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Double robustness

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https://www.readbyqxmd.com/read/28091642/robust-double-shelled-znga2o4-hollow-spheres-for-photocatalytic-reduction-of-co2-to-methane
#1
Yuan Zhang, Ping Li, Lan-Qin Tang, Yong-Qiang Li, Yong Zhou, Jun-Ming Liu, Zhi-Gang Zou
Robust, double-shelled ZnGa2O4 hollow spheres were successfully fabricated by hydrothermally treating an aqueous solution containing Zn(ii), Ga(iii), and citric acid, followed by annealing at 600 °C, 700 °C, or 800 °C in air to remove the carbon species. The hollow structure is expected to trap incident photons to enhance the light absorbance. The sample annealed at 700 °C exhibited the optimized photocatalytic performance in the reduction of CO2 in the presence of water vapor to methane. This property is ascribed to the improved crystallinity of the sample, which has fewer defect centers for the recombination of electron-hole pairs compared with that annealed at 600 °C...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28081561/a-novel-richardson-lucy-model-with-dictionary-basis-and-spatial-regularization-for-isolating-isotropic-signals
#2
Tiantian Xu, Yuanjing Feng, Ye Wu, Qingrun Zeng, Jun Zhang, Jianzhong He, Qichuan Zhuge
Diffusion-weighted magnetic resonance imaging is a non-invasive imaging method that has been increasingly used in neuroscience imaging over the last decade. Partial volume effects (PVEs) exist in sampling signal for many physical and actual reasons, which lead to inaccurate fiber imaging. We overcome the influence of PVEs by separating isotropic signal from diffusion-weighted signal, which can provide more accurate estimation of fiber orientations. In this work, we use a novel response function (RF) and the correspondent fiber orientation distribution function (fODF) to construct different signal models, in which case the fODF is represented using dictionary basis function...
2017: PloS One
https://www.readbyqxmd.com/read/28076378/p62-pathology-model-in-the-rat-substantia-nigra-with-filamentous-inclusions-and-progressive-neurodegeneration
#3
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body myositis. Since p62 functions in protein degradation pathways including autophagy, the build-up of p62-positive inclusions suggests defects in protein clearance. p62 was expressed unilaterally in the rat substantia nigra with an adeno-associated virus vector (AAV9) in order to study p62 neuropathology...
2017: PloS One
https://www.readbyqxmd.com/read/28075329/fano-andreev-effect-in-t-shape-double-quantum-dot-in-the-kondo-regime
#4
Ana Maria Calle, Monica Pacheco, George B Martins, Victor Apel, Gustavo Lara, Pedro Orellana
In the present work, we investigate the electronic transport through a T-shape double quantum dot system coupled to two normal leads and to one superconducting lead. We explore the interplay between Kondo and Andreev states due to proximity effects. We find that Kondo resonance is modified by the Andreev bound states, which manifest through Fano antiresonances in the local density of states of the embedded quantum dot and normal transmission. This means that there is a correlation between Andreev bound states and Fano resonances that is robust under the influence of high electronic correlation...
January 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28068613/behavioral-activation-treatment-for-major-depression-a-randomized-trial-of-the-efficacy-of-augmentation-with-cognitive-control-training
#5
Samantha J Moshier, Michael W Otto
BACKGROUND: Major depressive disorder (MDD) is associated with hypoactivation of the dorsolateral prefrontal cortex, a brain region involved in emotion regulation and basic cognitive control processes. Recent studies have indicated that computerized interventions designed to activate this region may reduce depressive and ruminative symptoms. In this double-blind randomized controlled trial, we tested whether one such program, called Cognitive Control Training (CCT), enhanced treatment outcomes when used in adjunct to brief behavior therapy for MDD...
January 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28061902/disposal-practices-of-unused-and-expired-pharmaceuticals-among-general-public-in-kabul
#6
Mohammadk Bashaar, Vijay Thawani, Mohamed Azmi Hassali, Fahad Saleem
BACKGROUND: Most of the medicine users remain unaware about the disposal of unused or expired medicines. The aim of this study was to know the disposal practices of unused and expired medicines among the general public in Kabul. METHODS: This was a descriptive, cross-sectional survey, conducted through face-to-face interviews using prevalidated structured questionnaire. Returned questionnaires were double-checked for accuracy. Statistical Package for Social Science (SPSS) version 23 was used for statistical analysis...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28060545/safety-and-immunogenicity-of-adenovirus-35-tb-vaccine-candidate-in-adults-with-active-or-previous-tb-a-randomized-trial
#7
Richard N van Zyl-Smit, Aliasgar Esmail, Mary E Bateman, Rodney Dawson, Jonathan Goldin, Eva van Rikxoort, Macaya Douoguih, Maria Grazia Pau, Jerald C Sadoff, J Bruce McClain, Margaret Ann Snowden, Jacqueline Benko, David A Hokey, Kathryn Tucker Rutkowski, Andrew Graves, Barbara Shepherd, Sadritdin Ishmukhamedov, Benjamin M N Kagina, Brian Abel, Willem A Hanekom, Thomas J Scriba, Eric D Bateman
RATIONALE: Administration of tuberculosis vaccines in participants with previous or current pulmonary tuberculosis may have the potential for causing harmful post-vaccination immunological (Koch-type) reactions. OBJECTIVES: To assess the safety and immunogenicity of three dose levels of the AERAS-402 live, replication-deficient adenovirus 35-vectored tuberculosis candidate vaccine, containing three mycobacterial antigens, in individuals with current or previous pulmonary tuberculosis...
