keyword
https://read.qxmd.com/read/38529514/assessment-of-bronchodilator-responsiveness-to-salbutamol-or-ipratropium-using-different-criteria-in-treatment-na%C3%A3-ve-patients-with-asthma-and-copd
#21
JOURNAL ARTICLE
Zsófia Lázár, Alpár Horváth, Szilvia Kiss-Dala, Zsolt Abonyi-Tóth, Balázs Csoma, Katalin Kontz, Lilla Tamási, Veronika Müller
BACKGROUND: The criteria for significant bronchodilator responsiveness (BDR) were published in 2005 by the European Respiratory Society/American Thoracic Society, which were revised in 2021, however, data on the agreement between these two recommendations in untreated patients with airflow limitation are missing. AIMS: We aimed to study BDR to salbutamol (SABA) or ipratropium bromide (SAMA) in patients with suspected bronchial asthma or COPD at initial clinical presentation using the 2005 and 2021 criteria and explore clinical factors associated with BDR+...
2024: European Clinical Respiratory Journal
https://read.qxmd.com/read/38529458/improving-the-quality-of-operative-notes-in-vascular-surgery-a-retrospective-analysis
#22
JOURNAL ARTICLE
Munzir Akasha, Ahmmad Alfatih, Mohamedali Mohamed, Yogesh Acharya, Mahmoud Alawy
Background and objective Missing information or mistakes in patients' medical records, including those related to intraoperative and postoperative information, in an operative note can have profound clinical, ethical, and medicolegal implications. Operative notes should be informative, clear, and inclusive of the necessary data and should be collated immediately following surgery. In this study, we aimed to determine the ways to improve the quality of operative notes in the field of vascular surgery. Methods In this retrospective analysis, we compared the operative notes of 32 patients in the Department of Vascular and Endovascular Surgery, University Hospital Galway, against the standard set by the Royal College of Surgeons in Ireland (RCSI) (Code of Practice for Surgeons RCSI, 2018) and presented the results to our departmental staff...
February 2024: Curēus
https://read.qxmd.com/read/38528593/a-novel-large-intragenic-dpyd-deletion-causing-dihydropyrimidine-dehydrogenase-deficiency-a-case-report
#23
JOURNAL ARTICLE
Anna Malekkou, Marios Tomazou, Gavriella Mavrikiou, Maria Dionysiou, Theodoros Georgiou, Ioannis Papaevripidou, Angelos Alexandrou, Carolina Sismani, Anthi Drousiotou, Olga Grafakou, Petros P Petrou
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD), is the initial and rate-limiting enzyme in the catabolic pathway of pyrimidines. Deleterious variants in the DPYD gene cause DPD deficiency, a rare autosomal recessive disorder. The clinical spectrum of affected individuals is wide ranging from asymptomatic to severely affected patients presenting with intellectual disability, motor retardation, developmental delay and seizures. DPD is also important as the main enzyme in the catabolism of 5-fluorouracil (5-FU) which is extensively used as a chemotherapeutic agent...
March 25, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38528574/acute-exacerbation-of%C3%A2-idiopathic-pulmonary-fibrosis-disease-a-diagnosis-model-in-china
#24
JOURNAL ARTICLE
Liye Meng, Jun Xiao, Li Wang, Zhuochun Huang
OBJECTIVE: To develop and validate a diagnosis model to inform risk stratified decisions for idiopathic pulmonary fibrosis patients experiencing acute exacerbations (AE-IPF). METHODS: In this retrospective cohort study performed from 1 January 2016 to 31 December 2022, we used data from the West China Hospital of Sichuan University for model development and validation. Blood test results and the underlying diseases of patients were collected through the HIS system and LIS system...
