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https://www.readbyqxmd.com/read/29905966/chromosomally-integrated-human-herpesvirus-6-in-the-japanese-population
#1
Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Kei Kozawa, Masaru Ihira, Tamae Ohye, Hiroki Kurahashi, Tetsushi Yoshikawa
OBJECTIVES: To elucidate an incidence and virological findings of chromosomally integrated human herpesvirus 6 (ciHHV-6) in Japanese population and analyzed an association between ciHHV-6 and a clinical manifestation of exanthema subitum (ES). METHODS: Real-time PCR was performed to determine HHV-6 DNA loads in 2347 cord blood samples from healthy neonates (cohort A), febrile children less than 5 years old (cohort B), and hematopoietic cell transplant recipients (cohort C)...
June 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29785130/human-herpesvirus-6-pneumonitis-in-a-patient-with-follicular-lymphoma-following-immunochemotherapy-with-rituximab
#2
Saeko Kuwahara-Ota, Yoshiaki Chinen, Yoshimi Mizuno, Tomoko Takimoto-Shimomura, Yayoi Matsumura-Kimoto, Kazuna Tanba, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Junya Kuroda
Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29782922/dengue-chikungunya-and-zika-infections-imported-to-paris-between-2009-and-2016-characteristics-and-correlation-with-outbreaks-in-the-french-overseas-territories-of-guadeloupe-and-martinique
#3
Victor Vasquez, Elie Haddad, Alice Perignon, Stéphane Jaureguiberry, Ségolène Brichler, Isabelle Leparc-Goffart, Eric Caumes
BACKGROUND: Dengue (DV), chikungunya (CV) and Zika virus (ZV) infections are rapidly expanding across countries and diagnosed in returned travelers who represent epidemiological sentinels. French Territories of America (FTA) such as Guadeloupe and Martinique are highly touristic places and have experienced three consecutive outbreaks by such viruses in the last decade. OBJECTIVE: We evaluated how ill returned travelers could be deemed as epidemiological sentinels for these three expanding arboviral diseases during eight consecutive years...
May 18, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#4
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29779880/in-vitro-comparison-of-acyclovir-ganciclovir-and-cidofovir-against-equid-alphaherpesvirus-3-and-evaluation-of-their-efficacy-against-six-field-isolates
#5
María A Vissani, Osvaldo Zabal, María S Tordoya, Viviana Parreño, Etienne Thiry, María Barrandeguy
Equid alphaherpesvirus 3 (EHV3) is the etiological agent of equine coital exanthema (ECE), which is a venereal, highly contagious disease, characterized by the formation of papules, vesicles, pustules and ulcers on the external genitalia of mares and stallions. EHV3 remains in a latent state after a successful infection and there are latently infected animals in which the virus is reactivated and generally re-excreted subclinically. There are no available vaccines for this condition and prevention is based on the clinical examination of mares prior to mating, which allows to segregate those showing clinical signs...
May 17, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29774022/acute-zika-virus-infection-in-an-endemic-area-shows-modest-proinflammatory-systemic-immunoactivation-and-cytokine-symptom-associations
#6
Jéssica Barletto de Sousa Barros, Paulo Alex Neves da Silva, Rosemary de Carvalho Rocha Koga, Patrícia Gonzalez-Dias, José Rodrigues Carmo Filho, Patrícia Resende Alo Nagib, Verônica Coelho, Helder I Nakaya, Simone Gonçalves Fonseca, Irmtraut Araci Hoffmann Pfrimer
An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29766368/systemic-contact-dermatitis
#7
REVIEW
Marcella Aquino, Greg Rosner
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29731498/a-case-of-anti-glomerular-basement-membrane-antibody-positive-systemic-lupus-erythematosus-with-pulmonary-hemorrhage-successfully-treated-at-an-early-stage-of-the-disease
#8
Takehisa Yamada, Koji Mugishima, Seiichiro Higo, Yukie Yoshida, Fumiaki Itagaki, Shizuka Yui, Tetsuya Kashiwagi, Yoko Endo, Akira Shimizu, Shuichi Tsuruoka
We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum creatinine...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29724618/missed-opportunities-in-the-diagnosis-of-human-immunodeficiency-virus-infection-in-the-region-of-aragon-late-diagnosis-importance
#9
César Gargallo-Bernad, Francisco Javier Sangrós-González, Piedad Arazo-Garcés, Rosa Martínez-Álvarez, Carmen Malo-Aznar, Alicia Gargallo-Bernad, Alba Ballester-Luna, Luis Eduardo Cabrero-Pascual, Pablo Gil-Orna, Víctor José Abadía-Gallego, Isabel Torres-Peña, Héctor Ordiz-Suárez
INTRODUCTION: Late Diagnosis (LD) of Human Immunodeficiency Virus (HIV) infection (CD4 lymphocytes <350/μl at diagnosis of the disease), deteriorates the condition of those affected and increases the probability of transmission. The objective of the present study was to analyse the prevalence of LD, to identify missed diagnostic opportunities (MDO) and to find out which level of the health care delivery system they took place. METHODS: Retrospective, observational and descriptive study of the population diagnosed with infection of HIV/AIDS in the period 2011-2015 in Aragon...
