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JOURNAL ARTICLE
Julian Smith-Voudouris, Lee E Rubin, Jonathan N Grauer
INTRODUCTION: Total knee arthroplasty (TKA) is a common procedure for which patient factors are known to affect perioperative outcomes. Asthma has not been specifically considered in this regard, although it is the most common inflammatory airway disease and predisposes to osteoarthritis. METHODS: Adult patients undergoing TKA were identified from 2015 to 2021-Q3 M157 PearlDiver data sets. Asthma patients were matched to those without 1:1 based on age, sex, and Elixhauser Comorbidity Index (ECI)...
April 18, 2024: Journal of the American Academy of Orthopaedic Surgeons
#22
JOURNAL ARTICLE
D Nóbrega-Catelas, A L Correia, F Cordeiro, P Teixeira-da-Mota
Acute calcific periarthritis (ACP) in the interphalangeal joints of the hand is rare, with less than 100 cases reported. A rare case of ACP in a proximal interphalangeal (PIP) joint of the hand, in a young black woman, after acute trauma, is presented. She experienced severe pain and limited range of motion, and was medicated with an oral corticoid, which was followed by a rapid resolution of the symptoms. At six months, there were no signs of clinical or radiographic recurrence. Recognition of ACP allows for avoiding unnecessary treatments...
2024: Acta Ortopédica Mexicana
#23
REVIEW
I F Rodríguez-Rodríguez, P Navarro-Torres-Arpi, A Dryjanski-Lerner, J G Gómez-Mont-Landerreche, G A Levy-Holden, F Gil-Orbezo
Discoid meniscus is a congenital morphological variant of the meniscus, which tends to occur more frequently in its lateral form than in the medial form. This anomaly is characterized by central hypertrophy of the meniscus and a larger diameter than the normal meniscus, resulting in an abnormal shape and greater coverage of the tibial plateau. The clinical presentation of this condition varies depending on the stability of the meniscus. In pediatric patients, in particular, it is common to experience progressive and atraumatic symptoms, such as pain and limited mobility...
2024: Acta Ortopédica Mexicana
#24
JOURNAL ARTICLE
Saurabh Rohatgi, Amol Dua, Andrea Diociasi, Karen Buch, Arman Avesta, Jeremy Ford, Rajiv Gupta
OBJECTIVE: Radiological imaging is pivotal in diagnosing idiopathic normal pressure hydrocephalus (iNPH), given the similarity of its symptoms to other neurodegenerative diseases. We aimed to correlate the Evans index (EI), callosal angle (CA), and the volume of the lateral ventricles measured before cerebrospinal fluid removal with the resultant outcomes in gait response. METHODS: In our retrospective study, we identified 42 patients with a diagnosis of iNPH. These patients underwent gait analysis, imaging, and lumbar puncture...
April 24, 2024: Journal of Computer Assisted Tomography
#25
JOURNAL ARTICLE
Liang Ma, Youyou Fang, Ni Yang, Ning Li, Lai Chen, Duanyun Cao, Yun Lu, Qing Huang, Tinglu Song, Yuefeng Su, Feng Wu
The poor bulk-phase and interphase stability, attributable to adverse internal stress, impede the cycling performance of silicon microparticles (μSi) anodes and its commercial application for high-energy-density lithium-ion batteries. In this work, we propose a groundbreaking gradient-hierarchically ordered conductive (GHOC) network structure, ingeniously engineered to enhance the stability of both bulk-phase and the solid electrolyte interphase (SEI) configurations of μSi. Within the GHOC network architecture, two-dimensional transition metal carbides (Ti3 C2 Tx ) acts as a conductive "brick", establishing a highly conductive inner layer on μSi, while the porous outer layer, composed of one-dimensional Tempo-oxidized cellulose nanofibers (TCNF) and polyacrylic acid (PAA) macromolecule, functions akin to structural "rebar" and "concrete", effectively preserves the tightly interconnected conductive framework though multiple bonding mechanisms, including covalent and hydrogen bonds...