March 25, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38527595/boosting-edger-robust-by-dealing-with-missing-observations-and-gene-specific-outliers-in-rna-seq-profiles-and-its-application-to-explore-biomarker-genes-for-diagnosis-and-therapies-of-ovarian-cancer
#25
JOURNAL ARTICLE
Bandhan Sarker, Md Matiur Rahaman, Muhammad Habibulla Alamin, Md Ariful Islam, Md Nurul Haque Mollah
The edgeR (Robust) is a popular approach for identifying differentially expressed genes (DEGs) from RNA-Seq profiles. However, it shows weak performance against gene-specific outliers and is unable to handle missing observations. To address these issues, we proposed a pre-processing approach of RNA-Seq count data by combining the iLOO-based outlier detection and random forest-based missing imputation approach for boosting the performance of edgeR (Robust). Both simulation and real RNA-Seq count data analysis results showed that the proposed edgeR (Robust) outperformed the conventional edgeR (Robust)...
March 23, 2024: Genomics
https://read.qxmd.com/read/38527287/deep-learning-to-estimate-cardiovascular-risk-from-chest-radiographs-a-risk-prediction-study
#26
JOURNAL ARTICLE
Jakob Weiss, Vineet K Raghu, Kaavya Paruchuri, Aniket Zinzuwadia, Pradeep Natarajan, Hugo J W L Aerts, Michael T Lu
BACKGROUND: Guidelines for primary prevention of atherosclerotic cardiovascular disease (ASCVD) recommend a risk calculator (ASCVD risk score) to estimate 10-year risk for major adverse cardiovascular events (MACE). Because the necessary inputs are often missing, complementary approaches for opportunistic risk assessment are desirable. OBJECTIVE: To develop and test a deep-learning model (CXR CVD-Risk) that estimates 10-year risk for MACE from a routine chest radiograph (CXR) and compare its performance with that of the traditional ASCVD risk score for implications for statin eligibility...
March 26, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38527066/enrichment-on-steps-not-genes-improves-inference-of-differentially-expressed-pathways
#27
JOURNAL ARTICLE
Nicholas Markarian, Kimberly M Van Auken, Dustin Ebert, Paul W Sternberg
Enrichment analysis is frequently used in combination with differential expression data to investigate potential commonalities amongst lists of genes and generate hypotheses for further experiments. However, current enrichment analysis approaches on pathways ignore the functional relationships between genes in a pathway, particularly OR logic that occurs when a set of proteins can each individually perform the same step in a pathway. As a result, these approaches miss pathways with large or multiple sets because of an inflation of pathway size (when measured as the total gene count) relative to the number of steps...
March 25, 2024: PLoS Computational Biology
https://read.qxmd.com/read/38527030/clinical-challenges-of-biomechanical-performance-of-narrow-diameter-implants-in-maxillary-posterior-teeth-in-aging-patients-a-finite-element-analysis
#28
JOURNAL ARTICLE
Saranyoo Prasitwuttisak, Nattapon Chantarapanich, Komsan Apinyauppatham, Kopchai Poomparnich, Samroeng Inglam
This study evaluated the biomechanical performance of narrow-diameter implant (NDI) treatment in atrophic maxillary posterior teeth in aging patients by finite element analysis. The upper left posterior bone segment with first and second premolar teeth missing obtained from a patient's cone beam computed tomography data was simulated with cortical bone thicknesses of 0.5 and 1.0 mm. Three model groups were analyzed. The Regimen group had NDIs of 3.3 × 10 mm in length with non-splinted crowns. Experimental-1 group had NDIs of 3...
2024: PloS One
https://read.qxmd.com/read/38526865/provision-of-medications-for-self-managed-abortion-before-and-after-the-dobbs-v-jackson-women-s-health-organization-decision
#29
JOURNAL ARTICLE
Abigail R A Aiken, Elisa S Wells, Rebecca Gomperts, James G Scott
IMPORTANCE: The Supreme Court decision in Dobbs v Jackson Women's Health Organization overturned the right to choose abortion in the US, with at least 16 states subsequently implementing abortion bans or 6-week gestational limits. Prior research indicates that in the 6 months following Dobbs, approximately 32 360 fewer abortions were provided within the US formal health care setting. However, trends in the provision of medications for self-managed abortion outside the formal health care setting have not been studied...
