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https://www.readbyqxmd.com/read/29353463/protective-effect-of-a-newly-developed-fucose-deficient-recombinant-antithrombin-against-histone-induced-endothelial-damage
#1
Toshiaki Iba, Tatsuhiko Hirota, Koichi Sato, Isao Nagaoka
Antithrombin is expected to modulate both prothrombotic and proinflammatory reactions in sepsis; vascular endothelium is the primary target. In the present study, we sought to evaluate the protective effects of a newly developed fucose-deficient recombinant antithrombin. Endothelial cells were treated in vitro with histone H4 to induce cellular damage. Low to high doses of either plasma-derived antithrombin or recombinant thrombomodulin were used as treatment interventions. Morphological change, apoptotic rate, cell viability, cell injury, and syndecan-4 level in the medium were evaluated...
January 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29353438/examination-of-pituitary-adenylate-cyclase-activating-polypeptide-pacap-as-a-potential-biomarker-in-heart-failure-patients
#2
Zsolt Sarszegi, Dora Szabo, Balazs Gaszner, Attila Konyi, Dora Reglodi, Jozsef Nemeth, Beata Lelesz, Beata Polgar, Adel Jungling, Andrea Tamas
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated its cardioprotective effects in vitro and in various animal models. However, few data are available on the presence of PACAP in human cardiac tissues and its role in the pathomechanism and progression of different cardiac disorders, particularly heart failure...
January 20, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29353393/131i-induced-graves-disease-in-patients-treated-for-toxic-multinodular-goitre-systematic-review-and-descriptive-analysis
#3
REVIEW
C Roque, C A Vasconcelos
BACKGROUND: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes. METHODS: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (131I-IGD) in adults...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29353215/sparks-fly-between-ascorbic-acid-and-iron-based-nanozymes-a-study-on-prussian-blue-nanoparticles
#4
Wei Zhang, Yang Wu, Hai-Jiao Dong, Jun-Jie Yin, Hui Zhang, Hao-An Wu, Li-Na Song, Yu Chong, Zhuo-Xuan Li, Ning Gu, Yu Zhang
Herein we reported Prussian blue nanoparticles (PBNPs) possess ascorbic acid oxidase (AAO)- and ascorbic acid peroxidase (APOD)-like activities, which suppressed the formation of harmful H2O2 and finally inhibited the anti-cancer efficiency of ascorbic acid (AA). This newly revealed correlation between iron and AA could provide new insight for the studies of nanozymes and free radical biology.
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29353206/dihydroartemisinin-ameliorates-sepsis-induced-hyperpermeability-of-glomerular-endothelium-via-up-regulation-of-occludin-expression
#5
Zuowang Cheng, Ruixia Qi, Liqun Li, Qiang Liu, Wenqian Zhang, Xia Zhou, Dongmei Xu, Thaddeus D Allen, Silin Pan, Ju Liu
Sepsis, the systemic inflammatory responses after infection, remains a serious cause of morbidity and mortality in critically ill patients. The anti-malarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we examined the effects of DHA on sepsis-induced acute kidney injury (AKI) and explored the mechanism underlying its mode of action in AKI. In a lipopolysaccharide (LPS)-induced mouse model, we observed that DHA treatment ameliorated glomerular injury, and relieved elevation of the urine albumin to creatinine ratio (UACR) and serum creatinine...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29353205/wisp3-prevents-fibroblast-myofibroblast-transdifferentiation-in-nrk-49f-cells
#6
Yang Yi, Jun Ma, Lu Jianrao, Hangqing Wang, Yingdan Zhao
CCN family, a group of six extracellular matrix-associated proteins, plays an important role in fibrosis. WISP3 has addressed as a pro-fibrotic molecule in the development of human lung fibrosis. However, whether WISP3 involved in the activation and proliferation of renal fibroblast, and ultimately inhibited fibroblast-myofibroblast transdifferentiation remained unknown. Herein, we found that down-regulated WISP3 was involved in the fibrogenesis of rat renal NRK-49F cells induced by transforming growth (TGF-β1), which was further confirmed in a rat renal fibrosis induced by unilateral ureteral obstruction (UUO)...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29353157/phytochemical-analysis-of-salal-berry-gaultheria-shallon-pursh-a-traditionally-consumed-fruit-from-western-north-america-with-exceptionally-high-proanthocyanidin-content
#7
Andrew Ferguson, Elisabete Carvalho, Geraldine Gourlay, Vincent Walker, Stefan Martens, Juha-Pekka Salminen, C Peter Constabel
Salal (Gaultheria shallon Pursh.) is a wild perennial shrub of the Ericaceae and common in coastal forests of western North America, and its berries were an important traditional food for First Nations in British Columbia. Salal berries were investigated for phytochemical content and antioxidant capacity over the course of fruit development. The proanthocyanidin content was extremely high in young berries (280.7 mg/g dry wt) but dropped during development to 52.8 mg/g dry wt. By contrast, anthocyanins accumulated only at the late berry stages...
