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https://www.readbyqxmd.com/read/28342951/a-model-to-identify-individuals-at-high-risk-for-esophageal-squamous-cell-carcinoma-and-precancerous-lesions-in-regions-of-high-prevalence-in-china
#1
Mengfei Liu, Zhen Liu, Hong Cai, Chuanhai Guo, Xiang Li, Chaoting Zhang, Hui Wang, Dong Hang, Fangfang Liu, Qiuju Deng, Xin Yang, Wenqing Yuan, Yaqi Pan, Jingjing Li, Chanyuan Zhang, Na Shen, Zhonghu He, Yang Ke
BACKGROUND & AIMS: We aimed to develop a population-based model to identify individuals at high-risk for esophageal squamous cell carcinoma (ESCC) in regions of China with a high prevalence of this cancer. METHODS: We collected findings from 15,073 permanent residents (45-69 years old) of 334 randomly selected villages in Hua County, Henan Province, China who underwent endoscopic screening (with iodine staining) for ESCC from January 2012 through September 2015...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28342633/pca3-as-a-second-line-biomarker-in-a-prospective-controlled-randomized-opportunistic-prostate-cancer-screening-programme
#2
J Rubio-Briones, J Casanova, F Martínez, J L Domínguez-Escrig, A Fernández-Serra, R Dumont, M Ramírez-Backhaus, A Gómez-Ferrer, A Collado, L Rubio, A Molina, M Vanaclocha, D Sala, J A Lopez-Guerrero
OBJECTIVES: PCA3 performance as a single second line biomarker is compared to the European Randomised Study of Screening for Prostate Cancer risk calculator model 3 (ERSPC RC-3) in an opportunistic screening in prostate cancer (PCa). MATERIAL AND METHODS: 5,199 men, aged 40-75y, underwent prostate-specific antigen (PSA) screening and digital rectal examination (DRE). Men with a normal DRE and PSA ≥3ng/ml had a PCA3 test done. All men with PCA3 ≥35 underwent an initial biopsy (IBx) -12 cores-...
March 22, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28341576/effectiveness-of-interventions-to-reduce-household-air-pollution-and-or-improve-health-in-homes-using-solid-fuel-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#3
REVIEW
Reginald Quansah, Sean Semple, Caroline A Ochieng, Sanjar Juvekar, Frederick Ato Armah, Isaac Luginaah, Jacques Emina
BACKGROUND: Cookstove intervention programs have been increasing over the past two (2) decades in Low and Middle Income Countries (LMICs) across the globe. However, there remains uncertainty regarding the effects of these interventions on household air pollution concentrations, personal exposure concentrations and health outcomes. OBJECTIVES: The primary objective was to determine if household air pollution (HAP) interventions were associated with improved indoor air quality (IAQ) in households in LMICs...
March 21, 2017: Environment International
https://www.readbyqxmd.com/read/28339098/quality-of-life-with-cediranib-in-relapsed-ovarian-cancer-the-icon6-phase-3-randomized-clinical-trial
#4
Dan P Stark, Adrian Cook, Julia M Brown, Michael D Brundage, Andrew C Embleton, Richard S Kaplan, Fharat A Raja, Ann Marie W Swart, Galina Velikova, Wendi Qian, Jonathan A Ledermann
BACKGROUND: The ICON6 trial showed that cediranib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, improved clinical outcomes for patients with platinum-sensitive relapsed ovarian cancer when it was used with chemotherapy and was continued as maintenance therapy. This study describes health-related quality of life (QOL) during the first year of treatment. METHODS: Four hundred fifty-six women were randomly allocated to receive standard chemotherapy only, chemotherapy with concurrent cediranib, or chemotherapy with cediranib administered concurrently and continued as maintenance...
March 24, 2017: Cancer
https://www.readbyqxmd.com/read/28334661/extended-release-naltrexone-reduces-alcohol-consumption-among-released-prisoners-with-hiv-disease-as-they-transition-to-the-community
#5
Sandra A Springer, Angela Di Paola, Marwan M Azar, Russell Barbour, Archana Krishnan, Frederick L Altice
BACKGROUND: Alcohol use disorders (AUDs) are highly prevalent among persons living with HIV (PLH) within the criminal justice system (CJS). Extended-release naltrexone (XR-NTX) has not been previously evaluated among CJS-involved PLH with AUDs. METHODS: A randomized, double-blind, placebo-controlled trial was conducted among 100 HIV+ prisoners with AUDs. Participants were randomized 2:1 to receive 6 monthly injections of XR-NTX or placebo starting one week prior to release...