March 25, 2024: JAMA
https://read.qxmd.com/read/38526603/global-longitudinal-strain-in-long-term-risk-prediction-after-acute-coronary-syndrome-an-investigation-of-added-prognostic-value-to-ejection-fraction
#30
JOURNAL ARTICLE
Joel Lenell, Bertil Lindahl, David Erlinge, Tomas Jernberg, Jonas Spaak, Tomasz Baron
AIMS: This study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS). METHOD AND RESULTS: This retrospective study included patients admitted with ACS between 2008 and 2014 from the three participating university hospitals. LVEF and GLS were assessed at a core lab from images acquired during the index hospital stay...
March 25, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38526492/job-flexibility-job-security-and-mental-health-among-us-working-adults
#31
JOURNAL ARTICLE
Monica L Wang, Marie-Rachelle Narcisse, Katherine Togher, Pearl A McElfish
IMPORTANCE: Understanding the association between job characteristics and mental health can inform policies and practices to promote employee well-being. OBJECTIVE: To investigate associations between job characteristics and mental health, work absenteeism, and mental health care use among US adults. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study analyzed data from the 2021 National Health Interview Survey and included adults aged 18 years or older who reported employment during the past 12 months...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38526297/water-hydrocarbon-interactions-in-anionic-pyrene-monohydrate
#32
JOURNAL ARTICLE
Natalie LeMessurier, Heinrich Salzmann, River Leversee, J Mathias Weber, Joel D Eaves
Interactions between water and polycyclic aromatic hydrocarbons are essential in many aspects of chemistry, from interstellar and atmospheric processes to interfacial hydrophobicity and wetting phenomena. Despite their growing importance, the intermolecular potentials of the water-hydrocarbon interactions are underdeveloped compared to the water-water potentials, and there are similarly few experimental probes that are sensitive to the details of the water-hydrocarbon potential. We present a combined experimental and computational study of anionic pyrene monohydrate, one of the simplest water/hydrocarbon clusters...
March 25, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38525938/impact-of-aspirin-use-on-rates-of-metastasis-in-patients-with-esophageal-cancer-insights-from-the-national-inpatient-sample
#33
JOURNAL ARTICLE
Jay Patel, Tejasvini Khanna, Aalam Sohal, Armaan Dhaliwal, Hunza Chaudhry, Shivam Kalra, Ishandeep Singh, Dino Dukovic, Kanwal Bains
Despite advancing treatment methods, esophageal cancer (EC) maintains a high mortality rate and poor prognosis. Through various mechanisms, aspirin has been suggested to have a chemopreventive effect on EC. However, the long-term impact, particularly regarding the rate of metastasis, needs to be further elucidated. NIS 2016-2020 was used to identify adult patients (age > 18 years) with EC using ICD-10 codes. Patients with missing demographics and mortality were excluded. Patients were stratified into two groups based on aspirin use...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525832/readability-analysis-and-concept-mapping-of-proms-used-for-headache-disorders
#34
REVIEW
Merel H J Hazewinkel, Lisa Gfrerer, Sait Ashina, William G Austen, Anne F Klassen, Andrea Pusic, Manraj N Kaur
OBJECTIVE: To assess the readability and the comprehensiveness of patient-reported outcome measures (PROMs) utilized in primary headache disorders literature. BACKGROUND: As the health-care landscape has evolved toward a patient-centric model, numerous PROMs have been developed to capture treatment outcomes in patients with headache disorders. For these PROMs to advance our understanding of headache disorders and their treatment impact, they must be easy to understand (i...
March 25, 2024: Headache
https://read.qxmd.com/read/38525637/progress-towards-90-90-90-and-95-95-95-strategy-implementations-and-hiv-positivity-trends-in-the-city-of-johannesburg
#35
JOURNAL ARTICLE
J C Y Nyasulu, I Maposa
BACKGROUND: The 95-95-95 strategy implementation is a positive initiative for moving the HIV tide towards elimination, with a focus on addressing the huge inequalities in existence in access to HIV services. OBJECTIVES: To establish performance towards the 90-90-90 and 95-95-95 targets and trends in HIV positivity rates since strategy implementation rollout in the City of Johannesburg (CoJ), South Africa. METHODS: This was a descriptive study, part of the bigger quasi-experimental study using the monthly District Health Information System during the implementation and rollout of the 90-90-90 strategy...
