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https://www.readbyqxmd.com/read/27910104/long-term-reproducibility-of-positive-patch-test-reactions-in-patients-with-non-immediate-cutaneous-adverse-drug-reactions-to-antibiotics
#1
André Pinho, Ana Marta, Inês Coutinho, Margarida Gonçalo
BACKGROUND: As in contact allergy, T cell-mediated hypersensitivity in non-immediate (NI) cutaneous adverse drug reactions (CADRs) to antibiotics is considered to be lifelong, but, in this setting, patch tests have rarely been repeated after long time intervals. OBJECTIVE: To evaluate the long-term reproducibility of positive patch test reactions to antibiotics in patients with NI CADRs. METHODS: Fifty-six patients with NI CADRs to antibiotics who had relevant positive reactions during patch testing were invited to repeat patch tests with a similar antibiotic series 2-15 years thereafter...
December 2, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27901259/neurological-manifestations-of-chikungunya-and-zika-infections
#2
Talys J Pinheiro, Luis F Guimarães, Marcus Tulius T Silva, Cristiane N Soares
The epidemics of Chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have been considered the most important epidemiological occurrences in the Americas. The clinical picture of CHIKV infection is characterized by high fever, exanthema, myalgia, headaches, and arthralgia. Besides the typical clinical picture of CHIKV, atypical manifestations of neurological complications have been reported: meningo-encephalitis, meningoencephalo-myeloradiculitis, myeloradiculitis, myelitis, myeloneuropathy, Guillain-Barré syndrome and others...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27900921/-a-fixed-drug-eruption-caused-by-paracetamol
#3
L van Zogchel, T Hendriks, S Adriaens, I Diederen, E Herremans
BACKGROUND: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1.5% of cases. CASE DESCRIPTION: A 58-year-old man was seen in general practice with a five-year-old exanthema on his torso, arms and legs...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#4
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27876188/-infant-with-exanthema-and-fever
#5
Sara Barbed-Ferrández, Marta Arrudi-Moreno, Marcial Álvarez-Salafranca, Matilde Bustillo-Alonso
No abstract text is available yet for this article.
November 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27865864/construction-and-manipulation-of-a-full-length-infectious-bacterial-artificial-chromosome-clone-of-equine-herpesvirus-type-3-ehv-3
#6
Maksat Akhmedzhanov, Mariela Scrochi, Maria Barrandeguy, Aldana Vissani, Nikolaus Osterrieder, Armando Mario Damiani
Equine herpesvirus type 3 (EHV-3) is the causal agent of equine coital exanthema, a disease characterized by pox-like lesions on the penis of stallions and the vulva of mares. Although the complete genomic sequence of EHV-3 has been recently made available, its genomic content remains poorly characterized and the molecular mechanisms of disease development not yet elucidated. In an attempt to facilitate genetic manipulation of EHV-3, we describe here the construction of a full-length infectious bacterial artificial chromosome (BAC) clone of EHV-3...
November 16, 2016: Virus Research
https://www.readbyqxmd.com/read/27812648/zika-in-pernambuco-rewriting-the-first-outbreak
#7
Carlos Alexandre Antunes de Brito, Cecilia Coelho Moraes de Brito, Augusto César Oliveira, Marilia Rocha, Caio Atanásio, Carolina Asfora, Júlio Dourado Matos, Anton Saraiva Lima, Maria Fátima Militão Albuquerque
INTRODUCTION: A Zika virus epidemic was registered in 2015 in Northeast Brazil. In the State of Pernambuco, thousands of classical cases transpired, and in the following months, neurological disturbances in adults and microcephaly in newborns emerged as complications. After the peak of the epidemic, the official system reported only four cases of Zika virus but over 100,000 cases of dengue virus. The vigilance system was unable to retrospectively estimate cases or to issue an alert to officially notified cases with possible inconsistence concerning specific arbovirosis diagnoses...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27788881/slow-desensitization-of-imatinib-induced-nonimmediate-reactions-and-dynamic-changes-of-drug-specific-cd4-cd25-cd134-lymphocytes
#8
Jettanong Klaewsongkram, Pattarawat Thantiworasit, Pimpayao Sodsai, Supranee Buranapraditkun, Pungjai Mongkolpathumrat
BACKGROUND: Imatinib is a tyrosine kinase inhibitor indicated for the treatment of gastrointestinal stromal tumors (GISTs) and certain neoplastic diseases; however, nonimmediate adverse reactions are common. OBJECTIVE: To describe the process of imatinib slow desensitization in patients who experienced nonimmediate reactions to imatinib and the dynamic change in drug-specific CD4(+)CD25(+)CD134(+) T-lymphocyte percentages. METHODS: Five patients diagnosed as having GISTs and with a recent history of imatinib-induced nonimmediate reactions (maculopapular exanthema with eosinophilia, exfoliative dermatitis, palmar-plantar erythrodysesthesia, and drug rash with eosinophilia and systemic symptoms) were desensitized using a slow desensitization protocol...
