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https://www.readbyqxmd.com/read/28735111/screening-disrupted-molecular-functions-and-pathways-associated-with-clear-cell-renal-cell-carcinoma-using-gibbs-sampling
#1
Ning Nan, Qi Chen, Yu Wang, Xu Zhai, Chuan-Ce Yang, Bin Cao, Tie Chong
OBJECTIVE: To explore the disturbed molecular functions and pathways in clear cell renal cell carcinoma (ccRCC) using Gibbs sampling. METHODS: Gene expression data of ccRCC samples and adjacent non-tumor renal tissues were recruited from public available database. Then, molecular functions of expression changed genes in ccRCC were classed to Gene Ontology (GO) project, and these molecular functions were converted into Markov chains. Markov chain Monte Carlo (MCMC) algorithm was implemented to perform posterior inference and identify probability distributions of molecular functions in Gibbs sampling...
July 13, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28734929/aripiprazole-prevents-renal-ischemia-reperfusion-injury-in-rats-probably-through-nitric-oxide-involvement
#2
Hanieh Gholampour, Leila Moezi, Hamed Shafaroodi
Renal ischemia/reperfusion (I/R) injury is strongly related to morbidity and mortality. Oxidative stress, inflammation, and apoptosis play key roles in renal dysfunction following renal I/R. Aripiprazole is an atypical antipsychotic which used for the treatment of schizophrenia and bipolar disorder. Recent studies have reported aripiprazole as displaying certain anti-inflammatory effects. Regarding the underlying mechanisms of renal ischemia-reperfusion, therefore, nephroprotective effects might be predicted to be seen with aripiprazole...
July 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28734549/habitual-versus-goal-driven-attention
#3
REVIEW
Yuhong V Jiang
Recent research has expanded the list of factors that control spatial attention. Beside current goals and perceptual salience, statistical learning, reward, motivation and emotion also affect attention. But do these various factors influence spatial attention in the same manner, as suggested by the integrated framework of attention, or do they target different aspects of spatial attention? Here I present evidence that the control of attention may be implemented in two ways. Whereas current goals typically modulate where in space attention is prioritized, search habits affect how one moves attention in space...
July 4, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28731794/a-neutral-model-for-the-evolution-of-diet-breadth
#4
Matthew L Forister, Stephen H Jenkins
Variation in diet breadth among organisms is a pervasive feature of the natural world that has resisted general explanation. In particular, trade-offs in the ability to use one resource at the expense of another have been expected but rarely detected. We explore a spatial model for the evolution of specialization, motivated by studies of plant-feeding insects. The model is neutral with respect to the causes and consequences of diet breadth: the number of hosts utilized is not constrained by trade-offs, and specialization or generalization does not confer a direct advantage with respect to the persistence of populations or the probability of diversification...
August 2017: American Naturalist
https://www.readbyqxmd.com/read/28731691/singlet-oxygen-photophysics-in-liquid-solvents-converging-on-a-unified-picture
#5
Mikkel Bregnhøj, Michael Westberg, Boris F Minaev, Peter R Ogilby
Singlet oxygen, O2(a(1)Δg), the lowest excited electronic state of molecular oxygen, is an omnipresent part of life on earth. It is readily formed through a variety of chemical and photochemical processes, and its unique reactions are important not just as a tool in chemical syntheses but also in processes that range from polymer degradation to signaling in biological cells. For these reasons, O2(a(1)Δg) has been the subject of intense activity in a broad distribution of scientific fields for the past ∼50 years...
July 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28731207/polyclonal-and-monoclonal-antibodies-for-treating-acute-rejection-episodes-in-kidney-transplant-recipients
#6
REVIEW
Angela C Webster, Sunny Wu, Krishna Tallapragada, Min Young Park, Jeremy R Chapman, Sue J Carr
BACKGROUND: Registry data shows that the incidence of acute rejection has been steadily falling. Approximately 10% to 35% of kidney recipients will undergo treatment for at least one episode of acute rejection within the first post-transplant year. Treatment options include pulsed steroid therapy, the use of an antibody preparation, the alteration of background immunosuppression, or combinations of these options. Over recent years, new treatment strategies have evolved, and in many parts of the world there has been an increase in use of tacrolimus and mycophenolate and a reduction in the use of cyclosporin and azathioprine use as baseline immunosuppression to prevent acute rejection...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28730269/emergence-of-candida-glabrata-in-vulvovaginal-candidiasis-should-be-attributed-to-selective-pressure-or-virulence-ability
#7
Sandra Sayuri Nakamura-Vasconcelos, Adriana Fiorini, Pamela Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Janine Ribeiro Godoy, Adriana Araújo Almeida-Apolonio, Marcia Edilaine Lopes Consolaro, Terezinha Inez Estivalet Svidzinski
PURPOSE: Vulvovaginal candidiasis (VVC) is one of the most frequent female genital disorders and Candida glabrata is the second most common agent. Current study was aimed to study the susceptibility to antifungal agents of C. glabrata isolated from vaginal samples and some virulence attributes in order to better understand why this species is emerging as the main VVC agents. METHODS: A total of 60 C. glabrata vaginal isolates were included in this study. Firstly they were screened by susceptibility tests to antifungal agents...
