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https://www.readbyqxmd.com/read/29346729/electronic-interactions-in-iminophosphorane-superbase-complexes-with-carbon-dioxide
#1
Francesca Ingrosso, Manuel F Ruiz-Lopez
Iminophosphoranes or phosphazenes are an important class of compounds with increasing use in synthetic organic chemistry as neutral organic superbases exhibiting low nucleophilicity. Their electronic structure and therefore their properties strongly depend on substitution but there have been very few theoretical studies devoted to this topic, and more specifically to the formation of electron donor-acceptor complexes of iminophosphoranes with electrophiles. In this work, we have investigated the interaction with carbon dioxide at different ab initio levels...
January 18, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29346713/spark-generated-microbubble-cell-sorter-for-microfluidic-flow-cytometry
#2
Jingjing Zhao, Zheng You
High-speed and accurate cell sorting is of great significance for cell analysis regarding both bioresearch and clinical application. Different from the jet-in-air sorting of commercial flow cytometers, sorting in fully enclosed and disposal microfluidic chips can avoid aerosols and crosscontamination, thus contributing to the improvement of biosafety and test accuracy. However, current microfluidic sorters usually require complicated structures, or otherwise cannot attain high throughput. In this article, a sorting mechanism for microfluidics is proposed for the first time based on the jet flow induced by the spark-generated cavitation microbubble that can be easily realized by a pair of electrodes...
January 18, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29346437/tissue-specific-transcriptome-analyses-provide-new-insights-into-gpcr-signalling-in-adult-schistosoma-mansoni
#3
REVIEW
Steffen Hahnel, Nic Wheeler, Zhigang Lu, Arporn Wangwiwatsin, Paul McVeigh, Aaron Maule, Matthew Berriman, Timothy Day, Paula Ribeiro, Christoph G Grevelding
Schistosomes are blood-dwelling trematodes with global impact on human and animal health. Because medical treatment is currently based on a single drug, praziquantel, there is urgent need for the development of alternative control strategies. The Schistosoma mansoni genome project provides a platform to study and connect the genetic repertoire of schistosomes to specific biological functions essential for successful parasitism. G protein-coupled receptors (GPCRs) form the largest superfamily of transmembrane receptors throughout the Eumetazoan phyla, including platyhelminths...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29346395/evaluation-of-participatory-teaching-methods-in-undergraduate-medical-students-learning-along-the-first-academic-courses
#4
Beatriz Gal, Margarita Rubio, Eva Iglesias, Purificación González
The European Higher Education Area (EHEA) is an opportunity to redesign medical education. Academic training is now focused on acquiring not only knowledge, but also those competencies critical to face complex professional scenarios. Together with re-evaluating traditional teaching methods, EHEA has forced a technological shift in the way we teach. By critically assessing the impact of novel teaching methodologies, we can better define biomedical education demands. Here, we address this question on a sample of medical students instructed in basic subjects along the first two academic courses...
2018: PloS One
https://www.readbyqxmd.com/read/29346273/report-on-the-symposium-molecular-mechanisms-involved-in-neurodegeneration
#5
Giselle Pentón-Rol, Majel Cervantes-Llanos
The prevalence of neurodegenerative diseases is currently a major concern in public health because of the lack of neuroprotective and neuroregenerative drugs. The symposium on Molecular Mechanisms Involved in Neurodegeneration held in Varadero, Cuba, updated the participants on the basic mechanisms of neurodegeneration, on the different approaches for drug discovery, and on early research results on therapeutic approaches for the treatment of neurodegenerative diseases. Alzheimer's disease and in silico research were covered by many of the presentations in the symposium, under the umbrella of the "State of the Art of Non-clinical Models for Neurodegenerative Diseases" International Congress, held from 20 to 24 June 2017...
January 18, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29346223/learner-adaptive-educational-technology-for-simulation-in-healthcare-foundations-and-opportunities
#6
Matthew Lineberry, Parvati Dev, H Chad Lane, Thomas B Talbot
Despite evidence that learners vary greatly in their learning needs, practical constraints tend to favor "one-size-fits-all" educational approaches, in simulation-based education as elsewhere. Adaptive educational technologies - devices and/or software applications that capture and analyze relevant data about learners to select and present individually tailored learning stimuli - are a promising aid in learners' and educators' efforts to provide learning experiences that meet individual needs. In this article, we summarize and build upon the 2017 Society for Simulation in Healthcare Research Summit panel discussion on adaptive learning...
January 17, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29346168/a-new-robot-assisted-billroth-i-reconstruction-details-of-the-technique-and-early-results
#7
Graziano Ceccarelli, Luigi Marano, Massimo Codacci-Pisanelli, Enrico Andolfi, Alessia Biancafarina, Massimiliano Fabozzi, Stefano Caruso, Alberto Patriti
BACKGROUND: Laparoscopic surgery for gastric tumor is considered a demanding procedure because of lymph node dissection and reconstruction. Billroth-I (B-I) reconstruction after laparoscopic distal gastrectomy is commonly performed extracorporeally because of the complexity of an intracorporeal procedure. Robotic surgery overcomes some limitations of laparoscopy, allowing to reproduce the basic maneuvers of open surgery. We describe a new technique to perform robotic B-I anastomosis. METHODS: Between January 2012 and February 2015, 5 patients underwent distal gastrectomy with intracorporeal B-I-stapled anastomosis...
