septimiu E Salcudean
The purpose of this work was to assess trans-perineal prostate magnetic resonance elastography (MRE) for (1) repeatability in phantoms/volunteers and (2) diagnostic power as correlated with histopathology in prostate cancer patients. The three-dimensional (3D) displacement field was obtained using a fractionally encoded gradient echo sequence using a custom-made transducer. The repeatability of the method was assessed based on three repeat studies and by changing the driving frequency by 3% in studies on a phantom and six healthy volunteers...
January 2015: NMR in Biomedicine
Ofer Havakuk, Michal Entin-Meer, Jeremy Ben-Shoshan, Pavel Goryainov, Sofia Maysel-Auslender, Erel Joffe, Gad Keren
BACKGROUND: Vitamin D has been shown to induce beneficial effects on cardiovascular and renal morbidity by regulating inflammation and tissue fibrosis. OBJECTIVES: To evaluate the effect of vitamin D analogues on cardiac function and fibrosis in an animal model of cardiorenal syndrome. METHODS: Unilateral nephrectomy was performed and myocardial infarction induced in rats. The rats were treated with vitamin D receptor activator (VDRA, paricalcitol, 40 ng/250 g x 3/week) versus a vehicle...
November 2013: Israel Medical Association Journal: IMAJ
Selma F Mohammed, Jimmy R Storlie, Elise A Oehler, Lorna A Bowen, Josef Korinek, Carolyn S P Lam, Robert D Simari, John C Burnett, Margaret M Redfield
BACKGROUND: In mice, transverse aortic constriction (TAC) is variably characterized as a model of pressure overload-induced hypertrophy (left ventricular [LV] hypertrophy, or LVH) or heart failure (HF). While commonly used, variability in the TAC model is poorly defined. The objectives of this study were to characterize the variability in the TAC model and to define a simple, noninvasive method of prospectively identifying mice with HF versus compensated LVH after TAC. METHODS: Eight-week-old male C57BL/6J mice underwent TAC or sham and then echocardiography at 3 weeks post-TAC...
May 2012: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Alexander Kulik, Roy G Masters, Pierre Bédard, Paul J Hendry, B-Khanh Lam, Fraser D Rubens, Thierry G Mesana, Marc Ruel
OBJECTIVE: Bioprosthesis structural valve deterioration (SVD) is an incompletely understood process involving the accumulation of calcium and lipids. Whether this process could be delayed with lipid-lowering therapy (LLT) is currently unknown. The purpose of this observational study was to evaluate if an association exists between early LLT and a slowing of bioprosthesis SVD, with a view to designing a prospective trial. METHODS: We followed 1193 patients who underwent aortic valve replacement with contemporary bioprostheses between 1990 and 2006 (mean follow-up 4...
January 2010: European Journal of Cardio-thoracic Surgery
A Schumacher, Ev Khojeini, Df Larson
Most patients with cardiac disease have diastolic dysfunction which is characterized by impaired diastolic filling and/or abnormal diastolic relaxation. The trans-esophageal echocardiography (TEE) used routinely during open-heart surgical procedures has exceptional resolution that may permit the identification and grading of diastolic dysfunction. The goal of this study was to determine which echocardiography (ECHO) parameters can best describe diastolic dysfunction due to myocardial remodeling and fibrosis...
September 2008: Perfusion
Nial J Wheate, P G Anil Kumar, Allan M Torres, Janice R Aldrich-Wright, William S Price
The self-diffusion of cucurbit[7]uril (CB[7]) and its host-guest complexes in D2O has been examined using pulsed gradient spin-echo nuclear magnetic resonance spectroscopy. CB[7] diffuses freely at a concentration of 2 mM with a diffusion coefficient (D) of 3.07 x 10(-10) m(2) s(-1). At saturation (3.7 mM), CB[7] diffuses more slowly (D = 2.82 x 10(-10) m(2) s(-1)) indicating that it partially self-associates. At concentrations between 2 and 200 mM, CsCl has no effect on the diffusion coefficient of CB[7] (1 mM)...
February 28, 2008: Journal of Physical Chemistry. B
R H Wu, G Guo, Y P Zhang, H Tran, K terBrugge, D Mikulis
The perfect shimming of 31P magnetic resonance spectroscopy (MRS) is not easy in vivo. The purpose of this study was to examine the feasibility of using 1H MRS shimming values to obtain 31P spectra in a same sequence. Both phantom and volunteer studies were carried out in this study. Phantom was a sphere filled with physiological metabolites of brain. In vivo study was performed on 4 healthy volunteers. The studies were performed on a 3-T GE scanner. A same localizer and a same cursor were used for both 1H and 31P scans...
