keyword
https://read.qxmd.com/read/38493374/i-ll-never-give-up-a-qualitative-study-of-caregivers-perceptions-and-decisional-processes-when-feeding-infants-and-toddlers-novel-and-disliked-foods
#1
JOURNAL ARTICLE
Susan L Johnson, Kameron J Moding, Abigail Flesher, Rebecca Boenig, Joseph Campain
OBJECTIVE: To better understand caregivers' decisional processes related to offering novel and disliked foods to their infants and toddlers. DESIGN: As part of a parent study on young children's food acceptance that took place in Denver, CO, this secondary analysis used a basic qualitative approach to explore caregivers' decisional processes related to repeated exposure and children's food rejection. PARTICIPANTS: English-speaking caregivers of infants and toddlers (aged 6-24 months; n = 106) were recruited via flyers and social media and interviewed (from July, 2017 to January, 2018) during a laboratory visit focused on introducing a novel food...
March 15, 2024: Journal of Nutrition Education and Behavior
https://read.qxmd.com/read/38493254/modeling-and-analysis-of-the-effect-of-optimal-virus-control-on-the-spread-of-hfmd
#2
JOURNAL ARTICLE
Hui Wang, Weihua Li, Lei Shi, Gaofang Chen, Zhengwen Tu
A within-host and between-host hand, foot and mouth disease (HFMD) mathematical model is established and the affect of optimal control in its within-host part on HFMD transmission is studied. Through define two basic reproduction numbers, by using the fast-slow system analysis method of time scale, the global stabilities of the between-host (slow) system and within-host (fast) system are researched, respectively. An optimal control problem with drug-treatment control on coupled within-host and between-host HFMD model is formulated and analysed theoretically...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493237/lifestyle-and-demographic-associations-with-47-inflammatory-and-vascular-stress-biomarkers-in-9876-blood-donors
#3
JOURNAL ARTICLE
Bertram Kjerulff, Joseph Dowsett, Rikke Louise Jacobsen, Josephine Gladov, Margit Hørup Larsen, Agnete Troen Lundgaard, Karina Banasik, David Westergaard, Susan Mikkelsen, Khoa Manh Dinh, Lotte Hindhede, Kathrine Agergård Kaspersen, Michael Schwinn, Anders Juul, Betina Poulsen, Birgitte Lindegaard, Carsten Bøcker Pedersen, Clive Eric Sabel, Henning Bundgaard, Henriette Svarre Nielsen, Janne Amstrup Møller, Jens Kjærgaard Boldsen, Kristoffer Sølvsten Burgdorf, Lars Vedel Kessing, Linda Jenny Handgaard, Lise Wegner Thørner, Maria Didriksen, Mette Nyegaard, Niels Grarup, Niels Ødum, Pär I Johansson, Poul Jennum, Ruth Frikke-Schmidt, Sanne Schou Berger, Søren Brunak, Søren Jacobsen, Thomas Folkmann Hansen, Tine Kirkeskov Lundquist, Torben Hansen, Torben Lykke Sørensen, Torben Sigsgaard, Kaspar René Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Henrik Ullum, Klaus Rostgaard, Erik Sørensen, Ole Birger Pedersen, Sisse Rye Ostrowski, Christian Erikstrup
BACKGROUND: The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. METHODS: A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants...
March 16, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38493116/variation-in-shoot-architecture-traits-and-their-relationship-to-canopy-coverage-and-light-interception-in-soybean-glycine-max
#4
JOURNAL ARTICLE
Suma Sreekanta, Allison Haaning, Austin Dobbels, Riley O'Neill, Anna Hofstad, Kamaldeep Virdi, Fumiaki Katagiri, Robert M Stupar, Gary J Muehlbauer, Aaron J Lorenz
BACKGROUND: In soybeans, faster canopy coverage (CC) is a highly desirable trait but a fully covered canopy is unfavorable to light interception at lower levels in the canopy with most of the incident radiation intercepted at the top of the canopy. Shoot architecture that influences CC is well studied in crops such as maize and wheat, and altering architectural traits has resulted in enhanced yield. However, in soybeans the study of shoot architecture has not been as extensive. RESULTS: This study revealed significant differences in CC among the selected soybean accessions...
