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https://www.readbyqxmd.com/read/28092807/application-of-the-dreadd-technique-in-biomedical-brain-research
#1
REVIEW
Grzegorz Dobrzanski, Małgorzata Kossut
The DREADD (Designer Receptors Exclusively Activated by Designer Drugs) technique is a new chemogenetic approach allowing for selective and remote control of neural activity with a high degree of spatial resolution. Since its discovery in 2007 the DREADD technique was successfully employed into basic research, and together with the optogenetic method provided so far the best tool to influence the activity of the brain circuits and cell populations. The first aim of this review was to concisely describe the technique with regard to such issues like the history of its development, biochemistry as well as modes of the designer receptors delivery and expression...
October 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28092789/facial-emotion-recognition-among-typically-developing-young-children-a-psychometric-validation-of-a-subset-of-nimstim-stimuli
#2
Lucy Barnard-Brak, Layla Abby, David M Richman, Steven Chesnut
We evaluated the psychometric properties of NimStim taking into account the effects of chronological age on the ability of typically developing young children (aged 2-6 years old) to recognize basic facial expressions (i.e., happy, sad, angry, and fearful). We also examined the psychometric sufficiency of NimStim under race-matched and -mismatched facial emotion stimuli. In the current study, race-matched stimuli referred to when children with African American backgrounds received African American faces to rate their emotions and vice versa for race-mismatched stimuli...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28092756/effects-of-assisted-outpatient-treatment-and-health-care-services-on-psychotic-symptoms
#3
Andres R Schneeberger, Christian G Huber, Undine E Lang, Kristina H Muenzenmaier, Dorothy Castille, Matthias Jaeger, Azizi Seixas, Julia Sowislo, Bruce G Link
RATIONALE: An ongoing debate concerns acceptability, benefits, and shortcomings of coercive treatment such as assisted outpatient treatment (AOT). The hypothesis that involuntary commitment to outpatient treatment may lead to a better clinical outcome for a subgroup of persons with severe mental illness (SMI) is controversial. Nonetheless, positive effects of AOT may be mediated by an increased availability of healthcare resources or increased service use. OBJECTIVE: The purpose of the present study is to evaluate the course of delusions, hallucinations, and negative symptoms among patients with SMI receiving AOT compared to patients receiving non-compulsory treatment (NCT)...
January 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28092751/the-effect-of-listing-the-lesser-prairie-chicken-as-a-threatened-species-on-rural-property-values
#4
Derek C Wietelman, Richard T Melstrom
This paper estimates the effect of Endangered Species Act protections for the lesser prairie chicken (Tympanuchus pallidicinctus) on rural property values in Oklahoma. The political and legal controversy surrounding the listing of imperiled species raises questions about the development restrictions and opportunity costs the Endangered Species Act imposes on private landowners. Examining parcel-level sales data before and after the listing of the endemic lesser prairie chicken, we employ difference-in-differences (DD) regression to measure the welfare costs of these restrictions...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28092715/-family-a-challenge-for-the-future-of-our-earth
#5
Gilberto A Gamboa-Bernal
The Universal Declaration of Human Rights recognizes the family as the basic cell of society, highlighting its importance, the need to protect it, to promote it as a natural and fundamental group unit of society. To reflect on the effects that the actual culture is in the family is important from the situation as it is now presented, then move to raise the changes seen necessary to ensure their own future and that of their habitat that is Earth. To accomplish this first task some study results World Family Map 2015 is glossed...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092631/optoelectrofluidic-printing-system-for-fabricating-hydrogel-sheets-with-on-demand-patterned-cells-and-microparticles
#6
Hyun Ji Gi, Dongsik Han, Je-Kyun Park
This paper presents a novel optoelectrofluidic printing system that facilitates not only the optoelectrofluidic patterning of microparticles and mammalian cells but also the harvesting of the patterned microparticles encapsulated within poly(ethylene glycol) dicarylate (PEGDA) hydrogel sheets. Although optoelectrofluidic technology has numerous advantages for programmable and on-demand patterning and the feasibility of manipulating single microparticles, practical applications using existing laboratory infrastructure in biological and clinical research fields have been strictly restricted due to the impossibility of recovering the final patterned product...
