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NanoMedicine

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https://www.readbyqxmd.com/read/28212584/hyaluronic-acid-serum-albumin-conjugate-based-nanoparticles-for-targeted-cancer-therapy
#1
Ravit Edelman, Yehuda G Assaraf, Inna Levitzky, Tal Shahar, Yoav D Livney
Multiple carcinomas including breast, ovarian, colon, lung and stomach cancer, overexpress the hyaluronic acid (HA) receptor, CD44. Overexpression of CD44 contributes to key cancer processes including tumor invasion, metastasis, recurrence, and chemoresistance. Herein, we devised novel targeted nanoparticles (NPs) for delivery of anticancer chemotherapeutics, comprised of self-assembling Maillard reaction-based conjugates of HA and bovine serum albumin (BSA). HA served as the hydrophilic block, and as the ligand for actively targeting cancer cells overexpressing CD44...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209060/the-use-of-spectroscopic-techniques-for-evaluating-the-coupling-of-porphyrins-on-biocompatible-nanoparticles-a-potential-system-for-photodynamics-theranostics-and-nano-drug-delivery-applications
#2
Lais N Magno, Fabio C Bezerra, Luiz E S Freire, Rubens A Guerra, Andris Figueiroa Bakuzis, Pablo Jose Goncalves
Modern medicine has been searching for new and more efficient strategies for diagnostics and therapeutics applications. Considering this, porphyrin molecules have received great interest for applications in photodiagnostics and phototherapies, even as magnetic nanoparticles for drug-delivery systems and magnetic-hyperthermia therapy. Aiming to obtain a multifunctional system, which combines diagnostics with therapeutic functions on the same platform, the present study employed UV/Vis absorption and fluorescence spectroscopies to evaluated the interaction between meso-tetrakis(p-sulfonatofenyl) porphyrin (TPPS) and maghemite nanoparticles (γ-Fe2O3)...
February 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28208215/nanoparticle-delivery-systems-general-approaches-and-their-implementation-in-multiple-myeloma
#3
REVIEW
Pilar de la Puente, Abdel Kareem Azab
Multiple myeloma (MM) is a hematological malignancy that remains incurable, with relapse rates greater than 90%. The main limiting factor for the effective use of chemotherapies in MM is the serious side effects caused by these drugs. The emphasis in cancer treatment has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted and rationally designed therapies showing greater efficacy and fewer side effects. Traditional chemotherapy has shown several disadvantages such as lack of targeting capabilities, systemic toxicity and side effects; low therapeutic index, as well as, most anticancer drugs have poor water solubility...
February 16, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28198204/nanomedicine-applied-to-cardiovascular-diseases-latest-developments
#4
Virna Margarita Martín Giménez, Diego E Kassuha, Walter Manucha
Cardiovascular diseases are a major cause of disability and they are currently responsible for a significant number of deaths in a large percentage of the world population. A large number of therapeutic options have been developed for the management of cardiovascular diseases. However, they are insufficient to stop or significantly reduce the progression of these diseases, and may produce unpleasant side effects. In this situation, the need arises to continue exploring new technologies and strategies in order to overcome the disadvantages and limitations of conventional therapeutic options...
February 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28198106/in-vitro-microfluidic-models-of-tumor-microenvironment-to-screen-transport-of-drugs-and-nanoparticles
#5
REVIEW
Altug Ozcelikkale, Hye-Ran Moon, Michael Linnes, Bumsoo Han
Advances in nanotechnology have enabled numerous types of nanoparticles (NPs) to improve drug delivery to tumors. While many NP systems have been proposed, their clinical translation has been less than anticipated primarily due to failure of current preclinical evaluation techniques to adequately model the complex interactions between the NP and physiological barriers of tumor microenvironment. This review focuses on microfluidic tumor models for characterization of delivery efficacy and toxicity of cancer nanomedicine...
February 14, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28198007/modulating-tumor-hypoxia-by-nanomedicine-for-effective-cancer-therapy
#6
REVIEW
Rana Jahanban-Esfahlan, Miguel de la Guardia, Delshad Ahmadi, Bahman Yousefi
Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis, metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside the tumors significantly hinder delivery of therapeutic agents. The low oxygen tension results in resistance to the current applied anti-cancer therapeutics including radiotherapy, chemotherapy and photodynamic therapy, the efficacy of which is firmly tied to the level of tumor oxygen supply. However, emerging data indicate that nanocarriers/nanodrugs can offer substantial benefits to improve the efficacy of current therapeutics, through modulation of tumor hypoxia...
February 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28193559/dual-functional-mesoporous-silicon-nanoparticles-enhance-the-radiosensitivity-of-vpa-in-glioblastoma
#7
Hailong Zhang, Wei Zhang, Yong Zhou, Yuhua Jiang, Shupeng Li
Radiotherapy is a critical strategy and standard adjuvant approach to glioblastoma treatment. One of the major challenges facing radiotherapy is to minimize radiation damage to normal tissue without compromising therapeutic effects on cancer cells. Various agents and numerous approaches have been developed to improve the therapeutic index of radiotherapy. Among them, radiosensitizers have attracted much attention because they selectively increase susceptibility of cancer cells to radiation and thus enhance biological effectiveness of radiotherapy...