March 16, 2024: BMC Plant Biology
https://read.qxmd.com/read/38493050/mini-bones-miniaturized-bone-in-vitro-models
#5
REVIEW
Maria Gabriella Fois, Martijn van Griensven, Stefan Giselbrecht, Pamela Habibović, Roman K Truckenmüller, Zeinab Niloofar Tahmasebi Birgani
In bone tissue engineering (TE) and regeneration, miniaturized, (sub)millimeter-sized bone models have become a popular trend since they bring about physiological biomimicry, precise orchestration of concurrent stimuli, and compatibility with high-throughput setups and high-content imaging. They also allow efficient use of cells, reagents, materials, and energy. In this review, we describe the state of the art of miniaturized in vitro bone models, or 'mini-bones', describing these models based on their characteristics of (multi)cellularity and engineered extracellular matrix (ECM), and elaborating on miniaturization approaches and fabrication techniques...
March 15, 2024: Trends in Biotechnology
https://read.qxmd.com/read/38492953/exploring-the-free-energy-landscape-of-proteins-using-magnetic-tweezers
#6
JOURNAL ARTICLE
Hao Sun, Shimin Le, Zilong Guo, Hu Chen
Proteins fold to their native states by searching through the free energy landscapes. As single-domain proteins are the basic building block of multiple-domain proteins or protein complexes composed of subunits, the free energy landscapes of single-domain proteins are of critical importance to understand the folding and unfolding processes of proteins. To explore the free energy landscapes of proteins over large conformational space, the stability of native structure is perturbed by biochemical or mechanical means, and the conformational transition process is measured...
2024: Methods in Enzymology
https://read.qxmd.com/read/38492627/the-epoch-making-importance-of-ervin-bauer-s-theoretical-biology
#7
JOURNAL ARTICLE
Attila Grandpierre
Ervin Bauer was the only biologist who recognized that the best way to develop theoretical biology on an equal footing with theoretical physics was to follow the method that has ensured the great successes of modern theoretical physics: the general method of science. Following this method, he succeeded to find the universal principle of biology. From this principle he managed to derive all the basic equations of biology, that of metabolism, reproduction, growth, responsiveness and successfully explained all the fundamental phenomena of life...
March 14, 2024: Bio Systems
https://read.qxmd.com/read/38492555/finger-counting-finger-number-gesturing-and-basic-numerical-skills-a-cross-sectional-study-in-3-to-5-year-olds
#8
JOURNAL ARTICLE
Stephanie Roesch, Korbinian Moeller, Julia Bahnmueller
Recent evidence suggests that using finger-based strategies is beneficial for the acquisition of basic numerical skills. There are basically two finger-based strategies to be distinguished: (a) finger counting (i.e., extending single fingers successively) and (b) finger number gesturing (i.e., extending fingers simultaneously to represent magnitudes). In this study, we investigated both spontaneous and prompted finger counting and finger number gesturing as well as their contribution to basic numerical skills in 3- to 5-year-olds (N = 156)...
March 15, 2024: Journal of Experimental Child Psychology
https://read.qxmd.com/read/38492534/comprehensive-analysis-of-transcription-factor-based-molecular-subtypes-and-their-correlation-to-clinical-outcomes-in-small-cell-lung-cancer
#9
JOURNAL ARTICLE
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
BACKGROUND: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate the underlying characteristics associated with differences in clinical outcomes between subtypes. METHODS: IHC (n = 252), target exome sequencing (n = 422), and whole transcriptome sequencing (WTS, n = 189) data generated from 427 patients (86...
March 15, 2024: EBioMedicine
https://read.qxmd.com/read/38492440/updating-functional-brain-units-insights-far-beyond-luria
#10
REVIEW
Jordi Peña-Casanova, Gonzalo Sánchez-Benavides, Jorge Sigg-Alonso
This paper reviews Luria's model of the three functional units of the brain. To meet this objective, several issues were reviewed: the theory of functional systems and the contributions of phylogenesis and embryogenesis to the brain's functional organization. This review revealed several facts. In the first place, the relationship/integration of basic homeostatic needs with complex forms of behavior. Secondly, the multi-scale hierarchical and distributed organization of the brain and interactions between cells and systems...
