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https://www.readbyqxmd.com/read/28454304/cisplatin-plus-vinorelbine-as-induction-treatment-in-stage-iiia-non-small-cell-lung-cancer
#1
Magda Palka, Antonio Sanchez, Mar Córdoba, Gema Díaz Nuevo, Andrés Varela De Ugarte, Blanca Cantos, Miriam Méndez, Virginia Calvo, Constanza Maximiano, Mariano Provencio
Survival rates in patients with stage IIIA non-small cell lung cancer (NSCLC) remain low despite curative treatment. This is due to tumor recurrence at distant sites. The aim of neoadjuvant chemotherapy (NA-CT) is to eradicate occult micrometastatic disease and improve survival in patients that are not candidates for surgery following induction therapy. A total of 21 patients with ipsilateral mediastinal node involvement (N2) with potentially resectable disease, who had been diagnosed with stage IIIA (T1-3 N1-2 and T4N0) NSCLC and who had received cisplatin and vinorelbine as induction treatment were included in this retrospective study...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453834/overproduction-of-outer-membrane-protein-a-by-acinetobacter-baumannii-as-a-risk-factor-for-nosocomial-pneumonia-bacteremia-and-mortality-rate-increase
#2
Viviana Sánchez-Encinales, Rocío Álvarez-Marín, María Eugenia Pachón-Ibáñez, Felipe Fernández-Cuenca, Alvaro Pascual, José Garnacho-Montero, Luis Martínez-Martínez, Jordi Vila, María Mar Tomás, José Miguel Cisneros, Germán Bou, Jesús Rodríguez-Baño, Jerónimo Pachón, Younes Smani
Background.: Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. Methods.: We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28448137/profiling-the-phenolic-compounds-of-the-four-major-seed-coat-types-and-their-relation-to-color-genes-in-lentil
#3
Mahla Mirali, Randy W Purves, Albert Vandenberg
Phenolic compounds can provide antioxidant health benefits for humans, and foods such as lentils can be valuable dietary sources of different subclasses of these secondary metabolites. This study used LC-MS analyses to compare the phenolic profiles of lentil genotypes with four seed coat background colors (green, gray, tan, and brown) and two cotyledon colors (red and yellow) grown at two locations. The mean area ratio per mg sample (MARS) values of various phenolic compounds in lentil seeds varied with the different seed coat colors conferred by specific genotypes...
April 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28447824/correction-to-kuhn-et-al-2017
#4
(no author information available yet)
Reports an error in "Similar Representations of Emotions Across Faces and Voices" by Lisa Katharina Kuhn, Taeko Wydell, Nadine Lavan, Carolyn McGettigan and Lúcia Garrido (Emotion, Advanced Online Publication, Mar 02, 2017, np). (The following abstract of the original article appeared in record 2017-09406-001.) Emotions are a vital component of social communication, carried across a range of modalities and via different perceptual signals such as specific muscle contractions in the face and in the upper respiratory system...
April 27, 2017: Emotion
https://www.readbyqxmd.com/read/28447482/quantitative-potassium-measurements-with-laser-induced-breakdown-spectroscopy-using-low-energy-lasers-application-to-in-situ-k-ar-geochronology-for-planetary-exploration
#5
Yuichiro Cho, Misa Horiuchi, Kazuo Shibasaki, Shingo Kameda, Seiji Sugita
In situ radiogenic isotope measurements to obtain the absolute age of geologic events on planets are of great scientific value. In particular, K-Ar isochrons are useful because of their relatively high technical readiness and high accuracy. Because this isochron method involves spot-by-spot K measurements using laser-induced breakdown spectroscopy (LIBS) and simultaneous Ar measurements with mass spectrometry, LIBS measurements are conducted under a high vacuum condition in which emission intensity decreases significantly...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28447104/bmp-type-ii-receptor-as-a-therapeutic-target-in-pulmonary-arterial-hypertension
#6
REVIEW
Mar Orriols, Maria Catalina Gomez-Puerto, Peter Ten Dijke
Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of small peripheral lung vasculature resulting in progressive occlusion of the artery lumen that eventually causes right heart failure and death. The most common cause of PAH is inactivating mutations in the gene encoding a bone morphogenetic protein type II receptor (BMPRII). Current therapeutic options for PAH are limited and focused mainly on reversal of pulmonary vasoconstriction and proliferation of vascular cells...