November 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27773488/update-on-infections-with-human-herpesviruses-6a-6b-and-7
#9
H Agut, P Bonnafous, A Gautheret-Dejean
Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7) are genetically related to cytomegalovirus. They belong to the Roseolovirus genus and to the Betaherpesvirinae subfamily. They infect T cells, monocytes-macrophages, epithelial cells, and central nervous system cells. These viruses are ubiquitous and are responsible for lifelong chronic infections, most often asymptomatic, in the vast majority of the general adult population. HHV-6B is responsible for exanthema subitum, which is a benign disease of infants...
October 20, 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27770133/-epidermal-barrier-disorders-in-dermatoses
#10
E Proksch, D Dähnhardt, S Dähnhardt-Pfeiffer, R Fölster-Holst
The permeability barrier plays an important role in numerous skin diseases. Particularly well known is the importance of this barrier in eczema. In irritative-toxic contact dermatitis, the first step in the pathogenesis is the disturbance of the permeability barrier by irritative-toxic noxious substances. Only after damage to the barrier is achieved can irritants and allergens penetrate into the living epidermis. In atopic eczema due to an impaired barrier, allergens penetrate from the environment into the skin and cause or worsen the eczema...
October 21, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27761922/urticarial-exanthema-due-to-hepatitis-b-in-a-pregnant-woman-mimicking-a-polymorphic-eruption-of-pregnancy
#11
B Lozano-Masdemont, L Gómez-Recuero-Muñoz, A Pulido-Pérez, I Molina-López, R Suárez-Fernández
Hepatitis B virus (HBV) infection in pregnant women is very rare in western countries, thus, cutaneous manifestation of HBV infection may be confused with a dermatosis specific of pregnancy. We report a 39-year-old woman who presented in her 20th week of pregnancy with a pruritic rash, which consisted of generalized erythematous plaques, some of them with a purple centre. Serology testing showed acute HBV infection, and a biopsy revealed a superficial and interstitial perivascular inflammatory infiltrate of lymphocytes and eosinophils...
October 20, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27742137/-uncommon-cutaneous-presentation-of-visceral-leishmaniasis-associated-with-hiv
#12
C Cossart, G Le Moal, M Garcia, E Frouin, E Hainaut-Wierzbicka, F Roblot
BACKGROUND: Visceral leishmaniasis is not normally expressed in skin. Herein, we describe the case of an HIV-positive patient who developed two unusual skin manifestations during an episode of visceral leishmaniasis. PATIENTS AND METHODS: A 48-year-old female patient consulted initially for infiltrated purpura of all four limbs. Skin biopsy revealed leukocytoclastic vasculitis with Leishman-Donovan bodies. Laboratory tests showed medullary, splenic, gastric and colic involvement, suggesting systemic disease, and enabling visceral leishmaniasis to be diagnosed...
October 11, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27739125/toxic-epidermal-necrolysis-induced-by-vemurafenib-after-nivolumab-failure
#13
M Arenbergerova, I Mrazova, J Horazdovsky, E Sticova, A Fialova, P Arenberger
Vemurafenib is a selective inhibitor of the BRAF-kinase approved for the treatment of metastatic melanoma harboring BRAF mutation. Skin toxicity, including maculopapular exanthema, photosensitivity and keratoacanthoma, are the most common treatment-related adverse events of vemurafenib, affecting more than 90% of patients (1,2). It rarely presents with intense severity, with less than 1% of grade-4 toxicities reported in clinical trials (3,4). This article is protected by copyright. All rights reserved.
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27717583/-febrile-exanthema-in-french-guyana
#14
F Morin, F de Laval, J-J Morand
No abstract text is available yet for this article.
October 4, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27712573/diagnosing-%C3%AE-lactam-hypersensitivity
#15
Francesco Gaeta, Maria J Torres, Rocco Luigi Valluzzi, Cristiano Caruso, Cristobalina Mayorga, Antonino Romano
Hypersensitivity reactions to β-lactam antibiotics are commonly reported. They can be classified as immediate or non-immediate according to the time interval between the last drug administration and their onset. Immediate reactions occur within one hour after the last drug administration and are manifested clinically by urticaria and/or angioedema, rhinitis, bronchospasm, and anaphylactic shock; they may be mediated by specific IgE-antibodies. Non-immediate reactions occur more than one hour after the last drug administration...