January 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29353140/development-of-sea-bream-sparus-aurata-semen-vitrification-protocols
#8
Loredana Zilli, Annalisa Bianchi, Maroua Sabbah, Laura Pecoraro, Roberta Schiavone, Sebastiano Vilella
The long-term goal of this research project is to set up efficient protocol that can be used to develop a standardized approach for vitrification of marine fish spermatozoa. In particular, the aim of the present study was to develop a vitrification protocol for sea bream (Sparus aurata) spermatozoa. To draw up the protocol, we tested two different dilution media (1% NaCl and Mounib medium), three different vitrification devices (loops, drops and cut straws), different cryoprotectants (CPs) and three different equilibration times (30, 60 and 120 s)...
January 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29353098/the-anti-inflammatory-effects-of-statins-on-patients-with-rheumatoid-arthritis-a-systemic-review-and-meta-analysis-of-15-randomized-controlled-trials
#9
REVIEW
Guo-Min Li, Jie Zhao, Bing Li, Xiao-Fei Zhang, Jian-Xiong Ma, Xin-Long Ma, Jun Liu
BACKGROUND: Over the past several years, numerous studies investigated the anti-inflammatory effects of statin on patients with RA. However, the findings of the individual studies were often inconsistent or conflicting. MATERIALS AND METHODS: The Pubmed, Web of Science, Embase, Cochrane Library and CNKI literature databases were searched in order to identify randomized controlled clinical trials where the association between the anti-inflammatory effect of statin and RA was investigated...
January 15, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29353086/ruthenium-dendrimers-as-carriers-for-anticancer-sirna
#10
Sylwia Michlewska, Maksim Ionov, Marta Maroto-Díaz, Aleksandra Szwed, Aliaksei Ihnatsyeu-Kachan, Svetlana Loznikova, Dzmitry Shcharbin, Marek Maly, Rafael Gomez Ramirez, Francisco Javier de la Mata, Maria Bryszewska
Dendrimers, which are considered as one of the most promising tools in the field of nanobiotechnology due to their structural organization, showed a great potential in gene therapy, drug delivery, medical imaging and as antimicrobial and antiviral agents. This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence...
January 12, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29353079/expression-and-functional-characterization-of-transferrin-in-nile-tilapia-oreochromis-niloticus-in-response-to-bacterial-infection
#11
Xiaoxue Yin, Liangliang Mu, Xia Bian, Liting Wu, Bingxi Li, Jing Liu, Zheng Guo, Jianmin Ye
Transferrin (TF), an iron-binding glycoprotein, plays an important role in host defense against pathogenic infection, which inhibits the growth and proliferation of pathogens, deprives iron from invading pathogens, and activates anti-microbial responses in macrophages. In this study, a TF homologue (OnTF) was identified from Nile tilapia (Oreochromis niloticus) and characterized at expression pattern against bacterial infection and capability binding bacterial pathogens. The open reading frame of OnTF is 2118 bp of nucleotide sequence encoding polypeptides of 705 amino acids...