2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Iain P Wharton, Ian H Rivens, Gail R Ter Haar, David J Gilderdale, David J Collins, Jeff W Hand, Paul D Abel, Nandita M deSouza
PURPOSE: To integrate a high intensity focused ultrasound (HIFU) transducer with an MR receiver coil for endocavitary MR-guided thermal ablation of localized pelvic lesions. MATERIALS AND METHODS: A hollow semicylindrical probe (diameter 3.2 cm) with a rectangular upper surface (7.2 cm x 3.2 cm) was designed to house a HIFU transducer and enable acoustic contact with an intraluminal wall. The probe was distally rounded to ease endocavitary insertion and was proximally tapered to a 1...
March 2007: Journal of Magnetic Resonance Imaging: JMRI
Tran-Chin Yang, Brian M Hoffman
We extend earlier studies of the effects of relaxation on the intensities of pulsed ENDOR signals by introducing a Davies/Hahn (D/H) pulsed ENDOR multi-sequence that corresponds to a series of Davies sequences with the preparation pulse 'turned off'. In this pulse train, the Hahn [pi/2, pi] detection pulse pair of sequence n-1 both generates the echo detected for that sequence and acts as the preparation portion of sequence n, in effect replacing the pi preparation pulse of the Davies sequence. We show both theoretically, through a master-equation approach, and with both (1)H(I=1/2) and (14)N(I=1) ENDOR experiments on the non-heme Fe enzymes, superoxide reductase (SOR) (S=1/2) and AntDO (S=3/2), that under conditions of high electron-spin polarization (high microwave frequency/low temperature) the D/H multi-sequence allows simplification of ENDOR spectra by suppression of nuclear transitions associated with the m(S)=+1/2 (alpha) manifold...
August 2006: Journal of Magnetic Resonance
Christian A Sandoval, Yoshiki Yamaguchi, Takeshi Ohkuma, Koichi Kato, Ryoji Noyori
The solution structures of a number of trans-RuH(eta(1)-BH(4))[(S)-tolbinap](1,2-diamine) precatalysts [TolBINAP = 2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl; 1,2-diamine==(S,S)- or (R,R)-1,2-diphenylethylenediamine (DPEN), ethylenediamine (EN), and (S)-1,1-di(4-anisyl)-2-isopropylethylenediamine (DAIPEN)] have been determined using 2D NMR ((1)H--(1)H DQF-COSY, (1)H--(13)C HMQC, (1)H--(31)P HSQC, and (1)H--(15)N HSQC), and a double-pulsed field-gradient spin-echo (DPFGSE) NOE technique. All the octahedral Ru complexes adopt a trans configuration with respect to the BH(4) and hydride ligands...
January 2006: Magnetic Resonance in Chemistry: MRC
M E Miquel, D L G Hill, E J Baker, S A Qureshi, R D B Simon, S F Keevil, R S Razavi
The present study was designed to evaluate the feasibility and clinical usefulness of three-dimensional (3D) reconstruction of intra-cardiac anatomy from a series of two-dimensional (2D) MR images using commercially available software. Sixteen patients (eight with structurally normal hearts but due to have catheter radio-frequency ablation of atrial tachyarrhythmias and eight with atrial septal defects (ASD) due for trans-catheter closure) and two volunteers were imaged at 1T. For each patient, a series of ECG-triggered images (5 mm thick slices, 2-3 mm apart) were acquired during breath holding...
June 2003: International Journal of Cardiovascular Imaging
Massimo Fiori, Roberta Gunelli, Eduard Bercovich
Traditional 2-D ultrasound is a fast, inexpensive, non-invasive procedure and may be used routinely for the pre and post-operative evaluation of patients with various grade of cystocele, but a new tool in ultrasound investigation is recently available: the 3D scan. Our aim is to assess the real usefulness of 3D scan in the evaluation of cystocele grade. 15 women with clinical and urodynamic findings of genuine stress incontinence and grade 2-3 cystocele (in accord to Baden-Walker grading) underwent both ultrasonographic 3D imaging and traditional 2D trans labial scan with Convex probe (3...
December 2002: Archivio Italiano di Urologia, Andrologia
Christopher S Dodson, Andrey V Peresypkin, Kalpana Rengarajan, Shaoxiong Wu, John M Nickerson
PURPOSE: Diffusion coefficients of various retinoids have not been measured previously. It is important to know the diffusion coefficients of the retinoids because this property might be rate-limiting in dark adaptation. Also, retinoid diffusion is important to explore given that rhodopsin regeneration is not impaired in IRBP knockout mice. METHODS: Measurements of lateral diffusion coefficients (D) of 9-cis-retinal, all-trans-retinal, and all-trans-retinol were made by Fourier transform pulsed-gradient spin-echo NMR measurements (FT-PGSE NMR) in several solvents...