April 26, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28446424/hormone-supplementation-for-pubertal-induction-in-girls
#7
REVIEW
Debbie Matthews, Louise Bath, Wolfgang Högler, Avril Mason, Arlene Smyth, Mars Skae
Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly complex process. Here we amalgamate the sparse global evidence and propose three options for pubertal induction regimens including oral ethinyloestradiol, and oral and transdermal 17β-oestradiol. The introduction of progestogens is discussed and the transition to hormone supplementation for adult women. The merits and disadvantages of the different options are detailed. The available evidence indicates that transdermal 17β-oestradiol has the most favourable efficacy, safety and cost profile but randomised controlled trials are urgently required to determine which regimen provides the best clinical outcomes...
April 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28445871/three-year-clinical-outcome-of-patients-with-coronary-disease-and-increased-event-risk-treated-with-newer-generation-drug-eluting-stents-from-the-randomized-dutch-peers-trial
#8
Liefke C van der Heijden, Marlies M Kok, Marije M Löwik, Peter W Danse, Gillian A J Jessurun, Marc Hartmann, Martin G Stoel, K Gert van Houwelingen, Raymond W M Hautvast, Gerard C Linssen, Carine J M Doggen, Clemens von Birgelen
OBJECTIVE: Limited data is available on the long-term outcome of patients with increased cardiovascular event risk, treated with newer-generation durable polymer drug-eluting stents (DES). METHODS: We therefore assessed 3-year follow-up data of high-risk versus low- to intermediate-risk patients of the randomized DUTCH PEERS trial (NCT01331707). In both risk groups we also compared patients treated with Resolute Integrity versus Promus Element DES. Patients were categorized as "high-risk" if they met ≥1 of the following criteria: (1) diabetes (17...
April 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28445264/incremental-cost-of-nosocomial-bacteremia-according-to-the-focus-of-infection-and-antibiotic-sensitivity-of-the-causative-microorganism-in-a-university-hospital
#9
Marta Riu, Pietro Chiarello, Roser Terradas, Maria Sala, Enric Garcia-Alzorriz, Xavier Castells, Santiago Grau, Francesc Cots
To estimate the incremental cost of nosocomial bacteremia according to the causative focus and classified by the antibiotic sensitivity of the microorganism.Patients admitted to Hospital del Mar in Barcelona from 2005 to 2012 were included. We analyzed the total hospital costs of patients with nosocomial bacteremia caused by microorganisms with a high prevalence and, often, with multidrug-resistance. A control group was defined by selecting patients without bacteremia in the same diagnosis-related group.Our hospital has a cost accounting system (full-costing) that uses activity-based criteria to estimate per-patient costs...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445165/non-diverging-analytical-expression-for-the-sensitivity-of-converging-spect-collimators
#10
Jarno van Roosmalen, Marlies C Goorden
Accurate analytical expressions for collimator resolution and sensitivity are important tools in the optimization of SPECT systems. However, presently known expressions for the sensitivity of converging collimators either diverge near the focal point or focal line(s), or are only valid on the collimator axis. As a result, these expressions are unsuitable to calculate volumetric sensitivity for e.g. short-focal length collimators that focus inside the object to enhance sensitivity. To also enable collimator optimization for these geometries, we here present non-diverging sensitivity formulas for astigmatic, cone beam and fan beam collimators that are applicable over the full collimator's field-of-view...