January 16, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29346108/modeling-of-electroporation-induced-by-pulsed-electric-fields-in-irregularly-shaped-cells
#8
Luciano Mescia, Michele A Chiapperino, Pietro Bia, Johan Gielis, Diego Caratelli
During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clarified, many research activities are focused on the development of suitable theoretical and numerical models. To this end, a nonlinear, nonlocal, dispersive, and space-time numerical algorithm has been developed and adopted to evaluate the transmembrane voltage and pore density along the perimeter of realistic irregularly shaped cells...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346064/using-two-disability-measures-to-compare-physical-inactivity-among-us-adults-with-disabilities
#9
Dana Olzenak McGuire, Kathleen B Watson, Dianna D Carroll, Elizabeth A Courtney-Long, Susan A Carlson
Prevalence of health behaviors among adults with disabilities may vary by disability measure. We used data from the 2011-2015 National Health Interview Survey to estimate prevalence of physical inactivity by disability status using 2 measures of disability: Basic Actions Difficulty questions (BADQ) and a standard 6-question measure (6Q). Disability prevalence (BADQ, 31.1%; 6Q, 17.5%) and inactivity prevalence among adults with disability (BADQ, 42.9%; 6Q, 52.5%) and without disability (BADQ, 24.3%; 6Q, 26.2%) varied by measure; however, both measures highlight inactivity disparities for adults with disability...
January 18, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29345890/how-medicare-could-provide-dental-vision-and-hearing-care-for-beneficiaries
#10
Amber Willink, Cathy Shoen, Karen Davis
Issue: The Medicare program specifically excludes coverage of dental, vision, and hearing services. As a result, many beneficiaries do not receive necessary care. Those that do are subject to high out-of-pocket costs. Goal: Examine gaps in access to dental, vision, and hearing services for Medicare beneficiaries and design a voluntary dental, vision, and hearing benefit plan with cost estimates. Methods: Uses the Medicare Current Beneficiary Survey, Cost and Use File, 2012, with population and costs projected to 2016 values...
January 1, 2018: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/29345636/promoting-the-accumulation-of-tumor-specific-t-cells-in-tumor-tissues-by-dendritic-cell-vaccines-and-chemokine-modulating-agents
#11
Nataša Obermajer, Julie Urban, Eva Wieckowski, Ravikumar Muthuswamy, Roshni Ravindranathan, David L Bartlett, Pawel Kalinski
This protocol describes how to induce large numbers of tumor-specific cytotoxic T cells (CTLs) in the spleens and lymph nodes of mice receiving dendritic cell (DC) vaccines and how to modulate tumor microenvironments (TMEs) to ensure effective homing of the vaccination-induced CTLs to tumor tissues. We also describe how to evaluate the numbers of tumor-specific CTLs within tumors. The protocol contains detailed information describing how to generate a specialized DC vaccine with augmented ability to induce tumor-specific CTLs...
February 2018: Nature Protocols
https://www.readbyqxmd.com/read/29345514/design-and-validation-of-an-instrumented-uneven-terrain-treadmill
#12
Alexandra S Voloshina, Daniel P Ferris
Studying human and animal locomotion on uneven terrain can be beneficial to basic science and applied studies for clinical and robotic applications. Traditional biomechanical analysis of human locomotion has often been limited to laboratory environments with flat, smooth runways and treadmills. We modified a regular exercise treadmill by attaching wooden blocks to the treadmill belt to yield an uneven locomotion surface. To ensure that these treadmill modifications facilitated biomechanical measurements, we compared ground reaction force data collected during running on the modified instrumented treadmill with a smooth surface to data collected using a conventional instrumented treadmill...
January 18, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29345486/facilitating-pipeline-progress-from-doctoral-degree-to-first-job
#13
Nadine J Kaslow, Debra A Bangasser, Catherine L Grus, Stephen R McCutcheon, Garth A Fowler
The sequence of professional development within psychology from doctoral education to first job represents a period of remarkable professional and personal growth for each trainee. However, this sequence also contains a variety of barriers that hinder progress through the pipeline. The myriad individual-, program-, and system-level barriers encountered by trainees in health service/other applied service psychology and in research basic/applied psychology are identified. To actively and systematically facilitate improved passage through major transition points, individual trainee and trainer, program- and system-level action steps are recommended...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29345417/catheter-based-edge-to-edge-mitral-valve-repair-for-pulmonary-pressure-reduction-and-to-postpone-heart-transplantation-in-a-teenaged-patient
#14
Moritz Messner, Florian Hintringer, Silvana Müller, Marc Michael Zaruba, Nikolaos Bonaros, Herwig Antretter, Daniel Basic, Gerhard Pölzl
We report a case of catheter-based edge-to-edge mitral valve repair in a teenage male patient with non-ischaemic cardiomyopathy to improve pulmonary hypertension secondary to severe functional mitral regurgitation (FMR) to defer anticipated heart transplantation. A 19-year-old patient with previous history of fulminant myocarditis followed by markedly left ventricular dysfunction presented with severe mitral regurgitation 3 years after initial recovery. Slightly over time, deterioration of FMR was associated with gradual increase in pulmonary artery pressures despite optimal medical therapy...