October 4, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27658762/efficacy-and-safety-of-canakinumab-in-schnitzler-s-syndrome-a-multi-center-randomized-placebo-controlled-study
#16
Karoline Krause, Athanasios Tsianakas, Nicola Wagner, Jörg Fischer, Karsten Weller, Martin Metz, Martin K Church, Marcus Maurer
BACKGROUND: Schnitzler's syndrome is an adult-onset autoinflammatory disease characterized by urticarial exanthema and monoclonal gammopathy accompanied by systemic symptoms such as fever, bone and muscle pain. Up to now, approved treatment options are not available. OBJECTIVE: We here assessed the effects of the anti-IL-1ß monoclonal antibody canakinumab on the clinical signs and symptoms of Schnitzler's syndrome. METHODS: In this phase II, randomized placebo-controlled multi-center study, 20 patients with active disease enrolled in four German study centers...
September 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27539949/the-first-identification-and-complete-genome-of-senecavirus-a-affecting-pig-with-idiopathic-vesicular-disease-in-china
#17
Q Wu, X Zhao, Y Bai, B Sun, Q Xie, J Ma
Senecavirus A (SVA) infection was recently confirmed in pigs in Brazil. In March, 2015, an outbreak of vesicular disease occurred in Guangdong, China, characterized by vesicular lesions in sows and acute death of neonatal piglets. Cumulative incidence of porcine idiopathic vesicular disease in farm A was 258, which had a total number of 5500 sows. Sows in farm B displayed typical vesicular symptoms by May, 2015, which also had 5500 sows. A total of 278 and 142 of 5500 sows in farm B demonstrated lame and presented vesicles, respectively, associated with a total of 186 mortality in piglets...
August 18, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27522939/-venous-thrombosis-unrecognized-complication-of-dress
#18
F Medhioub Kaaniche, R Allela, N Ben Algia, S Cherif, M Attar, I Frikha, M Mnif
BACKGROUND: DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) is a rare syndrome triggered by an immunological reaction to certain drugs and which may be life-threatening as a result of the onset of severe organ involvement. It is characterised by a long period from the time of drug therapy to the onset of actual signs. Herein, we report the case of 42-year-old female patient who developed DRESS one month after beginning allopurinol treatment. PATIENTS AND METHODS: A 42-year-old woman was hospitalised for febrile exanthema with facial oedema, polyadenopathy, mononucleosis syndrome, major hypereosinophilia and hepatic cytolysis...
August 11, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27505281/molecular-epidemiology-of-enterovirus-and-parechovirus-infections-according-to-patient-age-over-a-4-year-period-in-spain
#19
María Cabrerizo, María Díaz-Cerio, Carmen Muñoz-Almagro, Núria Rabella, David Tarragó, María Pilar Romero, María José Pena, Cristina Calvo, Sonia Rey-Cao, Antonio Moreno-Docón, Inés Martínez-Rienda, Almudena Otero, Gloria Trallero
The epidemiology and clinical association of enterovirus (EV) and parechovirus (HPeV) infections, as well as the type-distribution-according-to-age, were determined during a 4-year study period in Spain. During 2010-2013, a total of 21,832 clinical samples were screened for EV and the detection frequency was 6.5% (1,430). Of the total EV-negative samples, only 1,873 samples from 2011 to 2013 were available for HPeV testing. HPeV was detected in 42 (2%) of them. Positive samples were genotyped using PCR and sequencing...
August 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27497618/serum-tarc-levels-are-strongly-correlated-with-blood-eosinophil-count-in-patients-with-drug-eruptions
#20
Takayoshi Komatsu-Fujii, Sakae Kaneko, Yuko Chinuki, Yohji Suyama, Masataka Ohta, Hiroyuki Niihara, Eishin Morita
BACKGROUND: This study aims to evaluate the relationship between serum thymus and activation-regulated chemokine (TARC) levels with various clinicopathological conditions in patients with drug eruptions. The value of TARC in diagnosing drug-induced hypersensitivity syndrome (DIHS) was also examined. METHODS: Study participants included 84 patients who presented with generalized eruptions suspected to be drug-related, including DIHS, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), maculopapular exanthema (MPE), erythema multiforme (EM), erythroderma, and toxicoderma...
August 4, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
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