January 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28092613/effects-of-udder-infections-with-staphylococcus-xylosus-and-staphylococcus-warneri-on-the-composition-and-physicochemical-changes-in-cows-milk
#7
M Vasil, E Pecka-Kiełb, J Elečko, A Zachwieja, W Zawadzki, F Zigo, J Illek, Z Farkašová
The aim of this study was an evaluation of the effects of two species of coagulase negative staphylococci (CNS), Staphylococcus xylosus and Staphylococcus warneri, on the changes in technological parameters of cows' milk. The study was conducted in a herd of Slovak Pied cattle breed (with share of HF blood). Based on the performance results from three subsequent months, cows in the 2nd and 3rd lactation with SCC up to 200 thousand/ml (8 heads, 32 quarters), and above 800 thousand/ml (8 heads, 32 quarters), after the 4th month of lactation, were selected...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28092519/newton-type-greedy-selection-methods-for-ell_0-constrained-minimization
#8
Xiao-Tong Yuan, Qingshan Liu
We introduce a family of Newton-type greedy selection methods for ℓ0-constrained minimization problems. The basic idea is to construct a quadratic function to approximate the original objective function around the current iterate and solve the constructed quadratic program over the cardinality constraint. The next iterate is then estimated via a line search operation between the current iterate and the solution of the sparse quadratic program. This iterative procedure can be interpreted as an extension of the constrained Newton methods from convex minimization to non-convex ℓ0-constrained minimization...
January 11, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28092486/use-of-polyclonal-monoclonal-antibody-therapies-in-transplantation
#9
Melissa Y Yeung, Steven Gabardi, Mohamed H Sayegh
For over thirty years, antibody (mAb)-based therapies have been a standard component of transplant immunosuppression, and yet much remains to be learned in order for us to truly harness their therapeutic capabilities. Current mAbs used in transplant directly target and destroy graft-destructive immune cells, interrupt cytokine and costimulation-dependent T and B cell activation, and prevent down-stream complement activation. Areas covered: This review summarizes our current approaches to using antibody-based therapies to prevent and treat allograft rejection...
January 16, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28092471/genomics-pipelines-and-data-integration-challenges-and-opportunities-in-the-research-setting
#10
Jeremy Davis-Turak, Sean M Courtney, E Starr Hazard, W Bailey Glen, Willian da Silveira, Timothy Wesselman, Larry P Harbin, Bethany J Wolf, Dongjun Chung, Gary Hardiman
The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine...
January 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28092438/biofunctionalization-of-nerve-interface-via-biocompatible-polymer-roughened-pt-black-on-cuff-electrode-for-chronic-recording
#11
Yi Jae Lee, Han-Jun Kim, Ji Yoon Kang, Sun Hee Do, Soo Hyun Lee
Peripheral nerve cuff electrodes with roughened Pt black (BPt) are coated with polyethylene glycol (PEG) and Nafion (NF). Although the influence of coated PEG and Nafion on roughened BPt on the electrical properties is weak, the cuff electrode with BPt/PEG and BPt/Nafion exhibits some very important properties. For example, it markedly decreases interfacial impedance, increases charge storage capacity (CSC) due to retaining the BPt surface structure, good stability without exfoliation in repetitive cyclic voltammetry scanning because it is protected by PEG or Nafion coating...
January 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28092321/dexmedetomidine-disrupts-the-local-and-global-efficiencies-of-large-scale-brain-networks
#12
Javeria A Hashmi, Marco L Loggia, Sheraz Khan, Lei Gao, Jieun Kim, Vitaly Napadow, Emery N Brown, Oluwaseun Akeju
BACKGROUND: A clear understanding of the neural basis of consciousness is fundamental to research in clinical and basic neuroscience disciplines and anesthesia. Recently, decreased efficiency of information integration was suggested as a core network feature of propofol-induced unconsciousness. However, it is unclear whether this finding can be generalized to dexmedetomidine, which has a different molecular target. METHODS: Dexmedetomidine was administered as a 1-μg/kg bolus over 10 min, followed by a 0...
January 16, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28092282/neonatal-palliative-care
#13
Elvira Parravicini
PURPOSE OF REVIEW: A significant number of newborns are affected by life-limiting or life-threatening conditions. When prolongation of survival is no longer a goal, or prognosis is uncertain, a plan of care focused on the infant's comfort is essential. The aim of this article is to review the most recent and relevant literature regarding neonatal palliative care (NPC). RECENT FINDINGS: A variety of perinatal and NPC programs are described, but most programs focus exclusively on end-of-life care...
