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uric acid thrombolysis

Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas
Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress in stroke research. Relevant areas of interest include the search for safe and effective treatment strategies that combine neuroprotection reperfusion, better use of advanced brain imaging for patient selection, and wider implementation of prehospital conducted clinical trials...
July 2016: Lancet Neurology
Ilker Murat Caglar, Cem Ozde, Ismail Biyik, Fatma Nihan Turhan Caglar, Ibrahim Faruk Akturk, Murat Ugurlucan, Osman Karakaya
INTRODUCTION: The coronary slow flow phenomenon (CSFP) has been associated with myocardial ischemia, myocardial infarction, life-threatening arrhythmias, sudden cardiac death and increased cardiovascular mortality similar to coronary artery disease (CAD). Possible underlying mechanisms of CSFP are endothelial dysfunction, chronic inflammation, microvascular dysfunction and diffuse atherosclerosis. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) seems to play an important role in the pathogenesis of atherosclerosis...
February 1, 2016: Archives of Medical Science: AMS
Sergio Amaro, Ángel Chamorro
No abstract text is available yet for this article.
2016: Expert Review of Cardiovascular Therapy
Xiaoyan Yu, Jijun Shi, Chunli Jiang, Jiaping Xu, Shoujiang You, Yongjun Cao, Chunfeng Liu
OBJECTIVE: To evaluate the relation of serum uric acid levels on admission with short-term clinical outcome and hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis. METHODS: A total of 230 acute ischemic stroke patients treated with thrombolysis in our stroke unit from 2010 to 2013 were included. Demographics, disease severity, the uric acid levels on admission and hemorrhagic transformation were prospectively collected...
August 4, 2015: Zhonghua Yi Xue za Zhi
Halit Acet, Faruk Ertaş, Mehmet Zihni Bilik, Mehmet Ata Akıl, Ferhat Özyurtlu, Mesut Aydın, Mustafa Oylumlu, Nihat Polat, Murat Yüksel, Abdulkadir Yıldız, Hasan Kaya, Abdurrahman Akyüz, Hilal Ayçiçek, Mehmet Özbek, Nizamettin Toprak
INTRODUCTION: The thrombolysis in myocardial infarction (TIMI) risk score is calculated as the sum of independent predictors of mortality and ischemic events in ST elevation acute myocardial infarction (STEMI). Several studies show that the neutrophil to lymphocyte ratio (NLR) is a prognostic inflammatory marker. In preliminary studies, platelet to lymphocyte ratio (PLR) has been proposed as a pro-thrombotic marker. The relationship between NLR, PLR and TIMI risk score for STEMI has never been studied...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Laura Llull, Carlos Laredo, Arturo Renú, Belén Pérez, Elisabet Vila, Víctor Obach, Xabier Urra, Anna Planas, Sergio Amaro, Ángel Chamorro
BACKGROUND AND PURPOSE: It is unknown whether women and men with acute ischemic stroke respond similar to an antioxidant regimen administered in combination with thrombolysis. Here, we investigated the independent effect of sex on the response to uric acid (UA) therapy in patients with acute stroke treated with alteplase. METHODS: In the Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial, 206 women and 205 men were randomized to UA 1000 mg or placebo...
August 2015: Stroke; a Journal of Cerebral Circulation
Monica Verdoia, Lucia Barbieri, Gabriella Di Giovine, Paolo Marino, Harry Suryapranata, Giuseppe De Luca
The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, may be of predictive and prognostic value for cardiovascular (CV) events. We evaluated the relationship of NLR with the prevalence and extent of coronary artery disease (CAD) in consecutive patients undergoing elective or urgent coronary angiography. Our population (n = 3738 patients) was divided into NLR quartiles. Higher NLR was associated with aging and established CV risk factors, previous percutaneous coronary revascularization, acute presentation, and more complex pharmacological therapy...
January 2016: Angiology
Xuan Liu, Ming Liu, Miao Chen, Qin-Min Ge, Shu-Ming Pan
BACKGROUND: Exogenous uric acid (UA) is a neuroprotective antioxidant that reinforces the benefits of intravenous recombinant tissue plasminogen activator thrombolysis in animal thromboembolic stroke. However, whether serum uric acid (SUA) also increases the benefits of thrombolysis in Chinese patients with acute ischemic stroke (AIS) has yet to be fully defined. METHODS: A total of 216 consecutive AIS patients of Chinese origin treated with intravenous thrombolysis were enrolled in a prospective stroke registry...