January 2002: Current Eye Research
Stephan Deblon, Lorenz Liesum, Jeffrey Harmer, Hartmut Schönberg, Arthur Schweiger, Hansjörg Grützmacher
The 17-electron complexes [M(tropp(ph))2] (M=Co0, Rh0, Ir0) were prepared and isolated (tropp = tropylidene phosphane). A structural analysis of [Co(tropp(ph))2] revealed this complex to be almost tetrahedral, while the heavier homologues have more planar structures. Partially deuterated tropp complexes [D6][M(tropp(ph))2] were synthesised for M = Rh and Ir in order to enhance the resolution in the EPR spectra. This synthesis involves a four-fold intramolecular C-H activation reaction, whereby alkyl groups are transformed into olefins...
February 2, 2002: Chemistry: a European Journal
Lenny M. Carruthers, Christina L. Closken, Karen L. Link, Surendra N. Mahapatro, Malavosklish Bikram, Jing-Long Du, Sandra S. Eaton, Gareth R. Eaton
A new method to prepare Cr(NO)(H(2)O)(5)(2+) from dichromate and NH(2)OH is reported. The chromium nitrosyls Cr(NO)(EHBA)(+) and Cr(NO)(EHBA)(2) (EHBA = 2-ethyl-2-hydoxybutyrate) were prepared by a literature reaction and characterized by continuous wave electron paramagnetic resonance and two-pulse electron spin echo spectroscopy at X-band. The g values are characteristic of a single unpaired electron in a predominantly d(xy)() orbital. In fluid and glassy solutions Cr(NO)(EHBA)(2) is a mixture of cis and trans isomers...
July 26, 1999: Inorganic Chemistry
M Dueholm, M L Jensen, H Laursen, P Kracht
BACKGROUND: To combine findings of normal mid-line echoes from TVS (trans-vaginal sonography) with cut-off levels for endometrial thickness, in order to examine the associated risk of abnormalities in the uterine cavity. DESIGN AND SETTING: Two center prospective study at a university clinic and a central hospital in Denmark. PARTICIPANTS: Three hundred and fifty-five pre-menopausal patients with abnormal uterine bleeding, and indications for endometrial sampling or surgery...
July 2001: Acta Obstetricia et Gynecologica Scandinavica
S G Horne, R N Anderson, I Burwash, C Koilpillai, D E Johnstone, E R Smith
BACKGROUND: Septal systolic motion is determined by the end-diastolic trans-septal pressure gradient, and hence is load dependent. OBJECTIVE: To explore septal contribution to left ventricular (LV) systolic function in patients with heart failure. DESIGN: Echocardiograms were identified post hoc from normal subjects and a cohort of patients with heart failure. PATIENTS: Twelve normal subjects and 69 patients with heart failure and normal conduction or left bundle brance block (LBBB) were studied...
November 2000: Canadian Journal of Cardiology
R Stephen, P D Darbre
Although retinoids are known to be inhibitory to breast cancer cell growth, a key remaining question is whether they would remain effective if administered long-term. We describe here the long-term effects of all- trans retinoic acid on two oestrogen-dependent human breast cancer cell lines MCF7 and ZR-75-1. Although both cell lines were growth inhibited by retinoic acid in the short-term in either the absence or the presence of oestradiol, prolonged culture with 1 microM all- trans retinoic acid resulted in the cells acquiring resistance to the growth inhibitory effects of retinoic acid...
November 2000: British Journal of Cancer
S H Park, W C Gray, I Hernandez, M Jacobs, R A Ord, M Sutharalingam, R G Smith, D A Van Echo, S Wu, B A Conley
Although retinoids show promise for prevention of second primary upper aerodigestive tract tumors, the optimum retinoid, dose, and schedule are unknown. All-trans retinoic acid (ATRA) has greater affinity for retinoic acid receptors and may be more active than other retinoids but has a shorter plasma half life and may up-regulate its own metabolism. We defined the maximum long-term tolerable dose, dosing frequency, pharmacokinetics, and toxicity of ATRA in patients with treated squamous cell carcinoma of the head and neck (SCCHN)...
March 2000: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
D Mathieu, M Paret, A E Mahfouz, F Caseiro-Alves, J Tran Van Nhieu, M C Anglade, A Rahmouni, N Vasile
BACKGROUND: To determine the incidence of hyperintensity on T1-weighted spin echo (SE) images in benign liver lesions, value of fat-suppressed magnetic resonance (MR) imaging for the detection of fat within these lesions, and the causes of hyperintensity by correlation to pathologic examinations. METHODS: Five hundred forty-nine patients with 805 benign liver lesions including 585 hemangiomas, 188 focal nodular hyperplasias (FNHs), 14 hepatic adenomas (HAs), 14 focal fatty infiltrations (FFIs), two biliary cystadenomas, and two hemorrhagic cysts were examined by T2-weighted and T1-weighted SE MR imaging...
July 1997: Abdominal Imaging
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