January 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28060411/scarless-cas9-assisted-recombineering-no-scar-in-escherichia-coli-an-easy-to-use-system-for-genome-editing
#8
Christopher R Reisch, Kristala L J Prather
The discovery and development of genome editing systems that leverage the site-specific DNA endonuclease system CRISPR/Cas9 has fundamentally changed the ease and speed of genome editing in many organisms. In eukaryotes, the CRISPR/Cas9 system utilizes a "guide" RNA to enable the Cas9 nuclease to make a double-strand break at a particular genome locus, which is repaired by non-homologous end joining (NHEJ) repair enzymes, often generating random mutations in the process. A specific alteration of the target genome can also be generated by supplying a DNA template in vivo with a desired mutation, which is incorporated by homology-directed repair...
January 5, 2017: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/28059653/sulforaphane-suppresses-the-growth-of-glioblastoma-cells-glioblastoma-stem-cell-like-spheroids-and-tumor-xenografts-through-multiple-cell-signaling-pathways
#9
Khadijeh Bijangi-Vishehsaraei, M Reza Saadatzadeh, Haiyan Wang, Angie Nguyen, Malgorzata M Kamocka, Wenjing Cai, Aaron A Cohen-Gadol, Stacey L Halum, Jann N Sarkaria, Karen E Pollok, Ahmad R Safa
OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resistance in glioblastoma (GBM). Moreover, another complexity related to GBM treatment is the concept that GBM development and recurrence may arise from the expression of GBM stem cells (GSCs). Therefore, the use of a multifaceted approach or multitargeted agents that affect specific tumor cell characteristics will likely be necessary to successfully eradicate GBM. The objective of this study was to investigate the usefulness of sulforaphane (SFN)-a constituent of cruciferous vegetables with a multitargeted effect-as a therapeutic agent for GBM...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28057540/low-molecular-weight-heparin-coated-and-montelukast-filled-inhalable-particles-a-dual-drug-delivery-system-for-combination-therapy-in-asthma
#10
Brijeshkumar Patel, Jahidur Rashid, Nilesh Gupta, Fakhrul Ahsan
Montelukast, a cysteinyl leukotriene type 1 receptor antagonist, exhibits secondary anti-inflammatory properties when used at higher concentrations. Low molecular weight heparin (LMWH) evokes pronounced anti-inflammatory effects by interrupting leukocyte adhesion and migration. We hypothesized that inhalable particles containing montelukast plus LMWH release both drugs in a sustained fashion and protect the lungs against allergen-induced inflammation. Large porous particles of montelukast and LMWH were prepared using a double-emulsion-solvent-evaporation method...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28053086/myosin-iia-heavy-chain-phosphorylation-mediates-adhesion-maturation-and-protrusion-in-3d
#11
Vandana Rai, Dustin G Thomas, Jordan R Beach, Thomas T Egelhoff
Nonmuscle myosin II (NMII) is a conserved force-producing cytoskeletal enzyme with important but poorly understood roles in cell migration. To investigate myosin heavy chain (MHC) phosphorylation roles in 3D migration, we expressed GFP-tagged NMIIA wild type or mutant constructs in cells depleted of endogenous NMIIA protein. We find that individual mutation or double mutation of S1916 or S1943 to alanine potently blocks recruitment of GFP-NM-IIA filaments to leading edge protrusions in 2D, and this in turn blocks maturation of anterior focal adhesions...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28052863/double-stranded-rna-up-regulates-the-expression-of-inflammatory-mediators-in-human-aortic-valve-cells-through-the-tlr3-trif-non-canonical-nf-%C3%AE%C2%BAb-pathway
#12
Qiong Zhan, Rui Song, Fei Li, Lihua Ao, Qingchun Zeng, Dingli Xu, David A Fullerton, Xianzhong Meng
BACKGROUND: Calcific aortic valve disease (CAVD) is a chronic inflammatory condition and the inflammatory responses of aortic valve interstitial cells (AVICs) play a critical role in the disease progression. Double-stranded RNA (dsRNA) released from damaged or stressed cells is pro-inflammatory and may contribute to the mechanism of chronic inflammation observed in diseased aortic valves. The objective of this study is to determine the effect of dsRNA on AVIC inflammatory responses and the underlying mechanism...