May 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Halit Acet, Faruk Ertaş, Mehmet Ata Akıl, Ferhat Özyurtlu, Abdülkadir Yıldız, Nihat Polat, Mehmet Zihni Bilik, Mesut Aydın, Mustafa Oylumlu, Hasan Kaya, Murat Yüksel, Abdurrahman Akyüz, Hilal Ayçiçek, Sait Alan, Nizamettin Toprak
OBJECTIVE: The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and uric acid (UA) are inflammatory markers in cardiovascular disease. However, there are not enough data on infarct-related artery (IRA) patency in ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the association of NLR, PLR, and UA with IRA patency before percutaneous coronary intervention (PCI) in STEMI. METHODS: The study was designed as a retrospective study...
August 2015: Anatolian Journal of Cardiology
Abdurrezzak Börekçi, Mustafa Gür, Caner Türkoğlu, Şahbettin Selek, Ahmet Oytun Baykan, Taner Şeker, Hazar Harbalıoğlu, Betül Özaltun, İlyas Makça, Nurten Aksoy, Yavuz Gözükara, Murat Çaylı
In the pathogenesis of atherosclerosis, oxidative stress plays a major role in plaque instability, rupture, and erosion, which subsequently leads to thrombus formation and causes total infarct-related artery (IRA) occlusion. We investigated the relationship between spontaneous reperfusion (SR) of IRA and oxidative stress in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. A total of 341 consecutive patients with anterior STEMI were prospectively included in the present study...
March 2016: Clinical and Applied Thrombosis/hemostasis
Fatih Akin, Omer Celik, Burak Ayça, Ahmet Arif Yalçin, Ibrahim Altun, Nuri Köse
We evaluated the association between estimated glomerular filtration rate (eGFR) and slow coronary flow (SCF) in patients with normal to mildly impaired renal function; 211 patients with angiographically proven SCF and 219 controls were studied. Patients were categorized based on the angiographic findings as with or without SCF. We used the Modification of Diet in Renal Disease equation to calculate eGFR. The frequency of mildly decreased eGFR, serum uric acid levels, and eGFR was higher in the SCF group. Patients with mildly impaired renal function had higher thrombolysis in myocardial infarction frame counts in 3 major coronary arteries...
October 2014: Angiology
Sang-Hwa Lee, Sung Hyuk Heo, Jun-Hyun Kim, Dokyung Lee, Ji Sung Lee, Young Seo Kim, Hyun Young Kim, Seong-Ho Koh, Dae-Il Chang
Uric acid (UA) has been known to be a neuroprotective antioxidant because of its free radical scavenger activity. We studied the influence of UA in patients with acute ischemic stroke after thrombolytic therapy. Two hundred eighteen consecutive patients treated with intravenous thrombolysis were included in this analysis. We analyzed the relationship between serum UA levels obtained at the emergency department and clinical outcomes. Early improvement and excellent functional outcomes were measured using the National Institutes of Health Stroke Scale (NIHSS) 24 h after onset and the modified Rankin scale after 3 months...
2014: European Neurology
Durmuş Yıldıray Sahin, Mustafa Gür, Zafer Elbasan, Ali Yıldız, Zekeriya Kaya, Yahya Kemal Içen, Ali Kıvrak, Caner Türkoğlu, Remzi Yılmaz, Murat Caylı
BACKGROUND: Patients with ST-segment elevation myocardial infarction (STEMI) and a patent infarct-related artery (IRA) experience lower mortality and better clinical outcome, but little is known about the predictors of IRA patency before primary percutaneous coronary intervention (PCI) in the setting of STEMI. OBJECTIVE: To assess possible predictors of patency of IRA before primary PCI in patients with STEMI. METHODS: A total of 880 patients with STEMI undergoing primary PCI were prospectively included (646 male, 234 female; mean [± SD] age 58...
2013: Experimental and Clinical Cardiology
Jin-wen Wang, Yun-dai Chen, Chang-hua Wang, Xiao-ling Zhu
OBJECTIVE: To explore the association of the uric acid levels and coronary blood flow in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS: A total of 276 STEMI patients undergoing primary PCI were enrolled and divided into 2 groups based upon the Thrombolysis in Myocardial Infarction (TIMI) flow grade. No-reflow was defined as TIMI Grade 0, 1 and 2 flows. The association of uric acid levels on admission with TIMI flow grade after PCI was assessed by multivariate Logistic regression...