March 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28330831/the-efficacy-of-internet-based-mindfulness-training-and-cognitive-behavioral-training-with-telephone-support-in-the-enhancement-of-mental-health-among-college-students-and-young-working-adults-randomized-controlled-trial
#6
Winnie Ws Mak, Floria Hn Chio, Amy Ty Chan, Wacy Ws Lui, Ellery Ky Wu
BACKGROUND: College students and working adults are particularly vulnerable to stress and other mental health problems, and mental health promotion and prevention are needed to promote their mental health. In recent decades, mindfulness-based training has demonstrated to be efficacious in treating physical and psychological conditions. OBJECTIVE: The aim of our study was to examine the efficacy of an Internet-based mindfulness training program (iMIND) in comparison with the well-established Internet-based cognitive-behavioral training program (iCBT) in promoting mental health among college students and young working adults...
March 22, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28329243/the-impact-of-medication-adherence-on-virologic-failure-in-a5202-a-randomized-partially-blinded-phase-3b-study
#7
Robert A Parker, Dustin J Rabideau, Paul E Sax, Camlin Tierney, Eric S Daar, Ann C Collier, Elena Losina, Kenneth A Freedberg
In ACTG A5202, participants reporting missing their medication within the past month or not providing adherence reports at both 8 and 24 weeks had five times the hazard of virological failure compared to more adherent participants. Adherence interventions should focus on such patients.
March 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28327263/pit-and-fissure-sealant-retention-following-air-abrasion-preparation-with-bioactive-glass-and-aluminum-oxide-particles
#8
Maryam Khoroushi, Alireza Eshghi, Fatemeh Naderibeni
PURPOSE: Alumina air abrasion is an alternative for acid-etch technique for tooth preparation before placement of a fissure sealant. The aim of this study was to compare the retention of sealants placed subsequent to air abrasion with alumina and bioactive glass (BAG) particles. METHODS: Sixty-two 6-12 year old children were included in this study. Using a halfmouth design, the fissures were prepared using air abrasion with alumina particles on randomly assigned permanent mandibular or/and maxillary first molars on one side of the mouth (Group 1) and air abrasion with BAG on the contralateral side of the mouth (Group 2)...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28319460/power-and-sample-size-for-the-s-t-repeated-measures-design-combined-with-a-linear-mixed-effects-model-allowing-for-missing-data
#9
Toshiro Tango
Tango (Biostatistics 2016) proposed a new repeated measures design called the S:T repeated measures design, combined with generalized linear mixed-effects models and sample size calculations for a test of the average treatment effect that depend not only on the number of subjects but on the number of repeated measures before and after randomization per subject used for analysis. The main advantages of the proposed design combined with the generalized linear mixed-effects models are (1) it can easily handle missing data by applying the likelihood-based ignorable analyses under the missing at random assumption and (2) it may lead to a reduction in sample size compared with the simple pre-post design...
February 13, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28315607/correcting-bias-due-to-missing-stage-data-in-the-non-parametric-estimation-of-stage-specific-net-survival-for-colorectal-cancer-using-multiple-imputation
#10
Milena Falcaro, James R Carpenter
BACKGROUND: Population-based net survival by tumour stage at diagnosis is a key measure in cancer surveillance. Unfortunately, data on tumour stage are often missing for a non-negligible proportion of patients and the mechanism giving rise to the missingness is usually anything but completely at random. In this setting, restricting analysis to the subset of complete records gives typically biased results. Multiple imputation is a promising practical approach to the issues raised by the missing data, but its use in conjunction with the Pohar-Perme method for estimating net survival has not been formally evaluated...
