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https://www.readbyqxmd.com/read/29139338/freeze-drying-of-silica-nanoparticles-redispersibility-toward-nanomedicine-applications
#1
Agustin S Picco, Larissa F Ferreira, Michelle S Liberato, Gabriela B Mondo, Mateus B Cardoso
AIM: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. METHODS: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants...
November 15, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29138565/erratum-bypassing-the-epr-effect-with-a-nanomedicine-harboring-a-sustained-release-function-allows-better-tumor-control-corrigendum
#2
(no author information available yet)
[This corrects the article on p. 2485 in vol. 10, PMID: 25848266.].
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29133898/intertwining-dna-rna-nanocapsules-loaded-with-tumor-neoantigens-as-synergistic-nanovaccines-for-cancer-immunotherapy
#3
Guizhi Zhu, Lei Mei, Harshad D Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen
Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-specific peptide neoantigens into antigen presenting cells (APCs) in lymph nodes for cancer immunotherapy. These nanovaccines were prepared by (1) producing tandem CpG and shRNA via concurrent rolling circle replication and rolling circle transcription, (2) self-assembling CpG and shRNA into DNA-RNA microflowers, (3) shrinking microflowers into iDR-NCs using PEG-grafted cationic polypeptides, and (4) physically loading neoantigen into iDR-NCs...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133762/rare-earth-nanoparticle-induced-cytotoxicity-on-spatial-cognition-memory-of-mouse-brain
#4
Cai-Hou Lin, Gui-Fen Liu, Jing Chen, Yan Chen, Ru-Hui Lin, Hong-Xing He, Jian-Ping Chen
BACKGROUND: Luminescent rare-earth-based nanoparticles have been increasingly used in nanomedicine due to their excellent physicochemical properties, such as biomedical imaging agents, drug carriers, and biomarkers. However, biological safety of the rare-earth-based nanomedicine is of great significance for future development in practical applications. In particular, biological effects of rare-earth nanoparticles on human's central nervous system are still unclear. This study aimed to investigate the potential toxicity of rare-earth nanoparticles in nervous system function in the case of continuous exposure...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29133206/relationship-between-polarities-of-antibiotic-and-polymer-matrix-on-nanoparticle-formulations-based-on-aliphatic-polyesters
#5
J A S Ritsema, E M A Herschberg, S E Borgos, C Løvmo, R Schmid, Y M Te Welscher, G Storm, C F van Nostrum
In the field of nanomedicine, nanoparticles are developed to target antibiotics to sites of bacterial infection thus enabling adequate drug exposure and decrease development of resistant bacteria. In the present study, we investigated the encapsulation of two antibiotics with different polarity into different PEGylated polymeric nanoparticles based on aliphatic polyesters, to obtain a better understanding of critical factors determining encapsulation and release. The nanoparticles were prepared from diblock copolymers comprising of a poly(ethylene glycol) block attached to an aliphatic polyester block of varying polarity: poly(lactic-co-glycolic acid) (mPEG-PLGA), poly(lactic-co-hydroxymethyl glycolic acid) (mPEG-PLHMGA) and poly(lactic-co-benzyloxymethyl glycolic acid) (mPEG-PLBMGA)...