November 27, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Su Wang, Yanyan Zhang, Yutong Cheng, Ji Huang, Tao Sun, Tong Liu, Qian Wang, Chengqian Yin, Ying Tao, Bin Que, Jingmei Zhang, Zhizhong Li, Yujie Zhou
BACKGROUND: Whether the hematocrit is implicated in the pathogenesis of slow coronary flow (SCF) is not known. METHODS: To evaluate the correlation between the hematocrit and SCF, we studied 367 patients with angiographically near-normal coronary arteries. They were divided into four quartiles based on the hematocrit. The corrected thrombolysis in myocardial infarction frame count (TFC) was used to document velocity of coronary flow. RESULTS: From the first through to the fourth quartile, the percentage of males and those who smoked as well as serum levels of creatinine, uric acid and triglyceride increased (p < 0...
2014: Clinical Hemorheology and Microcirculation
Nicola Logallo, Halvor Naess, Titto T Idicula, Jan Brogger, Ulrike Waje-Andreassen, Lars Thomassen
BACKGROUND: A possible synergic role of serum uric acid (SUA) with thrombolytic therapies is controversial and needs further investigations. We therefore evaluated association of admission SUA with clinical improvement and clinical outcome in patients receiving rt-PA, early admitted patients not receiving rt-PA, and patients admitted after time window for rt-PA. METHODS: SUA levels were obtained at admission and categorized as low, middle and high, based on 33° and 66° percentile values...
2011: BMC Neurology
Sergio Amaro, Ángel Chamorro
Stroke is an enormous public health problem with an imperative need for more effective therapy. Recombinant tissue plasminogen activator is the only licensed drug for acute stroke, but its efficacy may be limited by the toxicity of the compound and by reperfusion injury. The coadministration of neuroprotective drugs could augment the value of thrombolytic therapy, but the evidence in support of this approach is scarce. The use of the free radical trapping NXY-059, either with or without recombinant tissue plasminogen activator, was not successful in Phase III studies...
May 2011: Stroke; a Journal of Cerebral Circulation
Nurcan Basar, Nihat Sen, Firat Ozcan, Gonul Erden, Selcuk Kanat, Erdogan Sokmen, Ahmet Isleyen, Huseyin Yuzgecer, Mehmet Fatih Ozlu, Metin Yildirimkaya, Orhan Maden, Adrian Covic, Richard J Johnson, Mehmet Kanbay
BACKGROUND: Serum uric acid (SUA) is associated with microvascular disease that could alter coronary blood flow and prognosis. We evaluated the effects of admission SUA levels on coronary blood flow and prognosis in 185 consecutive patients with ST-segment elevation myocardial infarction (STEMI) who underwent acute primary percutaneous coronary intervention (PCI). METHODS: Patients undergoing PCI for an acute STEMI were stratified into elevated SUA (>6.5 mg/dL) and normal SUA group (≤6...
August 2011: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Sergio Amaro, Xabier Urra, Manuel Gómez-Choco, Víctor Obach, Alvaro Cervera, Martha Vargas, Ferran Torres, Jose Rios, Anna M Planas, Angel Chamorro
BACKGROUND AND PURPOSE: Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. METHODS: A total of 317 consecutive patients treated with thrombolysis were included in a prospective stroke registry. Demographics, laboratory data, neurological course, and infarction volume were prospectively collected...
January 2011: Stroke; a Journal of Cerebral Circulation
Ali Yildiz, Remzi Yilmaz, Recep Demirbag, Mustafa Gur, Mehmet Memduh Bas, Ozcan Erel
OBJECTIVES: Slow coronary flow (SCF) has long since been identified and endothelial dysfunction and atherosclerosis of the epicardial coronary arteries and microvasculature are reported to be associated with SCF. Serum uric acid is an independent biochemical marker of atherosclerosis, oxidative stress and endothelial dysfunction. Consequently, we aimed to investigate the association between coronary blood flow and serum uric acid level by means of thrombolysis in myocardial infarction frame count (TFC) and other laboratory parameters, in patients with SCF compared with control participants...
December 2007: Coronary Artery Disease
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