January 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29353071/effects-of-warfarin-on-biological-processes-other-than-haemostasis-a-review
#12
REVIEW
Aleksandra Popov Aleksandrov, Ivana Mirkov, Marina Ninkov, Dina Mileusnic, Jelena Demenesku, Vesna Subota, Dragan Kataranovski, Milena Kataranovski
Warfarin is the world's most widely used anticoagulant drug. Its anticoagulant activity is based on the inhibition of the vitamin K-dependent (VKD) step in the complete synthesis of a number of blood coagulation factors that are required for normal blood coagulation. Warfarin also affects synthesis of VKD proteins not related to haemostasis including those involved in bone growth and vascular calcification. Antithrombotic activity of warfarin is considered responsible for some aspects of its anti-tumour activity of warfarin...
January 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29353050/helicobacter-pylori-infection-an-update-for-the-internist-in-the-age-of-increasing-global-antibiotic-resistance
#13
REVIEW
Osama Siddique, Anais Ovalle, Ayesha S Siddique, Steven F Moss
Helicobacter pylori (H. pylori) infects approximately half the world's population and is especially prevalent in the developing world. H. pylori is as an important cause of global ill health due to its known etiological role in peptic ulcer disease, dyspepsia, gastric cancer, lymphoma and, more recently recognised in iron deficiency anemia and idiopathic thrombocytopenic purpura. Increased antibiotic usage worldwide has led to antibiotic resistance among many bacteria, including H. pylori, resulting in falling success rates of first-line anti-H...
January 15, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29353044/bmp4-signaling-in-npcs-upregulates-bcl-xl-to-promote-their-survival-in-the-presence-of-fgf-2
#14
Hanako Yamamoto, Masashi Kurachi, Masae Naruse, Koji Shibasaki, Yasuki Ishizaki
We previously reported that BMP4 does not promote proliferation or differentiation of CD44-positive astrocyte precursor cells (APCs) but greatly promotes their survival in the presence of fibroblast growth factor-2 (FGF-2). In this study, we examined if BMP4 acts as a survival factor also for neural stem/progenitor cells (NPCs) isolated from ganglionic eminence of neonatal mouse brain. We found BMP4 promotes survival but not proliferation or differentiation of these cells, just as in the case for CD44-positive APCs...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29353042/ginkgolic-acid-induces-interplay-between-apoptosis-and-autophagy-regulated-by-ros-generation-in-colon-cancer
#15
Yuxia Liu, Bin Yang, Lirong Zhang, Xianling Cong, Zhen Liu, Yu Hu, Jing Zhang, Haixia Hu
Presently, developing effective anti-colon cancer drugs still remains to be important. Ginkgolic acids (GA), as a botanical drug extracted from the seed coat of Ginkgo biloba L., possess various bioactive properties. Our findings, for the first time, indicated that GA suppressed colon cancer cell proliferation, migration and invasion. GA led to cell death through G0/G1 phase arrest. In addition, apoptosis was significantly induced by GA treatment. The intrinsic apoptosis pathway was included, proved by the release of cytochrome c (Cyto-c) from the mitochondria into the cytosol...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29353040/eupatilin-an-activator-of-ppar%C3%AE-inhibits-the-development-of-oxazolone-induced-atopic-dermatitis-symptoms-in-balb-c-mice
#16
Yujung Jung, Jin-Chul Kim, No-June Park, Sim-Kyu Bong, Sullim Lee, Hyun Jegal, Li Tai Jin, Sang Moo Kim, Yong Kee Kim, Su-Nam Kim
Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29353026/efficacy-and-safety-of-lebrikizumab-an-anti-il-13-monoclonal-antibody-in-adults-with-moderate-to-severe-atopic-dermatitis-inadequately-controlled-by-topical-corticosteroids-a-randomized-placebo-controlled-phase-ii-trial-treble
#17
Eric L Simpson, Carsten Flohr, Lawrence F Eichenfield, Thomas Bieber, Howard Sofen, Alain Taïeb, Ryan Owen, Wendy Putnam, Marcela Castro, Kendra DeBusk, Chin-Yu Lin, Athina Voulgari, Karl Yen, Theodore A Omachi
BACKGROUND: Interleukin (IL)-13 plays a key role in type 2 inflammation and is an emerging pathogenic mediator in atopic dermatitis. OBJECTIVE: We investigated the efficacy and safety of lebrikizumab, an anti-IL-13 monoclonal antibody, as add-on to topical corticosteroid (TCS). METHODS: A randomized, placebo-controlled, double-blind, phase II study. Adults with moderate-to-severe AD were required to use twice-daily TCS, and randomized (1:1:1:1) to lebrikizumab 125 mg single dose (SD), 250 mg SD, 125 mg once every 4 weeks (Q4W), or placebo Q4W for 12 weeks, after 2-week TCS run-in...