July 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28729899/evolutionary-loss-of-melanogenesis-in-the-tunicate-molgula-occulta
#8
Claudia Racioppi, Maria Carmen Valoroso, Ugo Coppola, Elijah K Lowe, C Titus Brown, Billie J Swalla, Lionel Christiaen, Alberto Stolfi, Filomena Ristoratore
BACKGROUND: Analyzing close species with diverse developmental modes is instrumental for investigating the evolutionary significance of physiological, anatomical and behavioral features at a molecular level. Many examples of trait loss are known in metazoan populations living in dark environments. Tunicates are the closest living relatives of vertebrates and typically present a lifecycle with distinct motile larval and sessile adult stages. The nervous system of the motile larva contains melanized cells associated with geotactic and light-sensing organs...
2017: EvoDevo
https://www.readbyqxmd.com/read/28729822/low-intensity-focused-tdcs-over-the-motor-cortex-shows-inefficacy-to-improve-motor-imagery-performance
#9
Irma N Angulo-Sherman, Marisol Rodríguez-Ugarte, Eduardo Iáñez, Jose M Azorín
Transcranial direct current stimulation (tDCS) is a brain stimulation technique that can enhance motor activity by stimulating the motor path. Thus, tDCS has the potential of improving the performance of brain-computer interfaces during motor neurorehabilitation. tDCS effects depend on several aspects, including the current density, which usually varies between 0.02 and 0.08 mA/cm(2), and the location of the stimulation electrodes. Hence, testing tDCS montages at several current levels would allow the selection of current parameters for improving stimulation outcomes and the comparison of montages...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28729133/hybrid-framework-for-feasible-modeling-of-an-edge-illumination-x-ray-phase-contrast-imaging-system-at-a-human-scale
#10
Bartłomiej Włodarczyk, Jakub Pietrzak
Here, we present a hybrid approach for simulating an edge illumination X-ray phase-contrast imaging (EIXPCi) set-up using graphics processor units (GPU) with a high degree of accuracy. In this study, the applicability of pixel, mesh and non-uniform rational B-splines (NURBS) objects to carry out realistic maps of X-ray phase-contrast distribution at a human scale is accounted for by using numerical anthropomorphic phantoms and a very fast and robust simulation framework which integrates total interaction probabilities along selected X-ray paths...
July 17, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28728807/the-impact-of-team-based-primary-care-on-health-care-services-utilization-and-costs-quebec-s-family-medicine-groups
#11
Erin Strumpf, Mehdi Ammi, Mamadou Diop, Julie Fiset-Laniel, Pierre Tousignant
We investigate the effects on health care costs and utilization of team-based primary care delivery: Quebec's Family Medicine Groups (FMGs). FMGs include extended hours, patient enrolment and multidisciplinary teams, but they maintain the same remuneration scheme (fee-for-service) as outside FMGs. In contrast to previous studies, we examine the impacts of organizational changes in primary care settings in the absence of changes to provider payment and outside integrated care systems. We built a panel of administrative data of the population of elderly and chronically ill patients, characterizing all individuals as FMG enrollees or not...
July 1, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28728469/characterizing-patients-with-multiple-chromosomal-aberrations-detected-by-fish-in-chronic-lymphocytic-leukemia
#12
Isabel González-Gascón Y Marín, María Hernández-Sanchez, Ana Eugenia Rodríguez-Vicente, Anna Puiggros, Rosa Collado, Elisa Luño, Teresa González, Neus Ruiz-Xivillé, Margarita Ortega, Eva Gimeno, Carolina Muñoz, Maria Stefania Infante, Julio Delgado, María Teresa Vargas, Marcos González, Francesc Bosch, Blanca Espinet, Jesús María Hernández-Rivas, José Ángel Hernández
We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months)...
July 21, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28727895/how-to-become-a-killer-or-is-it-all-accidental-virulence-strategies-in-oral-streptococci
#13
Izabela Sitkiewicz
Streptococci are a diverse group of gram positive microorganisms sharing common virulence traits and similar strategies to escape the oral niche and establish an infection in other parts of the host organism. Invasive infection with oral streptococci is "a perfect storm" that requires the concerted action of multiple biotic and abiotic factors. Our understanding of streptococcal pathogenicity and infectivity should probably be less mechanistic and driven not only by the identification of novel virulence factors...
