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Regerative Medicine

E Carlos Rodriguez-Merchan, Leonard A Valentino
The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy (HA) in patients with deficiency of coagulation factor VIII or IX and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these problems. Lifelong factor replacement therapy (FRT) is optimal to prevent HA, however adherence to this regerous treatment is challenging leading to breakthrough bleeding. In patients with chronic hemophilic synovitis, the prelude to HA, radiosynovectomy (RS) is the optimal to ameliorate bleeding...
June 18, 2016: World Journal of Orthopedics
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, John D Schreier, Rowena V Cube, Christopher D Cox, Dansu Li, Wei Lemaire, Joseph G Bruno, C Meacham Harrell, Susan L Garson, Anthony L Gotter, Steven V Fox, Joanne Stevens, Pamela L Tannenbaum, Thomayant Prueksaritanont, Tamara D Cabalu, Donghui Cui, Joyce Stellabott, George D Hartman, Steven D Young, Christopher J Winrow, John J Renger, Paul J Coleman
Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. The majority of clinical efforts to date have focused on the development of dual orexin receptor antagonists (DORAs), small molecules that antagonize both the orexin 1 and orexin 2 receptors. Our group has recently disclosed medicinal chemistry efforts to identify highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. Herein we report additional SAR studies within the 'triaryl' amide 2-SORA series focused on improvements in compound stability in acidic media and time-dependent inhibition of CYP3A4...
October 15, 2014: Bioorganic & Medicinal Chemistry Letters
Albert Rizzo, Thomas D Parsons, Belinda Lange, Patrick Kenny, John G Buckwalter, Barbara Rothbaum, JoAnn Difede, John Frazier, Brad Newman, Josh Williams, Greg Reger
Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in returning OEF/OIF military personnel is creating a significant healthcare challenge. These findings have served to motivate research on how to better develop and disseminate evidence-based treatments for PTSD. Virtual Reality delivered exposure therapy for PTSD has been previously used with reports of positive outcomes. This article details how virtual reality applications are being designed and implemented across various points in the military deployment cycle to prevent, identify and treat combat-related PTSD in OIF/OEF Service Members and Veterans...
June 2011: Journal of Clinical Psychology in Medical Settings
Albert A Rizzo, Belinda Lange, John G Buckwalter, Eric Forbell, Julia Kim, Kenji Sagae, Josh Williams, Barbara O Rothbaum, JoAnn Difede, Greg Reger, Thomas Parsons, Patrick Kenny
Over the last 15 years, a virtual revolution has taken place in the use of Virtual Reality simulation technology for clinical purposes. Shifts in the social and scientific landscape have now set the stage for the next major movement in Clinical Virtual Reality with the "birth" of intelligent virtual humans. Seminal research and development has appeared in the creation of highly interactive, artificially intelligent and natural language capable virtual human agents that can engage real human users in a credible fashion...
2011: Studies in Health Technology and Informatics
Christine Reger, David W Kennedy
The increased complexity of medicine, the imperative of reducing health care costs, and the goals of improving quality and patient satisfaction require that we rethink current models of practice. Such reevaluation will receive additional impetus from workforce changes within medicine and the specialty. Furthermore, as chronic disorder care becomes more complex, it may increasingly be provided within a specialty setting. Our goal is to stimulate discussion regarding the potential for alternative health care delivery models within the specialty in the face of predicted workforce shortages and the impetus toward health care reform...
December 2009: Otolaryngology—Head and Neck Surgery
Gregory A Gahm, Robert D Swanson, Barbara A Lucenko, Mark A Reger
The Department of Defense mandates a health reassessment at 90 to 180 days following return from deployment. Essential components include a review of mental and physical health symptoms and follow-up referral. Fort Lewis developed a program that exceeds these basic requirements to provide additional screening and on-site services, including face-to-face visits with a credentialed mental health provider for all soldiers. This program, the Soldier Wellness Assessment Program (SWAP), also extends these services to the predeployment window (120 to 45 days) to identify problems before deployment early enough to treat them...
July 2009: Military Medicine
Greg M Reger, Gregory A Gahm, Albert A Rizzo, Robert Swanson, Susan Duma
Repeated combat deployments to Iraq and Afghanistan are resulting in increased rates of posttraumatic stress disorder (PTSD) among military personnel. Although exposure therapy is an effective treatment for this disorder, some personnel do not significantly respond to treatment, possibly due to poor activation of the trauma memory or a lack of emotional engagement during therapy. In addition, some service members do not seek mental healthcare due to treatment stigma. Researchers recently developed a virtual reality (VR) Iraq to attempt to improve activation of the traumatic memory during exposure therapy and to provide a treatment approach that may be more appealing to some service members, relative to traditional face-to-face talk therapy...
January 2009: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Greg Reger, Ana Wong-McDonald, Robert Paul Liberman
No abstract text is available yet for this article.
November 2003: Psychiatric Services: a Journal of the American Psychiatric Association
T B Reger, D Roditski
Changes in patients' care mandate that nursing care be amenable to change. With the advent of new technology, systems of care delivery are evolving. Blood transfusion practices that were once considered standards are being reexamined and redefined. Nurses, in their roles as patients' advocates and educators, must be cognizant of changes in practice and be prepared to deliver competent care. The effectiveness of techniques of bloodless medicine and surgery originally designed to serve the needs of Jehovah's Witnesses is accepted today, and other groups of patients are choosing this type of care...
August 2001: Critical Care Nurse
S I Reger, T C Adams, J A Maklebust, V Sahgal
OBJECTIVE: To develop a simple, reproducible validation test protocol for classification of air-loss support systems. DESIGN: Simultaneous experimental measurement of moisture loss and temperature reduction at the air-loss support surface-human body equivalent interface from a sweating human skin analogue. SETTING: A hospital department of physical medicine and rehabilitation. OTHER PARTICIPANTS: These 3 manufacturers contributed 14 support surfaces...
May 2001: Archives of Physical Medicine and Rehabilitation
R B Reger
No abstract text is available yet for this article.
December 1974: Journal of Occupational Medicine.: Official Publication of the Industrial Medical Association
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