February 10, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28192713/a-stable-nanoplatform-for-antitumor-activity-using-peg-pll-pla-triblock-co-polyelectrolyte
#8
Chaemin Lim, Taehoon Sim, Ngoc Ha Hoang, Kyung Taek Oh
Polyelectrolyte has been proposed as an efficient approach for various types of drug formulations. However, one drawback of using the conventional polyelectrolyte for drug delivery is its dissociation in in vivo conditions by counter ions due to the lack of self-assembling aggregation force. In this study, we reported a stable nanoplatform based on triblock co-polyelectrolyte composed of a poly(ethylene glycol), poly(l-lysine), and poly(lactic acid). These co-polyelectrolytes formed stable aggregates through the hydrophobic interaction of PLA and showed consistent particle sizes under a high salt concentration...
February 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28192672/smart-nanostructures-for-cargo-delivery-uncaging-and-activating-by-light
#9
Mahdi Karimi, Parham Sahandi Zangabad, Soodeh Baghaee-Ravari, Mahdi Ghazizadeh, Hamed Mirshekari, Michael R Hamblin
Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, etc. Among drug delivery systems (DDSs), smart nanocarriers that can respond to specific stimuli in their local environment represent a growing field. Nanoplatforms that can be activated by an external application of light, can be used for a wide variety of photo-activated therapies, (especially light-triggered DDSs) relying on photo-isomerization, photo-crosslinking/uncrosslinking, photo-reduction, etc...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28192249/a-glucose-targeted-mixed-micellar-formulation-outperforms-genexol-in-breast-cancer-cells
#10
Marcela A Moretton, Ezequiel Bernabeu, Estefanía Grotz, Lorena Gonzalez, Marcela Zubillaga, Diego A Chiappetta
Breast cancer represents the top cancer among women, accounting 521.000 deaths per year. Development of targeted nanomedicines to breast cancer tissues represents a milestone to reduce chemotherapy side effects. Taking advantage of the over-expression of glucose (Glu) membrane transporters in breast cancer cells, we aim to expand the potential of a paclitaxel (PTX)-loaded mixed micellar formulation based on polyvinyl caprolactam-polyvinylacetate-polyethylene glycol graft copolymer (Soluplus®) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) by its surface decoration with Glu moieties...
February 10, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28191948/supramolecular-trojan-horse-for-nuclear-delivery-of-dual-anticancer-drugs
#11
Yanbin Cai, Haosheng Shen, Jie Zhan, Mingliang Lin, Liuhan Dai, Chunhua Ren, Yang Shi, Jianfeng Liu, Jie Gao, Zhimou Yang
Nuclear delivery and accumulation is very important for many anticancer drugs which interact with DNA or its associated enzymes in nucleus. However, it is very difficult for neutrally and negatively charged anticancer drugs such as 10-hydroxycamptothecine (HCPT). Here we report a simple strategy to construct supramolecular nanomedicines for nuclear delivery of dual synergistic anticancer drugs. Our strategy utilizes the co-assembly of a negatively charged HCPT-peptide amphiphile and the positively charged cisplatin...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28191500/insights-from-genetic-model-systems-of-retinal-degeneration-role-of-epsins-in-retinal-angiogenesis-and-vegfr2-signaling
#12
Yunzhou Dong, Xue Cai, Yong Wu, Yanjun Liu, Lin Deng, Hong Chen
The retina is a light sensitive tissue that contains specialized photoreceptor cells called rods and cones which process visual signals. These signals are relayed to the brain through interneurons and the fibers of the optic nerve. The retina is susceptible to a variety of degenerative diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa (RP) and other inherited retinal degenerations. In order to reveal the mechanism underlying these diseases and to find methods for the prevention/treatment of retinal degeneration, animal models have been generated to mimic human eye diseases...
January 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28187380/biomimetic-nanoassemblies-of-1-o-octodecyl-2-conjugated-linoleoyl-sn-glycero-3-phosphatidyl-gemcitabine-with-phospholipase-a2-triggered-degradation-for-the-treatment-of-cancer
#13
Jing Zuo, Li Tong, Lina Du, Ming Yang, Yiguang Jin
Phospholipids are important biomolecules with strong self-assembling ability to form biomembranes or liposomes. However, biomimetic prodrugs of phospholipids are not well known, including their self-assembling behavior at the air/water interface or in aqueous media. Here we design and prepare a biomimetic phospholipid-like amphiphilic prodrug, 1-O-octodecyl-2-conjugated linoleoyl-sn-glycero-3-phosphatidyl gemcitabine (OLGPG). After spreading at the air/water interface, it formed Langmuir monolayers. Stable nanoassemblies were obtained based on molecular self-assembly after OLGPG was injected in water...
