keyword
https://read.qxmd.com/read/38515009/a-retrospective-study-to-compare-the-glasgow-coma-score-pediatric-trauma-score-and-injury-severity-score-and-outcomes-in-118-pediatric-trauma-patients-at-a-single-emergency-center-in-turkey
#21
JOURNAL ARTICLE
Habibe Selmin Özensoy, Selahattin Gürü
BACKGROUND The main causes of accidental trauma in children include road traffic accidents (RTAs) and falling from height (FFH). Rapid and accurate assessment of severity of injury is required to guide effective management. This retrospective study aimed to compare the Glasgow Coma Score (GCS), Pediatric Trauma Score (PTS), and Injury Severity Score (ISS) and outcomes for 118 pediatric trauma patients at a single Emergency Department (ED) in Turkey. MATERIAL AND METHODS Patients admitted to Ankara City Hospital due to high-energy trauma between November 1, 2019 and April 30, 2020 were analyzed retrospectively...
March 22, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38512528/clinical-features-pathogenesis-pathology-neuroimaging-clinical-course-and-outcome-of-measles-inclusion-body-encephalitis-a-systematic-review-of-published-case-reports-and-case-series
#22
REVIEW
Ravindra Kumar Garg, Vinay Suresh, Swastika Suvirya, Imran Rizvi, Neeraj Kumar, Shweta Pandey
Measles inclusion-body encephalitis (MIBE) is rare, with insights largely from case studies. We systematically analyzed subacute Sclerosing Panencephalitis (SSPE) cases in immunocompromised patients, identifying distinctive clinical and neuroimaging features. These findings could facilitate MIBE diagnosis without the need for brain biopsies. Our systematic review on MIBE and HIV-related SSPE adhered to PRISMA guidelines and was registered with PROSPERO. We searched multiple databases and followed a detailed inclusion process with independent reviews and quality assessment...
March 21, 2024: Neurological Sciences
https://read.qxmd.com/read/38512045/a-randomised-double-blind-placebo-controlled-trial-of-a-two-week-course-of-dexamethasone-for-adult-patients-with-a-symptomatic-chronic-subdural-haematoma-dex-csdh-trial
#23
RANDOMIZED CONTROLLED TRIAL
Peter J Hutchinson, Ellie Edlmann, John G Hanrahan, Diederik Bulters, Ardalan Zolnourian, Patrick Holton, Nigel Suttner, Kevin Agyemang, Simon Thomson, Ian A Anderson, Yahia Al-Tamimi, Duncan Henderson, Peter Whitfield, Monica Gherle, Paul M Brennan, Annabel Allison, Eric P Thelin, Silvia Tarantino, Beatrice Pantaleo, Karen Caldwell, Carol Davis-Wilkie, Harry Mee, Elizabeth A Warburton, Garry Barton, Aswin Chari, Hani J Marcus, Sarah Pyne, Andrew T King, Antonio Belli, Phyo K Myint, Ian Wilkinson, Thomas Santarius, Carole Turner, Simon Bond, Angelos G Kolias
BACKGROUND: Chronic subdural haematoma is a collection of 'old blood' and its breakdown products in the subdural space and predominantly affects older people. Surgical evacuation remains the mainstay in the management of symptomatic cases. OBJECTIVE: The Dex-CSDH (DEXamethasone in Chronic SubDural Haematoma) randomised trial investigated the clinical effectiveness and cost-effectiveness of dexamethasone in patients with a symptomatic chronic subdural haematoma. DESIGN: This was a parallel, superiority, multicentre, pragmatic, randomised controlled trial...
March 2024: Health Technology Assessment: HTA
https://read.qxmd.com/read/38511552/seizures-focal-neurological-signs-and-pneumococcal-aetiology-associate-with-impaired-consciousness-in-childhood-bacterial-meningitis
#24
JOURNAL ARTICLE
Ester Valtiala, Irmeli Roine, Manuel Leite Cruzeiro, Heikki Peltola, Tuula Pelkonen
AIM: A low Glasgow Coma Scale Score (GCS) on admission is a known predictor of poor outcome from childhood bacterial meningitis. In turn, the factors associated with the admission GCS are less known. Our aim was to identify them, both for clinical alerts of reserved prognosis and to find potential targets for intervention. METHODS: This study is a secondary analysis of data collected prospectively in Angola and in Latin America between 1996 and 2007. Children with bacterial meningitis were examined on hospital admission and their GCS was assessed using the age-adjusted scale...