November 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29132541/novel-treatment-strategies-using-tio2-nanowired-delivery-of-histaminergic-drugs-and-antibodies-to-tau-with-cerebrolysin-for-superior-neuroprotection-in-the-pathophysiology-of-alzheimer-s-disease
#6
Aruna Sharma, Preeti K Menon, Ranjana Patnaik, Dafin F Muresanu, José V Lafuente, Z Ryan Tian, Asya Ozkizilcik, Rudy J Castellani, Herbert Mössler, Hari S Sharma
More than 5.5 million Americans of all ages are suffering from Alzheimer's disease (AD) till today for which no suitable therapy has been developed so far. Thus, there is an urgent need to explore novel therapeutic measures to contain brain pathology in AD. The hallmark of AD includes amyloid-beta peptide (AβP) deposition and phosphorylation of tau in AD brain. Recent evidences also suggest a marked decrease in neurotrophic factors in AD. Thus, exogenous supplement of neurotrophic factors could be one of the possible ways for AD therapy...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29130038/nanomedicine-for-inner-ear-diseases-a-review-of-recent-in-vivo-studies
#7
REVIEW
Dong-Kee Kim
Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review in vivo animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid) (PLGA). The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29128847/versatile-hyaluronic-acid-modified-aq4n-cu-ii-gossypol-infinite-coordination-polymer-nanoparticles-multiple-tumor-targeting-highly-efficient-synergistic-chemotherapy-and-real-time-self-monitoring
#8
Shihong Shen, Youshen Wu, Ke Li, Ya Wang, Jimin Wu, Yun Zeng, Daocheng Wu
A novel strategy for the preparation of infinite coordination polymer nanoparticles (ICPs) based nanomedicines was developed, with which hyaluronic acid modified AQ4N-Cu(II)-gossypol nanoparticles (HA@AQ4N-Cu(II)-gossypol NPs) were obtained. This is a highly efficient nanomedicine, in which gossypol serves as a chemotherapeutic agent and a self-carrier material; Cu(II) serves as the connecting point and anti-tumor enhancer; AQ4N not only serves as a chemotherapeutic agent and self-carrier material, but also as the self-monitor based on its inherent fluorescence...
November 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/29127069/lectin-conjugated-ph-responsive-mesoporous-silica-nanoparticles-for-targeted-bone-cancer-treatment
#9
Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consists of: i) a polyacrylic acid (PAA) capping layer grafted to MSNs via an acid-cleavable acetal linker, to minimize premature cargo release and provide the nanosystem of pH-responsive drug delivery ability; and ii) a targeting ligand, the plant lectin concanavalin A (ConA), able to selectively recognize, bind and internalize owing to certain cell-surface glycans, such as sialic acids (SA), overexpressed in given tumor cells...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29125066/autonomous-self-navigating-drug-delivery-vehicles-from-science-fiction-to-reality
#10
Valery A Petrenko
Low efficacy of targeted nanomedicines in biological experiments enforced us to challenge the traditional concept of drug targeting and suggest a paradigm of 'addressed self-navigating drug-delivery vehicles,' in which affinity selection of targeting peptides and vasculature-directed in vivo phage screening is replaced by the migration selection, which explores ability of 'promiscuous' phages and their proteins to migrate through the tumor-surrounding cellular barriers, using a 'hub and spoke' delivery strategy, and penetrate into the tumor affecting the diverse tumor cell population...
December 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/29125062/drug-delivery-during-pregnancy-how-can-nanomedicine-be-used
#11
Medha D Joshi
No abstract text is available yet for this article.
December 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/29124842/porous-polyelectrolytes-charge-pores-for-more-functionalities
#12
Weiyi Zhang, Qiang Zhao, Jiayin Yuan
The past decade has witnessed rapid advances in porous polyelectrolytes and there is tremendous ongoing interest in their synthesis and applications in environment, energy, biomedicine and catalysis. The porous polyelectrolytes research is motivated by the synergy of, apart from the flexible choice of functional organic groups and processing technologies, the charge and pores spanning length scales from individual polyelectrolyte backbones to their nano/micro superstructures. This review surveys recent progresses on porous polyelectrolytes including membranes, particles, scaffolds, high surface area powders/resins, and their derivatives...
November 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29123399/multifunctional-gold-nanorods-and-docetaxel-encapsulated-liposomes-for-combined-thermo-and-chemotherapy
#13
Haiying Hua, Nan Zhang, Dan Liu, Lili Song, Tuanbing Liu, Shasha Li, Yongxing Zhao
Personalized and precise nanomedicines are highly demanded for today's medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29123332/target-or-clear-zirconium-89-labeled-silica-nanoparticles-for-enhanced-cancer-directed-uptake-in-melanoma-a-comparison-of-radiolabeling-strategies
#14
Feng Chen, Kai Ma, Li Zhang, Brian Madajewski, Pat Zanzonico, Sonia Sequeira, Mithat Gonen, Ulrich Wiesner, Michelle S Bradbury
Designing a nanomaterials platform with high target-to-background ratios has long been one of the major challenges in the field of nanomedicine. Here, we introduce a "target-or-clear" multifunctional nanoparticle platform that demonstrates high tumor-targeting efficiency and retention while minimizing off-target effects. Encouraged by the favorable preclinical and clinical pharmacokinetic profiles derived after fine-tuning surface chemical properties of radioiodinated ((124)I, t1/2 = 100.2 h) ultrasmall cRGDY-conjugated fluorescent silica nanoparticles (C dots), we sought to investigate how the biological properties of these radioconjugates could be influenced by the conjugation of radiometals such as zirconium-89 ((89)Zr, t1/2 = 78...