April 30, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29722025/tacrolimus-induced-symmetric-drug-related-intertriginous-and-flexural-exanthema-sdrife
#10
Maria Scherrer, Marcelo G Araujo, Katia Farah
No abstract text is available yet for this article.
June 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29690993/-drug-eruption
#11
Ali Tareen, Anette Bygum
Drug eruption is defined as an adverse cutaneous eruption secondary to drug intake. The most frequent variation is a morbilliform exanthema, although the clinical presentations may vary widely. The diagnosis is clinical, why thorough medical history and assessment are essential for the risk stratification of possible adverse cutaneous reaction. In Western hospitals, the prevalence is estimated to be 2-3% of the patients. Identification of the condition is therefore important for all healthcare professionals...
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29674359/relapsing-pityriasis-rosea-with-hhv-7-reactivation-in-an-11-year-old-girl
#12
Ilka Engelmann, Judith Ogiez, Lucie Ogiez, Enagnon Kazali Alidjinou, Mouna Lazrek, Anny Dewilde, Didier Hober
Pityriasis rosea (PR) usually presents as acute exanthema with oval erythematous-squamous lesions localized on the trunk, arms, and legs with spontaneous remission. We present an unusual case of PR with frequent relapses during a period of 7 years. An 11-year-old white female patient presented with many pruritic erythematous oval lesions on her trunk. A second episode followed 2 years later with several pruritic erythematous lesions on her lower limbs. During the following 5 years, the patient had several relapses per year, with 1 to 3 lesions on changing localizations...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29661742/overlap-between-dress-syndrome-and-exanthema-induced-by-sulfadiazine-in-a-patient-treated-with-sulfamethoxazole-utility-of-the-lymphocyte-transformation-test-for-identification-of-the-culprit-drug
#13
O P Monge-Ortega, R Cabañas, A Fiandor, J Domínguez-Ortega, M González-Muñoz, S Quirce, M Lluch-Bernal, T Bellón
No abstract text is available yet for this article.
April 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29651444/an-updated-review-of-the-molecular-mechanisms-in-drug-hypersensitivity
#14
REVIEW
Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung
Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29644421/-infections-after-bite-wounds-for-example-rat-bite-fever-due-to-streptobacillus-moniliformis
#15
Herbert Hof, Rudolf Binder, Christian Schäfer, Madeleine Stuber, Andreas Licht, Iris Bozenhardt-Stavrakidis, Konrad Bode
Rat bite fever due to Streptobacillus moniliformis induces typical but not pathognomonic clinical signs, such as local purulent wound infection followed by maculopapular exanthema, myalgia as well as purulent joint infections. Severe complications, such as osteomyelitis and endocarditis are possible. it seems that this infection is rarely diagnosed but this infection could be much more common because the final diagnostic proof is difficult to achieve. Firstly, the culture of these bacteria is critical because the bacteria are fastidious and secondly the exact differentiation of the isolates is hardly possible by standard laboratory methods...