March 21, 2024: Acta Paediatrica
https://read.qxmd.com/read/38510921/vipera-viral-intra-patient-evolution-reporting-and-analysis
#25
JOURNAL ARTICLE
Miguel Álvarez-Herrera, Jordi Sevilla, Paula Ruiz-Rodriguez, Andrea Vergara, Jordi Vila, Pablo Cano-Jiménez, Fernando González-Candelas, Iñaki Comas, Mireia Coscollá
Viral mutations within patients nurture the adaptive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during chronic infections, which are a potential source of variants of concern. However, there is no integrated framework for the evolutionary analysis of intra-patient SARS-CoV-2 serial samples. Herein, we describe Viral Intra-Patient Evolution Reporting and Analysis (VIPERA), a new software that integrates the evaluation of the intra-patient ancestry of SARS-CoV-2 sequences with the analysis of evolutionary trajectories of serial sequences from the same viral infection...
2024: Virus Evolution
https://read.qxmd.com/read/38510779/clinical-profile-and-predictors-of-intensive-care-admission-in-neonicotinoid-poisoning-in-a-tertiary-care-hospital-in-south-india
#26
JOURNAL ARTICLE
Lalhming Sanga, Amita Jacob, Jonathan Arul Jeevan Jayakaran, Ramya Iyadurai
BACKGROUND AND OBJECTIVES: Neonicotinoids are a newer class of pesticides that are believed to cause predominantly mild toxicity in humans. This study aimed to describe the clinical features of neonicotinoid poisoning and identify predictors of severe toxicity. MATERIALS AND METHODS: This retrospective study included all patients with neonicotinoid poisoning admitted to a Tertiary Care Center in India over an 18-year period. Clinical and laboratory features were compared against outcomes to identify predictors of the need for intensive care admission...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510220/brain-calcifications-secondary-to-idiopathic-hyperthyroidism-and-hypoparathyroidism
#27
Bushra Zafar Sayeed, Faiza Zafar Sayeed, Muhammad Nashit, Shaheen Bhatty
Background: Thyroid and parathyroid hormones are essential components of the metabolic system and its regulation. Concurrent hyperthyroidism with hypoparathyroidism is an extremely rare finding and is not considered a common etiology of brain calcifications seen on imaging. Brain calcifications can cause a range of neurologic symptoms, including movement disorders, cognitive impairment, and seizures. Prompt recognition and treatment of hypoparathyroidism are essential to prevent or minimize the development of brain calcifications and associated neurologic symptoms...
2024: Ochsner Journal
https://read.qxmd.com/read/38509924/a-nomogram-for-predicting-the-necessity-of-tracheostomy-after-severe-acute-brain-injury-in-patients-within-the-neurosurgery-intensive-care-unit-a-retrospective-cohort-study
#28
JOURNAL ARTICLE
Liqin Gao, Yafen Chang, Siyuan Lu, Xiyang Liu, Xiang Yao, Wei Zhang, Eryi Sun
OBJECTIVE: This retrospective study was aimed to develop a predictive model for assessing the necessity of tracheostomy (TT) in patients admitted to the neurosurgery intensive care unit (NSICU). METHOD: We analyzed data from 1626 NSICU patients with severe acute brain injury (SABI) who were admitted to the Department of NSICU at the Affiliated People's Hospital of Jiangsu University between January 2021 and December 2022. Data of the patients were retrospectively obtained from the clinical research data platform...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508739/inter-rater-reliability-in-the-assessment-of-consciousness-in-patients-receiving-palliative-care-in-intensive-care-a-prospective-cross-sectional-observational-study
#29
JOURNAL ARTICLE
Dilek Yildirim, Arzu Kavala, Seda Değirmenci Öz, Esra Sezer, Emre Kuğu, Zeynep Coşkun
BACKGROUND: The Glasgow Coma Scale (GCS) is one of the methods that has validity for evaluating the consciousness levels of patients in the literature and is accepted by health authorities. AIM: The purpose of this study was to evaluate the inter-rater reliability of GCS in intensive care patients receiving palliative care. STUDY DESIGN: A prospective cross sectional observational study. The study was conducted in a general intensive care unit with 20 beds with patients receiving palliative care...