October 10, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/29116739/gold-nanocluster-mediated-cellular-death-under-electromagnetic-radiation
#15
Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Penya Auladell, Laura Fabregas, Nicholas L Fletcher, Zachary H Houston, Kristofer James Thurecht, Nicolas H Voelcker
Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy due to their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to 1 GHz electromagnetic field (microwave radiation, µW), cell viability significantly decreases thus demonstrating that Au NCs exhibit specific µW dependent cytotoxicity, likely resulting from localized heating...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29114273/formulation-and-characterization-of-nanomedicine-solid-lipid-nanoparticle-associate-with-the-extract-of-pterospermum-acerifolium-for-the-screening-of-neurochemicals-and-neuroendocrine-effects
#16
Ankur Choubey, Ritu Gilhotra, Santosh Kumar Singh, Gopal Garg
Background: Nanotechnology has given the likelihood of conveying medications to particular cells utilizing nanoparticles. Nanosystems can convey the dynamic constituent at an adequate fixation amid the whole treatment time frame, guiding it to the fancied site of activity. Traditional medications do not meet these necessities. The fundamental motivation behind creating elective medication conveyance advancements is to expand effectiveness of medication conveyance and security during the time spent medication conveyance and give more accommodation to the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29109786/-one-pot-fabrication-of-highly-versatile-and-biocompatible-poly-vinyl-alcohol-porphyrin-based-nanotheranostics
#17
Yan Luo, Hao Wu, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-Yin Lin, Hongyong Zhang, Jeffrey H Walton, Yousif Ajena, Yide Hu, Kit S Lam, Yuanpei Li
Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within a single platform. However, the clinical translation of these agents is severely limited by the complexity of fabrication, long-term toxicity of the materials, and unfavorable biodistributions. Here we report an extremely simple and robust approach to develop highly versatile and biocompatible theranostic poly(vinyl alcohol)-porphyrin nanoparticles (PPNs)...
2017: Theranostics
https://www.readbyqxmd.com/read/29109774/dual-functioned-pegylated-phospholipid-micelles-containing-cationic-antimicrobial-decapeptide-for-treating-sepsis
#18
Wonhwa Lee, Eun Ji Park, Gahee Min, Joonhyeok Choi, Dong Hee Na, Jong-Sup Bae
Despite intensive investigation of molecular mechanisms underlying the pathogenesis of sepsis, many aspects of sepsis remain unresolved; this hampers the development of appropriate therapeutics. In the present study, we developed a biologic nanomedicine containing a cationic antimicrobial decapeptide KSLW (KKVVFWVKFK), self-associated with biocompatible and biodegradable PEGylated phospholipid micelles (PLM), and analyzed its efficacy for treating sepsis. KSLW was modified with polyethylene glycol (PEG)-aldehyde or was conjugated with distearoylphosphatidylethanolamine (DSPE) -PEG-aldehyde...
2017: Theranostics
https://www.readbyqxmd.com/read/29109768/strategies-for-preparing-albumin-based-nanoparticles-for-multifunctional-bioimaging-and-drug-delivery
#19
REVIEW
Fei-Fei An, Xiao-Hong Zhang
Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine...
2017: Theranostics
https://www.readbyqxmd.com/read/29109766/cancer-nanomedicines-stabilized-by-%C3%AF-%C3%AF-stacking-between-heterodimeric-prodrugs-enable-exceptionally-high-drug-loading-capacity-and-safer-delivery-of-drug-combinations
#20
Hangxiang Wang, Jianmei Chen, Chang Xu, Linlin Shi, Munire Tayier, Jiahui Zhou, Jun Zhang, Jiaping Wu, Zhijian Ye, Tao Fang, Weidong Han
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that synergistic delivery of two chemotherapeutic drugs in a single nanoparticle reservoir could be achieved through the rational chemical ligation of the drugs followed by supramolecular nano-assembly via blending of the drugs with a minimal amount of matrix...
2017: Theranostics
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