March 15, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28315579/longitudinal-association-between-self-injurious-thoughts-and-behaviors-and-suicidal-behavior-in-adolescents-and-young-adults-a-systematic-review-with-meta-analysis
#11
REVIEW
P Castellví, E Lucas-Romero, A Miranda-Mendizábal, O Parés-Badell, J Almenara, I Alonso, M J Blasco, A Cebrià, A Gabilondo, M Gili, C Lagares, J A Piqueras, M Roca, J Rodríguez-Marín, T Rodríguez-Jimenez, V Soto-Sanz, J Alonso
BACKGROUND: Adolescents with previous self-injurious thoughts and behaviors (SITB) have over 2-fold risk of dying by suicide, higher than older ages. This meta-analysis aims to disentangle the association of each SITB with subsequent suicidal behavior in adolescence/young adulthood, the contribution of each SITB, and the proportion of suicide deaths with no previous suicide attempt. METHODS: We searched 6 databases until June 2015. INCLUSION CRITERIA: 1...
March 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28301676/deprescribing-versus-continuation-of-chronic-proton-pump-inhibitor-use-in-adults
#12
REVIEW
Taline A Boghossian, Farah Joy Rashid, Wade Thompson, Vivian Welch, Paul Moayyedi, Carlos Rojas-Fernandez, Kevin Pottie, Barbara Farrell
BACKGROUND: Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory conditions (e.g. Zollinger-Ellison syndrome), and as part of the eradication therapy for Helicobacter pylori bacteria. However, approximately 25% to 70% of people are prescribed a PPI inappropriately. Chronic PPI use without reassessment contributes to polypharmacy and puts people at risk of experiencing drug interactions and adverse events (e...
March 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28298021/prophylactic-nimodipine-treatment-and-improvement-in-hearing-outcome-after-vestibular-schwannoma-surgery-a-combined-analysis-of-a-randomized-multicenter-phase-iii-trial-and-its-pilot-study
#13
Christian Scheller, Andreas Wienke, Marcos Tatagiba, Alireza Gharabaghi, Kristofer F Ramina, Oliver Ganslandt, Barbara Bischoff, Johannes Zenk, Tobias Engelhorn, Cordula Matthies, Thomas Westermaier, Gregor Antoniadis, Maria Teresa Pedro, Veit Rohde, Kajetan von Eckardstein, Thomas Kretschmer, Malte Kornhuber, Jörg Steighardt, Michael Richter, Fred G Barker, Christian Strauss
OBJECT In clinical routines, neuroprotective strategies in neurosurgical interventions are still missing. A pilot study (n = 30) and an analogously performed Phase III trial (n = 112) pointed to a beneficial effect of prophylactic nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery. Considering the small sample size, the data from both studies were pooled. METHODS The patients in both investigator-initiated studies were assigned to 2 groups. The treatment group (n = 70) received parenteral nimodipine (1-2 mg/hour) and HES (hematocrit 30%-35%) from the day before surgery until the 7th postoperative day...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28296257/randomized-controlled-trial-of-rituximab-and-cost-effectiveness-analysis-in-treating-fatigue-and-oral-dryness-in-primary-sjogren-s-syndrome
#14
Simon J Bowman, Colin C Everett, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Nagui St Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Catherine Reynolds, Claire T Hulme, Kevin A Davies, Christopher J Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Ian P Giles, Linda D Sharples, Michele Bombardieri
OBJECTIVE: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjögren's Syndrome (PSS). METHODS: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo IV or rituximab IV (1000mg in 250mL) at weeks 0, 2, 24 and 26, with pre-and post-infusion medication including corticosteroids...