April 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28445084/brain-atrophy-15-years-after-cis-baseline-and-follow-up-clinico-radiological-correlations
#11
Angela Vidal-Jordana, Jaume Sastre-Garriga, Deborah Pareto, Carmen Tur, Georgina Arrambide, Susana Otero-Romero, Elena Huerga, Raquel Mitjana, Cristina Auger, Mar Tintoré, Alex Rovira, Xavier Montalban
BACKGROUND: Brain atrophy in multiple sclerosis (MS) patients is present since the very early stages of the disease and it has been related to long-term disability. OBJECTIVE: To estimate brain volume (BV) at 15 years after a clinically isolated syndrome (CIS) and to evaluate its relationship with disease outcomes. METHODS: From a prospective cohort including patients presenting with a CIS, 54 patients with a brain magnetic resonance imaging (MRI) performed 15 years after CIS were included...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28444974/school-based-surveillance-for-influenza-vaccine-effectiveness-during-2014-15-seasons-in-hong-kong
#12
Ting F Leung, Renee W Y Chan, Angela Kwok, Wendy C S Ho, Mars K P Tao, Kam L Hon, Frankie W T Cheng, Albert M Li, Paul K S Chan
BACKGROUND: Influenza imposes substantial healthcare burden in children, which can be prevented by vaccination. Influenza vaccination coverage varies widely among childhood populations worldwide, which has significant impact on herd immunity and usefulness of influenza vaccine. However, there is limited real-life data on influenza vaccine effectiveness (VE) in children. OBJECTIVE: This prospective study aimed to investigate clinical spectrum of childhood influenza and VE in preventing influenza in Hong Kong children...
April 26, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28444409/diagnostic-work-up-and-specific-causes-of-acute-kidney-injury
#13
REVIEW
Michael Darmon, Marlies Ostermann, Jorge Cerda, Meletios A Dimopoulos, Lui Forni, Eric Hoste, Matthieu Legrand, Nicolas Lerolle, Eric Rondeau, Antoine Schneider, Bertrand Souweine, Miet Schetz
Acute kidney injury (AKI) is common in critically ill patients and associated with grim short- and long-term outcome. Although in the vast majority of cases AKI is multifactorial, with sepsis, shock and nephrotoxicity accounting for most episodes, specific causes of AKI are not uncommon. Despite remaining uncertainties regarding their prevalence in the ICU, prompt recognition of specific aetiologies of AKI is likely to ensure timely management, limit worsening of renal dysfunction, and ultimately limit renal and systemic consequences of AKI...
April 25, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28444046/health-care-networks-implementation-and-regional-governance-challenges-in-the-legal-amazon-region-an-analysis-of-the-qualisus-rede-project
#14
Angela Oliveira Casanova, Marly Marques Cruz, Ligia Giovanella, Glaydes Dos Reis Alves, Gisela Cordeiro Pereira Cardoso
This paper aims to analyze the potential, limits and challenges of regional governance in the implementation process of health care networks in three Brazilian regions: Alto Solimões (Amazonas), Belém (Pará) and an interstate region comprising Tocantins, Pará and Maranhão states (Topama). The study is based on the evaluation study on the implementation of the Quality Health Care Network Development and Improvement Project (QualiSUS-Rede). This is a qualitative multiple case study with the analysis of official documents and use of semi-structured interviews with key stakeholders conducted from July to December 2014...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444009/-antituberculosis-drug-resistance-in-the-border-of-brazil-with-paraguay-and-bolivia
#15
Marli Marques, Eunice Atsuko Totumi Cunha, Maria do Socorro Nantua Evangelista, Paulo Cesar Basta, Ana Maria Campos Marques, Julio Croda, Sonia Maria Oliveira de Andrade
Objective: To estimate the rate of drug resistance among pulmonary tuberculosis (PTB) cases in the state of Mato Grosso do Sul, Brazil, and specifically in the border areas with Paraguay and Bolivia, as well as to identify associated risk factors. Method: The present cross-sectional, epidemiological study focused on PTB cases recorded between January 2007 and December 2010 in the State Reportable Disease Information System with results of susceptibility tests to rifampicin, isoniazid, ethambutol, and streptomycin...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28442198/operational-oil-spill-trajectory-modelling-using-hf-radar-currents-a-northwest-european-continental-shelf-case-study
#16
Ana J Abascal, Jorge Sanchez, Helios Chiri, María I Ferrer, Mar Cárdenas, Alejandro Gallego, Sonia Castanedo, Raúl Medina, Andrés Alonso-Martirena, Barbara Berx, William R Turrell, Sarah L Hughes
This paper presents a novel operational oil spill modelling system based on HF radar currents, implemented in a northwest European shelf sea. The system integrates Open Modal Analysis (OMA), Short Term Prediction algorithms (STPS) and an oil spill model to simulate oil spill trajectories. A set of 18 buoys was used to assess the accuracy of the system for trajectory forecast and to evaluate the benefits of HF radar data compared to the use of currents from a hydrodynamic model (HDM). The results showed that simulated trajectories using OMA currents were more accurate than those obtained using a HDM...
