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https://www.readbyqxmd.com/read/29027615/assessment-of-the-role-of-everolimus-therapy-in-patients-with-renal-cell-carcinoma-based-on-daily-routine-and-recent-research-results
#1
Anikó Maráz, András Csejtei, Judit Kocsis, Miklós Szűcs, Zsuzsanna Kahán, György Bodoky, Magdolna Dank, László Mangel, János Révész, Zoltán Varga, Lajos Géczi
Everolimus is indicated for adults with metastatic renal cell carcinoma (mRCC) after failure of vascular endothelial growth factor receptor-tyrosine kinase inhibitors (TKI). Currently, the therapeutic applicability of EVE has been changing. Multicenter evaluation of efficacy and safety of everolimus in daily routine and definition of patient characteristics with favorable outcome. Data of 165 patients from 9 oncology institutes in Hungary were analyzed retrospectively. Everolimus therapy was used after one TKI in 10 mg starting dose...
October 13, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29024017/most-common-dermatology-diagnoses-to-the-emergency-department-in-the-pediatric-population
#2
Anish Nadkarni, Leah A Cardwell, Simon Mahler, Steven R Feldman
Skin related complaints are a top 10 reason for pediatric presentation to the ED. Older studies and those conducted outside of the US demonstrate wide variability in the frequency of pediatric presentations to the ED for skin complaints, ranging from 4-40% of visits.(1) One study found urticaria to be the most frequent PED dermatological diagnosis, while others found viral exanthema and contact dermatitis to be the most common diagnoses. This article is protected by copyright. All rights reserved.
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28979629/-approach-to-the-diagnosis-of-patients-with-febrile-rash
#3
Nadia Fihmi, Imane Alouani, Abdelhafid Elmrahi, Nada Zizi, Siham Dikhaye
The patient with febrile rash poses a real diagnostic challenge to primary care physician. We report an original case of febrile macular rash whose etiology was related to sepsis secondary to pelviperitonitis and acute cholecystitis. Patient's history, careful physical examination, paraclinical examinations and favorable outcome allowed to retain the infectious origin of the rash, without microbiological confirmation in our study. The skin is an excellent marker for infection. Cutaneous manifestations are the most common signs observed in patients with sepsis at an early stage...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28937434/th17-response-of-borderline-lepromatous-leprosy-inhibits-rash-manifestation-of-dapsone-hypersensitivity-syndrome-case-report
#4
Tamara de Nardo Vanzela, Fred Bernardes Filho, Carlos Gustavo Wambier, Francesca Maia Faria, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. OBJECTIVE: Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. METHODS: The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28902271/-clinical-and-epidemiological-characterization-of-chikungunya-fever-in-mexico
#5
Carolina Garay-Morán, Juan Francisco Román-Pedroza, Irma López-Martínez, José Cruz Rodríguez-Martínez, Cuitláhuac Ruiz-Matus, Pablo Kuri-Morales, José Alberto Díaz-Quiñonez
On 6 December 2013, the Pan American Health Organization (PAHO) and the World Health Organization (WHO) reported confirmation of the first two cases of indigenous transmission of chikungunya fever (CHIK) in the Region of the Americas on the island of Sint Maarten (Netherlands Antilles). For the period 2013-2014, a total of 25 627 confirmed autochthonous cases were distributed in 43 countries, with Mexico reporting 155 cases in five states. Information on cases of CHIK in Mexico was obtained from the database of the General Directorate of Epidemiology (Ministry of Health of Mexico)...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28810279/-severe-yellow-fever-vaccine-associated-disease-a-case-report-and-current-overview
#6
Günther Slesak, Martin Gabriel, Cristina Domingo, Johannes Schäfer
History and physical examination A 56-year-old man developed high fever with severe headaches, fatigue, impaired concentration skills, and an exanthema 5 days after a yellow fever (YF) vaccination. Laboratory tests Liver enzymes and YF antibody titers were remarkably elevated. YF vaccine virus was detected in urine by PCR. Diagnosis and therapy Initially, severe YF vaccine-associated visceral disease was suspected and treated symptomatically. Clinical Course His fever ceased after 10 days in total, no organ failure developed...