April 24, 2024: Advanced Materials
#26
JOURNAL ARTICLE
Somayya Naguib, Lamiaa A Mansour, Neveen A Soliman, Hadeel M El-Hanafy, Yosra A Fahmy, Mohamed A Elmonem, Radwa M Abdel Halim
Introduction: Approximately 80% of primary hyperoxaluria cases are caused by primary hyperoxaluria type 1 (PH1, OMIM# 259900), which is characterized by pathogenic variants in the AGXT gene, resulting in deficiency of the liver-specific enzyme alanine-glyoxylate aminotransferase (AGT). This leads to increased production of oxalate, which cannot be effectively eliminated from the body, resulting in its accumulation primarily in the kidneys and other organs. Subjects and Methods: This study included 17 PH1 Egyptian patients from 12 unrelated families, recruited from the Inherited Kidney Disease Outpatient Clinic and the Dialysis Units, Cairo University Hospitals, during the period from January 2018 to December 2019, aiming to identify the pathogenic variants in the AGXT gene...
April 2024: Genetic Testing and Molecular Biomarkers
#27
JOURNAL ARTICLE
Danzhou Fang, Zhiming Zhou, Yalan Xiong, Yongzeng Fan, Yixuan Li, Huayi Zhao, Jiahui Huang, Gengbiao Yuan, Maohua Rao
OBJECTIVE: Alzheimer's disease, an irreversible neurological condition, demands timely diagnosis for effective clinical intervention. This study employs radiomics analysis to assess image features in default mode network cerebral perfusion imaging among individuals with cognitive impairment. METHODS: A radiomics analysis of cerebral perfusion imaging was conducted on 117 patients with cognitive impairment. They were divided into training and validation sets in a 7:3 ratio...
April 24, 2024: Journal of Applied Clinical Medical Physics
#28
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
#29
JOURNAL ARTICLE
Yamin Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu
The S-phase checkpoint involving CHK1 is essential for fork stability in response to fork stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation. However, it is unclear how the activity of PARP1 is regulated. Here, we found that UFMylation is required for the efficient activation of CHK1 by UFMylating PARP1 at K548 during replication stress. Inactivation of UFL1, the E3 enzyme essential for UFMylation, delayed CHK1 activation and inhibits nascent DNA degradation during replication blockage as seen in PARP1-deficient cells...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#30
JOURNAL ARTICLE
Konstantinos Feidantsis, Nikolas Panteli, Thomas Bousdras, Francesco Gai, Laura Gasco, Efthimia Antonopoulou
In the context of evaluating the impact of environmentally friendly and sustainably produced alternative protein sources in fish feed, the present study's aim was to examine the overall physiological stress response in one of the main fish species of European freshwater aquaculture, Oncorhynchus mykiss (rainbow trout), following the partial substitution of fish meal (FM) with a Tenebrio molitor (TM) (yellow mealworm) full-fat meal. In total, 222 rainbow trout individuals (115.2 ± 14.2 g) were allocated randomly into six tanks, three per dietary treatment, and were fed a formulated diet containing 60% yellow mealworm (TM60) compared to a control diet without insect meal (TM0)...
April 24, 2024: Journal of Animal Physiology and Animal Nutrition
#31
JOURNAL ARTICLE
Diana M Achury-Saldaña, Rafael A Gonzalez, Angel Garcia, Alejandro Mariño, Wilson R Bohorquez
Episodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readmissions and deaths for heart failure between both groups...
April 24, 2024: Computers, Informatics, Nursing: CIN
#32
COMPARATIVE STUDY
Brendan J Cronin, Justine C Lee
No abstract text is available yet for this article.
May 1, 2024: Plastic and Reconstructive Surgery
#33
REVIEW
Yang Song, Longtianyang Lei, Xingyu Cai, Hua Wei, Cui-Yun Yu
Peptides exhibit various biological activities, including biorecognition, cell targeting, and tumor penetration, and can stimulate immune cells to elicit immune responses for tumor immunotherapy. Peptide self-assemblies and peptide-functionalized nanocarriers can reduce the effect of various biological barriers and the degradation by peptidases, enhancing the efficiency of peptide delivery and improving anti-tumor immune responses. To date, the design and development of peptides with various functionalities have been extensively reviewed for enhanced chemotherapy; however, peptide-mediated tumor immunotherapy using peptides acting on different immune cells, to the knowledge, has not yet been summarized...