July 20, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28727718/quantity-of-disc-removal-and-radiological-outcomes-of-percutaneous-endoscopic-lumbar-discectomy
#14
Ji Han Heo, Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Young-Geun Seo, Dong Hoi Kim, Sung Bae Park, Jung Hyeon Moon, Won Heo, Jong-Myung Jung
BACKGROUND: Herniated intervertebral disc disease (HIVD) is a common cause of lower back and leg pain. Percutaneous endoscopic lumbar discectomy (PELD) is indicated when non-surgical treatments such as medication and interventions are intractable. Ruptured discs and loose fragments inside discs are removed during PELD. Nerve root decompression is usually assessed by visualizing the free movement of the traversing nerve root or epidural fat, the free passage of a probe into the epidural space, the depression of the annulus, and the removal of the expected ruptured discs and loose fragments based on preoperative magnetic resonance images (MRI)...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727541/ic04750post-discharge-smoking-cessation-in-subgroups-of-hospitalized-smokers-a-latent-class-analysis
#15
Thomas Ylioja, Gerald Cochran, Yuchiao Chang, Hilary A Tindle, Nancy A Rigotti
CLEAN VERSION ABSTRACT Background: Hospitalization presents a window of opportunity to treat smoking, and hospital-initiated smoking treatment has demonstrated effectiveness. Despite effective interventions, not all smokers will discontinue use, highlighting the need to better understand which patients achieve cessation. Traditional regression methods may not capture the complexity of inpatient smoker subgroups. METHODS: We conducted latent class analysis (LCA) with data from 397 hospitalized adult cigarette smokers enrolled in a randomized trial...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28727044/muscle-lipid-metabolism-in-two-rabbit-lines-divergently-selected-for-intramuscular-fat
#16
M Martínez-Álvaro, S Agha, A Blasco, P Hernández
A divergent selection experiment for intramuscular fat (IMF) of LM at 9 wk of age was performed in rabbits. The objective of this work was to compare the lipid metabolism in muscles and fat tissues of the high-IMF and low-IMF lines. Lipogenic, catabolic, and lipolytic activities were studied in 2 muscles with different oxidative patterns (LM and semimembranosus proprius) and in the perirenal fat depot at 2 ages, 9 and 13 wk. In addition, adipocytes were characterized in perirenal fat. In the fifth generation, direct response to selection was 0...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726890/dynamics-and-resonances-of-the-h-2-s-ch-x-1-%C3%AE-reaction-in-the-electronic-ground-state-a-detailed-quantum-wavepacket-study
#17
P Sundaram, V Manivannan, R Padmanaban
Initial state-selected and energy resolved channel-specific reaction probabilities, integral cross sections and thermal rate constants of the H((2)S) + CH(+)(X(1)Σ(+)) reaction are calculated within the coupled states approximation by a time-dependent wave packet propagation method. The new ab initio global potential energy surface (PES) of the electronic ground state (1 (2)A') of the system, recently reported by Li et al. [J. Chem. Phys., 2015, 142, 124302], is employed for this purpose. All partial wave contributions up to the total angular momentum J = 60 are considered to obtain the converged integral reaction cross section up to a collision energy of 1...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726338/household-fear-of-deportation-in-mexican-origin-families-relation-to-body-mass-index-percentiles-and-salivary-uric-acid
#18
Airín D Martínez, Lillian Ruelas, Douglas A Granger
OBJECTIVE: Fear of deportation (FOD) is a prevalent concern among mixed-status families. Yet, our understanding of how FOD shapes human health and development is in its infancy. To begin to address this knowledge gap, we examined the relationship between household FOD, body mass index (BMI) percentiles and salivary uric acid (sUA), a biomarker related to oxidative stress/hypertension/metabolic syndrome, among 111 individuals living in Mexican-origin families. METHODS: Participants were 65 children (2 months-17 years, 49% female) and 46 adults (20-58 years, 71% female) living in 30 Mexican-origin families with at least one immigrant parent in Phoenix, AZ...
July 20, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28726024/thermal-physiology-of-three-sympatric-and-syntopic-liolaemidae-lizards-in-cold-and-arid-environments-of-patagonia-argentina
#19
F Duran, E L Kubisch, Jorgelina M Boretto
The thermal physiology determines the whole biology of ectotherm organisms, by limiting their acquisition and allocation of resources. Herein, we aim to add knowledge on how different species use the thermal resources when they coexist in a habitat, studying the thermal physiology of three sympatric and syntopic liolaemid lizards, Phymaturus querque, Phymaturus zapalensis, and Liolaemus elongatus during the summer season. We measured the body temperatures at capture places, the operative microenvironmental temperatures in the field, and the preferred body temperature in an experimental thermal gradient in the laboratory...
July 19, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28725910/preoperative-quality-of-life-questionnaires-are-an-adequate-tool-to-select-women-with-genital-prolapse-for-laparoscopic-sacrocolpopexy
#20
Enora Laas, Mattieu Haddad, Joël Muhlstein, Sofiane Bendifallah, Marcos Ballester, Emile Darai
INTRODUCTION AND HYPOTHESIS: No clear consensus exists on the selection of patients with pelvic organ prolapse (POP) for surgery. There is a need to preoperatively identify candidates who will benefit from surgery as there is no strict correlation between POP anatomical abnormalities and changes in symptoms and quality of life (QOL) after surgical treatment. Therefore, our objectives were to evaluate the changes in QOL after laparoscopic sacrocolpopexy (LSC) for POP using validated questionnaires and to assess their relevance in selecting women for surgery...
July 19, 2017: International Urogynecology Journal
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