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https://www.readbyqxmd.com/read/28544919/risk-factors-for-patient-reported-errors-during-cancer-follow-up-results-from-a-national-survey-in-denmark
#1
Anne Hjøllund Christiansen, Henriette Lipczak, Janne Lehmann Knudsen, Anne Mette Tranberg Kejs
Due to an increased cancer survival, more cancer patients are referred to follow-up after primary treatment. Knowledge of patient safety during follow-up is sparse. OBJECTIVE: To examine patient-reported errors during cancer follow-up and identify factors associated with errors. DESIGN: A national survey on cancer patients' experiences of treatment and aftercare was conducted in 2012, about two years following cancer diagnosis (N=6914). Associations between patient-reported errors during follow-up and covariates were examined using multiple logistic regression...
May 22, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28541924/characterizing-highly-benefited-patients-in-randomized-clinical-trials
#2
Vivek Charu, Paul B Rosenberg, Lon S Schneider, Lea T Drye, Lisa Rein, David Shade, Constantine G Lyketsos, Constantine E Frangakis
Physicians and patients may choose a certain treatment only if it is predicted to have a large effect for the profile of that patient. We consider randomized controlled trials in which the clinical goal is to identify as many patients as possible that can highly benefit from the treatment. This is challenging with large numbers of covariate profiles, first, because the theoretical, exact method is not feasible, and, second, because usual model-based methods typically give incorrect results. Better, more recent methods use a two-stage approach, where a first stage estimates a working model to produce a scalar predictor of the treatment effect for each covariate profile; and a second stage estimates empirically a high-benefit group based on the first-stage predictor...
May 20, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/28535776/the-role-of-anti-ige-omalizumab-xolair-in-the-management-of-severe-recalcitrant-paediatric-atopic-eczema-adapt-statistical-analysis-plan
#3
Tao Chen, Susan Chan, Gideon Lack, Suzie Cro, Victoria R Cornelius
BACKGROUND: The Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT) is a trial to determine the clinical efficacy and safety of omalizumab for children with severe atopic eczema. This article describes the detailed statistical analysis plan for the ADAPT as an update to the published protocol and is submitted prior to knowing all outcomes. METHOD AND DESIGN: The ADAPT is a randomised, double-blind, placebo-controlled trial with a primary objective to determine whether anti-IgE reduces eczema severity as assessed by the validated eczema score (objective SCORAD) after 24 weeks of treatment in children with severe eczema...
May 23, 2017: Trials
https://www.readbyqxmd.com/read/28530430/subjective-social-status-life-course-ses-and-bmi-in-young-adulthood
#4
Matt Bradshaw, Blake Victor Kent, W Matthew Henderson, Anna Catherine Setar
OBJECTIVE: Socioeconomic status (SES) is associated with many aspects of health and well-being, including body mass index (BMI). Most research in this area has focused on objective indicators of SES such as education and income, but recent work suggests that subjective social status (SSS) is also important. This study contributes to a growing body of research on SSS and BMI. METHOD: Data from Waves I and IV the National Longitudinal Study of Adolescent to Adult Health (Add Health), a study of 14,780 individuals followed from adolescence to young adulthood, were analyzed...
May 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28529839/estimating-effects-with-rare-outcomes-and-high-dimensional-covariates-knowledge-is-power
#5
Laura Balzer, Jennifer Ahern, Sandro Galea, Mark van der Laan
Many of the secondary outcomes in observational studies and randomized trials are rare. Methods for estimating causal effects and associations with rare outcomes, however, are limited, and this represents a missed opportunity for investigation. In this article, we construct a new targeted minimum loss-based estimator (TMLE) for the effect or association of an exposure on a rare outcome. We focus on the causal risk difference and statistical models incorporating bounds on the conditional mean of the outcome, given the exposure and measured confounders...