January 4, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28051142/spin-polarized-current-injection-induced-magnetic-reconstruction-at-oxide-interface
#13
F Fang, Y W Yin, Qi Li, G Lüpke
Electrical manipulation of magnetism presents a promising way towards using the spin degree of freedom in very fast, low-power electronic devices. Though there has been tremendous progress in electrical control of magnetic properties using ferromagnetic (FM) nanostructures, an opportunity of manipulating antiferromagnetic (AFM) states should offer another route for creating a broad range of new enabling technologies. Here we selectively probe the interface magnetization of SrTiO3/La0.5Ca0.5MnO3/La0.7Sr0.3MnO3 heterojunctions and discover a new spin-polarized current injection induced interface magnetoelectric (ME) effect...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28048943/modeling-small-angle-x-ray-scattering-data-for-low-density-lipoproteins-insights-into-the-fatty-core-phase-packing-and-transition
#14
Selma Maric, Tania Kjellerup Lind, Jeppe Lyngsø, Marite Cardenas, Jan Skov Pedersen
Atherosclerosis and its clinical consequences are the leading cause of death in the west. While many studies throughout the last decades have aimed at understanding the disease, the clinical markers in use today still fail to accurately predict the risks. The role of the main clinical indicator of today, the low density lipoprotein (LDL), in depositing fat to the vessel wall is believed to be the onset of the process. However, many subfractions of the LDL, which differ both in structure and composition, are present in the blood and amongst different individuals...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28048330/th-ef-207a-04-a-dynamic-contrast-enhanced-cone-beam-ct-technique-for-evaluation-of-renal-functions
#15
Z Wang, J Shi, Y Yang
PURPOSE: To develop a simple but robust method for the early detection and evaluation of renal functions using dynamic contrast enhanced cone beam CT technique. METHODS: Experiments were performed on an integrated imaging and radiation research platform developed by our lab. Animals (n=3) were anesthetized with 20uL Ketamine/Xylazine cocktail, and then received 200uL injection of iodinated contrast agent Iopamidol via tail vein. Cone beam CT was acquired following contrast injection once per minute and up to 25 minutes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048093/su-f-j-27-segmentation-of-prostate-cbct-images-with-implanted-calypso-transponders-using-double-haar-wavelet-transform
#16
Y Liu, Z Saleh, Y Song, C Obcemea, M Chan, X Li, L Happersett, C Shi, X Qian, X Tang
PURPOSE: Segmentation of prostate CBCT images is an essential step towards real-time adaptive radiotherapy. It is challenging For Calypso patients, as more artifacts are generated by the beacon transponders. We herein propose a novel wavelet-based segmentation algorithm for rectum, bladder, and prostate of CBCT images with implanted Calypso transponders. METHODS: Five hypofractionated prostate patients with daily CBCT were studied. Each patient had 3 Calypso transponder beacons implanted, and the patients were setup and treated with Calypso tracking system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048043/su-f-j-212-enabling-conventional-cone-beam-ct-with-the-capability-of-dual-energy-imaging-using-a-simple-add-on-beam-modifier
#17
R Vinke, S Takao, K Umegaki, H Shirato, H Peng, L Xing
PURPOSE: In searching for a robust, efficient and cost-effective dual energy cone beam CT (DECBCT) solution for various radiation oncology applications, in particularly for improved proton dose planning/replanning accuracy and DE-CBCT guided radiation therapy, we investigate a novel energy modulation scheme using a beam modifier placed between the source and patient and optimize its geometric configuration for routine clinical use. METHODS: The study was performed using a Hitachi CBCT scanner and the tube voltage was set at 125 kVp...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047818/we-d-brb-01-basic-physics-of-proton-therapy
#18
B Arjomandy
: The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047628/we-d-brb-04-clinical-applications-of-cbct-for-proton-therapy
#19
B Teo
: The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047366/su-f-j-64-comparison-of-dosimetric-robustness-between-proton-therapy-and-imrt-plans-following-tumor-regression-for-locally-advanced-non-small-cell-lung-cancer-nsclc
#20
C Teng, C Ainsley, B Teo, B Burgdorf, G Janssens, A Berman, W Levin, Y Xiao, L Lin, C Simone, T Solberg
PURPOSE: In the light of tumor regression and normal tissue changes, dose distributions can deviate undesirably from what was planned. As a consequence, replanning is sometimes necessary during treatment to ensure continued tumor coverage or to avoid overdosing organs at risk (OARs). Proton plans are generally thought to be less robust than photon plans because of the proton beam's higher sensitivity to changes in tissue composition, suggesting also a higher likely replanning rate due to tumor regression...
June 2016: Medical Physics
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