February 29, 2024: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/38492432/radical-hospitality-innovative-programming-to-build-community-and-meet-the-needs-of-people-who-use-drugs-at-a-government-sanctioned-overdose-prevention-site-in-san-francisco-california
#11
JOURNAL ARTICLE
Lynn D Wenger, Terry Morris, Kelly R Knight, Cariné E Megerian, Peter J Davidson, Leslie W Suen, Veronica Majano, Barrot H Lambdin, Alex H Kral
BACKGROUND: The Tenderloin Center (TLC), a multi-service center where people could receive or be connected to basic needs, behavioral health care, housing, and medical services, was open in San Francisco for 46 weeks in 2022. Within a week of operation, services expanded to include an overdose prevention site (OPS), also known as safe consumption site. OPSs have operated internationally for over three decades, but government-sanctioned OPSs have only recently been implemented in the United States...
March 15, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38492395/the-hapten-rigidity-improves-antibody-performances-in-immunoassay-for-rifamycins-immunovalidation-and-molecular-mechanism
#12
JOURNAL ARTICLE
Yingjie Zhang, Weilin Wu, Qing Li, Penghui Zhou, Kai Wen, Jianzhong Shen, Zhanhui Wang
The immunogenicity of haptens determines the performance of the resultant antibody for small molecules. Rigidity is one of the basic physicochemical properties of haptens. However, few studies have investigated the effect of hapten rigidity on the strength of an immune response and overall antibody performance. Herein, we introduce three molecular descriptors that quantify hapten rigidity. By using of these descriptors, four rifamycin haptens with varied rigidity were designed. The structural and physicochemical feasibility of the designed haptens was then assessed by computational chemistry...
March 12, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38492262/alterations-in-performance-and-discriminating-power-of-the-death-suicide-implicit-association-test-across-the-lifespan
#13
JOURNAL ARTICLE
Donna A Ruch, Jeffrey A Bridge, Jaclyn Tissue, Sean P Madden, Hanga Galfavy, Marianne Gorlyn, Arielle H Sheftall, Katalin Szanto, John G Keilp
The Death/Suicide Implicit Association Test (d/s-IAT) has differentiated individuals with prior and prospective suicide attempts in previous studies, however, age effects on test results remains to be explored. A three-site study compared performance on the d/s-IAT among participants aged 16-80 years with depression and prior suicide attempt (n = 82), with depression and no attempts (n = 80), and healthy controls (n = 86). Outcome measures included the standard difference (D) score, median reaction times, and error rates...
March 4, 2024: Psychiatry Research
https://read.qxmd.com/read/38492187/molecular-structural-and-functional-diversity-of-universal-stress-proteins-usps-in-bacteria-plants-and-their-biotechnological-applications
#14
REVIEW
Bilkees Nabi, Manoj Kumawat, Neeraj Ahlawat, Sushma Ahlawat
Universal stress proteins (USPs) are widely distributed and play crucial roles in cellular responses to biotic and abiotic stresses. These roles include regulating cell growth and development, cell motility, hypoxia responses, and ion sequestration. With the increasing frequency and intensity of extreme weather events due to climate change, pathogens have developed different strategies to withstand environmental stresses, in which USPs play a significant role in their survival and virulence. In this study, we analyzed the importance of USPs in various organisms, such as archaea, plants, and fungi, as a parameter that influences their survival...
March 16, 2024: Protein Journal
https://read.qxmd.com/read/38492121/lived-experience-of-health-and-wellbeing-among-young-people-with-early-psychosis-in-aotearoa-new-zealand
#15
JOURNAL ARTICLE
Victoria Chinn, Ella Creagh, Tracey Gardiner, Briony Drysdale, Pāyal Ramritu, Zara Mansoor, Susanna Every-Palmer, Matthew Jenkins
First episode psychosis (FEP) can disrupt a young person's life and future health. Those with lived experience of FEP can inform effective support. This study investigated how young people with FEP experience good health and wellbeing living in Aotearoa New Zealand. Recent clients of early intervention services (n = 12) shared their stories across varying traditional and creative platforms. Thematic analysis revealed seven themes important for living well with FEP: whanaungatanga (relationships), addressing stigma, finding out who I am with psychosis, getting the basics right, collaborative healthcare, understanding psychosis, and access to resources...