April 22, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28440880/-to-be-forgotten-statements-become-less-true-memory-processes-involved-in-selection-and-forgetting-lead-to-truthfulness-changes-of%C3%A2-ambiguous-sentences
#17
Ana Sofia Santos, Tânia Ramos, Leonel Garcia-Marques, Paula Carneiro
What happens when people try to forget something? What are the consequences of instructing people to intentionally forget a sentence? Recent studies employing the item-method directed forgetting paradigm have shown that to-be-forgotten (TBF) items are, in a subsequent task, emotionally devaluated relative to to-be-remembered (TBR) items, an aftereffect of memory selection (Vivas, Marful, Panagiotidou & Bajo, 2016). As such, distractor devaluation by attentional selection generalizes to memory selection. In this study, we use the item-method directed forgetting paradigm to test the effects of memory selection and inhibition on truth judgments of ambiguous sentences...
April 25, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28440766/unfavorable-cytokine-and-adhesion-molecule-profiles-during-and-after-pregnancy-in-women-with-gestational-diabetes-mellitus
#18
María Del Mar Roca-Rodríguez, Cristina López-Tinoco, Álvaro Fernández-Deudero, Mora Murri, María Victoria García-Palacios, María Del Amor García-Valero, Francisco José Tinahones, Manuel Aguilar-Diosdado
BACKGROUND: Gestational diabetes mellitus is a significant risk factor for metabolic syndrome and cardiovascular disease. AIMS: To assess the relationships between components of the metabolic syndrome and cytokine and adhesion molecule levels in women with GDM during pregnancy and after delivery. PATIENTS AND METHODS: A prospective case-control study on a sample of 126 pregnant women (63 with and 63 without gestational diabetes mellitus). In an intra-subject analysis, 41 women with history of gestational diabetes mellitus and 21 controls were re-assessed in the postpartum period...
January 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28440592/sequential-reactions-of-alkynes-on-an-ir-iii-single-site
#19
Miguel A Sierra, Mar Gómez-Gallego, Luis Casarrubios, Carmen Ramírez de Arellano, Elena A Giner, Alba D Merinero
Sequential insertion of terminal alkynes on Ir(III) cyclometallated complexes allow the formation of novel metallapolycycles in controlled and efficient manner. ortho-Methylarylethynyl derivatives led to an unprecedented cascade combination of three fundamental processes (C-C bond formation, Csp3-H activation and reductive elimination) on a single Ir(III) center, in a process compatible with functionalized biomolecules and photoactive substrates. The reaction with tert-butylacetylene led to a [6,5,4]-polycycle that incorporates an iridacyclobutenylidene in its structure...
April 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28439643/have-renal-biomarkers-failed-in-acute-kidney-injury-yes
#20
Jill Vanmassenhove, Jan T Kielstein, Marlies Ostermann
No abstract text is available yet for this article.
April 24, 2017: Intensive Care Medicine
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