March 20, 2024: Nursing in Critical Care
https://read.qxmd.com/read/38508596/management-of-an-acute-intracranial-emergency-in-pregnancy
#30
JOURNAL ARTICLE
Petronella Brokkelkamp, Jelle H Baalman, Maarten J Driesse, Kuan H Kho
We report a case of a mid-20s primigravida at 37 weeks' gestation who presented with severe headache and acute neurological deterioration. The CT brain scan showed hydrocephalus caused by a colloid cyst in the third ventricle. The patient underwent emergency placement of an external ventricular drain for decompression of acute hydrocephalus. Four hours later, labour commenced spontaneously, and in view of her neurological status, a decision was taken to perform a caesarean section under general anaesthetics...
March 19, 2024: BMJ Case Reports
https://read.qxmd.com/read/38506972/added-value-of-frequency-of-imaging-markers-for-prediction-of-outcome-after-intracerebral-hemorrhage-a-secondary-analysis-of-existing-data
#31
JOURNAL ARTICLE
Lianghong Kuang, Shinuan Fei, Hang Zhou, Le Huang, Cailian Guo, Jun Cheng, Wenmin Guo, Yu Ye, Rujia Wang, Hui Xiong, Ji Zhang, Dongfang Tang, Liwei Zou, Xiaoming Qiu, Yongqiang Yu, Lei Song
BACKGROUND: Frequency of imaging markers (FIM) has been identified as an independent predictor of hematoma expansion in patients with intracerebral hemorrhage (ICH), but its impact on clinical outcome of ICH is yet to be determined. The aim of the present study was to investigate this association. METHODS: This study was a secondary analysis of our prior research. The data for this study were derived from six retrospective cohorts of ICH from January 2018 to August 2022...
March 20, 2024: Neurocritical Care
https://read.qxmd.com/read/38505971/rapid-triage-and-transfer-system-for-patients-with-proven-covid-19-at-emergency-department
#32
JOURNAL ARTICLE
Martin Jakl, Jana Berkova, Tomas Veleta, Vladimir Palicka, Petra Polcarova, Jan Smetana, Petr Grenar, Martina Cermakova, Jan Vanek, Jan M Horacek, Jaromir Koci
BACKGROUND: COVID-19 is a viral disease notorious for frequent worldwide outbreaks. It is difficult to control, thereby resulting in overload of the healthcare system. A possible solution to prevent overcrowding is rapid triage of patients, which makes it possible to focus care on the high-risk patients and minimize the impact of crowding on patient prognosis. METHODS: The triage algorithm assessed self-sufficiency, oximetry, systolic blood pressure, and the Glasgow coma scale...
March 2024: Journal of Applied Biomedicine
https://read.qxmd.com/read/38504548/complementary-and-alternative-medicine-on-cognitive-defects-and-neuroinflammation-after-sepsis
#33
JOURNAL ARTICLE
L I Zhenxuan, Wang Xuerui, Luis Ulloa, Ayman Youssef, Bai Yunjing, X U Xiaolong, Liu Qingquan
Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504296/abnormal-levels-of-expression-of-micrornas-in-peripheral-blood-of-patients-with-traumatic-brain-injury-are-induced-by-microglial-activation-and-correlated-with-severity-of-injury
#34
JOURNAL ARTICLE
Shuo Feng, Zhangying Wu, Xianping Zheng, Zhiwei Shao, Qiang Lin, Shoutian Sun
BACKGROUND: Microglia play a crucial role in regulating the progression of traumatic brain injury (TBI). In specific, microglia can self-activate and secrete various substances that exacerbate or alleviate the neuroimmune response to TBI. In addition, microRNAs (miRNAs) are involved in the functional regulation of microglia. However, molecular markers that reflect the dynamics of TBI have not yet been found in peripheral tissues. METHODS: Paired samples of peripheral blood were collected from patients with TBI before and after treatment...
March 20, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38504178/characteristics-of-ocular-injuries-associated-with-mortality-in-patients-admitted-with-major-trauma
#35
JOURNAL ARTICLE
Sruthi Kodali, Catherine H He, Sheel Patel, Alice Tao, Moshe Szlechter, Afshin Parsikia, Joyce N Mbekeani
BACKGROUND: Few ocular trauma studies have addressed mortality outcomes. We sought to determine characteristics of mortality-related ocular trauma admissions and compared them with non-fatal injuries. METHODS: A retrospective study was conducted using de-identified data of patients admitted with major trauma from the National Trauma Data Bank (2008-2014). Patients with ocular injury were identified using ICD- 9CM codes. Demographics, intention and mechanism, types of ocular and head injuries, and injury severity were documented...