August 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28798699/schizophrenia-or-atypical-lupus-erythematosus-with-predominant-psychiatric-manifestations-over-25%C3%A2-years-case-analysis-and-review
#7
Axel Mack, Christiane Pfeiffer, E Marion Schneider, Karl Bechter
We observed a case over 25 years of relapsing-remitting schizophrenic spectrum disorder, varying regarding the main symptomatology between more depressive or more schizoaffective or rather typical schizophrenic syndrome. Diseased phases were repeatedly accompanied by minor skin lesions, which were initially classified as mixed tissue disorder. Psychotic phases were waxing-waning over years. During one later relapse, skin involvement was severe, classified to likely represent an allergic reaction to psychopharmaca; this generalized exanthema remitted rapidly with cortisone treatment and azathioprine...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28769893/imported-zika-virus-in-a-european-city-how-to-prevent-local-transmission
#8
Joan-Pau Millet, Tomàs Montalvo, Ruben Bueno-Marí, Arancha Romero-Tamarit, Albert Prats-Uribe, Lidia Fernández, Esteve Camprubí, Lucía Del Baño, Victor Peracho, Jordi Figuerola, Elena Sulleiro, Miguel J Martínez, Joan A Caylà
Background: On February 1st 2016 the WHO declared the Zika Virus (ZIKV) infection a worldwide public health emergency because of its rapid expansion and severe complications, such as Guillain-Barré Syndrome or microcephaly in newborn. The huge amount of people traveling to endemic areas and the presence of Aedes albopictus in Barcelona increase the risk of autochtonous transmission. The objective of this study was to describe the first ZIKV cases diagnosed in our city and to analyze the surveillance, prevention, and control measures implemented to avoid autochthonous transmission...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28754229/-hypersensitivity-reactions-to-beta-lactam-antibiotics
#9
E Amsler, A Soria
Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated. Two types of allergy should be distinguished and include immediate hypersensitivity that can lead to anaphylactic shock and delayed hypersensitivity, ranging from the most common maculopapular exanthema to severe bullous toxidermia or life-threatening DRESS. Allergy challenge with oriented skin tests according to the clinical features, supplemented with oral challenge in the absence of contraindication, will confirm or invalidate the diagnosis of beta-lactam allergy and will help to identify if necessary safe alternatives to beta-lactams...
July 25, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28752367/update-on-quinolone-allergy
#10
REVIEW
Inmaculada Doña, Esther Moreno, Natalia Pérez-Sánchez, Inmaculada Andreu, Dolores Hernández Fernandez de Rojas, María José Torres
PURPOSE OF REVIEW: Quinolones are a group of synthetic antibiotics widely use as first-line treatment for many infections. There has been an increase in the incidence of hypersensitivity reactions to quinolones in recent years, likely due to increased prescription. The purpose of this review is to summarize the clinical pictures, the methods used for diagnosing and the management of allergic reactions to quinolones. RECENT FINDINGS: Allergic reactions to quinolones can be immediate or delayed, being anaphylaxis and maculopapular exanthema respectively the most frequent clinical entities...
August 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28744306/prevalence-and-clinical-profile-of-drug-eruptions-among-antiretroviral-therapy-exposed-hiv-infected-people-in-yaound%C3%A3-cameroon
#11
Emmanuel Armand Kouotou, Jobert Richie Nansseu, Vanessa Nancy Ngono, Sandra A Tatah, Anne Cecile Zoung-Kanyi Bissek, Elie Claude Ndjitoyap Ndam
BACKGROUND: Prevalence and incidence of drug eruptions vary around the world and are influenced by some key factors including HIV infection. OBJECTIVE: This study aimed to find the peculiarities of drug eruptions in people living with HIV (PLHIV) and on antiretroviral therapy (ART). METHODS: This was a retrospective cross-sectional study including ART-taking PLHIV, aged 15+ years, followed up between January 2010 and December 2014 at the day-care unit of the Yaoundé Central Hospital, and who presented with drug eruptions after ART initiation...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28730261/post-medication-stevens-johnson-syndrome-in-a-girl-hospitalized-for-a-norovirus-and-rotavirus-infection
#12
Simona Dumitra, LuminiŢa Pilat, Alina Iftode, Ozana Nicoleta Bălan, Carmen Ramona StănculeŢ, Elena Claudia Covaci, Alexandru Fica Mircea Onel, Carmen Nicoleta Crişan
Stevens-Johnson syndrome (SJS) is a cutaneous mucosal disorder characterized by extended necrosis and detachment of the epidermis affecting <10% of the body surface, caused by drugs or infections. The authors report a case of a girl with Depakine resistant epilepsy, who develops a SJS in the third week of introducing lamotrigine. The girl also presents an acute diarrheal disease with double viral etiology - rotavirus and norovirus. The clinical image comprises polymorphic erythematous maculopapular exanthema with vesicular and bullous elements, with ulcerations and desquamations at the level of the eyelids, mouth, anogenital area and tegument denuding at the level of the abdomen and limbs...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28728872/oropharyngeal-lesions-in-pityriasis-rosea
#13
Giulia Ciccarese, Francesco Broccolo, Alfredo Rebora, Aurora Parodi, Francesco Drago
BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28704988/acute-generalized-exanthema-tous-pustulosis-agep-associated-to-epstein-barr-virus-ebv-infection-reactivation
#14
Simona Giancristoforo, Andrea Diociaiuti, Diana Mennis, Cristina Rota, Cristina Russo, Luana Coltella, Mauro Paradisi, May El Hachem
No abstract text is available yet for this article.