December 2016: Epidemiologic Methods
https://www.readbyqxmd.com/read/28529606/comparison-of-prognostic-nomograms-based-on-different-nodal-staging-systems-in-patients-with-resected-gastric-cancer
#6
Zi-Xian Wang, Miao-Zhen Qiu, Yu-Ming Jiang, Zhi-Wei Zhou, Guo-Xin Li, Rui-Hua Xu
Purpose: Previous studies addressing the optimal nodal staging system in patients with resected gastric cancer have shown inconsistent results, and the optimal system for development of prognostic nomograms remains unclear. In this study, we compared prognostic nomograms based on the metastatic lymph node (MLN) count, lymph node ratio (LNR), and log odds of metastatic lymph nodes (LODDS) to predict the 5-year overall survival in patients with resected gastric cancer. Methods: We analysed 15,320 patients with resected gastric cancer in the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2010...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28498610/diabetes-distress-is-linked-with-worsening-diabetes-management-over-time-in-adults-with-type%C3%A2-1-diabetes
#7
D M Hessler, L Fisher, W H Polonsky, U Masharani, L A Strycker, A L Peters, I Blumer, V Bowyer
AIM: To determine the cross-sectional and longitudinal associations between diabetes distress and diabetes management. METHODS: In a non-interventional study, 224 adults with Type 1 diabetes were assessed for diabetes distress, missed insulin boluses, hypoglycaemic episodes, and HbA1c at baseline and 9 months. RESULTS: At baseline, greater distress was associated with higher HbA1c and a greater percentage of missed insulin boluses. Longitudinally, elevated baseline distress was related to increased missed insulin boluses, and decreases in distress were associated with decreases in HbA1c ...
May 12, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28496285/partial-identification-in-the-statistical-matching-problem
#8
Daniel Ahfock, Saumyadipta Pyne, Sharon X Lee, Geoffrey J McLachlan
The statistical matching problem involves the integration of multiple datasets where some variables are not observed jointly. This missing data pattern leaves most statistical models unidentifiable. Statistical inference is still possible when operating under the framework of partially identified models, where the goal is to bound the parameters rather than to estimate them precisely. In many matching problems, developing feasible bounds on the parameters is equivalent to finding the set of positive-definite completions of a partially specified covariance matrix...
December 2016: Computational Statistics & Data Analysis
https://www.readbyqxmd.com/read/28488886/network-support-technology-use-depression-and-art-adherence-among-hiv-positive-msm-of-color
#9
I W Holloway, D Tan, S L Dunlap, L Palmer, S Beougher, J A Cederbaum
Depression is associated with poor antiretroviral therapy (ART) adherence among people living with HIV/AIDS. This relationship may be moderated by an individual's social network characteristics. Our study sought to examine social network correlates of treatment adherence among HIV-positive men recruited from social service agencies throughout Los Angeles County (N = 150) to inform technology-driven social support interventions for this population. We administered egocentric social network and computer-assisted survey interviews focused on demographic characteristics, health history, depressive symptoms, and ART adherence, where adherence was assessed by the number of reasons participants missed taking their medication, if ever...
May 10, 2017: AIDS Care
https://www.readbyqxmd.com/read/28487471/using-dti-to-assess-white-matter-microstructure-in-cerebral-small-vessel-disease-svd-in-multi-centre-studies
#10
Iain David Croall, Valerie Lohner, Barry Moynihan, Usman Khan, Ahamad Hassan, John T O'Brien, Robin G Morris, Daniel J Tozer, Victoria C Cambridge, Kirsty Harkness, David Werring, Andrew M Blamire, Gary A Ford, Thomas R Barrick, Hugh S Markus
Diffusion tensor imaging (DTI) metrics such as Fractional Anisotropy (FA) and Mean Diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease due to their associations with outcomes such as cognition. However, studies investigating this have been predominantly single-centre. As clinical trials are likely to be multi-site, further studies are required to determine whether associations with cognition of similar strength can be detected in a multi-centre setting. 109 patients (mean age=68) with symptomatic lacunar infarction and confluent white matter hyperintensities (WMH) on MRI was recruited across 6 sites as part of the PRESERVE DTI sub-study...