March 19, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38502856/testing-the-validity-of-three-acute-care-assessment-tools-for-assessing-residents-performance-during-in-situ-simulation-the-acat-simsit-study
#36
JOURNAL ARTICLE
Anne-Laure Philippon, Antoine Lefevre-Scelles, Xavier Eyer, Carine Zumstein, Aiham Ghazali, Simon Audibert, Pierrick Le Borgne, Emmanuel Triby, Jennifer Truchot
BACKGROUND: The assessment of technical and nontechnical skills in emergency medicine requires reliable and usable tools. Three Acute Care Assessment Tools (ACATs) have been developed to assess medical learners in their management of cardiac arrest (ACAT-CA), coma (ACAT-coma) and acute respiratory failure (ACAT-ARF). OBJECTIVE: This study aims to analyze the reliability and usability of the three ACATs when used for in situ (bedside) simulation. METHODS: This prospective multicenter validation study tested ACATs using interprofessional in situ simulations in seven emergency departments and invited training residents to participate in them...
March 19, 2024: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://read.qxmd.com/read/38502553/neck-muscle-spasticity-in-patients-with-disorder-of-consciousness-a-pilot-study
#37
JOURNAL ARTICLE
Valeria Pingue, Marta Mirando, Benedetta Cazzulani, Gianluca Bellaviti, Filippo Saporiti, Cristina Zanga, Antonio Nardone
BACKGROUND: Disorder of consciousness (DOC) is a state of prolonged altered consciousness due to severe acquired brain injury (ABI). DOC can be differentiated into coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS) depending on the behavioral features observed and their relationship to the level of consciousness. Spasticity is one of the most frequently reported medical comorbidities in DOC patients. Since there is a critical lack of spasticity-focused studies and, in turn, of target treatment, we designed this pilot prospective study to evaluate cervical spine muscle spasticity and its effect on rehabilitation outcome in a large cohort of patients followed from the post-acute phase to 6 months after severe ABI...
March 19, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38502464/critical-care-management-of-acute-intoxications-dynamics-and-changes-over-time-a-cohort-study
#38
JOURNAL ARTICLE
Alexander Christian Reisinger, Nikolaus Schneider, Nikolaus Schreiber, Martina Janisch, Ines Rauch, Peter Kaufmann, Gerrit Wünsch, Philipp Eller, Gerald Hackl
Acute intoxications and poisonings are a relevant cause for ICU admission of critically ill patients. This study aimed to determine the characteristics of intoxicated patients in a tertiary center medical ICU in Austria over time and to investigate parameters associated with ICU mortality. This study was a retrospective data analysis including adult ICU patients from the years 2007 to 2021. In addition to ICU documentation, pre-hospital, and emergency department documents as well as autopsy reports were utilized...
March 19, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38500500/development-and-validation-a-nomogram-prediction-model-for-early-diagnosis-of-bloodstream-infections-in-the-intensive-care-unit
#39
JOURNAL ARTICLE
Zhili Qi, Lei Dong, Jin Lin, Meili Duan
PURPOSE: This study aims to develop and validate a nomogram for predicting the risk of bloodstream infections (BSI) in critically ill patients based on their admission status to the Intensive Care Unit (ICU). PATIENTS AND METHODS: Patients' data were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database (training set), the Beijing Friendship Hospital (BFH) database (validation set) and the eICU Collaborative Research Database (eICU-CRD) (validation set)...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38500233/a-descriptive-study-of-stroke-types-risk-factors-clinical-features-and-outcomes-in-a-tertiary-hospital-in-myanmar
#40
JOURNAL ARTICLE
Thant Zin Tun, Su Myat Han, Kazuhiko Moji, Mitsuaki Matsui
BACKGROUND: Stroke is a leading cause of death in the world, and the burden of stroke is higher in low- and middle-income countries. Understanding the risk factors, complications, and outcomes of stroke are useful for healthcare planning and resource allocation. Little information on stroke is available for many low- and middle-income Asian countries; including Myanmar, which is the focus of this study. METHODS: A review was conducted of medical records for stroke admissions during 2017 in a tertiary hospital in Myanmar...
March 18, 2024: Tropical Medicine and Health
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