January 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29353025/efficacy-and-safety-of-fezakinumab-an-anti-il-22-monoclonal-antibody-in-adults-with-moderate-to-severe-atopic-dermatitis-inadequately-controlled-by-conventional-treatments-a-randomized-double-blind-phase-2a-trial
#18
Emma Guttman-Yassky, Patrick M Brunner, Avidan U Neumann, Saakshi Khattri, Ana B Pavel, Kunal Malik, Giselle K Singer, Danielle Baum, Patricia Gilleaudeau, Mary Sullivan-Whalen, Sharon Rose, Shelbi Jim On, Xuan Li, Judilyn Fuentes-Duculan, Yeriel Estrada, Sandra Garcet, Claudia Traidl-Hoffmann, James G Krueger, Mark G Lebwohl
BACKGROUND: IL-22 promotes epidermal hyperplasia and inhibits skin barrier function. OBJECTIVE: Evaluate IL-22 blockade in adults with moderate-to-severe atopic dermatitis (AD). METHODS: Randomized, double-blind, placebo-controlled trial with intravenous fezakinumab monotherapy every 2wks for 10wks, with follow-up assessments until 20wks. SCORAD change from baseline at 12wks served as primary endpoint. RESULTS: At 12wks, mean SCORAD decline was 13·8±2·7 (fezakinumab) vs...
January 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29353019/induction-by-innate-defence-regulator-peptide-1018-of-pro-angiogenic-molecules-and-endothelial-cell-migration-in-a-high-glucose-environment
#19
Paulina Marin-Luevano, Valentin Trujillo, Adrian Rodriguez-Carlos, Irma González-Curiel, Jose A Enciso-Moreno, Robert E W Hancock, Bruno Rivas-Santiago
Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in endothelial cells. It also induced early angiogenin and prolonged anti-inflammatory TGFβ expression on endothelial cells, while suppressing early pro-inflammatory IL-1β expression levels...
January 15, 2018: Peptides
https://www.readbyqxmd.com/read/29353010/modulation-of-immune-responses-by-plasmodium-falciparum-infection-in-asymptomatic-children-living-in-the-endemic-region-of-mbita-western-kenya
#20
Caroline Kijogi, Daisuke Kimura, Lam Quoc Bao, Risa Nakamura, Evans Asena Chadeka, Ngetich Benard Cheruiyot, Felix Bahati, Kazuhide Yahata, Osamu Kaneko, Sammy M Njenga, Yoshio Ichinose, Shinjiro Hamano, Katsuyuki Yui
Individuals living in malaria endemic areas become clinically immune after multiple re-infections over time and remain infected without apparent symptoms. However, it is unclear why a long period is required to gain clinical immunity to malaria, and how such immunity is maintained. Although malaria infection is reported to induce inhibition of immune responses, studies on asymptomatic individuals living in endemic regions of malaria are relatively scarce. We conducted a cross-sectional study of immune responses in asymptomatic school children aged 4-16years living in an area where Plasmodium falciparum and Schistosoma mansoni infections are co-endemic in Kenya...
January 15, 2018: Parasitology International
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