February 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187243/arginine-modified-nanostructured-lipid-carriers-with-charge-reversal-and-ph-sensitive-membranolytic-properties-for-anticancer-drug-delivery
#14
Minjie Sun, Jing Li, Cuiting Zhang, Ying Xie, Hongzhi Qiao, Zhigui Su, David Oupický, Qineng Ping
The ability to escape endo/lysosomal trafficking is critically important to prevent entrapment of nanomedicines in lysosomes and to achieve maximum therapeutic efficacy of drugs delivered to cells through endocytosis. In this study, a novel pH-sensitive chitosan carrier with the ability to reverse its charge during endo/lysosomal trafficking is developed as a way of improving lysosomal disruption. N-Arginine-N-octyl chitosan (AOCS) is synthesized by grafting l-arginine onto carboxymethyl chitosan. The AOCS is used to modify the surface of nanostructured lipid carriers (NLC) to prepare pH-sensitive charge-reversal lysosomolytic nanocarriers (ANLC)...
February 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28186523/amphiphilic-dna-tiles-for-controlled-insertion-and-2d-assembly-on-fluid-lipid-membranes-the-effect-on-mechanical-properties
#15
Chikara Dohno, Shingo Makishi, Kazuhiko Nakatani, Sonia Contera
Future lipid membrane-associated DNA nanostructures are expected to find applications ranging from synthetic biology to nanomedicine. Here we have designed and synthesized DNA tiles and modified them with amphiphilic covalent moieties. dod-DEG groups, which consist of a hydrophilic diethylene glycol (DEG) and a hydrophobic dodecyl group, are introduced at the phosphate backbone to create amphiphilic DNA strands which are subsequently introduced into one face of the DNA tiles. In this way the tile becomes able to stably bind to lipid membranes by insertion of the hydrophobic groups inside the bilayer core...
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28186439/computational-nanomedicine-for-mechanistic-elucidation-of-bilayer-nanoparticle-mediated-release-for-tissue-engineering
#16
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Temporal control of growth-factor release from nanoparticles is essential to many tissue engineering applications, yet remains a challenge due to its complicated behavior. The interplay between nanoparticle characteristics and release mechanisms can be captured using computational models. This study aims to develop two novel models to represent the release of bilayer nanoparticles. MATERIALS & METHODS: Bilayer nanoparticles were prepared and characterized experimentally...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28183591/graphene-oxide-chitosan-nanocomposites-for-intracellular-delivery-of-immunostimulatory-cpg-oligodeoxynucleotides
#17
Huijie Zhang, Ting Yan, Sha Xu, Shini Feng, Dandi Huang, Morihisa Fujita, Xiao-Dong Gao
CpG oligodeoxynucleotides (ODNs) activate innate and adaptive immune responses, and show strong potential as immunotherapeutic agents against various diseases. Benefiting from their unique physicochemical properties, graphene oxide (GO) has recently attracted great attention in nanomedicine. In this study, we developed a novel CpG ODNs delivery system based on GO-chitosan (GO-CS) nanocomposites. GO-CS nanocomposites were prepared by self-assembly of both components via electrostatic interactions. Compared with GO, GO-CS nanocomposites possessed smaller size, positive surface charge and lower cytotoxicity...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28182187/multiscale-modeling-of-plasmonic-enhanced-energy-transfer-and-cavitation-around-laser-excited-nanoparticles
#18
Adrien Dagallier, Etienne Boulais, Christos Boutopoulos, Rémi Lachaine, Michel Meunier
Nanoscale bubbles generated around laser-excited metallic nanoparticles are promising candidates for targeted drug and gene delivery in living cells. The development of new nanomaterials for efficient nanobubble-based therapy is however limited by the lack of reliable computational approaches for the prediction of their size and dynamics, due to the wide range of time and space scales involved. In this work, we present a multiscale modeling framework that segregates the various channels of plasmon de-excitation and energy transfer to describe the generation and dynamics of plasmonic nanobubbles...
February 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28181831/basic-concepts-and-recent-advances-in-nanogels-as-carriers-for-medical-applications
#19
Iordana Neamtu, Alina Gabriela Rusu, Alina Diaconu, Loredana Elena Nita, Aurica P Chiriac
Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called as next generation drug delivery systems due to their relatively high drug encapsulation capacity, uniformity, tunable size, ease of preparation, minimal toxicity, stability in the presence of serum, and stimuli responsiveness. Nanogels show a great potential in chemotherapy, diagnosis, organ targeting and delivery of bioactive substances...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181459/cerium-oxide-nanoparticles-a-radical-approach-to-neurodegenerative-disease-treatment
#20
Shuguftha Naz, James Beach, Blaze Heckert, Tanuja Tummala, Oleksandra Pashchenko, Tuhina Banerjee, Santimukul Santra
Despite advances in understanding the factors that cause many neurodegenerative diseases (NDs), no current therapies have yielded significant results. Cerium oxide nanoparticles (CeONPs) have recently emerged as therapeutics for the treatment of NDs due to their antioxidant properties. This report summarizes the recent findings regarding CeONPs in treatment of various NDs, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis. Interest in CeONPs as a potential nanomedicine for NDs has increased due to: their ability to alter signaling pathways, small diameter allowing passage through the blood-brain barrier and scavenging of reactive oxygen species...
February 9, 2017: Nanomedicine
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