January 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28092244/-depression-and-burden-on-primary-caregivers-of-elderly-persons-with-physical-dependence-of-the-umf-171
#14
Cristina Navarro-Sandoval, Lizbeth Carlota Uriostegui-Espíritu, Edna Gabriela Delgado-Quiñones, Minerva Natalia Sahagún-Cuevas
BACKGROUND: According to the National Health and Nutrition Survey of 2012, more than a quarter of older adults (26.9%) have some degree of disability, requiring a primary caregiver to perform basic activities of daily living. The aim is to determine the prevalence of depression and burden on primary caregivers of elderly persons with physical dependence. METHODS: A descriptive cross-sectional study with non-probability sampling that included the primary caregivers of elderly patients with physical dependence...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28092230/octamethylcyclotetrasiloxane-d4
#15
(no author information available yet)
Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhalation routes of exposure and is not considered to be a dermal or eye irritant or to be a dermal sensitizer. There is no appreciable dermal absorption of D4 based on results from in vivo and in vitro studies...
January 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28092154/correlating-the-network-topology-of-oxide-glasses-with-their-chemical-durability
#16
Nerea Mascaraque, Mathieu Bauchy, Morten M Smedskjaer
Glasses gradually dissolve and corrode when they are exposed to aqueous solutions and for many applications it is necessary to understand and predict the kinetics of the glass dissolution. Despite the recent progress in understanding the impact of chemical composition on the dissolution rate, a detailed understanding of the structural and topological origin of chemical durability in solutions of different pH is still largely lacking. Such knowledge would enable the tailoring of glass dissolution kinetics as a function of chemical composition...
January 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28092053/sh2-domain-based-fret-biosensor-for-measuring-bcr-abl-activity-in-living-cml-cells
#17
Mari Fujioka, Yumi Asano, Shigeyuki Nakada, Yusuke Ohba
Fluorescent proteins (FPs) displaying distinct spectra have shed their light on a wide range of biological functions. Moreover, sophisticated biosensors engineered to contain single or multiple FPs, including Förster resonance energy transfer (FRET)-based biosensors, spatiotemporally reveal the molecular mechanisms underlying a variety of pathophysiological processes. However, their usefulness for applied life sciences has yet to be fully explored. Recently, our research group has begun to expand the potential of FPs from basic biological research to the clinic...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28092006/the-efficiency-of-eichhornia-crassipes-in-the-removal-of-organic-and-inorganic-pollutants-from-wastewater-a-review
#18
Saurabh Mishra, Abhijit Maiti
Water is a basic necessity of life, but due to overextraction and heavy input of nutrients from domestic and industrial sources, the contamination level of water bodies increase. In the last few decades, a potential interest has been aroused to treat wastewater by biological methodologies before discharge into the natural water bodies. Phytoremediation using water hyacinth is found to be an effective biological wastewater treatment method. Water hyacinth (Eichhornia crassipes), a notorious weed, being the most promising plant for removal of contaminants from wastewater is studied extensively in this regard...
January 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091999/porous-nano-cerium-oxide-wood-chip-biochar-composites-for-aqueous-levofloxacin-removal-and-sorption-mechanism-insights
#19
Shengze Yi, Yuanyuan Sun, Xin Hu, Hongxia Xu, Bin Gao, Jichun Wu
The adsorption removal of levofloxacin (LEV), a widely used fluoroquinolone antibiotic, by using the biochars derived from the pyrolysis of pine wood chip pretreated with cerium trichloride was investigated through batch sorption experiments and multiple characterization techniques. The differences in the basic physicochemical properties between Ce-impregnated biochars and the pristine biochars were confirmed by the analysis of elemental compositions, specific surface areas, energy dispersive spectrometry, X-ray diffraction, and thermo-gravimetry...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091948/demonstration-of-logic-operations-in-high-performance-rram-crossbar-array-fabricated-by-atomic-layer-deposition-technique
#20
Runze Han, Peng Huang, Yudi Zhao, Zhe Chen, Lifeng Liu, Xiaoyan Liu, Jinfeng Kang
In this paper, resistive random access memory (RRAM)-based crossbar arrays with the cell structure of Pt/[AlO y /HfO x ] m /TiN were fabricated by using atomic layer deposition (ALD) technique. The RRAM devices in the arrays show excellent performances such as good uniformity and high reliability. Based on the fabricated RRAM array, a complete set of basic logic operations including NOR and XNOR were successfully demonstrated.
December 2017: Nanoscale Research Letters
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