May 9, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28486574/assessing-the-potential-for-bias-from-non-response-to-a-study-follow-up-interview-an-example-from-the-agricultural-health-study
#11
Jessica L Rinsky, David B Richardson, Steve Wing, John D Beard, Michael Alavanja, Laura E Beane Freeman, Honglei Chen, Paul K Henneberger, Freya Kamel, Dale P Sandler, Jane A Hoppin
Prospective cohort studies are important tools for identifying causes of disease. However, these studies are susceptible to attrition. When information collected after enrollment is through interview or exam, attrition leads to missing information for non-respondents. The Agricultural Health Study enrolled 52,394 farmers in 1993-1997 and collected additional information during subsequent interviews. Forty-six percent of enrolled farmers responded to the 2005-2010 interview; 7% of farmers died prior to interview...
May 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28486089/gout-can-increase-the-risk-of-receiving-rotator-cuff-tear-repair-surgery
#12
Shih-Wei Huang, Chin-Wen Wu, Li-Fong Lin, Tsan-Hon Liou, Hui-Wen Lin
BACKGROUND: Gout commonly involves joint inflammation, and clinical epidemiological studies on involved tendons are scant. Rotator cuff tears are the most common cause of shoulder disability, and surgery is one of the choices often adopted to regain previous function. PURPOSE: To investigate the risk of receiving rotator cuff repair surgery among patients with gout and to analyze possible risk factors to design an effective prevention strategy. STUDY DESIGN: Cohort study; Level of evidence, 3...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28483064/missed-opportunities-for-hepatitis-a-vaccination-national-immunization-survey-child-2013
#13
Shannon M Casillas, Robert A Bednarczyk
OBJECTIVES: To quantify the number of missed opportunities for vaccination with hepatitis A vaccine in children and assess the association of missed opportunities for hepatitis A vaccination with covariates of interest. STUDY DESIGN: Weighted data from the 2013 National Immunization Survey of US children aged 19-35 months were used. Analysis was restricted to children with provider-verified vaccination history (n = 13 460). Missed opportunities for vaccination were quantified by determining the number of medical visits a child made when another vaccine was administered during eligibility for hepatitis A vaccine, but hepatitis A vaccine was not administered...
May 5, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28476472/adverse-outcomes-associated-with-pulmonary-hypertension-in-chronic-obstructive-pulmonary-disease-after-bilateral-lung-transplantation
#14
Don Hayes, Dmitry Tumin, Maria M Budev, Joseph D Tobias, Roy C St John, Jasleen Kukreja
BACKGROUND: The impact of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) on survival after lung transplantation (LTx) is not known. MATERIAL AND METHODS: First-time adult LTx recipients with COPD transplanted between May 2005 and September 2013 were identified in the United Network for Organ Sharing Registry database, and tracked from transplant date until death or censoring. Right heart catheterization (RHC) measurements at time of wait listing were used to predict all-cause mortality after LTx, with multivariable analyses stratified by transplant type...
April 22, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28476272/factors-associated-with-ongoing-criminal-engagement-while-in-opioid-maintenance-treatment
#15
Marianne Riksheim Stavseth, Jo Røislien, Anne Bukten, Thomas Clausen
INTRODUCTION: This study examines factors associated with criminal engagement among patients in opioid maintenance treatment (OMT). METHODS: Questionnaire data recorded annually among 5654 patients in the Norwegian OMT programme between 2005 and 2010 from seven regional treatment centres were available for analyses. Each patient answered approximately 4 times (mean: 4.11, SD: 1.46) generating a total of 18,538 questionnaires. The outcome variable of the study, engagement in criminal activity, was defined as whether a patient had been arrested, put in custody, been charged and/or convicted of a crime within the last 12months prior to the completion of the questionnaire...