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28700372/immunohistochemical-demonstration-of-parvovirus-b19-viral-protein-2-in-periflexural-exanthema-in-an-adult-supporting-antibody-dependent-enhancement-as-means-of-endothelial-uptake-of-the-virus
#15
Carlos Santonja, Úrsula Pielasinski, Jorge Polo, Heinz Kutzner, Luis Requena
Human parvovirus B19 (B19V) causes a number of skin exanthemas and has been related to both cutaneous and systemic diseases. Tropism of the virus for the rapidly proliferating erythroid progenitor cells in the bone marrow and fetal liver explains the pathogenesis of anemia and fetal hydrops. The cutaneous lesions of erythema infectiosum and other B19V-related exanthemas have been attributed to the deposition of immune complexes in the skin. We report on the immunohistochemical detection of B19V protein in the cytoplasm of dermal endothelial cells in a case of periflexural exanthema in a 28-year-old woman...
July 6, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28698724/hla-b-1502-in-iranian-children-with-anticonvulsant-drugs-induced-skin-reactions
#16
Seyed Hasan Tonekaboni, Narjes Jafari, Mahboubeh Mansouri, Sayena Jabbehdari, Rahil Eftekhari, Zahra Chavoshzadeh, Fatemeh Abdollah Gorji, Mehrnaz Mesdaghi
OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28677584/cutaneous-drug-reactions-annular-polycyclic-erythematous-exanthema-in-an-oncology-patient
#17
Ignacio Hernandez-Aragues, Ofelia Baniandrés-Rodríguez, José Antonio Avilés-Izquierdo, Pedro Tiago Vilas-Boas
No abstract text is available yet for this article.
June 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28669649/-dress-syndrome-and-agranulocytosis-a-rare-combination
#18
P Lavenant, J-M Roue, F Huet, C Abasq, L Misery, S Rioualen
INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe toxidermia that can lead to death from multivisceral failure. We report a case of DRESS associated with febrile agranulocytosis in a child. OBSERVATION: An 8-year-old child was hospitalized for diffuse maculopapular exanthema with edema of the extremities and face associated with cheilitis and febrile agranulocytosis. This symptomatology began 1month after the introduction of carbamazepine for partial epilepsy...
June 29, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28656474/dissecting-kawasaki-disease-a-state-of-the-art-review
#19
REVIEW
S M Dietz, D van Stijn, D Burgner, M Levin, I M Kuipers, B A Hutten, T W Kuijpers
Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. The diagnosis is based on the presence of persistent fever and clinical features including exanthema, lymphadenopathy, conjunctival injection, and changes to the mucosae and extremities. Although the etiology remains unknown, the current consensus is that it is likely caused by an (infectious) trigger initiating an abnormal immune response in genetically predisposed children. Treatment consists of high dose intravenous immunoglobulin (IVIG) and is directed at preventing the development of CAA...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28648978/the-thymus-and-activation-regulated-chemokine-tarc-level-in-serum-at-an-early-stage-of-a-drug-eruption-is-a-prognostic-biomarker-of-severity-of-systemic-inflammation
#20
Takayoshi Komatsu-Fujii, Yuko Chinuki, Hiroyuki Niihara, Kenji Hayashida, Masataka Ohta, Ryota Okazaki, Sakae Kaneko, Eishin Morita
BACKGROUND: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. The aim of this study was to test whether the thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption can serve as a prognostic biomarker of systemic inflammation...
June 22, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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