December 31, 2023: South African Medical Journal
https://read.qxmd.com/read/38525301/biovdb-biological-vector-database-for-high-throughput-gene-expression-meta-analysis
#36
JOURNAL ARTICLE
Michał J Winnicki, Chase A Brown, Hunter L Porter, Cory B Giles, Jonathan D Wren
High-throughput sequencing has created an exponential increase in the amount of gene expression data, much of which is freely, publicly available in repositories such as NCBI's Gene Expression Omnibus (GEO). Querying this data for patterns such as similarity and distance, however, becomes increasingly challenging as the total amount of data increases. Furthermore, vectorization of the data is commonly required in Artificial Intelligence and Machine Learning (AI/ML) approaches. We present BioVDB, a vector database for storage and analysis of gene expression data, which enhances the potential for integrating biological studies with AI/ML tools...
2024: Frontiers in artificial intelligence
https://read.qxmd.com/read/38525178/patterns-and-predictors-of-tooth-loss-among-partially-dentate-individuals-in-jordan-a-cross-sectional-study
#37
JOURNAL ARTICLE
Anas Alibrahim, Hamza Al Salieti, Mohammad Alrawashdeh, Hisham Darweesh, Hussein Alsaleh
AIM: This study aimed to examine the patterns of partial edentulism and the associated risk factors in Jordan. METHODS: A cross-sectional, epidemiological study was carried out across Jordan, and data was collected from adult partially dentate patients in various healthcare facilities. The data collected included sociodemographic data, dental and social history, and clinical examination findings for the jaw and teeth. Multivariate regression models were used to determine the predictors for the number of missing teeth...
March 2024: Saudi Dental Journal
https://read.qxmd.com/read/38524864/multisite-pain-and-intensity-were-associated-with-history-fall-among-older-adults-a-cross-sectional-study
#38
JOURNAL ARTICLE
Saud M Alrawaili, Khalid M Alkhathami, Mohamed G Elsehrawy, Sakher M Obaidat, Norah A Alhwoaimel, Aqeel M Alenazi
PURPOSE: This study examined the independent associations among multisite pain, pain intensity, and the risk of falls, including a history of falls in the previous 12 months and frequent falls (≥ two falls vs one or two falls) among community-dwelling older adults. METHODS: A cross-sectional design from Wave 2 of the National Social Life, Health, and Aging Project was used. Data on pain intensity and location (45 sites) over the past 4 weeks were collected...
2024: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38524684/ex-situ-conservation-of-two-rare-oak-species-using-microsatellite-and-snp-markers
#39
JOURNAL ARTICLE
Austin C Koontz, Emily K Schumacher, Emma S Spence, Sean M Hoban
Plant collections held by botanic gardens and arboreta are key components of ex situ conservation. Maintaining genetic diversity in such collections allows them to be used as resources for supplementing wild populations. However, most recommended minimum sample sizes for sufficient ex situ genetic diversity are based on microsatellite markers, and it remains unknown whether these sample sizes remain valid in light of more recently developed next-generation sequencing (NGS) approaches. To address this knowledge gap, we examine how ex situ conservation status and sampling recommendations differ when derived from microsatellites and single nucleotide polymorphisms (SNPs) in garden and wild samples of two threatened oak species...
March 2024: Evolutionary Applications
https://read.qxmd.com/read/38524314/corneal-stress-strain-index-in-myopic-indian-population
#40
JOURNAL ARTICLE
Vaishal P Kenia, Raj V Kenia, Pradnya Bendre, Onkar H Pirdankar
AIM: The purpose is to study the corneal stress-strain index (SSI) in myopic refractive error among Indian subjects. METHODS: A retrospective study where young myopic subjects aged between 11 and 35 years who had undergone corneal biomechanics assessment using Corvis ST between January 2017 and December 2021 were enrolled. Subjects with central corneal thickness (CCT) <500 μ, intraocular pressure (IOP) >21 mmHg, history of any systemic and ocular disease or any previous ocular surgery, high astigmatism, corneal disease such as keratoconus were excluded...
2024: Oman Journal of Ophthalmology
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