June 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28466482/msec-queryable-global-layers-of-environmental-and-anthropogenic-variables-for-marine-ecosystem-studies
#16
Lauren A Yeager, Philippe Marchand, David A Gill, Julia K Baum, Jana M McPherson
Biophysical conditions, including climate, environmental stress, and habitat availability, are key drivers of many ecological processes (e.g., community assembly and productivity) and associated ecosystem services (e.g., carbon sequestration and fishery production). Furthermore, anthropogenic impacts such as coastal development and fishing can have drastic effects on the structure and function of marine ecosystems. Scientists need to account for environmental variation and human impacts to accurately model, manage, and conserve marine ecosystems...
May 3, 2017: Ecology
https://www.readbyqxmd.com/read/28464562/pattern-mixture-models-for-clinical-validation-of-biomarkers-in-the-presence-of-missing-data
#17
Fei Gao, Jun Dong, Donglin Zeng, Alan Rong, Joseph G Ibrahim
Targeted therapies for cancers are sometimes only effective in a subset of patients with a particular biomarker status. In clinical development, the biomarker status is typically determined by an investigational-use-only/laboratory-developed test. A market ready test (MRT) is developed later to meet regulatory requirements and for future commercial use. In the USA, the clinical validation of MRT showing efficacy and safety profile of the targeted therapy in the biomarker subgroups determined by MRT is needed for pre-market approval...
May 2, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28454521/age-and-gender-differences-in-the-association-between-social-participation-and-instrumental-activities-of-daily-living-among-community-dwelling-elderly
#18
Kimiko Tomioka, Norio Kurumatani, Hiroshi Hosoi
BACKGROUND: Although many studies have suggested social participation (SP) has beneficial effects on elderly people's health, most of them failed to deal with paid work. Additionally, few studies have focused on the age effect between SP and older people's health. To investigate whether the association between SP, including paid work, and instrumental activities of daily living (IADL), exhibits not only in gender, but also in age among community-dwelling older adults. METHODS: In 2014, we distributed self-administered questionnaires to all community-dwelling elderly aged ≥65 in two medium-sized cities in Nara Prefecture, Japan (n = 32,825)...
April 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28453697/prediction-of-overall-survival-in-stage-ii-and-iii-colon-cancer-beyond-tnm-system-a-retrospective-pooled-biomarker-study
#19
R Dienstmann, M J Mason, F A Sinicrope, A I Phipps, S Tejpar, A Nesbakken, S A Danielsen, A Sveen, D D Buchanan, M Clendenning, C Rosty, B Bot, S R Alberts, J Milburn Jessup, R A Lothe, M Delorenzi, P A Newcomb, D Sargent, J Guinney
Background: TNM staging alone does not accurately predict outcome in colon cancer (CC) patients who may be eligible for adjuvant chemotherapy. It is unknown to what extent the molecular markers microsatellite instability (MSI) and mutations in BRAF or KRAS improve prognostic estimation in multivariable models that include detailed clinicopathological annotation. Patients and methods: After imputation of missing at random data, a subset of patients accrued in phase 3 trials with adjuvant chemotherapy (n = 3016)-N0147 (NCT00079274) and PETACC3 (NCT00026273)-was aggregated to construct multivariable Cox models for 5-year overall survival that were subsequently validated internally in the remaining clinical trial samples (n = 1499), and also externally in different population cohorts of chemotherapy-treated (n = 949) or -untreated (n = 1080) CC patients, and an additional series without treatment annotation (n = 782)...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453370/school-absence-and-productivity-outcomes-associated-with-childhood-asthma-in-the-usa
#20
Patrick Sullivan, Vahram G Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhisek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Previous studies have examined the association between childhood asthma and lost productivity; however, more data are needed to understand its impact. METHODS: This was a retrospective analysis of cross-sectional data in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). School-aged children (SAC), children (age 6-11), and adolescents (age 12-17) with asthma were compared to those without asthma to examine annual missed school days...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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