April 24, 2024: Advanced Healthcare Materials
#34
JOURNAL ARTICLE
Lilah Khoja, Yuting Wang, Syed Emdadul Haque, Habibul Ahsan, Tariqul Islam, Saif Ullah Munshi, A K M Rabiul Hasan, Md Tariqul Islam, Alaya Begum Jharna, Celeste Leigh Pearce
Human Papillomavirus (HPV) self-sampling has been implemented successfully as an alternative to traditional forms of cervical cancer screening in low-resource settings. Through Bangladesh's current national cervical cancer screening program, only about 10% of the at-risk population is reached. Thus, Bangladesh is an ideal setting to consider HPV self-sampling to improve cervical cancer prevention efforts. However, the feasibility and acceptability of HPV self-sampling has not been evaluated in Bangladesh. We aimed to understand levels of HPV and cervical cancer knowledge and to evaluate the feasibility and acceptability of HPV self-sampling for cervical cancer screening in a semi-urban Bangladeshi community...
2024: PLOS Glob Public Health
#35
JOURNAL ARTICLE
J Denise Power, Flaviu Trifoi, Mayilee Canizares, Anthony V Perruccio, Ajaykumar Shanmugaraj, Rajiv Gandhi, J Roderick Davey, Khalid Syed, Nizar N Mahomed, Christian Veillette, Y Raja Rampersaud
OBJECTIVE: To assess the impact of diabetes on physical and mental health status, as well as patient satisfaction, one-year following knee and hip total joint arthroplasty (TJA) for osteoarthritis (OA). METHODS: Participants were 626 hip and 754 knee TJA patients. Pre-surgery data were collected on socio-demographics and health status. The 12-item Short Form Health Survey (SF-12) was collected pre- and one year post-surgery, and physical (PCS) and mental component (MCS) summary scores computed...
2024: PloS One
#36
JOURNAL ARTICLE
Moezedin Javad Rafiee, Matthias G Friedrich
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated with higher mortality in hospitalized severe COVID-19 patients (75.8% versus 9.7%). Cardiovascular Magnetic Resonance (CMR) has emerged as a crucial tool in diagnosing both ischemic and non-ischemic myocardial injuries, providing detailed insights into the impact of COVID-19 on myocardial tissue and function...
April 24, 2024: British Journal of Radiology
#37
JOURNAL ARTICLE
Maya Spaur, Marta Galvez-Fernandez, Qixuan Chen, Melissa A Lombard, Benjamin C Bostick, Pam Factor-Litvak, Amanda M Fretts, Steven J Shea, Ana Navas-Acien, Anne E Nigra
OBJECTIVE: We examined the association of arsenic in federally regulated community water systems (CWSs) and unregulated private wells with type 2 diabetes (T2D) incidence in the Strong Heart Family Study (SHFS), a prospective study of American Indian communities, and the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective study of racially and ethnically diverse urban U.S. communities. RESEARCH DESIGN AND METHODS: We evaluated 1,791 participants from SHFS and 5,777 participants from MESA who had water arsenic estimates available and were free of T2D at baseline (2001-2003 and 2000-2002, respectively)...
April 24, 2024: Diabetes Care
#38
JOURNAL ARTICLE
Idah Mokhele, Tembeka Sineke, Marnie Vujovic, Robert A C Ruiter, Jacqui Miot, Dorina Onoya
We developed a motivational interviewing (MI) counselling training and support program for lay counsellors in South Africa-branded "Thusa-Thuso-helping you help", commonly referred to as Thusa-Thuso. We present the results of a pilot study to determine the program's impact on MI technical skills and qualitatively assess the feasibility of a training-of-trainers (TOT) scale-up strategy among counselling staff of non-governmental (NGO) support partners of the human immunodeficiency virus (HIV) treatment program in South Africa...
2024: PLOS Glob Public Health
#39
JOURNAL ARTICLE
Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BACKGROUND: Worksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. METHODS: In this one-arm pre-post intervention study, we recruited 277 non-pregnant hospital employees aged 18-60 with prediabetes or pre-hypertension...
2024: PloS One
#40
JOURNAL ARTICLE
Salome Kristensen, Kirsten Duch, Bolette Soussi, Constance Jensina de Saint-Aubain, Monika Laugesen, Lene Dreyer
OBJECTIVE: Excess mortality has been demonstrated in patients with systemic lupus erythematosus (SLE) compared with the general population. We aimed to investigate the 5-year and 10-year all-cause mortality in patients with SLE compared with the general population in recent decades. METHODS: Nationwide population-based exposure matched cohort study. Incident cases of SLE diagnosed between 1996 and 2015 were identified using administrative health registries and followed until 2020, allowing for 5 and 10 years of follow-up...
April 24, 2024: Rheumatology
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