March 16, 2024: Community Mental Health Journal
https://read.qxmd.com/read/38492028/what-is-the-place-of-ultrasound-in-msk-imaging
#16
EDITORIAL
Ronald S Adler
During the past four decades, ultrasound has become popular as an imaging modality applied to the musculoskeletal (MSK) system, particularly outside the USA, due to its low cost, accessibility, and lack of ionizing radiation. A basic requirement in performing these examinations is to have a core group of radiologists and ultrasound technologists with expertise in MSK ultrasound. The extent to which ultrasound will be part of the imaging offered by a particular radiology practice or in an academic institution will vary according to expertise, availability, and reimbursements...
March 16, 2024: Skeletal Radiology
https://read.qxmd.com/read/38491932/factors-predisposing-emergency-medical-technicians-to-workplace-violence-a-cross-sectional-study
#17
JOURNAL ARTICLE
Tshikani Lewis Khoza, Maureen Nokuthula Sibiya, Nombeko Mshunqane
Emergency medical technicians (EMT) are at high risk of workplace violence as they often care for patients in uncontrolled and often hostile emergency settings. Gauteng Province, the most populous province in South Africa, caters for 75% of the total population which is dependant on state funded health care. Public sector EMTs' have been robbed with aggravated circumstances, assaulted with intent to do grievous bodily harm, raped and even murdered whilst on duty. Despite this, comprehensive studies investigating the factors that predispose public sector EMTs' to workplace violence in Gauteng Province are lacking...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://read.qxmd.com/read/38491895/situation-analysis-of-the-quality-of-primary-health-care-services-in-pakistan
#18
JOURNAL ARTICLE
Muhammad Navid Tahir, Nauman Ali Ch, Muhammad Waqas Farooq, Ghazanfar Mubin, Jafar Riaz Kataria
BACKGROUND: Primary health care services to promote the mental and physical health of communities include preventive, promotive, curative, general hygiene, and nutritional elements. AIM: To assess the quality of service delivery at primary healthcare settings in Punjab, Pakistan. METHODS: Quantitative surveys were conducted at 106 health facilities: 92 basic health units (BHUs) and 14 rural health centres (RHCs) across Punjab in 2020. Data from the survey were supplemented with information from observations by the researchers and all data were analysed using SPSS version 25...
February 25, 2024: Eastern Mediterranean Health Journal
https://read.qxmd.com/read/38491816/advancing-access-to-care-an-assessment-of-the-prehospital-system-in-senegal
#19
JOURNAL ARTICLE
Kamil Michalski, Moustapha Diedhiou, Matin Kerachian, Jeremy Grushka, Jacques Noel Tendeng, Mohamed Lamine Diao, Mamadou D Beye, Johana Montero Ortiz, Tarek Razek, Dan L Deckelbaum, Ibrahim Konate
BACKGROUND: Most low- and middle-income countries do not have a mature prehospital system limiting access to definitive care. This study sought to describe the current state of the prehospital system in Senegal and offer recommendations aimed at improving system capacity and population access to definitive care. METHODS: Structured interviews were conducted with key informants in various regions throughout the country using qualitative and quantitative techniques...
March 16, 2024: World Journal of Surgery
https://read.qxmd.com/read/38491747/alzheimer-s-disease-and-clinical-trials
#20
REVIEW
Deepraj Paul, Rohini Agrawal, Swati Singh
Alzheimer's disease (AD) is spreading its root disproportionately among the worldwide population. Many genes have been identified as the hallmarks of AD. Based upon the knowledge, many clinical trials have been designed and conducted. Attempts have been made to alleviate the pathology associated with AD by targeting the molecular products of these genes. Irrespective of the understanding on the genetic component of AD, many clinical trials have failed and imposed greater challenges on the path of drug discovery...
March 18, 2024: Journal of Basic and Clinical Physiology and Pharmacology
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