April 11, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29627335/on-site-detection-of-equid-alphaherpesvirus-3-in-perineal-and-genital-swabs-of-mares-and-stallions
#16
M A Vissani, M S Tordoya, Y-L Tsai, P-Y A Lee, Y-H Shen, F-C Lee, H-T T Wang, V Parreño, M Barrandeguy
Equine coital exanthema (ECE) is an infectious, venereally transmitted muco-cutaneous disease affecting mares and stallions, caused by equid alphaherpesvirus 3 (EHV3). Diagnostic tools for rapid identification of EHV3 are of primary importance to diminish the risk of EHV3 dissemination at the time of breeding. In the last years, it has been shown that the performance of the insulated-isothermal polymerase chain reaction (iiPCR) is comparable to virus isolation, nested PCR and real-time PCR (qPCR) in detecting pathogens of various animal species...
July 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29600426/antibiotic-induced-fever-in-orthopaedic-patients-a-diagnostic-challenge
#17
Kirsten Labbus, Jana Karina Junkmann, Carsten Perka, Andrej Trampuz, Nora Renz
INTRODUCTION: Antibiotic-induced fever is a probably underestimated complication, which may be misdiagnosed as new infection. In this study, characteristics, diagnostic approach, and outcome of antibiotic-induced fever in patients treated for musculoskeletal infections are described. METHODS: We retrospectively reviewed all patients with antibiotic-induced fever after surgery treated at our institution from 2014 to 2017. Antibiotic-induced fever was diagnosed, if the following criteria were fulfilled: (i) central (ear) body temperature > 38...
March 29, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29582466/unique-cell-tropism-of-hhv-6b-in-an-infantile-autopsy-case-of-primary-hhv-6b-encephalitis
#18
Hiroaki Miyahara, Kouki Miyakawa, Haruto Nishida, Shinji Yano, Tomoko Sonoda, So-Ichi Suenobu, Tatsuro Izumi, Tsutomu Daa, Kenji Ihara
Human herpes virus 6 (HHV-6) is known to cause primary encephalitis in the frontal lobes/cerebral hemisphere or reactivated encephalitis in the hippocampus, but the pathogenesis remains unclear. HHV-6B has also been detected in hippocampal samples in patients with mesial temporal lobe epilepsy. A 1 year and 3 months old female, who had been clinically diagnosed with exanthema subitum and febrile convulsion, was found dead on the third day after onset. Macroscopic findings showed massive brain edema. Microscopic examination revealed gemistocytic astrocytes and ballooned oligodendrocytes in the frontal white matter, along with neuronal cell death with microglial infiltration in the frontal cortex...
March 26, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29558524/survival-of-viral-pathogens-in-animal-feed-ingredients-under-transboundary-shipping-models
#19
Scott A Dee, Fernando V Bauermann, Megan C Niederwerder, Aaron Singrey, Travis Clement, Marcelo de Lima, Craig Long, Gilbert Patterson, Maureen A Sheahan, Ana M M Stoian, Vlad Petrovan, Cassandra K Jones, Jon De Jong, Ju Ji, Gordon D Spronk, Luke Minion, Jane Christopher-Hennings, Jeff J Zimmerman, Raymond R R Rowland, Eric Nelson, Paul Sundberg, Diego G Diel
The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV)...
2018: PloS One
https://www.readbyqxmd.com/read/29557985/isolation-of-infectious-zika-virus-from-a-urine-sample-cultured-in-sirc-cells-from-a-patient-suspected-of-having-rubella-virus
#20
Maria Isabel de Oliveira, Gislene Mitsue Namiyama, Gabriela Bastos Cabral, João Leandro Ferreira, Noemi Taniwaki, Ana Maria Sardinha Afonso, Isabella Rillo Lima, Luís Fernando Macedo de Brigido
A great variety of viruses which cause exanthema share other clinical manifestations, making the etiologic identification a very difficult task, relying exclusively on the clinical examination. Rubella virus (RV) infection during the early stages of pregnancy can lead to serious birth defects, known as congenital rubella syndrome (CRS). In the present report, we described the presence of Zika virus (ZIKV) particles in urine samples and also ZIKV isolation in SIRC cells from the urine of a patient in acute phase of suspected rubella disease...
2018: Revista do Instituto de Medicina Tropical de São Paulo
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