January 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29345327/basics-of-digital-microscopy
#15
Callen T Wallace, Morgan Jessup, Tytus Bernas, Karina A Peña, Michael J Calderon, Patricia A Loughran
Modern digital microscopy combines the equipment of classical light microscopy with a computerized imaging system. The technique comprises image formation by optics, image registration by a camera, and saving of image data in a computer file. This chapter describes limitations that are particular to each of these processes, including optical resolution, efficiency of image registration, characteristics of image file formats, and data management. Further suggestions are given which serve, in turn, to help construct a set of guidelines aimed at optimization of digital microscopic imaging...
January 18, 2018: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/29345323/vernalization-can-regulate-flowering-time-through-microrna-mechanism-in-brassica-rapa
#16
Feiyi Huang, Xiaoting Wu, Xilin Hou, Shuaixu Shao, Tongkun Liu
Vernalization is an important process that regulates the floral transition in plants. MiRNAs are endogenous non-coding sRNA molecules that function in plant growth and development. Despite that miRNAs related to flowering have previously been characterized, miRNAs roles in response to vernalization in Pak-choi (Brassica rapa ssp. chinensis) has never been studied. Here, two sRNA libraries from Brassica rapa leaves (vernalized and non-vernalized plants) were constructed and sequenced. 208 known and 535 novel miRNAs were obtained, of which 20 known and 66 new miRNAs were significantly differentially expressed and considered as vernalization-related miRNAs...
January 18, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29345100/relationship-between-orthodox-and-traditional-medical-practitioners-in-the-transmission-of-traditional-medical-knowledge-in-nigeria
#17
Janet O Adekannbi
BACKGROUND: The problem of incomplete transmission of traditional medical knowledge to the younger generation is of concern to information professionals especially in developing countries where most rural communities depend on traditional medicine for primary health care. OBJECTIVE: The purpose of this study was to investigate the collaboration between orthodox and traditional medical practitioners as well as the implication of the collaboration for transmission of traditional medical knowledge in Nigeria...
January 18, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29344997/integration-of-open-metal-sites-and-lewis-basic-sites-for-construction-of-a-cu-mof-with-rare-chiral-oh-type-of-cage-for-high-performance-of-methane-purification
#18
Zhan Shi, Lingkun Meng, Ziyuan Niu, Chen Liang, XingLong Dong, Kang Liu, Guanghua Li, Chunguang Li, Yu Han, Shouhua Feng
A Cu MOF [Cu4(PMTD)2(H2O)3]·20H2O, 1, (Where PMTD is (1,4-phenylenebis(5-methyl-4H-1,2,4-triazole-3,4-diyl)bis(5-carboxylato-3,1-phenylene)bis(hydroperoxymethanide) with rare chiral Oh type of cage and dual functionalities of open metal sites and Lewis basic sites based on a designed U-shaped ligand was synthesized by hydrothermal method. It exhibits high-capacity of CO2, C2 and C3 hydrocarbon storage capacity under atmospheric pressure as well as high H2 (1.96% wt) adsorption capacity at 77K. Methane purification capacity was tested and verified step by step...
January 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29344902/occupational-exposure-to-electromagnetic-fields-in-magnetic-resonance-environment-basic-aspects-and-review-of-exposure-assessment-approaches
#19
Valentina Hartwig, Stefania Romeo, Olga Zeni
The purpose of this review is to make a contribution to build a comprehensive knowledge of the main aspects related to the occupational exposure to electromagnetic fields (EMFs) in magnetic resonance imaging (MRI) environments. Information has been obtained from original research papers published in international peer-reviewed journals in the English language and from documents published by governmental bodies and authorities. An overview of the occupational exposure scenarios to static magnetic fields, motion-induced, time-varying magnetic fields, and gradient and radiofrequency fields is provided, together with a summary of the relevant regulation for limiting exposure...
January 18, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29344895/bioinformatics-approaches-to-predict-drug-responses-from-genomic-sequencing
#20
Neel S Madhukar, Olivier Elemento
Fulfilling the promises of precision medicine will depend on our ability to create patient-specific treatment regimens. Therefore, being able to translate genomic sequencing into predicting how a patient will respond to a given drug is critical. In this chapter, we review common bioinformatics approaches that aim to use sequencing data to predict sample-specific drug susceptibility. First, we explain the importance of customized drug regimens to the future of medical care. Second, we discuss the different public databases and community efforts that can be leveraged to develop new methods for identifying new predictive biomarkers...
2018: Methods in Molecular Biology
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