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28293159/intensified-tuberculosis-case-finding-implementation-of-isoniazid-preventive-therapy-and-associated-factors-among-people-living-with-human-immunodeficiency-virus-at-public-health-facilities-of-harari-region-eastern-ethiopia-a-cross-sectional-study
#15
Ayele Geleto, Degu Abate, Gudina Egata
OBJECTIVE: Globally, the number of people living with human immunodeficiency virus (PLHIV) particularly in sub-Saharan Africa is growing. This has been resulted in increased number of tuberculosis (TB) new cases. To control burden of TB among PLHIV, a number of collaborative TB/HIV activities were recommended. However, data about collaborative TB/HIV services in the study area is scarce. The objective of this study is to assess intensified TB case finding, implementation of isoniazid preventive therapy (IPT) and associated factors among PLHIV...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28291858/alveolar-ridge-dimension-6-months-after-implant-placement-with-simultaneous-hard-tissue-augmentation
#16
Siegfried Martin Heckmann, Barbara Mörtlbauer, Dominik Rieder, Manfred Wichmann, Tim Krafft, Antonios Moralis
PURPOSE: When failing front teeth are replaced by implants, vestibular bone deficiencies frequently require augmentation, even though the amount of missing alveolar volume may vary. The objective of this study was to analyze the horizontal alveolar ridge dimension after implant placement and simultaneous augmentation, and to compare it to the condition at the contralateral natural site. MATERIALS AND METHODS: Forty-eight patients with a failing maxillary incisor received an immediate or early implant (Straumann Bone Level), according to a randomized study protocol...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28288609/social-exclusion-index-for-health-surveys-sei-hs-a-prospective-nationwide-study-to-extend-and-validate-a-multidimensional-social-exclusion-questionnaire
#17
Addi P L van Bergen, Stella J M Hoff, Hanneke Schreurs, Annelies van Loon, Albert M van Hemert
BACKGROUND: Social exclusion (SE) refers to the inability of certain groups or individuals to fully participate in society. SE is associated with socioeconomic inequalities in health, and its measurement in routine public health monitoring is considered key to designing effective health policies. In an earlier retrospective analysis we demonstrated that in all four major Dutch cities, SE could largely be measured with existing local public health monitoring data. The current prospective study is aimed at constructing and validating an extended national measure for SE that optimally employs available items...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28285983/assessing-misclassification-of-vaccination-status-implications-for-studies-of-the-safety-of-the-childhood-immunization-schedule
#18
Matthew F Daley, Jason M Glanz, Sophia R Newcomer, Michael L Jackson, Holly C Groom, Marlene M Lugg, Huong Q McLean, Nicola P Klein, Eric S Weintraub, Michael M McNeil
BACKGROUND: To address public concern about the safety of the childhood immunization schedule, the Institute of Medicine recommended observational studies comparing adverse health outcomes of fully vaccinated children to children under-vaccinated due to parental choice. Misclassification of vaccination status could bias such studies. OBJECTIVE: To assess risk of misclassification of vaccination status within the Vaccine Safety Datalink (VSD). DESIGN/METHODS: A retrospective cohort study was conducted in three phases...
March 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28285479/effectiveness-of-pulse-oximetry-versus-doppler-for-tourniquet-monitoring
#19
Piper L Wall, Charisse M Buising, Lisa Grulke, Alexander Troester, Nicholas Bianchina, Shannon White, Rosemarie Freymark, Ali Hassan, James W Hopkins, Catherine Hackett Renner, Sheryl M Sahr
BACKGROUND: Pulse oximeters are common and include arterial pulse detection as part of their methodology. The authors investigated the possible usefulness of pulse oximeters for monitoring extremity tourniquet arterial occlusion. METHODS: Tactical Ratcheting Medical Tourniquets were tightened to the least Doppler-determined occluding pressure at mid-thigh or mid-arm locations on one limb at a time on all four limbs of 15 volunteers. A randomized block design was used to determine the placement locations of three pulse oximeter sensors on the relevant digits...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28284834/the-effectiveness-of-active-cycling-in-subacute-stroke-rehabilitation-a-randomized-controlled-trial
#20
Christel Vanroy, Hilde Feys, Anke Swinnen, Yves Vanlandewijck, Steven Truijen, Dirk Vissers, Marc Michielsen, Kristien Wouters, Patrick Cras
OBJECTIVE: To examine the effects of 3-month aerobic training (AT) followed by coaching on aerobic capacity, strength and gait speed after subacute stroke. DESIGN: Randomized controlled trial SETTING: Inpatient rehabilitation center PARTICIPANTS: Patients (N=59; mean age= 65.4±10.3; 21 women (36%); Barthel Index≤50= 64%) with first stroke and able to cycle at 50 revolutions/minute enrolled in the study 3-10 weeks after stroke onset. INTERVENTIONS: Patients were randomly allocated to a 3-month cycling group (ACG, n=33) and education or to a control group (CG, n=26)...
March 8, 2017: Archives of Physical Medicine and Rehabilitation
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